TURTI	GO:0004984	olfactory receptor activity	Gains
TURTI	GO:0005549	odorant binding	Gains
TURTI	GO:0004888	transmembrane signaling receptor activity	Gains
TURTI	GO:0099600	transmembrane receptor activity	Gains
TURTI	GO:0004930	G-protein coupled receptor activity	Gains
TURTI	GO:0038023	signaling receptor activity	Gains
TURTI	GO:0004872	receptor activity	Gains
TURTI	GO:0060089	molecular transducer activity	Gains
TURTI	GO:0008527	taste receptor activity	Gains
TURTI	GO:0031409	pigment binding	Gains
TURTI	GO:0004871	signal transducer activity	Gains
TURTI	GO:0005215	transporter activity	Gains
TURTI	GO:0015075	ion transmembrane transporter activity	Gains
TURTI	GO:0022892	substrate-specific transporter activity	Gains
TURTI	GO:0022891	substrate-specific transmembrane transporter activity	Gains
TURTI	GO:0022890	inorganic cation transmembrane transporter activity	Gains
TURTI	GO:0022857	transmembrane transporter activity	Gains
TURTI	GO:0046873	metal ion transmembrane transporter activity	Gains
TURTI	GO:0015267	channel activity	Gains
TURTI	GO:0022803	passive transmembrane transporter activity	Gains
TURTI	GO:0008324	cation transmembrane transporter activity	Gains
TURTI	GO:0005261	cation channel activity	Gains
TURTI	GO:0005216	ion channel activity	Gains
TURTI	GO:0005272	sodium channel activity	Gains
TURTI	GO:0022838	substrate-specific channel activity	Gains
TURTI	GO:0005506	iron ion binding	Gains
TURTI	GO:0015408	ferric-transporting ATPase activity	Gains
TURTI	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Gains
TURTI	GO:0015091	ferric iron transmembrane transporter activity	Gains
TURTI	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
TURTI	GO:0070330	aromatase activity	Gains
TURTI	GO:0005381	iron ion transmembrane transporter activity	Gains
TURTI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
TURTI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
TURTI	GO:0003995	acyl-CoA dehydrogenase activity	Gains
TURTI	GO:0016491	oxidoreductase activity	Gains
TURTI	GO:0005184	neuropeptide hormone activity	Gains
TURTI	GO:0047429	nucleoside-triphosphate diphosphatase activity	Gains
TURTI	GO:0042826	histone deacetylase binding	Gains
TURTI	GO:0015020	glucuronosyltransferase activity	Gains
TURTI	GO:0005179	hormone activity	Gains
TURTI	GO:0008395	steroid hydroxylase activity	Gains
TURTI	GO:0016247	channel regulator activity	Gains
TURTI	GO:0015081	sodium ion transmembrane transporter activity	Gains
TURTI	GO:0019788	NEDD8 transferase activity	Gains
TURTI	GO:0033041	sweet taste receptor activity	Gains
TURTI	GO:0003997	acyl-CoA oxidase activity	Gains
TURTI	GO:0003913	DNA photolyase activity	Gains
TURTI	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Gains
TURTI	GO:0015288	porin activity	Gains
TURTI	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Gains
TURTI	GO:0017080	sodium channel regulator activity	Gains
TURTI	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Gains
TURTI	GO:0004170	dUTP diphosphatase activity	Gains
TURTI	GO:0005262	calcium channel activity	Gains
TURTI	GO:0004197	cysteine-type endopeptidase activity	Gains
TURTI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
TURTI	GO:0022836	gated channel activity	Gains
TURTI	GO:0046915	transition metal ion transmembrane transporter activity	Gains
TURTI	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Gains
TURTI	GO:0031420	alkali metal ion binding	Gains
TURTI	GO:0004743	pyruvate kinase activity	Gains
TURTI	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
TURTI	GO:0036002	pre-mRNA binding	Gains
TURTI	GO:0030955	potassium ion binding	Gains
TURTI	GO:0048018	receptor ligand activity	Gains
TURTI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
TURTI	GO:0020037	heme binding	Gains
TURTI	GO:0003964	RNA-directed DNA polymerase activity	Losses
TURTI	GO:0034061	DNA polymerase activity	Losses
TURTI	GO:0140097	catalytic activity, acting on DNA	Losses
TURTI	GO:0008270	zinc ion binding	Losses
TURTI	GO:0070001	aspartic-type peptidase activity	Losses
TURTI	GO:0004190	aspartic-type endopeptidase activity	Losses
TURTI	GO:0046914	transition metal ion binding	Losses
TURTI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
TURTI	GO:0046872	metal ion binding	Losses
TURTI	GO:0043169	cation binding	Losses
TURTI	GO:0016779	nucleotidyltransferase activity	Losses
TURTI	GO:0008233	peptidase activity	Losses
TURTI	GO:0140096	catalytic activity, acting on a protein	Losses
TURTI	GO:0043167	ion binding	Losses
TURTI	GO:0008484	sulfuric ester hydrolase activity	Losses
TURTI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
TURTI	GO:0004180	carboxypeptidase activity	Losses
TURTI	GO:0004047	aminomethyltransferase activity	Losses
TURTI	GO:0004175	endopeptidase activity	Losses
TURTI	GO:0003824	catalytic activity	Losses
TURTI	GO:0005509	calcium ion binding	Losses
TURTI	GO:0016740	transferase activity	Losses
TURTI	GO:0004803	transposase activity	Losses
TURTI	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Losses
TURTI	GO:0016917	GABA receptor activity	Losses
TURTI	GO:0031419	cobalamin binding	Losses
TURTI	GO:0047462	phenylalanine racemase (ATP-hydrolyzing) activity	Losses
TURTI	GO:0004890	GABA-A receptor activity	Losses
TURTI	GO:0004594	pantothenate kinase activity	Losses
TURTI	GO:0015154	disaccharide transmembrane transporter activity	Losses
TURTI	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
TURTI	GO:0001614	purinergic nucleotide receptor activity	Losses
TURTI	GO:0030507	spectrin binding	Losses
TURTI	GO:0047661	amino-acid racemase activity	Losses
TURTI	GO:0008445	D-aspartate oxidase activity	Losses
TURTI	GO:0003884	D-amino-acid oxidase activity	Losses
TURTI	GO:0015922	aspartate oxidase activity	Losses
TURTI	GO:0016502	nucleotide receptor activity	Losses
TURTI	GO:0036361	racemase activity, acting on amino acids and derivatives	Losses
TURTI	GO:0009975	cyclase activity	Losses
TURTI	GO:0019901	protein kinase binding	Losses
TURTI	GO:0004383	guanylate cyclase activity	Losses
TURTI	GO:0004672	protein kinase activity	Losses
TURTI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
TURTI	GO:0004842	ubiquitin-protein transferase activity	Losses
TURTI	GO:0015276	ligand-gated ion channel activity	Losses
TURTI	GO:0022834	ligand-gated channel activity	Losses
TURTI	GO:0008238	exopeptidase activity	Losses
TURTI	GO:0019787	ubiquitin-like protein transferase activity	Losses
TURTI	GO:0005230	extracellular ligand-gated ion channel activity	Losses
TURTI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
TURTI	GO:0140097	catalytic activity, acting on DNA	Extinctions
TURTI	GO:0034061	DNA polymerase activity	Extinctions
TURTI	GO:0008270	zinc ion binding	Extinctions
TURTI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
TURTI	GO:0046914	transition metal ion binding	Extinctions
TURTI	GO:0004047	aminomethyltransferase activity	Extinctions
TURTI	GO:0046872	metal ion binding	Extinctions
TURTI	GO:0043169	cation binding	Extinctions
TURTI	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
TURTI	GO:0043167	ion binding	Extinctions
TURTI	GO:0070001	aspartic-type peptidase activity	Extinctions
TURTI	GO:0004190	aspartic-type endopeptidase activity	Extinctions
TURTI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
TURTI	GO:0016779	nucleotidyltransferase activity	Extinctions
TURTI	GO:0008484	sulfuric ester hydrolase activity	Extinctions
TURTI	GO:0031419	cobalamin binding	Extinctions
TURTI	GO:0047462	phenylalanine racemase (ATP-hydrolyzing) activity	Extinctions
TURTI	GO:0001614	purinergic nucleotide receptor activity	Extinctions
TURTI	GO:0030507	spectrin binding	Extinctions
TURTI	GO:0047661	amino-acid racemase activity	Extinctions
TURTI	GO:0008445	D-aspartate oxidase activity	Extinctions
TURTI	GO:0003884	D-amino-acid oxidase activity	Extinctions
TURTI	GO:0015922	aspartate oxidase activity	Extinctions
TURTI	GO:0016502	nucleotide receptor activity	Extinctions
TURTI	GO:0036361	racemase activity, acting on amino acids and derivatives	Extinctions
TURTI	GO:0140096	catalytic activity, acting on a protein	Extinctions
TURTI	GO:0008233	peptidase activity	Extinctions
TURTI	GO:0004842	ubiquitin-protein transferase activity	Extinctions
TURTI	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
TURTI	GO:0003824	catalytic activity	Extinctions
TURTI	GO:0005509	calcium ion binding	Extinctions
TURTI	GO:0003678	DNA helicase activity	Extinctions
TURTI	GO:0009975	cyclase activity	Extinctions
TURTI	GO:0004683	calmodulin-dependent protein kinase activity	Extinctions
OABIE	GO:0003676	nucleic acid binding	Gains
OABIE	GO:1901363	heterocyclic compound binding	Gains
OABIE	GO:0097159	organic cyclic compound binding	Gains
OABIE	GO:0003964	RNA-directed DNA polymerase activity	Gains
OABIE	GO:0034061	DNA polymerase activity	Gains
OABIE	GO:0140097	catalytic activity, acting on DNA	Gains
OABIE	GO:0004872	receptor activity	Gains
OABIE	GO:0060089	molecular transducer activity	Gains
OABIE	GO:0099600	transmembrane receptor activity	Gains
OABIE	GO:0004930	G-protein coupled receptor activity	Gains
OABIE	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
OABIE	GO:0016917	GABA receptor activity	Gains
OABIE	GO:0016779	nucleotidyltransferase activity	Gains
OABIE	GO:0004672	protein kinase activity	Gains
OABIE	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
OABIE	GO:0004692	cGMP-dependent protein kinase activity	Gains
OABIE	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
OABIE	GO:0004888	transmembrane signaling receptor activity	Gains
OABIE	GO:0038023	signaling receptor activity	Gains
OABIE	GO:0004871	signal transducer activity	Gains
OABIE	GO:0004674	protein serine/threonine kinase activity	Gains
OABIE	GO:0015276	ligand-gated ion channel activity	Gains
OABIE	GO:0022834	ligand-gated channel activity	Gains
OABIE	GO:0004965	G-protein coupled GABA receptor activity	Gains
OABIE	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
OABIE	GO:0022836	gated channel activity	Gains
OABIE	GO:0097109	neuroligin family protein binding	Gains
OABIE	GO:0015250	water channel activity	Gains
OABIE	GO:0035175	histone kinase activity (H3-S10 specific)	Gains
OABIE	GO:0042654	ecdysis-triggering hormone receptor activity	Gains
OABIE	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
OABIE	GO:0005372	water transmembrane transporter activity	Gains
OABIE	GO:0004997	thyrotropin-releasing hormone receptor activity	Gains
OABIE	GO:0008446	GDP-mannose 4,6-dehydratase activity	Gains
OABIE	GO:0017050	D-erythro-sphingosine kinase activity	Gains
OABIE	GO:0043855	cyclic nucleotide-gated ion channel activity	Gains
OABIE	GO:0034185	apolipoprotein binding	Gains
OABIE	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Gains
OABIE	GO:0004352	glutamate dehydrogenase (NAD+) activity	Gains
OABIE	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Gains
OABIE	GO:0004356	glutamate-ammonia ligase activity	Gains
OABIE	GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity	Gains
OABIE	GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	Gains
OABIE	GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity	Gains
OABIE	GO:0030350	iron-responsive element binding	Gains
OABIE	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Gains
OABIE	GO:0005222	intracellular cAMP activated cation channel activity	Gains
OABIE	GO:0005223	intracellular cGMP activated cation channel activity	Gains
OABIE	GO:0016211	ammonia ligase activity	Gains
OABIE	GO:0060072	large conductance calcium-activated potassium channel activity	Gains
OABIE	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Gains
OABIE	GO:0003973	(S)-2-hydroxy-acid oxidase activity	Gains
OABIE	GO:0042736	NADH kinase activity	Gains
OABIE	GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
OABIE	GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	Gains
OABIE	GO:1990939	ATP-dependent microtubule motor activity	Gains
OABIE	GO:0005230	extracellular ligand-gated ion channel activity	Gains
OABIE	GO:0016491	oxidoreductase activity	Losses
OABIE	GO:0005215	transporter activity	Losses
OABIE	GO:0004312	fatty acid synthase activity	Losses
OABIE	GO:0022857	transmembrane transporter activity	Losses
OABIE	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
OABIE	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
OABIE	GO:0042302	structural constituent of cuticle	Losses
OABIE	GO:0005549	odorant binding	Losses
OABIE	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
OABIE	GO:0004984	olfactory receptor activity	Losses
OABIE	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
OABIE	GO:0070330	aromatase activity	Losses
OABIE	GO:0048018	receptor ligand activity	Losses
OABIE	GO:0099600	transmembrane receptor activity	Losses
OABIE	GO:0004930	G-protein coupled receptor activity	Losses
OABIE	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
OABIE	GO:0004888	transmembrane signaling receptor activity	Losses
OABIE	GO:0020037	heme binding	Losses
OABIE	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
OABIE	GO:0005214	structural constituent of chitin-based cuticle	Losses
OABIE	GO:0046906	tetrapyrrole binding	Losses
OABIE	GO:0030545	receptor regulator activity	Losses
OABIE	GO:0004497	monooxygenase activity	Losses
OABIE	GO:0016803	ether hydrolase activity	Losses
OABIE	GO:0042834	peptidoglycan binding	Losses
OABIE	GO:0003730	mRNA 3'-UTR binding	Losses
OABIE	GO:0004872	receptor activity	Losses
OABIE	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
OABIE	GO:0050591	quinine 3-monooxygenase activity	Losses
OABIE	GO:0018685	alkane 1-monooxygenase activity	Losses
OABIE	GO:0035586	purinergic receptor activity	Losses
OABIE	GO:0004470	malic enzyme activity	Losses
OABIE	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Losses
OABIE	GO:0009922	fatty acid elongase activity	Losses
OABIE	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Losses
OABIE	GO:0018454	acetoacetyl-CoA reductase activity	Losses
OABIE	GO:0004501	ecdysone 20-monooxygenase activity	Losses
OABIE	GO:0038023	signaling receptor activity	Losses
OABIE	GO:0042910	xenobiotic transmembrane transporter activity	Losses
OABIE	GO:0140104	molecular carrier activity	Losses
OABIE	GO:0015645	fatty acid ligase activity	Losses
OABIE	GO:0004467	long-chain fatty acid-CoA ligase activity	Losses
OABIE	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
OABIE	GO:0030291	protein serine/threonine kinase inhibitor activity	Losses
OABIE	GO:0060089	molecular transducer activity	Losses
OABIE	GO:0005184	neuropeptide hormone activity	Losses
OABIE	GO:0004860	protein kinase inhibitor activity	Losses
OABIE	GO:0019210	kinase inhibitor activity	Losses
OABIE	GO:0008028	monocarboxylic acid transmembrane transporter activity	Losses
OABIE	GO:0004602	glutathione peroxidase activity	Losses
OABIE	GO:0015238	drug transmembrane transporter activity	Losses
OABIE	GO:0090484	drug transporter activity	Losses
OABIE	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
OABIE	GO:0004601	peroxidase activity	Losses
OABIE	GO:0005344	oxygen carrier activity	Losses
OABIE	GO:0004463	leukotriene-A4 hydrolase activity	Losses
OABIE	GO:0005179	hormone activity	Losses
OABIE	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
OABIE	GO:0008395	steroid hydroxylase activity	Losses
OABIE	GO:0004089	carbonate dehydratase activity	Losses
OABIE	GO:1901682	sulfur compound transmembrane transporter activity	Losses
OABIE	GO:0016801	hydrolase activity, acting on ether bonds	Losses
OABIE	GO:0022891	substrate-specific transmembrane transporter activity	Losses
OABIE	GO:0016298	lipase activity	Losses
OABIE	GO:0019992	diacylglycerol binding	Losses
OABIE	GO:0016015	morphogen activity	Losses
OABIE	GO:0004620	phospholipase activity	Losses
OABIE	GO:0005506	iron ion binding	Losses
OABIE	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
OABIE	GO:0008238	exopeptidase activity	Losses
OABIE	GO:0019842	vitamin binding	Losses
OABIE	GO:0004857	enzyme inhibitor activity	Losses
OABIE	GO:0022892	substrate-specific transporter activity	Losses
OABIE	GO:0015605	organophosphate ester transmembrane transporter activity	Losses
OABIE	GO:0048018	receptor ligand activity	Extinctions
OABIE	GO:0005549	odorant binding	Extinctions
OABIE	GO:0035586	purinergic receptor activity	Extinctions
OABIE	GO:0018454	acetoacetyl-CoA reductase activity	Extinctions
OABIE	GO:0140104	molecular carrier activity	Extinctions
OABIE	GO:0005184	neuropeptide hormone activity	Extinctions
OABIE	GO:0030545	receptor regulator activity	Extinctions
OABIE	GO:0005179	hormone activity	Extinctions
OABIE	GO:0004984	olfactory receptor activity	Extinctions
OABIE	GO:0004089	carbonate dehydratase activity	Extinctions
OABIE	GO:0005215	transporter activity	Extinctions
OABIE	GO:0005344	oxygen carrier activity	Extinctions
OABIE	GO:0004888	transmembrane signaling receptor activity	Extinctions
OABIE	GO:0099600	transmembrane receptor activity	Extinctions
OABIE	GO:0051213	dioxygenase activity	Extinctions
OABIE	GO:0004872	receptor activity	Extinctions
OABIE	GO:0022857	transmembrane transporter activity	Extinctions
OABIE	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
OABIE	GO:0005044	scavenger receptor activity	Extinctions
OABIE	GO:0060089	molecular transducer activity	Extinctions
OABIE	GO:0042834	peptidoglycan binding	Extinctions
OABIE	GO:0019825	oxygen binding	Extinctions
OABIE	GO:0004857	enzyme inhibitor activity	Extinctions
OABIE	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Extinctions
OABIE	GO:0004930	G-protein coupled receptor activity	Extinctions
OABIE	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Extinctions
OABIE	GO:0038024	cargo receptor activity	Extinctions
OABIE	GO:0038023	signaling receptor activity	Extinctions
OABIE	GO:0005343	organic acid:sodium symporter activity	Extinctions
OABIE	GO:0015645	fatty acid ligase activity	Extinctions
OABIE	GO:0004467	long-chain fatty acid-CoA ligase activity	Extinctions
OABIE	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
OABIE	GO:0030291	protein serine/threonine kinase inhibitor activity	Extinctions
OABIE	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
OABIE	GO:0051766	inositol trisphosphate kinase activity	Extinctions
OABIE	GO:0004129	cytochrome-c oxidase activity	Extinctions
OABIE	GO:0015002	heme-copper terminal oxidase activity	Extinctions
OABIE	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
OABIE	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
OABIE	GO:0016836	hydro-lyase activity	Extinctions
MDEST	GO:0140097	catalytic activity, acting on DNA	Gains
MDEST	GO:0003964	RNA-directed DNA polymerase activity	Gains
MDEST	GO:0005549	odorant binding	Gains
MDEST	GO:0004984	olfactory receptor activity	Gains
MDEST	GO:0034061	DNA polymerase activity	Gains
MDEST	GO:0003676	nucleic acid binding	Gains
MDEST	GO:0016779	nucleotidyltransferase activity	Gains
MDEST	GO:1901363	heterocyclic compound binding	Gains
MDEST	GO:0097159	organic cyclic compound binding	Gains
MDEST	GO:0003677	DNA binding	Gains
MDEST	GO:0004190	aspartic-type endopeptidase activity	Gains
MDEST	GO:0070001	aspartic-type peptidase activity	Gains
MDEST	GO:0004930	G-protein coupled receptor activity	Gains
MDEST	GO:0003678	DNA helicase activity	Gains
MDEST	GO:0008270	zinc ion binding	Gains
MDEST	GO:0004871	signal transducer activity	Gains
MDEST	GO:0004888	transmembrane signaling receptor activity	Gains
MDEST	GO:0099600	transmembrane receptor activity	Gains
MDEST	GO:0000156	phosphorelay response regulator activity	Gains
MDEST	GO:0038023	signaling receptor activity	Gains
MDEST	GO:0046914	transition metal ion binding	Gains
MDEST	GO:0004803	transposase activity	Gains
MDEST	GO:0004872	receptor activity	Gains
MDEST	GO:0060089	molecular transducer activity	Gains
MDEST	GO:0016849	phosphorus-oxygen lyase activity	Gains
MDEST	GO:0046872	metal ion binding	Gains
MDEST	GO:0008094	DNA-dependent ATPase activity	Gains
MDEST	GO:0043169	cation binding	Gains
MDEST	GO:0004003	ATP-dependent DNA helicase activity	Gains
MDEST	GO:0004386	helicase activity	Gains
MDEST	GO:0005121	Toll binding	Gains
MDEST	GO:0005215	transporter activity	Gains
MDEST	GO:0015267	channel activity	Gains
MDEST	GO:0022803	passive transmembrane transporter activity	Gains
MDEST	GO:0004970	ionotropic glutamate receptor activity	Gains
MDEST	GO:0022824	transmitter-gated ion channel activity	Gains
MDEST	GO:0022835	transmitter-gated channel activity	Gains
MDEST	GO:0005216	ion channel activity	Gains
MDEST	GO:0043167	ion binding	Gains
MDEST	GO:0022838	substrate-specific channel activity	Gains
MDEST	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
MDEST	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
MDEST	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Gains
MDEST	GO:0043138	3'-5' DNA helicase activity	Gains
MDEST	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Gains
MDEST	GO:0003700	DNA binding transcription factor activity	Gains
MDEST	GO:0030594	neurotransmitter receptor activity	Gains
MDEST	GO:0004016	adenylate cyclase activity	Gains
MDEST	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
MDEST	GO:0008066	glutamate receptor activity	Gains
MDEST	GO:0004375	glycine dehydrogenase (decarboxylating) activity	Gains
MDEST	GO:0016151	nickel cation binding	Gains
MDEST	GO:0000403	Y-form DNA binding	Gains
MDEST	GO:0005518	collagen binding	Gains
MDEST	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	Gains
MDEST	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
MDEST	GO:0004516	nicotinate phosphoribosyltransferase activity	Gains
MDEST	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
MDEST	GO:0004644	phosphoribosylglycinamide formyltransferase activity	Gains
MDEST	GO:0019136	deoxynucleoside kinase activity	Gains
MDEST	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
MDEST	GO:0005230	extracellular ligand-gated ion channel activity	Gains
MDEST	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
MDEST	GO:0015276	ligand-gated ion channel activity	Gains
MDEST	GO:0022834	ligand-gated channel activity	Gains
MDEST	GO:0008238	exopeptidase activity	Losses
MDEST	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
MDEST	GO:0016805	dipeptidase activity	Losses
MDEST	GO:0070330	aromatase activity	Losses
MDEST	GO:0004180	carboxypeptidase activity	Losses
MDEST	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
MDEST	GO:0005254	chloride channel activity	Losses
MDEST	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
MDEST	GO:0004602	glutathione peroxidase activity	Losses
MDEST	GO:0005253	anion channel activity	Losses
MDEST	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
MDEST	GO:0015108	chloride transmembrane transporter activity	Losses
MDEST	GO:0004497	monooxygenase activity	Losses
MDEST	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
MDEST	GO:0015103	inorganic anion transmembrane transporter activity	Losses
MDEST	GO:0008235	metalloexopeptidase activity	Losses
MDEST	GO:0015154	disaccharide transmembrane transporter activity	Losses
MDEST	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
MDEST	GO:0018685	alkane 1-monooxygenase activity	Losses
MDEST	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
MDEST	GO:0034481	chondroitin sulfotransferase activity	Losses
MDEST	GO:0016848	carbon-halide lyase activity	Losses
MDEST	GO:0050591	quinine 3-monooxygenase activity	Losses
MDEST	GO:0070405	ammonium ion binding	Losses
MDEST	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Losses
MDEST	GO:0005506	iron ion binding	Losses
MDEST	GO:0004364	glutathione transferase activity	Losses
MDEST	GO:0008236	serine-type peptidase activity	Losses
MDEST	GO:0017171	serine hydrolase activity	Losses
MDEST	GO:0048018	receptor ligand activity	Losses
MDEST	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
MDEST	GO:0016831	carboxy-lyase activity	Losses
MDEST	GO:0030145	manganese ion binding	Losses
MDEST	GO:0030545	receptor regulator activity	Losses
MDEST	GO:0008509	anion transmembrane transporter activity	Losses
MDEST	GO:0004040	amidase activity	Losses
MDEST	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Losses
MDEST	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
MDEST	GO:0004185	serine-type carboxypeptidase activity	Losses
MDEST	GO:0016882	cyclo-ligase activity	Losses
MDEST	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
MDEST	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
MDEST	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
MDEST	GO:0005184	neuropeptide hormone activity	Losses
MDEST	GO:0004568	chitinase activity	Losses
MDEST	GO:0008233	peptidase activity	Losses
MDEST	GO:0015144	carbohydrate transmembrane transporter activity	Losses
MDEST	GO:0051119	sugar transmembrane transporter activity	Losses
MDEST	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
MDEST	GO:0008061	chitin binding	Losses
MDEST	GO:0004312	fatty acid synthase activity	Losses
MDEST	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
MDEST	GO:0005487	nucleocytoplasmic transporter activity	Losses
MDEST	GO:0004322	ferroxidase activity	Losses
MDEST	GO:0016406	carnitine O-acyltransferase activity	Losses
MDEST	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
MDEST	GO:0070008	serine-type exopeptidase activity	Losses
MDEST	GO:0008613	diuretic hormone activity	Losses
MDEST	GO:0030170	pyridoxal phosphate binding	Losses
MDEST	GO:0070279	vitamin B6 binding	Losses
MDEST	GO:0003824	catalytic activity	Losses
MDEST	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
MDEST	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
MDEST	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
MDEST	GO:0016805	dipeptidase activity	Extinctions
MDEST	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Extinctions
MDEST	GO:0005184	neuropeptide hormone activity	Extinctions
MDEST	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Extinctions
MDEST	GO:0016882	cyclo-ligase activity	Extinctions
MDEST	GO:0048018	receptor ligand activity	Extinctions
MDEST	GO:0030545	receptor regulator activity	Extinctions
MDEST	GO:0005179	hormone activity	Extinctions
MDEST	GO:0005487	nucleocytoplasmic transporter activity	Extinctions
MDEST	GO:0004322	ferroxidase activity	Extinctions
MDEST	GO:0016406	carnitine O-acyltransferase activity	Extinctions
MDEST	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Extinctions
MDEST	GO:0008613	diuretic hormone activity	Extinctions
MDEST	GO:0008061	chitin binding	Extinctions
MDEST	GO:0001664	G-protein coupled receptor binding	Extinctions
MDEST	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Extinctions
MDEST	GO:0003714	transcription corepressor activity	Extinctions
MDEST	GO:0042826	histone deacetylase binding	Extinctions
MDEST	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Extinctions
MDEST	GO:0003951	NAD+ kinase activity	Extinctions
MDEST	GO:0008483	transaminase activity	Extinctions
MDEST	GO:0016769	transferase activity, transferring nitrogenous groups	Extinctions
MOCCI	GO:0003964	RNA-directed DNA polymerase activity	Gains
MOCCI	GO:0034061	DNA polymerase activity	Gains
MOCCI	GO:0016779	nucleotidyltransferase activity	Gains
MOCCI	GO:0070001	aspartic-type peptidase activity	Gains
MOCCI	GO:0004190	aspartic-type endopeptidase activity	Gains
MOCCI	GO:0140097	catalytic activity, acting on DNA	Gains
MOCCI	GO:0003676	nucleic acid binding	Gains
MOCCI	GO:0008270	zinc ion binding	Gains
MOCCI	GO:0003723	RNA binding	Gains
MOCCI	GO:0004984	olfactory receptor activity	Gains
MOCCI	GO:0008527	taste receptor activity	Gains
MOCCI	GO:0046914	transition metal ion binding	Gains
MOCCI	GO:0005549	odorant binding	Gains
MOCCI	GO:0003677	DNA binding	Gains
MOCCI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
MOCCI	GO:0004175	endopeptidase activity	Gains
MOCCI	GO:0097159	organic cyclic compound binding	Gains
MOCCI	GO:1901363	heterocyclic compound binding	Gains
MOCCI	GO:0032450	maltose alpha-glucosidase activity	Gains
MOCCI	GO:0035064	methylated histone binding	Gains
MOCCI	GO:0140030	modification-dependent protein binding	Gains
MOCCI	GO:0140034	methylation-dependent protein binding	Gains
MOCCI	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
MOCCI	GO:0008233	peptidase activity	Gains
MOCCI	GO:0042393	histone binding	Gains
MOCCI	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding	Gains
MOCCI	GO:0099600	transmembrane receptor activity	Gains
MOCCI	GO:0015276	ligand-gated ion channel activity	Gains
MOCCI	GO:0022834	ligand-gated channel activity	Gains
MOCCI	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
MOCCI	GO:0090599	alpha-glucosidase activity	Gains
MOCCI	GO:0005230	extracellular ligand-gated ion channel activity	Gains
MOCCI	GO:0004970	ionotropic glutamate receptor activity	Gains
MOCCI	GO:0022824	transmitter-gated ion channel activity	Gains
MOCCI	GO:0022835	transmitter-gated channel activity	Gains
MOCCI	GO:0008384	IkappaB kinase activity	Gains
MOCCI	GO:0016922	ligand-dependent nuclear receptor binding	Gains
MOCCI	GO:0004416	hydroxyacylglutathione hydrolase activity	Gains
MOCCI	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Gains
MOCCI	GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
MOCCI	GO:0004731	purine-nucleoside phosphorylase activity	Gains
MOCCI	GO:0004705	JUN kinase activity	Gains
MOCCI	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	Gains
MOCCI	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
MOCCI	GO:0016880	acid-ammonia (or amide) ligase activity	Gains
MOCCI	GO:0004645	phosphorylase activity	Gains
MOCCI	GO:0043958	acryloyl-CoA reductase activity	Gains
MOCCI	GO:0070548	L-glutamine aminotransferase activity	Gains
MOCCI	GO:0004519	endonuclease activity	Gains
MOCCI	GO:0005272	sodium channel activity	Gains
MOCCI	GO:0008307	structural constituent of muscle	Gains
MOCCI	GO:0016630	protochlorophyllide reductase activity	Gains
MOCCI	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
MOCCI	GO:0030594	neurotransmitter receptor activity	Gains
MOCCI	GO:0008066	glutamate receptor activity	Gains
MOCCI	GO:0015926	glucosidase activity	Gains
MOCCI	GO:0001104	RNA polymerase II transcription cofactor activity	Gains
MOCCI	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
MOCCI	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
MOCCI	GO:0060089	molecular transducer activity	Gains
MOCCI	GO:0004888	transmembrane signaling receptor activity	Gains
MOCCI	GO:0004707	MAP kinase activity	Gains
MOCCI	GO:0031409	pigment binding	Gains
MOCCI	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
MOCCI	GO:0016790	thiolester hydrolase activity	Gains
MOCCI	GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
MOCCI	GO:0004872	receptor activity	Losses
MOCCI	GO:0099600	transmembrane receptor activity	Losses
MOCCI	GO:0004930	G-protein coupled receptor activity	Losses
MOCCI	GO:0038023	signaling receptor activity	Losses
MOCCI	GO:0060089	molecular transducer activity	Losses
MOCCI	GO:0004888	transmembrane signaling receptor activity	Losses
MOCCI	GO:0004383	guanylate cyclase activity	Losses
MOCCI	GO:0004871	signal transducer activity	Losses
MOCCI	GO:0004713	protein tyrosine kinase activity	Losses
MOCCI	GO:0016849	phosphorus-oxygen lyase activity	Losses
MOCCI	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
MOCCI	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
MOCCI	GO:0004866	endopeptidase inhibitor activity	Losses
MOCCI	GO:0030414	peptidase inhibitor activity	Losses
MOCCI	GO:0050254	rhodopsin kinase activity	Losses
MOCCI	GO:0061135	endopeptidase regulator activity	Losses
MOCCI	GO:0004672	protein kinase activity	Losses
MOCCI	GO:0030246	carbohydrate binding	Losses
MOCCI	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
MOCCI	GO:0005509	calcium ion binding	Losses
MOCCI	GO:0008484	sulfuric ester hydrolase activity	Losses
MOCCI	GO:0004197	cysteine-type endopeptidase activity	Losses
MOCCI	GO:0009975	cyclase activity	Losses
MOCCI	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
MOCCI	GO:0015079	potassium ion transmembrane transporter activity	Losses
MOCCI	GO:0061134	peptidase regulator activity	Losses
MOCCI	GO:0016787	hydrolase activity	Losses
MOCCI	GO:0003960	NADPH:quinone reductase activity	Losses
MOCCI	GO:0004692	cGMP-dependent protein kinase activity	Losses
MOCCI	GO:0005267	potassium channel activity	Losses
MOCCI	GO:0008081	phosphoric diester hydrolase activity	Losses
MOCCI	GO:0017048	Rho GTPase binding	Losses
MOCCI	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
MOCCI	GO:0140096	catalytic activity, acting on a protein	Losses
MOCCI	GO:0016788	hydrolase activity, acting on ester bonds	Losses
MOCCI	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	Losses
MOCCI	GO:0015269	calcium-activated potassium channel activity	Losses
MOCCI	GO:0005227	calcium activated cation channel activity	Losses
MOCCI	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
MOCCI	GO:0003978	UDP-glucose 4-epimerase activity	Losses
MOCCI	GO:0033549	MAP kinase phosphatase activity	Losses
MOCCI	GO:0099106	ion channel regulator activity	Losses
MOCCI	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
MOCCI	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
MOCCI	GO:0022836	gated channel activity	Losses
MOCCI	GO:0019199	transmembrane receptor protein kinase activity	Losses
MOCCI	GO:0038024	cargo receptor activity	Losses
MOCCI	GO:0098772	molecular function regulator	Losses
MOCCI	GO:0015459	potassium channel regulator activity	Losses
MOCCI	GO:0004372	glycine hydroxymethyltransferase activity	Losses
MOCCI	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Losses
MOCCI	GO:0008890	glycine C-acetyltransferase activity	Losses
MOCCI	GO:0099095	ligand-gated anion channel activity	Losses
MOCCI	GO:0035312	5'-3' exodeoxyribonuclease activity	Losses
MOCCI	GO:0016286	small conductance calcium-activated potassium channel activity	Losses
MOCCI	GO:0031419	cobalamin binding	Losses
MOCCI	GO:0004806	triglyceride lipase activity	Losses
MOCCI	GO:0003951	NAD+ kinase activity	Losses
MOCCI	GO:0046906	tetrapyrrole binding	Losses
MOCCI	GO:0005215	transporter activity	Losses
MOCCI	GO:0005216	ion channel activity	Losses
MOCCI	GO:0004857	enzyme inhibitor activity	Losses
MOCCI	GO:0016301	kinase activity	Losses
MOCCI	GO:0005261	cation channel activity	Losses
MOCCI	GO:0022838	substrate-specific channel activity	Losses
MOCCI	GO:0008188	neuropeptide receptor activity	Losses
MOCCI	GO:0008171	O-methyltransferase activity	Losses
MOCCI	GO:0005044	scavenger receptor activity	Losses
MOCCI	GO:0043169	cation binding	Losses
MOCCI	GO:0016247	channel regulator activity	Losses
MOCCI	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Losses
MOCCI	GO:0022839	ion gated channel activity	Losses
MOCCI	GO:0046872	metal ion binding	Losses
MOCCI	GO:0008509	anion transmembrane transporter activity	Losses
MOCCI	GO:0015267	channel activity	Losses
MOCCI	GO:0022803	passive transmembrane transporter activity	Losses
MOCCI	GO:0004930	G-protein coupled receptor activity	Extinctions
MOCCI	GO:0008081	phosphoric diester hydrolase activity	Extinctions
MOCCI	GO:0008484	sulfuric ester hydrolase activity	Extinctions
MOCCI	GO:0004713	protein tyrosine kinase activity	Extinctions
MOCCI	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Extinctions
MOCCI	GO:0038023	signaling receptor activity	Extinctions
MOCCI	GO:0099600	transmembrane receptor activity	Extinctions
MOCCI	GO:0004888	transmembrane signaling receptor activity	Extinctions
MOCCI	GO:0015269	calcium-activated potassium channel activity	Extinctions
MOCCI	GO:0005227	calcium activated cation channel activity	Extinctions
MOCCI	GO:0003978	UDP-glucose 4-epimerase activity	Extinctions
MOCCI	GO:0099106	ion channel regulator activity	Extinctions
MOCCI	GO:0004872	receptor activity	Extinctions
MOCCI	GO:0004383	guanylate cyclase activity	Extinctions
MOCCI	GO:0015459	potassium channel regulator activity	Extinctions
MOCCI	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Extinctions
MOCCI	GO:0008890	glycine C-acetyltransferase activity	Extinctions
MOCCI	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
MOCCI	GO:0031419	cobalamin binding	Extinctions
MOCCI	GO:0016247	channel regulator activity	Extinctions
MOCCI	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Extinctions
MOCCI	GO:0022839	ion gated channel activity	Extinctions
MOCCI	GO:0004871	signal transducer activity	Extinctions
MOCCI	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
MOCCI	GO:0003960	NADPH:quinone reductase activity	Extinctions
MOCCI	GO:0060089	molecular transducer activity	Extinctions
MOCCI	GO:0005267	potassium channel activity	Extinctions
MOCCI	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
MOCCI	GO:0003951	NAD+ kinase activity	Extinctions
MOCCI	GO:0004197	cysteine-type endopeptidase activity	Extinctions
MOCCI	GO:0009975	cyclase activity	Extinctions
MOCCI	GO:0008106	alcohol dehydrogenase (NADP+) activity	Extinctions
MOCCI	GO:0004447	iodide peroxidase activity	Extinctions
MOCCI	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Extinctions
MOCCI	GO:0017056	structural constituent of nuclear pore	Extinctions
MOCCI	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Extinctions
MOCCI	GO:0016453	C-acetyltransferase activity	Extinctions
MOCCI	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	Extinctions
MOCCI	GO:0004657	proline dehydrogenase activity	Extinctions
MOCCI	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Extinctions
MOCCI	GO:0004064	arylesterase activity	Extinctions
MOCCI	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Extinctions
MOCCI	GO:0004033	aldo-keto reductase (NADP) activity	Extinctions
CSCUL	GO:0003964	RNA-directed DNA polymerase activity	Gains
CSCUL	GO:0140097	catalytic activity, acting on DNA	Gains
CSCUL	GO:0034061	DNA polymerase activity	Gains
CSCUL	GO:0030695	GTPase regulator activity	Gains
CSCUL	GO:0060589	nucleoside-triphosphatase regulator activity	Gains
CSCUL	GO:0003676	nucleic acid binding	Gains
CSCUL	GO:0005096	GTPase activator activity	Gains
CSCUL	GO:0022836	gated channel activity	Gains
CSCUL	GO:0046872	metal ion binding	Gains
CSCUL	GO:0008234	cysteine-type peptidase activity	Gains
CSCUL	GO:0043169	cation binding	Gains
CSCUL	GO:0005216	ion channel activity	Gains
CSCUL	GO:0022838	substrate-specific channel activity	Gains
CSCUL	GO:0015267	channel activity	Gains
CSCUL	GO:0022803	passive transmembrane transporter activity	Gains
CSCUL	GO:0003677	DNA binding	Gains
CSCUL	GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
CSCUL	GO:0005488	binding	Gains
CSCUL	GO:0016779	nucleotidyltransferase activity	Gains
CSCUL	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
CSCUL	GO:0008233	peptidase activity	Gains
CSCUL	GO:0004518	nuclease activity	Gains
CSCUL	GO:0004222	metalloendopeptidase activity	Gains
CSCUL	GO:0003678	DNA helicase activity	Gains
CSCUL	GO:0099600	transmembrane receptor activity	Gains
CSCUL	GO:0004175	endopeptidase activity	Gains
CSCUL	GO:0003777	microtubule motor activity	Gains
CSCUL	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
CSCUL	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
CSCUL	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
CSCUL	GO:0004629	phospholipase C activity	Gains
CSCUL	GO:0060089	molecular transducer activity	Gains
CSCUL	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
CSCUL	GO:0022832	voltage-gated channel activity	Gains
CSCUL	GO:0005244	voltage-gated ion channel activity	Gains
CSCUL	GO:0046914	transition metal ion binding	Gains
CSCUL	GO:0098772	molecular function regulator	Gains
CSCUL	GO:0015125	bile acid transmembrane transporter activity	Gains
CSCUL	GO:0005109	frizzled binding	Gains
CSCUL	GO:0008508	bile acid:sodium symporter activity	Gains
CSCUL	GO:0005319	lipid transporter activity	Gains
CSCUL	GO:0005262	calcium channel activity	Gains
CSCUL	GO:0097159	organic cyclic compound binding	Gains
CSCUL	GO:0030234	enzyme regulator activity	Gains
CSCUL	GO:1901363	heterocyclic compound binding	Gains
CSCUL	GO:0004871	signal transducer activity	Gains
CSCUL	GO:0004872	receptor activity	Gains
CSCUL	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
CSCUL	GO:0005261	cation channel activity	Gains
CSCUL	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
CSCUL	GO:0004888	transmembrane signaling receptor activity	Gains
CSCUL	GO:0004519	endonuclease activity	Gains
CSCUL	GO:0016787	hydrolase activity	Gains
CSCUL	GO:0004697	protein kinase C activity	Gains
CSCUL	GO:0038023	signaling receptor activity	Gains
CSCUL	GO:0030414	peptidase inhibitor activity	Gains
CSCUL	GO:0008270	zinc ion binding	Gains
CSCUL	GO:0019904	protein domain specific binding	Gains
CSCUL	GO:0004866	endopeptidase inhibitor activity	Gains
CSCUL	GO:0015276	ligand-gated ion channel activity	Gains
CSCUL	GO:0022834	ligand-gated channel activity	Gains
CSCUL	GO:0008092	cytoskeletal protein binding	Gains
CSCUL	GO:0004857	enzyme inhibitor activity	Gains
CSCUL	GO:0005102	receptor binding	Gains
CSCUL	GO:0008017	microtubule binding	Gains
CSCUL	GO:0003774	motor activity	Gains
CSCUL	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
CSCUL	GO:0004672	protein kinase activity	Gains
CSCUL	GO:0001664	G-protein coupled receptor binding	Gains
CSCUL	GO:0033868	Goodpasture-antigen-binding protein kinase activity	Gains
CSCUL	GO:0004342	glucosamine-6-phosphate deaminase activity	Gains
CSCUL	GO:0005178	integrin binding	Gains
CSCUL	GO:0005248	voltage-gated sodium channel activity	Gains
CSCUL	GO:0050113	inositol oxygenase activity	Gains
CSCUL	GO:1905030	voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential	Gains
CSCUL	GO:0004654	polyribonucleotide nucleotidyltransferase activity	Gains
CSCUL	GO:0016929	SUMO-specific protease activity	Gains
CSCUL	GO:0030594	neurotransmitter receptor activity	Gains
CSCUL	GO:0015075	ion transmembrane transporter activity	Gains
CSCUL	GO:0004190	aspartic-type endopeptidase activity	Gains
CSCUL	GO:0070001	aspartic-type peptidase activity	Gains
CSCUL	GO:0015296	anion:cation symporter activity	Gains
CSCUL	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Gains
CSCUL	GO:0016405	CoA-ligase activity	Gains
CSCUL	GO:0061135	endopeptidase regulator activity	Gains
CSCUL	GO:0015085	calcium ion transmembrane transporter activity	Gains
CSCUL	GO:0015631	tubulin binding	Gains
CSCUL	GO:0008236	serine-type peptidase activity	Gains
CSCUL	GO:0003682	chromatin binding	Gains
CSCUL	GO:0008199	ferric iron binding	Gains
CSCUL	GO:0051082	unfolded protein binding	Gains
CSCUL	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
CSCUL	GO:1901618	organic hydroxy compound transmembrane transporter activity	Gains
CSCUL	GO:0004835	tubulin-tyrosine ligase activity	Gains
CSCUL	GO:0003747	translation release factor activity	Gains
CSCUL	GO:0005245	voltage-gated calcium channel activity	Gains
CSCUL	GO:0008079	translation termination factor activity	Gains
CSCUL	GO:0097003	adipokinetic hormone receptor activity	Losses
CSCUL	GO:0097004	adipokinetic hormone binding	Losses
CSCUL	GO:0017046	peptide hormone binding	Losses
CSCUL	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
CSCUL	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Losses
CSCUL	GO:0008238	exopeptidase activity	Losses
CSCUL	GO:0042277	peptide binding	Losses
CSCUL	GO:0042834	peptidoglycan binding	Losses
CSCUL	GO:0042302	structural constituent of cuticle	Losses
CSCUL	GO:0005214	structural constituent of chitin-based cuticle	Losses
CSCUL	GO:0033218	amide binding	Losses
CSCUL	GO:0016500	protein-hormone receptor activity	Losses
CSCUL	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
CSCUL	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
CSCUL	GO:0004721	phosphoprotein phosphatase activity	Losses
CSCUL	GO:0016763	transferase activity, transferring pentosyl groups	Losses
CSCUL	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
CSCUL	GO:0042562	hormone binding	Losses
CSCUL	GO:0016746	transferase activity, transferring acyl groups	Losses
CSCUL	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Losses
CSCUL	GO:0005041	low-density lipoprotein receptor activity	Losses
CSCUL	GO:0042947	glucoside transmembrane transporter activity	Losses
CSCUL	GO:0004014	adenosylmethionine decarboxylase activity	Losses
CSCUL	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
CSCUL	GO:0004034	aldose 1-epimerase activity	Losses
CSCUL	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
CSCUL	GO:0032500	muramyl dipeptide binding	Losses
CSCUL	GO:0047980	hippurate hydrolase activity	Losses
CSCUL	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
CSCUL	GO:0015220	choline transmembrane transporter activity	Losses
CSCUL	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
CSCUL	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
CSCUL	GO:0050093	methanol dehydrogenase activity	Losses
CSCUL	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
CSCUL	GO:0004325	ferrochelatase activity	Losses
CSCUL	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
CSCUL	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
CSCUL	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
CSCUL	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
CSCUL	GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
CSCUL	GO:0015574	trehalose transmembrane transporter activity	Losses
CSCUL	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
CSCUL	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
CSCUL	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
CSCUL	GO:0035237	corazonin receptor activity	Losses
CSCUL	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
CSCUL	GO:0004146	dihydrofolate reductase activity	Losses
CSCUL	GO:0097493	structural molecule activity conferring elasticity	Losses
CSCUL	GO:0000404	heteroduplex DNA loop binding	Losses
CSCUL	GO:0000406	double-strand/single-strand DNA junction binding	Losses
CSCUL	GO:0008805	carbon-monoxide oxygenase activity	Losses
CSCUL	GO:0004793	threonine aldolase activity	Losses
CSCUL	GO:0004756	selenide, water dikinase activity	Losses
CSCUL	GO:0015098	molybdate ion transmembrane transporter activity	Losses
CSCUL	GO:0050111	mycocerosate synthase activity	Losses
CSCUL	GO:0004802	transketolase activity	Losses
CSCUL	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Losses
CSCUL	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Losses
CSCUL	GO:0050262	ribosylnicotinamide kinase activity	Losses
CSCUL	GO:0003984	acetolactate synthase activity	Losses
CSCUL	GO:0030586	[methionine synthase] reductase activity	Losses
CSCUL	GO:0003919	FMN adenylyltransferase activity	Losses
CSCUL	GO:0001875	lipopolysaccharide receptor activity	Losses
CSCUL	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
CSCUL	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
CSCUL	GO:0016019	peptidoglycan receptor activity	Losses
CSCUL	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Losses
CSCUL	GO:0016918	retinal binding	Losses
CSCUL	GO:0030983	mismatched DNA binding	Losses
CSCUL	GO:0016829	lyase activity	Losses
CSCUL	GO:0016830	carbon-carbon lyase activity	Losses
CSCUL	GO:0004180	carboxypeptidase activity	Losses
CSCUL	GO:0004312	fatty acid synthase activity	Losses
CSCUL	GO:0016791	phosphatase activity	Losses
CSCUL	GO:0003824	catalytic activity	Losses
CSCUL	GO:0004866	endopeptidase inhibitor activity	Losses
CSCUL	GO:0004040	amidase activity	Losses
CSCUL	GO:0015154	disaccharide transmembrane transporter activity	Losses
CSCUL	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
CSCUL	GO:0019788	NEDD8 transferase activity	Losses
CSCUL	GO:0008329	signaling pattern recognition receptor activity	Losses
CSCUL	GO:0038187	pattern recognition receptor activity	Losses
CSCUL	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
CSCUL	GO:0017018	myosin phosphatase activity	Losses
CSCUL	GO:0016420	malonyltransferase activity	Losses
CSCUL	GO:0016419	S-malonyltransferase activity	Losses
CSCUL	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
CSCUL	GO:0031386	protein tag	Losses
CSCUL	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Losses
CSCUL	GO:0004142	diacylglycerol cholinephosphotransferase activity	Losses
CSCUL	GO:0005212	structural constituent of eye lens	Losses
CSCUL	GO:0016781	phosphotransferase activity, paired acceptors	Losses
CSCUL	GO:0000403	Y-form DNA binding	Losses
CSCUL	GO:0030228	lipoprotein particle receptor activity	Losses
CSCUL	GO:0031208	POZ domain binding	Losses
CSCUL	GO:0004817	cysteine-tRNA ligase activity	Losses
CSCUL	GO:0008613	diuretic hormone activity	Losses
CSCUL	GO:0032135	DNA insertion or deletion binding	Losses
CSCUL	GO:0032137	guanine/thymine mispair binding	Losses
CSCUL	GO:0005501	retinoid binding	Losses
CSCUL	GO:0032138	single base insertion or deletion binding	Losses
CSCUL	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Losses
CSCUL	GO:0003913	DNA photolyase activity	Losses
CSCUL	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
CSCUL	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
CSCUL	GO:0050591	quinine 3-monooxygenase activity	Losses
CSCUL	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
CSCUL	GO:0061135	endopeptidase regulator activity	Losses
CSCUL	GO:0004869	cysteine-type endopeptidase inhibitor activity	Extinctions
CSCUL	GO:0005041	low-density lipoprotein receptor activity	Extinctions
CSCUL	GO:0004034	aldose 1-epimerase activity	Extinctions
CSCUL	GO:0032500	muramyl dipeptide binding	Extinctions
CSCUL	GO:0047980	hippurate hydrolase activity	Extinctions
CSCUL	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Extinctions
CSCUL	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
CSCUL	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Extinctions
CSCUL	GO:0050093	methanol dehydrogenase activity	Extinctions
CSCUL	GO:0004325	ferrochelatase activity	Extinctions
CSCUL	GO:0004446	inositol-hexakisphosphate phosphatase activity	Extinctions
CSCUL	GO:0035237	corazonin receptor activity	Extinctions
CSCUL	GO:0004146	dihydrofolate reductase activity	Extinctions
CSCUL	GO:0008805	carbon-monoxide oxygenase activity	Extinctions
CSCUL	GO:0004793	threonine aldolase activity	Extinctions
CSCUL	GO:0015098	molybdate ion transmembrane transporter activity	Extinctions
CSCUL	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Extinctions
CSCUL	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Extinctions
CSCUL	GO:0050262	ribosylnicotinamide kinase activity	Extinctions
CSCUL	GO:0003984	acetolactate synthase activity	Extinctions
CSCUL	GO:0030586	[methionine synthase] reductase activity	Extinctions
CSCUL	GO:0003919	FMN adenylyltransferase activity	Extinctions
CSCUL	GO:0001875	lipopolysaccharide receptor activity	Extinctions
CSCUL	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Extinctions
CSCUL	GO:0016019	peptidoglycan receptor activity	Extinctions
CSCUL	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Extinctions
CSCUL	GO:0016918	retinal binding	Extinctions
CSCUL	GO:0004866	endopeptidase inhibitor activity	Extinctions
CSCUL	GO:0061135	endopeptidase regulator activity	Extinctions
CSCUL	GO:0008238	exopeptidase activity	Extinctions
CSCUL	GO:0042277	peptide binding	Extinctions
CSCUL	GO:0030414	peptidase inhibitor activity	Extinctions
CSCUL	GO:0004040	amidase activity	Extinctions
CSCUL	GO:0019788	NEDD8 transferase activity	Extinctions
CSCUL	GO:0008329	signaling pattern recognition receptor activity	Extinctions
CSCUL	GO:0038187	pattern recognition receptor activity	Extinctions
CSCUL	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
CSCUL	GO:0097003	adipokinetic hormone receptor activity	Extinctions
CSCUL	GO:0097004	adipokinetic hormone binding	Extinctions
CSCUL	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Extinctions
CSCUL	GO:0004142	diacylglycerol cholinephosphotransferase activity	Extinctions
CSCUL	GO:0030228	lipoprotein particle receptor activity	Extinctions
CSCUL	GO:0031208	POZ domain binding	Extinctions
CSCUL	GO:0004817	cysteine-tRNA ligase activity	Extinctions
CSCUL	GO:0008613	diuretic hormone activity	Extinctions
CSCUL	GO:0005501	retinoid binding	Extinctions
CSCUL	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Extinctions
CSCUL	GO:0003913	DNA photolyase activity	Extinctions
CSCUL	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
CSCUL	GO:0050591	quinine 3-monooxygenase activity	Extinctions
CSCUL	GO:0033218	amide binding	Extinctions
CSCUL	GO:0061134	peptidase regulator activity	Extinctions
CSCUL	GO:0017046	peptide hormone binding	Extinctions
CSCUL	GO:0004307	ethanolaminephosphotransferase activity	Extinctions
CSCUL	GO:0004463	leukotriene-A4 hydrolase activity	Extinctions
CSCUL	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	Extinctions
CSCUL	GO:0003681	bent DNA binding	Extinctions
CSCUL	GO:0004814	arginine-tRNA ligase activity	Extinctions
CSCUL	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
CSCUL	GO:0048244	phytanoyl-CoA dioxygenase activity	Extinctions
HY27	GO:0005549	odorant binding	Gains
HY27	GO:0004984	olfactory receptor activity	Gains
HY27	GO:0016289	CoA hydrolase activity	Gains
HY27	GO:0003933	GTP cyclohydrolase activity	Gains
HY27	GO:0003934	GTP cyclohydrolase I activity	Gains
HY27	GO:0016801	hydrolase activity, acting on ether bonds	Gains
HY27	GO:0004364	glutathione transferase activity	Gains
HY27	GO:0004888	transmembrane signaling receptor activity	Gains
HY27	GO:0099600	transmembrane receptor activity	Gains
HY27	GO:0008329	signaling pattern recognition receptor activity	Gains
HY27	GO:0038187	pattern recognition receptor activity	Gains
HY27	GO:0004463	leukotriene-A4 hydrolase activity	Gains
HY27	GO:0038023	signaling receptor activity	Gains
HY27	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
HY27	GO:0008172	S-methyltransferase activity	Gains
HY27	GO:0019238	cyclohydrolase activity	Gains
HY27	GO:0004930	G-protein coupled receptor activity	Gains
HY27	GO:0004312	fatty acid synthase activity	Gains
HY27	GO:0016803	ether hydrolase activity	Gains
HY27	GO:0004872	receptor activity	Gains
HY27	GO:0016835	carbon-oxygen lyase activity	Gains
HY27	GO:0008276	protein methyltransferase activity	Gains
HY27	GO:0015293	symporter activity	Gains
HY27	GO:0008238	exopeptidase activity	Gains
HY27	GO:0016829	lyase activity	Gains
HY27	GO:0008237	metallopeptidase activity	Gains
HY27	GO:0015370	solute:sodium symporter activity	Gains
HY27	GO:0016209	antioxidant activity	Gains
HY27	GO:0004303	estradiol 17-beta-dehydrogenase activity	Gains
HY27	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
HY27	GO:0015645	fatty acid ligase activity	Gains
HY27	GO:0060089	molecular transducer activity	Gains
HY27	GO:0004602	glutathione peroxidase activity	Gains
HY27	GO:0008171	O-methyltransferase activity	Gains
HY27	GO:0004300	enoyl-CoA hydratase activity	Gains
HY27	GO:0008527	taste receptor activity	Gains
HY27	GO:0016836	hydro-lyase activity	Gains
HY27	GO:0005328	neurotransmitter:sodium symporter activity	Gains
HY27	GO:0005245	voltage-gated calcium channel activity	Gains
HY27	GO:0016783	sulfurtransferase activity	Gains
HY27	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Gains
HY27	GO:0004601	peroxidase activity	Gains
HY27	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
HY27	GO:0004634	phosphopyruvate hydratase activity	Gains
HY27	GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Gains
HY27	GO:0008331	high voltage-gated calcium channel activity	Gains
HY27	GO:0072542	protein phosphatase activator activity	Gains
HY27	GO:0042736	NADH kinase activity	Gains
HY27	GO:0005372	water transmembrane transporter activity	Gains
HY27	GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
HY27	GO:0008160	protein tyrosine phosphatase activator activity	Gains
HY27	GO:0005436	sodium:phosphate symporter activity	Gains
HY27	GO:0019211	phosphatase activator activity	Gains
HY27	GO:0009703	nitrate reductase (NADH) activity	Gains
HY27	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Gains
HY27	GO:0032500	muramyl dipeptide binding	Gains
HY27	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	Gains
HY27	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Gains
HY27	GO:0004352	glutamate dehydrogenase (NAD+) activity	Gains
HY27	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Gains
HY27	GO:0016019	peptidoglycan receptor activity	Gains
HY27	GO:0016034	maleylacetoacetate isomerase activity	Gains
HY27	GO:0004490	methylglutaconyl-CoA hydratase activity	Gains
HY27	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	Gains
HY27	GO:0047635	alanine-oxo-acid transaminase activity	Gains
HY27	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Gains
HY27	GO:0015250	water channel activity	Gains
HY27	GO:0004139	deoxyribose-phosphate aldolase activity	Gains
HY27	GO:0060308	GTP cyclohydrolase I regulator activity	Gains
HY27	GO:0047022	7-beta-hydroxysteroid dehydrogenase (NADP+) activity	Gains
HY27	GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	Gains
HY27	GO:0047035	testosterone dehydrogenase (NAD+) activity	Gains
HY27	GO:0018833	DDT-dehydrochlorinase activity	Gains
HY27	GO:0051721	protein phosphatase 2A binding	Gains
HY27	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Gains
HY27	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	Gains
HY27	GO:0071885	N-terminal protein N-methyltransferase activity	Gains
HY27	GO:0070259	tyrosyl-DNA phosphodiesterase activity	Gains
HY27	GO:0050221	prostaglandin-E2 9-reductase activity	Gains
HY27	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Gains
HY27	GO:0001875	lipopolysaccharide receptor activity	Gains
HY27	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Gains
HY27	GO:0046790	virion binding	Gains
HY27	GO:0003986	acetyl-CoA hydrolase activity	Gains
HY27	GO:0008020	G-protein coupled photoreceptor activity	Gains
HY27	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
HY27	GO:0004507	steroid 11-beta-monooxygenase activity	Gains
HY27	GO:0004667	prostaglandin-D synthase activity	Gains
HY27	GO:0034584	piRNA binding	Gains
HY27	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	Gains
HY27	GO:0008940	nitrate reductase activity	Gains
HY27	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
HY27	GO:0000062	fatty-acyl-CoA binding	Gains
HY27	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HY27	GO:1901567	fatty acid derivative binding	Gains
HY27	GO:0005262	calcium channel activity	Gains
HY27	GO:0015294	solute:cation symporter activity	Gains
HY27	GO:0061783	peptidoglycan muralytic activity	Gains
HY27	GO:0004177	aminopeptidase activity	Gains
HY27	GO:0008168	methyltransferase activity	Gains
HY27	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY27	GO:0034061	DNA polymerase activity	Losses
HY27	GO:0140097	catalytic activity, acting on DNA	Losses
HY27	GO:0016779	nucleotidyltransferase activity	Losses
HY27	GO:0070001	aspartic-type peptidase activity	Losses
HY27	GO:0004190	aspartic-type endopeptidase activity	Losses
HY27	GO:0003676	nucleic acid binding	Losses
HY27	GO:0046914	transition metal ion binding	Losses
HY27	GO:0008270	zinc ion binding	Losses
HY27	GO:0046872	metal ion binding	Losses
HY27	GO:0043169	cation binding	Losses
HY27	GO:0004175	endopeptidase activity	Losses
HY27	GO:1901363	heterocyclic compound binding	Losses
HY27	GO:0097159	organic cyclic compound binding	Losses
HY27	GO:0004501	ecdysone 20-monooxygenase activity	Losses
HY27	GO:0003723	RNA binding	Losses
HY27	GO:0005488	binding	Losses
HY27	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY27	GO:0008233	peptidase activity	Losses
HY27	GO:0003677	DNA binding	Losses
HY27	GO:0003713	transcription coactivator activity	Losses
HY27	GO:0004518	nuclease activity	Losses
HY27	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY27	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY27	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY27	GO:0016840	carbon-nitrogen lyase activity	Losses
HY27	GO:0003960	NADPH:quinone reductase activity	Losses
HY27	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
HY27	GO:0008395	steroid hydroxylase activity	Losses
HY27	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HY27	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY27	GO:0004984	olfactory receptor activity	Losses
HY27	GO:0004521	endoribonuclease activity	Losses
HY27	GO:0097109	neuroligin family protein binding	Losses
HY27	GO:0001614	purinergic nucleotide receptor activity	Losses
HY27	GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	Losses
HY27	GO:0004056	argininosuccinate lyase activity	Losses
HY27	GO:0042767	ecdysteroid 22-hydroxylase activity	Losses
HY27	GO:0016502	nucleotide receptor activity	Losses
HY27	GO:0044017	histone acetyltransferase activity (H3-K27 specific)	Losses
HY27	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
HY27	GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	Losses
HY27	GO:0030628	pre-mRNA 3'-splice site binding	Losses
HY27	GO:0047800	cysteamine dioxygenase activity	Losses
HY27	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY27	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
HY27	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
HY27	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
HY27	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
HY27	GO:0003720	telomerase activity	Losses
HY27	GO:0003721	telomerase RNA reverse transcriptase activity	Losses
HY27	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
HY27	GO:0002094	polyprenyltransferase activity	Losses
HY27	GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	Losses
HY27	GO:0004168	dolichol kinase activity	Losses
HY27	GO:0034185	apolipoprotein binding	Losses
HY27	GO:0004760	serine-pyruvate transaminase activity	Losses
HY27	GO:0050111	mycocerosate synthase activity	Losses
HY27	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY27	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY27	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
HY27	GO:0031752	D5 dopamine receptor binding	Losses
HY27	GO:0050780	dopamine receptor binding	Losses
HY27	GO:0043993	histone acetyltransferase activity (H3-K18 specific)	Losses
HY27	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
HY27	GO:0003682	chromatin binding	Losses
HY27	GO:0004222	metalloendopeptidase activity	Losses
HY27	GO:0005549	odorant binding	Losses
HY27	GO:0016843	amine-lyase activity	Losses
HY27	GO:0016844	strictosidine synthase activity	Losses
HY27	GO:0008453	alanine-glyoxylate transaminase activity	Losses
HY27	GO:0008140	cAMP response element binding protein binding	Losses
HY27	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
HY27	GO:0005212	structural constituent of eye lens	Losses
HY27	GO:0005242	inward rectifier potassium channel activity	Losses
HY27	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Losses
HY27	GO:0035258	steroid hormone receptor binding	Losses
HY27	GO:0016420	malonyltransferase activity	Losses
HY27	GO:0016419	S-malonyltransferase activity	Losses
HY27	GO:0035586	purinergic receptor activity	Losses
HY27	GO:0004823	leucine-tRNA ligase activity	Losses
HY27	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
HY27	GO:0043167	ion binding	Losses
HY27	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY27	GO:0034061	DNA polymerase activity	Extinctions
HY27	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY27	GO:0070001	aspartic-type peptidase activity	Extinctions
HY27	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY27	GO:0003713	transcription coactivator activity	Extinctions
HY27	GO:0003676	nucleic acid binding	Extinctions
HY27	GO:0001614	purinergic nucleotide receptor activity	Extinctions
HY27	GO:0004056	argininosuccinate lyase activity	Extinctions
HY27	GO:0016502	nucleotide receptor activity	Extinctions
HY27	GO:0003720	telomerase activity	Extinctions
HY27	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
HY27	GO:0004760	serine-pyruvate transaminase activity	Extinctions
HY27	GO:0004984	olfactory receptor activity	Extinctions
HY27	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
HY27	GO:0016779	nucleotidyltransferase activity	Extinctions
HY27	GO:0015002	heme-copper terminal oxidase activity	Extinctions
HY27	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
HY27	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
HY27	GO:0004129	cytochrome-c oxidase activity	Extinctions
HY27	GO:0008453	alanine-glyoxylate transaminase activity	Extinctions
HY27	GO:0035258	steroid hormone receptor binding	Extinctions
HY27	GO:0035586	purinergic receptor activity	Extinctions
HY27	GO:0004501	ecdysone 20-monooxygenase activity	Extinctions
HY27	GO:0005549	odorant binding	Extinctions
HY27	GO:0016842	amidine-lyase activity	Extinctions
HY27	GO:0051427	hormone receptor binding	Extinctions
HY27	GO:0035257	nuclear hormone receptor binding	Extinctions
HY27	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
HY27	GO:0030306	ADP-ribosylation factor binding	Extinctions
HY27	GO:0046914	transition metal ion binding	Extinctions
HY27	GO:1901677	phosphate transmembrane transporter activity	Extinctions
HY27	GO:0015114	phosphate ion transmembrane transporter activity	Extinctions
HY27	GO:0008270	zinc ion binding	Extinctions
25	GO:0004984	olfactory receptor activity	Gains
25	GO:0005549	odorant binding	Gains
25	GO:0004888	transmembrane signaling receptor activity	Gains
25	GO:0099600	transmembrane receptor activity	Gains
25	GO:0038023	signaling receptor activity	Gains
25	GO:0004930	G-protein coupled receptor activity	Gains
25	GO:0004871	signal transducer activity	Gains
25	GO:0004872	receptor activity	Gains
25	GO:0060089	molecular transducer activity	Gains
25	GO:0003964	RNA-directed DNA polymerase activity	Gains
25	GO:0008527	taste receptor activity	Gains
25	GO:0042302	structural constituent of cuticle	Gains
25	GO:0034061	DNA polymerase activity	Gains
25	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
25	GO:0004629	phospholipase C activity	Gains
25	GO:0005272	sodium channel activity	Gains
25	GO:0015267	channel activity	Gains
25	GO:0022803	passive transmembrane transporter activity	Gains
25	GO:0008233	peptidase activity	Gains
25	GO:0008237	metallopeptidase activity	Gains
25	GO:0022824	transmitter-gated ion channel activity	Gains
25	GO:0022835	transmitter-gated channel activity	Gains
25	GO:0004970	ionotropic glutamate receptor activity	Gains
25	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
25	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
25	GO:0004521	endoribonuclease activity	Gains
25	GO:0004222	metalloendopeptidase activity	Gains
25	GO:0005216	ion channel activity	Gains
25	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
25	GO:0022838	substrate-specific channel activity	Gains
25	GO:0004835	tubulin-tyrosine ligase activity	Gains
25	GO:0008066	glutamate receptor activity	Gains
25	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
25	GO:0022857	transmembrane transporter activity	Gains
25	GO:0005230	extracellular ligand-gated ion channel activity	Gains
25	GO:0016805	dipeptidase activity	Gains
25	GO:0008061	chitin binding	Gains
25	GO:0015081	sodium ion transmembrane transporter activity	Gains
25	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
25	GO:0004454	ketohexokinase activity	Gains
25	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
25	GO:0047536	2-aminoadipate transaminase activity	Gains
25	GO:0008887	glycerate kinase activity	Gains
25	GO:0008873	gluconate 2-dehydrogenase activity	Gains
25	GO:0008875	gluconate dehydrogenase activity	Gains
25	GO:0019811	cocaine binding	Gains
25	GO:0015222	serotonin transmembrane transporter activity	Gains
25	GO:0042943	D-amino acid transmembrane transporter activity	Gains
25	GO:0050093	methanol dehydrogenase activity	Gains
25	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
25	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Gains
25	GO:0008927	mannonate dehydratase activity	Gains
25	GO:0017159	pantetheine hydrolase activity	Gains
25	GO:0047485	protein N-terminus binding	Gains
25	GO:0004936	alpha-adrenergic receptor activity	Gains
25	GO:0004937	alpha1-adrenergic receptor activity	Gains
25	GO:0016618	hydroxypyruvate reductase activity	Gains
25	GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	Gains
25	GO:0005329	dopamine transmembrane transporter activity	Gains
25	GO:0005326	neurotransmitter transporter activity	Gains
25	GO:0003964	RNA-directed DNA polymerase activity	Losses
25	GO:0008238	exopeptidase activity	Losses
25	GO:0042302	structural constituent of cuticle	Losses
25	GO:0018685	alkane 1-monooxygenase activity	Losses
25	GO:0034061	DNA polymerase activity	Losses
25	GO:0017171	serine hydrolase activity	Losses
25	GO:0046914	transition metal ion binding	Losses
25	GO:0031409	pigment binding	Losses
25	GO:0004312	fatty acid synthase activity	Losses
25	GO:0004519	endonuclease activity	Losses
25	GO:0005506	iron ion binding	Losses
25	GO:0009922	fatty acid elongase activity	Losses
25	GO:0050113	inositol oxygenase activity	Losses
25	GO:0008236	serine-type peptidase activity	Losses
25	GO:0140097	catalytic activity, acting on DNA	Losses
25	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
25	GO:0016779	nucleotidyltransferase activity	Losses
25	GO:0004180	carboxypeptidase activity	Losses
25	GO:0008270	zinc ion binding	Losses
25	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
25	GO:0004252	serine-type endopeptidase activity	Losses
25	GO:0016229	steroid dehydrogenase activity	Losses
25	GO:0061134	peptidase regulator activity	Losses
25	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
25	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
25	GO:0008253	5'-nucleotidase activity	Losses
25	GO:0005154	epidermal growth factor receptor binding	Losses
25	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
25	GO:0030145	manganese ion binding	Losses
25	GO:0015171	amino acid transmembrane transporter activity	Losses
25	GO:0008233	peptidase activity	Losses
25	GO:0048037	cofactor binding	Losses
25	GO:0030246	carbohydrate binding	Losses
25	GO:0004344	glucose dehydrogenase activity	Losses
25	GO:0008812	choline dehydrogenase activity	Losses
25	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
25	GO:0030414	peptidase inhibitor activity	Losses
25	GO:0005201	extracellular matrix structural constituent	Losses
25	GO:0008514	organic anion transmembrane transporter activity	Losses
25	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
25	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
25	GO:0060089	molecular transducer activity	Losses
25	GO:0008252	nucleotidase activity	Losses
25	GO:0070330	aromatase activity	Losses
25	GO:0070851	growth factor receptor binding	Losses
25	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
25	GO:0004866	endopeptidase inhibitor activity	Losses
25	GO:0050662	coenzyme binding	Losses
25	GO:0005214	structural constituent of chitin-based cuticle	Losses
25	GO:0004352	glutamate dehydrogenase (NAD+) activity	Losses
25	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Losses
25	GO:0005471	ATP:ADP antiporter activity	Losses
25	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Losses
25	GO:1900750	oligopeptide binding	Losses
25	GO:0043295	glutathione binding	Losses
25	GO:0008798	beta-aspartyl-peptidase activity	Losses
25	GO:0030586	[methionine synthase] reductase activity	Losses
25	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	Losses
25	GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity	Losses
25	GO:0008746	NAD(P)+ transhydrogenase activity	Losses
25	GO:0004145	diamine N-acetyltransferase activity	Losses
25	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
25	GO:0004100	chitin synthase activity	Losses
25	GO:0008890	glycine C-acetyltransferase activity	Losses
25	GO:0015280	ligand-gated sodium channel activity	Losses
25	GO:0010314	phosphatidylinositol-5-phosphate binding	Losses
25	GO:0015217	ADP transmembrane transporter activity	Losses
25	GO:0008805	carbon-monoxide oxygenase activity	Losses
25	GO:0047635	alanine-oxo-acid transaminase activity	Losses
25	GO:0004796	thromboxane-A synthase activity	Losses
25	GO:0018833	DDT-dehydrochlorinase activity	Losses
25	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
25	GO:0052870	tocopherol omega-hydroxylase activity	Losses
25	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
25	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
25	GO:0004557	alpha-galactosidase activity	Losses
25	GO:0052692	raffinose alpha-galactosidase activity	Losses
25	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
25	GO:0044736	acid-sensing ion channel activity	Losses
25	GO:0003914	DNA (6-4) photolyase activity	Losses
25	GO:0035198	miRNA binding	Losses
25	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
25	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
25	GO:0050357	tropinesterase activity	Losses
25	GO:0004056	argininosuccinate lyase activity	Losses
25	GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Losses
25	GO:0050462	N-acetylneuraminate synthase activity	Losses
25	GO:0047444	N-acylneuraminate-9-phosphate synthase activity	Losses
25	GO:0042263	neuropeptide F receptor activity	Losses
25	GO:0008373	sialyltransferase activity	Losses
25	GO:0016652	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor	Losses
25	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Losses
25	GO:0070064	proline-rich region binding	Losses
25	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
25	GO:0047290	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	Losses
25	GO:0042736	NADH kinase activity	Losses
25	GO:0005347	ATP transmembrane transporter activity	Losses
25	GO:0061604	molybdopterin-synthase sulfurtransferase activity	Losses
25	GO:0061605	molybdopterin-synthase adenylyltransferase activity	Losses
25	GO:0008238	exopeptidase activity	Extinctions
25	GO:0050113	inositol oxygenase activity	Extinctions
25	GO:0008010	structural constituent of chitin-based larval cuticle	Extinctions
25	GO:0030145	manganese ion binding	Extinctions
25	GO:0008253	5'-nucleotidase activity	Extinctions
25	GO:0004344	glucose dehydrogenase activity	Extinctions
25	GO:0008812	choline dehydrogenase activity	Extinctions
25	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Extinctions
25	GO:0005214	structural constituent of chitin-based cuticle	Extinctions
25	GO:0008252	nucleotidase activity	Extinctions
25	GO:0031409	pigment binding	Extinctions
25	GO:0046914	transition metal ion binding	Extinctions
25	GO:0005506	iron ion binding	Extinctions
25	GO:0016805	dipeptidase activity	Extinctions
25	GO:1900750	oligopeptide binding	Extinctions
25	GO:0043295	glutathione binding	Extinctions
25	GO:0008798	beta-aspartyl-peptidase activity	Extinctions
25	GO:0030586	[methionine synthase] reductase activity	Extinctions
25	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	Extinctions
25	GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity	Extinctions
25	GO:0008746	NAD(P)+ transhydrogenase activity	Extinctions
25	GO:0004145	diamine N-acetyltransferase activity	Extinctions
25	GO:0015280	ligand-gated sodium channel activity	Extinctions
25	GO:0010314	phosphatidylinositol-5-phosphate binding	Extinctions
25	GO:0008805	carbon-monoxide oxygenase activity	Extinctions
25	GO:0044736	acid-sensing ion channel activity	Extinctions
25	GO:0004056	argininosuccinate lyase activity	Extinctions
25	GO:0050462	N-acetylneuraminate synthase activity	Extinctions
25	GO:0047444	N-acylneuraminate-9-phosphate synthase activity	Extinctions
25	GO:0042263	neuropeptide F receptor activity	Extinctions
25	GO:0008373	sialyltransferase activity	Extinctions
25	GO:0016652	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor	Extinctions
25	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Extinctions
25	GO:0070064	proline-rich region binding	Extinctions
25	GO:0047290	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	Extinctions
25	GO:0042736	NADH kinase activity	Extinctions
25	GO:0016886	ligase activity, forming phosphoric ester bonds	Extinctions
25	GO:0042302	structural constituent of cuticle	Extinctions
25	GO:0042826	histone deacetylase binding	Extinctions
25	GO:0000155	phosphorelay sensor kinase activity	Extinctions
25	GO:0004673	protein histidine kinase activity	Extinctions
HY25	GO:0004930	G-protein coupled receptor activity	Gains
HY25	GO:0099600	transmembrane receptor activity	Gains
HY25	GO:0004888	transmembrane signaling receptor activity	Gains
HY25	GO:0038023	signaling receptor activity	Gains
HY25	GO:0004872	receptor activity	Gains
HY25	GO:0004993	G-protein coupled serotonin receptor activity	Gains
HY25	GO:0099589	serotonin receptor activity	Gains
HY25	GO:0008227	G-protein coupled amine receptor activity	Gains
HY25	GO:0060089	molecular transducer activity	Gains
HY25	GO:0004871	signal transducer activity	Gains
HY25	GO:0004984	olfactory receptor activity	Gains
HY25	GO:0005506	iron ion binding	Gains
HY25	GO:0005549	odorant binding	Gains
HY25	GO:0004935	adrenergic receptor activity	Gains
HY25	GO:0004535	poly(A)-specific ribonuclease activity	Gains
HY25	GO:0008336	gamma-butyrobetaine dioxygenase activity	Gains
HY25	GO:0050221	prostaglandin-E2 9-reductase activity	Gains
HY25	GO:0004324	ferredoxin-NADP+ reductase activity	Gains
HY25	GO:0052722	fatty acid in-chain hydroxylase activity	Gains
HY25	GO:0008887	glycerate kinase activity	Gains
HY25	GO:0042586	peptide deformylase activity	Gains
HY25	GO:0001587	Gq/11-coupled serotonin receptor activity	Gains
HY25	GO:0050353	trimethyllysine dioxygenase activity	Gains
HY25	GO:0016618	hydroxypyruvate reductase activity	Gains
HY25	GO:0005031	tumor necrosis factor-activated receptor activity	Gains
HY25	GO:0005035	death receptor activity	Gains
HY25	GO:0000175	3'-5'-exoribonuclease activity	Gains
HY25	GO:0004312	fatty acid synthase activity	Gains
HY25	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
HY25	GO:0008237	metallopeptidase activity	Gains
HY25	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
HY25	GO:0043023	ribosomal large subunit binding	Gains
HY25	GO:0008260	3-oxoacid CoA-transferase activity	Gains
HY25	GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
HY25	GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
HY25	GO:0052834	inositol monophosphate phosphatase activity	Gains
HY25	GO:0008526	phosphatidylinositol transporter activity	Gains
HY25	GO:0004594	pantothenate kinase activity	Gains
HY25	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Gains
HY25	GO:0008967	phosphoglycolate phosphatase activity	Gains
HY25	GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
HY25	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY25	GO:0004532	exoribonuclease activity	Gains
HY25	GO:0005200	structural constituent of cytoskeleton	Gains
HY25	GO:0031406	carboxylic acid binding	Gains
HY25	GO:0043177	organic acid binding	Gains
HY25	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY25	GO:0034061	DNA polymerase activity	Losses
HY25	GO:0140097	catalytic activity, acting on DNA	Losses
HY25	GO:0016779	nucleotidyltransferase activity	Losses
HY25	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY25	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY25	GO:0004190	aspartic-type endopeptidase activity	Losses
HY25	GO:0070001	aspartic-type peptidase activity	Losses
HY25	GO:0003676	nucleic acid binding	Losses
HY25	GO:0004519	endonuclease activity	Losses
HY25	GO:0003723	RNA binding	Losses
HY25	GO:0004521	endoribonuclease activity	Losses
HY25	GO:0060089	molecular transducer activity	Losses
HY25	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY25	GO:0004872	receptor activity	Losses
HY25	GO:0004518	nuclease activity	Losses
HY25	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY25	GO:0038023	signaling receptor activity	Losses
HY25	GO:0004871	signal transducer activity	Losses
HY25	GO:0004540	ribonuclease activity	Losses
HY25	GO:0004984	olfactory receptor activity	Losses
HY25	GO:1901363	heterocyclic compound binding	Losses
HY25	GO:0097159	organic cyclic compound binding	Losses
HY25	GO:0004888	transmembrane signaling receptor activity	Losses
HY25	GO:0099600	transmembrane receptor activity	Losses
HY25	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
HY25	GO:0005549	odorant binding	Losses
HY25	GO:0008233	peptidase activity	Losses
HY25	GO:0004175	endopeptidase activity	Losses
HY25	GO:0046914	transition metal ion binding	Losses
HY25	GO:0030247	polysaccharide binding	Losses
HY25	GO:0001871	pattern binding	Losses
HY25	GO:0008270	zinc ion binding	Losses
HY25	GO:0016740	transferase activity	Losses
HY25	GO:0004970	ionotropic glutamate receptor activity	Losses
HY25	GO:0022824	transmitter-gated ion channel activity	Losses
HY25	GO:0022835	transmitter-gated channel activity	Losses
HY25	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
HY25	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY25	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Losses
HY25	GO:0045552	dihydrokaempferol 4-reductase activity	Losses
HY25	GO:0050277	sedoheptulokinase activity	Losses
HY25	GO:0047485	protein N-terminus binding	Losses
HY25	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Losses
HY25	GO:0005229	intracellular calcium activated chloride channel activity	Losses
HY25	GO:0003837	beta-ureidopropionase activity	Losses
HY25	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	Losses
HY25	GO:0070976	TIR domain binding	Losses
HY25	GO:0042768	ecdysteroid 2-hydroxylase activity	Losses
HY25	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Losses
HY25	GO:0004769	steroid delta-isomerase activity	Losses
HY25	GO:0015026	coreceptor activity	Losses
HY25	GO:0001586	Gi/o-coupled serotonin receptor activity	Losses
HY25	GO:0061778	intracellular chloride channel activity	Losses
HY25	GO:0033867	Fas-activated serine/threonine kinase activity	Losses
HY25	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
HY25	GO:0008066	glutamate receptor activity	Losses
HY25	GO:0005214	structural constituent of chitin-based cuticle	Losses
HY25	GO:0030414	peptidase inhibitor activity	Losses
HY25	GO:0030594	neurotransmitter receptor activity	Losses
HY25	GO:0004070	aspartate carbamoyltransferase activity	Losses
HY25	GO:0008379	thioredoxin peroxidase activity	Losses
HY25	GO:0070594	juvenile hormone response element binding	Losses
HY25	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Losses
HY25	GO:0005212	structural constituent of eye lens	Losses
HY25	GO:0016743	carboxyl- or carbamoyltransferase activity	Losses
HY25	GO:0004856	xylulokinase activity	Losses
HY25	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Losses
HY25	GO:0004555	alpha,alpha-trehalase activity	Losses
HY25	GO:0003997	acyl-CoA oxidase activity	Losses
HY25	GO:0015927	trehalase activity	Losses
HY25	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
HY25	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY25	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY25	GO:0034061	DNA polymerase activity	Extinctions
HY25	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY25	GO:0070001	aspartic-type peptidase activity	Extinctions
HY25	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY25	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
HY25	GO:0016779	nucleotidyltransferase activity	Extinctions
HY25	GO:0004984	olfactory receptor activity	Extinctions
HY25	GO:0003676	nucleic acid binding	Extinctions
HY25	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
HY25	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
HY25	GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
HY25	GO:0050277	sedoheptulokinase activity	Extinctions
HY25	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
HY25	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	Extinctions
HY25	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Extinctions
HY25	GO:0004769	steroid delta-isomerase activity	Extinctions
HY25	GO:0033867	Fas-activated serine/threonine kinase activity	Extinctions
HY25	GO:0005549	odorant binding	Extinctions
HY25	GO:0004871	signal transducer activity	Extinctions
HY25	GO:0004070	aspartate carbamoyltransferase activity	Extinctions
HY25	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Extinctions
HY25	GO:0016743	carboxyl- or carbamoyltransferase activity	Extinctions
HY25	GO:0004856	xylulokinase activity	Extinctions
HY25	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Extinctions
HY25	GO:0038023	signaling receptor activity	Extinctions
HY25	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY25	GO:0005346	purine ribonucleotide transmembrane transporter activity	Extinctions
HY25	GO:0015215	nucleotide transmembrane transporter activity	Extinctions
HY25	GO:0015216	purine nucleotide transmembrane transporter activity	Extinctions
HY25	GO:0000295	adenine nucleotide transmembrane transporter activity	Extinctions
HY25	GO:1901363	heterocyclic compound binding	Extinctions
HY25	GO:0097159	organic cyclic compound binding	Extinctions
HY23	GO:0005201	extracellular matrix structural constituent	Gains
HY23	GO:0042302	structural constituent of cuticle	Gains
HY23	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
HY23	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
HY23	GO:0097493	structural molecule activity conferring elasticity	Gains
HY23	GO:0070735	protein-glycine ligase activity	Gains
HY23	GO:0070736	protein-glycine ligase activity, initiating	Gains
HY23	GO:0070737	protein-glycine ligase activity, elongating	Gains
HY23	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Gains
HY23	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
HY23	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
HY23	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
HY23	GO:0005212	structural constituent of eye lens	Gains
HY23	GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
HY23	GO:0043539	protein serine/threonine kinase activator activity	Gains
HY23	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
HY23	GO:0004033	aldo-keto reductase (NADP) activity	Gains
HY23	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY23	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
HY23	GO:0004035	alkaline phosphatase activity	Gains
HY23	GO:0004190	aspartic-type endopeptidase activity	Gains
HY23	GO:0070001	aspartic-type peptidase activity	Gains
HY23	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HY23	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Gains
HY23	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Gains
HY23	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Gains
HY23	GO:0001786	phosphatidylserine binding	Gains
HY23	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
HY23	GO:0004619	phosphoglycerate mutase activity	Gains
HY23	GO:0034061	DNA polymerase activity	Gains
HY23	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HY23	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
HY23	GO:0030295	protein kinase activator activity	Gains
HY23	GO:0072341	modified amino acid binding	Gains
HY23	GO:0019209	kinase activator activity	Gains
HY23	GO:0008061	chitin binding	Gains
HY23	GO:0042578	phosphoric ester hydrolase activity	Gains
HY23	GO:0016791	phosphatase activity	Gains
HY23	GO:0015299	solute:proton antiporter activity	Gains
HY23	GO:0004835	tubulin-tyrosine ligase activity	Gains
HY23	GO:0001047	core promoter binding	Gains
HY23	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY23	GO:0034061	DNA polymerase activity	Losses
HY23	GO:0140097	catalytic activity, acting on DNA	Losses
HY23	GO:0016779	nucleotidyltransferase activity	Losses
HY23	GO:0005549	odorant binding	Losses
HY23	GO:0004803	transposase activity	Losses
HY23	GO:0004518	nuclease activity	Losses
HY23	GO:0004519	endonuclease activity	Losses
HY23	GO:0004190	aspartic-type endopeptidase activity	Losses
HY23	GO:0070001	aspartic-type peptidase activity	Losses
HY23	GO:0004984	olfactory receptor activity	Losses
HY23	GO:0003723	RNA binding	Losses
HY23	GO:0003676	nucleic acid binding	Losses
HY23	GO:0046872	metal ion binding	Losses
HY23	GO:0043169	cation binding	Losses
HY23	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY23	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY23	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY23	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY23	GO:0004521	endoribonuclease activity	Losses
HY23	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Losses
HY23	GO:0034185	apolipoprotein binding	Losses
HY23	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
HY23	GO:0005550	pheromone binding	Losses
HY23	GO:0050353	trimethyllysine dioxygenase activity	Losses
HY23	GO:0004734	pyrimidodiazepine synthase activity	Losses
HY23	GO:0016502	nucleotide receptor activity	Losses
HY23	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Losses
HY23	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Losses
HY23	GO:0001614	purinergic nucleotide receptor activity	Losses
HY23	GO:0097109	neuroligin family protein binding	Losses
HY23	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
HY23	GO:0008422	beta-glucosidase activity	Losses
HY23	GO:0008270	zinc ion binding	Losses
HY23	GO:0005488	binding	Losses
HY23	GO:0008233	peptidase activity	Losses
HY23	GO:0003677	DNA binding	Losses
HY23	GO:0046914	transition metal ion binding	Losses
HY23	GO:0070628	proteasome binding	Losses
HY23	GO:0017018	myosin phosphatase activity	Losses
HY23	GO:0035586	purinergic receptor activity	Losses
HY23	GO:0015037	peptide disulfide oxidoreductase activity	Losses
HY23	GO:0015038	glutathione disulfide oxidoreductase activity	Losses
HY23	GO:0004594	pantothenate kinase activity	Losses
HY23	GO:0004555	alpha,alpha-trehalase activity	Losses
HY23	GO:0015927	trehalase activity	Losses
HY23	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
HY23	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY23	GO:0004175	endopeptidase activity	Losses
HY23	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HY23	GO:0004540	ribonuclease activity	Losses
HY23	GO:0016454	C-palmitoyltransferase activity	Losses
HY23	GO:0004758	serine C-palmitoyltransferase activity	Losses
HY23	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
HY23	GO:0015439	heme-transporting ATPase activity	Losses
HY23	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
HY23	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
HY23	GO:0016209	antioxidant activity	Losses
HY23	GO:0015232	heme transporter activity	Losses
HY23	GO:0030955	potassium ion binding	Losses
HY23	GO:0031420	alkali metal ion binding	Losses
HY23	GO:0070006	metalloaminopeptidase activity	Losses
HY23	GO:0019992	diacylglycerol binding	Losses
HY23	GO:0008527	taste receptor activity	Losses
HY23	GO:0004774	succinate-CoA ligase activity	Losses
HY23	GO:0004775	succinate-CoA ligase (ADP-forming) activity	Losses
HY23	GO:0004743	pyruvate kinase activity	Losses
HY23	GO:0032182	ubiquitin-like protein binding	Losses
HY23	GO:0043130	ubiquitin binding	Losses
HY23	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY23	GO:0034061	DNA polymerase activity	Extinctions
HY23	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY23	GO:0016779	nucleotidyltransferase activity	Extinctions
HY23	GO:0004518	nuclease activity	Extinctions
HY23	GO:0005549	odorant binding	Extinctions
HY23	GO:0004519	endonuclease activity	Extinctions
HY23	GO:0003676	nucleic acid binding	Extinctions
HY23	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY23	GO:0070001	aspartic-type peptidase activity	Extinctions
HY23	GO:0046872	metal ion binding	Extinctions
HY23	GO:0043169	cation binding	Extinctions
HY23	GO:0003723	RNA binding	Extinctions
HY23	GO:0005550	pheromone binding	Extinctions
HY23	GO:0050353	trimethyllysine dioxygenase activity	Extinctions
HY23	GO:0016502	nucleotide receptor activity	Extinctions
HY23	GO:0001614	purinergic nucleotide receptor activity	Extinctions
HY23	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
HY23	GO:0070628	proteasome binding	Extinctions
HY23	GO:0035586	purinergic receptor activity	Extinctions
HY23	GO:0008233	peptidase activity	Extinctions
HY23	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
HY23	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
HY23	GO:0016454	C-palmitoyltransferase activity	Extinctions
HY23	GO:0004758	serine C-palmitoyltransferase activity	Extinctions
HY23	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
HY23	GO:0030955	potassium ion binding	Extinctions
HY23	GO:0031420	alkali metal ion binding	Extinctions
HY23	GO:0070006	metalloaminopeptidase activity	Extinctions
HY23	GO:0019992	diacylglycerol binding	Extinctions
HY23	GO:0004743	pyruvate kinase activity	Extinctions
HY23	GO:0032182	ubiquitin-like protein binding	Extinctions
HY23	GO:0043130	ubiquitin binding	Extinctions
HY23	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
HY23	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
HY23	GO:0004521	endoribonuclease activity	Extinctions
HY21	GO:0004984	olfactory receptor activity	Gains
HY21	GO:0005549	odorant binding	Gains
HY21	GO:0022843	voltage-gated cation channel activity	Gains
HY21	GO:0022832	voltage-gated channel activity	Gains
HY21	GO:0005244	voltage-gated ion channel activity	Gains
HY21	GO:0004888	transmembrane signaling receptor activity	Gains
HY21	GO:0004930	G-protein coupled receptor activity	Gains
HY21	GO:0004871	signal transducer activity	Gains
HY21	GO:0060072	large conductance calcium-activated potassium channel activity	Gains
HY21	GO:0001784	phosphotyrosine residue binding	Gains
HY21	GO:0045309	protein phosphorylated amino acid binding	Gains
HY21	GO:0016936	galactoside binding	Gains
HY21	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
HY21	GO:0004423	iduronate-2-sulfatase activity	Gains
HY21	GO:0099600	transmembrane receptor activity	Gains
HY21	GO:0005249	voltage-gated potassium channel activity	Gains
HY21	GO:0038023	signaling receptor activity	Gains
HY21	GO:0004657	proline dehydrogenase activity	Gains
HY21	GO:0008332	low voltage-gated calcium channel activity	Gains
HY21	GO:0008198	ferrous iron binding	Gains
HY21	GO:0030971	receptor tyrosine kinase binding	Gains
HY21	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding	Gains
HY21	GO:0008271	secondary active sulfate transmembrane transporter activity	Gains
HY21	GO:0004370	glycerol kinase activity	Gains
HY21	GO:1990782	protein tyrosine kinase binding	Gains
HY21	GO:0004102	choline O-acetyltransferase activity	Gains
HY21	GO:0060089	molecular transducer activity	Gains
HY21	GO:0051219	phosphoprotein binding	Gains
HY21	GO:0016929	SUMO-specific protease activity	Gains
HY21	GO:0015116	sulfate transmembrane transporter activity	Gains
HY21	GO:0016413	O-acetyltransferase activity	Gains
HY21	GO:0019900	kinase binding	Gains
HY21	GO:0008527	taste receptor activity	Gains
HY21	GO:0017110	nucleoside-diphosphatase activity	Gains
HY21	GO:0004738	pyruvate dehydrogenase activity	Gains
HY21	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Gains
HY21	GO:0004692	cGMP-dependent protein kinase activity	Gains
HY21	GO:0071855	neuropeptide receptor binding	Gains
HY21	GO:0045134	uridine-diphosphatase activity	Gains
HY21	GO:0043548	phosphatidylinositol 3-kinase binding	Gains
HY21	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HY21	GO:0005267	potassium channel activity	Gains
HY21	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Losses
HY21	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY21	GO:0034061	DNA polymerase activity	Losses
HY21	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Losses
HY21	GO:0005549	odorant binding	Losses
HY21	GO:0016779	nucleotidyltransferase activity	Losses
HY21	GO:0016860	intramolecular oxidoreductase activity	Losses
HY21	GO:0004521	endoribonuclease activity	Losses
HY21	GO:0004984	olfactory receptor activity	Losses
HY21	GO:0005506	iron ion binding	Losses
HY21	GO:0140097	catalytic activity, acting on DNA	Losses
HY21	GO:0046914	transition metal ion binding	Losses
HY21	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY21	GO:0004540	ribonuclease activity	Losses
HY21	GO:0004620	phospholipase activity	Losses
HY21	GO:0070001	aspartic-type peptidase activity	Losses
HY21	GO:0004190	aspartic-type endopeptidase activity	Losses
HY21	GO:0004518	nuclease activity	Losses
HY21	GO:0004796	thromboxane-A synthase activity	Losses
HY21	GO:0004667	prostaglandin-D synthase activity	Losses
HY21	GO:0016018	cyclosporin A binding	Losses
HY21	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
HY21	GO:0047886	farnesol dehydrogenase activity	Losses
HY21	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
HY21	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
HY21	GO:0008477	purine nucleosidase activity	Losses
HY21	GO:0033897	ribonuclease T2 activity	Losses
HY21	GO:0015574	trehalose transmembrane transporter activity	Losses
HY21	GO:0042947	glucoside transmembrane transporter activity	Losses
HY21	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Losses
HY21	GO:0003844	1,4-alpha-glucan branching enzyme activity	Losses
HY21	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Losses
HY21	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	Losses
HY21	GO:0003756	protein disulfide isomerase activity	Losses
HY21	GO:0004312	fatty acid synthase activity	Losses
HY21	GO:0005214	structural constituent of chitin-based cuticle	Losses
HY21	GO:0004519	endonuclease activity	Losses
HY21	GO:0016298	lipase activity	Losses
HY21	GO:0043169	cation binding	Losses
HY21	GO:0003676	nucleic acid binding	Losses
HY21	GO:0008270	zinc ion binding	Losses
HY21	GO:0043023	ribosomal large subunit binding	Losses
HY21	GO:0004776	succinate-CoA ligase (GDP-forming) activity	Losses
HY21	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
HY21	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Losses
HY21	GO:0015154	disaccharide transmembrane transporter activity	Losses
HY21	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
HY21	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
HY21	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
HY21	GO:0050833	pyruvate transmembrane transporter activity	Losses
HY21	GO:0050591	quinine 3-monooxygenase activity	Losses
HY21	GO:0005199	structural constituent of cell wall	Losses
HY21	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
HY21	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
HY21	GO:0052834	inositol monophosphate phosphatase activity	Losses
HY21	GO:0018685	alkane 1-monooxygenase activity	Losses
HY21	GO:0004470	malic enzyme activity	Losses
HY21	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Losses
HY21	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
HY21	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
HY21	GO:0004197	cysteine-type endopeptidase activity	Losses
HY21	GO:0046872	metal ion binding	Losses
HY21	GO:0051540	metal cluster binding	Losses
HY21	GO:0051536	iron-sulfur cluster binding	Losses
HY21	GO:0009922	fatty acid elongase activity	Losses
HY21	GO:0000213	tRNA-intron endonuclease activity	Losses
HY21	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
HY21	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
HY21	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
HY21	GO:0019992	diacylglycerol binding	Losses
HY21	GO:0016853	isomerase activity	Losses
HY21	GO:0051539	4 iron, 4 sulfur cluster binding	Losses
HY21	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Extinctions
HY21	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Extinctions
HY21	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY21	GO:0004521	endoribonuclease activity	Extinctions
HY21	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	Extinctions
HY21	GO:0003756	protein disulfide isomerase activity	Extinctions
HY21	GO:0034061	DNA polymerase activity	Extinctions
HY21	GO:0008477	purine nucleosidase activity	Extinctions
HY21	GO:0033897	ribonuclease T2 activity	Extinctions
HY21	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
HY21	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
HY21	GO:0004540	ribonuclease activity	Extinctions
HY21	GO:0004776	succinate-CoA ligase (GDP-forming) activity	Extinctions
HY21	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Extinctions
HY21	GO:0004519	endonuclease activity	Extinctions
HY21	GO:0004518	nuclease activity	Extinctions
HY21	GO:0005506	iron ion binding	Extinctions
HY21	GO:0000213	tRNA-intron endonuclease activity	Extinctions
HY21	GO:0019992	diacylglycerol binding	Extinctions
HY21	GO:0005549	odorant binding	Extinctions
HY21	GO:0030414	peptidase inhibitor activity	Extinctions
HY21	GO:0004774	succinate-CoA ligase activity	Extinctions
HY21	GO:0004775	succinate-CoA ligase (ADP-forming) activity	Extinctions
HY21	GO:0016860	intramolecular oxidoreductase activity	Extinctions
HY21	GO:0004767	sphingomyelin phosphodiesterase activity	Extinctions
HY21	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	Extinctions
HY21	GO:0061134	peptidase regulator activity	Extinctions
HY21	GO:0004047	aminomethyltransferase activity	Extinctions
HY21	GO:0008469	histone-arginine N-methyltransferase activity	Extinctions
HY21	GO:0016273	arginine N-methyltransferase activity	Extinctions
HY21	GO:0016274	protein-arginine N-methyltransferase activity	Extinctions
HY21	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Extinctions
HY29	GO:0034061	DNA polymerase activity	Gains
HY29	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY29	GO:0140097	catalytic activity, acting on DNA	Gains
HY29	GO:0016779	nucleotidyltransferase activity	Gains
HY29	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY29	GO:0004518	nuclease activity	Gains
HY29	GO:0004519	endonuclease activity	Gains
HY29	GO:0004190	aspartic-type endopeptidase activity	Gains
HY29	GO:0070001	aspartic-type peptidase activity	Gains
HY29	GO:0005080	protein kinase C binding	Gains
HY29	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HY29	GO:0050591	quinine 3-monooxygenase activity	Gains
HY29	GO:0005506	iron ion binding	Gains
HY29	GO:0038023	signaling receptor activity	Gains
HY29	GO:0046592	polyamine oxidase activity	Gains
HY29	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Gains
HY29	GO:0004984	olfactory receptor activity	Gains
HY29	GO:0099600	transmembrane receptor activity	Gains
HY29	GO:0004803	transposase activity	Gains
HY29	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY29	GO:0004872	receptor activity	Gains
HY29	GO:0060089	molecular transducer activity	Gains
HY29	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Gains
HY29	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
HY29	GO:0004888	transmembrane signaling receptor activity	Gains
HY29	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY29	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY29	GO:0004930	G-protein coupled receptor activity	Gains
HY29	GO:0003707	steroid hormone receptor activity	Gains
HY29	GO:0070330	aromatase activity	Gains
HY29	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HY29	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
HY29	GO:0005549	odorant binding	Gains
HY29	GO:0004965	G-protein coupled GABA receptor activity	Gains
HY29	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Gains
HY29	GO:0004521	endoribonuclease activity	Gains
HY29	GO:0042302	structural constituent of cuticle	Gains
HY29	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
HY29	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
HY29	GO:0004364	glutathione transferase activity	Gains
HY29	GO:0020037	heme binding	Gains
HY29	GO:0015151	alpha-glucoside transmembrane transporter activity	Gains
HY29	GO:0097493	structural molecule activity conferring elasticity	Gains
HY29	GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	Gains
HY29	GO:0015277	kainate selective glutamate receptor activity	Gains
HY29	GO:0042577	lipid phosphatase activity	Gains
HY29	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
HY29	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
HY29	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
HY29	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Gains
HY29	GO:0018833	DDT-dehydrochlorinase activity	Gains
HY29	GO:0035237	corazonin receptor activity	Gains
HY29	GO:0004995	tachykinin receptor activity	Gains
HY29	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
HY29	GO:0050232	putrescine oxidase activity	Gains
HY29	GO:0015574	trehalose transmembrane transporter activity	Gains
HY29	GO:0030366	molybdopterin synthase activity	Gains
HY29	GO:0042947	glucoside transmembrane transporter activity	Gains
HY29	GO:0004398	histidine decarboxylase activity	Gains
HY29	GO:0004373	glycogen (starch) synthase activity	Gains
HY29	GO:0004474	malate synthase activity	Gains
HY29	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
HY29	GO:0017151	DEAD/H-box RNA helicase binding	Gains
HY29	GO:0017159	pantetheine hydrolase activity	Gains
HY29	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
HY29	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
HY29	GO:0004796	thromboxane-A synthase activity	Gains
HY29	GO:0001222	transcription corepressor binding	Gains
HY29	GO:0001226	RNA polymerase II transcription corepressor binding	Gains
HY29	GO:0004734	pyrimidodiazepine synthase activity	Gains
HY29	GO:0004561	alpha-N-acetylglucosaminidase activity	Gains
HY29	GO:0046906	tetrapyrrole binding	Gains
HY29	GO:0016788	hydrolase activity, acting on ester bonds	Gains
HY29	GO:0016917	GABA receptor activity	Gains
HY29	GO:0016491	oxidoreductase activity	Gains
HY29	GO:0004871	signal transducer activity	Gains
HY29	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
HY29	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
HY29	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
HY29	GO:0005549	odorant binding	Losses
HY29	GO:0004984	olfactory receptor activity	Losses
HY29	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY29	GO:0034061	DNA polymerase activity	Losses
HY29	GO:0099600	transmembrane receptor activity	Losses
HY29	GO:0004888	transmembrane signaling receptor activity	Losses
HY29	GO:0038023	signaling receptor activity	Losses
HY29	GO:0004930	G-protein coupled receptor activity	Losses
HY29	GO:0140097	catalytic activity, acting on DNA	Losses
HY29	GO:0016779	nucleotidyltransferase activity	Losses
HY29	GO:0004872	receptor activity	Losses
HY29	GO:0008307	structural constituent of muscle	Losses
HY29	GO:0008241	peptidyl-dipeptidase activity	Losses
HY29	GO:0008239	dipeptidyl-peptidase activity	Losses
HY29	GO:0060089	molecular transducer activity	Losses
HY29	GO:0016278	lysine N-methyltransferase activity	Losses
HY29	GO:0016279	protein-lysine N-methyltransferase activity	Losses
HY29	GO:0018024	histone-lysine N-methyltransferase activity	Losses
HY29	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Losses
HY29	GO:0004871	signal transducer activity	Losses
HY29	GO:0042054	histone methyltransferase activity	Losses
HY29	GO:0080007	S-nitrosoglutathione reductase activity	Losses
HY29	GO:0005025	transforming growth factor beta receptor activity, type I	Losses
HY29	GO:0018271	biotin-protein ligase activity	Losses
HY29	GO:0004611	phosphoenolpyruvate carboxykinase activity	Losses
HY29	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Losses
HY29	GO:0050431	transforming growth factor beta binding	Losses
HY29	GO:0016361	activin receptor activity, type I	Losses
HY29	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Losses
HY29	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Losses
HY29	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Losses
HY29	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Losses
HY29	GO:0005125	cytokine activity	Losses
HY29	GO:0008747	N-acetylneuraminate lyase activity	Losses
HY29	GO:0016841	ammonia-lyase activity	Losses
HY29	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity	Losses
HY29	GO:0005550	pheromone binding	Losses
HY29	GO:0004794	L-threonine ammonia-lyase activity	Losses
HY29	GO:0004552	octanol dehydrogenase activity	Losses
HY29	GO:0008238	exopeptidase activity	Losses
HY29	GO:0005488	binding	Losses
HY29	GO:0008270	zinc ion binding	Losses
HY29	GO:0008170	N-methyltransferase activity	Losses
HY29	GO:0008237	metallopeptidase activity	Losses
HY29	GO:0008276	protein methyltransferase activity	Losses
HY29	GO:0004645	phosphorylase activity	Losses
HY29	GO:0048185	activin binding	Losses
HY29	GO:0046975	histone methyltransferase activity (H3-K36 specific)	Losses
HY29	GO:0035299	inositol pentakisphosphate 2-kinase activity	Losses
HY29	GO:0017018	myosin phosphatase activity	Losses
HY29	GO:0017002	activin-activated receptor activity	Losses
HY29	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Losses
HY29	GO:0016833	oxo-acid-lyase activity	Losses
HY29	GO:0016531	copper chaperone activity	Losses
HY29	GO:0008521	acetyl-CoA transporter activity	Losses
HY29	GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	Losses
HY29	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
HY29	GO:0004792	thiosulfate sulfurtransferase activity	Losses
HY29	GO:0004731	purine-nucleoside phosphorylase activity	Losses
HY29	GO:0004890	GABA-A receptor activity	Losses
HY29	GO:0046872	metal ion binding	Losses
HY29	GO:0043169	cation binding	Losses
HY29	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY29	GO:0005549	odorant binding	Extinctions
HY29	GO:0004984	olfactory receptor activity	Extinctions
HY29	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY29	GO:0034061	DNA polymerase activity	Extinctions
HY29	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Extinctions
HY29	GO:0005550	pheromone binding	Extinctions
HY29	GO:0004645	phosphorylase activity	Extinctions
HY29	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Extinctions
HY29	GO:0016531	copper chaperone activity	Extinctions
HY29	GO:0004792	thiosulfate sulfurtransferase activity	Extinctions
HY29	GO:0004731	purine-nucleoside phosphorylase activity	Extinctions
HY29	GO:0016530	metallochaperone activity	Extinctions
HY29	GO:0004930	G-protein coupled receptor activity	Extinctions
HY29	GO:0008241	peptidyl-dipeptidase activity	Extinctions
HY29	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Extinctions
EMEXI	GO:0003700	DNA binding transcription factor activity	Gains
EMEXI	GO:0140110	transcription regulator activity	Gains
EMEXI	GO:0019992	diacylglycerol binding	Gains
EMEXI	GO:0004372	glycine hydroxymethyltransferase activity	Gains
EMEXI	GO:0004930	G-protein coupled receptor activity	Gains
EMEXI	GO:0090079	translation regulator activity, nucleic acid binding	Gains
EMEXI	GO:0000900	translation repressor activity, nucleic acid binding	Gains
EMEXI	GO:0004190	aspartic-type endopeptidase activity	Gains
EMEXI	GO:0070001	aspartic-type peptidase activity	Gains
EMEXI	GO:0016832	aldehyde-lyase activity	Gains
EMEXI	GO:0004872	receptor activity	Gains
EMEXI	GO:0030371	translation repressor activity	Gains
EMEXI	GO:0038023	signaling receptor activity	Gains
EMEXI	GO:0045182	translation regulator activity	Gains
EMEXI	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
EMEXI	GO:0003730	mRNA 3'-UTR binding	Gains
EMEXI	GO:0043565	sequence-specific DNA binding	Gains
EMEXI	GO:0099600	transmembrane receptor activity	Gains
EMEXI	GO:0060089	molecular transducer activity	Gains
EMEXI	GO:0004550	nucleoside diphosphate kinase activity	Gains
EMEXI	GO:0008270	zinc ion binding	Gains
EMEXI	GO:0046914	transition metal ion binding	Gains
EMEXI	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
EMEXI	GO:0004871	signal transducer activity	Gains
EMEXI	GO:0004888	transmembrane signaling receptor activity	Gains
EMEXI	GO:0004935	adrenergic receptor activity	Gains
EMEXI	GO:0004359	glutaminase activity	Gains
EMEXI	GO:0047325	inositol tetrakisphosphate 1-kinase activity	Gains
EMEXI	GO:0005275	amine transmembrane transporter activity	Gains
EMEXI	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Gains
EMEXI	GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	Gains
EMEXI	GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	Gains
EMEXI	GO:0035368	selenocysteine insertion sequence binding	Gains
EMEXI	GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity	Gains
EMEXI	GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	Gains
EMEXI	GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity	Gains
EMEXI	GO:0018271	biotin-protein ligase activity	Gains
EMEXI	GO:0051011	microtubule minus-end binding	Gains
EMEXI	GO:0051018	protein kinase A binding	Gains
EMEXI	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	Gains
EMEXI	GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
EMEXI	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Gains
EMEXI	GO:0004735	pyrroline-5-carboxylate reductase activity	Gains
EMEXI	GO:0003973	(S)-2-hydroxy-acid oxidase activity	Gains
EMEXI	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
EMEXI	GO:0008999	ribosomal-protein-alanine N-acetyltransferase activity	Gains
EMEXI	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Gains
EMEXI	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Gains
EMEXI	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Gains
EMEXI	GO:0005009	insulin-activated receptor activity	Gains
EMEXI	GO:0033878	hormone-sensitive lipase activity	Gains
EMEXI	GO:0051425	PTB domain binding	Gains
EMEXI	GO:0034185	apolipoprotein binding	Gains
EMEXI	GO:0031151	histone methyltransferase activity (H3-K79 specific)	Gains
EMEXI	GO:0097109	neuroligin family protein binding	Gains
EMEXI	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Gains
EMEXI	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Gains
EMEXI	GO:0005368	taurine transmembrane transporter activity	Gains
EMEXI	GO:0005369	taurine:sodium symporter activity	Gains
EMEXI	GO:0043560	insulin receptor substrate binding	Gains
EMEXI	GO:0004019	adenylosuccinate synthase activity	Gains
EMEXI	GO:0043559	insulin binding	Gains
EMEXI	GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Gains
EMEXI	GO:0005430	synaptic vesicle amine transmembrane transporter activity	Gains
EMEXI	GO:0008117	sphinganine-1-phosphate aldolase activity	Gains
EMEXI	GO:0032454	histone demethylase activity (H3-K9 specific)	Gains
EMEXI	GO:0003964	RNA-directed DNA polymerase activity	Gains
EMEXI	GO:0008061	chitin binding	Losses
EMEXI	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
EMEXI	GO:0030247	polysaccharide binding	Losses
EMEXI	GO:0001871	pattern binding	Losses
EMEXI	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
EMEXI	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
EMEXI	GO:0004984	olfactory receptor activity	Losses
EMEXI	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
EMEXI	GO:0005549	odorant binding	Losses
EMEXI	GO:0009055	electron transfer activity	Losses
EMEXI	GO:0003964	RNA-directed DNA polymerase activity	Losses
EMEXI	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
EMEXI	GO:0016491	oxidoreductase activity	Losses
EMEXI	GO:0005214	structural constituent of chitin-based cuticle	Losses
EMEXI	GO:0008233	peptidase activity	Losses
EMEXI	GO:0038187	pattern recognition receptor activity	Losses
EMEXI	GO:0008329	signaling pattern recognition receptor activity	Losses
EMEXI	GO:0003954	NADH dehydrogenase activity	Losses
EMEXI	GO:0004175	endopeptidase activity	Losses
EMEXI	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
EMEXI	GO:0005215	transporter activity	Losses
EMEXI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
EMEXI	GO:0034061	DNA polymerase activity	Losses
EMEXI	GO:0008376	acetylgalactosaminyltransferase activity	Losses
EMEXI	GO:0019104	DNA N-glycosylase activity	Losses
EMEXI	GO:0004738	pyruvate dehydrogenase activity	Losses
EMEXI	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Losses
EMEXI	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Losses
EMEXI	GO:0016860	intramolecular oxidoreductase activity	Losses
EMEXI	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Losses
EMEXI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
EMEXI	GO:0060089	molecular transducer activity	Losses
EMEXI	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
EMEXI	GO:0003735	structural constituent of ribosome	Losses
EMEXI	GO:0008081	phosphoric diester hydrolase activity	Losses
EMEXI	GO:0022857	transmembrane transporter activity	Losses
EMEXI	GO:0004983	neuropeptide Y receptor activity	Losses
EMEXI	GO:0042834	peptidoglycan binding	Losses
EMEXI	GO:0004619	phosphoglycerate mutase activity	Losses
EMEXI	GO:0031409	pigment binding	Losses
EMEXI	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Losses
EMEXI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
EMEXI	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
EMEXI	GO:0004872	receptor activity	Losses
EMEXI	GO:0042302	structural constituent of cuticle	Losses
EMEXI	GO:0038024	cargo receptor activity	Losses
EMEXI	GO:0015035	protein disulfide oxidoreductase activity	Losses
EMEXI	GO:0016779	nucleotidyltransferase activity	Losses
EMEXI	GO:0004190	aspartic-type endopeptidase activity	Losses
EMEXI	GO:0070001	aspartic-type peptidase activity	Losses
EMEXI	GO:0070330	aromatase activity	Losses
EMEXI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
EMEXI	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
EMEXI	GO:0005201	extracellular matrix structural constituent	Losses
EMEXI	GO:0003723	RNA binding	Losses
EMEXI	GO:0001158	enhancer sequence-specific DNA binding	Losses
EMEXI	GO:0035326	enhancer binding	Losses
EMEXI	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
EMEXI	GO:0008061	chitin binding	Extinctions
EMEXI	GO:0003954	NADH dehydrogenase activity	Extinctions
EMEXI	GO:0004984	olfactory receptor activity	Extinctions
EMEXI	GO:0005549	odorant binding	Extinctions
EMEXI	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Extinctions
EMEXI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
EMEXI	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
EMEXI	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
EMEXI	GO:0004983	neuropeptide Y receptor activity	Extinctions
EMEXI	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
EMEXI	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
EMEXI	GO:0015035	protein disulfide oxidoreductase activity	Extinctions
EMEXI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
EMEXI	GO:0003735	structural constituent of ribosome	Extinctions
EMEXI	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
EMEXI	GO:0015036	disulfide oxidoreductase activity	Extinctions
EMEXI	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
EMEXI	GO:0034512	box C/D snoRNA binding	Extinctions
EMEXI	GO:0008725	DNA-3-methyladenine glycosylase activity	Extinctions
EMEXI	GO:0043916	DNA-7-methylguanine glycosylase activity	Extinctions
EMEXI	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
EMEXI	GO:0004170	dUTP diphosphatase activity	Extinctions
EMEXI	GO:0042284	sphingolipid delta-4 desaturase activity	Extinctions
EMEXI	GO:0052821	DNA-7-methyladenine glycosylase activity	Extinctions
EMEXI	GO:0052822	DNA-3-methylguanine glycosylase activity	Extinctions
EMEXI	GO:0005545	1-phosphatidylinositol binding	Extinctions
EMEXI	GO:0001735	prenylcysteine oxidase activity	Extinctions
EMEXI	GO:0004581	dolichyl-phosphate beta-glucosyltransferase activity	Extinctions
EMEXI	GO:0004512	inositol-3-phosphate synthase activity	Extinctions
EMEXI	GO:0046976	histone methyltransferase activity (H3-K27 specific)	Extinctions
EMEXI	GO:0005041	low-density lipoprotein receptor activity	Extinctions
EMEXI	GO:0003905	alkylbase DNA N-glycosylase activity	Extinctions
EMEXI	GO:0008903	hydroxypyruvate isomerase activity	Extinctions
EMEXI	GO:0035755	cardiolipin hydrolase activity	Extinctions
EMEXI	GO:0043733	DNA-3-methylbase glycosylase activity	Extinctions
EMEXI	GO:0042071	leucokinin receptor activity	Extinctions
EMEXI	GO:0004060	arylamine N-acetyltransferase activity	Extinctions
EMEXI	GO:0004059	aralkylamine N-acetyltransferase activity	Extinctions
EMEXI	GO:0004994	somatostatin receptor activity	Extinctions
EMEXI	GO:0016872	intramolecular lyase activity	Extinctions
EMEXI	GO:0004985	opioid receptor activity	Extinctions
EMEXI	GO:0034722	gamma-glutamyl-peptidase activity	Extinctions
EMEXI	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
EMEXI	GO:0004576	oligosaccharyl transferase activity	Extinctions
EMEXI	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
EMEXI	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
EMEXI	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
PBARB	GO:0003964	RNA-directed DNA polymerase activity	Gains
PBARB	GO:0004984	olfactory receptor activity	Gains
PBARB	GO:0005549	odorant binding	Gains
PBARB	GO:0060089	molecular transducer activity	Gains
PBARB	GO:0004872	receptor activity	Gains
PBARB	GO:0140097	catalytic activity, acting on DNA	Gains
PBARB	GO:0004871	signal transducer activity	Gains
PBARB	GO:0004888	transmembrane signaling receptor activity	Gains
PBARB	GO:0038023	signaling receptor activity	Gains
PBARB	GO:0034061	DNA polymerase activity	Gains
PBARB	GO:0099600	transmembrane receptor activity	Gains
PBARB	GO:0019199	transmembrane receptor protein kinase activity	Gains
PBARB	GO:0004930	G-protein coupled receptor activity	Gains
PBARB	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
PBARB	GO:0016286	small conductance calcium-activated potassium channel activity	Gains
PBARB	GO:0016779	nucleotidyltransferase activity	Gains
PBARB	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
PBARB	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
PBARB	GO:0005509	calcium ion binding	Gains
PBARB	GO:0050839	cell adhesion molecule binding	Gains
PBARB	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
PBARB	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
PBARB	GO:0005178	integrin binding	Gains
PBARB	GO:0003774	motor activity	Gains
PBARB	GO:0015081	sodium ion transmembrane transporter activity	Gains
PBARB	GO:0000403	Y-form DNA binding	Gains
PBARB	GO:0004519	endonuclease activity	Gains
PBARB	GO:0005044	scavenger receptor activity	Gains
PBARB	GO:0022890	inorganic cation transmembrane transporter activity	Gains
PBARB	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
PBARB	GO:0015269	calcium-activated potassium channel activity	Gains
PBARB	GO:0038024	cargo receptor activity	Gains
PBARB	GO:0015291	secondary active transmembrane transporter activity	Gains
PBARB	GO:0003777	microtubule motor activity	Gains
PBARB	GO:0005227	calcium activated cation channel activity	Gains
PBARB	GO:0004040	amidase activity	Gains
PBARB	GO:0050254	rhodopsin kinase activity	Gains
PBARB	GO:0004803	transposase activity	Gains
PBARB	GO:0004672	protein kinase activity	Gains
PBARB	GO:0005342	organic acid transmembrane transporter activity	Gains
PBARB	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
PBARB	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
PBARB	GO:0005328	neurotransmitter:sodium symporter activity	Gains
PBARB	GO:0022839	ion gated channel activity	Gains
PBARB	GO:0015491	cation:cation antiporter activity	Gains
PBARB	GO:0008324	cation transmembrane transporter activity	Gains
PBARB	GO:0004866	endopeptidase inhibitor activity	Gains
PBARB	GO:0015293	symporter activity	Gains
PBARB	GO:0016301	kinase activity	Gains
PBARB	GO:0005261	cation channel activity	Gains
PBARB	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
PBARB	GO:0015298	solute:cation antiporter activity	Gains
PBARB	GO:0030414	peptidase inhibitor activity	Gains
PBARB	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
PBARB	GO:0000217	DNA secondary structure binding	Gains
PBARB	GO:0015385	sodium:proton antiporter activity	Gains
PBARB	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
PBARB	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
PBARB	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
PBARB	GO:0061135	endopeptidase regulator activity	Gains
PBARB	GO:0140097	catalytic activity, acting on DNA	Losses
PBARB	GO:0003964	RNA-directed DNA polymerase activity	Losses
PBARB	GO:0034061	DNA polymerase activity	Losses
PBARB	GO:0016779	nucleotidyltransferase activity	Losses
PBARB	GO:0003676	nucleic acid binding	Losses
PBARB	GO:1901363	heterocyclic compound binding	Losses
PBARB	GO:0097159	organic cyclic compound binding	Losses
PBARB	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
PBARB	GO:0004190	aspartic-type endopeptidase activity	Losses
PBARB	GO:0070001	aspartic-type peptidase activity	Losses
PBARB	GO:0003677	DNA binding	Losses
PBARB	GO:0046914	transition metal ion binding	Losses
PBARB	GO:0008270	zinc ion binding	Losses
PBARB	GO:0004518	nuclease activity	Losses
PBARB	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
PBARB	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
PBARB	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
PBARB	GO:0003678	DNA helicase activity	Losses
PBARB	GO:0004175	endopeptidase activity	Losses
PBARB	GO:0004521	endoribonuclease activity	Losses
PBARB	GO:0004540	ribonuclease activity	Losses
PBARB	GO:0004803	transposase activity	Losses
PBARB	GO:0005488	binding	Losses
PBARB	GO:0046872	metal ion binding	Losses
PBARB	GO:0043169	cation binding	Losses
PBARB	GO:0016740	transferase activity	Losses
PBARB	GO:0003723	RNA binding	Losses
PBARB	GO:0004935	adrenergic receptor activity	Losses
PBARB	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
PBARB	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
PBARB	GO:0004519	endonuclease activity	Losses
PBARB	GO:0004020	adenylylsulfate kinase activity	Losses
PBARB	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
PBARB	GO:0071861	tachykinin receptor binding	Losses
PBARB	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
PBARB	GO:0050111	mycocerosate synthase activity	Losses
PBARB	GO:0070854	myosin VI heavy chain binding	Losses
PBARB	GO:0070855	myosin VI head/neck binding	Losses
PBARB	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
PBARB	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
PBARB	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
PBARB	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
PBARB	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
PBARB	GO:0005122	torso binding	Losses
PBARB	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
PBARB	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
PBARB	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
PBARB	GO:0030572	phosphatidyltransferase activity	Losses
PBARB	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Losses
PBARB	GO:0008808	cardiolipin synthase activity	Losses
PBARB	GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Losses
PBARB	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
PBARB	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
PBARB	GO:0018445	prothoracicotrophic hormone activity	Losses
PBARB	GO:0032028	myosin head/neck binding	Losses
PBARB	GO:0031489	myosin V binding	Losses
PBARB	GO:0050353	trimethyllysine dioxygenase activity	Losses
PBARB	GO:0015276	ligand-gated ion channel activity	Losses
PBARB	GO:0022834	ligand-gated channel activity	Losses
PBARB	GO:0008233	peptidase activity	Losses
PBARB	GO:0005184	neuropeptide hormone activity	Losses
PBARB	GO:0005201	extracellular matrix structural constituent	Losses
PBARB	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
PBARB	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
PBARB	GO:0003887	DNA-directed DNA polymerase activity	Losses
PBARB	GO:0008384	IkappaB kinase activity	Losses
PBARB	GO:0043023	ribosomal large subunit binding	Losses
PBARB	GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	Losses
PBARB	GO:0016420	malonyltransferase activity	Losses
PBARB	GO:0016419	S-malonyltransferase activity	Losses
PBARB	GO:0070853	myosin VI binding	Losses
PBARB	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
PBARB	GO:0008200	ion channel inhibitor activity	Losses
PBARB	GO:0016248	channel inhibitor activity	Losses
PBARB	GO:0005242	inward rectifier potassium channel activity	Losses
PBARB	GO:0047756	chondroitin 4-sulfotransferase activity	Losses
PBARB	GO:0050591	quinine 3-monooxygenase activity	Losses
PBARB	GO:0015927	trehalase activity	Losses
PBARB	GO:0004555	alpha,alpha-trehalase activity	Losses
PBARB	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
PBARB	GO:0035258	steroid hormone receptor binding	Losses
PBARB	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
PBARB	GO:0003954	NADH dehydrogenase activity	Losses
PBARB	GO:0004672	protein kinase activity	Losses
PBARB	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
PBARB	GO:0003676	nucleic acid binding	Extinctions
PBARB	GO:0140097	catalytic activity, acting on DNA	Extinctions
PBARB	GO:0034061	DNA polymerase activity	Extinctions
PBARB	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
PBARB	GO:1901363	heterocyclic compound binding	Extinctions
PBARB	GO:0097159	organic cyclic compound binding	Extinctions
PBARB	GO:0016779	nucleotidyltransferase activity	Extinctions
PBARB	GO:0003678	DNA helicase activity	Extinctions
PBARB	GO:0046914	transition metal ion binding	Extinctions
PBARB	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
PBARB	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
PBARB	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
PBARB	GO:0071861	tachykinin receptor binding	Extinctions
PBARB	GO:0005122	torso binding	Extinctions
PBARB	GO:0030572	phosphatidyltransferase activity	Extinctions
PBARB	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
PBARB	GO:0008808	cardiolipin synthase activity	Extinctions
PBARB	GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Extinctions
PBARB	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
PBARB	GO:0018445	prothoracicotrophic hormone activity	Extinctions
PBARB	GO:0050353	trimethyllysine dioxygenase activity	Extinctions
PBARB	GO:0005184	neuropeptide hormone activity	Extinctions
PBARB	GO:0005201	extracellular matrix structural constituent	Extinctions
PBARB	GO:0003954	NADH dehydrogenase activity	Extinctions
PBARB	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
PBARB	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
PBARB	GO:0005179	hormone activity	Extinctions
PBARB	GO:0004518	nuclease activity	Extinctions
PBARB	GO:0005506	iron ion binding	Extinctions
PBARB	GO:0008384	IkappaB kinase activity	Extinctions
PBARB	GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	Extinctions
PBARB	GO:0008200	ion channel inhibitor activity	Extinctions
PBARB	GO:0016248	channel inhibitor activity	Extinctions
PBARB	GO:0047756	chondroitin 4-sulfotransferase activity	Extinctions
PBARB	GO:0050591	quinine 3-monooxygenase activity	Extinctions
PBARB	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
PBARB	GO:0035258	steroid hormone receptor binding	Extinctions
PBARB	GO:0008270	zinc ion binding	Extinctions
PBARB	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
PBARB	GO:0004129	cytochrome-c oxidase activity	Extinctions
PBARB	GO:0015002	heme-copper terminal oxidase activity	Extinctions
PBARB	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
PBARB	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
PBARB	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Extinctions
PBARB	GO:0034481	chondroitin sulfotransferase activity	Extinctions
PBARB	GO:0035257	nuclear hormone receptor binding	Extinctions
PBARB	GO:0051427	hormone receptor binding	Extinctions
PBARB	GO:0015276	ligand-gated ion channel activity	Extinctions
PBARB	GO:0022834	ligand-gated channel activity	Extinctions
PBARB	GO:0003677	DNA binding	Extinctions
TPRET	GO:0003735	structural constituent of ribosome	Gains
TPRET	GO:0005198	structural molecule activity	Gains
TPRET	GO:0140098	catalytic activity, acting on RNA	Gains
TPRET	GO:0019843	rRNA binding	Gains
TPRET	GO:0097747	RNA polymerase activity	Gains
TPRET	GO:0034062	5'-3' RNA polymerase activity	Gains
TPRET	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
TPRET	GO:1901363	heterocyclic compound binding	Gains
TPRET	GO:0097159	organic cyclic compound binding	Gains
TPRET	GO:0004812	aminoacyl-tRNA ligase activity	Gains
TPRET	GO:0046423	allene-oxide cyclase activity	Gains
TPRET	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Gains
TPRET	GO:0003938	IMP dehydrogenase activity	Gains
TPRET	GO:0140101	catalytic activity, acting on a tRNA	Gains
TPRET	GO:0002161	aminoacyl-tRNA editing activity	Gains
TPRET	GO:0018454	acetoacetyl-CoA reductase activity	Gains
TPRET	GO:0003883	CTP synthase activity	Gains
TPRET	GO:0004823	leucine-tRNA ligase activity	Gains
TPRET	GO:0043021	ribonucleoprotein complex binding	Gains
TPRET	GO:0016433	rRNA (adenine) methyltransferase activity	Gains
TPRET	GO:0008378	galactosyltransferase activity	Gains
TPRET	GO:0010181	FMN binding	Gains
TPRET	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
TPRET	GO:0008173	RNA methyltransferase activity	Gains
TPRET	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	Gains
TPRET	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	Gains
TPRET	GO:0001105	RNA polymerase II transcription coactivator activity	Gains
TPRET	GO:0004658	propionyl-CoA carboxylase activity	Gains
TPRET	GO:0004386	helicase activity	Gains
TPRET	GO:0043022	ribosome binding	Gains
TPRET	GO:0140102	catalytic activity, acting on a rRNA	Gains
TPRET	GO:0008649	rRNA methyltransferase activity	Gains
TPRET	GO:0035250	UDP-galactosyltransferase activity	Gains
TPRET	GO:0004529	exodeoxyribonuclease activity	Gains
TPRET	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	Gains
TPRET	GO:0004527	exonuclease activity	Gains
TPRET	GO:0044877	macromolecular complex binding	Gains
TPRET	GO:0003964	RNA-directed DNA polymerase activity	Losses
TPRET	GO:0034061	DNA polymerase activity	Losses
TPRET	GO:0070001	aspartic-type peptidase activity	Losses
TPRET	GO:0004190	aspartic-type endopeptidase activity	Losses
TPRET	GO:0140097	catalytic activity, acting on DNA	Losses
TPRET	GO:0016779	nucleotidyltransferase activity	Losses
TPRET	GO:0003676	nucleic acid binding	Losses
TPRET	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
TPRET	GO:0046914	transition metal ion binding	Losses
TPRET	GO:0004519	endonuclease activity	Losses
TPRET	GO:0008270	zinc ion binding	Losses
TPRET	GO:0008233	peptidase activity	Losses
TPRET	GO:0004175	endopeptidase activity	Losses
TPRET	GO:0004518	nuclease activity	Losses
TPRET	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
TPRET	GO:0004521	endoribonuclease activity	Losses
TPRET	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
TPRET	GO:0004984	olfactory receptor activity	Losses
TPRET	GO:0046872	metal ion binding	Losses
TPRET	GO:0004540	ribonuclease activity	Losses
TPRET	GO:0043169	cation binding	Losses
TPRET	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
TPRET	GO:0005549	odorant binding	Losses
TPRET	GO:0003723	RNA binding	Losses
TPRET	GO:0004803	transposase activity	Losses
TPRET	GO:0005201	extracellular matrix structural constituent	Losses
TPRET	GO:0031127	alpha-(1,2)-fucosyltransferase activity	Losses
TPRET	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	Losses
TPRET	GO:0008200	ion channel inhibitor activity	Losses
TPRET	GO:0018685	alkane 1-monooxygenase activity	Losses
TPRET	GO:0016248	channel inhibitor activity	Losses
TPRET	GO:0016788	hydrolase activity, acting on ester bonds	Losses
TPRET	GO:0004000	adenosine deaminase activity	Losses
TPRET	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
TPRET	GO:1901363	heterocyclic compound binding	Losses
TPRET	GO:1901505	carbohydrate derivative transmembrane transporter activity	Losses
TPRET	GO:0097159	organic cyclic compound binding	Losses
TPRET	GO:0004857	enzyme inhibitor activity	Losses
TPRET	GO:0005488	binding	Losses
TPRET	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
TPRET	GO:0003677	DNA binding	Losses
TPRET	GO:0003678	DNA helicase activity	Losses
TPRET	GO:0005346	purine ribonucleotide transmembrane transporter activity	Losses
TPRET	GO:0008190	eukaryotic initiation factor 4E binding	Losses
TPRET	GO:0015215	nucleotide transmembrane transporter activity	Losses
TPRET	GO:0015216	purine nucleotide transmembrane transporter activity	Losses
TPRET	GO:0008527	taste receptor activity	Losses
TPRET	GO:0004736	pyruvate carboxylase activity	Losses
TPRET	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Losses
TPRET	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Losses
TPRET	GO:0003963	RNA-3'-phosphate cyclase activity	Losses
TPRET	GO:0000295	adenine nucleotide transmembrane transporter activity	Losses
TPRET	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
TPRET	GO:0008812	choline dehydrogenase activity	Losses
TPRET	GO:0019239	deaminase activity	Losses
TPRET	GO:0015291	secondary active transmembrane transporter activity	Losses
TPRET	GO:0038023	signaling receptor activity	Losses
TPRET	GO:0016787	hydrolase activity	Losses
TPRET	GO:0015002	heme-copper terminal oxidase activity	Losses
TPRET	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
TPRET	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
TPRET	GO:0004129	cytochrome-c oxidase activity	Losses
TPRET	GO:0004930	G-protein coupled receptor activity	Losses
TPRET	GO:0070001	aspartic-type peptidase activity	Extinctions
TPRET	GO:0004190	aspartic-type endopeptidase activity	Extinctions
TPRET	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
TPRET	GO:0034061	DNA polymerase activity	Extinctions
TPRET	GO:0140097	catalytic activity, acting on DNA	Extinctions
TPRET	GO:0003676	nucleic acid binding	Extinctions
TPRET	GO:0031127	alpha-(1,2)-fucosyltransferase activity	Extinctions
TPRET	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	Extinctions
TPRET	GO:0008200	ion channel inhibitor activity	Extinctions
TPRET	GO:0016248	channel inhibitor activity	Extinctions
TPRET	GO:0004984	olfactory receptor activity	Extinctions
TPRET	GO:0004175	endopeptidase activity	Extinctions
TPRET	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Extinctions
TPRET	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Extinctions
TPRET	GO:0099106	ion channel regulator activity	Extinctions
TPRET	GO:0008233	peptidase activity	Extinctions
TPRET	GO:0015002	heme-copper terminal oxidase activity	Extinctions
TPRET	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
TPRET	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
TPRET	GO:0004129	cytochrome-c oxidase activity	Extinctions
TPRET	GO:0016779	nucleotidyltransferase activity	Extinctions
TPRET	GO:0005549	odorant binding	Extinctions
TPRET	GO:0004930	G-protein coupled receptor activity	Extinctions
TPRET	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
PXYLO	GO:0000156	phosphorelay response regulator activity	Gains
PXYLO	GO:0004984	olfactory receptor activity	Gains
PXYLO	GO:0000155	phosphorelay sensor kinase activity	Gains
PXYLO	GO:0004673	protein histidine kinase activity	Gains
PXYLO	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
PXYLO	GO:0004930	G-protein coupled receptor activity	Gains
PXYLO	GO:0038023	signaling receptor activity	Gains
PXYLO	GO:0005549	odorant binding	Gains
PXYLO	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
PXYLO	GO:0008199	ferric iron binding	Gains
PXYLO	GO:0016722	oxidoreductase activity, oxidizing metal ions	Gains
PXYLO	GO:0016887	ATPase activity	Gains
PXYLO	GO:0004871	signal transducer activity	Gains
PXYLO	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
PXYLO	GO:0004872	receptor activity	Gains
PXYLO	GO:0005507	copper ion binding	Gains
PXYLO	GO:0010181	FMN binding	Gains
PXYLO	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
PXYLO	GO:0048037	cofactor binding	Gains
PXYLO	GO:0016462	pyrophosphatase activity	Gains
PXYLO	GO:0015278	calcium-release channel activity	Gains
PXYLO	GO:0016454	C-palmitoyltransferase activity	Gains
PXYLO	GO:0099604	ligand-gated calcium channel activity	Gains
PXYLO	GO:0004758	serine C-palmitoyltransferase activity	Gains
PXYLO	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
PXYLO	GO:0004654	polyribonucleotide nucleotidyltransferase activity	Gains
PXYLO	GO:0004655	porphobilinogen synthase activity	Gains
PXYLO	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	Gains
PXYLO	GO:0061783	peptidoglycan muralytic activity	Gains
PXYLO	GO:0005313	L-glutamate transmembrane transporter activity	Gains
PXYLO	GO:0015172	acidic amino acid transmembrane transporter activity	Gains
PXYLO	GO:0051287	NAD binding	Gains
PXYLO	GO:0004298	threonine-type endopeptidase activity	Gains
PXYLO	GO:0070003	threonine-type peptidase activity	Gains
PXYLO	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
PXYLO	GO:0099094	ligand-gated cation channel activity	Gains
PXYLO	GO:0004888	transmembrane signaling receptor activity	Gains
PXYLO	GO:0017111	nucleoside-triphosphatase activity	Gains
PXYLO	GO:0050662	coenzyme binding	Gains
PXYLO	GO:0035091	phosphatidylinositol binding	Gains
PXYLO	GO:0008238	exopeptidase activity	Gains
PXYLO	GO:0017016	Ras GTPase binding	Gains
PXYLO	GO:0022853	active ion transmembrane transporter activity	Gains
PXYLO	GO:0030145	manganese ion binding	Gains
PXYLO	GO:0046914	transition metal ion binding	Gains
PXYLO	GO:0060089	molecular transducer activity	Gains
PXYLO	GO:0042623	ATPase activity, coupled	Gains
PXYLO	GO:0051020	GTPase binding	Gains
PXYLO	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
PXYLO	GO:0003777	microtubule motor activity	Gains
PXYLO	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
PXYLO	GO:0031267	small GTPase binding	Gains
PXYLO	GO:0005215	transporter activity	Gains
PXYLO	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
PXYLO	GO:0008527	taste receptor activity	Gains
PXYLO	GO:0004180	carboxypeptidase activity	Gains
PXYLO	GO:0003735	structural constituent of ribosome	Losses
PXYLO	GO:0005198	structural molecule activity	Losses
PXYLO	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
PXYLO	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
PXYLO	GO:0004549	tRNA-specific ribonuclease activity	Losses
PXYLO	GO:0005214	structural constituent of chitin-based cuticle	Losses
PXYLO	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
PXYLO	GO:0019843	rRNA binding	Losses
PXYLO	GO:0003676	nucleic acid binding	Losses
PXYLO	GO:0008301	DNA binding, bending	Losses
PXYLO	GO:0003723	RNA binding	Losses
PXYLO	GO:0004568	chitinase activity	Losses
PXYLO	GO:0008134	transcription factor binding	Losses
PXYLO	GO:0003677	DNA binding	Losses
PXYLO	GO:0005484	SNAP receptor activity	Losses
PXYLO	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
PXYLO	GO:0004526	ribonuclease P activity	Losses
PXYLO	GO:0005515	protein binding	Losses
PXYLO	GO:0043565	sequence-specific DNA binding	Losses
PXYLO	GO:0140110	transcription regulator activity	Losses
PXYLO	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Losses
PXYLO	GO:0017040	ceramidase activity	Losses
PXYLO	GO:0005199	structural constituent of cell wall	Losses
PXYLO	GO:0046922	peptide-O-fucosyltransferase activity	Losses
PXYLO	GO:0004502	kynurenine 3-monooxygenase activity	Losses
PXYLO	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
PXYLO	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	Losses
PXYLO	GO:0004602	glutathione peroxidase activity	Losses
PXYLO	GO:0003746	translation elongation factor activity	Losses
PXYLO	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
PXYLO	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
PXYLO	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
PXYLO	GO:0019200	carbohydrate kinase activity	Losses
PXYLO	GO:0044212	transcription regulatory region DNA binding	Losses
PXYLO	GO:0003700	DNA binding transcription factor activity	Losses
PXYLO	GO:0070851	growth factor receptor binding	Losses
PXYLO	GO:0004659	prenyltransferase activity	Losses
PXYLO	GO:0001067	regulatory region nucleic acid binding	Losses
PXYLO	GO:0000975	regulatory region DNA binding	Losses
PXYLO	GO:0005102	receptor binding	Losses
PXYLO	GO:0008135	translation factor activity, RNA binding	Losses
PXYLO	GO:0070279	vitamin B6 binding	Losses
PXYLO	GO:0030170	pyridoxal phosphate binding	Losses
PXYLO	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
PXYLO	GO:0015926	glucosidase activity	Losses
PXYLO	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
PXYLO	GO:0004311	farnesyltranstransferase activity	Losses
PXYLO	GO:0005160	transforming growth factor beta receptor binding	Losses
PXYLO	GO:0004161	dimethylallyltranstransferase activity	Losses
PXYLO	GO:0070546	L-phenylalanine aminotransferase activity	Losses
PXYLO	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Losses
PXYLO	GO:0004738	pyruvate dehydrogenase activity	Losses
PXYLO	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Losses
PXYLO	GO:0000213	tRNA-intron endonuclease activity	Losses
PXYLO	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	Losses
PXYLO	GO:0009022	tRNA nucleotidyltransferase activity	Losses
PXYLO	GO:0008417	fucosyltransferase activity	Losses
PXYLO	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
PXYLO	GO:0005121	Toll binding	Losses
PXYLO	GO:0015924	mannosyl-oligosaccharide mannosidase activity	Losses
PXYLO	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
PXYLO	GO:0022843	voltage-gated cation channel activity	Losses
PXYLO	GO:0019903	protein phosphatase binding	Losses
PXYLO	GO:0030234	enzyme regulator activity	Losses
PXYLO	GO:0003729	mRNA binding	Losses
PXYLO	GO:0097159	organic cyclic compound binding	Losses
PXYLO	GO:0003924	GTPase activity	Losses
PXYLO	GO:1901363	heterocyclic compound binding	Losses
PXYLO	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
PXYLO	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
PXYLO	GO:0003735	structural constituent of ribosome	Extinctions
PXYLO	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
PXYLO	GO:0008301	DNA binding, bending	Extinctions
PXYLO	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
PXYLO	GO:0019843	rRNA binding	Extinctions
PXYLO	GO:0005484	SNAP receptor activity	Extinctions
PXYLO	GO:0003676	nucleic acid binding	Extinctions
PXYLO	GO:0004526	ribonuclease P activity	Extinctions
PXYLO	GO:0005515	protein binding	Extinctions
PXYLO	GO:0005198	structural molecule activity	Extinctions
PXYLO	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Extinctions
PXYLO	GO:0140110	transcription regulator activity	Extinctions
PXYLO	GO:0003723	RNA binding	Extinctions
PXYLO	GO:0017040	ceramidase activity	Extinctions
PXYLO	GO:0046922	peptide-O-fucosyltransferase activity	Extinctions
PXYLO	GO:0004502	kynurenine 3-monooxygenase activity	Extinctions
PXYLO	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	Extinctions
PXYLO	GO:0043565	sequence-specific DNA binding	Extinctions
PXYLO	GO:0004659	prenyltransferase activity	Extinctions
PXYLO	GO:0003677	DNA binding	Extinctions
PXYLO	GO:0140101	catalytic activity, acting on a tRNA	Extinctions
PXYLO	GO:0003746	translation elongation factor activity	Extinctions
PXYLO	GO:0008134	transcription factor binding	Extinctions
PXYLO	GO:0003700	DNA binding transcription factor activity	Extinctions
PXYLO	GO:0019903	protein phosphatase binding	Extinctions
PXYLO	GO:0008094	DNA-dependent ATPase activity	Extinctions
PXYLO	GO:0008417	fucosyltransferase activity	Extinctions
PXYLO	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
PXYLO	GO:0005121	Toll binding	Extinctions
PXYLO	GO:0015924	mannosyl-oligosaccharide mannosidase activity	Extinctions
PXYLO	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
PXYLO	GO:0004311	farnesyltranstransferase activity	Extinctions
PXYLO	GO:0005160	transforming growth factor beta receptor binding	Extinctions
PXYLO	GO:0004161	dimethylallyltranstransferase activity	Extinctions
PXYLO	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Extinctions
PXYLO	GO:0004738	pyruvate dehydrogenase activity	Extinctions
PXYLO	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Extinctions
PXYLO	GO:0000213	tRNA-intron endonuclease activity	Extinctions
PXYLO	GO:0009022	tRNA nucleotidyltransferase activity	Extinctions
PXYLO	GO:0019902	phosphatase binding	Extinctions
PXYLO	GO:0000149	SNARE binding	Extinctions
PXYLO	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
PXYLO	GO:0008135	translation factor activity, RNA binding	Extinctions
PXYLO	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	Extinctions
PXYLO	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Extinctions
PXYLO	GO:0004568	chitinase activity	Extinctions
PTEPI	GO:0003964	RNA-directed DNA polymerase activity	Gains
PTEPI	GO:0038023	signaling receptor activity	Gains
PTEPI	GO:0034061	DNA polymerase activity	Gains
PTEPI	GO:0099600	transmembrane receptor activity	Gains
PTEPI	GO:0060089	molecular transducer activity	Gains
PTEPI	GO:0004888	transmembrane signaling receptor activity	Gains
PTEPI	GO:0004872	receptor activity	Gains
PTEPI	GO:0004871	signal transducer activity	Gains
PTEPI	GO:0003676	nucleic acid binding	Gains
PTEPI	GO:0140097	catalytic activity, acting on DNA	Gains
PTEPI	GO:0004930	G-protein coupled receptor activity	Gains
PTEPI	GO:0016779	nucleotidyltransferase activity	Gains
PTEPI	GO:0004518	nuclease activity	Gains
PTEPI	GO:0015079	potassium ion transmembrane transporter activity	Gains
PTEPI	GO:0022836	gated channel activity	Gains
PTEPI	GO:0005216	ion channel activity	Gains
PTEPI	GO:0022838	substrate-specific channel activity	Gains
PTEPI	GO:0015267	channel activity	Gains
PTEPI	GO:0022803	passive transmembrane transporter activity	Gains
PTEPI	GO:0004519	endonuclease activity	Gains
PTEPI	GO:0008528	G-protein coupled peptide receptor activity	Gains
PTEPI	GO:0004190	aspartic-type endopeptidase activity	Gains
PTEPI	GO:0070001	aspartic-type peptidase activity	Gains
PTEPI	GO:0005249	voltage-gated potassium channel activity	Gains
PTEPI	GO:0005261	cation channel activity	Gains
PTEPI	GO:0001653	peptide receptor activity	Gains
PTEPI	GO:0008188	neuropeptide receptor activity	Gains
PTEPI	GO:0005267	potassium channel activity	Gains
PTEPI	GO:0042302	structural constituent of cuticle	Gains
PTEPI	GO:0003700	DNA binding transcription factor activity	Gains
PTEPI	GO:0008146	sulfotransferase activity	Gains
PTEPI	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
PTEPI	GO:0005452	inorganic anion exchanger activity	Gains
PTEPI	GO:0004497	monooxygenase activity	Gains
PTEPI	GO:0003677	DNA binding	Gains
PTEPI	GO:0043565	sequence-specific DNA binding	Gains
PTEPI	GO:0005549	odorant binding	Gains
PTEPI	GO:1901363	heterocyclic compound binding	Gains
PTEPI	GO:0097159	organic cyclic compound binding	Gains
PTEPI	GO:0022843	voltage-gated cation channel activity	Gains
PTEPI	GO:0005244	voltage-gated ion channel activity	Gains
PTEPI	GO:0022832	voltage-gated channel activity	Gains
PTEPI	GO:0008270	zinc ion binding	Gains
PTEPI	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
PTEPI	GO:0046914	transition metal ion binding	Gains
PTEPI	GO:0046906	tetrapyrrole binding	Gains
PTEPI	GO:0005230	extracellular ligand-gated ion channel activity	Gains
PTEPI	GO:0004745	retinol dehydrogenase activity	Gains
PTEPI	GO:0045289	luciferin monooxygenase activity	Gains
PTEPI	GO:0099516	ion antiporter activity	Gains
PTEPI	GO:0020037	heme binding	Gains
PTEPI	GO:0042562	hormone binding	Gains
PTEPI	GO:0005214	structural constituent of chitin-based cuticle	Gains
PTEPI	GO:0015297	antiporter activity	Gains
PTEPI	GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
PTEPI	GO:0022824	transmitter-gated ion channel activity	Gains
PTEPI	GO:0022835	transmitter-gated channel activity	Gains
PTEPI	GO:0004970	ionotropic glutamate receptor activity	Gains
PTEPI	GO:0015276	ligand-gated ion channel activity	Gains
PTEPI	GO:0022834	ligand-gated channel activity	Gains
PTEPI	GO:0015075	ion transmembrane transporter activity	Gains
PTEPI	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
PTEPI	GO:0022891	substrate-specific transmembrane transporter activity	Gains
PTEPI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
PTEPI	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
PTEPI	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
PTEPI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
PTEPI	GO:0022892	substrate-specific transporter activity	Gains
PTEPI	GO:0022857	transmembrane transporter activity	Gains
PTEPI	GO:0005215	transporter activity	Gains
PTEPI	GO:0050254	rhodopsin kinase activity	Gains
PTEPI	GO:0140110	transcription regulator activity	Gains
PTEPI	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
PTEPI	GO:0008241	peptidyl-dipeptidase activity	Gains
PTEPI	GO:0070405	ammonium ion binding	Gains
PTEPI	GO:0008527	taste receptor activity	Gains
PTEPI	GO:0005534	galactose binding	Gains
PTEPI	GO:0003987	acetate-CoA ligase activity	Gains
PTEPI	GO:0034481	chondroitin sulfotransferase activity	Gains
PTEPI	GO:0022821	potassium ion antiporter activity	Gains
PTEPI	GO:0031208	POZ domain binding	Gains
PTEPI	GO:0015103	inorganic anion transmembrane transporter activity	Gains
PTEPI	GO:0015368	calcium:cation antiporter activity	Gains
PTEPI	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
PTEPI	GO:0004691	cAMP-dependent protein kinase activity	Gains
PTEPI	GO:0015645	fatty acid ligase activity	Gains
PTEPI	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
PTEPI	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
PTEPI	GO:0004601	peroxidase activity	Gains
PTEPI	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
PTEPI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
PTEPI	GO:0046873	metal ion transmembrane transporter activity	Gains
PTEPI	GO:0016209	antioxidant activity	Gains
PTEPI	GO:0015491	cation:cation antiporter activity	Gains
PTEPI	GO:0016405	CoA-ligase activity	Gains
PTEPI	GO:0008509	anion transmembrane transporter activity	Gains
PTEPI	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
PTEPI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
PTEPI	GO:0008066	glutamate receptor activity	Gains
PTEPI	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
PTEPI	GO:0000975	regulatory region DNA binding	Gains
PTEPI	GO:0001067	regulatory region nucleic acid binding	Gains
PTEPI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
PTEPI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
PTEPI	GO:0046974	histone methyltransferase activity (H3-K9 specific)	Losses
PTEPI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
PTEPI	GO:0004521	endoribonuclease activity	Losses
PTEPI	GO:0098772	molecular function regulator	Losses
PTEPI	GO:0004133	glycogen debranching enzyme activity	Losses
PTEPI	GO:0004134	4-alpha-glucanotransferase activity	Losses
PTEPI	GO:0004135	amylo-alpha-1,6-glucosidase activity	Losses
PTEPI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
PTEPI	GO:0005096	GTPase activator activity	Losses
PTEPI	GO:0060589	nucleoside-triphosphatase regulator activity	Losses
PTEPI	GO:0008170	N-methyltransferase activity	Losses
PTEPI	GO:0046872	metal ion binding	Losses
PTEPI	GO:0004519	endonuclease activity	Losses
PTEPI	GO:0008047	enzyme activator activity	Losses
PTEPI	GO:0004430	1-phosphatidylinositol 4-kinase activity	Losses
PTEPI	GO:0003682	chromatin binding	Losses
PTEPI	GO:0043169	cation binding	Losses
PTEPI	GO:0005179	hormone activity	Losses
PTEPI	GO:0030695	GTPase regulator activity	Losses
PTEPI	GO:0016757	transferase activity, transferring glycosyl groups	Losses
PTEPI	GO:0016278	lysine N-methyltransferase activity	Losses
PTEPI	GO:0016279	protein-lysine N-methyltransferase activity	Losses
PTEPI	GO:0018024	histone-lysine N-methyltransferase activity	Losses
PTEPI	GO:0016740	transferase activity	Losses
PTEPI	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
PTEPI	GO:0004674	protein serine/threonine kinase activity	Losses
PTEPI	GO:0140096	catalytic activity, acting on a protein	Losses
PTEPI	GO:0017016	Ras GTPase binding	Losses
PTEPI	GO:0004540	ribonuclease activity	Losses
PTEPI	GO:0031267	small GTPase binding	Losses
PTEPI	GO:0034061	DNA polymerase activity	Losses
PTEPI	GO:0030234	enzyme regulator activity	Losses
PTEPI	GO:0043492	ATPase activity, coupled to movement of substances	Losses
PTEPI	GO:0043167	ion binding	Losses
PTEPI	GO:0008276	protein methyltransferase activity	Losses
PTEPI	GO:0004672	protein kinase activity	Losses
PTEPI	GO:0016779	nucleotidyltransferase activity	Losses
PTEPI	GO:0008194	UDP-glycosyltransferase activity	Losses
PTEPI	GO:0048365	Rac GTPase binding	Losses
PTEPI	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
PTEPI	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Losses
PTEPI	GO:0008307	structural constituent of muscle	Losses
PTEPI	GO:0008017	microtubule binding	Losses
PTEPI	GO:0004803	transposase activity	Losses
PTEPI	GO:0005524	ATP binding	Losses
PTEPI	GO:0032559	adenyl ribonucleotide binding	Losses
PTEPI	GO:0042054	histone methyltransferase activity	Losses
PTEPI	GO:0101005	ubiquitinyl hydrolase activity	Losses
PTEPI	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
PTEPI	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
PTEPI	GO:0052742	phosphatidylinositol kinase activity	Losses
PTEPI	GO:0045296	cadherin binding	Losses
PTEPI	GO:0008013	beta-catenin binding	Losses
PTEPI	GO:0004012	phospholipid-translocating ATPase activity	Losses
PTEPI	GO:0008395	steroid hydroxylase activity	Losses
PTEPI	GO:0030554	adenyl nucleotide binding	Losses
PTEPI	GO:0048018	receptor ligand activity	Losses
PTEPI	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
PTEPI	GO:0015631	tubulin binding	Losses
PTEPI	GO:0016301	kinase activity	Losses
PTEPI	GO:0015171	amino acid transmembrane transporter activity	Losses
PTEPI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
PTEPI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
PTEPI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
PTEPI	GO:0004521	endoribonuclease activity	Extinctions
PTEPI	GO:0004519	endonuclease activity	Extinctions
PTEPI	GO:0005179	hormone activity	Extinctions
PTEPI	GO:0015923	mannosidase activity	Extinctions
PTEPI	GO:0004540	ribonuclease activity	Extinctions
PTEPI	GO:0048018	receptor ligand activity	Extinctions
PTEPI	GO:0030545	receptor regulator activity	Extinctions
PTEPI	GO:0003777	microtubule motor activity	Extinctions
PTEPI	GO:0016085	myoinhibitory hormone activity	Extinctions
PTEPI	GO:0050700	CARD domain binding	Extinctions
PTEPI	GO:0018271	biotin-protein ligase activity	Extinctions
PTEPI	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
PTEPI	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
PTEPI	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Extinctions
PTEPI	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Extinctions
PTEPI	GO:0005184	neuropeptide hormone activity	Extinctions
PTEPI	GO:0016757	transferase activity, transferring glycosyl groups	Extinctions
PTEPI	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
PTEPI	GO:0008194	UDP-glycosyltransferase activity	Extinctions
PTEPI	GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
PTEPI	GO:0004133	glycogen debranching enzyme activity	Extinctions
PTEPI	GO:0004134	4-alpha-glucanotransferase activity	Extinctions
PTEPI	GO:0004135	amylo-alpha-1,6-glucosidase activity	Extinctions
PTEPI	GO:0097322	7SK snRNA binding	Extinctions
PTEPI	GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
PTEPI	GO:0004511	tyrosine 3-monooxygenase activity	Extinctions
PTEPI	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Extinctions
PTEPI	GO:0004644	phosphoribosylglycinamide formyltransferase activity	Extinctions
PTEPI	GO:0032093	SAM domain binding	Extinctions
PTEPI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
PTEPI	GO:0004518	nuclease activity	Extinctions
OFAS2	GO:0005549	odorant binding	Gains
OFAS2	GO:0004984	olfactory receptor activity	Gains
OFAS2	GO:0008527	taste receptor activity	Gains
OFAS2	GO:0061134	peptidase regulator activity	Gains
OFAS2	GO:0030414	peptidase inhibitor activity	Gains
OFAS2	GO:0004857	enzyme inhibitor activity	Gains
OFAS2	GO:0098772	molecular function regulator	Gains
OFAS2	GO:0004888	transmembrane signaling receptor activity	Gains
OFAS2	GO:0099600	transmembrane receptor activity	Gains
OFAS2	GO:0004866	endopeptidase inhibitor activity	Gains
OFAS2	GO:0051020	GTPase binding	Gains
OFAS2	GO:0004535	poly(A)-specific ribonuclease activity	Gains
OFAS2	GO:0000217	DNA secondary structure binding	Gains
OFAS2	GO:0003964	RNA-directed DNA polymerase activity	Gains
OFAS2	GO:0015631	tubulin binding	Gains
OFAS2	GO:0061135	endopeptidase regulator activity	Gains
OFAS2	GO:0017137	Rab GTPase binding	Gains
OFAS2	GO:0003774	motor activity	Gains
OFAS2	GO:0030234	enzyme regulator activity	Gains
OFAS2	GO:0008017	microtubule binding	Gains
OFAS2	GO:0031267	small GTPase binding	Gains
OFAS2	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
OFAS2	GO:0005158	insulin receptor binding	Gains
OFAS2	GO:0030898	actin-dependent ATPase activity	Gains
OFAS2	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Gains
OFAS2	GO:0000400	four-way junction DNA binding	Gains
OFAS2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	Gains
OFAS2	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Gains
OFAS2	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Gains
OFAS2	GO:0033041	sweet taste receptor activity	Gains
OFAS2	GO:0016407	acetyltransferase activity	Gains
OFAS2	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
OFAS2	GO:0017016	Ras GTPase binding	Gains
OFAS2	GO:0004930	G-protein coupled receptor activity	Gains
OFAS2	GO:0008080	N-acetyltransferase activity	Gains
OFAS2	GO:0038023	signaling receptor activity	Gains
OFAS2	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
OFAS2	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Gains
OFAS2	GO:0004532	exoribonuclease activity	Gains
OFAS2	GO:0016410	N-acyltransferase activity	Gains
OFAS2	GO:0004402	histone acetyltransferase activity	Gains
OFAS2	GO:0008408	3'-5' exonuclease activity	Gains
OFAS2	GO:0000175	3'-5'-exoribonuclease activity	Gains
OFAS2	GO:0030247	polysaccharide binding	Gains
OFAS2	GO:0001871	pattern binding	Gains
OFAS2	GO:0016504	peptidase activator activity	Gains
OFAS2	GO:0061733	peptide-lysine-N-acetyltransferase activity	Gains
OFAS2	GO:0005516	calmodulin binding	Gains
OFAS2	GO:0004518	nuclease activity	Gains
OFAS2	GO:0019840	isoprenoid binding	Gains
OFAS2	GO:0005086	ARF guanyl-nucleotide exchange factor activity	Gains
OFAS2	GO:0005201	extracellular matrix structural constituent	Gains
OFAS2	GO:0003700	DNA binding transcription factor activity	Losses
OFAS2	GO:0070001	aspartic-type peptidase activity	Losses
OFAS2	GO:0004190	aspartic-type endopeptidase activity	Losses
OFAS2	GO:0140110	transcription regulator activity	Losses
OFAS2	GO:0003964	RNA-directed DNA polymerase activity	Losses
OFAS2	GO:0034061	DNA polymerase activity	Losses
OFAS2	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Losses
OFAS2	GO:0140097	catalytic activity, acting on DNA	Losses
OFAS2	GO:0003796	lysozyme activity	Losses
OFAS2	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
OFAS2	GO:0001882	nucleoside binding	Losses
OFAS2	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
OFAS2	GO:0016406	carnitine O-acyltransferase activity	Losses
OFAS2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Losses
OFAS2	GO:0004792	thiosulfate sulfurtransferase activity	Losses
OFAS2	GO:0016491	oxidoreductase activity	Losses
OFAS2	GO:0016783	sulfurtransferase activity	Losses
OFAS2	GO:0032550	purine ribonucleoside binding	Losses
OFAS2	GO:0005525	GTP binding	Losses
OFAS2	GO:0001883	purine nucleoside binding	Losses
OFAS2	GO:0043565	sequence-specific DNA binding	Losses
OFAS2	GO:0032561	guanyl ribonucleotide binding	Losses
OFAS2	GO:0032549	ribonucleoside binding	Losses
OFAS2	GO:0046873	metal ion transmembrane transporter activity	Losses
OFAS2	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
OFAS2	GO:0019001	guanyl nucleotide binding	Losses
OFAS2	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
OFAS2	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
OFAS2	GO:0015408	ferric-transporting ATPase activity	Losses
OFAS2	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Losses
OFAS2	GO:0048038	quinone binding	Losses
OFAS2	GO:0015091	ferric iron transmembrane transporter activity	Losses
OFAS2	GO:0000104	succinate dehydrogenase activity	Losses
OFAS2	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Losses
OFAS2	GO:0003677	DNA binding	Losses
OFAS2	GO:1990837	sequence-specific double-stranded DNA binding	Losses
OFAS2	GO:0004180	carboxypeptidase activity	Losses
OFAS2	GO:0008238	exopeptidase activity	Losses
OFAS2	GO:0044212	transcription regulatory region DNA binding	Losses
OFAS2	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
OFAS2	GO:0061783	peptidoglycan muralytic activity	Losses
OFAS2	GO:0001067	regulatory region nucleic acid binding	Losses
OFAS2	GO:0000975	regulatory region DNA binding	Losses
OFAS2	GO:0016787	hydrolase activity	Losses
OFAS2	GO:0004871	signal transducer activity	Losses
OFAS2	GO:0003690	double-stranded DNA binding	Losses
OFAS2	GO:0008239	dipeptidyl-peptidase activity	Losses
OFAS2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Losses
OFAS2	GO:0003954	NADH dehydrogenase activity	Losses
OFAS2	GO:0015075	ion transmembrane transporter activity	Losses
OFAS2	GO:0003924	GTPase activity	Losses
OFAS2	GO:0008237	metallopeptidase activity	Losses
OFAS2	GO:0008233	peptidase activity	Losses
OFAS2	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
OFAS2	GO:0008081	phosphoric diester hydrolase activity	Losses
OFAS2	GO:0008235	metalloexopeptidase activity	Losses
OFAS2	GO:0015081	sodium ion transmembrane transporter activity	Losses
OFAS2	GO:0005381	iron ion transmembrane transporter activity	Losses
OFAS2	GO:0008519	ammonium transmembrane transporter activity	Losses
OFAS2	GO:1990939	ATP-dependent microtubule motor activity	Losses
OFAS2	GO:0022857	transmembrane transporter activity	Losses
OFAS2	GO:0004177	aminopeptidase activity	Losses
OFAS2	GO:0003824	catalytic activity	Losses
OFAS2	GO:0060089	molecular transducer activity	Losses
OFAS2	GO:0004175	endopeptidase activity	Losses
OFAS2	GO:0008301	DNA binding, bending	Losses
OFAS2	GO:0003714	transcription corepressor activity	Losses
OFAS2	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
OFAS2	GO:0004697	protein kinase C activity	Losses
OFAS2	GO:0003990	acetylcholinesterase activity	Losses
OFAS2	GO:0022890	inorganic cation transmembrane transporter activity	Losses
OFAS2	GO:0004872	receptor activity	Losses
OFAS2	GO:0022891	substrate-specific transmembrane transporter activity	Losses
OFAS2	GO:0008324	cation transmembrane transporter activity	Losses
OFAS2	GO:0070491	repressing transcription factor binding	Losses
OFAS2	GO:0034584	piRNA binding	Losses
OFAS2	GO:0005329	dopamine transmembrane transporter activity	Losses
OFAS2	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
OFAS2	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Losses
OFAS2	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
OFAS2	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
OFAS2	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
OFAS2	GO:0008473	ornithine cyclodeaminase activity	Losses
OFAS2	GO:0008445	D-aspartate oxidase activity	Losses
OFAS2	GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	Losses
OFAS2	GO:0005415	nucleoside:sodium symporter activity	Losses
OFAS2	GO:0019811	cocaine binding	Losses
OFAS2	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
OFAS2	GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Losses
OFAS2	GO:0071906	CRD domain binding	Losses
OFAS2	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Losses
OFAS2	GO:0008251	tRNA-specific adenosine deaminase activity	Losses
OFAS2	GO:0015220	choline transmembrane transporter activity	Losses
OFAS2	GO:0015222	serotonin transmembrane transporter activity	Losses
OFAS2	GO:0004392	heme oxygenase (decyclizing) activity	Losses
OFAS2	GO:0031071	cysteine desulfurase activity	Losses
OFAS2	GO:0003884	D-amino-acid oxidase activity	Losses
OFAS2	GO:0031005	filamin binding	Losses
OFAS2	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Losses
OFAS2	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
OFAS2	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
OFAS2	GO:0001106	RNA polymerase II transcription corepressor activity	Losses
OFAS2	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Losses
OFAS2	GO:0051538	3 iron, 4 sulfur cluster binding	Losses
OFAS2	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
OFAS2	GO:0035755	cardiolipin hydrolase activity	Losses
OFAS2	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	Losses
OFAS2	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Losses
OFAS2	GO:0004807	triose-phosphate isomerase activity	Losses
OFAS2	GO:0004566	beta-glucuronidase activity	Losses
OFAS2	GO:0004557	alpha-galactosidase activity	Losses
OFAS2	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
OFAS2	GO:0071837	HMG box domain binding	Losses
OFAS2	GO:0004510	tryptophan 5-monooxygenase activity	Losses
OFAS2	GO:0052870	tocopherol omega-hydroxylase activity	Losses
OFAS2	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
OFAS2	GO:0005026	transforming growth factor beta receptor activity, type II	Losses
OFAS2	GO:0036132	13-prostaglandin reductase activity	Losses
OFAS2	GO:0017172	cysteine dioxygenase activity	Losses
OFAS2	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Losses
OFAS2	GO:0004505	phenylalanine 4-monooxygenase activity	Losses
OFAS2	GO:0015922	aspartate oxidase activity	Losses
OFAS2	GO:0036263	L-DOPA monooxygenase activity	Losses
OFAS2	GO:0036264	dopamine monooxygenase activity	Losses
OFAS2	GO:0042943	D-amino acid transmembrane transporter activity	Losses
OFAS2	GO:0052692	raffinose alpha-galactosidase activity	Losses
OFAS2	GO:0000700	mismatch base pair DNA N-glycosylase activity	Losses
OFAS2	GO:0004092	carnitine O-acetyltransferase activity	Losses
OFAS2	GO:0004097	catechol oxidase activity	Losses
OFAS2	GO:0003700	DNA binding transcription factor activity	Extinctions
OFAS2	GO:0140110	transcription regulator activity	Extinctions
OFAS2	GO:0004792	thiosulfate sulfurtransferase activity	Extinctions
OFAS2	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
OFAS2	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
OFAS2	GO:0044212	transcription regulatory region DNA binding	Extinctions
OFAS2	GO:0001067	regulatory region nucleic acid binding	Extinctions
OFAS2	GO:0000975	regulatory region DNA binding	Extinctions
OFAS2	GO:0003690	double-stranded DNA binding	Extinctions
OFAS2	GO:0003796	lysozyme activity	Extinctions
OFAS2	GO:0016783	sulfurtransferase activity	Extinctions
OFAS2	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
OFAS2	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
OFAS2	GO:0008473	ornithine cyclodeaminase activity	Extinctions
OFAS2	GO:0008445	D-aspartate oxidase activity	Extinctions
OFAS2	GO:0004392	heme oxygenase (decyclizing) activity	Extinctions
OFAS2	GO:0003884	D-amino-acid oxidase activity	Extinctions
OFAS2	GO:0035755	cardiolipin hydrolase activity	Extinctions
OFAS2	GO:0017172	cysteine dioxygenase activity	Extinctions
OFAS2	GO:0015922	aspartate oxidase activity	Extinctions
OFAS2	GO:0004092	carnitine O-acetyltransferase activity	Extinctions
OFAS2	GO:0034061	DNA polymerase activity	Extinctions
OFAS2	GO:0061783	peptidoglycan muralytic activity	Extinctions
OFAS2	GO:0016790	thiolester hydrolase activity	Extinctions
OFAS2	GO:0043565	sequence-specific DNA binding	Extinctions
OFAS2	GO:0140097	catalytic activity, acting on DNA	Extinctions
OFAS2	GO:0004180	carboxypeptidase activity	Extinctions
ACEPH	GO:0004984	olfactory receptor activity	Gains
ACEPH	GO:0005549	odorant binding	Gains
ACEPH	GO:0004930	G-protein coupled receptor activity	Gains
ACEPH	GO:0004888	transmembrane signaling receptor activity	Gains
ACEPH	GO:0099600	transmembrane receptor activity	Gains
ACEPH	GO:0038023	signaling receptor activity	Gains
ACEPH	GO:0004871	signal transducer activity	Gains
ACEPH	GO:0004872	receptor activity	Gains
ACEPH	GO:0060089	molecular transducer activity	Gains
ACEPH	GO:0003964	RNA-directed DNA polymerase activity	Gains
ACEPH	GO:0034061	DNA polymerase activity	Gains
ACEPH	GO:0004500	dopamine beta-monooxygenase activity	Gains
ACEPH	GO:0022803	passive transmembrane transporter activity	Gains
ACEPH	GO:0015267	channel activity	Gains
ACEPH	GO:0010181	FMN binding	Gains
ACEPH	GO:0005216	ion channel activity	Gains
ACEPH	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
ACEPH	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
ACEPH	GO:0005245	voltage-gated calcium channel activity	Gains
ACEPH	GO:0022838	substrate-specific channel activity	Gains
ACEPH	GO:0008146	sulfotransferase activity	Gains
ACEPH	GO:0015075	ion transmembrane transporter activity	Gains
ACEPH	GO:0008237	metallopeptidase activity	Gains
ACEPH	GO:0140097	catalytic activity, acting on DNA	Gains
ACEPH	GO:0022857	transmembrane transporter activity	Gains
ACEPH	GO:0022892	substrate-specific transporter activity	Gains
ACEPH	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Gains
ACEPH	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Gains
ACEPH	GO:0008332	low voltage-gated calcium channel activity	Gains
ACEPH	GO:0004014	adenosylmethionine decarboxylase activity	Gains
ACEPH	GO:0008449	N-acetylglucosamine-6-sulfatase activity	Gains
ACEPH	GO:0008890	glycine C-acetyltransferase activity	Gains
ACEPH	GO:0051371	muscle alpha-actinin binding	Gains
ACEPH	GO:0098518	polynucleotide phosphatase activity	Gains
ACEPH	GO:0046914	transition metal ion binding	Gains
ACEPH	GO:0003676	nucleic acid binding	Gains
ACEPH	GO:0008270	zinc ion binding	Gains
ACEPH	GO:0022891	substrate-specific transmembrane transporter activity	Gains
ACEPH	GO:0022832	voltage-gated channel activity	Gains
ACEPH	GO:0005244	voltage-gated ion channel activity	Gains
ACEPH	GO:0016615	malate dehydrogenase activity	Gains
ACEPH	GO:0008239	dipeptidyl-peptidase activity	Gains
ACEPH	GO:0022890	inorganic cation transmembrane transporter activity	Gains
ACEPH	GO:0004222	metalloendopeptidase activity	Gains
ACEPH	GO:0004518	nuclease activity	Gains
ACEPH	GO:0005215	transporter activity	Gains
ACEPH	GO:0005262	calcium channel activity	Gains
ACEPH	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
ACEPH	GO:0043394	proteoglycan binding	Gains
ACEPH	GO:0043395	heparan sulfate proteoglycan binding	Gains
ACEPH	GO:0042805	actinin binding	Gains
ACEPH	GO:0004948	calcitonin receptor activity	Gains
ACEPH	GO:0016453	C-acetyltransferase activity	Gains
ACEPH	GO:0097642	calcitonin family receptor activity	Gains
ACEPH	GO:0004470	malic enzyme activity	Gains
ACEPH	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
ACEPH	GO:0051393	alpha-actinin binding	Gains
ACEPH	GO:0004713	protein tyrosine kinase activity	Gains
ACEPH	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	Gains
ACEPH	GO:0070491	repressing transcription factor binding	Gains
ACEPH	GO:0008227	G-protein coupled amine receptor activity	Gains
ACEPH	GO:0008324	cation transmembrane transporter activity	Gains
ACEPH	GO:0046872	metal ion binding	Gains
ACEPH	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
ACEPH	GO:0022836	gated channel activity	Gains
ACEPH	GO:0005261	cation channel activity	Gains
ACEPH	GO:0043169	cation binding	Gains
ACEPH	GO:0004190	aspartic-type endopeptidase activity	Losses
ACEPH	GO:0070001	aspartic-type peptidase activity	Losses
ACEPH	GO:0034061	DNA polymerase activity	Losses
ACEPH	GO:0140097	catalytic activity, acting on DNA	Losses
ACEPH	GO:0008233	peptidase activity	Losses
ACEPH	GO:0008270	zinc ion binding	Losses
ACEPH	GO:0004175	endopeptidase activity	Losses
ACEPH	GO:0046914	transition metal ion binding	Losses
ACEPH	GO:0003964	RNA-directed DNA polymerase activity	Losses
ACEPH	GO:0016779	nucleotidyltransferase activity	Losses
ACEPH	GO:0009055	electron transfer activity	Losses
ACEPH	GO:0003677	DNA binding	Losses
ACEPH	GO:0003676	nucleic acid binding	Losses
ACEPH	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
ACEPH	GO:0071855	neuropeptide receptor binding	Losses
ACEPH	GO:0050591	quinine 3-monooxygenase activity	Losses
ACEPH	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
ACEPH	GO:0004803	transposase activity	Losses
ACEPH	GO:0004518	nuclease activity	Losses
ACEPH	GO:0005184	neuropeptide hormone activity	Losses
ACEPH	GO:0046872	metal ion binding	Losses
ACEPH	GO:0004806	triglyceride lipase activity	Losses
ACEPH	GO:0005179	hormone activity	Losses
ACEPH	GO:0043169	cation binding	Losses
ACEPH	GO:0070330	aromatase activity	Losses
ACEPH	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
ACEPH	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
ACEPH	GO:0030246	carbohydrate binding	Losses
ACEPH	GO:0030247	polysaccharide binding	Losses
ACEPH	GO:0001871	pattern binding	Losses
ACEPH	GO:0048018	receptor ligand activity	Losses
ACEPH	GO:0004734	pyrimidodiazepine synthase activity	Losses
ACEPH	GO:0030267	glyoxylate reductase (NADP) activity	Losses
ACEPH	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
ACEPH	GO:0097493	structural molecule activity conferring elasticity	Losses
ACEPH	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Losses
ACEPH	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Losses
ACEPH	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
ACEPH	GO:0050111	mycocerosate synthase activity	Losses
ACEPH	GO:0071861	tachykinin receptor binding	Losses
ACEPH	GO:0018445	prothoracicotrophic hormone activity	Losses
ACEPH	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
ACEPH	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Losses
ACEPH	GO:0015277	kainate selective glutamate receptor activity	Losses
ACEPH	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
ACEPH	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
ACEPH	GO:0005122	torso binding	Losses
ACEPH	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
ACEPH	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
ACEPH	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
ACEPH	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
ACEPH	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
ACEPH	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
ACEPH	GO:0042947	glucoside transmembrane transporter activity	Losses
ACEPH	GO:0015574	trehalose transmembrane transporter activity	Losses
ACEPH	GO:0047964	glyoxylate reductase activity	Losses
ACEPH	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
ACEPH	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
ACEPH	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
ACEPH	GO:0004796	thromboxane-A synthase activity	Losses
ACEPH	GO:0004000	adenosine deaminase activity	Losses
ACEPH	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
ACEPH	GO:0004497	monooxygenase activity	Losses
ACEPH	GO:0030545	receptor regulator activity	Losses
ACEPH	GO:0005230	extracellular ligand-gated ion channel activity	Losses
ACEPH	GO:0042302	structural constituent of cuticle	Losses
ACEPH	GO:0004711	ribosomal protein S6 kinase activity	Losses
ACEPH	GO:0015037	peptide disulfide oxidoreductase activity	Losses
ACEPH	GO:0015038	glutathione disulfide oxidoreductase activity	Losses
ACEPH	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
ACEPH	GO:0004503	monophenol monooxygenase activity	Losses
ACEPH	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
ACEPH	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
ACEPH	GO:0015154	disaccharide transmembrane transporter activity	Losses
ACEPH	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
ACEPH	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
ACEPH	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
ACEPH	GO:0004337	geranyltranstransferase activity	Losses
ACEPH	GO:0016420	malonyltransferase activity	Losses
ACEPH	GO:0008200	ion channel inhibitor activity	Losses
ACEPH	GO:0016419	S-malonyltransferase activity	Losses
ACEPH	GO:0045735	nutrient reservoir activity	Losses
ACEPH	GO:0005212	structural constituent of eye lens	Losses
ACEPH	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
ACEPH	GO:0018685	alkane 1-monooxygenase activity	Losses
ACEPH	GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	Losses
ACEPH	GO:0016248	channel inhibitor activity	Losses
ACEPH	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
ACEPH	GO:0004190	aspartic-type endopeptidase activity	Extinctions
ACEPH	GO:0070001	aspartic-type peptidase activity	Extinctions
ACEPH	GO:0008270	zinc ion binding	Extinctions
ACEPH	GO:0046914	transition metal ion binding	Extinctions
ACEPH	GO:0004175	endopeptidase activity	Extinctions
ACEPH	GO:0034061	DNA polymerase activity	Extinctions
ACEPH	GO:0140097	catalytic activity, acting on DNA	Extinctions
ACEPH	GO:0016779	nucleotidyltransferase activity	Extinctions
ACEPH	GO:0071855	neuropeptide receptor binding	Extinctions
ACEPH	GO:0005184	neuropeptide hormone activity	Extinctions
ACEPH	GO:0009055	electron transfer activity	Extinctions
ACEPH	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
ACEPH	GO:0005179	hormone activity	Extinctions
ACEPH	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
ACEPH	GO:0008233	peptidase activity	Extinctions
ACEPH	GO:0048018	receptor ligand activity	Extinctions
ACEPH	GO:0030545	receptor regulator activity	Extinctions
ACEPH	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
ACEPH	GO:0071861	tachykinin receptor binding	Extinctions
ACEPH	GO:0018445	prothoracicotrophic hormone activity	Extinctions
ACEPH	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
ACEPH	GO:0005122	torso binding	Extinctions
ACEPH	GO:0001664	G-protein coupled receptor binding	Extinctions
ACEPH	GO:0008200	ion channel inhibitor activity	Extinctions
ACEPH	GO:0016248	channel inhibitor activity	Extinctions
ACEPH	GO:0003677	DNA binding	Extinctions
ACEPH	GO:0003676	nucleic acid binding	Extinctions
ACEPH	GO:0046872	metal ion binding	Extinctions
ACEPH	GO:0043169	cation binding	Extinctions
ACEPH	GO:0050591	quinine 3-monooxygenase activity	Extinctions
ACEPH	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
ACEPH	GO:0004222	metalloendopeptidase activity	Extinctions
APLAN	GO:0003964	RNA-directed DNA polymerase activity	Gains
APLAN	GO:0140097	catalytic activity, acting on DNA	Gains
APLAN	GO:0034061	DNA polymerase activity	Gains
APLAN	GO:0016779	nucleotidyltransferase activity	Gains
APLAN	GO:0004190	aspartic-type endopeptidase activity	Gains
APLAN	GO:0070001	aspartic-type peptidase activity	Gains
APLAN	GO:0003678	DNA helicase activity	Gains
APLAN	GO:0046914	transition metal ion binding	Gains
APLAN	GO:0004518	nuclease activity	Gains
APLAN	GO:0008270	zinc ion binding	Gains
APLAN	GO:0050662	coenzyme binding	Gains
APLAN	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
APLAN	GO:0015370	solute:sodium symporter activity	Gains
APLAN	GO:0048037	cofactor binding	Gains
APLAN	GO:0015294	solute:cation symporter activity	Gains
APLAN	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	Gains
APLAN	GO:0030151	molybdenum ion binding	Gains
APLAN	GO:0050661	NADP binding	Gains
APLAN	GO:0050660	flavin adenine dinucleotide binding	Gains
APLAN	GO:0005328	neurotransmitter:sodium symporter activity	Gains
APLAN	GO:0043546	molybdopterin cofactor binding	Gains
APLAN	GO:0008240	tripeptidyl-peptidase activity	Gains
APLAN	GO:0004517	nitric-oxide synthase activity	Gains
APLAN	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Gains
APLAN	GO:0004322	ferroxidase activity	Gains
APLAN	GO:0042171	lysophosphatidic acid acyltransferase activity	Gains
APLAN	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Gains
APLAN	GO:0008812	choline dehydrogenase activity	Gains
APLAN	GO:0016411	acylglycerol O-acyltransferase activity	Gains
APLAN	GO:0015293	symporter activity	Gains
APLAN	GO:0008061	chitin binding	Gains
APLAN	GO:0004519	endonuclease activity	Gains
APLAN	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
APLAN	GO:0005326	neurotransmitter transporter activity	Gains
APLAN	GO:0003777	microtubule motor activity	Gains
APLAN	GO:0004344	glucose dehydrogenase activity	Gains
APLAN	GO:0004386	helicase activity	Gains
APLAN	GO:0004930	G-protein coupled receptor activity	Gains
APLAN	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
APLAN	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
APLAN	GO:0043169	cation binding	Gains
APLAN	GO:0016841	ammonia-lyase activity	Gains
APLAN	GO:0097642	calcitonin family receptor activity	Gains
APLAN	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	Gains
APLAN	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Gains
APLAN	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
APLAN	GO:0004657	proline dehydrogenase activity	Gains
APLAN	GO:0004630	phospholipase D activity	Gains
APLAN	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
APLAN	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
APLAN	GO:0004948	calcitonin receptor activity	Gains
APLAN	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
APLAN	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
APLAN	GO:0005201	extracellular matrix structural constituent	Losses
APLAN	GO:0008528	G-protein coupled peptide receptor activity	Losses
APLAN	GO:0001653	peptide receptor activity	Losses
APLAN	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
APLAN	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
APLAN	GO:0004045	aminoacyl-tRNA hydrolase activity	Losses
APLAN	GO:0099600	transmembrane receptor activity	Losses
APLAN	GO:0052689	carboxylic ester hydrolase activity	Losses
APLAN	GO:0015605	organophosphate ester transmembrane transporter activity	Losses
APLAN	GO:0004983	neuropeptide Y receptor activity	Losses
APLAN	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
APLAN	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Losses
APLAN	GO:0045505	dynein intermediate chain binding	Losses
APLAN	GO:0015183	L-aspartate transmembrane transporter activity	Losses
APLAN	GO:0018685	alkane 1-monooxygenase activity	Losses
APLAN	GO:0015562	efflux transmembrane transporter activity	Losses
APLAN	GO:0015501	glutamate:sodium symporter activity	Losses
APLAN	GO:0050591	quinine 3-monooxygenase activity	Losses
APLAN	GO:0005214	structural constituent of chitin-based cuticle	Losses
APLAN	GO:0042834	peptidoglycan binding	Losses
APLAN	GO:0008188	neuropeptide receptor activity	Losses
APLAN	GO:0004568	chitinase activity	Losses
APLAN	GO:0070330	aromatase activity	Losses
APLAN	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Losses
APLAN	GO:0015604	organic phosphonate transmembrane transporter activity	Losses
APLAN	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
APLAN	GO:0004930	G-protein coupled receptor activity	Losses
APLAN	GO:0005272	sodium channel activity	Losses
APLAN	GO:0015081	sodium ion transmembrane transporter activity	Losses
APLAN	GO:0004364	glutathione transferase activity	Losses
APLAN	GO:0008190	eukaryotic initiation factor 4E binding	Losses
APLAN	GO:0005416	cation:amino acid symporter activity	Losses
APLAN	GO:0005283	sodium:amino acid symporter activity	Losses
APLAN	GO:0004064	arylesterase activity	Losses
APLAN	GO:0004040	amidase activity	Losses
APLAN	GO:0004977	melanocortin receptor activity	Losses
APLAN	GO:0004888	transmembrane signaling receptor activity	Losses
APLAN	GO:0042302	structural constituent of cuticle	Losses
APLAN	GO:0008509	anion transmembrane transporter activity	Losses
APLAN	GO:0004984	olfactory receptor activity	Losses
APLAN	GO:0015075	ion transmembrane transporter activity	Losses
APLAN	GO:0060089	molecular transducer activity	Losses
APLAN	GO:0005506	iron ion binding	Losses
APLAN	GO:0004871	signal transducer activity	Losses
APLAN	GO:0016787	hydrolase activity	Losses
APLAN	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
APLAN	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
APLAN	GO:0022891	substrate-specific transmembrane transporter activity	Losses
APLAN	GO:0061783	peptidoglycan muralytic activity	Losses
APLAN	GO:0017153	sodium:dicarboxylate symporter activity	Losses
APLAN	GO:0008527	taste receptor activity	Losses
APLAN	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Losses
APLAN	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Losses
APLAN	GO:0004872	receptor activity	Losses
APLAN	GO:0038023	signaling receptor activity	Losses
APLAN	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
APLAN	GO:0022857	transmembrane transporter activity	Losses
APLAN	GO:0004222	metalloendopeptidase activity	Losses
APLAN	GO:0005215	transporter activity	Losses
APLAN	GO:0020037	heme binding	Losses
APLAN	GO:0005313	L-glutamate transmembrane transporter activity	Losses
APLAN	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
APLAN	GO:0015172	acidic amino acid transmembrane transporter activity	Losses
APLAN	GO:0042910	xenobiotic transmembrane transporter activity	Losses
APLAN	GO:0008061	chitin binding	Losses
APLAN	GO:0046906	tetrapyrrole binding	Losses
APLAN	GO:0008237	metallopeptidase activity	Losses
APLAN	GO:0004623	phospholipase A2 activity	Losses
APLAN	GO:0030545	receptor regulator activity	Losses
APLAN	GO:0004497	monooxygenase activity	Losses
APLAN	GO:0030246	carbohydrate binding	Losses
APLAN	GO:0004045	aminoacyl-tRNA hydrolase activity	Extinctions
APLAN	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
APLAN	GO:0045505	dynein intermediate chain binding	Extinctions
APLAN	GO:0005201	extracellular matrix structural constituent	Extinctions
APLAN	GO:0008190	eukaryotic initiation factor 4E binding	Extinctions
APLAN	GO:0008527	taste receptor activity	Extinctions
APLAN	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Extinctions
APLAN	GO:0005272	sodium channel activity	Extinctions
APLAN	GO:0004222	metalloendopeptidase activity	Extinctions
APLAN	GO:0052689	carboxylic ester hydrolase activity	Extinctions
APLAN	GO:0004551	nucleotide diphosphatase activity	Extinctions
APLAN	GO:0003960	NADPH:quinone reductase activity	Extinctions
APLAN	GO:0004047	aminomethyltransferase activity	Extinctions
APLAN	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Extinctions
APLAN	GO:0004984	olfactory receptor activity	Extinctions
APLAN	GO:0015081	sodium ion transmembrane transporter activity	Extinctions
APLAN	GO:0030246	carbohydrate binding	Extinctions
APLAN	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Extinctions
APLAN	GO:0004835	tubulin-tyrosine ligase activity	Extinctions
APLAN	GO:0015604	organic phosphonate transmembrane transporter activity	Extinctions
APLAN	GO:0016782	transferase activity, transferring sulfur-containing groups	Extinctions
APLAN	GO:0004000	adenosine deaminase activity	Extinctions
CFLOR	GO:0003964	RNA-directed DNA polymerase activity	Gains
CFLOR	GO:0034061	DNA polymerase activity	Gains
CFLOR	GO:0016779	nucleotidyltransferase activity	Gains
CFLOR	GO:0140097	catalytic activity, acting on DNA	Gains
CFLOR	GO:0003676	nucleic acid binding	Gains
CFLOR	GO:0004984	olfactory receptor activity	Gains
CFLOR	GO:0070001	aspartic-type peptidase activity	Gains
CFLOR	GO:0004190	aspartic-type endopeptidase activity	Gains
CFLOR	GO:0005549	odorant binding	Gains
CFLOR	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
CFLOR	GO:1901363	heterocyclic compound binding	Gains
CFLOR	GO:0097159	organic cyclic compound binding	Gains
CFLOR	GO:0004518	nuclease activity	Gains
CFLOR	GO:0046914	transition metal ion binding	Gains
CFLOR	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
CFLOR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
CFLOR	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
CFLOR	GO:0008270	zinc ion binding	Gains
CFLOR	GO:0003723	RNA binding	Gains
CFLOR	GO:0004888	transmembrane signaling receptor activity	Gains
CFLOR	GO:0004521	endoribonuclease activity	Gains
CFLOR	GO:0004519	endonuclease activity	Gains
CFLOR	GO:0099600	transmembrane receptor activity	Gains
CFLOR	GO:0004803	transposase activity	Gains
CFLOR	GO:0004497	monooxygenase activity	Gains
CFLOR	GO:0004540	ribonuclease activity	Gains
CFLOR	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
CFLOR	GO:0016740	transferase activity	Gains
CFLOR	GO:0038023	signaling receptor activity	Gains
CFLOR	GO:0140098	catalytic activity, acting on RNA	Gains
CFLOR	GO:0004871	signal transducer activity	Gains
CFLOR	GO:0004930	G-protein coupled receptor activity	Gains
CFLOR	GO:0004104	cholinesterase activity	Gains
CFLOR	GO:0004175	endopeptidase activity	Gains
CFLOR	GO:0003677	DNA binding	Gains
CFLOR	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
CFLOR	GO:0004312	fatty acid synthase activity	Gains
CFLOR	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
CFLOR	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
CFLOR	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
CFLOR	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
CFLOR	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
CFLOR	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
CFLOR	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
CFLOR	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
CFLOR	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
CFLOR	GO:0097747	RNA polymerase activity	Gains
CFLOR	GO:0034062	5'-3' RNA polymerase activity	Gains
CFLOR	GO:0016788	hydrolase activity, acting on ester bonds	Gains
CFLOR	GO:0008174	mRNA methyltransferase activity	Gains
CFLOR	GO:0052689	carboxylic ester hydrolase activity	Gains
CFLOR	GO:0004602	glutathione peroxidase activity	Gains
CFLOR	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
CFLOR	GO:0070330	aromatase activity	Gains
CFLOR	GO:0005506	iron ion binding	Gains
CFLOR	GO:0046906	tetrapyrrole binding	Gains
CFLOR	GO:0004872	receptor activity	Gains
CFLOR	GO:0060089	molecular transducer activity	Gains
CFLOR	GO:0004555	alpha,alpha-trehalase activity	Gains
CFLOR	GO:0003963	RNA-3'-phosphate cyclase activity	Gains
CFLOR	GO:0016420	malonyltransferase activity	Gains
CFLOR	GO:0016419	S-malonyltransferase activity	Gains
CFLOR	GO:0015927	trehalase activity	Gains
CFLOR	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Gains
CFLOR	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	Gains
CFLOR	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
CFLOR	GO:0003990	acetylcholinesterase activity	Gains
CFLOR	GO:0008233	peptidase activity	Gains
CFLOR	GO:0005488	binding	Gains
CFLOR	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
CFLOR	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
CFLOR	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
CFLOR	GO:0004806	triglyceride lipase activity	Gains
CFLOR	GO:0016418	S-acetyltransferase activity	Gains
CFLOR	GO:0031683	G-protein beta/gamma-subunit complex binding	Gains
CFLOR	GO:0004144	diacylglycerol O-acyltransferase activity	Gains
CFLOR	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
CFLOR	GO:0020037	heme binding	Gains
CFLOR	GO:0015926	glucosidase activity	Gains
CFLOR	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
CFLOR	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
CFLOR	GO:0016229	steroid dehydrogenase activity	Gains
CFLOR	GO:0010181	FMN binding	Gains
CFLOR	GO:0003678	DNA helicase activity	Gains
CFLOR	GO:0005527	macrolide binding	Gains
CFLOR	GO:0005528	FK506 binding	Gains
CFLOR	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
CFLOR	GO:0005549	odorant binding	Losses
CFLOR	GO:0099600	transmembrane receptor activity	Losses
CFLOR	GO:0004888	transmembrane signaling receptor activity	Losses
CFLOR	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
CFLOR	GO:0005216	ion channel activity	Losses
CFLOR	GO:0022838	substrate-specific channel activity	Losses
CFLOR	GO:0004984	olfactory receptor activity	Losses
CFLOR	GO:0015267	channel activity	Losses
CFLOR	GO:0022803	passive transmembrane transporter activity	Losses
CFLOR	GO:0004930	G-protein coupled receptor activity	Losses
CFLOR	GO:0060089	molecular transducer activity	Losses
CFLOR	GO:0038023	signaling receptor activity	Losses
CFLOR	GO:0004872	receptor activity	Losses
CFLOR	GO:0022836	gated channel activity	Losses
CFLOR	GO:0004871	signal transducer activity	Losses
CFLOR	GO:0015075	ion transmembrane transporter activity	Losses
CFLOR	GO:0015276	ligand-gated ion channel activity	Losses
CFLOR	GO:0022834	ligand-gated channel activity	Losses
CFLOR	GO:0030553	cGMP binding	Losses
CFLOR	GO:0005230	extracellular ligand-gated ion channel activity	Losses
CFLOR	GO:0005261	cation channel activity	Losses
CFLOR	GO:0003700	DNA binding transcription factor activity	Losses
CFLOR	GO:0005215	transporter activity	Losses
CFLOR	GO:0005118	sevenless binding	Losses
CFLOR	GO:0005179	hormone activity	Losses
CFLOR	GO:0022857	transmembrane transporter activity	Losses
CFLOR	GO:0022891	substrate-specific transmembrane transporter activity	Losses
CFLOR	GO:0004692	cGMP-dependent protein kinase activity	Losses
CFLOR	GO:0019992	diacylglycerol binding	Losses
CFLOR	GO:0030551	cyclic nucleotide binding	Losses
CFLOR	GO:0030545	receptor regulator activity	Losses
CFLOR	GO:0022892	substrate-specific transporter activity	Losses
CFLOR	GO:0032182	ubiquitin-like protein binding	Losses
CFLOR	GO:0008307	structural constituent of muscle	Losses
CFLOR	GO:0022890	inorganic cation transmembrane transporter activity	Losses
CFLOR	GO:0005102	receptor binding	Losses
CFLOR	GO:0004687	myosin light chain kinase activity	Losses
CFLOR	GO:0016840	carbon-nitrogen lyase activity	Losses
CFLOR	GO:0048018	receptor ligand activity	Losses
CFLOR	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
CFLOR	GO:0140110	transcription regulator activity	Losses
CFLOR	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
CFLOR	GO:0005549	odorant binding	Extinctions
CFLOR	GO:0004984	olfactory receptor activity	Extinctions
CFLOR	GO:0004930	G-protein coupled receptor activity	Extinctions
CFLOR	GO:0099600	transmembrane receptor activity	Extinctions
CFLOR	GO:0004888	transmembrane signaling receptor activity	Extinctions
CFLOR	GO:0032182	ubiquitin-like protein binding	Extinctions
CFLOR	GO:0016840	carbon-nitrogen lyase activity	Extinctions
CFLOR	GO:0030545	receptor regulator activity	Extinctions
CFLOR	GO:0005179	hormone activity	Extinctions
CFLOR	GO:0038023	signaling receptor activity	Extinctions
CFLOR	GO:0005509	calcium ion binding	Extinctions
CFLOR	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
CFLOR	GO:0016597	amino acid binding	Extinctions
CFLOR	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
CFLOR	GO:0004871	signal transducer activity	Extinctions
CFLOR	GO:0050797	thymidylate synthase (FAD) activity	Extinctions
CFLOR	GO:0004794	L-threonine ammonia-lyase activity	Extinctions
CFLOR	GO:0005550	pheromone binding	Extinctions
CFLOR	GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	Extinctions
CFLOR	GO:0046403	polynucleotide 3'-phosphatase activity	Extinctions
CFLOR	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	Extinctions
CFLOR	GO:0001888	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Extinctions
CFLOR	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Extinctions
CFLOR	GO:0004528	phosphodiesterase I activity	Extinctions
CFLOR	GO:0005094	Rho GDP-dissociation inhibitor activity	Extinctions
CFLOR	GO:0035529	NADH pyrophosphatase activity	Extinctions
CFLOR	GO:0004056	argininosuccinate lyase activity	Extinctions
CFLOR	GO:0032183	SUMO binding	Extinctions
CFLOR	GO:0008446	GDP-mannose 4,6-dehydratase activity	Extinctions
CFLOR	GO:0016841	ammonia-lyase activity	Extinctions
CFLOR	GO:0008255	ecdysis-triggering hormone activity	Extinctions
CFLOR	GO:0003726	double-stranded RNA adenosine deaminase activity	Extinctions
CFLOR	GO:0003883	CTP synthase activity	Extinctions
CFLOR	GO:0051733	polydeoxyribonucleotide kinase activity	Extinctions
CFLOR	GO:0051734	ATP-dependent polynucleotide kinase activity	Extinctions
BIMPA	GO:0003824	catalytic activity	Gains
BIMPA	GO:0004984	olfactory receptor activity	Gains
BIMPA	GO:0000156	phosphorelay response regulator activity	Gains
BIMPA	GO:0005549	odorant binding	Gains
BIMPA	GO:0004812	aminoacyl-tRNA ligase activity	Gains
BIMPA	GO:0048037	cofactor binding	Gains
BIMPA	GO:0036094	small molecule binding	Gains
BIMPA	GO:0140098	catalytic activity, acting on RNA	Gains
BIMPA	GO:0043168	anion binding	Gains
BIMPA	GO:0016763	transferase activity, transferring pentosyl groups	Gains
BIMPA	GO:0050662	coenzyme binding	Gains
BIMPA	GO:0050661	NADP binding	Gains
BIMPA	GO:0140101	catalytic activity, acting on a tRNA	Gains
BIMPA	GO:0030554	adenyl nucleotide binding	Gains
BIMPA	GO:0017076	purine nucleotide binding	Gains
BIMPA	GO:0005524	ATP binding	Gains
BIMPA	GO:0032559	adenyl ribonucleotide binding	Gains
BIMPA	GO:0032553	ribonucleotide binding	Gains
BIMPA	GO:0016741	transferase activity, transferring one-carbon groups	Gains
BIMPA	GO:0030145	manganese ion binding	Gains
BIMPA	GO:1901265	nucleoside phosphate binding	Gains
BIMPA	GO:0000166	nucleotide binding	Gains
BIMPA	GO:0030976	thiamine pyrophosphate binding	Gains
BIMPA	GO:0043115	precorrin-2 dehydrogenase activity	Gains
BIMPA	GO:0035639	purine ribonucleoside triphosphate binding	Gains
BIMPA	GO:0097367	carbohydrate derivative binding	Gains
BIMPA	GO:0032555	purine ribonucleotide binding	Gains
BIMPA	GO:0016462	pyrophosphatase activity	Gains
BIMPA	GO:0061783	peptidoglycan muralytic activity	Gains
BIMPA	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
BIMPA	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
BIMPA	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
BIMPA	GO:0008173	RNA methyltransferase activity	Gains
BIMPA	GO:0008168	methyltransferase activity	Gains
BIMPA	GO:0043023	ribosomal large subunit binding	Gains
BIMPA	GO:0009922	fatty acid elongase activity	Gains
BIMPA	GO:0008169	C-methyltransferase activity	Gains
BIMPA	GO:0016829	lyase activity	Gains
BIMPA	GO:0017111	nucleoside-triphosphatase activity	Gains
BIMPA	GO:0016853	isomerase activity	Gains
BIMPA	GO:0019842	vitamin binding	Gains
BIMPA	GO:0043022	ribosome binding	Gains
BIMPA	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
BIMPA	GO:0004654	polyribonucleotide nucleotidyltransferase activity	Gains
BIMPA	GO:0004930	G-protein coupled receptor activity	Gains
BIMPA	GO:0031406	carboxylic acid binding	Gains
BIMPA	GO:0043177	organic acid binding	Gains
BIMPA	GO:0140102	catalytic activity, acting on a rRNA	Gains
BIMPA	GO:0008649	rRNA methyltransferase activity	Gains
BIMPA	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
BIMPA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
BIMPA	GO:0004813	alanine-tRNA ligase activity	Gains
BIMPA	GO:0002161	aminoacyl-tRNA editing activity	Gains
BIMPA	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
BIMPA	GO:0016830	carbon-carbon lyase activity	Gains
BIMPA	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
BIMPA	GO:0019205	nucleobase-containing compound kinase activity	Gains
BIMPA	GO:0004312	fatty acid synthase activity	Gains
BIMPA	GO:0016854	racemase and epimerase activity	Gains
BIMPA	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
BIMPA	GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
BIMPA	GO:0019104	DNA N-glycosylase activity	Gains
BIMPA	GO:0030515	snoRNA binding	Gains
BIMPA	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Gains
BIMPA	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
BIMPA	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
BIMPA	GO:0003964	RNA-directed DNA polymerase activity	Losses
BIMPA	GO:0034061	DNA polymerase activity	Losses
BIMPA	GO:0004190	aspartic-type endopeptidase activity	Losses
BIMPA	GO:0070001	aspartic-type peptidase activity	Losses
BIMPA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
BIMPA	GO:0004521	endoribonuclease activity	Losses
BIMPA	GO:0003676	nucleic acid binding	Losses
BIMPA	GO:0140097	catalytic activity, acting on DNA	Losses
BIMPA	GO:0004519	endonuclease activity	Losses
BIMPA	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
BIMPA	GO:0016779	nucleotidyltransferase activity	Losses
BIMPA	GO:0003677	DNA binding	Losses
BIMPA	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
BIMPA	GO:0004540	ribonuclease activity	Losses
BIMPA	GO:0008270	zinc ion binding	Losses
BIMPA	GO:0003723	RNA binding	Losses
BIMPA	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
BIMPA	GO:0060089	molecular transducer activity	Losses
BIMPA	GO:0043565	sequence-specific DNA binding	Losses
BIMPA	GO:0004518	nuclease activity	Losses
BIMPA	GO:0043169	cation binding	Losses
BIMPA	GO:0003700	DNA binding transcription factor activity	Losses
BIMPA	GO:0004857	enzyme inhibitor activity	Losses
BIMPA	GO:0004526	ribonuclease P activity	Losses
BIMPA	GO:0032450	maltose alpha-glucosidase activity	Losses
BIMPA	GO:0097472	cyclin-dependent protein kinase activity	Losses
BIMPA	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Losses
BIMPA	GO:0046914	transition metal ion binding	Losses
BIMPA	GO:0004888	transmembrane signaling receptor activity	Losses
BIMPA	GO:0098772	molecular function regulator	Losses
BIMPA	GO:0030414	peptidase inhibitor activity	Losses
BIMPA	GO:0008527	taste receptor activity	Losses
BIMPA	GO:0090599	alpha-glucosidase activity	Losses
BIMPA	GO:0046872	metal ion binding	Losses
BIMPA	GO:0030234	enzyme regulator activity	Losses
BIMPA	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
BIMPA	GO:0038023	signaling receptor activity	Losses
BIMPA	GO:0099600	transmembrane receptor activity	Losses
BIMPA	GO:0061134	peptidase regulator activity	Losses
BIMPA	GO:0004803	transposase activity	Losses
BIMPA	GO:0004549	tRNA-specific ribonuclease activity	Losses
BIMPA	GO:0015926	glucosidase activity	Losses
BIMPA	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
BIMPA	GO:0005436	sodium:phosphate symporter activity	Losses
BIMPA	GO:0008873	gluconate 2-dehydrogenase activity	Losses
BIMPA	GO:0008875	gluconate dehydrogenase activity	Losses
BIMPA	GO:0003680	AT DNA binding	Losses
BIMPA	GO:0016208	AMP binding	Losses
BIMPA	GO:0032028	myosin head/neck binding	Losses
BIMPA	GO:0031489	myosin V binding	Losses
BIMPA	GO:0090600	alpha-1,3-glucosidase activity	Losses
BIMPA	GO:0016534	cyclin-dependent protein kinase 5 activator activity	Losses
BIMPA	GO:0070854	myosin VI heavy chain binding	Losses
BIMPA	GO:0070855	myosin VI head/neck binding	Losses
BIMPA	GO:0004995	tachykinin receptor activity	Losses
BIMPA	GO:0033919	glucan 1,3-alpha-glucosidase activity	Losses
BIMPA	GO:0033904	dextranase activity	Losses
BIMPA	GO:0052917	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	Losses
BIMPA	GO:0004866	endopeptidase inhibitor activity	Losses
BIMPA	GO:0004930	G-protein coupled receptor activity	Losses
BIMPA	GO:1901363	heterocyclic compound binding	Losses
BIMPA	GO:0097159	organic cyclic compound binding	Losses
BIMPA	GO:0031490	chromatin DNA binding	Losses
BIMPA	GO:0061135	endopeptidase regulator activity	Losses
BIMPA	GO:0008061	chitin binding	Losses
BIMPA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
BIMPA	GO:0005488	binding	Losses
BIMPA	GO:0008233	peptidase activity	Losses
BIMPA	GO:0004871	signal transducer activity	Losses
BIMPA	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
BIMPA	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
BIMPA	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
BIMPA	GO:0034061	DNA polymerase activity	Extinctions
BIMPA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
BIMPA	GO:0070001	aspartic-type peptidase activity	Extinctions
BIMPA	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
BIMPA	GO:0003676	nucleic acid binding	Extinctions
BIMPA	GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
BIMPA	GO:0004857	enzyme inhibitor activity	Extinctions
BIMPA	GO:0008061	chitin binding	Extinctions
BIMPA	GO:0098772	molecular function regulator	Extinctions
BIMPA	GO:0030234	enzyme regulator activity	Extinctions
BIMPA	GO:0003735	structural constituent of ribosome	Extinctions
BIMPA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
BIMPA	GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
BIMPA	GO:0008875	gluconate dehydrogenase activity	Extinctions
BIMPA	GO:0090600	alpha-1,3-glucosidase activity	Extinctions
BIMPA	GO:0016534	cyclin-dependent protein kinase 5 activator activity	Extinctions
BIMPA	GO:0033919	glucan 1,3-alpha-glucosidase activity	Extinctions
BIMPA	GO:0033904	dextranase activity	Extinctions
BIMPA	GO:0052917	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	Extinctions
BIMPA	GO:0003723	RNA binding	Extinctions
BIMPA	GO:0030414	peptidase inhibitor activity	Extinctions
BIMPA	GO:0016779	nucleotidyltransferase activity	Extinctions
BIMPA	GO:0140097	catalytic activity, acting on DNA	Extinctions
BIMPA	GO:0004867	serine-type endopeptidase inhibitor activity	Extinctions
BIMPA	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
BIMPA	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Extinctions
BIMPA	GO:0043539	protein serine/threonine kinase activator activity	Extinctions
BIMPA	GO:0004798	thymidylate kinase activity	Extinctions
BIMPA	GO:0019905	syntaxin binding	Extinctions
BIMPA	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	Extinctions
BIMPA	GO:0000009	alpha-1,6-mannosyltransferase activity	Extinctions
BIMPA	GO:0061134	peptidase regulator activity	Extinctions
BIMPA	GO:0004842	ubiquitin-protein transferase activity	Extinctions
BIMPA	GO:0097472	cyclin-dependent protein kinase activity	Extinctions
BIMPA	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Extinctions
BIMPA	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
BIMPA	GO:0005509	calcium ion binding	Extinctions
BIMPA	GO:0004521	endoribonuclease activity	Extinctions
BIMPA	GO:0003677	DNA binding	Extinctions
HY9	GO:0003777	microtubule motor activity	Gains
HY9	GO:0003774	motor activity	Gains
HY9	GO:0016040	glutamate synthase (NADH) activity	Gains
HY9	GO:0042071	leucokinin receptor activity	Gains
HY9	GO:0042736	NADH kinase activity	Gains
HY9	GO:0004355	glutamate synthase (NADPH) activity	Gains
HY9	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Gains
HY9	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity	Gains
HY9	GO:0003867	4-aminobutyrate transaminase activity	Gains
HY9	GO:0015930	glutamate synthase activity	Gains
HY9	GO:0003844	1,4-alpha-glucan branching enzyme activity	Gains
HY9	GO:0045181	glutamate synthase activity, NAD(P)H as acceptor	Gains
HY9	GO:0033883	pyridoxal phosphatase activity	Gains
HY9	GO:0004363	glutathione synthase activity	Gains
HY9	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Gains
HY9	GO:0005212	structural constituent of eye lens	Gains
HY9	GO:0043142	single-stranded DNA-dependent ATPase activity	Gains
HY9	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Gains
HY9	GO:0050839	cell adhesion molecule binding	Gains
HY9	GO:0001103	RNA polymerase II repressing transcription factor binding	Gains
HY9	GO:0005160	transforming growth factor beta receptor binding	Gains
HY9	GO:0005178	integrin binding	Gains
HY9	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
HY9	GO:0008527	taste receptor activity	Gains
HY9	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Gains
HY9	GO:0046592	polyamine oxidase activity	Gains
HY9	GO:0005126	cytokine receptor binding	Gains
HY9	GO:0008233	peptidase activity	Gains
HY9	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY9	GO:0034061	DNA polymerase activity	Losses
HY9	GO:0016779	nucleotidyltransferase activity	Losses
HY9	GO:0140097	catalytic activity, acting on DNA	Losses
HY9	GO:0003676	nucleic acid binding	Losses
HY9	GO:0004518	nuclease activity	Losses
HY9	GO:0003723	RNA binding	Losses
HY9	GO:0004984	olfactory receptor activity	Losses
HY9	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY9	GO:0004519	endonuclease activity	Losses
HY9	GO:0099600	transmembrane receptor activity	Losses
HY9	GO:0046872	metal ion binding	Losses
HY9	GO:0043169	cation binding	Losses
HY9	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY9	GO:0046914	transition metal ion binding	Losses
HY9	GO:0004888	transmembrane signaling receptor activity	Losses
HY9	GO:0004872	receptor activity	Losses
HY9	GO:0038023	signaling receptor activity	Losses
HY9	GO:0005549	odorant binding	Losses
HY9	GO:0070001	aspartic-type peptidase activity	Losses
HY9	GO:0004190	aspartic-type endopeptidase activity	Losses
HY9	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HY9	GO:0060089	molecular transducer activity	Losses
HY9	GO:0004871	signal transducer activity	Losses
HY9	GO:0016803	ether hydrolase activity	Losses
HY9	GO:0008270	zinc ion binding	Losses
HY9	GO:0003677	DNA binding	Losses
HY9	GO:0004930	G-protein coupled receptor activity	Losses
HY9	GO:0004597	peptide-aspartate beta-dioxygenase activity	Losses
HY9	GO:0016801	hydrolase activity, acting on ether bonds	Losses
HY9	GO:0003678	DNA helicase activity	Losses
HY9	GO:1901363	heterocyclic compound binding	Losses
HY9	GO:0097159	organic cyclic compound binding	Losses
HY9	GO:0004521	endoribonuclease activity	Losses
HY9	GO:0004463	leukotriene-A4 hydrolase activity	Losses
HY9	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY9	GO:0030246	carbohydrate binding	Losses
HY9	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY9	GO:0004784	superoxide dismutase activity	Losses
HY9	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
HY9	GO:0005215	transporter activity	Losses
HY9	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY9	GO:0022857	transmembrane transporter activity	Losses
HY9	GO:0016740	transferase activity	Losses
HY9	GO:0008233	peptidase activity	Losses
HY9	GO:0016787	hydrolase activity	Losses
HY9	GO:0016209	antioxidant activity	Losses
HY9	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
HY9	GO:0008237	metallopeptidase activity	Losses
HY9	GO:0004540	ribonuclease activity	Losses
HY9	GO:0015002	heme-copper terminal oxidase activity	Losses
HY9	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
HY9	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
HY9	GO:0004129	cytochrome-c oxidase activity	Losses
HY9	GO:0004175	endopeptidase activity	Losses
HY9	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
HY9	GO:0005507	copper ion binding	Losses
HY9	GO:0015296	anion:cation symporter activity	Losses
HY9	GO:0003887	DNA-directed DNA polymerase activity	Losses
HY9	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	Losses
HY9	GO:0070576	vitamin D 24-hydroxylase activity	Losses
HY9	GO:0016019	peptidoglycan receptor activity	Losses
HY9	GO:0046332	SMAD binding	Losses
HY9	GO:0032093	SAM domain binding	Losses
HY9	GO:0016936	galactoside binding	Losses
HY9	GO:0004598	peptidylamidoglycolate lyase activity	Losses
HY9	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
HY9	GO:0052870	tocopherol omega-hydroxylase activity	Losses
HY9	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
HY9	GO:0001875	lipopolysaccharide receptor activity	Losses
HY9	GO:0018738	S-formylglutathione hydrolase activity	Losses
HY9	GO:0015204	urea transmembrane transporter activity	Losses
HY9	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
HY9	GO:0016361	activin receptor activity, type I	Losses
HY9	GO:0005025	transforming growth factor beta receptor activity, type I	Losses
HY9	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
HY9	GO:0001614	purinergic nucleotide receptor activity	Losses
HY9	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
HY9	GO:0004092	carnitine O-acetyltransferase activity	Losses
HY9	GO:0004062	aryl sulfotransferase activity	Losses
HY9	GO:0004027	alcohol sulfotransferase activity	Losses
HY9	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
HY9	GO:0034584	piRNA binding	Losses
HY9	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY9	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY9	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
HY9	GO:0032183	SUMO binding	Losses
HY9	GO:0070410	co-SMAD binding	Losses
HY9	GO:0005436	sodium:phosphate symporter activity	Losses
HY9	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
HY9	GO:0004321	fatty-acyl-CoA synthase activity	Losses
HY9	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
HY9	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
HY9	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
HY9	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
HY9	GO:0003720	telomerase activity	Losses
HY9	GO:0003721	telomerase RNA reverse transcriptase activity	Losses
HY9	GO:0050431	transforming growth factor beta binding	Losses
HY9	GO:0004301	epoxide hydrolase activity	Losses
HY9	GO:0004304	estrone sulfotransferase activity	Losses
HY9	GO:0017151	DEAD/H-box RNA helicase binding	Losses
HY9	GO:0004423	iduronate-2-sulfatase activity	Losses
HY9	GO:0050111	mycocerosate synthase activity	Losses
HY9	GO:0016502	nucleotide receptor activity	Losses
HY9	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
HY9	GO:0032500	muramyl dipeptide binding	Losses
HY9	GO:0001871	pattern binding	Losses
HY9	GO:0030247	polysaccharide binding	Losses
HY9	GO:0008199	ferric iron binding	Losses
HY9	GO:0005198	structural molecule activity	Losses
HY9	GO:0052689	carboxylic ester hydrolase activity	Losses
HY9	GO:0005488	binding	Losses
HY9	GO:0008238	exopeptidase activity	Losses
HY9	GO:0015293	symporter activity	Losses
HY9	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY9	GO:0034061	DNA polymerase activity	Extinctions
HY9	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY9	GO:0016779	nucleotidyltransferase activity	Extinctions
HY9	GO:0003676	nucleic acid binding	Extinctions
HY9	GO:0004984	olfactory receptor activity	Extinctions
HY9	GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
HY9	GO:0005549	odorant binding	Extinctions
HY9	GO:0003678	DNA helicase activity	Extinctions
HY9	GO:0099600	transmembrane receptor activity	Extinctions
HY9	GO:0004930	G-protein coupled receptor activity	Extinctions
HY9	GO:0015002	heme-copper terminal oxidase activity	Extinctions
HY9	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
HY9	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
HY9	GO:0004129	cytochrome-c oxidase activity	Extinctions
HY9	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY9	GO:0004872	receptor activity	Extinctions
HY9	GO:0003723	RNA binding	Extinctions
HY9	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
HY9	GO:0060089	molecular transducer activity	Extinctions
HY9	GO:0008199	ferric iron binding	Extinctions
HY9	GO:0004871	signal transducer activity	Extinctions
HY9	GO:0038023	signaling receptor activity	Extinctions
HY9	GO:0015276	ligand-gated ion channel activity	Extinctions
HY9	GO:0022834	ligand-gated channel activity	Extinctions
HY9	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
HY9	GO:0016936	galactoside binding	Extinctions
HY9	GO:0015204	urea transmembrane transporter activity	Extinctions
HY9	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
HY9	GO:0004092	carnitine O-acetyltransferase activity	Extinctions
HY9	GO:0032183	SUMO binding	Extinctions
HY9	GO:0003720	telomerase activity	Extinctions
HY9	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
HY9	GO:0004423	iduronate-2-sulfatase activity	Extinctions
HY9	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
HY9	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
HY9	GO:0004519	endonuclease activity	Extinctions
HY9	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
HY9	GO:0004386	helicase activity	Extinctions
HY9	GO:0051213	dioxygenase activity	Extinctions
HY9	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
HY9	GO:0008508	bile acid:sodium symporter activity	Extinctions
HY9	GO:0000146	microfilament motor activity	Extinctions
HY9	GO:0015125	bile acid transmembrane transporter activity	Extinctions
HY9	GO:0004657	proline dehydrogenase activity	Extinctions
HY9	GO:0008198	ferrous iron binding	Extinctions
HY9	GO:0004102	choline O-acetyltransferase activity	Extinctions
HY9	GO:0030246	carbohydrate binding	Extinctions
HY9	GO:0003677	DNA binding	Extinctions
OTAUR	GO:0003964	RNA-directed DNA polymerase activity	Gains
OTAUR	GO:0003676	nucleic acid binding	Gains
OTAUR	GO:0016779	nucleotidyltransferase activity	Gains
OTAUR	GO:0003677	DNA binding	Gains
OTAUR	GO:0034061	DNA polymerase activity	Gains
OTAUR	GO:0097159	organic cyclic compound binding	Gains
OTAUR	GO:1901363	heterocyclic compound binding	Gains
OTAUR	GO:0140097	catalytic activity, acting on DNA	Gains
OTAUR	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
OTAUR	GO:0097747	RNA polymerase activity	Gains
OTAUR	GO:0034062	5'-3' RNA polymerase activity	Gains
OTAUR	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
OTAUR	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
OTAUR	GO:0005549	odorant binding	Gains
OTAUR	GO:0032934	sterol binding	Gains
OTAUR	GO:0070001	aspartic-type peptidase activity	Gains
OTAUR	GO:0004190	aspartic-type endopeptidase activity	Gains
OTAUR	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Gains
OTAUR	GO:0099600	transmembrane receptor activity	Gains
OTAUR	GO:0003682	chromatin binding	Gains
OTAUR	GO:0004888	transmembrane signaling receptor activity	Gains
OTAUR	GO:0038023	signaling receptor activity	Gains
OTAUR	GO:0005496	steroid binding	Gains
OTAUR	GO:0033868	Goodpasture-antigen-binding protein kinase activity	Gains
OTAUR	GO:0046974	histone methyltransferase activity (H3-K9 specific)	Gains
OTAUR	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
OTAUR	GO:0004984	olfactory receptor activity	Gains
OTAUR	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
OTAUR	GO:0042302	structural constituent of cuticle	Gains
OTAUR	GO:0004872	receptor activity	Gains
OTAUR	GO:0004776	succinate-CoA ligase (GDP-forming) activity	Gains
OTAUR	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Gains
OTAUR	GO:0004832	valine-tRNA ligase activity	Gains
OTAUR	GO:0035586	purinergic receptor activity	Gains
OTAUR	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Gains
OTAUR	GO:0008449	N-acetylglucosamine-6-sulfatase activity	Gains
OTAUR	GO:0004370	glycerol kinase activity	Gains
OTAUR	GO:0004930	G-protein coupled receptor activity	Gains
OTAUR	GO:0016408	C-acyltransferase activity	Gains
OTAUR	GO:0015085	calcium ion transmembrane transporter activity	Gains
OTAUR	GO:0022892	substrate-specific transporter activity	Gains
OTAUR	GO:0099094	ligand-gated cation channel activity	Gains
OTAUR	GO:0004687	myosin light chain kinase activity	Gains
OTAUR	GO:0004619	phosphoglycerate mutase activity	Gains
OTAUR	GO:0004012	phospholipid-translocating ATPase activity	Gains
OTAUR	GO:0043178	alcohol binding	Gains
OTAUR	GO:0015171	amino acid transmembrane transporter activity	Gains
OTAUR	GO:0005215	transporter activity	Gains
OTAUR	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
OTAUR	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
OTAUR	GO:0004983	neuropeptide Y receptor activity	Gains
OTAUR	GO:0046914	transition metal ion binding	Gains
OTAUR	GO:0005319	lipid transporter activity	Gains
OTAUR	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
OTAUR	GO:0008270	zinc ion binding	Gains
OTAUR	GO:0003964	RNA-directed DNA polymerase activity	Losses
OTAUR	GO:0034061	DNA polymerase activity	Losses
OTAUR	GO:0140097	catalytic activity, acting on DNA	Losses
OTAUR	GO:0016779	nucleotidyltransferase activity	Losses
OTAUR	GO:0005212	structural constituent of eye lens	Losses
OTAUR	GO:0046423	allene-oxide cyclase activity	Losses
OTAUR	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
OTAUR	GO:0051213	dioxygenase activity	Losses
OTAUR	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Losses
OTAUR	GO:0008812	choline dehydrogenase activity	Losses
OTAUR	GO:0005000	vasopressin receptor activity	Losses
OTAUR	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Losses
OTAUR	GO:0004185	serine-type carboxypeptidase activity	Losses
OTAUR	GO:0015631	tubulin binding	Losses
OTAUR	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
OTAUR	GO:0070008	serine-type exopeptidase activity	Losses
OTAUR	GO:0004658	propionyl-CoA carboxylase activity	Losses
OTAUR	GO:0070717	poly-purine tract binding	Losses
OTAUR	GO:0019894	kinesin binding	Losses
OTAUR	GO:0008430	selenium binding	Losses
OTAUR	GO:0008143	poly(A) binding	Losses
OTAUR	GO:0004181	metallocarboxypeptidase activity	Losses
OTAUR	GO:0008017	microtubule binding	Losses
OTAUR	GO:0004180	carboxypeptidase activity	Losses
OTAUR	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
OTAUR	GO:0004322	ferroxidase activity	Losses
OTAUR	GO:0016597	amino acid binding	Losses
OTAUR	GO:0015179	L-amino acid transmembrane transporter activity	Losses
OTAUR	GO:0022891	substrate-specific transmembrane transporter activity	Losses
OTAUR	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
OTAUR	GO:0140097	catalytic activity, acting on DNA	Extinctions
OTAUR	GO:0051213	dioxygenase activity	Extinctions
OTAUR	GO:0034061	DNA polymerase activity	Extinctions
OTAUR	GO:0046423	allene-oxide cyclase activity	Extinctions
OTAUR	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Extinctions
OTAUR	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
OTAUR	GO:0016779	nucleotidyltransferase activity	Extinctions
OTAUR	GO:0008812	choline dehydrogenase activity	Extinctions
OTAUR	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Extinctions
OTAUR	GO:0004658	propionyl-CoA carboxylase activity	Extinctions
OTAUR	GO:0070717	poly-purine tract binding	Extinctions
OTAUR	GO:0019894	kinesin binding	Extinctions
OTAUR	GO:0008430	selenium binding	Extinctions
OTAUR	GO:0008143	poly(A) binding	Extinctions
OTAUR	GO:0016597	amino acid binding	Extinctions
OTAUR	GO:0003678	DNA helicase activity	Extinctions
OTAUR	GO:0015631	tubulin binding	Extinctions
OTAUR	GO:0008066	glutamate receptor activity	Extinctions
OTAUR	GO:0140104	molecular carrier activity	Extinctions
OTAUR	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Extinctions
OTAUR	GO:0031406	carboxylic acid binding	Extinctions
OTAUR	GO:0043177	organic acid binding	Extinctions
OTAUR	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
OTAUR	GO:0050700	CARD domain binding	Extinctions
OTAUR	GO:0008531	riboflavin kinase activity	Extinctions
OTAUR	GO:0016595	glutamate binding	Extinctions
OTAUR	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Extinctions
OTAUR	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Extinctions
OTAUR	GO:0050577	GDP-L-fucose synthase activity	Extinctions
OTAUR	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
OTAUR	GO:0004566	beta-glucuronidase activity	Extinctions
OTAUR	GO:0004567	beta-mannosidase activity	Extinctions
OTAUR	GO:0035755	cardiolipin hydrolase activity	Extinctions
OTAUR	GO:0033677	DNA/RNA helicase activity	Extinctions
OTAUR	GO:0031177	phosphopantetheine binding	Extinctions
OTAUR	GO:0003920	GMP reductase activity	Extinctions
OTAUR	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Extinctions
OTAUR	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
OTAUR	GO:0047444	N-acylneuraminate-9-phosphate synthase activity	Extinctions
OTAUR	GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
OTAUR	GO:0033981	D-dopachrome decarboxylase activity	Extinctions
OTAUR	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
OTAUR	GO:0000036	acyl carrier activity	Extinctions
OTAUR	GO:0051192	prosthetic group binding	Extinctions
OTAUR	GO:0050462	N-acetylneuraminate synthase activity	Extinctions
OTAUR	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
OTAUR	GO:0034986	iron chaperone activity	Extinctions
OTAUR	GO:0004411	homogentisate 1,2-dioxygenase activity	Extinctions
OTAUR	GO:0045294	alpha-catenin binding	Extinctions
OTAUR	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Extinctions
OTAUR	GO:0008743	L-threonine 3-dehydrogenase activity	Extinctions
HY17	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY17	GO:0034061	DNA polymerase activity	Gains
HY17	GO:0140097	catalytic activity, acting on DNA	Gains
HY17	GO:0004519	endonuclease activity	Gains
HY17	GO:0016779	nucleotidyltransferase activity	Gains
HY17	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY17	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY17	GO:0004521	endoribonuclease activity	Gains
HY17	GO:0004518	nuclease activity	Gains
HY17	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY17	GO:0004190	aspartic-type endopeptidase activity	Gains
HY17	GO:0070001	aspartic-type peptidase activity	Gains
HY17	GO:0004540	ribonuclease activity	Gains
HY17	GO:0003676	nucleic acid binding	Gains
HY17	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
HY17	GO:0004950	chemokine receptor activity	Gains
HY17	GO:0008188	neuropeptide receptor activity	Gains
HY17	GO:0003723	RNA binding	Gains
HY17	GO:0004896	cytokine receptor activity	Gains
HY17	GO:0008528	G-protein coupled peptide receptor activity	Gains
HY17	GO:0004984	olfactory receptor activity	Gains
HY17	GO:0001653	peptide receptor activity	Gains
HY17	GO:0003677	DNA binding	Gains
HY17	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Gains
HY17	GO:0005549	odorant binding	Gains
HY17	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
HY17	GO:0004930	G-protein coupled receptor activity	Gains
HY17	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Gains
HY17	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
HY17	GO:0008270	zinc ion binding	Gains
HY17	GO:0038023	signaling receptor activity	Gains
HY17	GO:0004803	transposase activity	Gains
HY17	GO:0004888	transmembrane signaling receptor activity	Gains
HY17	GO:0140098	catalytic activity, acting on RNA	Gains
HY17	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HY17	GO:0016788	hydrolase activity, acting on ester bonds	Gains
HY17	GO:0099600	transmembrane receptor activity	Gains
HY17	GO:0004175	endopeptidase activity	Gains
HY17	GO:0004871	signal transducer activity	Gains
HY17	GO:0008233	peptidase activity	Gains
HY17	GO:0004983	neuropeptide Y receptor activity	Gains
HY17	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY17	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY17	GO:0047536	2-aminoadipate transaminase activity	Gains
HY17	GO:0042654	ecdysis-triggering hormone receptor activity	Gains
HY17	GO:0016208	AMP binding	Gains
HY17	GO:0004995	tachykinin receptor activity	Gains
HY17	GO:0004997	thyrotropin-releasing hormone receptor activity	Gains
HY17	GO:0008477	purine nucleosidase activity	Gains
HY17	GO:0005125	cytokine activity	Gains
HY17	GO:0046914	transition metal ion binding	Gains
HY17	GO:0004872	receptor activity	Gains
HY17	GO:0060089	molecular transducer activity	Gains
HY17	GO:0004555	alpha,alpha-trehalase activity	Gains
HY17	GO:0003987	acetate-CoA ligase activity	Gains
HY17	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
HY17	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
HY17	GO:0015927	trehalase activity	Gains
HY17	GO:0005199	structural constituent of cell wall	Gains
HY17	GO:0016787	hydrolase activity	Gains
HY17	GO:0009922	fatty acid elongase activity	Gains
HY17	GO:0004736	pyruvate carboxylase activity	Gains
HY17	GO:0016740	transferase activity	Gains
HY17	GO:0016015	morphogen activity	Gains
HY17	GO:0004144	diacylglycerol O-acyltransferase activity	Gains
HY17	GO:0061659	ubiquitin-like protein ligase activity	Gains
HY17	GO:0061630	ubiquitin protein ligase activity	Gains
HY17	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Gains
HY17	GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
HY17	GO:0016874	ligase activity	Gains
HY17	GO:0004104	cholinesterase activity	Losses
HY17	GO:0003990	acetylcholinesterase activity	Losses
HY17	GO:0004337	geranyltranstransferase activity	Losses
HY17	GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
HY17	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
HY17	GO:0070594	juvenile hormone response element binding	Losses
HY17	GO:0052689	carboxylic ester hydrolase activity	Losses
HY17	GO:0004161	dimethylallyltranstransferase activity	Losses
HY17	GO:0019992	diacylglycerol binding	Losses
HY17	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Losses
HY17	GO:0003960	NADPH:quinone reductase activity	Losses
HY17	GO:0016174	NAD(P)H oxidase activity	Losses
HY17	GO:0003796	lysozyme activity	Losses
HY17	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
HY17	GO:0042826	histone deacetylase binding	Losses
HY17	GO:0031418	L-ascorbic acid binding	Losses
HY17	GO:0043565	sequence-specific DNA binding	Losses
HY17	GO:0003960	NADPH:quinone reductase activity	Extinctions
HY17	GO:0003796	lysozyme activity	Extinctions
HY17	GO:0042826	histone deacetylase binding	Extinctions
HY17	GO:0031418	L-ascorbic acid binding	Extinctions
HY17	GO:0043565	sequence-specific DNA binding	Extinctions
HY17	GO:0032440	2-alkenal reductase [NAD(P)] activity	Extinctions
HY17	GO:0003677	DNA binding	Extinctions
HY17	GO:0048029	monosaccharide binding	Extinctions
HY17	GO:0061783	peptidoglycan muralytic activity	Extinctions
HY17	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Extinctions
HY17	GO:0003700	DNA binding transcription factor activity	Extinctions
HY17	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	Extinctions
HY17	GO:0016491	oxidoreductase activity	Extinctions
HY17	GO:0043177	organic acid binding	Extinctions
HY17	GO:0031406	carboxylic acid binding	Extinctions
HY17	GO:0003676	nucleic acid binding	Extinctions
DPSEU	GO:0003964	RNA-directed DNA polymerase activity	Gains
DPSEU	GO:0034061	DNA polymerase activity	Gains
DPSEU	GO:0016779	nucleotidyltransferase activity	Gains
DPSEU	GO:0140097	catalytic activity, acting on DNA	Gains
DPSEU	GO:0004190	aspartic-type endopeptidase activity	Gains
DPSEU	GO:0070001	aspartic-type peptidase activity	Gains
DPSEU	GO:0046914	transition metal ion binding	Gains
DPSEU	GO:0004175	endopeptidase activity	Gains
DPSEU	GO:0008233	peptidase activity	Gains
DPSEU	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DPSEU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DPSEU	GO:0008270	zinc ion binding	Gains
DPSEU	GO:0004984	olfactory receptor activity	Gains
DPSEU	GO:0046872	metal ion binding	Gains
DPSEU	GO:0004298	threonine-type endopeptidase activity	Gains
DPSEU	GO:0070003	threonine-type peptidase activity	Gains
DPSEU	GO:0043169	cation binding	Gains
DPSEU	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
DPSEU	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
DPSEU	GO:0004521	endoribonuclease activity	Gains
DPSEU	GO:0004842	ubiquitin-protein transferase activity	Gains
DPSEU	GO:0004519	endonuclease activity	Gains
DPSEU	GO:0005198	structural molecule activity	Gains
DPSEU	GO:0019787	ubiquitin-like protein transferase activity	Gains
DPSEU	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
DPSEU	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
DPSEU	GO:0004890	GABA-A receptor activity	Gains
DPSEU	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Gains
DPSEU	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
DPSEU	GO:0031418	L-ascorbic acid binding	Gains
DPSEU	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DPSEU	GO:0019798	procollagen-proline dioxygenase activity	Gains
DPSEU	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DPSEU	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Gains
DPSEU	GO:0004866	endopeptidase inhibitor activity	Gains
DPSEU	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
DPSEU	GO:0048029	monosaccharide binding	Gains
DPSEU	GO:0005506	iron ion binding	Gains
DPSEU	GO:0031543	peptidyl-proline dioxygenase activity	Gains
DPSEU	GO:0003990	acetylcholinesterase activity	Gains
DPSEU	GO:0061135	endopeptidase regulator activity	Gains
DPSEU	GO:0140096	catalytic activity, acting on a protein	Gains
DPSEU	GO:0005549	odorant binding	Gains
DPSEU	GO:0038023	signaling receptor activity	Gains
DPSEU	GO:0003723	RNA binding	Gains
DPSEU	GO:0001103	RNA polymerase II repressing transcription factor binding	Gains
DPSEU	GO:0004540	ribonuclease activity	Gains
DPSEU	GO:0019842	vitamin binding	Gains
DPSEU	GO:0003676	nucleic acid binding	Gains
DPSEU	GO:0030246	carbohydrate binding	Gains
DPSEU	GO:0031406	carboxylic acid binding	Gains
DPSEU	GO:0043177	organic acid binding	Gains
DPSEU	GO:0004104	cholinesterase activity	Gains
DPSEU	GO:0051213	dioxygenase activity	Gains
DPSEU	GO:0004888	transmembrane signaling receptor activity	Gains
DPSEU	GO:0030414	peptidase inhibitor activity	Gains
DPSEU	GO:0004176	ATP-dependent peptidase activity	Gains
DPSEU	GO:0004687	myosin light chain kinase activity	Gains
DPSEU	GO:0047915	ganglioside galactosyltransferase activity	Gains
DPSEU	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
DPSEU	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Gains
DPSEU	GO:0016881	acid-amino acid ligase activity	Gains
DPSEU	GO:0099600	transmembrane receptor activity	Gains
DPSEU	GO:0004518	nuclease activity	Gains
DPSEU	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
DPSEU	GO:0004872	receptor activity	Gains
DPSEU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
DPSEU	GO:0004705	JUN kinase activity	Losses
DPSEU	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
DPSEU	GO:0050591	quinine 3-monooxygenase activity	Losses
DPSEU	GO:0016909	SAP kinase activity	Losses
DPSEU	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Losses
DPSEU	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
DPSEU	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Losses
DPSEU	GO:0016174	NAD(P)H oxidase activity	Losses
DPSEU	GO:0004971	AMPA glutamate receptor activity	Losses
DPSEU	GO:0004806	triglyceride lipase activity	Losses
DPSEU	GO:0004707	MAP kinase activity	Losses
DPSEU	GO:0004602	glutathione peroxidase activity	Losses
DPSEU	GO:0015276	ligand-gated ion channel activity	Losses
DPSEU	GO:0022834	ligand-gated channel activity	Losses
DPSEU	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
DPSEU	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
DPSEU	GO:0070330	aromatase activity	Losses
DPSEU	GO:0016491	oxidoreductase activity	Losses
DPSEU	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
DPSEU	GO:0004601	peroxidase activity	Losses
DPSEU	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
DPSEU	GO:0003837	beta-ureidopropionase activity	Losses
DPSEU	GO:0004796	thromboxane-A synthase activity	Losses
DPSEU	GO:0047696	beta-adrenergic receptor kinase activity	Losses
DPSEU	GO:0004747	ribokinase activity	Losses
DPSEU	GO:0018833	DDT-dehydrochlorinase activity	Losses
DPSEU	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Losses
DPSEU	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
DPSEU	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Losses
DPSEU	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
DPSEU	GO:0008048	calcium sensitive guanylate cyclase activator activity	Losses
DPSEU	GO:0004097	catechol oxidase activity	Losses
DPSEU	GO:0010851	cyclase regulator activity	Losses
DPSEU	GO:0010853	cyclase activator activity	Losses
DPSEU	GO:0004014	adenosylmethionine decarboxylase activity	Losses
DPSEU	GO:0042165	neurotransmitter binding	Losses
DPSEU	GO:0042166	acetylcholine binding	Losses
DPSEU	GO:0008331	high voltage-gated calcium channel activity	Losses
DPSEU	GO:0008420	CTD phosphatase activity	Losses
DPSEU	GO:0030250	guanylate cyclase activator activity	Losses
DPSEU	GO:0030249	guanylate cyclase regulator activity	Losses
DPSEU	GO:0036263	L-DOPA monooxygenase activity	Losses
DPSEU	GO:0036264	dopamine monooxygenase activity	Losses
DPSEU	GO:0005436	sodium:phosphate symporter activity	Losses
DPSEU	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
DPSEU	GO:0070410	co-SMAD binding	Losses
DPSEU	GO:0003867	4-aminobutyrate transaminase activity	Losses
DPSEU	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
DPSEU	GO:0042910	xenobiotic transmembrane transporter activity	Losses
DPSEU	GO:0022836	gated channel activity	Losses
DPSEU	GO:0005549	odorant binding	Losses
DPSEU	GO:0003993	acid phosphatase activity	Losses
DPSEU	GO:0016615	malate dehydrogenase activity	Losses
DPSEU	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
DPSEU	GO:0004705	JUN kinase activity	Extinctions
DPSEU	GO:0016909	SAP kinase activity	Extinctions
DPSEU	GO:0004707	MAP kinase activity	Extinctions
DPSEU	GO:0008061	chitin binding	Extinctions
DPSEU	GO:0003837	beta-ureidopropionase activity	Extinctions
DPSEU	GO:0047696	beta-adrenergic receptor kinase activity	Extinctions
DPSEU	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Extinctions
DPSEU	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
DPSEU	GO:0004014	adenosylmethionine decarboxylase activity	Extinctions
DPSEU	GO:0008420	CTD phosphatase activity	Extinctions
DPSEU	GO:0003867	4-aminobutyrate transaminase activity	Extinctions
DPSEU	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
DPSEU	GO:0008026	ATP-dependent helicase activity	Extinctions
DPSEU	GO:0070035	purine NTP-dependent helicase activity	Extinctions
DPSEU	GO:0016992	lipoate synthase activity	Extinctions
DPSEU	GO:0070283	radical SAM enzyme activity	Extinctions
DPSEU	GO:0016979	lipoate-protein ligase activity	Extinctions
DPSEU	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Extinctions
DPSEU	GO:0046923	ER retention sequence binding	Extinctions
DPSEU	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	Extinctions
DPSEU	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Extinctions
DPSEU	GO:0000702	oxidized base lesion DNA N-glycosylase activity	Extinctions
DPSEU	GO:0061731	ribonucleoside-diphosphate reductase activity	Extinctions
DPSEU	GO:0030331	estrogen receptor binding	Extinctions
DPSEU	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Extinctions
DPSEU	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Extinctions
DPSEU	GO:0004478	methionine adenosyltransferase activity	Extinctions
DPSEU	GO:0004446	inositol-hexakisphosphate phosphatase activity	Extinctions
DPSEU	GO:0004806	triglyceride lipase activity	Extinctions
DPSEU	GO:0005057	signal transducer activity, downstream of receptor	Extinctions
DPSEU	GO:0008301	DNA binding, bending	Extinctions
DPSEU	GO:0019104	DNA N-glycosylase activity	Extinctions
DPSEU	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Extinctions
DPSEU	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
DPSEU	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Extinctions
DPSEU	GO:0004035	alkaline phosphatase activity	Extinctions
DPSEU	GO:0005549	odorant binding	Extinctions
HY13	GO:0005549	odorant binding	Gains
HY13	GO:0004984	olfactory receptor activity	Gains
HY13	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
HY13	GO:0004344	glucose dehydrogenase activity	Gains
HY13	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Gains
HY13	GO:0008812	choline dehydrogenase activity	Gains
HY13	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
HY13	GO:0009922	fatty acid elongase activity	Gains
HY13	GO:0004312	fatty acid synthase activity	Gains
HY13	GO:0005214	structural constituent of chitin-based cuticle	Gains
HY13	GO:0004888	transmembrane signaling receptor activity	Gains
HY13	GO:0008527	taste receptor activity	Gains
HY13	GO:0004930	G-protein coupled receptor activity	Gains
HY13	GO:0004521	endoribonuclease activity	Gains
HY13	GO:0099600	transmembrane receptor activity	Gains
HY13	GO:0038023	signaling receptor activity	Gains
HY13	GO:0042302	structural constituent of cuticle	Gains
HY13	GO:0004540	ribonuclease activity	Gains
HY13	GO:0030414	peptidase inhibitor activity	Gains
HY13	GO:0004796	thromboxane-A synthase activity	Gains
HY13	GO:0004734	pyrimidodiazepine synthase activity	Gains
HY13	GO:0050093	methanol dehydrogenase activity	Gains
HY13	GO:0015204	urea transmembrane transporter activity	Gains
HY13	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
HY13	GO:0033897	ribonuclease T2 activity	Gains
HY13	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Gains
HY13	GO:0004329	formate-tetrahydrofolate ligase activity	Gains
HY13	GO:0042301	phosphate ion binding	Gains
HY13	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
HY13	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Gains
HY13	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Gains
HY13	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
HY13	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Gains
HY13	GO:0060089	molecular transducer activity	Gains
HY13	GO:0016860	intramolecular oxidoreductase activity	Gains
HY13	GO:0061134	peptidase regulator activity	Gains
HY13	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HY13	GO:0004519	endonuclease activity	Gains
HY13	GO:0004872	receptor activity	Gains
HY13	GO:0005198	structural molecule activity	Gains
HY13	GO:0019788	NEDD8 transferase activity	Gains
HY13	GO:0004594	pantothenate kinase activity	Gains
HY13	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
HY13	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HY13	GO:0018685	alkane 1-monooxygenase activity	Gains
HY13	GO:0043874	acireductone synthase activity	Gains
HY13	GO:0046423	allene-oxide cyclase activity	Gains
HY13	GO:0005199	structural constituent of cell wall	Gains
HY13	GO:0015037	peptide disulfide oxidoreductase activity	Gains
HY13	GO:0015038	glutathione disulfide oxidoreductase activity	Gains
HY13	GO:0005212	structural constituent of eye lens	Gains
HY13	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Gains
HY13	GO:0050591	quinine 3-monooxygenase activity	Gains
HY13	GO:0050660	flavin adenine dinucleotide binding	Gains
HY13	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Gains
HY13	GO:0004857	enzyme inhibitor activity	Gains
HY13	GO:0004871	signal transducer activity	Gains
HY13	GO:0004197	cysteine-type endopeptidase activity	Gains
HY13	GO:0015439	heme-transporting ATPase activity	Gains
HY13	GO:0000213	tRNA-intron endonuclease activity	Gains
HY13	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
HY13	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
HY13	GO:0048244	phytanoyl-CoA dioxygenase activity	Gains
HY13	GO:0004090	carbonyl reductase (NADPH) activity	Gains
HY13	GO:0016286	small conductance calcium-activated potassium channel activity	Gains
HY13	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY13	GO:0034061	DNA polymerase activity	Losses
HY13	GO:0022843	voltage-gated cation channel activity	Losses
HY13	GO:0070001	aspartic-type peptidase activity	Losses
HY13	GO:0004190	aspartic-type endopeptidase activity	Losses
HY13	GO:0022832	voltage-gated channel activity	Losses
HY13	GO:0005244	voltage-gated ion channel activity	Losses
HY13	GO:0005249	voltage-gated potassium channel activity	Losses
HY13	GO:0022836	gated channel activity	Losses
HY13	GO:0140097	catalytic activity, acting on DNA	Losses
HY13	GO:0016779	nucleotidyltransferase activity	Losses
HY13	GO:0005267	potassium channel activity	Losses
HY13	GO:0015079	potassium ion transmembrane transporter activity	Losses
HY13	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
HY13	GO:0052870	tocopherol omega-hydroxylase activity	Losses
HY13	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
HY13	GO:0018445	prothoracicotrophic hormone activity	Losses
HY13	GO:0001784	phosphotyrosine residue binding	Losses
HY13	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
HY13	GO:0045309	protein phosphorylated amino acid binding	Losses
HY13	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
HY13	GO:0004097	catechol oxidase activity	Losses
HY13	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
HY13	GO:0036263	L-DOPA monooxygenase activity	Losses
HY13	GO:0036264	dopamine monooxygenase activity	Losses
HY13	GO:0005122	torso binding	Losses
HY13	GO:0004321	fatty-acyl-CoA synthase activity	Losses
HY13	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
HY13	GO:0005222	intracellular cAMP activated cation channel activity	Losses
HY13	GO:0005223	intracellular cGMP activated cation channel activity	Losses
HY13	GO:0005261	cation channel activity	Losses
HY13	GO:0004497	monooxygenase activity	Losses
HY13	GO:0005216	ion channel activity	Losses
HY13	GO:0022838	substrate-specific channel activity	Losses
HY13	GO:0003676	nucleic acid binding	Losses
HY13	GO:0022803	passive transmembrane transporter activity	Losses
HY13	GO:0015267	channel activity	Losses
HY13	GO:0005102	receptor binding	Losses
HY13	GO:1990782	protein tyrosine kinase binding	Losses
HY13	GO:0004102	choline O-acetyltransferase activity	Losses
HY13	GO:0030553	cGMP binding	Losses
HY13	GO:0004503	monophenol monooxygenase activity	Losses
HY13	GO:0033883	pyridoxal phosphatase activity	Losses
HY13	GO:0030971	receptor tyrosine kinase binding	Losses
HY13	GO:0018685	alkane 1-monooxygenase activity	Losses
HY13	GO:0008332	low voltage-gated calcium channel activity	Losses
HY13	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Losses
HY13	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
HY13	GO:0019901	protein kinase binding	Losses
HY13	GO:0003677	DNA binding	Losses
HY13	GO:0016413	O-acetyltransferase activity	Losses
HY13	GO:0048244	phytanoyl-CoA dioxygenase activity	Losses
HY13	GO:0051219	phosphoprotein binding	Losses
HY13	GO:0004035	alkaline phosphatase activity	Losses
HY13	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
HY13	GO:0019900	kinase binding	Losses
HY13	GO:0030551	cyclic nucleotide binding	Losses
HY13	GO:0004692	cGMP-dependent protein kinase activity	Losses
HY13	GO:0045289	luciferin monooxygenase activity	Losses
HY13	GO:0005217	intracellular ligand-gated ion channel activity	Losses
HY13	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
HY13	GO:0003700	DNA binding transcription factor activity	Losses
HY13	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY13	GO:0034061	DNA polymerase activity	Extinctions
HY13	GO:0070001	aspartic-type peptidase activity	Extinctions
HY13	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY13	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY13	GO:0016779	nucleotidyltransferase activity	Extinctions
HY13	GO:0018445	prothoracicotrophic hormone activity	Extinctions
HY13	GO:0005122	torso binding	Extinctions
HY13	GO:0005102	receptor binding	Extinctions
HY13	GO:0004102	choline O-acetyltransferase activity	Extinctions
HY13	GO:0016413	O-acetyltransferase activity	Extinctions
HY13	GO:0048244	phytanoyl-CoA dioxygenase activity	Extinctions
HY13	GO:0004035	alkaline phosphatase activity	Extinctions
HY13	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
HY13	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
HY13	GO:0005154	epidermal growth factor receptor binding	Extinctions
HY13	GO:0008233	peptidase activity	Extinctions
HY13	GO:0016740	transferase activity	Extinctions
HY13	GO:0070851	growth factor receptor binding	Extinctions
HY13	GO:0004935	adrenergic receptor activity	Extinctions
HY13	GO:0003723	RNA binding	Extinctions
HY13	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
HY13	GO:0005326	neurotransmitter transporter activity	Extinctions
DNOVA	GO:0009055	electron transfer activity	Gains
DNOVA	GO:0004984	olfactory receptor activity	Gains
DNOVA	GO:0005549	odorant binding	Gains
DNOVA	GO:0051540	metal cluster binding	Gains
DNOVA	GO:0051536	iron-sulfur cluster binding	Gains
DNOVA	GO:0003954	NADH dehydrogenase activity	Gains
DNOVA	GO:0003964	RNA-directed DNA polymerase activity	Gains
DNOVA	GO:0004812	aminoacyl-tRNA ligase activity	Gains
DNOVA	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Gains
DNOVA	GO:0050136	NADH dehydrogenase (quinone) activity	Gains
DNOVA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DNOVA	GO:0004518	nuclease activity	Gains
DNOVA	GO:0051539	4 iron, 4 sulfur cluster binding	Gains
DNOVA	GO:0140101	catalytic activity, acting on a tRNA	Gains
DNOVA	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
DNOVA	GO:0016491	oxidoreductase activity	Gains
DNOVA	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
DNOVA	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
DNOVA	GO:0004519	endonuclease activity	Gains
DNOVA	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
DNOVA	GO:0003824	catalytic activity	Gains
DNOVA	GO:1901363	heterocyclic compound binding	Gains
DNOVA	GO:0140097	catalytic activity, acting on DNA	Gains
DNOVA	GO:0034061	DNA polymerase activity	Gains
DNOVA	GO:0097159	organic cyclic compound binding	Gains
DNOVA	GO:0004658	propionyl-CoA carboxylase activity	Gains
DNOVA	GO:0048038	quinone binding	Gains
DNOVA	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
DNOVA	GO:0048037	cofactor binding	Gains
DNOVA	GO:0032553	ribonucleotide binding	Gains
DNOVA	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
DNOVA	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Gains
DNOVA	GO:0004813	alanine-tRNA ligase activity	Gains
DNOVA	GO:0005184	neuropeptide hormone activity	Gains
DNOVA	GO:0051287	NAD binding	Gains
DNOVA	GO:0004930	G-protein coupled receptor activity	Gains
DNOVA	GO:0036094	small molecule binding	Gains
DNOVA	GO:0140098	catalytic activity, acting on RNA	Gains
DNOVA	GO:0017076	purine nucleotide binding	Gains
DNOVA	GO:1901265	nucleoside phosphate binding	Gains
DNOVA	GO:0000166	nucleotide binding	Gains
DNOVA	GO:0002161	aminoacyl-tRNA editing activity	Gains
DNOVA	GO:0030554	adenyl nucleotide binding	Gains
DNOVA	GO:0005179	hormone activity	Gains
DNOVA	GO:0097367	carbohydrate derivative binding	Gains
DNOVA	GO:0035639	purine ribonucleoside triphosphate binding	Gains
DNOVA	GO:0043168	anion binding	Gains
DNOVA	GO:0032555	purine ribonucleotide binding	Gains
DNOVA	GO:0005524	ATP binding	Gains
DNOVA	GO:0032559	adenyl ribonucleotide binding	Gains
DNOVA	GO:0016801	hydrolase activity, acting on ether bonds	Gains
DNOVA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
DNOVA	GO:0038023	signaling receptor activity	Gains
DNOVA	GO:0004104	cholinesterase activity	Gains
DNOVA	GO:0003990	acetylcholinesterase activity	Gains
DNOVA	GO:0004888	transmembrane signaling receptor activity	Gains
DNOVA	GO:0005009	insulin-activated receptor activity	Gains
DNOVA	GO:0008908	isochorismatase activity	Gains
DNOVA	GO:0097108	hedgehog family protein binding	Gains
DNOVA	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Gains
DNOVA	GO:0043334	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Gains
DNOVA	GO:0004997	thyrotropin-releasing hormone receptor activity	Gains
DNOVA	GO:0031071	cysteine desulfurase activity	Gains
DNOVA	GO:0005436	sodium:phosphate symporter activity	Gains
DNOVA	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Gains
DNOVA	GO:0016084	myostimulatory hormone activity	Gains
DNOVA	GO:0042654	ecdysis-triggering hormone receptor activity	Gains
DNOVA	GO:0004324	ferredoxin-NADP+ reductase activity	Gains
DNOVA	GO:0000990	transcription factor activity, core RNA polymerase binding	Gains
DNOVA	GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity	Gains
DNOVA	GO:0016987	sigma factor activity	Gains
DNOVA	GO:0051425	PTB domain binding	Gains
DNOVA	GO:0003838	sterol 24-C-methyltransferase activity	Gains
DNOVA	GO:0033867	Fas-activated serine/threonine kinase activity	Gains
DNOVA	GO:0008836	diaminopimelate decarboxylase activity	Gains
DNOVA	GO:0043560	insulin receptor substrate binding	Gains
DNOVA	GO:0043559	insulin binding	Gains
DNOVA	GO:0042954	lipoprotein transporter activity	Gains
DNOVA	GO:0004793	threonine aldolase activity	Gains
DNOVA	GO:0004796	thromboxane-A synthase activity	Gains
DNOVA	GO:0005550	pheromone binding	Gains
DNOVA	GO:0030350	iron-responsive element binding	Gains
DNOVA	GO:0008681	2-octaprenyl-6-methoxyphenol hydroxylase activity	Gains
DNOVA	GO:0004586	ornithine decarboxylase activity	Gains
DNOVA	GO:0008974	phosphoribulokinase activity	Gains
DNOVA	GO:0000155	phosphorelay sensor kinase activity	Gains
DNOVA	GO:0004673	protein histidine kinase activity	Gains
DNOVA	GO:0070279	vitamin B6 binding	Gains
DNOVA	GO:0030170	pyridoxal phosphate binding	Gains
DNOVA	GO:0043022	ribosome binding	Gains
DNOVA	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
DNOVA	GO:0034061	DNA polymerase activity	Losses
DNOVA	GO:0003964	RNA-directed DNA polymerase activity	Losses
DNOVA	GO:0016779	nucleotidyltransferase activity	Losses
DNOVA	GO:0140097	catalytic activity, acting on DNA	Losses
DNOVA	GO:0070001	aspartic-type peptidase activity	Losses
DNOVA	GO:0004190	aspartic-type endopeptidase activity	Losses
DNOVA	GO:0004872	receptor activity	Losses
DNOVA	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
DNOVA	GO:0060089	molecular transducer activity	Losses
DNOVA	GO:0008233	peptidase activity	Losses
DNOVA	GO:0004930	G-protein coupled receptor activity	Losses
DNOVA	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
DNOVA	GO:0038024	cargo receptor activity	Losses
DNOVA	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
DNOVA	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
DNOVA	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
DNOVA	GO:0042302	structural constituent of cuticle	Losses
DNOVA	GO:0099600	transmembrane receptor activity	Losses
DNOVA	GO:0005214	structural constituent of chitin-based cuticle	Losses
DNOVA	GO:0001871	pattern binding	Losses
DNOVA	GO:0030247	polysaccharide binding	Losses
DNOVA	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
DNOVA	GO:0004888	transmembrane signaling receptor activity	Losses
DNOVA	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
DNOVA	GO:0004629	phospholipase C activity	Losses
DNOVA	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
DNOVA	GO:0003677	DNA binding	Losses
DNOVA	GO:0005044	scavenger receptor activity	Losses
DNOVA	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
DNOVA	GO:0003676	nucleic acid binding	Losses
DNOVA	GO:0004871	signal transducer activity	Losses
DNOVA	GO:0038023	signaling receptor activity	Losses
DNOVA	GO:0003723	RNA binding	Losses
DNOVA	GO:0030246	carbohydrate binding	Losses
DNOVA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DNOVA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DNOVA	GO:0050839	cell adhesion molecule binding	Losses
DNOVA	GO:0004984	olfactory receptor activity	Losses
DNOVA	GO:0022843	voltage-gated cation channel activity	Losses
DNOVA	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
DNOVA	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
DNOVA	GO:0004993	G-protein coupled serotonin receptor activity	Losses
DNOVA	GO:0099589	serotonin receptor activity	Losses
DNOVA	GO:0008013	beta-catenin binding	Losses
DNOVA	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
DNOVA	GO:0004175	endopeptidase activity	Losses
DNOVA	GO:0003713	transcription coactivator activity	Losses
DNOVA	GO:0005200	structural constituent of cytoskeleton	Losses
DNOVA	GO:1901682	sulfur compound transmembrane transporter activity	Losses
DNOVA	GO:0005245	voltage-gated calcium channel activity	Losses
DNOVA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
DNOVA	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
DNOVA	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
DNOVA	GO:0035013	myosuppressin receptor activity	Losses
DNOVA	GO:0017159	pantetheine hydrolase activity	Losses
DNOVA	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
DNOVA	GO:0004055	argininosuccinate synthase activity	Losses
DNOVA	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Losses
DNOVA	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
DNOVA	GO:0004994	somatostatin receptor activity	Losses
DNOVA	GO:0004985	opioid receptor activity	Losses
DNOVA	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
DNOVA	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
DNOVA	GO:0047886	farnesol dehydrogenase activity	Losses
DNOVA	GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	Losses
DNOVA	GO:0032542	sulfiredoxin activity	Losses
DNOVA	GO:0004398	histidine decarboxylase activity	Losses
DNOVA	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
DNOVA	GO:0004321	fatty-acyl-CoA synthase activity	Losses
DNOVA	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	Losses
DNOVA	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
DNOVA	GO:0045118	azole transporter activity	Losses
DNOVA	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
DNOVA	GO:0005222	intracellular cAMP activated cation channel activity	Losses
DNOVA	GO:0005223	intracellular cGMP activated cation channel activity	Losses
DNOVA	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
DNOVA	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
DNOVA	GO:1901474	azole transmembrane transporter activity	Losses
DNOVA	GO:0051183	vitamin transporter activity	Losses
DNOVA	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
DNOVA	GO:0033819	lipoyl(octanoyl) transferase activity	Losses
DNOVA	GO:0015234	thiamine transmembrane transporter activity	Losses
DNOVA	GO:0042947	glucoside transmembrane transporter activity	Losses
DNOVA	GO:0090482	vitamin transmembrane transporter activity	Losses
DNOVA	GO:0001222	transcription corepressor binding	Losses
DNOVA	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
DNOVA	GO:0090422	thiamine pyrophosphate transporter activity	Losses
DNOVA	GO:0016415	octanoyltransferase activity	Losses
DNOVA	GO:0036132	13-prostaglandin reductase activity	Losses
DNOVA	GO:0015574	trehalose transmembrane transporter activity	Losses
DNOVA	GO:0010461	light-activated ion channel activity	Losses
DNOVA	GO:0035650	AP-1 adaptor complex binding	Losses
DNOVA	GO:0097493	structural molecule activity conferring elasticity	Losses
DNOVA	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
DNOVA	GO:0015619	thiamine pyrophosphate-transporting ATPase activity	Losses
DNOVA	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
DNOVA	GO:0005041	low-density lipoprotein receptor activity	Losses
DNOVA	GO:0008061	chitin binding	Losses
DNOVA	GO:0003887	DNA-directed DNA polymerase activity	Losses
DNOVA	GO:0005198	structural molecule activity	Losses
DNOVA	GO:0022832	voltage-gated channel activity	Losses
DNOVA	GO:0005244	voltage-gated ion channel activity	Losses
DNOVA	GO:0016405	CoA-ligase activity	Losses
DNOVA	GO:0034061	DNA polymerase activity	Extinctions
DNOVA	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DNOVA	GO:0003713	transcription coactivator activity	Extinctions
DNOVA	GO:0016779	nucleotidyltransferase activity	Extinctions
DNOVA	GO:0070001	aspartic-type peptidase activity	Extinctions
DNOVA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
DNOVA	GO:0038024	cargo receptor activity	Extinctions
DNOVA	GO:0004435	phosphatidylinositol phospholipase C activity	Extinctions
DNOVA	GO:0004629	phospholipase C activity	Extinctions
DNOVA	GO:0017159	pantetheine hydrolase activity	Extinctions
DNOVA	GO:0004055	argininosuccinate synthase activity	Extinctions
DNOVA	GO:0004994	somatostatin receptor activity	Extinctions
DNOVA	GO:0004985	opioid receptor activity	Extinctions
DNOVA	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
DNOVA	GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	Extinctions
DNOVA	GO:0032542	sulfiredoxin activity	Extinctions
DNOVA	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
DNOVA	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	Extinctions
DNOVA	GO:0045118	azole transporter activity	Extinctions
DNOVA	GO:1901474	azole transmembrane transporter activity	Extinctions
DNOVA	GO:0051183	vitamin transporter activity	Extinctions
DNOVA	GO:0015234	thiamine transmembrane transporter activity	Extinctions
DNOVA	GO:0090482	vitamin transmembrane transporter activity	Extinctions
DNOVA	GO:0090422	thiamine pyrophosphate transporter activity	Extinctions
DNOVA	GO:0036132	13-prostaglandin reductase activity	Extinctions
DNOVA	GO:0035650	AP-1 adaptor complex binding	Extinctions
DNOVA	GO:0015619	thiamine pyrophosphate-transporting ATPase activity	Extinctions
DNOVA	GO:0005041	low-density lipoprotein receptor activity	Extinctions
DNOVA	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
DNOVA	GO:0016859	cis-trans isomerase activity	Extinctions
DNOVA	GO:0140097	catalytic activity, acting on DNA	Extinctions
DNOVA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
59	GO:0020037	heme binding	Gains
59	GO:0046906	tetrapyrrole binding	Gains
59	GO:0050660	flavin adenine dinucleotide binding	Gains
59	GO:0009055	electron transfer activity	Gains
59	GO:0050662	coenzyme binding	Gains
59	GO:0051213	dioxygenase activity	Gains
59	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
59	GO:0016783	sulfurtransferase activity	Gains
59	GO:0048037	cofactor binding	Gains
59	GO:0003995	acyl-CoA dehydrogenase activity	Gains
59	GO:0004930	G-protein coupled receptor activity	Gains
59	GO:0003991	acetylglutamate kinase activity	Gains
59	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Gains
59	GO:0031071	cysteine desulfurase activity	Gains
59	GO:0004060	arylamine N-acetyltransferase activity	Gains
59	GO:0004059	aralkylamine N-acetyltransferase activity	Gains
59	GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Gains
59	GO:0030366	molybdopterin synthase activity	Gains
59	GO:0043914	NADPH:sulfur oxidoreductase activity	Gains
59	GO:0072320	volume-sensitive chloride channel activity	Gains
59	GO:0004362	glutathione-disulfide reductase activity	Gains
59	GO:0004339	glucan 1,4-alpha-glucosidase activity	Gains
59	GO:0042767	ecdysteroid 22-hydroxylase activity	Gains
59	GO:0008781	N-acylneuraminate cytidylyltransferase activity	Gains
59	GO:0005225	volume-sensitive anion channel activity	Gains
59	GO:0008811	chloramphenicol O-acetyltransferase activity	Gains
59	GO:0004791	thioredoxin-disulfide reductase activity	Gains
59	GO:0050661	NADP binding	Gains
59	GO:0046873	metal ion transmembrane transporter activity	Gains
59	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
59	GO:0016491	oxidoreductase activity	Gains
59	GO:0022890	inorganic cation transmembrane transporter activity	Gains
59	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	Gains
59	GO:0004833	tryptophan 2,3-dioxygenase activity	Gains
59	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
59	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Gains
59	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	Gains
59	GO:0004501	ecdysone 20-monooxygenase activity	Gains
59	GO:0003945	N-acetyllactosamine synthase activity	Gains
59	GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	Gains
59	GO:0045505	dynein intermediate chain binding	Gains
59	GO:0043958	acryloyl-CoA reductase activity	Gains
59	GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
59	GO:0008475	procollagen-lysine 5-dioxygenase activity	Gains
59	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
59	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
59	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
59	GO:0005391	sodium:potassium-exchanging ATPase activity	Gains
59	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
59	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
59	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
59	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
59	GO:0004345	glucose-6-phosphate dehydrogenase activity	Gains
59	GO:0004335	galactokinase activity	Gains
59	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
59	GO:0015037	peptide disulfide oxidoreductase activity	Gains
59	GO:0015038	glutathione disulfide oxidoreductase activity	Gains
59	GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	Gains
59	GO:0005200	structural constituent of cytoskeleton	Gains
59	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
59	GO:0015926	glucosidase activity	Losses
59	GO:0032450	maltose alpha-glucosidase activity	Losses
59	GO:0090599	alpha-glucosidase activity	Losses
59	GO:0042834	peptidoglycan binding	Losses
59	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
59	GO:0005212	structural constituent of eye lens	Losses
59	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
59	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
59	GO:0003964	RNA-directed DNA polymerase activity	Losses
59	GO:0022857	transmembrane transporter activity	Losses
59	GO:0005215	transporter activity	Losses
59	GO:0008233	peptidase activity	Losses
59	GO:0008613	diuretic hormone activity	Losses
59	GO:0005000	vasopressin receptor activity	Losses
59	GO:0099600	transmembrane receptor activity	Losses
59	GO:0004181	metallocarboxypeptidase activity	Losses
59	GO:0061783	peptidoglycan muralytic activity	Losses
59	GO:0034061	DNA polymerase activity	Losses
59	GO:0008528	G-protein coupled peptide receptor activity	Losses
59	GO:0001653	peptide receptor activity	Losses
59	GO:0050254	rhodopsin kinase activity	Losses
59	GO:0004180	carboxypeptidase activity	Losses
59	GO:0005184	neuropeptide hormone activity	Losses
59	GO:0004888	transmembrane signaling receptor activity	Losses
59	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
59	GO:0004871	signal transducer activity	Losses
59	GO:0004872	receptor activity	Losses
59	GO:0005179	hormone activity	Losses
59	GO:0038023	signaling receptor activity	Losses
59	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
59	GO:0005509	calcium ion binding	Losses
59	GO:0060089	molecular transducer activity	Losses
59	GO:0008237	metallopeptidase activity	Losses
59	GO:0005539	glycosaminoglycan binding	Losses
59	GO:0046914	transition metal ion binding	Losses
59	GO:0001664	G-protein coupled receptor binding	Losses
59	GO:0008235	metalloexopeptidase activity	Losses
59	GO:0004930	G-protein coupled receptor activity	Losses
59	GO:0004175	endopeptidase activity	Losses
59	GO:0005549	odorant binding	Losses
59	GO:0048018	receptor ligand activity	Losses
59	GO:0016779	nucleotidyltransferase activity	Losses
59	GO:0005230	extracellular ligand-gated ion channel activity	Losses
59	GO:0061778	intracellular chloride channel activity	Losses
59	GO:0031544	peptidyl-proline 3-dioxygenase activity	Losses
59	GO:0004846	urate oxidase activity	Losses
59	GO:0016019	peptidoglycan receptor activity	Losses
59	GO:0001875	lipopolysaccharide receptor activity	Losses
59	GO:0015438	teichoic-acid-transporting ATPase activity	Losses
59	GO:0019797	procollagen-proline 3-dioxygenase activity	Losses
59	GO:0015162	teichoic acid transmembrane transporter activity	Losses
59	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
59	GO:0032813	tumor necrosis factor receptor superfamily binding	Losses
59	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
59	GO:0001586	Gi/o-coupled serotonin receptor activity	Losses
59	GO:0015142	tricarboxylic acid transmembrane transporter activity	Losses
59	GO:0015137	citrate transmembrane transporter activity	Losses
59	GO:0042943	D-amino acid transmembrane transporter activity	Losses
59	GO:0042947	glucoside transmembrane transporter activity	Losses
59	GO:0008940	nitrate reductase activity	Losses
59	GO:0015222	serotonin transmembrane transporter activity	Losses
59	GO:0019811	cocaine binding	Losses
59	GO:0032500	muramyl dipeptide binding	Losses
59	GO:0045735	nutrient reservoir activity	Losses
59	GO:0004061	arylformamidase activity	Losses
59	GO:0050700	CARD domain binding	Losses
59	GO:0004971	AMPA glutamate receptor activity	Losses
59	GO:0004946	bombesin receptor activity	Losses
59	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
59	GO:0015574	trehalose transmembrane transporter activity	Losses
59	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
59	GO:0008191	metalloendopeptidase inhibitor activity	Losses
59	GO:0005329	dopamine transmembrane transporter activity	Losses
59	GO:0052729	dimethylglycine N-methyltransferase activity	Losses
59	GO:0052730	sarcosine N-methyltransferase activity	Losses
59	GO:0004321	fatty-acyl-CoA synthase activity	Losses
59	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
59	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
59	GO:0005164	tumor necrosis factor receptor binding	Losses
59	GO:0009703	nitrate reductase (NADH) activity	Losses
59	GO:0017174	glycine N-methyltransferase activity	Losses
59	GO:0005229	intracellular calcium activated chloride channel activity	Losses
59	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Losses
59	GO:0004760	serine-pyruvate transaminase activity	Losses
59	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
59	GO:0030545	receptor regulator activity	Losses
59	GO:0022891	substrate-specific transmembrane transporter activity	Losses
59	GO:0004497	monooxygenase activity	Losses
59	GO:0016491	oxidoreductase activity	Losses
59	GO:0004568	chitinase activity	Losses
59	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
59	GO:0004984	olfactory receptor activity	Losses
59	GO:0022892	substrate-specific transporter activity	Losses
59	GO:0015276	ligand-gated ion channel activity	Losses
59	GO:0022834	ligand-gated channel activity	Losses
59	GO:0043169	cation binding	Losses
59	GO:0046943	carboxylic acid transmembrane transporter activity	Losses
59	GO:0005342	organic acid transmembrane transporter activity	Losses
59	GO:0004970	ionotropic glutamate receptor activity	Novel expansions
59	GO:0022824	transmitter-gated ion channel activity	Novel expansions
59	GO:0022835	transmitter-gated channel activity	Novel expansions
59	GO:0005234	extracellularly glutamate-gated ion channel activity	Novel expansions
59	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Novel expansions
59	GO:0008066	glutamate receptor activity	Novel expansions
59	GO:0030594	neurotransmitter receptor activity	Novel expansions
59	GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
59	GO:0015276	ligand-gated ion channel activity	Novel expansions
59	GO:0022834	ligand-gated channel activity	Novel expansions
59	GO:0022836	gated channel activity	Novel expansions
59	GO:0004842	ubiquitin-protein transferase activity	Novel expansions
59	GO:0019787	ubiquitin-like protein transferase activity	Novel expansions
59	GO:0005216	ion channel activity	Novel expansions
59	GO:0022838	substrate-specific channel activity	Novel expansions
59	GO:0015267	channel activity	Novel expansions
59	GO:0022803	passive transmembrane transporter activity	Novel expansions
59	GO:0008613	diuretic hormone activity	Extinctions
59	GO:0005184	neuropeptide hormone activity	Extinctions
59	GO:0005179	hormone activity	Extinctions
59	GO:0001664	G-protein coupled receptor binding	Extinctions
59	GO:0032450	maltose alpha-glucosidase activity	Extinctions
59	GO:0048018	receptor ligand activity	Extinctions
59	GO:0090599	alpha-glucosidase activity	Extinctions
59	GO:0030545	receptor regulator activity	Extinctions
59	GO:0005506	iron ion binding	Extinctions
59	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
59	GO:0034061	DNA polymerase activity	Extinctions
59	GO:0005509	calcium ion binding	Extinctions
59	GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
59	GO:0004846	urate oxidase activity	Extinctions
59	GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
59	GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
59	GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
59	GO:0032813	tumor necrosis factor receptor superfamily binding	Extinctions
59	GO:0004061	arylformamidase activity	Extinctions
59	GO:0050700	CARD domain binding	Extinctions
59	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
59	GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
59	GO:0052729	dimethylglycine N-methyltransferase activity	Extinctions
59	GO:0052730	sarcosine N-methyltransferase activity	Extinctions
59	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
59	GO:0005164	tumor necrosis factor receptor binding	Extinctions
59	GO:0017174	glycine N-methyltransferase activity	Extinctions
59	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
59	GO:0004760	serine-pyruvate transaminase activity	Extinctions
59	GO:0015926	glucosidase activity	Extinctions
59	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Extinctions
59	GO:0070001	aspartic-type peptidase activity	Extinctions
59	GO:0004190	aspartic-type endopeptidase activity	Extinctions
59	GO:0004175	endopeptidase activity	Extinctions
59	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Extinctions
59	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Extinctions
59	GO:0051537	2 iron, 2 sulfur cluster binding	Extinctions
59	GO:0016779	nucleotidyltransferase activity	Extinctions
58	GO:0003964	RNA-directed DNA polymerase activity	Gains
58	GO:0140097	catalytic activity, acting on DNA	Gains
58	GO:0034061	DNA polymerase activity	Gains
58	GO:0016779	nucleotidyltransferase activity	Gains
58	GO:0004190	aspartic-type endopeptidase activity	Gains
58	GO:0070001	aspartic-type peptidase activity	Gains
58	GO:0004175	endopeptidase activity	Gains
58	GO:0097159	organic cyclic compound binding	Gains
58	GO:1901363	heterocyclic compound binding	Gains
58	GO:0003678	DNA helicase activity	Gains
58	GO:0003676	nucleic acid binding	Gains
58	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
58	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
58	GO:0000156	phosphorelay response regulator activity	Gains
58	GO:0008233	peptidase activity	Gains
58	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
58	GO:0004518	nuclease activity	Gains
58	GO:0010181	FMN binding	Gains
58	GO:0046914	transition metal ion binding	Gains
58	GO:0008270	zinc ion binding	Gains
58	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
58	GO:0005215	transporter activity	Gains
58	GO:0048037	cofactor binding	Gains
58	GO:0005452	inorganic anion exchanger activity	Gains
58	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
58	GO:0022857	transmembrane transporter activity	Gains
58	GO:0004364	glutathione transferase activity	Gains
58	GO:0003960	NADPH:quinone reductase activity	Gains
58	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
58	GO:0015171	amino acid transmembrane transporter activity	Gains
58	GO:0008509	anion transmembrane transporter activity	Gains
58	GO:0004252	serine-type endopeptidase activity	Gains
58	GO:0042302	structural constituent of cuticle	Gains
58	GO:0015075	ion transmembrane transporter activity	Gains
58	GO:0004803	transposase activity	Gains
58	GO:0008236	serine-type peptidase activity	Gains
58	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
58	GO:0017171	serine hydrolase activity	Gains
58	GO:0004035	alkaline phosphatase activity	Gains
58	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
58	GO:0022892	substrate-specific transporter activity	Gains
58	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
58	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
58	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
58	GO:0005342	organic acid transmembrane transporter activity	Gains
58	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
58	GO:0016829	lyase activity	Gains
58	GO:0008514	organic anion transmembrane transporter activity	Gains
58	GO:0019842	vitamin binding	Gains
58	GO:0015269	calcium-activated potassium channel activity	Gains
58	GO:0022891	substrate-specific transmembrane transporter activity	Gains
58	GO:0004519	endonuclease activity	Gains
58	GO:0004386	helicase activity	Gains
58	GO:0070279	vitamin B6 binding	Gains
58	GO:0030170	pyridoxal phosphate binding	Gains
58	GO:0000155	phosphorelay sensor kinase activity	Gains
58	GO:0004673	protein histidine kinase activity	Gains
58	GO:0005227	calcium activated cation channel activity	Gains
58	GO:0022890	inorganic cation transmembrane transporter activity	Gains
58	GO:0004470	malic enzyme activity	Gains
58	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
58	GO:0004478	methionine adenosyltransferase activity	Gains
58	GO:0005248	voltage-gated sodium channel activity	Gains
58	GO:0004733	pyridoxamine-phosphate oxidase activity	Gains
58	GO:1905030	voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential	Gains
58	GO:0003913	DNA photolyase activity	Gains
58	GO:0003677	DNA binding	Gains
58	GO:0046873	metal ion transmembrane transporter activity	Gains
58	GO:0022836	gated channel activity	Gains
58	GO:0003824	catalytic activity	Gains
58	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
58	GO:0022839	ion gated channel activity	Gains
58	GO:0004872	receptor activity	Gains
58	GO:0016787	hydrolase activity	Gains
58	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
58	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
58	GO:0019201	nucleotide kinase activity	Gains
58	GO:0038023	signaling receptor activity	Gains
58	GO:0004871	signal transducer activity	Gains
58	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
58	GO:0004602	glutathione peroxidase activity	Gains
58	GO:0016917	GABA receptor activity	Gains
58	GO:0008324	cation transmembrane transporter activity	Gains
58	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
58	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Gains
58	GO:0043138	3'-5' DNA helicase activity	Gains
58	GO:0005416	cation:amino acid symporter activity	Losses
58	GO:0005283	sodium:amino acid symporter activity	Losses
58	GO:0005215	transporter activity	Losses
58	GO:0004970	ionotropic glutamate receptor activity	Losses
58	GO:0022824	transmitter-gated ion channel activity	Losses
58	GO:0022835	transmitter-gated channel activity	Losses
58	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
58	GO:0022857	transmembrane transporter activity	Losses
58	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
58	GO:0008066	glutamate receptor activity	Losses
58	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
58	GO:0020037	heme binding	Losses
58	GO:0005342	organic acid transmembrane transporter activity	Losses
58	GO:0046943	carboxylic acid transmembrane transporter activity	Losses
58	GO:0046906	tetrapyrrole binding	Losses
58	GO:0030594	neurotransmitter receptor activity	Losses
58	GO:0015179	L-amino acid transmembrane transporter activity	Losses
58	GO:0072341	modified amino acid binding	Losses
58	GO:0005343	organic acid:sodium symporter activity	Losses
58	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
58	GO:0008519	ammonium transmembrane transporter activity	Losses
58	GO:0022891	substrate-specific transmembrane transporter activity	Losses
58	GO:0030414	peptidase inhibitor activity	Losses
58	GO:0005044	scavenger receptor activity	Losses
58	GO:0008514	organic anion transmembrane transporter activity	Losses
58	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
58	GO:0070330	aromatase activity	Losses
58	GO:0004888	transmembrane signaling receptor activity	Losses
58	GO:0061134	peptidase regulator activity	Losses
58	GO:0015171	amino acid transmembrane transporter activity	Losses
58	GO:0038024	cargo receptor activity	Losses
58	GO:0005230	extracellular ligand-gated ion channel activity	Losses
58	GO:0008509	anion transmembrane transporter activity	Losses
58	GO:0022892	substrate-specific transporter activity	Losses
58	GO:0015293	symporter activity	Losses
58	GO:0015081	sodium ion transmembrane transporter activity	Losses
58	GO:0042943	D-amino acid transmembrane transporter activity	Losses
58	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Losses
58	GO:0004027	alcohol sulfotransferase activity	Losses
58	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
58	GO:0015250	water channel activity	Losses
58	GO:0015222	serotonin transmembrane transporter activity	Losses
58	GO:0019811	cocaine binding	Losses
58	GO:0015204	urea transmembrane transporter activity	Losses
58	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
58	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
58	GO:0052870	tocopherol omega-hydroxylase activity	Losses
58	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
58	GO:0000036	acyl carrier activity	Losses
58	GO:0005372	water transmembrane transporter activity	Losses
58	GO:0005329	dopamine transmembrane transporter activity	Losses
58	GO:0070513	death domain binding	Losses
58	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
58	GO:0004304	estrone sulfotransferase activity	Losses
58	GO:0044620	ACP phosphopantetheine attachment site binding	Losses
58	GO:0008226	tyramine receptor activity	Losses
58	GO:0008200	ion channel inhibitor activity	Losses
58	GO:0016248	channel inhibitor activity	Losses
58	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
58	GO:1900750	oligopeptide binding	Losses
58	GO:0009703	nitrate reductase (NADH) activity	Losses
58	GO:0031177	phosphopantetheine binding	Losses
58	GO:0004100	chitin synthase activity	Losses
58	GO:0008815	citrate (pro-3S)-lyase activity	Losses
58	GO:0008816	citryl-CoA lyase activity	Losses
58	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Losses
58	GO:0017151	DEAD/H-box RNA helicase binding	Losses
58	GO:0051192	prosthetic group binding	Losses
58	GO:0015054	gastrin receptor activity	Losses
58	GO:0001222	transcription corepressor binding	Losses
58	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
58	GO:0047749	cholestanetriol 26-monooxygenase activity	Losses
58	GO:0043295	glutathione binding	Losses
58	GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	Losses
58	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
58	GO:0004507	steroid 11-beta-monooxygenase activity	Losses
58	GO:0030544	Hsp70 protein binding	Losses
58	GO:0008940	nitrate reductase activity	Losses
58	GO:0004062	aryl sulfotransferase activity	Losses
58	GO:0004872	receptor activity	Losses
58	GO:0004857	enzyme inhibitor activity	Losses
58	GO:0030247	polysaccharide binding	Losses
58	GO:0001871	pattern binding	Losses
58	GO:0099600	transmembrane receptor activity	Losses
58	GO:0004984	olfactory receptor activity	Losses
58	GO:0015075	ion transmembrane transporter activity	Losses
58	GO:0015276	ligand-gated ion channel activity	Losses
58	GO:0022834	ligand-gated channel activity	Losses
58	GO:0022838	substrate-specific channel activity	Losses
58	GO:0060089	molecular transducer activity	Losses
58	GO:0038023	signaling receptor activity	Losses
58	GO:0005201	extracellular matrix structural constituent	Losses
58	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
58	GO:0015183	L-aspartate transmembrane transporter activity	Losses
58	GO:0031072	heat shock protein binding	Losses
58	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
58	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
58	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	Losses
58	GO:0018685	alkane 1-monooxygenase activity	Losses
58	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
58	GO:0015562	efflux transmembrane transporter activity	Losses
58	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Losses
58	GO:0015501	glutamate:sodium symporter activity	Losses
58	GO:0031127	alpha-(1,2)-fucosyltransferase activity	Losses
58	GO:0005212	structural constituent of eye lens	Losses
58	GO:0008504	monoamine transmembrane transporter activity	Losses
58	GO:0001221	transcription cofactor binding	Losses
58	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
58	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Losses
58	GO:0070405	ammonium ion binding	Losses
58	GO:0099106	ion channel regulator activity	Losses
58	GO:0050591	quinine 3-monooxygenase activity	Losses
58	GO:0015440	peptide-transporting ATPase activity	Losses
58	GO:0015267	channel activity	Losses
58	GO:0022803	passive transmembrane transporter activity	Losses
58	GO:0008194	UDP-glycosyltransferase activity	Losses
58	GO:0042887	amide transmembrane transporter activity	Losses
58	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
58	GO:0015370	solute:sodium symporter activity	Losses
58	GO:0008061	chitin binding	Novel expansions
58	GO:0072341	modified amino acid binding	Extinctions
58	GO:0004888	transmembrane signaling receptor activity	Extinctions
58	GO:0004970	ionotropic glutamate receptor activity	Extinctions
58	GO:0022824	transmitter-gated ion channel activity	Extinctions
58	GO:0022835	transmitter-gated channel activity	Extinctions
58	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
58	GO:0099600	transmembrane receptor activity	Extinctions
58	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
58	GO:0008066	glutamate receptor activity	Extinctions
58	GO:0038023	signaling receptor activity	Extinctions
58	GO:0004984	olfactory receptor activity	Extinctions
58	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
58	GO:0015204	urea transmembrane transporter activity	Extinctions
58	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
58	GO:0000036	acyl carrier activity	Extinctions
58	GO:0070513	death domain binding	Extinctions
58	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
58	GO:0008226	tyramine receptor activity	Extinctions
58	GO:0008200	ion channel inhibitor activity	Extinctions
58	GO:0016248	channel inhibitor activity	Extinctions
58	GO:1900750	oligopeptide binding	Extinctions
58	GO:0031177	phosphopantetheine binding	Extinctions
58	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
58	GO:0008816	citryl-CoA lyase activity	Extinctions
58	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Extinctions
58	GO:0051192	prosthetic group binding	Extinctions
58	GO:0015054	gastrin receptor activity	Extinctions
58	GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
58	GO:0043295	glutathione binding	Extinctions
58	GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	Extinctions
58	GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
58	GO:0030544	Hsp70 protein binding	Extinctions
58	GO:0030594	neurotransmitter receptor activity	Extinctions
58	GO:0004930	G-protein coupled receptor activity	Extinctions
58	GO:0030414	peptidase inhibitor activity	Extinctions
58	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Extinctions
58	GO:0042887	amide transmembrane transporter activity	Extinctions
58	GO:0061134	peptidase regulator activity	Extinctions
58	GO:0031072	heat shock protein binding	Extinctions
58	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
58	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	Extinctions
58	GO:0015562	efflux transmembrane transporter activity	Extinctions
58	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Extinctions
58	GO:0031127	alpha-(1,2)-fucosyltransferase activity	Extinctions
58	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Extinctions
58	GO:0099106	ion channel regulator activity	Extinctions
58	GO:0050591	quinine 3-monooxygenase activity	Extinctions
58	GO:0015440	peptide-transporting ATPase activity	Extinctions
58	GO:0020037	heme binding	Extinctions
58	GO:0046906	tetrapyrrole binding	Extinctions
58	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
58	GO:0033218	amide binding	Extinctions
58	GO:0022857	transmembrane transporter activity	Extinctions
58	GO:0004857	enzyme inhibitor activity	Extinctions
58	GO:0016833	oxo-acid-lyase activity	Extinctions
58	GO:0004630	phospholipase D activity	Extinctions
HY15	GO:0005549	odorant binding	Gains
HY15	GO:0004984	olfactory receptor activity	Gains
HY15	GO:0034061	DNA polymerase activity	Gains
HY15	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY15	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY15	GO:0140097	catalytic activity, acting on DNA	Gains
HY15	GO:0038023	signaling receptor activity	Gains
HY15	GO:0016779	nucleotidyltransferase activity	Gains
HY15	GO:0004872	receptor activity	Gains
HY15	GO:0099600	transmembrane receptor activity	Gains
HY15	GO:0004888	transmembrane signaling receptor activity	Gains
HY15	GO:0060089	molecular transducer activity	Gains
HY15	GO:0004930	G-protein coupled receptor activity	Gains
HY15	GO:0070001	aspartic-type peptidase activity	Gains
HY15	GO:0004190	aspartic-type endopeptidase activity	Gains
HY15	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
HY15	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
HY15	GO:0004871	signal transducer activity	Gains
HY15	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
HY15	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
HY15	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
HY15	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY15	GO:0004519	endonuclease activity	Gains
HY15	GO:0008233	peptidase activity	Gains
HY15	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY15	GO:0004175	endopeptidase activity	Gains
HY15	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY15	GO:0004521	endoribonuclease activity	Gains
HY15	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
HY15	GO:0015020	glucuronosyltransferase activity	Gains
HY15	GO:0005198	structural molecule activity	Gains
HY15	GO:0004866	endopeptidase inhibitor activity	Gains
HY15	GO:0000155	phosphorelay sensor kinase activity	Gains
HY15	GO:0004673	protein histidine kinase activity	Gains
HY15	GO:0004180	carboxypeptidase activity	Gains
HY15	GO:0061135	endopeptidase regulator activity	Gains
HY15	GO:0035250	UDP-galactosyltransferase activity	Gains
HY15	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
HY15	GO:0004181	metallocarboxypeptidase activity	Gains
HY15	GO:0019811	cocaine binding	Gains
HY15	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
HY15	GO:0004597	peptide-aspartate beta-dioxygenase activity	Gains
HY15	GO:0015222	serotonin transmembrane transporter activity	Gains
HY15	GO:0003938	IMP dehydrogenase activity	Gains
HY15	GO:0008919	lipopolysaccharide glucosyltransferase I activity	Gains
HY15	GO:0042577	lipid phosphatase activity	Gains
HY15	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Gains
HY15	GO:0005329	dopamine transmembrane transporter activity	Gains
HY15	GO:0036440	citrate synthase activity	Gains
HY15	GO:0042943	D-amino acid transmembrane transporter activity	Gains
HY15	GO:0008251	tRNA-specific adenosine deaminase activity	Gains
HY15	GO:0004398	histidine decarboxylase activity	Gains
HY15	GO:0032183	SUMO binding	Gains
HY15	GO:0004108	citrate (Si)-synthase activity	Gains
HY15	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HY15	GO:0003887	DNA-directed DNA polymerase activity	Gains
HY15	GO:0008378	galactosyltransferase activity	Gains
HY15	GO:0003723	RNA binding	Gains
HY15	GO:0004540	ribonuclease activity	Gains
HY15	GO:0030414	peptidase inhibitor activity	Gains
HY15	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
HY15	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
HY15	GO:0004837	tyrosine decarboxylase activity	Gains
HY15	GO:0003997	acyl-CoA oxidase activity	Gains
HY15	GO:0004555	alpha,alpha-trehalase activity	Gains
HY15	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
HY15	GO:0000702	oxidized base lesion DNA N-glycosylase activity	Gains
HY15	GO:1901618	organic hydroxy compound transmembrane transporter activity	Gains
HY15	GO:0030971	receptor tyrosine kinase binding	Gains
HY15	GO:1990782	protein tyrosine kinase binding	Gains
HY15	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
HY15	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
HY15	GO:0004033	aldo-keto reductase (NADP) activity	Gains
HY15	GO:0070405	ammonium ion binding	Gains
HY15	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
HY15	GO:0004371	glycerone kinase activity	Gains
HY15	GO:0050833	pyruvate transmembrane transporter activity	Gains
HY15	GO:0004470	malic enzyme activity	Gains
HY15	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
HY15	GO:0015927	trehalase activity	Gains
HY15	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	Gains
HY15	GO:0008504	monoamine transmembrane transporter activity	Gains
HY15	GO:0019788	NEDD8 transferase activity	Gains
HY15	GO:0061134	peptidase regulator activity	Gains
HY15	GO:0004022	alcohol dehydrogenase (NAD) activity	Losses
HY15	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
HY15	GO:0070330	aromatase activity	Losses
HY15	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
HY15	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
HY15	GO:0003730	mRNA 3'-UTR binding	Losses
HY15	GO:0038023	signaling receptor activity	Losses
HY15	GO:0004888	transmembrane signaling receptor activity	Losses
HY15	GO:0060089	molecular transducer activity	Losses
HY15	GO:0004857	enzyme inhibitor activity	Losses
HY15	GO:0099600	transmembrane receptor activity	Losses
HY15	GO:0004872	receptor activity	Losses
HY15	GO:0050093	methanol dehydrogenase activity	Losses
HY15	GO:0016018	cyclosporin A binding	Losses
HY15	GO:0032542	sulfiredoxin activity	Losses
HY15	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
HY15	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
HY15	GO:0016415	octanoyltransferase activity	Losses
HY15	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
HY15	GO:0033819	lipoyl(octanoyl) transferase activity	Losses
HY15	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
HY15	GO:0008426	protein kinase C inhibitor activity	Losses
HY15	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
HY15	GO:0015054	gastrin receptor activity	Losses
HY15	GO:0019113	limonene monooxygenase activity	Losses
HY15	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
HY15	GO:0042803	protein homodimerization activity	Losses
HY15	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
HY15	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
HY15	GO:0008227	G-protein coupled amine receptor activity	Losses
HY15	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
HY15	GO:0004930	G-protein coupled receptor activity	Losses
HY15	GO:0016491	oxidoreductase activity	Losses
HY15	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
HY15	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
HY15	GO:0004657	proline dehydrogenase activity	Losses
HY15	GO:0046975	histone methyltransferase activity (H3-K36 specific)	Losses
HY15	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
HY15	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	Losses
HY15	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	Losses
HY15	GO:0036122	BMP binding	Losses
HY15	GO:0034736	cholesterol O-acyltransferase activity	Losses
HY15	GO:0005212	structural constituent of eye lens	Losses
HY15	GO:0050824	water binding	Losses
HY15	GO:0050825	ice binding	Losses
HY15	GO:0004496	mevalonate kinase activity	Losses
HY15	GO:0050591	quinine 3-monooxygenase activity	Losses
HY15	GO:0004772	sterol O-acyltransferase activity	Losses
HY15	GO:0005509	calcium ion binding	Losses
HY15	GO:0005506	iron ion binding	Losses
HY15	GO:0005200	structural constituent of cytoskeleton	Losses
HY15	GO:0046983	protein dimerization activity	Losses
HY15	GO:0042802	identical protein binding	Losses
HY15	GO:0004857	enzyme inhibitor activity	Extinctions
HY15	GO:0038023	signaling receptor activity	Extinctions
HY15	GO:0016018	cyclosporin A binding	Extinctions
HY15	GO:0032542	sulfiredoxin activity	Extinctions
HY15	GO:0008426	protein kinase C inhibitor activity	Extinctions
HY15	GO:0015054	gastrin receptor activity	Extinctions
HY15	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY15	GO:0098772	molecular function regulator	Extinctions
HY15	GO:0099600	transmembrane receptor activity	Extinctions
HY15	GO:0030234	enzyme regulator activity	Extinctions
HY15	GO:0034061	DNA polymerase activity	Extinctions
HY15	GO:0004657	proline dehydrogenase activity	Extinctions
HY15	GO:0036122	BMP binding	Extinctions
HY15	GO:0034736	cholesterol O-acyltransferase activity	Extinctions
HY15	GO:0050824	water binding	Extinctions
HY15	GO:0050825	ice binding	Extinctions
HY15	GO:0004496	mevalonate kinase activity	Extinctions
HY15	GO:0004772	sterol O-acyltransferase activity	Extinctions
HY15	GO:0035326	enhancer binding	Extinctions
HY15	GO:0001158	enhancer sequence-specific DNA binding	Extinctions
HY15	GO:0004872	receptor activity	Extinctions
HY15	GO:0043394	proteoglycan binding	Extinctions
HY15	GO:0043395	heparan sulfate proteoglycan binding	Extinctions
HY15	GO:0004064	arylesterase activity	Extinctions
HY15	GO:0019992	diacylglycerol binding	Extinctions
HY15	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Extinctions
HY15	GO:0048027	mRNA 5'-UTR binding	Extinctions
HY15	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY15	GO:0060089	molecular transducer activity	Extinctions
HY15	GO:0004871	signal transducer activity	Extinctions
HY15	GO:0008036	diuretic hormone receptor activity	Extinctions
HY15	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	Extinctions
HY15	GO:0001105	RNA polymerase II transcription coactivator activity	Extinctions
57	GO:0003964	RNA-directed DNA polymerase activity	Gains
57	GO:0034061	DNA polymerase activity	Gains
57	GO:0016779	nucleotidyltransferase activity	Gains
57	GO:0140097	catalytic activity, acting on DNA	Gains
57	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
57	GO:0004519	endonuclease activity	Gains
57	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
57	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
57	GO:0004518	nuclease activity	Gains
57	GO:0070001	aspartic-type peptidase activity	Gains
57	GO:0004190	aspartic-type endopeptidase activity	Gains
57	GO:0003676	nucleic acid binding	Gains
57	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
57	GO:0046914	transition metal ion binding	Gains
57	GO:0004521	endoribonuclease activity	Gains
57	GO:0005216	ion channel activity	Gains
57	GO:0022838	substrate-specific channel activity	Gains
57	GO:0008270	zinc ion binding	Gains
57	GO:0005261	cation channel activity	Gains
57	GO:0015267	channel activity	Gains
57	GO:0022803	passive transmembrane transporter activity	Gains
57	GO:0022857	transmembrane transporter activity	Gains
57	GO:0022836	gated channel activity	Gains
57	GO:0046873	metal ion transmembrane transporter activity	Gains
57	GO:0016740	transferase activity	Gains
57	GO:0022890	inorganic cation transmembrane transporter activity	Gains
57	GO:0003723	RNA binding	Gains
57	GO:0015075	ion transmembrane transporter activity	Gains
57	GO:0022891	substrate-specific transmembrane transporter activity	Gains
57	GO:1901363	heterocyclic compound binding	Gains
57	GO:0004540	ribonuclease activity	Gains
57	GO:0097159	organic cyclic compound binding	Gains
57	GO:0008324	cation transmembrane transporter activity	Gains
57	GO:0005549	odorant binding	Gains
57	GO:0005267	potassium channel activity	Gains
57	GO:0022892	substrate-specific transporter activity	Gains
57	GO:0015079	potassium ion transmembrane transporter activity	Gains
57	GO:0022832	voltage-gated channel activity	Gains
57	GO:0005244	voltage-gated ion channel activity	Gains
57	GO:0022843	voltage-gated cation channel activity	Gains
57	GO:0005215	transporter activity	Gains
57	GO:0099094	ligand-gated cation channel activity	Gains
57	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
57	GO:0004984	olfactory receptor activity	Gains
57	GO:0004872	receptor activity	Gains
57	GO:0046906	tetrapyrrole binding	Gains
57	GO:0099600	transmembrane receptor activity	Gains
57	GO:0015085	calcium ion transmembrane transporter activity	Gains
57	GO:0051020	GTPase binding	Gains
57	GO:0038023	signaling receptor activity	Gains
57	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
57	GO:0043169	cation binding	Gains
57	GO:0015276	ligand-gated ion channel activity	Gains
57	GO:0022834	ligand-gated channel activity	Gains
57	GO:0046872	metal ion binding	Gains
57	GO:0060089	molecular transducer activity	Gains
57	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
57	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
57	GO:0008812	choline dehydrogenase activity	Gains
57	GO:0003677	DNA binding	Gains
57	GO:0020037	heme binding	Gains
57	GO:0005249	voltage-gated potassium channel activity	Gains
57	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
57	GO:0070548	L-glutamine aminotransferase activity	Gains
57	GO:0016906	sterol 3-beta-glucosyltransferase activity	Gains
57	GO:0004555	alpha,alpha-trehalase activity	Gains
57	GO:0005000	vasopressin receptor activity	Gains
57	GO:0016781	phosphotransferase activity, paired acceptors	Gains
57	GO:0005384	manganese ion transmembrane transporter activity	Gains
57	GO:0015927	trehalase activity	Gains
57	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
57	GO:0005509	calcium ion binding	Gains
57	GO:0009881	photoreceptor activity	Gains
57	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
57	GO:0004497	monooxygenase activity	Gains
57	GO:0017016	Ras GTPase binding	Gains
57	GO:0004888	transmembrane signaling receptor activity	Gains
57	GO:0005217	intracellular ligand-gated ion channel activity	Gains
57	GO:0031267	small GTPase binding	Gains
57	GO:0034062	5'-3' RNA polymerase activity	Gains
57	GO:0097747	RNA polymerase activity	Gains
57	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
57	GO:0004871	signal transducer activity	Gains
57	GO:0050660	flavin adenine dinucleotide binding	Gains
57	GO:0005262	calcium channel activity	Gains
57	GO:0005381	iron ion transmembrane transporter activity	Gains
57	GO:0032450	maltose alpha-glucosidase activity	Gains
57	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
57	GO:0005488	binding	Gains
57	GO:0004738	pyruvate dehydrogenase activity	Gains
57	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Gains
57	GO:0008613	diuretic hormone activity	Gains
57	GO:0015278	calcium-release channel activity	Gains
57	GO:0008036	diuretic hormone receptor activity	Gains
57	GO:0097642	calcitonin family receptor activity	Gains
57	GO:0004948	calcitonin receptor activity	Gains
57	GO:0099604	ligand-gated calcium channel activity	Gains
57	GO:0042625	ATPase coupled ion transmembrane transporter activity	Gains
57	GO:0019829	cation-transporting ATPase activity	Gains
57	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
57	GO:0008234	cysteine-type peptidase activity	Gains
57	GO:0005506	iron ion binding	Gains
57	GO:0004175	endopeptidase activity	Gains
57	GO:0016787	hydrolase activity	Gains
57	GO:0008233	peptidase activity	Gains
57	GO:0090599	alpha-glucosidase activity	Gains
57	GO:0005245	voltage-gated calcium channel activity	Gains
57	GO:0098772	molecular function regulator	Gains
57	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
57	GO:0016788	hydrolase activity, acting on ester bonds	Gains
57	GO:0005272	sodium channel activity	Gains
57	GO:0005201	extracellular matrix structural constituent	Gains
57	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Losses
57	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Losses
57	GO:0008374	O-acyltransferase activity	Losses
57	GO:0004930	G-protein coupled receptor activity	Losses
57	GO:0016746	transferase activity, transferring acyl groups	Losses
57	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
57	GO:0004872	receptor activity	Losses
57	GO:1901681	sulfur compound binding	Losses
57	GO:0008395	steroid hydroxylase activity	Losses
57	GO:0038023	signaling receptor activity	Losses
57	GO:0060089	molecular transducer activity	Losses
57	GO:0004888	transmembrane signaling receptor activity	Losses
57	GO:1990939	ATP-dependent microtubule motor activity	Losses
57	GO:0016411	acylglycerol O-acyltransferase activity	Losses
57	GO:0016722	oxidoreductase activity, oxidizing metal ions	Losses
57	GO:0043169	cation binding	Losses
57	GO:0004197	cysteine-type endopeptidase activity	Losses
57	GO:0004143	diacylglycerol kinase activity	Losses
57	GO:0004104	cholinesterase activity	Losses
57	GO:0008811	chloramphenicol O-acetyltransferase activity	Losses
57	GO:0030586	[methionine synthase] reductase activity	Losses
57	GO:0070576	vitamin D 24-hydroxylase activity	Losses
57	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
57	GO:0003991	acetylglutamate kinase activity	Losses
57	GO:0050353	trimethyllysine dioxygenase activity	Losses
57	GO:0003919	FMN adenylyltransferase activity	Losses
57	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
57	GO:0019811	cocaine binding	Losses
57	GO:0015222	serotonin transmembrane transporter activity	Losses
57	GO:0004666	prostaglandin-endoperoxide synthase activity	Losses
57	GO:0042943	D-amino acid transmembrane transporter activity	Losses
57	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
57	GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Losses
57	GO:0030366	molybdopterin synthase activity	Losses
57	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
57	GO:0005329	dopamine transmembrane transporter activity	Losses
57	GO:0042263	neuropeptide F receptor activity	Losses
57	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Losses
57	GO:0042767	ecdysteroid 22-hydroxylase activity	Losses
57	GO:0046872	metal ion binding	Losses
57	GO:0004871	signal transducer activity	Losses
57	GO:0003951	NAD+ kinase activity	Losses
57	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
57	GO:0099600	transmembrane receptor activity	Losses
57	GO:0008061	chitin binding	Losses
57	GO:0004930	G-protein coupled receptor activity	Extinctions
57	GO:0038023	signaling receptor activity	Extinctions
57	GO:0004888	transmembrane signaling receptor activity	Extinctions
57	GO:0004872	receptor activity	Extinctions
57	GO:0060089	molecular transducer activity	Extinctions
57	GO:0004871	signal transducer activity	Extinctions
57	GO:0099600	transmembrane receptor activity	Extinctions
57	GO:1990939	ATP-dependent microtubule motor activity	Extinctions
57	GO:0016722	oxidoreductase activity, oxidizing metal ions	Extinctions
57	GO:0004143	diacylglycerol kinase activity	Extinctions
57	GO:0008811	chloramphenicol O-acetyltransferase activity	Extinctions
57	GO:0030586	[methionine synthase] reductase activity	Extinctions
57	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
57	GO:0003991	acetylglutamate kinase activity	Extinctions
57	GO:0050353	trimethyllysine dioxygenase activity	Extinctions
57	GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
57	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
57	GO:0042263	neuropeptide F receptor activity	Extinctions
57	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
57	GO:0003951	NAD+ kinase activity	Extinctions
57	GO:0004623	phospholipase A2 activity	Extinctions
57	GO:0046872	metal ion binding	Extinctions
57	GO:0043169	cation binding	Extinctions
57	GO:0004983	neuropeptide Y receptor activity	Extinctions
57	GO:0004772	sterol O-acyltransferase activity	Extinctions
57	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Extinctions
57	GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	Extinctions
57	GO:0000210	NAD+ diphosphatase activity	Extinctions
57	GO:0001729	ceramide kinase activity	Extinctions
57	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Extinctions
57	GO:0001637	G-protein coupled chemoattractant receptor activity	Extinctions
57	GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	Extinctions
57	GO:0004995	tachykinin receptor activity	Extinctions
57	GO:0004950	chemokine receptor activity	Extinctions
57	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
57	GO:0008470	isovaleryl-CoA dehydrogenase activity	Extinctions
57	GO:0034736	cholesterol O-acyltransferase activity	Extinctions
57	GO:0016505	peptidase activator activity involved in apoptotic process	Extinctions
57	GO:0004170	dUTP diphosphatase activity	Extinctions
57	GO:0008890	glycine C-acetyltransferase activity	Extinctions
CCAPI	GO:0048037	cofactor binding	Gains
CCAPI	GO:0003964	RNA-directed DNA polymerase activity	Gains
CCAPI	GO:0034061	DNA polymerase activity	Gains
CCAPI	GO:0140097	catalytic activity, acting on DNA	Gains
CCAPI	GO:0005215	transporter activity	Gains
CCAPI	GO:0016779	nucleotidyltransferase activity	Gains
CCAPI	GO:0019842	vitamin binding	Gains
CCAPI	GO:0003824	catalytic activity	Gains
CCAPI	GO:0000156	phosphorelay response regulator activity	Gains
CCAPI	GO:0050662	coenzyme binding	Gains
CCAPI	GO:0016491	oxidoreductase activity	Gains
CCAPI	GO:0030170	pyridoxal phosphate binding	Gains
CCAPI	GO:0070279	vitamin B6 binding	Gains
CCAPI	GO:0070001	aspartic-type peptidase activity	Gains
CCAPI	GO:0004190	aspartic-type endopeptidase activity	Gains
CCAPI	GO:0016829	lyase activity	Gains
CCAPI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
CCAPI	GO:0022857	transmembrane transporter activity	Gains
CCAPI	GO:0004930	G-protein coupled receptor activity	Gains
CCAPI	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
CCAPI	GO:0008227	G-protein coupled amine receptor activity	Gains
CCAPI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
CCAPI	GO:0017153	sodium:dicarboxylate symporter activity	Gains
CCAPI	GO:0099589	serotonin receptor activity	Gains
CCAPI	GO:0004993	G-protein coupled serotonin receptor activity	Gains
CCAPI	GO:0043177	organic acid binding	Gains
CCAPI	GO:0031406	carboxylic acid binding	Gains
CCAPI	GO:0015294	solute:cation symporter activity	Gains
CCAPI	GO:0005343	organic acid:sodium symporter activity	Gains
CCAPI	GO:0015291	secondary active transmembrane transporter activity	Gains
CCAPI	GO:0015293	symporter activity	Gains
CCAPI	GO:0004871	signal transducer activity	Gains
CCAPI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
CCAPI	GO:0004673	protein histidine kinase activity	Gains
CCAPI	GO:0050661	NADP binding	Gains
CCAPI	GO:1901681	sulfur compound binding	Gains
CCAPI	GO:0015081	sodium ion transmembrane transporter activity	Gains
CCAPI	GO:0030976	thiamine pyrophosphate binding	Gains
CCAPI	GO:0008172	S-methyltransferase activity	Gains
CCAPI	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
CCAPI	GO:0004070	aspartate carbamoyltransferase activity	Gains
CCAPI	GO:0004977	melanocortin receptor activity	Gains
CCAPI	GO:0016151	nickel cation binding	Gains
CCAPI	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
CCAPI	GO:0038023	signaling receptor activity	Gains
CCAPI	GO:0022804	active transmembrane transporter activity	Gains
CCAPI	GO:0015296	anion:cation symporter activity	Gains
CCAPI	GO:0004872	receptor activity	Gains
CCAPI	GO:0046873	metal ion transmembrane transporter activity	Gains
CCAPI	GO:0016830	carbon-carbon lyase activity	Gains
CCAPI	GO:0016597	amino acid binding	Gains
CCAPI	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
CCAPI	GO:0010181	FMN binding	Gains
CCAPI	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
CCAPI	GO:0016831	carboxy-lyase activity	Gains
CCAPI	GO:0015370	solute:sodium symporter activity	Gains
CCAPI	GO:0008483	transaminase activity	Gains
CCAPI	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
CCAPI	GO:0022891	substrate-specific transmembrane transporter activity	Gains
CCAPI	GO:0015144	carbohydrate transmembrane transporter activity	Gains
CCAPI	GO:0000155	phosphorelay sensor kinase activity	Gains
CCAPI	GO:0019239	deaminase activity	Gains
CCAPI	GO:0008324	cation transmembrane transporter activity	Gains
CCAPI	GO:0004000	adenosine deaminase activity	Gains
CCAPI	GO:0060089	molecular transducer activity	Gains
CCAPI	GO:0009055	electron transfer activity	Gains
CCAPI	GO:0016840	carbon-nitrogen lyase activity	Gains
CCAPI	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
CCAPI	GO:0008658	penicillin binding	Gains
CCAPI	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Gains
CCAPI	GO:0015075	ion transmembrane transporter activity	Gains
CCAPI	GO:0022892	substrate-specific transporter activity	Gains
CCAPI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
CCAPI	GO:0016740	transferase activity	Gains
CCAPI	GO:0003700	DNA binding transcription factor activity	Gains
CCAPI	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
CCAPI	GO:0051287	NAD binding	Gains
CCAPI	GO:0019992	diacylglycerol binding	Gains
CCAPI	GO:0008681	2-octaprenyl-6-methoxyphenol hydroxylase activity	Gains
CCAPI	GO:0043115	precorrin-2 dehydrogenase activity	Gains
CCAPI	GO:0004068	aspartate 1-decarboxylase activity	Gains
CCAPI	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Gains
CCAPI	GO:0004950	chemokine receptor activity	Gains
CCAPI	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Gains
CCAPI	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
CCAPI	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
CCAPI	GO:0009039	urease activity	Gains
CCAPI	GO:0008332	low voltage-gated calcium channel activity	Gains
CCAPI	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	Gains
CCAPI	GO:0004803	transposase activity	Gains
CCAPI	GO:0008171	O-methyltransferase activity	Gains
CCAPI	GO:0099600	transmembrane receptor activity	Gains
CCAPI	GO:0004888	transmembrane signaling receptor activity	Gains
CCAPI	GO:0022890	inorganic cation transmembrane transporter activity	Gains
CCAPI	GO:0004983	neuropeptide Y receptor activity	Gains
CCAPI	GO:0051119	sugar transmembrane transporter activity	Gains
CCAPI	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
CCAPI	GO:0033293	monocarboxylic acid binding	Gains
CCAPI	GO:0019203	carbohydrate phosphatase activity	Gains
CCAPI	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
CCAPI	GO:0050660	flavin adenine dinucleotide binding	Gains
CCAPI	GO:0005402	cation:sugar symporter activity	Gains
CCAPI	GO:0015295	solute:proton symporter activity	Gains
CCAPI	GO:0005351	sugar:proton symporter activity	Gains
CCAPI	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
CCAPI	GO:0016849	phosphorus-oxygen lyase activity	Gains
CCAPI	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Gains
CCAPI	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
CCAPI	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
CCAPI	GO:0008509	anion transmembrane transporter activity	Gains
CCAPI	GO:0004984	olfactory receptor activity	Losses
CCAPI	GO:0005549	odorant binding	Losses
CCAPI	GO:0004930	G-protein coupled receptor activity	Losses
CCAPI	GO:0005201	extracellular matrix structural constituent	Losses
CCAPI	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
CCAPI	GO:0019239	deaminase activity	Losses
CCAPI	GO:0008812	choline dehydrogenase activity	Losses
CCAPI	GO:0019825	oxygen binding	Losses
CCAPI	GO:0016755	transferase activity, transferring amino-acyl groups	Losses
CCAPI	GO:0004857	enzyme inhibitor activity	Losses
CCAPI	GO:0004252	serine-type endopeptidase activity	Losses
CCAPI	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Losses
CCAPI	GO:0052692	raffinose alpha-galactosidase activity	Losses
CCAPI	GO:0016503	pheromone receptor activity	Losses
CCAPI	GO:0004566	beta-glucuronidase activity	Losses
CCAPI	GO:0004557	alpha-galactosidase activity	Losses
CCAPI	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
CCAPI	GO:0033192	calmodulin-dependent protein phosphatase activity	Losses
CCAPI	GO:0050111	mycocerosate synthase activity	Losses
CCAPI	GO:0042577	lipid phosphatase activity	Losses
CCAPI	GO:0016936	galactoside binding	Losses
CCAPI	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
CCAPI	GO:0047875	ecdysone oxidase activity	Losses
CCAPI	GO:0035368	selenocysteine insertion sequence binding	Losses
CCAPI	GO:0031370	eukaryotic initiation factor 4G binding	Losses
CCAPI	GO:0033677	DNA/RNA helicase activity	Losses
CCAPI	GO:0035175	histone kinase activity (H3-S10 specific)	Losses
CCAPI	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
CCAPI	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
CCAPI	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
CCAPI	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
CCAPI	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
CCAPI	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
CCAPI	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
CCAPI	GO:0008473	ornithine cyclodeaminase activity	Losses
CCAPI	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Losses
CCAPI	GO:0051538	3 iron, 4 sulfur cluster binding	Losses
CCAPI	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Losses
CCAPI	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
CCAPI	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
CCAPI	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
CCAPI	GO:0004153	dihydropterin deaminase activity	Losses
CCAPI	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Losses
CCAPI	GO:0003839	gamma-glutamylcyclotransferase activity	Losses
CCAPI	GO:0071860	proctolin receptor binding	Losses
CCAPI	GO:0004126	cytidine deaminase activity	Losses
CCAPI	GO:0004131	cytosine deaminase activity	Losses
CCAPI	GO:0000257	nitrilase activity	Losses
CCAPI	GO:0032183	SUMO binding	Losses
CCAPI	GO:0008768	UDP-sugar diphosphatase activity	Losses
CCAPI	GO:0004791	thioredoxin-disulfide reductase activity	Losses
CCAPI	GO:0008301	DNA binding, bending	Losses
CCAPI	GO:0050660	flavin adenine dinucleotide binding	Losses
CCAPI	GO:0004622	lysophospholipase activity	Losses
CCAPI	GO:0017022	myosin binding	Losses
CCAPI	GO:0004888	transmembrane signaling receptor activity	Losses
CCAPI	GO:0004984	olfactory receptor activity	Extinctions
CCAPI	GO:0005549	odorant binding	Extinctions
CCAPI	GO:0004930	G-protein coupled receptor activity	Extinctions
CCAPI	GO:0019825	oxygen binding	Extinctions
CCAPI	GO:0005201	extracellular matrix structural constituent	Extinctions
CCAPI	GO:0008301	DNA binding, bending	Extinctions
CCAPI	GO:0016503	pheromone receptor activity	Extinctions
CCAPI	GO:0047875	ecdysone oxidase activity	Extinctions
CCAPI	GO:0035368	selenocysteine insertion sequence binding	Extinctions
CCAPI	GO:0033677	DNA/RNA helicase activity	Extinctions
CCAPI	GO:0008473	ornithine cyclodeaminase activity	Extinctions
CCAPI	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Extinctions
CCAPI	GO:0070611	histone methyltransferase activity (H3-R2 specific)	Extinctions
CCAPI	GO:0004153	dihydropterin deaminase activity	Extinctions
CCAPI	GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity	Extinctions
CCAPI	GO:0071860	proctolin receptor binding	Extinctions
CCAPI	GO:0071855	neuropeptide receptor binding	Extinctions
CCAPI	GO:0004888	transmembrane signaling receptor activity	Extinctions
CCAPI	GO:0008892	guanine deaminase activity	Extinctions
CCAPI	GO:0016084	myostimulatory hormone activity	Extinctions
CCAPI	GO:0008020	G-protein coupled photoreceptor activity	Extinctions
CCAPI	GO:0004054	arginine kinase activity	Extinctions
CCAPI	GO:0001096	TFIIF-class transcription factor binding	Extinctions
CCAPI	GO:0004170	dUTP diphosphatase activity	Extinctions
CCAPI	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Extinctions
CCAPI	GO:0043014	alpha-tubulin binding	Extinctions
CCAPI	GO:0008255	ecdysis-triggering hormone activity	Extinctions
CCAPI	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
51	GO:0003964	RNA-directed DNA polymerase activity	Gains
51	GO:0034061	DNA polymerase activity	Gains
51	GO:0016779	nucleotidyltransferase activity	Gains
51	GO:0140097	catalytic activity, acting on DNA	Gains
51	GO:0004930	G-protein coupled receptor activity	Gains
51	GO:0004888	transmembrane signaling receptor activity	Gains
51	GO:0038023	signaling receptor activity	Gains
51	GO:0004190	aspartic-type endopeptidase activity	Gains
51	GO:0070001	aspartic-type peptidase activity	Gains
51	GO:0099600	transmembrane receptor activity	Gains
51	GO:0004871	signal transducer activity	Gains
51	GO:0004872	receptor activity	Gains
51	GO:0004965	G-protein coupled GABA receptor activity	Gains
51	GO:0008233	peptidase activity	Gains
51	GO:0020037	heme binding	Gains
51	GO:0046906	tetrapyrrole binding	Gains
51	GO:0005549	odorant binding	Gains
51	GO:0048018	receptor ligand activity	Gains
51	GO:0004497	monooxygenase activity	Gains
51	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
51	GO:0016917	GABA receptor activity	Gains
51	GO:0004000	adenosine deaminase activity	Gains
51	GO:0060089	molecular transducer activity	Gains
51	GO:0004175	endopeptidase activity	Gains
51	GO:0005506	iron ion binding	Gains
51	GO:0046914	transition metal ion binding	Gains
51	GO:0030545	receptor regulator activity	Gains
51	GO:0016209	antioxidant activity	Gains
51	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Gains
51	GO:0018445	prothoracicotrophic hormone activity	Gains
51	GO:0004634	phosphopyruvate hydratase activity	Gains
51	GO:0001642	group III metabotropic glutamate receptor activity	Gains
51	GO:0004054	arginine kinase activity	Gains
51	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Gains
51	GO:0015250	water channel activity	Gains
51	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
51	GO:0052722	fatty acid in-chain hydroxylase activity	Gains
51	GO:0071837	HMG box domain binding	Gains
51	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Gains
51	GO:0005372	water transmembrane transporter activity	Gains
51	GO:0046790	virion binding	Gains
51	GO:0004499	N,N-dimethylaniline monooxygenase activity	Gains
51	GO:0035274	diphenyl phthalate binding	Gains
51	GO:0035275	dibutyl phthalate binding	Gains
51	GO:0005122	torso binding	Gains
51	GO:0016595	glutamate binding	Gains
51	GO:0001106	RNA polymerase II transcription corepressor activity	Gains
51	GO:0071906	CRD domain binding	Gains
51	GO:0033932	1,3-alpha-L-fucosidase activity	Gains
51	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
51	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
51	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
51	GO:0070491	repressing transcription factor binding	Gains
51	GO:0019239	deaminase activity	Gains
51	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
51	GO:0005550	pheromone binding	Gains
51	GO:0004560	alpha-L-fucosidase activity	Gains
51	GO:0004555	alpha,alpha-trehalase activity	Gains
51	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
51	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
51	GO:0015459	potassium channel regulator activity	Gains
51	GO:0015485	cholesterol binding	Gains
51	GO:0019202	amino acid kinase activity	Gains
51	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Gains
51	GO:0001641	group II metabotropic glutamate receptor activity	Gains
51	GO:0050591	quinine 3-monooxygenase activity	Gains
51	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
51	GO:0005212	structural constituent of eye lens	Gains
51	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Gains
51	GO:0098988	G-protein coupled glutamate receptor activity	Gains
51	GO:0001103	RNA polymerase II repressing transcription factor binding	Gains
51	GO:0015927	trehalase activity	Gains
51	GO:0015928	fucosidase activity	Gains
51	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
51	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
51	GO:0001104	RNA polymerase II transcription cofactor activity	Gains
51	GO:0004806	triglyceride lipase activity	Gains
51	GO:0003723	RNA binding	Gains
51	GO:0016491	oxidoreductase activity	Gains
51	GO:0003677	DNA binding	Gains
51	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
51	GO:0042302	structural constituent of cuticle	Losses
51	GO:0019238	cyclohydrolase activity	Losses
51	GO:0004930	G-protein coupled receptor activity	Losses
51	GO:0008188	neuropeptide receptor activity	Losses
51	GO:0005215	transporter activity	Losses
51	GO:0016411	acylglycerol O-acyltransferase activity	Losses
51	GO:0004844	uracil DNA N-glycosylase activity	Losses
51	GO:0005537	mannose binding	Losses
51	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
51	GO:0004666	prostaglandin-endoperoxide synthase activity	Losses
51	GO:0019153	protein-disulfide reductase (glutathione) activity	Losses
51	GO:0009032	thymidine phosphorylase activity	Losses
51	GO:0008022	protein C-terminus binding	Losses
51	GO:0045294	alpha-catenin binding	Losses
51	GO:0097506	deaminated base DNA N-glycosylase activity	Losses
51	GO:0015145	monosaccharide transmembrane transporter activity	Losses
51	GO:0015149	hexose transmembrane transporter activity	Losses
51	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
51	GO:0008458	carnitine O-octanoyltransferase activity	Losses
51	GO:0042301	phosphate ion binding	Losses
51	GO:0016414	O-octanoyltransferase activity	Losses
51	GO:0004372	glycine hydroxymethyltransferase activity	Losses
51	GO:0004324	ferredoxin-NADP+ reductase activity	Losses
51	GO:0004329	formate-tetrahydrofolate ligase activity	Losses
51	GO:0016154	pyrimidine-nucleoside phosphorylase activity	Losses
51	GO:0015578	mannose transmembrane transporter activity	Losses
51	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Losses
51	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Losses
51	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Losses
51	GO:0035236	proctolin receptor activity	Losses
51	GO:0004170	dUTP diphosphatase activity	Losses
51	GO:0097493	structural molecule activity conferring elasticity	Losses
51	GO:0008810	cellulase activity	Losses
51	GO:0016524	latrotoxin receptor activity	Losses
51	GO:0008528	G-protein coupled peptide receptor activity	Losses
51	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
51	GO:0004601	peroxidase activity	Losses
51	GO:0008374	O-acyltransferase activity	Losses
51	GO:0001653	peptide receptor activity	Losses
51	GO:0001871	pattern binding	Losses
51	GO:0030247	polysaccharide binding	Losses
51	GO:0099600	transmembrane receptor activity	Losses
51	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Novel expansions
51	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Novel expansions
51	GO:0042302	structural constituent of cuticle	Extinctions
51	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Extinctions
51	GO:0004601	peroxidase activity	Extinctions
51	GO:0004844	uracil DNA N-glycosylase activity	Extinctions
51	GO:0005537	mannose binding	Extinctions
51	GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
51	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
51	GO:0009032	thymidine phosphorylase activity	Extinctions
51	GO:0008022	protein C-terminus binding	Extinctions
51	GO:0097506	deaminated base DNA N-glycosylase activity	Extinctions
51	GO:0015145	monosaccharide transmembrane transporter activity	Extinctions
51	GO:0015149	hexose transmembrane transporter activity	Extinctions
51	GO:0008458	carnitine O-octanoyltransferase activity	Extinctions
51	GO:0016414	O-octanoyltransferase activity	Extinctions
51	GO:0016154	pyrimidine-nucleoside phosphorylase activity	Extinctions
51	GO:0015578	mannose transmembrane transporter activity	Extinctions
51	GO:0035236	proctolin receptor activity	Extinctions
51	GO:0004170	dUTP diphosphatase activity	Extinctions
51	GO:0008810	cellulase activity	Extinctions
51	GO:0001871	pattern binding	Extinctions
51	GO:0030247	polysaccharide binding	Extinctions
51	GO:0016209	antioxidant activity	Extinctions
51	GO:0008188	neuropeptide receptor activity	Extinctions
51	GO:0000210	NAD+ diphosphatase activity	Extinctions
51	GO:0003933	GTP cyclohydrolase activity	Extinctions
51	GO:0003934	GTP cyclohydrolase I activity	Extinctions
51	GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Extinctions
51	GO:0016415	octanoyltransferase activity	Extinctions
51	GO:0008890	glycine C-acetyltransferase activity	Extinctions
51	GO:0047220	galactosylxylosylprotein 3-beta-galactosyltransferase activity	Extinctions
51	GO:0004797	thymidine kinase activity	Extinctions
50	GO:0003964	RNA-directed DNA polymerase activity	Gains
50	GO:0034061	DNA polymerase activity	Gains
50	GO:0140097	catalytic activity, acting on DNA	Gains
50	GO:0016779	nucleotidyltransferase activity	Gains
50	GO:0046914	transition metal ion binding	Gains
50	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
50	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
50	GO:0043169	cation binding	Gains
50	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
50	GO:0008270	zinc ion binding	Gains
50	GO:0046872	metal ion binding	Gains
50	GO:0020037	heme binding	Gains
50	GO:0004190	aspartic-type endopeptidase activity	Gains
50	GO:0070001	aspartic-type peptidase activity	Gains
50	GO:0046906	tetrapyrrole binding	Gains
50	GO:0005214	structural constituent of chitin-based cuticle	Gains
50	GO:0004497	monooxygenase activity	Gains
50	GO:0042834	peptidoglycan binding	Gains
50	GO:0018685	alkane 1-monooxygenase activity	Gains
50	GO:0005212	structural constituent of eye lens	Gains
50	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
50	GO:0005272	sodium channel activity	Gains
50	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
50	GO:0050660	flavin adenine dinucleotide binding	Gains
50	GO:0042302	structural constituent of cuticle	Gains
50	GO:0030246	carbohydrate binding	Gains
50	GO:0004519	endonuclease activity	Gains
50	GO:0097642	calcitonin family receptor activity	Gains
50	GO:0004948	calcitonin receptor activity	Gains
50	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Gains
50	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
50	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
50	GO:0008036	diuretic hormone receptor activity	Gains
50	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
50	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
50	GO:0005506	iron ion binding	Gains
50	GO:0004518	nuclease activity	Gains
50	GO:0008061	chitin binding	Gains
50	GO:0032403	protein complex binding	Gains
50	GO:0016788	hydrolase activity, acting on ester bonds	Gains
50	GO:0035250	UDP-galactosyltransferase activity	Gains
50	GO:0038187	pattern recognition receptor activity	Gains
50	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Gains
50	GO:0008329	signaling pattern recognition receptor activity	Gains
50	GO:0033549	MAP kinase phosphatase activity	Gains
50	GO:0045289	luciferin monooxygenase activity	Gains
50	GO:0015081	sodium ion transmembrane transporter activity	Gains
50	GO:0016491	oxidoreductase activity	Gains
50	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
50	GO:0048037	cofactor binding	Gains
50	GO:0016215	acyl-CoA desaturase activity	Gains
50	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
50	GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
50	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
50	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
50	GO:0050662	coenzyme binding	Gains
50	GO:0044877	macromolecular complex binding	Gains
50	GO:0008378	galactosyltransferase activity	Gains
50	GO:0004016	adenylate cyclase activity	Gains
50	GO:0004180	carboxypeptidase activity	Gains
50	GO:0004806	triglyceride lipase activity	Gains
50	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
50	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
50	GO:0005245	voltage-gated calcium channel activity	Gains
50	GO:0070330	aromatase activity	Gains
50	GO:0008188	neuropeptide receptor activity	Gains
50	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
50	GO:0022890	inorganic cation transmembrane transporter activity	Gains
50	GO:0052689	carboxylic ester hydrolase activity	Gains
50	GO:0015299	solute:proton antiporter activity	Gains
50	GO:0004089	carbonate dehydratase activity	Gains
50	GO:0008395	steroid hydroxylase activity	Gains
50	GO:0030165	PDZ domain binding	Gains
50	GO:0003676	nucleic acid binding	Gains
50	GO:0015280	ligand-gated sodium channel activity	Gains
50	GO:0004096	catalase activity	Gains
50	GO:0004097	catechol oxidase activity	Gains
50	GO:0032500	muramyl dipeptide binding	Gains
50	GO:0010461	light-activated ion channel activity	Gains
50	GO:0004068	aspartate 1-decarboxylase activity	Gains
50	GO:0004055	argininosuccinate synthase activity	Gains
50	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Gains
50	GO:0018833	DDT-dehydrochlorinase activity	Gains
50	GO:0044736	acid-sensing ion channel activity	Gains
50	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Gains
50	GO:0004946	bombesin receptor activity	Gains
50	GO:0008331	high voltage-gated calcium channel activity	Gains
50	GO:0001082	transcription factor activity, RNA polymerase I transcription factor binding	Gains
50	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
50	GO:0001046	core promoter sequence-specific DNA binding	Gains
50	GO:0008456	alpha-N-acetylgalactosaminidase activity	Gains
50	GO:0016160	amylase activity	Gains
50	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Gains
50	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Gains
50	GO:0004351	glutamate decarboxylase activity	Gains
50	GO:0031473	myosin III binding	Gains
50	GO:0004321	fatty-acyl-CoA synthase activity	Gains
50	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
50	GO:0052870	tocopherol omega-hydroxylase activity	Gains
50	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
50	GO:0016231	beta-N-acetylglucosaminidase activity	Gains
50	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	Gains
50	GO:0004466	long-chain-acyl-CoA dehydrogenase activity	Gains
50	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
50	GO:0070576	vitamin D 24-hydroxylase activity	Gains
50	GO:0004167	dopachrome isomerase activity	Gains
50	GO:0052692	raffinose alpha-galactosidase activity	Gains
50	GO:0042768	ecdysteroid 2-hydroxylase activity	Gains
50	GO:0008747	N-acetylneuraminate lyase activity	Gains
50	GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding	Gains
50	GO:0001167	RNA polymerase I transcription factor activity, sequence-specific DNA binding	Gains
50	GO:0008801	beta-phosphoglucomutase activity	Gains
50	GO:0001169	transcription factor activity, RNA polymerase I CORE element sequence-specific binding	Gains
50	GO:0036263	L-DOPA monooxygenase activity	Gains
50	GO:0036264	dopamine monooxygenase activity	Gains
50	GO:0001186	transcription factor activity, RNA polymerase I transcription factor recruiting	Gains
50	GO:0001187	transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting	Gains
50	GO:0004796	thromboxane-A synthase activity	Gains
50	GO:0042806	fucose binding	Gains
50	GO:0001134	transcription factor activity, transcription factor recruiting	Gains
50	GO:0004782	sulfinoalanine decarboxylase activity	Gains
50	GO:0032183	SUMO binding	Gains
50	GO:0001222	transcription corepressor binding	Gains
50	GO:0001226	RNA polymerase II transcription corepressor binding	Gains
50	GO:0047880	erythrulose reductase activity	Gains
50	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Gains
50	GO:0004556	alpha-amylase activity	Gains
50	GO:0004557	alpha-galactosidase activity	Gains
50	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Gains
50	GO:0004517	nitric-oxide synthase activity	Gains
50	GO:0035013	myosuppressin receptor activity	Gains
50	GO:0001875	lipopolysaccharide receptor activity	Gains
50	GO:0016019	peptidoglycan receptor activity	Gains
50	GO:0004666	prostaglandin-endoperoxide synthase activity	Gains
50	GO:0008086	light-activated voltage-gated calcium channel activity	Gains
50	GO:0003700	DNA binding transcription factor activity	Gains
50	GO:0016758	transferase activity, transferring hexosyl groups	Gains
50	GO:0003995	acyl-CoA dehydrogenase activity	Gains
50	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
50	GO:0005516	calmodulin binding	Gains
50	GO:0005539	glycosaminoglycan binding	Gains
50	GO:0004601	peroxidase activity	Gains
50	GO:0005488	binding	Gains
50	GO:0008238	exopeptidase activity	Gains
50	GO:0005261	cation channel activity	Gains
50	GO:0004687	myosin light chain kinase activity	Losses
50	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
50	GO:0004935	adrenergic receptor activity	Losses
50	GO:0046332	SMAD binding	Losses
50	GO:0015245	fatty acid transporter activity	Losses
50	GO:0070410	co-SMAD binding	Losses
50	GO:0035368	selenocysteine insertion sequence binding	Losses
50	GO:0015204	urea transmembrane transporter activity	Losses
50	GO:0005009	insulin-activated receptor activity	Losses
50	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Losses
50	GO:0045552	dihydrokaempferol 4-reductase activity	Losses
50	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Losses
50	GO:0033867	Fas-activated serine/threonine kinase activity	Losses
50	GO:0035184	histone threonine kinase activity	Losses
50	GO:0000016	lactase activity	Losses
50	GO:0043916	DNA-7-methylguanine glycosylase activity	Losses
50	GO:0005324	long-chain fatty acid transporter activity	Losses
50	GO:0047326	inositol tetrakisphosphate 5-kinase activity	Losses
50	GO:0052821	DNA-7-methyladenine glycosylase activity	Losses
50	GO:0052822	DNA-3-methylguanine glycosylase activity	Losses
50	GO:0016785	transferase activity, transferring selenium-containing groups	Losses
50	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Losses
50	GO:0050080	malonyl-CoA decarboxylase activity	Losses
50	GO:0008725	DNA-3-methyladenine glycosylase activity	Losses
50	GO:0004131	cytosine deaminase activity	Losses
50	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
50	GO:0004769	steroid delta-isomerase activity	Losses
50	GO:0047747	cholate-CoA ligase activity	Losses
50	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
50	GO:0051425	PTB domain binding	Losses
50	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
50	GO:0001735	prenylcysteine oxidase activity	Losses
50	GO:0043733	DNA-3-methylbase glycosylase activity	Losses
50	GO:0003919	FMN adenylyltransferase activity	Losses
50	GO:0003905	alkylbase DNA N-glycosylase activity	Losses
50	GO:0000823	inositol-1,4,5-trisphosphate 6-kinase activity	Losses
50	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
50	GO:0043560	insulin receptor substrate binding	Losses
50	GO:0043559	insulin binding	Losses
50	GO:0004970	ionotropic glutamate receptor activity	Losses
50	GO:0022824	transmitter-gated ion channel activity	Losses
50	GO:0022835	transmitter-gated channel activity	Losses
50	GO:0004167	dopachrome isomerase activity	Novel expansions
50	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Novel expansions
50	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Novel expansions
50	GO:0022890	inorganic cation transmembrane transporter activity	Novel expansions
50	GO:0005215	transporter activity	Novel expansions
50	GO:0005272	sodium channel activity	Novel expansions
50	GO:0008324	cation transmembrane transporter activity	Novel expansions
50	GO:0004177	aminopeptidase activity	Novel expansions
50	GO:0019205	nucleobase-containing compound kinase activity	Novel expansions
50	GO:0004687	myosin light chain kinase activity	Extinctions
50	GO:0004970	ionotropic glutamate receptor activity	Extinctions
50	GO:0022824	transmitter-gated ion channel activity	Extinctions
50	GO:0022835	transmitter-gated channel activity	Extinctions
50	GO:0035368	selenocysteine insertion sequence binding	Extinctions
50	GO:0015204	urea transmembrane transporter activity	Extinctions
50	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
50	GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
50	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
50	GO:0033867	Fas-activated serine/threonine kinase activity	Extinctions
50	GO:0000016	lactase activity	Extinctions
50	GO:0043916	DNA-7-methylguanine glycosylase activity	Extinctions
50	GO:0047326	inositol tetrakisphosphate 5-kinase activity	Extinctions
50	GO:0052821	DNA-7-methyladenine glycosylase activity	Extinctions
50	GO:0052822	DNA-3-methylguanine glycosylase activity	Extinctions
50	GO:0016785	transferase activity, transferring selenium-containing groups	Extinctions
50	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
50	GO:0050080	malonyl-CoA decarboxylase activity	Extinctions
50	GO:0008725	DNA-3-methyladenine glycosylase activity	Extinctions
50	GO:0004769	steroid delta-isomerase activity	Extinctions
50	GO:0001735	prenylcysteine oxidase activity	Extinctions
50	GO:0043733	DNA-3-methylbase glycosylase activity	Extinctions
50	GO:0003905	alkylbase DNA N-glycosylase activity	Extinctions
50	GO:0000823	inositol-1,4,5-trisphosphate 6-kinase activity	Extinctions
50	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
50	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
50	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Extinctions
50	GO:0008066	glutamate receptor activity	Extinctions
MDOME	GO:0003964	RNA-directed DNA polymerase activity	Gains
MDOME	GO:0070001	aspartic-type peptidase activity	Gains
MDOME	GO:0004190	aspartic-type endopeptidase activity	Gains
MDOME	GO:0015291	secondary active transmembrane transporter activity	Gains
MDOME	GO:0015075	ion transmembrane transporter activity	Gains
MDOME	GO:0022857	transmembrane transporter activity	Gains
MDOME	GO:0005215	transporter activity	Gains
MDOME	GO:0022892	substrate-specific transporter activity	Gains
MDOME	GO:0022804	active transmembrane transporter activity	Gains
MDOME	GO:0034061	DNA polymerase activity	Gains
MDOME	GO:0022891	substrate-specific transmembrane transporter activity	Gains
MDOME	GO:0015293	symporter activity	Gains
MDOME	GO:0046873	metal ion transmembrane transporter activity	Gains
MDOME	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
MDOME	GO:0015081	sodium ion transmembrane transporter activity	Gains
MDOME	GO:0005509	calcium ion binding	Gains
MDOME	GO:0008324	cation transmembrane transporter activity	Gains
MDOME	GO:0015294	solute:cation symporter activity	Gains
MDOME	GO:0004857	enzyme inhibitor activity	Gains
MDOME	GO:0016740	transferase activity	Gains
MDOME	GO:0004674	protein serine/threonine kinase activity	Gains
MDOME	GO:0022890	inorganic cation transmembrane transporter activity	Gains
MDOME	GO:0008509	anion transmembrane transporter activity	Gains
MDOME	GO:0015370	solute:sodium symporter activity	Gains
MDOME	GO:0004984	olfactory receptor activity	Gains
MDOME	GO:0030234	enzyme regulator activity	Gains
MDOME	GO:0004672	protein kinase activity	Gains
MDOME	GO:0008092	cytoskeletal protein binding	Gains
MDOME	GO:0050839	cell adhesion molecule binding	Gains
MDOME	GO:0022836	gated channel activity	Gains
MDOME	GO:0004725	protein tyrosine phosphatase activity	Gains
MDOME	GO:0004180	carboxypeptidase activity	Gains
MDOME	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
MDOME	GO:0015296	anion:cation symporter activity	Gains
MDOME	GO:0015103	inorganic anion transmembrane transporter activity	Gains
MDOME	GO:0030414	peptidase inhibitor activity	Gains
MDOME	GO:0099516	ion antiporter activity	Gains
MDOME	GO:0022838	substrate-specific channel activity	Gains
MDOME	GO:0008603	cAMP-dependent protein kinase regulator activity	Gains
MDOME	GO:0004691	cAMP-dependent protein kinase activity	Gains
MDOME	GO:0031683	G-protein beta/gamma-subunit complex binding	Gains
MDOME	GO:0004344	glucose dehydrogenase activity	Gains
MDOME	GO:0015267	channel activity	Gains
MDOME	GO:0022803	passive transmembrane transporter activity	Gains
MDOME	GO:0019899	enzyme binding	Gains
MDOME	GO:0005216	ion channel activity	Gains
MDOME	GO:0032403	protein complex binding	Gains
MDOME	GO:0015085	calcium ion transmembrane transporter activity	Gains
MDOME	GO:0061135	endopeptidase regulator activity	Gains
MDOME	GO:0016301	kinase activity	Gains
MDOME	GO:0004866	endopeptidase inhibitor activity	Gains
MDOME	GO:0005549	odorant binding	Gains
MDOME	GO:0022853	active ion transmembrane transporter activity	Gains
MDOME	GO:0044877	macromolecular complex binding	Gains
MDOME	GO:0004535	poly(A)-specific ribonuclease activity	Gains
MDOME	GO:0008374	O-acyltransferase activity	Gains
MDOME	GO:0004871	signal transducer activity	Gains
MDOME	GO:0008514	organic anion transmembrane transporter activity	Gains
MDOME	GO:0019900	kinase binding	Gains
MDOME	GO:0008146	sulfotransferase activity	Gains
MDOME	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
MDOME	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
MDOME	GO:0098772	molecular function regulator	Gains
MDOME	GO:0005342	organic acid transmembrane transporter activity	Gains
MDOME	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
MDOME	GO:0015368	calcium:cation antiporter activity	Gains
MDOME	GO:0016406	carnitine O-acyltransferase activity	Gains
MDOME	GO:0005178	integrin binding	Gains
MDOME	GO:0008889	glycerophosphodiester phosphodiesterase activity	Gains
MDOME	GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
MDOME	GO:0061659	ubiquitin-like protein ligase activity	Gains
MDOME	GO:0061630	ubiquitin protein ligase activity	Gains
MDOME	GO:0008061	chitin binding	Gains
MDOME	GO:0016791	phosphatase activity	Gains
MDOME	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
MDOME	GO:0003779	actin binding	Gains
MDOME	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
MDOME	GO:0061134	peptidase regulator activity	Gains
MDOME	GO:0140097	catalytic activity, acting on DNA	Gains
MDOME	GO:0042578	phosphoric ester hydrolase activity	Gains
MDOME	GO:0005343	organic acid:sodium symporter activity	Gains
MDOME	GO:0008195	phosphatidate phosphatase activity	Gains
MDOME	GO:0015297	antiporter activity	Gains
MDOME	GO:0004181	metallocarboxypeptidase activity	Gains
MDOME	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
MDOME	GO:0035591	signaling adaptor activity	Gains
MDOME	GO:0015491	cation:cation antiporter activity	Gains
MDOME	GO:0005328	neurotransmitter:sodium symporter activity	Gains
MDOME	GO:0004712	protein serine/threonine/tyrosine kinase activity	Gains
MDOME	GO:0008017	microtubule binding	Gains
MDOME	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
MDOME	GO:0005244	voltage-gated ion channel activity	Gains
MDOME	GO:0022832	voltage-gated channel activity	Gains
MDOME	GO:0005515	protein binding	Gains
MDOME	GO:0046872	metal ion binding	Gains
MDOME	GO:0060089	molecular transducer activity	Gains
MDOME	GO:0043169	cation binding	Gains
MDOME	GO:0015108	chloride transmembrane transporter activity	Gains
MDOME	GO:0005057	signal transducer activity, downstream of receptor	Gains
MDOME	GO:0016788	hydrolase activity, acting on ester bonds	Gains
MDOME	GO:0019901	protein kinase binding	Gains
MDOME	GO:0015238	drug transmembrane transporter activity	Gains
MDOME	GO:0061783	peptidoglycan muralytic activity	Gains
MDOME	GO:0090484	drug transporter activity	Gains
MDOME	GO:0015925	galactosidase activity	Gains
MDOME	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
MDOME	GO:0033041	sweet taste receptor activity	Gains
MDOME	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
MDOME	GO:0005078	MAP-kinase scaffold activity	Gains
MDOME	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
MDOME	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Gains
MDOME	GO:0015116	sulfate transmembrane transporter activity	Gains
MDOME	GO:0019838	growth factor binding	Gains
MDOME	GO:0015278	calcium-release channel activity	Gains
MDOME	GO:0008381	mechanically-gated ion channel activity	Gains
MDOME	GO:0035014	phosphatidylinositol 3-kinase regulator activity	Gains
MDOME	GO:1901618	organic hydroxy compound transmembrane transporter activity	Gains
MDOME	GO:0045159	myosin II binding	Gains
MDOME	GO:0005432	calcium:sodium antiporter activity	Gains
MDOME	GO:0099604	ligand-gated calcium channel activity	Gains
MDOME	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Gains
MDOME	GO:0022833	mechanically gated channel activity	Gains
MDOME	GO:0033868	Goodpasture-antigen-binding protein kinase activity	Gains
MDOME	GO:0140096	catalytic activity, acting on a protein	Gains
MDOME	GO:0015276	ligand-gated ion channel activity	Gains
MDOME	GO:0022834	ligand-gated channel activity	Gains
MDOME	GO:0005548	phospholipid transporter activity	Gains
MDOME	GO:0015298	solute:cation antiporter activity	Gains
MDOME	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Gains
MDOME	GO:0046914	transition metal ion binding	Gains
MDOME	GO:0030551	cyclic nucleotide binding	Gains
MDOME	GO:0008308	voltage-gated anion channel activity	Gains
MDOME	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
MDOME	GO:0001102	RNA polymerase II activating transcription factor binding	Gains
MDOME	GO:0032027	myosin light chain binding	Gains
MDOME	GO:0005086	ARF guanyl-nucleotide exchange factor activity	Gains
MDOME	GO:0016411	acylglycerol O-acyltransferase activity	Gains
MDOME	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
MDOME	GO:0008812	choline dehydrogenase activity	Gains
MDOME	GO:0099094	ligand-gated cation channel activity	Gains
MDOME	GO:0003677	DNA binding	Losses
MDOME	GO:0043565	sequence-specific DNA binding	Losses
MDOME	GO:0005200	structural constituent of cytoskeleton	Losses
MDOME	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
MDOME	GO:0019239	deaminase activity	Losses
MDOME	GO:0008301	DNA binding, bending	Losses
MDOME	GO:0008252	nucleotidase activity	Losses
MDOME	GO:0003700	DNA binding transcription factor activity	Losses
MDOME	GO:0140110	transcription regulator activity	Losses
MDOME	GO:0003774	motor activity	Losses
MDOME	GO:0003690	double-stranded DNA binding	Losses
MDOME	GO:0070330	aromatase activity	Losses
MDOME	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
MDOME	GO:0004000	adenosine deaminase activity	Losses
MDOME	GO:0003777	microtubule motor activity	Losses
MDOME	GO:0005488	binding	Losses
MDOME	GO:0031490	chromatin DNA binding	Losses
MDOME	GO:0000257	nitrilase activity	Losses
MDOME	GO:0005504	fatty acid binding	Losses
MDOME	GO:0036440	citrate synthase activity	Losses
MDOME	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
MDOME	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
MDOME	GO:0000700	mismatch base pair DNA N-glycosylase activity	Losses
MDOME	GO:0070410	co-SMAD binding	Losses
MDOME	GO:0019841	retinol binding	Losses
MDOME	GO:0004362	glutathione-disulfide reductase activity	Losses
MDOME	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
MDOME	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
MDOME	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
MDOME	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
MDOME	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
MDOME	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Losses
MDOME	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
MDOME	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
MDOME	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
MDOME	GO:0005159	insulin-like growth factor receptor binding	Losses
MDOME	GO:0004164	diphthine synthase activity	Losses
MDOME	GO:0046332	SMAD binding	Losses
MDOME	GO:0004131	cytosine deaminase activity	Losses
MDOME	GO:0050111	mycocerosate synthase activity	Losses
MDOME	GO:0004108	citrate (Si)-synthase activity	Losses
MDOME	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
MDOME	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Losses
MDOME	GO:0004791	thioredoxin-disulfide reductase activity	Losses
MDOME	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
MDOME	GO:0003682	chromatin binding	Losses
MDOME	GO:0015038	glutathione disulfide oxidoreductase activity	Losses
MDOME	GO:0016531	copper chaperone activity	Losses
MDOME	GO:0003960	NADPH:quinone reductase activity	Losses
MDOME	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Losses
MDOME	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
MDOME	GO:0004033	aldo-keto reductase (NADP) activity	Losses
MDOME	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	Losses
MDOME	GO:0016420	malonyltransferase activity	Losses
MDOME	GO:0016419	S-malonyltransferase activity	Losses
MDOME	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Losses
MDOME	GO:0004328	formamidase activity	Losses
MDOME	GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
MDOME	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
MDOME	GO:0004333	fumarate hydratase activity	Losses
MDOME	GO:0033293	monocarboxylic acid binding	Losses
MDOME	GO:0043539	protein serine/threonine kinase activator activity	Losses
MDOME	GO:0015037	peptide disulfide oxidoreductase activity	Losses
MDOME	GO:1901363	heterocyclic compound binding	Losses
MDOME	GO:0097159	organic cyclic compound binding	Losses
MDOME	GO:0016787	hydrolase activity	Losses
MDOME	GO:0008236	serine-type peptidase activity	Losses
MDOME	GO:0017171	serine hydrolase activity	Losses
MDOME	GO:0016530	metallochaperone activity	Losses
MDOME	GO:0004830	tryptophan-tRNA ligase activity	Losses
MDOME	GO:0005501	retinoid binding	Losses
MDOME	GO:0019104	DNA N-glycosylase activity	Losses
MDOME	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
MDOME	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
MDOME	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
MDOME	GO:0016909	SAP kinase activity	Losses
MDOME	GO:0016418	S-acetyltransferase activity	Losses
MDOME	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
MDOME	GO:0005160	transforming growth factor beta receptor binding	Losses
MDOME	GO:0004484	mRNA guanylyltransferase activity	Losses
MDOME	GO:0004185	serine-type carboxypeptidase activity	Losses
MDOME	GO:0003677	DNA binding	Extinctions
MDOME	GO:0008301	DNA binding, bending	Extinctions
MDOME	GO:0008252	nucleotidase activity	Extinctions
MDOME	GO:0003700	DNA binding transcription factor activity	Extinctions
MDOME	GO:0140110	transcription regulator activity	Extinctions
MDOME	GO:0043565	sequence-specific DNA binding	Extinctions
MDOME	GO:0003676	nucleic acid binding	Extinctions
MDOME	GO:0005504	fatty acid binding	Extinctions
MDOME	GO:0000700	mismatch base pair DNA N-glycosylase activity	Extinctions
MDOME	GO:0019841	retinol binding	Extinctions
MDOME	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Extinctions
MDOME	GO:0005159	insulin-like growth factor receptor binding	Extinctions
MDOME	GO:0003690	double-stranded DNA binding	Extinctions
MDOME	GO:0016531	copper chaperone activity	Extinctions
MDOME	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	Extinctions
MDOME	GO:0033293	monocarboxylic acid binding	Extinctions
MDOME	GO:0005488	binding	Extinctions
MDOME	GO:0005507	copper ion binding	Extinctions
MDOME	GO:0004000	adenosine deaminase activity	Extinctions
MDOME	GO:0016530	metallochaperone activity	Extinctions
MDOME	GO:0005501	retinoid binding	Extinctions
MDOME	GO:0019104	DNA N-glycosylase activity	Extinctions
MDOME	GO:0005160	transforming growth factor beta receptor binding	Extinctions
MDOME	GO:0004484	mRNA guanylyltransferase activity	Extinctions
MDOME	GO:0003774	motor activity	Extinctions
MDOME	GO:1901363	heterocyclic compound binding	Extinctions
MDOME	GO:0050824	water binding	Extinctions
MDOME	GO:0050825	ice binding	Extinctions
MDOME	GO:0043178	alcohol binding	Extinctions
MDOME	GO:0008192	RNA guanylyltransferase activity	Extinctions
MDOME	GO:0005126	cytokine receptor binding	Extinctions
MDOME	GO:0043548	phosphatidylinositol 3-kinase binding	Extinctions
MDOME	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Extinctions
MDOME	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
MDOME	GO:0097159	organic cyclic compound binding	Extinctions
MDOME	GO:0005549	odorant binding	Extinctions
MDOME	GO:0004551	nucleotide diphosphatase activity	Extinctions
MDOME	GO:0019840	isoprenoid binding	Extinctions
MDOME	GO:0008253	5'-nucleotidase activity	Extinctions
MDOME	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
MDOME	GO:0019239	deaminase activity	Extinctions
LE3	GO:0004252	serine-type endopeptidase activity	Gains
LE3	GO:0008236	serine-type peptidase activity	Gains
LE3	GO:0017171	serine hydrolase activity	Gains
LE3	GO:0008233	peptidase activity	Gains
LE3	GO:0004175	endopeptidase activity	Gains
LE3	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
LE3	GO:0042302	structural constituent of cuticle	Gains
LE3	GO:0005549	odorant binding	Gains
LE3	GO:0004930	G-protein coupled receptor activity	Gains
LE3	GO:0004984	olfactory receptor activity	Gains
LE3	GO:0004888	transmembrane signaling receptor activity	Gains
LE3	GO:0099600	transmembrane receptor activity	Gains
LE3	GO:0038023	signaling receptor activity	Gains
LE3	GO:0030165	PDZ domain binding	Gains
LE3	GO:0008812	choline dehydrogenase activity	Gains
LE3	GO:0045505	dynein intermediate chain binding	Gains
LE3	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
LE3	GO:0005042	netrin receptor activity	Gains
LE3	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
LE3	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
LE3	GO:0004181	metallocarboxypeptidase activity	Gains
LE3	GO:0060089	molecular transducer activity	Gains
LE3	GO:0000340	RNA 7-methylguanosine cap binding	Gains
LE3	GO:0004872	receptor activity	Gains
LE3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
LE3	GO:0017110	nucleoside-diphosphatase activity	Gains
LE3	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	Gains
LE3	GO:0045134	uridine-diphosphatase activity	Gains
LE3	GO:0003824	catalytic activity	Losses
LE3	GO:0005215	transporter activity	Losses
LE3	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Losses
LE3	GO:0016740	transferase activity	Losses
LE3	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
LE3	GO:0030554	adenyl nucleotide binding	Losses
LE3	GO:0005524	ATP binding	Losses
LE3	GO:0032559	adenyl ribonucleotide binding	Losses
LE3	GO:0015144	carbohydrate transmembrane transporter activity	Losses
LE3	GO:0051119	sugar transmembrane transporter activity	Losses
LE3	GO:0043168	anion binding	Losses
LE3	GO:0140097	catalytic activity, acting on DNA	Losses
LE3	GO:0015295	solute:proton symporter activity	Losses
LE3	GO:0005351	sugar:proton symporter activity	Losses
LE3	GO:0005402	cation:sugar symporter activity	Losses
LE3	GO:0016779	nucleotidyltransferase activity	Losses
LE3	GO:0097367	carbohydrate derivative binding	Losses
LE3	GO:0015291	secondary active transmembrane transporter activity	Losses
LE3	GO:0015293	symporter activity	Losses
LE3	GO:0017076	purine nucleotide binding	Losses
LE3	GO:0036094	small molecule binding	Losses
LE3	GO:0022804	active transmembrane transporter activity	Losses
LE3	GO:0003725	double-stranded RNA binding	Losses
LE3	GO:0035639	purine ribonucleoside triphosphate binding	Losses
LE3	GO:0032555	purine ribonucleotide binding	Losses
LE3	GO:0032553	ribonucleotide binding	Losses
LE3	GO:0015294	solute:cation symporter activity	Losses
LE3	GO:0000156	phosphorelay response regulator activity	Losses
LE3	GO:0034061	DNA polymerase activity	Losses
LE3	GO:0019842	vitamin binding	Losses
LE3	GO:0022857	transmembrane transporter activity	Losses
LE3	GO:0016491	oxidoreductase activity	Losses
LE3	GO:0003964	RNA-directed DNA polymerase activity	Losses
LE3	GO:0008324	cation transmembrane transporter activity	Losses
LE3	GO:0017111	nucleoside-triphosphatase activity	Losses
LE3	GO:0016829	lyase activity	Losses
LE3	GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
LE3	GO:0016887	ATPase activity	Losses
LE3	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Losses
LE3	GO:0016787	hydrolase activity	Losses
LE3	GO:0015075	ion transmembrane transporter activity	Losses
LE3	GO:0016462	pyrophosphatase activity	Losses
LE3	GO:0004518	nuclease activity	Losses
LE3	GO:0016849	phosphorus-oxygen lyase activity	Losses
LE3	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Losses
LE3	GO:0022892	substrate-specific transporter activity	Losses
LE3	GO:1901265	nucleoside phosphate binding	Losses
LE3	GO:0000166	nucleotide binding	Losses
LE3	GO:0016817	hydrolase activity, acting on acid anhydrides	Losses
LE3	GO:0005245	voltage-gated calcium channel activity	Losses
LE3	GO:0004525	ribonuclease III activity	Losses
LE3	GO:0032296	double-stranded RNA-specific ribonuclease activity	Losses
LE3	GO:0005343	organic acid:sodium symporter activity	Losses
LE3	GO:0030170	pyridoxal phosphate binding	Losses
LE3	GO:0070279	vitamin B6 binding	Losses
LE3	GO:0003700	DNA binding transcription factor activity	Losses
LE3	GO:0004519	endonuclease activity	Losses
LE3	GO:0048037	cofactor binding	Losses
LE3	GO:0004565	beta-galactosidase activity	Losses
LE3	GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
LE3	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
LE3	GO:0005262	calcium channel activity	Losses
LE3	GO:0046873	metal ion transmembrane transporter activity	Losses
LE3	GO:0015085	calcium ion transmembrane transporter activity	Losses
LE3	GO:0046914	transition metal ion binding	Losses
LE3	GO:0051213	dioxygenase activity	Losses
LE3	GO:0003993	acid phosphatase activity	Losses
LE3	GO:0043167	ion binding	Losses
LE3	GO:0022891	substrate-specific transmembrane transporter activity	Losses
LE3	GO:0015297	antiporter activity	Losses
LE3	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
LE3	GO:0008514	organic anion transmembrane transporter activity	Losses
LE3	GO:0034483	heparan sulfate sulfotransferase activity	Losses
LE3	GO:0015925	galactosidase activity	Losses
LE3	GO:0008509	anion transmembrane transporter activity	Losses
LE3	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
LE3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Losses
LE3	GO:0099516	ion antiporter activity	Losses
LE3	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
LE3	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
LE3	GO:0070001	aspartic-type peptidase activity	Losses
LE3	GO:0004190	aspartic-type endopeptidase activity	Losses
LE3	GO:0016763	transferase activity, transferring pentosyl groups	Losses
LE3	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
LE3	GO:0005548	phospholipid transporter activity	Losses
LE3	GO:0008519	ammonium transmembrane transporter activity	Losses
LE3	GO:0017153	sodium:dicarboxylate symporter activity	Losses
LE3	GO:0004012	phospholipid-translocating ATPase activity	Losses
LE3	GO:0008270	zinc ion binding	Losses
LE3	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
LE3	GO:0031406	carboxylic acid binding	Losses
LE3	GO:0043177	organic acid binding	Losses
LE3	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Extinctions
LE3	GO:0005215	transporter activity	Extinctions
LE3	GO:0015295	solute:proton symporter activity	Extinctions
LE3	GO:0005351	sugar:proton symporter activity	Extinctions
LE3	GO:0005402	cation:sugar symporter activity	Extinctions
LE3	GO:0015144	carbohydrate transmembrane transporter activity	Extinctions
LE3	GO:0051119	sugar transmembrane transporter activity	Extinctions
LE3	GO:0015294	solute:cation symporter activity	Extinctions
LE3	GO:0003824	catalytic activity	Extinctions
LE3	GO:0016829	lyase activity	Extinctions
LE3	GO:0015293	symporter activity	Extinctions
LE3	GO:0000156	phosphorelay response regulator activity	Extinctions
LE3	GO:0015291	secondary active transmembrane transporter activity	Extinctions
LE3	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
LE3	GO:0000155	phosphorelay sensor kinase activity	Extinctions
LE3	GO:0004673	protein histidine kinase activity	Extinctions
LE3	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Extinctions
LE3	GO:0016763	transferase activity, transferring pentosyl groups	Extinctions
LE3	GO:0022804	active transmembrane transporter activity	Extinctions
LE3	GO:0016887	ATPase activity	Extinctions
LE3	GO:0017153	sodium:dicarboxylate symporter activity	Extinctions
LE3	GO:0016491	oxidoreductase activity	Extinctions
LE3	GO:0003700	DNA binding transcription factor activity	Extinctions
LE3	GO:0030976	thiamine pyrophosphate binding	Extinctions
LE3	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Extinctions
LE3	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Extinctions
LE3	GO:0017111	nucleoside-triphosphatase activity	Extinctions
LE3	GO:0005343	organic acid:sodium symporter activity	Extinctions
LE3	GO:0140097	catalytic activity, acting on DNA	Extinctions
LE3	GO:0140104	molecular carrier activity	Extinctions
LE3	GO:0016462	pyrophosphatase activity	Extinctions
LE3	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Extinctions
LE3	GO:0016817	hydrolase activity, acting on acid anhydrides	Extinctions
LE3	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
LE3	GO:0015296	anion:cation symporter activity	Extinctions
LE3	GO:0050662	coenzyme binding	Extinctions
LE3	GO:0004107	chorismate synthase activity	Extinctions
LE3	GO:0008861	formate C-acetyltransferase activity	Extinctions
LE3	GO:0015665	alcohol transmembrane transporter activity	Extinctions
LE3	GO:0042925	benzoate transmembrane transporter activity	Extinctions
LE3	GO:0008811	chloramphenicol O-acetyltransferase activity	Extinctions
LE3	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Extinctions
LE3	GO:0033862	UMP kinase activity	Extinctions
LE3	GO:0008690	3-deoxy-manno-octulosonate cytidylyltransferase activity	Extinctions
LE3	GO:0000234	phosphoethanolamine N-methyltransferase activity	Extinctions
LE3	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Extinctions
LE3	GO:0043914	NADPH:sulfur oxidoreductase activity	Extinctions
LE3	GO:0008964	phosphoenolpyruvate carboxylase activity	Extinctions
LE3	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	Extinctions
LE3	GO:0008974	phosphoribulokinase activity	Extinctions
LE3	GO:0008976	polyphosphate kinase activity	Extinctions
LE3	GO:0008922	long-chain fatty acid [acyl-carrier-protein] ligase activity	Extinctions
LE3	GO:0052657	guanine phosphoribosyltransferase activity	Extinctions
LE3	GO:0009381	excinuclease ABC activity	Extinctions
LE3	GO:0016987	sigma factor activity	Extinctions
LE3	GO:0030743	rRNA (adenosine-2'-O-)-methyltransferase activity	Extinctions
LE3	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Extinctions
LE3	GO:0015166	polyol transmembrane transporter activity	Extinctions
LE3	GO:0000990	transcription factor activity, core RNA polymerase binding	Extinctions
LE3	GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity	Extinctions
LE3	GO:0004397	histidine ammonia-lyase activity	Extinctions
LE3	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
LE3	GO:0034986	iron chaperone activity	Extinctions
LE3	GO:0004455	ketol-acid reductoisomerase activity	Extinctions
LE3	GO:0004422	hypoxanthine phosphoribosyltransferase activity	Extinctions
LE3	GO:0045148	tripeptide aminopeptidase activity	Extinctions
LE3	GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	Extinctions
LE3	GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	Extinctions
LE3	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	Extinctions
LE3	GO:0015577	galactitol transmembrane transporter activity	Extinctions
LE3	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
LE3	GO:0048037	cofactor binding	Extinctions
LE3	GO:0008514	organic anion transmembrane transporter activity	Extinctions
LE3	GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
LE3	GO:0022857	transmembrane transporter activity	Extinctions
LE3	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
LE3	GO:0005310	dicarboxylic acid transmembrane transporter activity	Extinctions
LE3	GO:0034061	DNA polymerase activity	Extinctions
LE3	GO:0008324	cation transmembrane transporter activity	Extinctions
LE3	GO:0016779	nucleotidyltransferase activity	Extinctions
LE3	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Extinctions
LE3	GO:0050661	NADP binding	Extinctions
BTERR	GO:0003964	RNA-directed DNA polymerase activity	Gains
BTERR	GO:0034061	DNA polymerase activity	Gains
BTERR	GO:0004984	olfactory receptor activity	Gains
BTERR	GO:0005549	odorant binding	Gains
BTERR	GO:0004190	aspartic-type endopeptidase activity	Gains
BTERR	GO:0070001	aspartic-type peptidase activity	Gains
BTERR	GO:0008270	zinc ion binding	Gains
BTERR	GO:0046914	transition metal ion binding	Gains
BTERR	GO:0038023	signaling receptor activity	Gains
BTERR	GO:0043169	cation binding	Gains
BTERR	GO:0140097	catalytic activity, acting on DNA	Gains
BTERR	GO:0016779	nucleotidyltransferase activity	Gains
BTERR	GO:0046872	metal ion binding	Gains
BTERR	GO:0004872	receptor activity	Gains
BTERR	GO:0008527	taste receptor activity	Gains
BTERR	GO:0003676	nucleic acid binding	Gains
BTERR	GO:0004930	G-protein coupled receptor activity	Gains
BTERR	GO:0060089	molecular transducer activity	Gains
BTERR	GO:0004871	signal transducer activity	Gains
BTERR	GO:0008233	peptidase activity	Gains
BTERR	GO:0004888	transmembrane signaling receptor activity	Gains
BTERR	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
BTERR	GO:0099600	transmembrane receptor activity	Gains
BTERR	GO:0005488	binding	Gains
BTERR	GO:0008238	exopeptidase activity	Gains
BTERR	GO:0004175	endopeptidase activity	Gains
BTERR	GO:0004180	carboxypeptidase activity	Gains
BTERR	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
BTERR	GO:0042169	SH2 domain binding	Gains
BTERR	GO:1901363	heterocyclic compound binding	Gains
BTERR	GO:0003677	DNA binding	Gains
BTERR	GO:0097159	organic cyclic compound binding	Gains
BTERR	GO:0008235	metalloexopeptidase activity	Gains
BTERR	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
BTERR	GO:0004629	phospholipase C activity	Gains
BTERR	GO:0016405	CoA-ligase activity	Gains
BTERR	GO:0000155	phosphorelay sensor kinase activity	Gains
BTERR	GO:0042562	hormone binding	Gains
BTERR	GO:0004673	protein histidine kinase activity	Gains
BTERR	GO:0043167	ion binding	Gains
BTERR	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
BTERR	GO:0004866	endopeptidase inhibitor activity	Gains
BTERR	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
BTERR	GO:0016878	acid-thiol ligase activity	Gains
BTERR	GO:0004181	metallocarboxypeptidase activity	Gains
BTERR	GO:0016208	AMP binding	Gains
BTERR	GO:0043560	insulin receptor substrate binding	Gains
BTERR	GO:0043559	insulin binding	Gains
BTERR	GO:0008251	tRNA-specific adenosine deaminase activity	Gains
BTERR	GO:0005104	fibroblast growth factor receptor binding	Gains
BTERR	GO:0004321	fatty-acyl-CoA synthase activity	Gains
BTERR	GO:0003720	telomerase activity	Gains
BTERR	GO:0003721	telomerase RNA reverse transcriptase activity	Gains
BTERR	GO:0008741	ribulokinase activity	Gains
BTERR	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	Gains
BTERR	GO:0005550	pheromone binding	Gains
BTERR	GO:0070615	nucleosome-dependent ATPase activity	Gains
BTERR	GO:0051425	PTB domain binding	Gains
BTERR	GO:0005009	insulin-activated receptor activity	Gains
BTERR	GO:0008061	chitin binding	Gains
BTERR	GO:0061135	endopeptidase regulator activity	Gains
BTERR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
BTERR	GO:0005201	extracellular matrix structural constituent	Gains
BTERR	GO:0030414	peptidase inhibitor activity	Gains
BTERR	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
BTERR	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
BTERR	GO:0004033	aldo-keto reductase (NADP) activity	Gains
BTERR	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
BTERR	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
BTERR	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
BTERR	GO:0004371	glycerone kinase activity	Gains
BTERR	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Gains
BTERR	GO:0004463	leukotriene-A4 hydrolase activity	Gains
BTERR	GO:0004470	malic enzyme activity	Gains
BTERR	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
BTERR	GO:0052723	inositol hexakisphosphate 1-kinase activity	Gains
BTERR	GO:0052724	inositol hexakisphosphate 3-kinase activity	Gains
BTERR	GO:0005520	insulin-like growth factor binding	Gains
BTERR	GO:0019788	NEDD8 transferase activity	Gains
BTERR	GO:0022833	mechanically gated channel activity	Gains
BTERR	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
BTERR	GO:0003997	acyl-CoA oxidase activity	Gains
BTERR	GO:0003987	acetate-CoA ligase activity	Gains
BTERR	GO:0005080	protein kinase C binding	Gains
BTERR	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Gains
BTERR	GO:0000828	inositol hexakisphosphate kinase activity	Gains
BTERR	GO:0000832	inositol hexakisphosphate 5-kinase activity	Gains
BTERR	GO:0008381	mechanically-gated ion channel activity	Gains
BTERR	GO:0032033	myosin II light chain binding	Gains
BTERR	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
BTERR	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
BTERR	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
BTERR	GO:0042302	structural constituent of cuticle	Losses
BTERR	GO:0003700	DNA binding transcription factor activity	Losses
BTERR	GO:0004736	pyruvate carboxylase activity	Losses
BTERR	GO:0005024	transforming growth factor beta-activated receptor activity	Losses
BTERR	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Losses
BTERR	GO:0016418	S-acetyltransferase activity	Losses
BTERR	GO:0043565	sequence-specific DNA binding	Losses
BTERR	GO:0005214	structural constituent of chitin-based cuticle	Losses
BTERR	GO:0008241	peptidyl-dipeptidase activity	Losses
BTERR	GO:0004075	biotin carboxylase activity	Losses
BTERR	GO:0140110	transcription regulator activity	Losses
BTERR	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Losses
BTERR	GO:0004879	nuclear receptor activity	Losses
BTERR	GO:0016840	carbon-nitrogen lyase activity	Losses
BTERR	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
BTERR	GO:0003707	steroid hormone receptor activity	Losses
BTERR	GO:0003677	DNA binding	Losses
BTERR	GO:0044212	transcription regulatory region DNA binding	Losses
BTERR	GO:0001067	regulatory region nucleic acid binding	Losses
BTERR	GO:0000975	regulatory region DNA binding	Losses
BTERR	GO:0004803	transposase activity	Losses
BTERR	GO:0008134	transcription factor binding	Losses
BTERR	GO:0004000	adenosine deaminase activity	Losses
BTERR	GO:0044877	macromolecular complex binding	Losses
BTERR	GO:0004872	receptor activity	Losses
BTERR	GO:0032403	protein complex binding	Losses
BTERR	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
BTERR	GO:0038023	signaling receptor activity	Losses
BTERR	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
BTERR	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
BTERR	GO:0050431	transforming growth factor beta binding	Losses
BTERR	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
BTERR	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
BTERR	GO:0004946	bombesin receptor activity	Losses
BTERR	GO:0050111	mycocerosate synthase activity	Losses
BTERR	GO:0009703	nitrate reductase (NADH) activity	Losses
BTERR	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
BTERR	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
BTERR	GO:0005125	cytokine activity	Losses
BTERR	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Losses
BTERR	GO:0008255	ecdysis-triggering hormone activity	Losses
BTERR	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
BTERR	GO:0004329	formate-tetrahydrofolate ligase activity	Losses
BTERR	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
BTERR	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
BTERR	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
BTERR	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
BTERR	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
BTERR	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
BTERR	GO:0005222	intracellular cAMP activated cation channel activity	Losses
BTERR	GO:0005223	intracellular cGMP activated cation channel activity	Losses
BTERR	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Losses
BTERR	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Losses
BTERR	GO:0042301	phosphate ion binding	Losses
BTERR	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Losses
BTERR	GO:0003873	6-phosphofructo-2-kinase activity	Losses
BTERR	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
BTERR	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
BTERR	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
BTERR	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
BTERR	GO:0004796	thromboxane-A synthase activity	Losses
BTERR	GO:0001222	transcription corepressor binding	Losses
BTERR	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
BTERR	GO:0050093	methanol dehydrogenase activity	Losses
BTERR	GO:0047880	erythrulose reductase activity	Losses
BTERR	GO:0000257	nitrilase activity	Losses
BTERR	GO:0016361	activin receptor activity, type I	Losses
BTERR	GO:0005025	transforming growth factor beta receptor activity, type I	Losses
BTERR	GO:0008940	nitrate reductase activity	Losses
BTERR	GO:0070037	rRNA (pseudouridine) methyltransferase activity	Losses
BTERR	GO:0047536	2-aminoadipate transaminase activity	Losses
BTERR	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
BTERR	GO:0004055	argininosuccinate synthase activity	Losses
BTERR	GO:0004056	argininosuccinate lyase activity	Losses
BTERR	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
BTERR	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
BTERR	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
BTERR	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Losses
BTERR	GO:1990837	sequence-specific double-stranded DNA binding	Losses
BTERR	GO:0008528	G-protein coupled peptide receptor activity	Losses
BTERR	GO:0001653	peptide receptor activity	Losses
BTERR	GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
BTERR	GO:0060089	molecular transducer activity	Losses
BTERR	GO:0004871	signal transducer activity	Losses
BTERR	GO:0004312	fatty acid synthase activity	Losses
BTERR	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
BTERR	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
BTERR	GO:0019199	transmembrane receptor protein kinase activity	Losses
BTERR	GO:0008227	G-protein coupled amine receptor activity	Losses
BTERR	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
BTERR	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
BTERR	GO:0004033	aldo-keto reductase (NADP) activity	Losses
BTERR	GO:0043874	acireductone synthase activity	Losses
BTERR	GO:0008443	phosphofructokinase activity	Losses
BTERR	GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
BTERR	GO:0016843	amine-lyase activity	Losses
BTERR	GO:0016844	strictosidine synthase activity	Losses
BTERR	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
BTERR	GO:0004370	glycerol kinase activity	Losses
BTERR	GO:0004328	formamidase activity	Losses
BTERR	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
BTERR	GO:0050591	quinine 3-monooxygenase activity	Losses
BTERR	GO:0001221	transcription cofactor binding	Losses
BTERR	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
BTERR	GO:0005500	juvenile hormone binding	Losses
BTERR	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	Losses
BTERR	GO:0030553	cGMP binding	Losses
BTERR	GO:0030523	dihydrolipoamide S-acyltransferase activity	Losses
BTERR	GO:0004884	ecdysteroid hormone receptor activity	Losses
BTERR	GO:0004821	histidine-tRNA ligase activity	Losses
BTERR	GO:0000146	microfilament motor activity	Losses
BTERR	GO:0004686	elongation factor-2 kinase activity	Losses
BTERR	GO:0048185	activin binding	Losses
BTERR	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
BTERR	GO:0016420	malonyltransferase activity	Losses
BTERR	GO:0016419	S-malonyltransferase activity	Losses
BTERR	GO:0017002	activin-activated receptor activity	Losses
BTERR	GO:0050308	sugar-phosphatase activity	Losses
BTERR	GO:0018685	alkane 1-monooxygenase activity	Losses
BTERR	GO:0019239	deaminase activity	Losses
BTERR	GO:0003690	double-stranded DNA binding	Losses
BTERR	GO:0016417	S-acyltransferase activity	Losses
BTERR	GO:0004736	pyruvate carboxylase activity	Extinctions
BTERR	GO:0004075	biotin carboxylase activity	Extinctions
BTERR	GO:0016840	carbon-nitrogen lyase activity	Extinctions
BTERR	GO:0042302	structural constituent of cuticle	Extinctions
BTERR	GO:0016885	ligase activity, forming carbon-carbon bonds	Extinctions
BTERR	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Extinctions
BTERR	GO:0008255	ecdysis-triggering hormone activity	Extinctions
BTERR	GO:0047880	erythrulose reductase activity	Extinctions
BTERR	GO:0000257	nitrilase activity	Extinctions
BTERR	GO:0070037	rRNA (pseudouridine) methyltransferase activity	Extinctions
BTERR	GO:0004055	argininosuccinate synthase activity	Extinctions
BTERR	GO:0004056	argininosuccinate lyase activity	Extinctions
BTERR	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Extinctions
BTERR	GO:0003743	translation initiation factor activity	Extinctions
BTERR	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Extinctions
BTERR	GO:0004879	nuclear receptor activity	Extinctions
BTERR	GO:0003707	steroid hormone receptor activity	Extinctions
BTERR	GO:0016843	amine-lyase activity	Extinctions
BTERR	GO:0016844	strictosidine synthase activity	Extinctions
BTERR	GO:0004328	formamidase activity	Extinctions
BTERR	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	Extinctions
BTERR	GO:0030523	dihydrolipoamide S-acyltransferase activity	Extinctions
BTERR	GO:0004821	histidine-tRNA ligase activity	Extinctions
BTERR	GO:0000146	microfilament motor activity	Extinctions
BTERR	GO:0004686	elongation factor-2 kinase activity	Extinctions
BTERR	GO:0003676	nucleic acid binding	Extinctions
BTERR	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
BTERR	GO:0016842	amidine-lyase activity	Extinctions
BTERR	GO:0016418	S-acetyltransferase activity	Extinctions
BTERR	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
BTERR	GO:0016874	ligase activity	Extinctions
BTERR	GO:0002039	p53 binding	Extinctions
BTERR	GO:0008135	translation factor activity, RNA binding	Extinctions
DGRIM	GO:0004984	olfactory receptor activity	Gains
DGRIM	GO:0005549	odorant binding	Gains
DGRIM	GO:0004930	G-protein coupled receptor activity	Gains
DGRIM	GO:0008135	translation factor activity, RNA binding	Gains
DGRIM	GO:0003743	translation initiation factor activity	Gains
DGRIM	GO:0004887	thyroid hormone receptor activity	Gains
DGRIM	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
DGRIM	GO:0004751	ribose-5-phosphate isomerase activity	Gains
DGRIM	GO:0050591	quinine 3-monooxygenase activity	Gains
DGRIM	GO:0004821	histidine-tRNA ligase activity	Gains
DGRIM	GO:0052716	hydroquinone:oxygen oxidoreductase activity	Gains
DGRIM	GO:0003997	acyl-CoA oxidase activity	Gains
DGRIM	GO:0008234	cysteine-type peptidase activity	Gains
DGRIM	GO:0070851	growth factor receptor binding	Gains
DGRIM	GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
DGRIM	GO:0004619	phosphoglycerate mutase activity	Gains
DGRIM	GO:0099600	transmembrane receptor activity	Gains
DGRIM	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Gains
DGRIM	GO:0008447	L-ascorbate oxidase activity	Gains
DGRIM	GO:0016418	S-acetyltransferase activity	Gains
DGRIM	GO:0060089	molecular transducer activity	Gains
DGRIM	GO:0004888	transmembrane signaling receptor activity	Gains
DGRIM	GO:0004872	receptor activity	Gains
DGRIM	GO:0015081	sodium ion transmembrane transporter activity	Gains
DGRIM	GO:0043021	ribonucleoprotein complex binding	Gains
DGRIM	GO:0038023	signaling receptor activity	Gains
DGRIM	GO:0004089	carbonate dehydratase activity	Gains
DGRIM	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
DGRIM	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
DGRIM	GO:0070330	aromatase activity	Gains
DGRIM	GO:0043022	ribosome binding	Gains
DGRIM	GO:0031624	ubiquitin conjugating enzyme binding	Gains
DGRIM	GO:0044390	ubiquitin-like protein conjugating enzyme binding	Gains
DGRIM	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
DGRIM	GO:0061659	ubiquitin-like protein ligase activity	Gains
DGRIM	GO:0061630	ubiquitin protein ligase activity	Gains
DGRIM	GO:0004745	retinol dehydrogenase activity	Gains
DGRIM	GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
DGRIM	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
DGRIM	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
DGRIM	GO:0046030	inositol trisphosphate phosphatase activity	Losses
DGRIM	GO:0008270	zinc ion binding	Losses
DGRIM	GO:0052745	inositol phosphate phosphatase activity	Losses
DGRIM	GO:0046914	transition metal ion binding	Losses
DGRIM	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	Losses
DGRIM	GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	Losses
DGRIM	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Losses
DGRIM	GO:0004445	inositol-polyphosphate 5-phosphatase activity	Losses
DGRIM	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Losses
DGRIM	GO:0052743	inositol tetrakisphosphate phosphatase activity	Losses
DGRIM	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	Losses
DGRIM	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	Losses
DGRIM	GO:0004535	poly(A)-specific ribonuclease activity	Losses
DGRIM	GO:0000175	3'-5'-exoribonuclease activity	Losses
DGRIM	GO:0052866	phosphatidylinositol phosphate phosphatase activity	Losses
DGRIM	GO:0008408	3'-5' exonuclease activity	Losses
DGRIM	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Losses
DGRIM	GO:0004532	exoribonuclease activity	Losses
DGRIM	GO:0004540	ribonuclease activity	Losses
DGRIM	GO:0032182	ubiquitin-like protein binding	Losses
DGRIM	GO:0046872	metal ion binding	Losses
DGRIM	GO:0043169	cation binding	Losses
DGRIM	GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
DGRIM	GO:0003676	nucleic acid binding	Losses
DGRIM	GO:0004527	exonuclease activity	Losses
DGRIM	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Losses
DGRIM	GO:0032183	SUMO binding	Losses
DGRIM	GO:0008115	sarcosine oxidase activity	Losses
DGRIM	GO:0047598	7-dehydrocholesterol reductase activity	Losses
DGRIM	GO:0030628	pre-mRNA 3'-splice site binding	Losses
DGRIM	GO:0016160	amylase activity	Losses
DGRIM	GO:0070976	TIR domain binding	Losses
DGRIM	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
DGRIM	GO:0042979	ornithine decarboxylase regulator activity	Losses
DGRIM	GO:0008515	sucrose transmembrane transporter activity	Losses
DGRIM	GO:0097493	structural molecule activity conferring elasticity	Losses
DGRIM	GO:0001222	transcription corepressor binding	Losses
DGRIM	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
DGRIM	GO:0005521	lamin binding	Losses
DGRIM	GO:0005534	galactose binding	Losses
DGRIM	GO:0030350	iron-responsive element binding	Losses
DGRIM	GO:0015026	coreceptor activity	Losses
DGRIM	GO:0004556	alpha-amylase activity	Losses
DGRIM	GO:0050613	delta14-sterol reductase activity	Losses
DGRIM	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
DGRIM	GO:0004518	nuclease activity	Losses
DGRIM	GO:0016787	hydrolase activity	Losses
DGRIM	GO:0016788	hydrolase activity, acting on ester bonds	Losses
DGRIM	GO:0008568	microtubule-severing ATPase activity	Losses
DGRIM	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
DGRIM	GO:0070888	E-box binding	Losses
DGRIM	GO:0008379	thioredoxin peroxidase activity	Losses
DGRIM	GO:0015154	disaccharide transmembrane transporter activity	Losses
DGRIM	GO:0015157	oligosaccharide transmembrane transporter activity	Losses
DGRIM	GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
DGRIM	GO:0070628	proteasome binding	Losses
DGRIM	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
DGRIM	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Losses
DGRIM	GO:0004416	hydroxyacylglutathione hydrolase activity	Losses
DGRIM	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
DGRIM	GO:0008897	holo-[acyl-carrier-protein] synthase activity	Losses
DGRIM	GO:0004753	saccharopine dehydrogenase activity	Losses
DGRIM	GO:0001221	transcription cofactor binding	Losses
DGRIM	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
DGRIM	GO:0003994	aconitate hydratase activity	Losses
DGRIM	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
DGRIM	GO:0016791	phosphatase activity	Losses
DGRIM	GO:0003723	RNA binding	Losses
DGRIM	GO:0051010	microtubule plus-end binding	Losses
DGRIM	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
DGRIM	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Losses
DGRIM	GO:0043138	3'-5' DNA helicase activity	Losses
DGRIM	GO:0005432	calcium:sodium antiporter activity	Losses
DGRIM	GO:0017056	structural constituent of nuclear pore	Losses
DGRIM	GO:0004144	diacylglycerol O-acyltransferase activity	Losses
DGRIM	GO:0001103	RNA polymerase II repressing transcription factor binding	Losses
DGRIM	GO:0008097	5S rRNA binding	Losses
DGRIM	GO:0046030	inositol trisphosphate phosphatase activity	Extinctions
DGRIM	GO:0008270	zinc ion binding	Extinctions
DGRIM	GO:0046914	transition metal ion binding	Extinctions
DGRIM	GO:0052745	inositol phosphate phosphatase activity	Extinctions
DGRIM	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	Extinctions
DGRIM	GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	Extinctions
DGRIM	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Extinctions
DGRIM	GO:0004445	inositol-polyphosphate 5-phosphatase activity	Extinctions
DGRIM	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Extinctions
DGRIM	GO:0052743	inositol tetrakisphosphate phosphatase activity	Extinctions
DGRIM	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	Extinctions
DGRIM	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	Extinctions
DGRIM	GO:0004535	poly(A)-specific ribonuclease activity	Extinctions
DGRIM	GO:0000175	3'-5'-exoribonuclease activity	Extinctions
DGRIM	GO:0052866	phosphatidylinositol phosphate phosphatase activity	Extinctions
DGRIM	GO:0004540	ribonuclease activity	Extinctions
DGRIM	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
DGRIM	GO:0004532	exoribonuclease activity	Extinctions
DGRIM	GO:0046872	metal ion binding	Extinctions
DGRIM	GO:0043169	cation binding	Extinctions
DGRIM	GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
DGRIM	GO:0008408	3'-5' exonuclease activity	Extinctions
DGRIM	GO:0003676	nucleic acid binding	Extinctions
DGRIM	GO:0047598	7-dehydrocholesterol reductase activity	Extinctions
DGRIM	GO:0030628	pre-mRNA 3'-splice site binding	Extinctions
DGRIM	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
DGRIM	GO:0005521	lamin binding	Extinctions
DGRIM	GO:0050613	delta14-sterol reductase activity	Extinctions
DGRIM	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
DGRIM	GO:0008568	microtubule-severing ATPase activity	Extinctions
DGRIM	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
DGRIM	GO:0004518	nuclease activity	Extinctions
DGRIM	GO:0005549	odorant binding	Extinctions
DGRIM	GO:0016791	phosphatase activity	Extinctions
DGRIM	GO:0008475	procollagen-lysine 5-dioxygenase activity	Extinctions
DGRIM	GO:0070628	proteasome binding	Extinctions
DGRIM	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Extinctions
DGRIM	GO:0008897	holo-[acyl-carrier-protein] synthase activity	Extinctions
DGRIM	GO:0004527	exonuclease activity	Extinctions
DGRIM	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DGRIM	GO:0016787	hydrolase activity	Extinctions
DGRIM	GO:0042578	phosphoric ester hydrolase activity	Extinctions
DGRIM	GO:0051010	microtubule plus-end binding	Extinctions
DGRIM	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Extinctions
DGRIM	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Extinctions
DGRIM	GO:0043138	3'-5' DNA helicase activity	Extinctions
DGRIM	GO:0017056	structural constituent of nuclear pore	Extinctions
DGRIM	GO:0008097	5S rRNA binding	Extinctions
DGRIM	GO:0003723	RNA binding	Extinctions
DGRIM	GO:0043130	ubiquitin binding	Extinctions
DGRIM	GO:0005487	nucleocytoplasmic transporter activity	Extinctions
DGRIM	GO:0036002	pre-mRNA binding	Extinctions
DGRIM	GO:0008519	ammonium transmembrane transporter activity	Extinctions
DGRIM	GO:0043167	ion binding	Extinctions
LE5	GO:0005213	structural constituent of chorion	Gains
LE5	GO:0008233	peptidase activity	Gains
LE5	GO:0005125	cytokine activity	Gains
LE5	GO:0005104	fibroblast growth factor receptor binding	Gains
LE5	GO:0034185	apolipoprotein binding	Gains
LE5	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Gains
LE5	GO:0008801	beta-phosphoglucomutase activity	Gains
LE5	GO:0050221	prostaglandin-E2 9-reductase activity	Gains
LE5	GO:0001587	Gq/11-coupled serotonin receptor activity	Gains
LE5	GO:0097109	neuroligin family protein binding	Gains
LE5	GO:0052813	phosphatidylinositol bisphosphate kinase activity	Gains
LE5	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Gains
LE5	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Gains
LE5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
LE5	GO:0004311	farnesyltranstransferase activity	Gains
LE5	GO:0004337	geranyltranstransferase activity	Gains
LE5	GO:0051371	muscle alpha-actinin binding	Gains
LE5	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
LE5	GO:0001727	lipid kinase activity	Gains
LE5	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Gains
LE5	GO:0005200	structural constituent of cytoskeleton	Gains
LE5	GO:0051393	alpha-actinin binding	Gains
LE5	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
LE5	GO:0016303	1-phosphatidylinositol-3-kinase activity	Gains
LE5	GO:0004161	dimethylallyltranstransferase activity	Gains
LE5	GO:0008853	exodeoxyribonuclease III activity	Gains
LE5	GO:0004090	carbonyl reductase (NADPH) activity	Gains
LE5	GO:0004035	alkaline phosphatase activity	Gains
LE5	GO:0042805	actinin binding	Gains
LE5	GO:0004252	serine-type endopeptidase activity	Gains
LE5	GO:0070001	aspartic-type peptidase activity	Losses
LE5	GO:0004190	aspartic-type endopeptidase activity	Losses
LE5	GO:0015103	inorganic anion transmembrane transporter activity	Losses
LE5	GO:0015081	sodium ion transmembrane transporter activity	Losses
LE5	GO:0003964	RNA-directed DNA polymerase activity	Losses
LE5	GO:0016491	oxidoreductase activity	Losses
LE5	GO:0008509	anion transmembrane transporter activity	Losses
LE5	GO:0015296	anion:cation symporter activity	Losses
LE5	GO:0022804	active transmembrane transporter activity	Losses
LE5	GO:0015291	secondary active transmembrane transporter activity	Losses
LE5	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
LE5	GO:0008484	sulfuric ester hydrolase activity	Losses
LE5	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
LE5	GO:0004364	glutathione transferase activity	Losses
LE5	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
LE5	GO:0034062	5'-3' RNA polymerase activity	Losses
LE5	GO:0097747	RNA polymerase activity	Losses
LE5	GO:0005272	sodium channel activity	Losses
LE5	GO:0034061	DNA polymerase activity	Losses
LE5	GO:0016209	antioxidant activity	Losses
LE5	GO:0016779	nucleotidyltransferase activity	Losses
LE5	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Losses
LE5	GO:0004321	fatty-acyl-CoA synthase activity	Losses
LE5	GO:0018833	DDT-dehydrochlorinase activity	Losses
LE5	GO:0047964	glyoxylate reductase activity	Losses
LE5	GO:0016155	formyltetrahydrofolate dehydrogenase activity	Losses
LE5	GO:0008511	sodium:potassium:chloride symporter activity	Losses
LE5	GO:0005504	fatty acid binding	Losses
LE5	GO:0004734	pyrimidodiazepine synthase activity	Losses
LE5	GO:0030267	glyoxylate reductase (NADP) activity	Losses
LE5	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
LE5	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
LE5	GO:0004666	prostaglandin-endoperoxide synthase activity	Losses
LE5	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Losses
LE5	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Losses
LE5	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
LE5	GO:0004060	arylamine N-acetyltransferase activity	Losses
LE5	GO:0004059	aralkylamine N-acetyltransferase activity	Losses
LE5	GO:0008459	chondroitin 6-sulfotransferase activity	Losses
LE5	GO:0005436	sodium:phosphate symporter activity	Losses
LE5	GO:0019841	retinol binding	Losses
LE5	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Losses
LE5	GO:0005215	transporter activity	Losses
LE5	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
LE5	GO:0022857	transmembrane transporter activity	Losses
LE5	GO:0015108	chloride transmembrane transporter activity	Losses
LE5	GO:0022892	substrate-specific transporter activity	Losses
LE5	GO:0015075	ion transmembrane transporter activity	Losses
LE5	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
LE5	GO:0008812	choline dehydrogenase activity	Losses
LE5	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
LE5	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Losses
LE5	GO:0004337	geranyltranstransferase activity	Losses
LE5	GO:0034481	chondroitin sulfotransferase activity	Losses
LE5	GO:0015203	polyamine transmembrane transporter activity	Losses
LE5	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
LE5	GO:0032050	clathrin heavy chain binding	Losses
LE5	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Losses
LE5	GO:0004890	GABA-A receptor activity	Losses
LE5	GO:0004560	alpha-L-fucosidase activity	Losses
LE5	GO:0016848	carbon-halide lyase activity	Losses
LE5	GO:0015037	peptide disulfide oxidoreductase activity	Losses
LE5	GO:0015038	glutathione disulfide oxidoreductase activity	Losses
LE5	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Losses
LE5	GO:0015928	fucosidase activity	Losses
LE5	GO:0004046	aminoacylase activity	Losses
LE5	GO:0015377	cation:chloride symporter activity	Losses
LE5	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Losses
LE5	GO:0005314	high-affinity glutamate transmembrane transporter activity	Losses
LE5	GO:0015417	polyamine-transporting ATPase activity	Losses
LE5	GO:0033293	monocarboxylic acid binding	Losses
LE5	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
LE5	GO:0020037	heme binding	Losses
LE5	GO:0046906	tetrapyrrole binding	Losses
LE5	GO:0008238	exopeptidase activity	Losses
LE5	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
LE5	GO:0008194	UDP-glycosyltransferase activity	Losses
LE5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
LE5	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
LE5	GO:0003896	DNA primase activity	Losses
LE5	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Losses
LE5	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
LE5	GO:0004161	dimethylallyltranstransferase activity	Losses
LE5	GO:0004827	proline-tRNA ligase activity	Losses
LE5	GO:0004818	glutamate-tRNA ligase activity	Losses
LE5	GO:0004819	glutamine-tRNA ligase activity	Losses
LE5	GO:0030276	clathrin binding	Losses
LE5	GO:0004617	phosphoglycerate dehydrogenase activity	Losses
LE5	GO:1901677	phosphate transmembrane transporter activity	Losses
LE5	GO:0004064	arylesterase activity	Losses
LE5	GO:0015114	phosphate ion transmembrane transporter activity	Losses
LE5	GO:0015294	solute:cation symporter activity	Losses
LE5	GO:0016782	transferase activity, transferring sulfur-containing groups	Losses
LE5	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
LE5	GO:0015171	amino acid transmembrane transporter activity	Losses
LE5	GO:0004601	peroxidase activity	Losses
LE5	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
LE5	GO:0016758	transferase activity, transferring hexosyl groups	Losses
LE5	GO:0050660	flavin adenine dinucleotide binding	Losses
LE5	GO:0015081	sodium ion transmembrane transporter activity	Extinctions
LE5	GO:0008812	choline dehydrogenase activity	Extinctions
LE5	GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
LE5	GO:0005272	sodium channel activity	Extinctions
LE5	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Extinctions
LE5	GO:0003896	DNA primase activity	Extinctions
LE5	GO:0047915	ganglioside galactosyltransferase activity	Extinctions
LE5	GO:0015385	sodium:proton antiporter activity	Extinctions
LE5	GO:0042302	structural constituent of cuticle	Extinctions
LE5	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
LE5	GO:0005451	monovalent cation:proton antiporter activity	Extinctions
LE5	GO:0034062	5'-3' RNA polymerase activity	Extinctions
LE5	GO:0097747	RNA polymerase activity	Extinctions
LE5	GO:0004344	glucose dehydrogenase activity	Extinctions
LE5	GO:0050660	flavin adenine dinucleotide binding	Extinctions
LE5	GO:0046873	metal ion transmembrane transporter activity	Extinctions
LE5	GO:0004185	serine-type carboxypeptidase activity	Extinctions
LE5	GO:0003677	DNA binding	Extinctions
LE5	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
LE5	GO:0070008	serine-type exopeptidase activity	Extinctions
LE5	GO:0015491	cation:cation antiporter activity	Extinctions
LE5	GO:0008484	sulfuric ester hydrolase activity	Extinctions
LE5	GO:0015299	solute:proton antiporter activity	Extinctions
LE5	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
LE5	GO:0035250	UDP-galactosyltransferase activity	Extinctions
LE5	GO:0099516	ion antiporter activity	Extinctions
HHALY	GO:0140097	catalytic activity, acting on DNA	Gains
HHALY	GO:0003964	RNA-directed DNA polymerase activity	Gains
HHALY	GO:0003824	catalytic activity	Gains
HHALY	GO:0034061	DNA polymerase activity	Gains
HHALY	GO:0016787	hydrolase activity	Gains
HHALY	GO:0004497	monooxygenase activity	Gains
HHALY	GO:0016779	nucleotidyltransferase activity	Gains
HHALY	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
HHALY	GO:0046914	transition metal ion binding	Gains
HHALY	GO:0004185	serine-type carboxypeptidase activity	Gains
HHALY	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Gains
HHALY	GO:0022804	active transmembrane transporter activity	Gains
HHALY	GO:0043492	ATPase activity, coupled to movement of substances	Gains
HHALY	GO:0015399	primary active transmembrane transporter activity	Gains
HHALY	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Gains
HHALY	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Gains
HHALY	GO:0003916	DNA topoisomerase activity	Gains
HHALY	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Gains
HHALY	GO:0045289	luciferin monooxygenase activity	Gains
HHALY	GO:0070008	serine-type exopeptidase activity	Gains
HHALY	GO:0015408	ferric-transporting ATPase activity	Gains
HHALY	GO:0015091	ferric iron transmembrane transporter activity	Gains
HHALY	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
HHALY	GO:0005496	steroid binding	Gains
HHALY	GO:0004180	carboxypeptidase activity	Gains
HHALY	GO:0008094	DNA-dependent ATPase activity	Gains
HHALY	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
HHALY	GO:0004344	glucose dehydrogenase activity	Gains
HHALY	GO:0061505	DNA topoisomerase II activity	Gains
HHALY	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	Gains
HHALY	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
HHALY	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HHALY	GO:0008270	zinc ion binding	Gains
HHALY	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Gains
HHALY	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HHALY	GO:0019187	beta-1,4-mannosyltransferase activity	Gains
HHALY	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
HHALY	GO:0004040	amidase activity	Gains
HHALY	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Gains
HHALY	GO:0004335	galactokinase activity	Gains
HHALY	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
HHALY	GO:0050591	quinine 3-monooxygenase activity	Gains
HHALY	GO:0018685	alkane 1-monooxygenase activity	Gains
HHALY	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
HHALY	GO:0005215	transporter activity	Gains
HHALY	GO:0016491	oxidoreductase activity	Gains
HHALY	GO:0022857	transmembrane transporter activity	Gains
HHALY	GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
HHALY	GO:0005506	iron ion binding	Gains
HHALY	GO:0016853	isomerase activity	Gains
HHALY	GO:0005381	iron ion transmembrane transporter activity	Gains
HHALY	GO:0008812	choline dehydrogenase activity	Gains
HHALY	GO:0070330	aromatase activity	Gains
HHALY	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HHALY	GO:0090484	drug transporter activity	Gains
HHALY	GO:0015238	drug transmembrane transporter activity	Gains
HHALY	GO:0042623	ATPase activity, coupled	Gains
HHALY	GO:0046906	tetrapyrrole binding	Gains
HHALY	GO:0020037	heme binding	Gains
HHALY	GO:0016740	transferase activity	Gains
HHALY	GO:0016887	ATPase activity	Gains
HHALY	GO:0004725	protein tyrosine phosphatase activity	Gains
HHALY	GO:0003777	microtubule motor activity	Gains
HHALY	GO:0016801	hydrolase activity, acting on ether bonds	Gains
HHALY	GO:0015925	galactosidase activity	Gains
HHALY	GO:0004013	adenosylhomocysteinase activity	Gains
HHALY	GO:0004035	alkaline phosphatase activity	Gains
HHALY	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
HHALY	GO:0015114	phosphate ion transmembrane transporter activity	Gains
HHALY	GO:0015101	organic cation transmembrane transporter activity	Gains
HHALY	GO:1901677	phosphate transmembrane transporter activity	Gains
HHALY	GO:0003917	DNA topoisomerase type I activity	Gains
HHALY	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
HHALY	GO:0004500	dopamine beta-monooxygenase activity	Gains
HHALY	GO:0004654	polyribonucleotide nucleotidyltransferase activity	Gains
HHALY	GO:0016802	trialkylsulfonium hydrolase activity	Gains
HHALY	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HHALY	GO:0016791	phosphatase activity	Gains
HHALY	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
HHALY	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
HHALY	GO:0005272	sodium channel activity	Gains
HHALY	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Gains
HHALY	GO:0004300	enoyl-CoA hydratase activity	Gains
HHALY	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
HHALY	GO:0016411	acylglycerol O-acyltransferase activity	Gains
HHALY	GO:0016408	C-acyltransferase activity	Gains
HHALY	GO:0016886	ligase activity, forming phosphoric ester bonds	Gains
HHALY	GO:0004629	phospholipase C activity	Gains
HHALY	GO:0008289	lipid binding	Gains
HHALY	GO:0019829	cation-transporting ATPase activity	Gains
HHALY	GO:0042054	histone methyltransferase activity	Gains
HHALY	GO:0008276	protein methyltransferase activity	Gains
HHALY	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
HHALY	GO:0042910	xenobiotic transmembrane transporter activity	Gains
HHALY	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
HHALY	GO:0004930	G-protein coupled receptor activity	Losses
HHALY	GO:0003964	RNA-directed DNA polymerase activity	Losses
HHALY	GO:0004888	transmembrane signaling receptor activity	Losses
HHALY	GO:0099600	transmembrane receptor activity	Losses
HHALY	GO:0038023	signaling receptor activity	Losses
HHALY	GO:0004872	receptor activity	Losses
HHALY	GO:0060089	molecular transducer activity	Losses
HHALY	GO:0008528	G-protein coupled peptide receptor activity	Losses
HHALY	GO:0001653	peptide receptor activity	Losses
HHALY	GO:0004871	signal transducer activity	Losses
HHALY	GO:0034061	DNA polymerase activity	Losses
HHALY	GO:0008188	neuropeptide receptor activity	Losses
HHALY	GO:0043565	sequence-specific DNA binding	Losses
HHALY	GO:0140097	catalytic activity, acting on DNA	Losses
HHALY	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HHALY	GO:0003700	DNA binding transcription factor activity	Losses
HHALY	GO:0008061	chitin binding	Losses
HHALY	GO:0003676	nucleic acid binding	Losses
HHALY	GO:0005549	odorant binding	Losses
HHALY	GO:0019239	deaminase activity	Losses
HHALY	GO:0004950	chemokine receptor activity	Losses
HHALY	GO:0004977	melanocortin receptor activity	Losses
HHALY	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
HHALY	GO:0004000	adenosine deaminase activity	Losses
HHALY	GO:0044212	transcription regulatory region DNA binding	Losses
HHALY	GO:0004993	G-protein coupled serotonin receptor activity	Losses
HHALY	GO:0099589	serotonin receptor activity	Losses
HHALY	GO:0001067	regulatory region nucleic acid binding	Losses
HHALY	GO:0000975	regulatory region DNA binding	Losses
HHALY	GO:0008227	G-protein coupled amine receptor activity	Losses
HHALY	GO:0016779	nucleotidyltransferase activity	Losses
HHALY	GO:0004935	adrenergic receptor activity	Losses
HHALY	GO:0030296	protein tyrosine kinase activator activity	Losses
HHALY	GO:0019992	diacylglycerol binding	Losses
HHALY	GO:0004896	cytokine receptor activity	Losses
HHALY	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
HHALY	GO:0004983	neuropeptide Y receptor activity	Losses
HHALY	GO:0001158	enhancer sequence-specific DNA binding	Losses
HHALY	GO:0035326	enhancer binding	Losses
HHALY	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
HHALY	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
HHALY	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
HHALY	GO:0030546	receptor activator activity	Losses
HHALY	GO:0030545	receptor regulator activity	Losses
HHALY	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
HHALY	GO:0140110	transcription regulator activity	Losses
HHALY	GO:0015368	calcium:cation antiporter activity	Losses
HHALY	GO:0031208	POZ domain binding	Losses
HHALY	GO:0030246	carbohydrate binding	Losses
HHALY	GO:0016722	oxidoreductase activity, oxidizing metal ions	Losses
HHALY	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
HHALY	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
HHALY	GO:0005506	iron ion binding	Losses
HHALY	GO:0019887	protein kinase regulator activity	Losses
HHALY	GO:0030594	neurotransmitter receptor activity	Losses
HHALY	GO:0016500	protein-hormone receptor activity	Losses
HHALY	GO:0019209	kinase activator activity	Losses
HHALY	GO:0015269	calcium-activated potassium channel activity	Losses
HHALY	GO:0030295	protein kinase activator activity	Losses
HHALY	GO:0015267	channel activity	Losses
HHALY	GO:0022803	passive transmembrane transporter activity	Losses
HHALY	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HHALY	GO:0003677	DNA binding	Losses
HHALY	GO:1990837	sequence-specific double-stranded DNA binding	Losses
HHALY	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HHALY	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
HHALY	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
HHALY	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
HHALY	GO:0004129	cytochrome-c oxidase activity	Losses
HHALY	GO:0015002	heme-copper terminal oxidase activity	Losses
HHALY	GO:0005230	extracellular ligand-gated ion channel activity	Losses
HHALY	GO:0022838	substrate-specific channel activity	Losses
HHALY	GO:0004930	G-protein coupled receptor activity	Extinctions
HHALY	GO:0004888	transmembrane signaling receptor activity	Extinctions
HHALY	GO:0099600	transmembrane receptor activity	Extinctions
HHALY	GO:0038023	signaling receptor activity	Extinctions
HHALY	GO:0004872	receptor activity	Extinctions
HHALY	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HHALY	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
HHALY	GO:0001653	peptide receptor activity	Extinctions
HHALY	GO:0060089	molecular transducer activity	Extinctions
HHALY	GO:0004871	signal transducer activity	Extinctions
HHALY	GO:0008188	neuropeptide receptor activity	Extinctions
HHALY	GO:0034061	DNA polymerase activity	Extinctions
HHALY	GO:0008061	chitin binding	Extinctions
HHALY	GO:0005549	odorant binding	Extinctions
HHALY	GO:0016722	oxidoreductase activity, oxidizing metal ions	Extinctions
HHALY	GO:0003676	nucleic acid binding	Extinctions
HHALY	GO:0019239	deaminase activity	Extinctions
HHALY	GO:0004000	adenosine deaminase activity	Extinctions
HHALY	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
HHALY	GO:0030546	receptor activator activity	Extinctions
HHALY	GO:0015269	calcium-activated potassium channel activity	Extinctions
HHALY	GO:0030594	neurotransmitter receptor activity	Extinctions
HHALY	GO:0008227	G-protein coupled amine receptor activity	Extinctions
HHALY	GO:0005506	iron ion binding	Extinctions
HHALY	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
HHALY	GO:0004983	neuropeptide Y receptor activity	Extinctions
HHALY	GO:0140104	molecular carrier activity	Extinctions
HHALY	GO:0004935	adrenergic receptor activity	Extinctions
HHALY	GO:0005227	calcium activated cation channel activity	Extinctions
HHALY	GO:0071855	neuropeptide receptor binding	Extinctions
HHALY	GO:0005267	potassium channel activity	Extinctions
HHALY	GO:0042805	actinin binding	Extinctions
HHALY	GO:0004950	chemokine receptor activity	Extinctions
HHALY	GO:0030306	ADP-ribosylation factor binding	Extinctions
HHALY	GO:0051393	alpha-actinin binding	Extinctions
HHALY	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
HHALY	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	Extinctions
HHALY	GO:0016855	racemase and epimerase activity, acting on amino acids and derivatives	Extinctions
HHALY	GO:0001637	G-protein coupled chemoattractant receptor activity	Extinctions
HHALY	GO:0140097	catalytic activity, acting on DNA	Extinctions
HHALY	GO:0005184	neuropeptide hormone activity	Extinctions
HHALY	GO:0030545	receptor regulator activity	Extinctions
HHALY	GO:0022839	ion gated channel activity	Extinctions
HHALY	GO:0017137	Rab GTPase binding	Extinctions
HHALY	GO:0016779	nucleotidyltransferase activity	Extinctions
HHALY	GO:0005216	ion channel activity	Extinctions
HHALY	GO:0005344	oxygen carrier activity	Extinctions
HHALY	GO:0030296	protein tyrosine kinase activator activity	Extinctions
HHALY	GO:0019992	diacylglycerol binding	Extinctions
HHALY	GO:0004896	cytokine receptor activity	Extinctions
HHALY	GO:0022838	substrate-specific channel activity	Extinctions
HY19	GO:0004984	olfactory receptor activity	Gains
HY19	GO:0019992	diacylglycerol binding	Gains
HY19	GO:0005549	odorant binding	Gains
HY19	GO:0004930	G-protein coupled receptor activity	Gains
HY19	GO:0015370	solute:sodium symporter activity	Gains
HY19	GO:0003774	motor activity	Gains
HY19	GO:0004888	transmembrane signaling receptor activity	Gains
HY19	GO:0015291	secondary active transmembrane transporter activity	Gains
HY19	GO:0015081	sodium ion transmembrane transporter activity	Gains
HY19	GO:0005025	transforming growth factor beta receptor activity, type I	Gains
HY19	GO:0016361	activin receptor activity, type I	Gains
HY19	GO:0050431	transforming growth factor beta binding	Gains
HY19	GO:0005436	sodium:phosphate symporter activity	Gains
HY19	GO:0099600	transmembrane receptor activity	Gains
HY19	GO:0015294	solute:cation symporter activity	Gains
HY19	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
HY19	GO:0000146	microfilament motor activity	Gains
HY19	GO:0048185	activin binding	Gains
HY19	GO:0017018	myosin phosphatase activity	Gains
HY19	GO:0017002	activin-activated receptor activity	Gains
HY19	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
HY19	GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
HY19	GO:0004371	glycerone kinase activity	Gains
HY19	GO:0004348	glucosylceramidase activity	Gains
HY19	GO:0004337	geranyltranstransferase activity	Gains
HY19	GO:0070594	juvenile hormone response element binding	Gains
HY19	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Gains
HY19	GO:0038023	signaling receptor activity	Gains
HY19	GO:0032440	2-alkenal reductase [NAD(P)] activity	Gains
HY19	GO:0015293	symporter activity	Gains
HY19	GO:0019838	growth factor binding	Gains
HY19	GO:0003910	DNA ligase (ATP) activity	Gains
HY19	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
HY19	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
HY19	GO:0004161	dimethylallyltranstransferase activity	Gains
HY19	GO:0030898	actin-dependent ATPase activity	Gains
HY19	GO:0004774	succinate-CoA ligase activity	Gains
HY19	GO:0004775	succinate-CoA ligase (ADP-forming) activity	Gains
HY19	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Gains
HY19	GO:0004703	G-protein coupled receptor kinase activity	Gains
HY19	GO:0015114	phosphate ion transmembrane transporter activity	Gains
HY19	GO:0003909	DNA ligase activity	Gains
HY19	GO:0070006	metalloaminopeptidase activity	Gains
HY19	GO:1901677	phosphate transmembrane transporter activity	Gains
HY19	GO:0015385	sodium:proton antiporter activity	Gains
HY19	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY19	GO:0034061	DNA polymerase activity	Losses
HY19	GO:0070001	aspartic-type peptidase activity	Losses
HY19	GO:0004190	aspartic-type endopeptidase activity	Losses
HY19	GO:0016779	nucleotidyltransferase activity	Losses
HY19	GO:0140097	catalytic activity, acting on DNA	Losses
HY19	GO:0008270	zinc ion binding	Losses
HY19	GO:0046914	transition metal ion binding	Losses
HY19	GO:0004175	endopeptidase activity	Losses
HY19	GO:0008233	peptidase activity	Losses
HY19	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY19	GO:0046872	metal ion binding	Losses
HY19	GO:0043169	cation binding	Losses
HY19	GO:0004519	endonuclease activity	Losses
HY19	GO:0004518	nuclease activity	Losses
HY19	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY19	GO:0003676	nucleic acid binding	Losses
HY19	GO:0008237	metallopeptidase activity	Losses
HY19	GO:0005201	extracellular matrix structural constituent	Losses
HY19	GO:0004222	metalloendopeptidase activity	Losses
HY19	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY19	GO:0042302	structural constituent of cuticle	Losses
HY19	GO:0004521	endoribonuclease activity	Losses
HY19	GO:0003677	DNA binding	Losses
HY19	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
HY19	GO:0004984	olfactory receptor activity	Losses
HY19	GO:0004803	transposase activity	Losses
HY19	GO:0004866	endopeptidase inhibitor activity	Losses
HY19	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY19	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HY19	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Losses
HY19	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
HY19	GO:0061135	endopeptidase regulator activity	Losses
HY19	GO:0008188	neuropeptide receptor activity	Losses
HY19	GO:0003723	RNA binding	Losses
HY19	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY19	GO:0004540	ribonuclease activity	Losses
HY19	GO:0004930	G-protein coupled receptor activity	Losses
HY19	GO:0140096	catalytic activity, acting on a protein	Losses
HY19	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
HY19	GO:0008528	G-protein coupled peptide receptor activity	Losses
HY19	GO:0097493	structural molecule activity conferring elasticity	Losses
HY19	GO:0035198	miRNA binding	Losses
HY19	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
HY19	GO:0004038	allantoinase activity	Losses
HY19	GO:0042925	benzoate transmembrane transporter activity	Losses
HY19	GO:0050897	cobalt ion binding	Losses
HY19	GO:0070735	protein-glycine ligase activity	Losses
HY19	GO:0070736	protein-glycine ligase activity, initiating	Losses
HY19	GO:0070737	protein-glycine ligase activity, elongating	Losses
HY19	GO:0004145	diamine N-acetyltransferase activity	Losses
HY19	GO:0001653	peptide receptor activity	Losses
HY19	GO:0005549	odorant binding	Losses
HY19	GO:0030414	peptidase inhibitor activity	Losses
HY19	GO:0016787	hydrolase activity	Losses
HY19	GO:0016874	ligase activity	Losses
HY19	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
HY19	GO:0004983	neuropeptide Y receptor activity	Losses
HY19	GO:0005214	structural constituent of chitin-based cuticle	Losses
HY19	GO:0061134	peptidase regulator activity	Losses
HY19	GO:0004871	signal transducer activity	Losses
HY19	GO:0004555	alpha,alpha-trehalase activity	Losses
HY19	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
HY19	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
HY19	GO:0004950	chemokine receptor activity	Losses
HY19	GO:0005212	structural constituent of eye lens	Losses
HY19	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
HY19	GO:0015927	trehalase activity	Losses
HY19	GO:0140098	catalytic activity, acting on RNA	Losses
HY19	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
HY19	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HY19	GO:0099600	transmembrane receptor activity	Losses
HY19	GO:0034062	5'-3' RNA polymerase activity	Losses
HY19	GO:0004857	enzyme inhibitor activity	Losses
HY19	GO:0097747	RNA polymerase activity	Losses
HY19	GO:0016881	acid-amino acid ligase activity	Losses
HY19	GO:0004736	pyruvate carboxylase activity	Losses
HY19	GO:0004896	cytokine receptor activity	Losses
HY19	GO:0035197	siRNA binding	Losses
HY19	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
HY19	GO:0004784	superoxide dismutase activity	Losses
HY19	GO:0004771	sterol esterase activity	Losses
HY19	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY19	GO:0070001	aspartic-type peptidase activity	Extinctions
HY19	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY19	GO:0034061	DNA polymerase activity	Extinctions
HY19	GO:0004175	endopeptidase activity	Extinctions
HY19	GO:0008233	peptidase activity	Extinctions
HY19	GO:0008270	zinc ion binding	Extinctions
HY19	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY19	GO:0046914	transition metal ion binding	Extinctions
HY19	GO:0016779	nucleotidyltransferase activity	Extinctions
HY19	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
HY19	GO:0008188	neuropeptide receptor activity	Extinctions
HY19	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
HY19	GO:0001653	peptide receptor activity	Extinctions
HY19	GO:0003676	nucleic acid binding	Extinctions
HY19	GO:0046872	metal ion binding	Extinctions
HY19	GO:0043169	cation binding	Extinctions
HY19	GO:0004983	neuropeptide Y receptor activity	Extinctions
HY19	GO:0004038	allantoinase activity	Extinctions
HY19	GO:0042925	benzoate transmembrane transporter activity	Extinctions
HY19	GO:0050897	cobalt ion binding	Extinctions
HY19	GO:0004145	diamine N-acetyltransferase activity	Extinctions
HY19	GO:0004222	metalloendopeptidase activity	Extinctions
HY19	GO:0001637	G-protein coupled chemoattractant receptor activity	Extinctions
HY19	GO:0004950	chemokine receptor activity	Extinctions
HY19	GO:0004866	endopeptidase inhibitor activity	Extinctions
HY19	GO:0004930	G-protein coupled receptor activity	Extinctions
HY19	GO:0061135	endopeptidase regulator activity	Extinctions
HY19	GO:0004623	phospholipase A2 activity	Extinctions
HY19	GO:0004736	pyruvate carboxylase activity	Extinctions
HY19	GO:0004896	cytokine receptor activity	Extinctions
HY19	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Extinctions
HY19	GO:0004871	signal transducer activity	Extinctions
HY19	GO:0030414	peptidase inhibitor activity	Extinctions
HY19	GO:0004075	biotin carboxylase activity	Extinctions
HY19	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
EDANI	GO:0000156	phosphorelay response regulator activity	Gains
EDANI	GO:0048037	cofactor binding	Gains
EDANI	GO:0030170	pyridoxal phosphate binding	Gains
EDANI	GO:0070279	vitamin B6 binding	Gains
EDANI	GO:0019842	vitamin binding	Gains
EDANI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
EDANI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
EDANI	GO:0051539	4 iron, 4 sulfur cluster binding	Gains
EDANI	GO:0016829	lyase activity	Gains
EDANI	GO:0046906	tetrapyrrole binding	Gains
EDANI	GO:0016491	oxidoreductase activity	Gains
EDANI	GO:0016783	sulfurtransferase activity	Gains
EDANI	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
EDANI	GO:0020037	heme binding	Gains
EDANI	GO:0050662	coenzyme binding	Gains
EDANI	GO:0097159	organic cyclic compound binding	Gains
EDANI	GO:1901363	heterocyclic compound binding	Gains
EDANI	GO:0003824	catalytic activity	Gains
EDANI	GO:0004871	signal transducer activity	Gains
EDANI	GO:0005549	odorant binding	Gains
EDANI	GO:0005201	extracellular matrix structural constituent	Gains
EDANI	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
EDANI	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Gains
EDANI	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
EDANI	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
EDANI	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
EDANI	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	Gains
EDANI	GO:0031419	cobalamin binding	Gains
EDANI	GO:0005550	pheromone binding	Gains
EDANI	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
EDANI	GO:0004497	monooxygenase activity	Gains
EDANI	GO:0004930	G-protein coupled receptor activity	Gains
EDANI	GO:0030246	carbohydrate binding	Gains
EDANI	GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
EDANI	GO:0036094	small molecule binding	Gains
EDANI	GO:0043168	anion binding	Gains
EDANI	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
EDANI	GO:0008061	chitin binding	Gains
EDANI	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
EDANI	GO:0004673	protein histidine kinase activity	Gains
EDANI	GO:0004312	fatty acid synthase activity	Gains
EDANI	GO:0019202	amino acid kinase activity	Gains
EDANI	GO:0008172	S-methyltransferase activity	Gains
EDANI	GO:0005506	iron ion binding	Gains
EDANI	GO:0008483	transaminase activity	Gains
EDANI	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
EDANI	GO:0004812	aminoacyl-tRNA ligase activity	Gains
EDANI	GO:0008171	O-methyltransferase activity	Gains
EDANI	GO:0016835	carbon-oxygen lyase activity	Gains
EDANI	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
EDANI	GO:0016854	racemase and epimerase activity	Gains
EDANI	GO:0016453	C-acetyltransferase activity	Gains
EDANI	GO:0016842	amidine-lyase activity	Gains
EDANI	GO:0016838	carbon-oxygen lyase activity, acting on phosphates	Gains
EDANI	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Gains
EDANI	GO:0016500	protein-hormone receptor activity	Gains
EDANI	GO:0008658	penicillin binding	Gains
EDANI	GO:0051287	NAD binding	Gains
EDANI	GO:0140101	catalytic activity, acting on a tRNA	Gains
EDANI	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
EDANI	GO:0097367	carbohydrate derivative binding	Gains
EDANI	GO:0003964	RNA-directed DNA polymerase activity	Losses
EDANI	GO:0046914	transition metal ion binding	Losses
EDANI	GO:0034061	DNA polymerase activity	Losses
EDANI	GO:0008812	choline dehydrogenase activity	Losses
EDANI	GO:0004344	glucose dehydrogenase activity	Losses
EDANI	GO:0008270	zinc ion binding	Losses
EDANI	GO:0016531	copper chaperone activity	Losses
EDANI	GO:0140097	catalytic activity, acting on DNA	Losses
EDANI	GO:0035250	UDP-galactosyltransferase activity	Losses
EDANI	GO:0004526	ribonuclease P activity	Losses
EDANI	GO:0008234	cysteine-type peptidase activity	Losses
EDANI	GO:0004540	ribonuclease activity	Losses
EDANI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
EDANI	GO:0046592	polyamine oxidase activity	Losses
EDANI	GO:0016530	metallochaperone activity	Losses
EDANI	GO:0022857	transmembrane transporter activity	Losses
EDANI	GO:0046872	metal ion binding	Losses
EDANI	GO:0005215	transporter activity	Losses
EDANI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
EDANI	GO:0016779	nucleotidyltransferase activity	Losses
EDANI	GO:0008378	galactosyltransferase activity	Losses
EDANI	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
EDANI	GO:0043169	cation binding	Losses
EDANI	GO:0004519	endonuclease activity	Losses
EDANI	GO:0004190	aspartic-type endopeptidase activity	Losses
EDANI	GO:0070001	aspartic-type peptidase activity	Losses
EDANI	GO:0008188	neuropeptide receptor activity	Losses
EDANI	GO:0004518	nuclease activity	Losses
EDANI	GO:0004521	endoribonuclease activity	Losses
EDANI	GO:0004549	tRNA-specific ribonuclease activity	Losses
EDANI	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Losses
EDANI	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
EDANI	GO:0016015	morphogen activity	Losses
EDANI	GO:0008061	chitin binding	Losses
EDANI	GO:0008528	G-protein coupled peptide receptor activity	Losses
EDANI	GO:0022892	substrate-specific transporter activity	Losses
EDANI	GO:0005507	copper ion binding	Losses
EDANI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
EDANI	GO:0001653	peptide receptor activity	Losses
EDANI	GO:0016790	thiolester hydrolase activity	Losses
EDANI	GO:0140103	catalytic activity, acting on a glycoprotein	Losses
EDANI	GO:0022891	substrate-specific transmembrane transporter activity	Losses
EDANI	GO:0004784	superoxide dismutase activity	Losses
EDANI	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
EDANI	GO:0140104	molecular carrier activity	Losses
EDANI	GO:0045296	cadherin binding	Losses
EDANI	GO:0016531	copper chaperone activity	Extinctions
EDANI	GO:0004526	ribonuclease P activity	Extinctions
EDANI	GO:0016530	metallochaperone activity	Extinctions
EDANI	GO:0034061	DNA polymerase activity	Extinctions
EDANI	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
EDANI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
EDANI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
EDANI	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Extinctions
EDANI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
EDANI	GO:0046914	transition metal ion binding	Extinctions
EDANI	GO:0008061	chitin binding	Extinctions
EDANI	GO:0140104	molecular carrier activity	Extinctions
EDANI	GO:0016779	nucleotidyltransferase activity	Extinctions
EDANI	GO:0008270	zinc ion binding	Extinctions
EDANI	GO:0140097	catalytic activity, acting on DNA	Extinctions
EDANI	GO:0004540	ribonuclease activity	Extinctions
EDANI	GO:0008568	microtubule-severing ATPase activity	Extinctions
EDANI	GO:0016499	orexin receptor activity	Extinctions
EDANI	GO:0019784	NEDD8-specific protease activity	Extinctions
EDANI	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	Extinctions
EDANI	GO:0034452	dynactin binding	Extinctions
EDANI	GO:0005125	cytokine activity	Extinctions
EDANI	GO:0010385	double-stranded methylated DNA binding	Extinctions
EDANI	GO:0016532	superoxide dismutase copper chaperone activity	Extinctions
EDANI	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Extinctions
EDANI	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Extinctions
EDANI	GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
EDANI	GO:0008084	imaginal disc growth factor receptor binding	Extinctions
EDANI	GO:0030586	[methionine synthase] reductase activity	Extinctions
EDANI	GO:0004371	glycerone kinase activity	Extinctions
EDANI	GO:0016722	oxidoreductase activity, oxidizing metal ions	Extinctions
EDANI	GO:1990939	ATP-dependent microtubule motor activity	Extinctions
AMELL	GO:0004984	olfactory receptor activity	Gains
AMELL	GO:0005549	odorant binding	Gains
AMELL	GO:0004930	G-protein coupled receptor activity	Gains
AMELL	GO:0038023	signaling receptor activity	Gains
AMELL	GO:0004871	signal transducer activity	Gains
AMELL	GO:0004888	transmembrane signaling receptor activity	Gains
AMELL	GO:0099600	transmembrane receptor activity	Gains
AMELL	GO:0004872	receptor activity	Gains
AMELL	GO:0060089	molecular transducer activity	Gains
AMELL	GO:0051219	phosphoprotein binding	Gains
AMELL	GO:0043169	cation binding	Gains
AMELL	GO:0003964	RNA-directed DNA polymerase activity	Gains
AMELL	GO:0046872	metal ion binding	Gains
AMELL	GO:0008527	taste receptor activity	Gains
AMELL	GO:0042302	structural constituent of cuticle	Gains
AMELL	GO:0034061	DNA polymerase activity	Gains
AMELL	GO:0005342	organic acid transmembrane transporter activity	Gains
AMELL	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
AMELL	GO:0030971	receptor tyrosine kinase binding	Gains
AMELL	GO:1990782	protein tyrosine kinase binding	Gains
AMELL	GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
AMELL	GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
AMELL	GO:0052834	inositol monophosphate phosphatase activity	Gains
AMELL	GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
AMELL	GO:0008519	ammonium transmembrane transporter activity	Gains
AMELL	GO:0015293	symporter activity	Gains
AMELL	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
AMELL	GO:0046914	transition metal ion binding	Gains
AMELL	GO:0015294	solute:cation symporter activity	Gains
AMELL	GO:0008514	organic anion transmembrane transporter activity	Gains
AMELL	GO:0008483	transaminase activity	Gains
AMELL	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
AMELL	GO:0005343	organic acid:sodium symporter activity	Gains
AMELL	GO:0008417	fucosyltransferase activity	Gains
AMELL	GO:0003747	translation release factor activity	Gains
AMELL	GO:0008079	translation termination factor activity	Gains
AMELL	GO:0019992	diacylglycerol binding	Gains
AMELL	GO:0004977	melanocortin receptor activity	Gains
AMELL	GO:0015037	peptide disulfide oxidoreductase activity	Gains
AMELL	GO:0015038	glutathione disulfide oxidoreductase activity	Gains
AMELL	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
AMELL	GO:1901618	organic hydroxy compound transmembrane transporter activity	Gains
AMELL	GO:0008270	zinc ion binding	Gains
AMELL	GO:0005506	iron ion binding	Gains
AMELL	GO:0019842	vitamin binding	Gains
AMELL	GO:0005214	structural constituent of chitin-based cuticle	Gains
AMELL	GO:0015370	solute:sodium symporter activity	Gains
AMELL	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
AMELL	GO:0015296	anion:cation symporter activity	Gains
AMELL	GO:0004629	phospholipase C activity	Gains
AMELL	GO:0019901	protein kinase binding	Gains
AMELL	GO:0016803	ether hydrolase activity	Gains
AMELL	GO:0008889	glycerophosphodiester phosphodiesterase activity	Gains
AMELL	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
AMELL	GO:0042043	neurexin family protein binding	Gains
AMELL	GO:0032403	protein complex binding	Gains
AMELL	GO:0019900	kinase binding	Gains
AMELL	GO:0003963	RNA-3'-phosphate cyclase activity	Losses
AMELL	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Losses
AMELL	GO:0016859	cis-trans isomerase activity	Losses
AMELL	GO:0016886	ligase activity, forming phosphoric ester bonds	Losses
AMELL	GO:0004104	cholinesterase activity	Losses
AMELL	GO:0003990	acetylcholinesterase activity	Losses
AMELL	GO:0004190	aspartic-type endopeptidase activity	Losses
AMELL	GO:0070001	aspartic-type peptidase activity	Losses
AMELL	GO:0042284	sphingolipid delta-4 desaturase activity	Losses
AMELL	GO:0004355	glutamate synthase (NADPH) activity	Losses
AMELL	GO:0015930	glutamate synthase activity	Losses
AMELL	GO:0032542	sulfiredoxin activity	Losses
AMELL	GO:0045181	glutamate synthase activity, NAD(P)H as acceptor	Losses
AMELL	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
AMELL	GO:0016040	glutamate synthase (NADH) activity	Losses
AMELL	GO:0004552	octanol dehydrogenase activity	Losses
AMELL	GO:0004667	prostaglandin-D synthase activity	Losses
AMELL	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
AMELL	GO:0080007	S-nitrosoglutathione reductase activity	Losses
AMELL	GO:0004605	phosphatidate cytidylyltransferase activity	Losses
AMELL	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Losses
AMELL	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity	Losses
AMELL	GO:0010181	FMN binding	Losses
AMELL	GO:0016779	nucleotidyltransferase activity	Losses
AMELL	GO:0052689	carboxylic ester hydrolase activity	Losses
AMELL	GO:0016853	isomerase activity	Losses
AMELL	GO:0004363	glutathione synthase activity	Losses
AMELL	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Losses
AMELL	GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	Losses
AMELL	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Losses
AMELL	GO:0019187	beta-1,4-mannosyltransferase activity	Losses
AMELL	GO:0046923	ER retention sequence binding	Losses
AMELL	GO:0098518	polynucleotide phosphatase activity	Losses
AMELL	GO:0048244	phytanoyl-CoA dioxygenase activity	Losses
AMELL	GO:0015301	anion:anion antiporter activity	Losses
AMELL	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
AMELL	GO:0050591	quinine 3-monooxygenase activity	Losses
AMELL	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Losses
AMELL	GO:0008967	phosphoglycolate phosphatase activity	Losses
AMELL	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
AMELL	GO:0016788	hydrolase activity, acting on ester bonds	Losses
AMELL	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
AMELL	GO:0016859	cis-trans isomerase activity	Extinctions
AMELL	GO:0042284	sphingolipid delta-4 desaturase activity	Extinctions
AMELL	GO:0032542	sulfiredoxin activity	Extinctions
AMELL	GO:0004605	phosphatidate cytidylyltransferase activity	Extinctions
AMELL	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Extinctions
AMELL	GO:0019187	beta-1,4-mannosyltransferase activity	Extinctions
AMELL	GO:0046923	ER retention sequence binding	Extinctions
AMELL	GO:0048244	phytanoyl-CoA dioxygenase activity	Extinctions
AMELL	GO:0015301	anion:anion antiporter activity	Extinctions
AMELL	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Extinctions
AMELL	GO:0008967	phosphoglycolate phosphatase activity	Extinctions
AMELL	GO:0016853	isomerase activity	Extinctions
AMELL	GO:0052689	carboxylic ester hydrolase activity	Extinctions
AMELL	GO:0004064	arylesterase activity	Extinctions
AMELL	GO:0005452	inorganic anion exchanger activity	Extinctions
AMELL	GO:0004864	protein phosphatase inhibitor activity	Extinctions
AMELL	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Extinctions
AMELL	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Extinctions
AMELL	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Extinctions
AMELL	GO:0016779	nucleotidyltransferase activity	Extinctions
SMARI	GO:0003964	RNA-directed DNA polymerase activity	Gains
SMARI	GO:0005272	sodium channel activity	Gains
SMARI	GO:0022838	substrate-specific channel activity	Gains
SMARI	GO:0005216	ion channel activity	Gains
SMARI	GO:0015267	channel activity	Gains
SMARI	GO:0022803	passive transmembrane transporter activity	Gains
SMARI	GO:0070001	aspartic-type peptidase activity	Gains
SMARI	GO:0004190	aspartic-type endopeptidase activity	Gains
SMARI	GO:0015081	sodium ion transmembrane transporter activity	Gains
SMARI	GO:0034061	DNA polymerase activity	Gains
SMARI	GO:0140097	catalytic activity, acting on DNA	Gains
SMARI	GO:0099600	transmembrane receptor activity	Gains
SMARI	GO:0005230	extracellular ligand-gated ion channel activity	Gains
SMARI	GO:0005261	cation channel activity	Gains
SMARI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
SMARI	GO:0022834	ligand-gated channel activity	Gains
SMARI	GO:0015276	ligand-gated ion channel activity	Gains
SMARI	GO:0015075	ion transmembrane transporter activity	Gains
SMARI	GO:0022857	transmembrane transporter activity	Gains
SMARI	GO:0003676	nucleic acid binding	Gains
SMARI	GO:0022891	substrate-specific transmembrane transporter activity	Gains
SMARI	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
SMARI	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
SMARI	GO:0004888	transmembrane signaling receptor activity	Gains
SMARI	GO:0004803	transposase activity	Gains
SMARI	GO:0046914	transition metal ion binding	Gains
SMARI	GO:0016779	nucleotidyltransferase activity	Gains
SMARI	GO:0008527	taste receptor activity	Gains
SMARI	GO:0046873	metal ion transmembrane transporter activity	Gains
SMARI	GO:0008270	zinc ion binding	Gains
SMARI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
SMARI	GO:0060089	molecular transducer activity	Gains
SMARI	GO:0008134	transcription factor binding	Gains
SMARI	GO:0022836	gated channel activity	Gains
SMARI	GO:0004872	receptor activity	Gains
SMARI	GO:0008192	RNA guanylyltransferase activity	Gains
SMARI	GO:0022890	inorganic cation transmembrane transporter activity	Gains
SMARI	GO:0038023	signaling receptor activity	Gains
SMARI	GO:0008453	alanine-glyoxylate transaminase activity	Gains
SMARI	GO:0005343	organic acid:sodium symporter activity	Gains
SMARI	GO:0030246	carbohydrate binding	Gains
SMARI	GO:0046872	metal ion binding	Gains
SMARI	GO:0022892	substrate-specific transporter activity	Gains
SMARI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
SMARI	GO:0001091	RNA polymerase II basal transcription factor binding	Gains
SMARI	GO:0001098	basal transcription machinery binding	Gains
SMARI	GO:0001099	basal RNA polymerase II transcription machinery binding	Gains
SMARI	GO:0003960	NADPH:quinone reductase activity	Gains
SMARI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
SMARI	GO:0004175	endopeptidase activity	Gains
SMARI	GO:0043169	cation binding	Gains
SMARI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
SMARI	GO:0003727	single-stranded RNA binding	Gains
SMARI	GO:0017153	sodium:dicarboxylate symporter activity	Gains
SMARI	GO:0004484	mRNA guanylyltransferase activity	Gains
SMARI	GO:0035173	histone kinase activity	Gains
SMARI	GO:0004521	endoribonuclease activity	Gains
SMARI	GO:0008324	cation transmembrane transporter activity	Gains
SMARI	GO:0008066	glutamate receptor activity	Gains
SMARI	GO:0001085	RNA polymerase II transcription factor binding	Gains
SMARI	GO:0005549	odorant binding	Gains
SMARI	GO:0004519	endonuclease activity	Gains
SMARI	GO:0004930	G-protein coupled receptor activity	Gains
SMARI	GO:0005215	transporter activity	Gains
SMARI	GO:0004970	ionotropic glutamate receptor activity	Gains
SMARI	GO:0022824	transmitter-gated ion channel activity	Gains
SMARI	GO:0022835	transmitter-gated channel activity	Gains
SMARI	GO:0004871	signal transducer activity	Gains
SMARI	GO:0043023	ribosomal large subunit binding	Gains
SMARI	GO:0001096	TFIIF-class transcription factor binding	Gains
SMARI	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
SMARI	GO:0035174	histone serine kinase activity	Gains
SMARI	GO:0008504	monoamine transmembrane transporter activity	Gains
SMARI	GO:0004984	olfactory receptor activity	Gains
SMARI	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
SMARI	GO:0005381	iron ion transmembrane transporter activity	Gains
SMARI	GO:0070568	guanylyltransferase activity	Gains
SMARI	GO:0009881	photoreceptor activity	Losses
SMARI	GO:0005198	structural molecule activity	Losses
SMARI	GO:0003735	structural constituent of ribosome	Losses
SMARI	GO:0008083	growth factor activity	Losses
SMARI	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	Losses
SMARI	GO:0005245	voltage-gated calcium channel activity	Losses
SMARI	GO:0008020	G-protein coupled photoreceptor activity	Losses
SMARI	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
SMARI	GO:0004950	chemokine receptor activity	Losses
SMARI	GO:0043958	acryloyl-CoA reductase activity	Losses
SMARI	GO:0015928	fucosidase activity	Losses
SMARI	GO:0043874	acireductone synthase activity	Losses
SMARI	GO:0004560	alpha-L-fucosidase activity	Losses
SMARI	GO:0003913	DNA photolyase activity	Losses
SMARI	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
SMARI	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Losses
SMARI	GO:0005549	odorant binding	Losses
SMARI	GO:0042302	structural constituent of cuticle	Losses
SMARI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
SMARI	GO:0005121	Toll binding	Losses
SMARI	GO:0019843	rRNA binding	Losses
SMARI	GO:0043024	ribosomal small subunit binding	Losses
SMARI	GO:0004896	cytokine receptor activity	Losses
SMARI	GO:0050113	inositol oxygenase activity	Losses
SMARI	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
SMARI	GO:0005262	calcium channel activity	Losses
SMARI	GO:0005516	calmodulin binding	Losses
SMARI	GO:1904680	peptide transmembrane transporter activity	Losses
SMARI	GO:0042887	amide transmembrane transporter activity	Losses
SMARI	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
SMARI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
SMARI	GO:0070330	aromatase activity	Losses
SMARI	GO:0016791	phosphatase activity	Losses
SMARI	GO:0047915	ganglioside galactosyltransferase activity	Losses
SMARI	GO:0005214	structural constituent of chitin-based cuticle	Losses
SMARI	GO:0004602	glutathione peroxidase activity	Losses
SMARI	GO:0036442	hydrogen-exporting ATPase activity	Losses
SMARI	GO:0046983	protein dimerization activity	Losses
SMARI	GO:0004983	neuropeptide Y receptor activity	Losses
SMARI	GO:0003735	structural constituent of ribosome	Extinctions
SMARI	GO:0005198	structural molecule activity	Extinctions
SMARI	GO:0042302	structural constituent of cuticle	Extinctions
SMARI	GO:0008020	G-protein coupled photoreceptor activity	Extinctions
SMARI	GO:0003913	DNA photolyase activity	Extinctions
SMARI	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
SMARI	GO:0009881	photoreceptor activity	Extinctions
SMARI	GO:0019843	rRNA binding	Extinctions
SMARI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
SMARI	GO:0043024	ribosomal small subunit binding	Extinctions
SMARI	GO:0050113	inositol oxygenase activity	Extinctions
SMARI	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Extinctions
SMARI	GO:1904680	peptide transmembrane transporter activity	Extinctions
SMARI	GO:0042887	amide transmembrane transporter activity	Extinctions
SMARI	GO:0005214	structural constituent of chitin-based cuticle	Extinctions
SMARI	GO:0003954	NADH dehydrogenase activity	Extinctions
SMARI	GO:0003723	RNA binding	Extinctions
SMARI	GO:0008010	structural constituent of chitin-based larval cuticle	Extinctions
SMARI	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Extinctions
SMARI	GO:0051861	glycolipid binding	Extinctions
SMARI	GO:0004045	aminoacyl-tRNA hydrolase activity	Extinctions
SMARI	GO:0099528	G-protein coupled neurotransmitter receptor activity	Extinctions
SMARI	GO:0015464	acetylcholine receptor activity	Extinctions
SMARI	GO:0016907	G-protein coupled acetylcholine receptor activity	Extinctions
SMARI	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Extinctions
SMARI	GO:0046982	protein heterodimerization activity	Extinctions
SMARI	GO:0008320	protein transmembrane transporter activity	Extinctions
ISCAP	GO:0004497	monooxygenase activity	Gains
ISCAP	GO:0070330	aromatase activity	Gains
ISCAP	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
ISCAP	GO:0004930	G-protein coupled receptor activity	Gains
ISCAP	GO:0005506	iron ion binding	Gains
ISCAP	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
ISCAP	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
ISCAP	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
ISCAP	GO:0004888	transmembrane signaling receptor activity	Gains
ISCAP	GO:0020037	heme binding	Gains
ISCAP	GO:0008528	G-protein coupled peptide receptor activity	Gains
ISCAP	GO:0001653	peptide receptor activity	Gains
ISCAP	GO:0004312	fatty acid synthase activity	Gains
ISCAP	GO:0046906	tetrapyrrole binding	Gains
ISCAP	GO:0015370	solute:sodium symporter activity	Gains
ISCAP	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
ISCAP	GO:0038023	signaling receptor activity	Gains
ISCAP	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
ISCAP	GO:0005328	neurotransmitter:sodium symporter activity	Gains
ISCAP	GO:0004866	endopeptidase inhibitor activity	Gains
ISCAP	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
ISCAP	GO:0099600	transmembrane receptor activity	Gains
ISCAP	GO:0005326	neurotransmitter transporter activity	Gains
ISCAP	GO:0008188	neuropeptide receptor activity	Gains
ISCAP	GO:0061134	peptidase regulator activity	Gains
ISCAP	GO:0016878	acid-thiol ligase activity	Gains
ISCAP	GO:0061135	endopeptidase regulator activity	Gains
ISCAP	GO:0030414	peptidase inhibitor activity	Gains
ISCAP	GO:0045289	luciferin monooxygenase activity	Gains
ISCAP	GO:0015645	fatty acid ligase activity	Gains
ISCAP	GO:0030060	L-malate dehydrogenase activity	Gains
ISCAP	GO:0008519	ammonium transmembrane transporter activity	Gains
ISCAP	GO:0016418	S-acetyltransferase activity	Gains
ISCAP	GO:0042302	structural constituent of cuticle	Gains
ISCAP	GO:0004180	carboxypeptidase activity	Gains
ISCAP	GO:0015294	solute:cation symporter activity	Gains
ISCAP	GO:0004896	cytokine receptor activity	Gains
ISCAP	GO:0005000	vasopressin receptor activity	Gains
ISCAP	GO:0140103	catalytic activity, acting on a glycoprotein	Gains
ISCAP	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
ISCAP	GO:0015293	symporter activity	Gains
ISCAP	GO:0004871	signal transducer activity	Gains
ISCAP	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
ISCAP	GO:0016405	CoA-ligase activity	Gains
ISCAP	GO:0004872	receptor activity	Gains
ISCAP	GO:0008417	fucosyltransferase activity	Gains
ISCAP	GO:0008233	peptidase activity	Gains
ISCAP	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
ISCAP	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
ISCAP	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
ISCAP	GO:0004857	enzyme inhibitor activity	Gains
ISCAP	GO:0060089	molecular transducer activity	Gains
ISCAP	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
ISCAP	GO:0008146	sulfotransferase activity	Gains
ISCAP	GO:0016209	antioxidant activity	Gains
ISCAP	GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
ISCAP	GO:0034481	chondroitin sulfotransferase activity	Gains
ISCAP	GO:0050591	quinine 3-monooxygenase activity	Gains
ISCAP	GO:0016413	O-acetyltransferase activity	Gains
ISCAP	GO:0016855	racemase and epimerase activity, acting on amino acids and derivatives	Gains
ISCAP	GO:0008484	sulfuric ester hydrolase activity	Gains
ISCAP	GO:0004784	superoxide dismutase activity	Gains
ISCAP	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Gains
ISCAP	GO:0016615	malate dehydrogenase activity	Gains
ISCAP	GO:0004364	glutathione transferase activity	Gains
ISCAP	GO:0015081	sodium ion transmembrane transporter activity	Gains
ISCAP	GO:0004411	homogentisate 1,2-dioxygenase activity	Gains
ISCAP	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Gains
ISCAP	GO:0003884	D-amino-acid oxidase activity	Gains
ISCAP	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
ISCAP	GO:0004796	thromboxane-A synthase activity	Gains
ISCAP	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Gains
ISCAP	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Gains
ISCAP	GO:0004560	alpha-L-fucosidase activity	Gains
ISCAP	GO:0004611	phosphoenolpyruvate carboxykinase activity	Gains
ISCAP	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
ISCAP	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
ISCAP	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
ISCAP	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Gains
ISCAP	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
ISCAP	GO:0042586	peptide deformylase activity	Gains
ISCAP	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
ISCAP	GO:0004054	arginine kinase activity	Gains
ISCAP	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Gains
ISCAP	GO:0004950	chemokine receptor activity	Gains
ISCAP	GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Gains
ISCAP	GO:0046922	peptide-O-fucosyltransferase activity	Gains
ISCAP	GO:0016505	peptidase activator activity involved in apoptotic process	Gains
ISCAP	GO:0015922	aspartate oxidase activity	Gains
ISCAP	GO:0015928	fucosidase activity	Gains
ISCAP	GO:0097003	adipokinetic hormone receptor activity	Gains
ISCAP	GO:0097004	adipokinetic hormone binding	Gains
ISCAP	GO:0008445	D-aspartate oxidase activity	Gains
ISCAP	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
ISCAP	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
ISCAP	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
ISCAP	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
ISCAP	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
ISCAP	GO:0004602	glutathione peroxidase activity	Gains
ISCAP	GO:0016787	hydrolase activity	Gains
ISCAP	GO:0003960	NADPH:quinone reductase activity	Gains
ISCAP	GO:0005549	odorant binding	Gains
ISCAP	GO:0022824	transmitter-gated ion channel activity	Gains
ISCAP	GO:0022835	transmitter-gated channel activity	Gains
ISCAP	GO:0004970	ionotropic glutamate receptor activity	Gains
ISCAP	GO:0005337	nucleoside transmembrane transporter activity	Gains
ISCAP	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	Gains
ISCAP	GO:0005344	oxygen carrier activity	Gains
ISCAP	GO:0016491	oxidoreductase activity	Gains
ISCAP	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
ISCAP	GO:0004984	olfactory receptor activity	Gains
ISCAP	GO:0005343	organic acid:sodium symporter activity	Gains
ISCAP	GO:0004222	metalloendopeptidase activity	Gains
ISCAP	GO:0005515	protein binding	Losses
ISCAP	GO:0003964	RNA-directed DNA polymerase activity	Losses
ISCAP	GO:0034061	DNA polymerase activity	Losses
ISCAP	GO:0005488	binding	Losses
ISCAP	GO:0140097	catalytic activity, acting on DNA	Losses
ISCAP	GO:0016779	nucleotidyltransferase activity	Losses
ISCAP	GO:0008017	microtubule binding	Losses
ISCAP	GO:0015631	tubulin binding	Losses
ISCAP	GO:0003995	acyl-CoA dehydrogenase activity	Losses
ISCAP	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
ISCAP	GO:0016597	amino acid binding	Losses
ISCAP	GO:0008092	cytoskeletal protein binding	Losses
ISCAP	GO:0004418	hydroxymethylbilane synthase activity	Losses
ISCAP	GO:0000182	rDNA binding	Losses
ISCAP	GO:0004852	uroporphyrinogen-III synthase activity	Losses
ISCAP	GO:0070853	myosin VI binding	Losses
ISCAP	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Losses
ISCAP	GO:0005315	inorganic phosphate transmembrane transporter activity	Losses
ISCAP	GO:0004190	aspartic-type endopeptidase activity	Losses
ISCAP	GO:0070001	aspartic-type peptidase activity	Losses
ISCAP	GO:0016835	carbon-oxygen lyase activity	Losses
ISCAP	GO:0019787	ubiquitin-like protein transferase activity	Losses
ISCAP	GO:0008568	microtubule-severing ATPase activity	Losses
ISCAP	GO:0030674	protein binding, bridging	Losses
ISCAP	GO:0008233	peptidase activity	Losses
ISCAP	GO:0004004	ATP-dependent RNA helicase activity	Losses
ISCAP	GO:0003796	lysozyme activity	Losses
ISCAP	GO:0004175	endopeptidase activity	Losses
ISCAP	GO:0017016	Ras GTPase binding	Losses
ISCAP	GO:0019899	enzyme binding	Losses
ISCAP	GO:0004842	ubiquitin-protein transferase activity	Losses
ISCAP	GO:0031267	small GTPase binding	Losses
ISCAP	GO:0008186	RNA-dependent ATPase activity	Losses
ISCAP	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
ISCAP	GO:0004803	transposase activity	Losses
ISCAP	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Losses
ISCAP	GO:0000340	RNA 7-methylguanosine cap binding	Losses
ISCAP	GO:0003696	satellite DNA binding	Losses
ISCAP	GO:0001103	RNA polymerase II repressing transcription factor binding	Losses
ISCAP	GO:0004736	pyruvate carboxylase activity	Losses
ISCAP	GO:0043167	ion binding	Losses
ISCAP	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
ISCAP	GO:0008270	zinc ion binding	Losses
ISCAP	GO:0061783	peptidoglycan muralytic activity	Losses
ISCAP	GO:0046914	transition metal ion binding	Losses
ISCAP	GO:0005102	receptor binding	Losses
ISCAP	GO:0017048	Rho GTPase binding	Losses
ISCAP	GO:0004869	cysteine-type endopeptidase inhibitor activity	Extinctions
ISCAP	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
ISCAP	GO:0004418	hydroxymethylbilane synthase activity	Extinctions
ISCAP	GO:0004852	uroporphyrinogen-III synthase activity	Extinctions
ISCAP	GO:0005488	binding	Extinctions
ISCAP	GO:0004842	ubiquitin-protein transferase activity	Extinctions
ISCAP	GO:0004004	ATP-dependent RNA helicase activity	Extinctions
ISCAP	GO:0008186	RNA-dependent ATPase activity	Extinctions
ISCAP	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	Extinctions
ISCAP	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
ISCAP	GO:0017016	Ras GTPase binding	Extinctions
ISCAP	GO:0031267	small GTPase binding	Extinctions
ISCAP	GO:0140097	catalytic activity, acting on DNA	Extinctions
ISCAP	GO:0097472	cyclin-dependent protein kinase activity	Extinctions
ISCAP	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Extinctions
ISCAP	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Extinctions
ISCAP	GO:0003724	RNA helicase activity	Extinctions
ISCAP	GO:0019899	enzyme binding	Extinctions
ISCAP	GO:0004601	peroxidase activity	Extinctions
ISCAP	GO:0008568	microtubule-severing ATPase activity	Extinctions
COBSC	GO:0003676	nucleic acid binding	Gains
COBSC	GO:0003964	RNA-directed DNA polymerase activity	Gains
COBSC	GO:0034061	DNA polymerase activity	Gains
COBSC	GO:0016779	nucleotidyltransferase activity	Gains
COBSC	GO:1901363	heterocyclic compound binding	Gains
COBSC	GO:0097159	organic cyclic compound binding	Gains
COBSC	GO:0140097	catalytic activity, acting on DNA	Gains
COBSC	GO:0003723	RNA binding	Gains
COBSC	GO:0005488	binding	Gains
COBSC	GO:0004190	aspartic-type endopeptidase activity	Gains
COBSC	GO:0070001	aspartic-type peptidase activity	Gains
COBSC	GO:0003677	DNA binding	Gains
COBSC	GO:0046914	transition metal ion binding	Gains
COBSC	GO:0008270	zinc ion binding	Gains
COBSC	GO:0005198	structural molecule activity	Gains
COBSC	GO:0046872	metal ion binding	Gains
COBSC	GO:0043169	cation binding	Gains
COBSC	GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	Gains
COBSC	GO:0003774	motor activity	Gains
COBSC	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
COBSC	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Gains
COBSC	GO:0097747	RNA polymerase activity	Gains
COBSC	GO:0003777	microtubule motor activity	Gains
COBSC	GO:0034062	5'-3' RNA polymerase activity	Gains
COBSC	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	Gains
COBSC	GO:0003696	satellite DNA binding	Gains
COBSC	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
COBSC	GO:0005201	extracellular matrix structural constituent	Gains
COBSC	GO:0004984	olfactory receptor activity	Gains
COBSC	GO:0003887	DNA-directed DNA polymerase activity	Gains
COBSC	GO:0035251	UDP-glucosyltransferase activity	Gains
COBSC	GO:0004500	dopamine beta-monooxygenase activity	Gains
COBSC	GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
COBSC	GO:0061659	ubiquitin-like protein ligase activity	Gains
COBSC	GO:0061630	ubiquitin protein ligase activity	Gains
COBSC	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
COBSC	GO:0019203	carbohydrate phosphatase activity	Gains
COBSC	GO:0004563	beta-N-acetylhexosaminidase activity	Gains
COBSC	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
COBSC	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
COBSC	GO:0003964	RNA-directed DNA polymerase activity	Losses
COBSC	GO:0005216	ion channel activity	Losses
COBSC	GO:0022838	substrate-specific channel activity	Losses
COBSC	GO:0004984	olfactory receptor activity	Losses
COBSC	GO:0015267	channel activity	Losses
COBSC	GO:0022803	passive transmembrane transporter activity	Losses
COBSC	GO:0005549	odorant binding	Losses
COBSC	GO:0005261	cation channel activity	Losses
COBSC	GO:0015075	ion transmembrane transporter activity	Losses
COBSC	GO:0022857	transmembrane transporter activity	Losses
COBSC	GO:0022843	voltage-gated cation channel activity	Losses
COBSC	GO:0022836	gated channel activity	Losses
COBSC	GO:0034061	DNA polymerase activity	Losses
COBSC	GO:0005262	calcium channel activity	Losses
COBSC	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
COBSC	GO:0022891	substrate-specific transmembrane transporter activity	Losses
COBSC	GO:0046873	metal ion transmembrane transporter activity	Losses
COBSC	GO:0008081	phosphoric diester hydrolase activity	Losses
COBSC	GO:0005215	transporter activity	Losses
COBSC	GO:0016788	hydrolase activity, acting on ester bonds	Losses
COBSC	GO:0052745	inositol phosphate phosphatase activity	Losses
COBSC	GO:0016209	antioxidant activity	Losses
COBSC	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
COBSC	GO:0008445	D-aspartate oxidase activity	Losses
COBSC	GO:0043874	acireductone synthase activity	Losses
COBSC	GO:0018685	alkane 1-monooxygenase activity	Losses
COBSC	GO:0046423	allene-oxide cyclase activity	Losses
COBSC	GO:0050824	water binding	Losses
COBSC	GO:0050825	ice binding	Losses
COBSC	GO:0003884	D-amino-acid oxidase activity	Losses
COBSC	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
COBSC	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
COBSC	GO:0052834	inositol monophosphate phosphatase activity	Losses
COBSC	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
COBSC	GO:0015922	aspartate oxidase activity	Losses
COBSC	GO:0019789	SUMO transferase activity	Losses
COBSC	GO:0030553	cGMP binding	Losses
COBSC	GO:0005244	voltage-gated ion channel activity	Losses
COBSC	GO:0022832	voltage-gated channel activity	Losses
COBSC	GO:0008509	anion transmembrane transporter activity	Losses
COBSC	GO:0016779	nucleotidyltransferase activity	Losses
COBSC	GO:0004620	phospholipase activity	Losses
COBSC	GO:0005506	iron ion binding	Losses
COBSC	GO:0022890	inorganic cation transmembrane transporter activity	Losses
COBSC	GO:0016298	lipase activity	Losses
COBSC	GO:0015276	ligand-gated ion channel activity	Losses
COBSC	GO:0022834	ligand-gated channel activity	Losses
COBSC	GO:0022892	substrate-specific transporter activity	Losses
COBSC	GO:0030246	carbohydrate binding	Losses
COBSC	GO:0004518	nuclease activity	Losses
COBSC	GO:0015103	inorganic anion transmembrane transporter activity	Losses
COBSC	GO:0016491	oxidoreductase activity	Losses
COBSC	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
COBSC	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Losses
COBSC	GO:0005385	zinc ion transmembrane transporter activity	Losses
COBSC	GO:0004950	chemokine receptor activity	Losses
COBSC	GO:0016530	metallochaperone activity	Losses
COBSC	GO:0004930	G-protein coupled receptor activity	Losses
COBSC	GO:0004364	glutathione transferase activity	Losses
COBSC	GO:0005245	voltage-gated calcium channel activity	Losses
COBSC	GO:0140102	catalytic activity, acting on a rRNA	Losses
COBSC	GO:0008649	rRNA methyltransferase activity	Losses
COBSC	GO:0099600	transmembrane receptor activity	Losses
COBSC	GO:0008324	cation transmembrane transporter activity	Losses
COBSC	GO:0140097	catalytic activity, acting on DNA	Losses
COBSC	GO:0099094	ligand-gated cation channel activity	Losses
COBSC	GO:0015085	calcium ion transmembrane transporter activity	Losses
COBSC	GO:0004190	aspartic-type endopeptidase activity	Losses
COBSC	GO:0070001	aspartic-type peptidase activity	Losses
COBSC	GO:0004692	cGMP-dependent protein kinase activity	Losses
COBSC	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
COBSC	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
COBSC	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
COBSC	GO:0005217	intracellular ligand-gated ion channel activity	Losses
COBSC	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Losses
COBSC	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
COBSC	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
COBSC	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Losses
COBSC	GO:0004784	superoxide dismutase activity	Losses
COBSC	GO:0004896	cytokine receptor activity	Losses
COBSC	GO:0030551	cyclic nucleotide binding	Losses
COBSC	GO:0005230	extracellular ligand-gated ion channel activity	Losses
COBSC	GO:0016860	intramolecular oxidoreductase activity	Losses
COBSC	GO:0015079	potassium ion transmembrane transporter activity	Losses
COBSC	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
COBSC	GO:0016853	isomerase activity	Losses
COBSC	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
COBSC	GO:0005267	potassium channel activity	Losses
COBSC	GO:0005272	sodium channel activity	Losses
COBSC	GO:0005549	odorant binding	Extinctions
COBSC	GO:0004984	olfactory receptor activity	Extinctions
COBSC	GO:0008445	D-aspartate oxidase activity	Extinctions
COBSC	GO:0050824	water binding	Extinctions
COBSC	GO:0050825	ice binding	Extinctions
COBSC	GO:0003884	D-amino-acid oxidase activity	Extinctions
COBSC	GO:0015922	aspartate oxidase activity	Extinctions
COBSC	GO:0019789	SUMO transferase activity	Extinctions
COBSC	GO:0140102	catalytic activity, acting on a rRNA	Extinctions
COBSC	GO:0008649	rRNA methyltransferase activity	Extinctions
COBSC	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
COBSC	GO:0005385	zinc ion transmembrane transporter activity	Extinctions
COBSC	GO:0016530	metallochaperone activity	Extinctions
COBSC	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Extinctions
COBSC	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Extinctions
COBSC	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Extinctions
COBSC	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Extinctions
COBSC	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Extinctions
COBSC	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Extinctions
COBSC	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Extinctions
COBSC	GO:0004784	superoxide dismutase activity	Extinctions
COBSC	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
COBSC	GO:0008081	phosphoric diester hydrolase activity	Extinctions
COBSC	GO:0016835	carbon-oxygen lyase activity	Extinctions
COBSC	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	Extinctions
COBSC	GO:0004322	ferroxidase activity	Extinctions
COBSC	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Extinctions
COBSC	GO:0008859	exoribonuclease II activity	Extinctions
COBSC	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	Extinctions
COBSC	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	Extinctions
COBSC	GO:0004551	nucleotide diphosphatase activity	Extinctions
COBSC	GO:0016836	hydro-lyase activity	Extinctions
COBSC	GO:0016433	rRNA (adenine) methyltransferase activity	Extinctions
COBSC	GO:0032266	phosphatidylinositol-3-phosphate binding	Extinctions
HY11	GO:0005549	odorant binding	Gains
HY11	GO:0004984	olfactory receptor activity	Gains
HY11	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
HY11	GO:0004871	signal transducer activity	Gains
HY11	GO:0061783	peptidoglycan muralytic activity	Gains
HY11	GO:0038023	signaling receptor activity	Gains
HY11	GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
HY11	GO:0016215	acyl-CoA desaturase activity	Gains
HY11	GO:0099600	transmembrane receptor activity	Gains
HY11	GO:0004872	receptor activity	Gains
HY11	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
HY11	GO:0004888	transmembrane signaling receptor activity	Gains
HY11	GO:0060089	molecular transducer activity	Gains
HY11	GO:0015295	solute:proton symporter activity	Gains
HY11	GO:0005351	sugar:proton symporter activity	Gains
HY11	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
HY11	GO:0005402	cation:sugar symporter activity	Gains
HY11	GO:0004930	G-protein coupled receptor activity	Gains
HY11	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
HY11	GO:0004712	protein serine/threonine/tyrosine kinase activity	Gains
HY11	GO:0015144	carbohydrate transmembrane transporter activity	Gains
HY11	GO:0051119	sugar transmembrane transporter activity	Gains
HY11	GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
HY11	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Gains
HY11	GO:0070735	protein-glycine ligase activity	Gains
HY11	GO:0070736	protein-glycine ligase activity, initiating	Gains
HY11	GO:0070737	protein-glycine ligase activity, elongating	Gains
HY11	GO:0016018	cyclosporin A binding	Gains
HY11	GO:0016019	peptidoglycan receptor activity	Gains
HY11	GO:0050093	methanol dehydrogenase activity	Gains
HY11	GO:0001875	lipopolysaccharide receptor activity	Gains
HY11	GO:0032500	muramyl dipeptide binding	Gains
HY11	GO:0047886	farnesol dehydrogenase activity	Gains
HY11	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Gains
HY11	GO:0047623	adenosine-phosphate deaminase activity	Gains
HY11	GO:0046332	SMAD binding	Gains
HY11	GO:0050480	imidazolonepropionase activity	Gains
HY11	GO:0004971	AMPA glutamate receptor activity	Gains
HY11	GO:0070379	high mobility group box 1 binding	Gains
HY11	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Gains
HY11	GO:0017159	pantetheine hydrolase activity	Gains
HY11	GO:0070410	co-SMAD binding	Gains
HY11	GO:0003876	AMP deaminase activity	Gains
HY11	GO:0003844	1,4-alpha-glucan branching enzyme activity	Gains
HY11	GO:0042277	peptide binding	Gains
HY11	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
HY11	GO:0005230	extracellular ligand-gated ion channel activity	Gains
HY11	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
HY11	GO:0000156	phosphorelay response regulator activity	Gains
HY11	GO:0031386	protein tag	Gains
HY11	GO:0009882	blue light photoreceptor activity	Gains
HY11	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Gains
HY11	GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
HY11	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
HY11	GO:0033218	amide binding	Gains
HY11	GO:0050660	flavin adenine dinucleotide binding	Gains
HY11	GO:0022834	ligand-gated channel activity	Gains
HY11	GO:0015276	ligand-gated ion channel activity	Gains
HY11	GO:0015294	solute:cation symporter activity	Gains
HY11	GO:0022836	gated channel activity	Gains
HY11	GO:0038187	pattern recognition receptor activity	Gains
HY11	GO:0008329	signaling pattern recognition receptor activity	Gains
HY11	GO:0004040	amidase activity	Gains
HY11	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Gains
HY11	GO:0005118	sevenless binding	Gains
HY11	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Gains
HY11	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
HY11	GO:0019107	myristoyltransferase activity	Gains
HY11	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY11	GO:0034061	DNA polymerase activity	Losses
HY11	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY11	GO:0140097	catalytic activity, acting on DNA	Losses
HY11	GO:0016779	nucleotidyltransferase activity	Losses
HY11	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HY11	GO:0004984	olfactory receptor activity	Losses
HY11	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HY11	GO:0004519	endonuclease activity	Losses
HY11	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
HY11	GO:0046914	transition metal ion binding	Losses
HY11	GO:0004521	endoribonuclease activity	Losses
HY11	GO:0004518	nuclease activity	Losses
HY11	GO:0004312	fatty acid synthase activity	Losses
HY11	GO:0005549	odorant binding	Losses
HY11	GO:0001222	transcription corepressor binding	Losses
HY11	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
HY11	GO:0008986	pyruvate, water dikinase activity	Losses
HY11	GO:0018833	DDT-dehydrochlorinase activity	Losses
HY11	GO:0047536	2-aminoadipate transaminase activity	Losses
HY11	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
HY11	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
HY11	GO:0008270	zinc ion binding	Losses
HY11	GO:0008233	peptidase activity	Losses
HY11	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
HY11	GO:0004540	ribonuclease activity	Losses
HY11	GO:0003723	RNA binding	Losses
HY11	GO:0001221	transcription cofactor binding	Losses
HY11	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
HY11	GO:0004555	alpha,alpha-trehalase activity	Losses
HY11	GO:0016781	phosphotransferase activity, paired acceptors	Losses
HY11	GO:0016848	carbon-halide lyase activity	Losses
HY11	GO:0015927	trehalase activity	Losses
HY11	GO:0004348	glucosylceramidase activity	Losses
HY11	GO:0070001	aspartic-type peptidase activity	Losses
HY11	GO:0004190	aspartic-type endopeptidase activity	Losses
HY11	GO:0004930	G-protein coupled receptor activity	Losses
HY11	GO:0032794	GTPase activating protein binding	Losses
HY11	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
HY11	GO:0097157	pre-mRNA intronic binding	Losses
HY11	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
HY11	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
HY11	GO:0003676	nucleic acid binding	Losses
HY11	GO:0031683	G-protein beta/gamma-subunit complex binding	Losses
HY11	GO:0034450	ubiquitin-ubiquitin ligase activity	Losses
HY11	GO:0030215	semaphorin receptor binding	Losses
HY11	GO:0061659	ubiquitin-like protein ligase activity	Losses
HY11	GO:0061630	ubiquitin protein ligase activity	Losses
HY11	GO:0048365	Rac GTPase binding	Losses
HY11	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
HY11	GO:0036002	pre-mRNA binding	Losses
HY11	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
HY11	GO:0004322	ferroxidase activity	Losses
HY11	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
HY11	GO:0004888	transmembrane signaling receptor activity	Losses
HY11	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY11	GO:0034061	DNA polymerase activity	Extinctions
HY11	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY11	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
HY11	GO:0016779	nucleotidyltransferase activity	Extinctions
HY11	GO:0008986	pyruvate, water dikinase activity	Extinctions
HY11	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
HY11	GO:0003723	RNA binding	Extinctions
HY11	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
HY11	GO:0016781	phosphotransferase activity, paired acceptors	Extinctions
HY11	GO:0004521	endoribonuclease activity	Extinctions
HY11	GO:0003676	nucleic acid binding	Extinctions
HY11	GO:0097157	pre-mRNA intronic binding	Extinctions
HY11	GO:0034450	ubiquitin-ubiquitin ligase activity	Extinctions
HY11	GO:0030215	semaphorin receptor binding	Extinctions
HY11	GO:0061659	ubiquitin-like protein ligase activity	Extinctions
HY11	GO:0061630	ubiquitin protein ligase activity	Extinctions
HY11	GO:0048365	Rac GTPase binding	Extinctions
HY11	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Extinctions
HY11	GO:0036002	pre-mRNA binding	Extinctions
HY11	GO:0004540	ribonuclease activity	Extinctions
HY11	GO:0004803	transposase activity	Extinctions
HY11	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
HY11	GO:0004519	endonuclease activity	Extinctions
HY11	GO:1901363	heterocyclic compound binding	Extinctions
HY11	GO:0097159	organic cyclic compound binding	Extinctions
HY11	GO:0046914	transition metal ion binding	Extinctions
HY11	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Extinctions
DPLEX	GO:0003964	RNA-directed DNA polymerase activity	Gains
DPLEX	GO:0034061	DNA polymerase activity	Gains
DPLEX	GO:0016779	nucleotidyltransferase activity	Gains
DPLEX	GO:0004519	endonuclease activity	Gains
DPLEX	GO:0140097	catalytic activity, acting on DNA	Gains
DPLEX	GO:0004518	nuclease activity	Gains
DPLEX	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
DPLEX	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
DPLEX	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DPLEX	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
DPLEX	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DPLEX	GO:0016740	transferase activity	Gains
DPLEX	GO:0070279	vitamin B6 binding	Gains
DPLEX	GO:0030170	pyridoxal phosphate binding	Gains
DPLEX	GO:0003993	acid phosphatase activity	Gains
DPLEX	GO:0022834	ligand-gated channel activity	Gains
DPLEX	GO:0015276	ligand-gated ion channel activity	Gains
DPLEX	GO:0019842	vitamin binding	Gains
DPLEX	GO:0004521	endoribonuclease activity	Gains
DPLEX	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
DPLEX	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
DPLEX	GO:0016788	hydrolase activity, acting on ester bonds	Gains
DPLEX	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
DPLEX	GO:0005216	ion channel activity	Gains
DPLEX	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
DPLEX	GO:0008273	calcium, potassium:sodium antiporter activity	Gains
DPLEX	GO:0004499	N,N-dimethylaniline monooxygenase activity	Gains
DPLEX	GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
DPLEX	GO:0045159	myosin II binding	Gains
DPLEX	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
DPLEX	GO:0022838	substrate-specific channel activity	Gains
DPLEX	GO:0048037	cofactor binding	Gains
DPLEX	GO:0022836	gated channel activity	Gains
DPLEX	GO:0022803	passive transmembrane transporter activity	Gains
DPLEX	GO:0015267	channel activity	Gains
DPLEX	GO:0016832	aldehyde-lyase activity	Gains
DPLEX	GO:0020037	heme binding	Gains
DPLEX	GO:0061783	peptidoglycan muralytic activity	Gains
DPLEX	GO:0099600	transmembrane receptor activity	Gains
DPLEX	GO:0046906	tetrapyrrole binding	Gains
DPLEX	GO:0004984	olfactory receptor activity	Gains
DPLEX	GO:0003824	catalytic activity	Gains
DPLEX	GO:0005506	iron ion binding	Gains
DPLEX	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
DPLEX	GO:0004033	aldo-keto reductase (NADP) activity	Gains
DPLEX	GO:0030898	actin-dependent ATPase activity	Gains
DPLEX	GO:0005487	nucleocytoplasmic transporter activity	Gains
DPLEX	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
DPLEX	GO:0022821	potassium ion antiporter activity	Gains
DPLEX	GO:0032296	double-stranded RNA-specific ribonuclease activity	Gains
DPLEX	GO:0019825	oxygen binding	Gains
DPLEX	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
DPLEX	GO:0004525	ribonuclease III activity	Gains
DPLEX	GO:0004872	receptor activity	Losses
DPLEX	GO:0004888	transmembrane signaling receptor activity	Losses
DPLEX	GO:0099600	transmembrane receptor activity	Losses
DPLEX	GO:0038023	signaling receptor activity	Losses
DPLEX	GO:0060089	molecular transducer activity	Losses
DPLEX	GO:0004930	G-protein coupled receptor activity	Losses
DPLEX	GO:0004871	signal transducer activity	Losses
DPLEX	GO:0004984	olfactory receptor activity	Losses
DPLEX	GO:0005549	odorant binding	Losses
DPLEX	GO:0008188	neuropeptide receptor activity	Losses
DPLEX	GO:0042834	peptidoglycan binding	Losses
DPLEX	GO:0008527	taste receptor activity	Losses
DPLEX	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
DPLEX	GO:0008020	G-protein coupled photoreceptor activity	Losses
DPLEX	GO:0005200	structural constituent of cytoskeleton	Losses
DPLEX	GO:0008528	G-protein coupled peptide receptor activity	Losses
DPLEX	GO:0001653	peptide receptor activity	Losses
DPLEX	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
DPLEX	GO:0042302	structural constituent of cuticle	Losses
DPLEX	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
DPLEX	GO:0050591	quinine 3-monooxygenase activity	Losses
DPLEX	GO:0016418	S-acetyltransferase activity	Losses
DPLEX	GO:0005214	structural constituent of chitin-based cuticle	Losses
DPLEX	GO:0042562	hormone binding	Losses
DPLEX	GO:0016500	protein-hormone receptor activity	Losses
DPLEX	GO:0009881	photoreceptor activity	Losses
DPLEX	GO:0005539	glycosaminoglycan binding	Losses
DPLEX	GO:0003682	chromatin binding	Losses
DPLEX	GO:0048365	Rac GTPase binding	Losses
DPLEX	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
DPLEX	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
DPLEX	GO:0004497	monooxygenase activity	Losses
DPLEX	GO:0020037	heme binding	Losses
DPLEX	GO:0046906	tetrapyrrole binding	Losses
DPLEX	GO:0005509	calcium ion binding	Losses
DPLEX	GO:0019199	transmembrane receptor protein kinase activity	Losses
DPLEX	GO:0051020	GTPase binding	Losses
DPLEX	GO:0008061	chitin binding	Losses
DPLEX	GO:0004781	sulfate adenylyltransferase (ATP) activity	Losses
DPLEX	GO:0004779	sulfate adenylyltransferase activity	Losses
DPLEX	GO:0017016	Ras GTPase binding	Losses
DPLEX	GO:0005198	structural molecule activity	Losses
DPLEX	GO:0004068	aspartate 1-decarboxylase activity	Losses
DPLEX	GO:0004020	adenylylsulfate kinase activity	Losses
DPLEX	GO:0008321	Ral guanyl-nucleotide exchange factor activity	Losses
DPLEX	GO:0035013	myosuppressin receptor activity	Losses
DPLEX	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
DPLEX	GO:0016503	pheromone receptor activity	Losses
DPLEX	GO:0048495	Roundabout binding	Losses
DPLEX	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Losses
DPLEX	GO:0004351	glutamate decarboxylase activity	Losses
DPLEX	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
DPLEX	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
DPLEX	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
DPLEX	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
DPLEX	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
DPLEX	GO:0047886	farnesol dehydrogenase activity	Losses
DPLEX	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
DPLEX	GO:0008747	N-acetylneuraminate lyase activity	Losses
DPLEX	GO:0032500	muramyl dipeptide binding	Losses
DPLEX	GO:0050431	transforming growth factor beta binding	Losses
DPLEX	GO:0004167	dopachrome isomerase activity	Losses
DPLEX	GO:0004139	deoxyribose-phosphate aldolase activity	Losses
DPLEX	GO:0016019	peptidoglycan receptor activity	Losses
DPLEX	GO:0050111	mycocerosate synthase activity	Losses
DPLEX	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
DPLEX	GO:0048763	calcium-induced calcium release activity	Losses
DPLEX	GO:0035274	diphenyl phthalate binding	Losses
DPLEX	GO:0035275	dibutyl phthalate binding	Losses
DPLEX	GO:0004782	sulfinoalanine decarboxylase activity	Losses
DPLEX	GO:0004720	protein-lysine 6-oxidase activity	Losses
DPLEX	GO:0015277	kainate selective glutamate receptor activity	Losses
DPLEX	GO:0016361	activin receptor activity, type I	Losses
DPLEX	GO:0004802	transketolase activity	Losses
DPLEX	GO:0000293	ferric-chelate reductase activity	Losses
DPLEX	GO:0036400	short neuropeptide F receptor activity	Losses
DPLEX	GO:0001875	lipopolysaccharide receptor activity	Losses
DPLEX	GO:0004587	ornithine-oxo-acid transaminase activity	Losses
DPLEX	GO:0003920	GMP reductase activity	Losses
DPLEX	GO:0008986	pyruvate, water dikinase activity	Losses
DPLEX	GO:0005025	transforming growth factor beta receptor activity, type I	Losses
DPLEX	GO:0005034	osmosensor activity	Losses
DPLEX	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
DPLEX	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
DPLEX	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
DPLEX	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
DPLEX	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
DPLEX	GO:0031267	small GTPase binding	Losses
DPLEX	GO:0099600	transmembrane receptor activity	Extinctions
DPLEX	GO:0004888	transmembrane signaling receptor activity	Extinctions
DPLEX	GO:0004872	receptor activity	Extinctions
DPLEX	GO:0008527	taste receptor activity	Extinctions
DPLEX	GO:0060089	molecular transducer activity	Extinctions
DPLEX	GO:0038023	signaling receptor activity	Extinctions
DPLEX	GO:0004930	G-protein coupled receptor activity	Extinctions
DPLEX	GO:0004871	signal transducer activity	Extinctions
DPLEX	GO:0004984	olfactory receptor activity	Extinctions
DPLEX	GO:0005549	odorant binding	Extinctions
DPLEX	GO:0003682	chromatin binding	Extinctions
DPLEX	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Extinctions
DPLEX	GO:0004022	alcohol dehydrogenase (NAD) activity	Extinctions
DPLEX	GO:0046873	metal ion transmembrane transporter activity	Extinctions
DPLEX	GO:0004020	adenylylsulfate kinase activity	Extinctions
DPLEX	GO:0008321	Ral guanyl-nucleotide exchange factor activity	Extinctions
DPLEX	GO:0048495	Roundabout binding	Extinctions
DPLEX	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Extinctions
DPLEX	GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
DPLEX	GO:0048763	calcium-induced calcium release activity	Extinctions
DPLEX	GO:0004720	protein-lysine 6-oxidase activity	Extinctions
DPLEX	GO:0000293	ferric-chelate reductase activity	Extinctions
DPLEX	GO:0004587	ornithine-oxo-acid transaminase activity	Extinctions
DPLEX	GO:0003920	GMP reductase activity	Extinctions
DPLEX	GO:0008986	pyruvate, water dikinase activity	Extinctions
DPLEX	GO:0005034	osmosensor activity	Extinctions
DPLEX	GO:0005200	structural constituent of cytoskeleton	Extinctions
DPLEX	GO:0004713	protein tyrosine kinase activity	Extinctions
DPLEX	GO:0005216	ion channel activity	Extinctions
DPLEX	GO:0009881	photoreceptor activity	Extinctions
DPLEX	GO:0022838	substrate-specific channel activity	Extinctions
DPLEX	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Extinctions
MROTU	GO:0003964	RNA-directed DNA polymerase activity	Gains
MROTU	GO:0034061	DNA polymerase activity	Gains
MROTU	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
MROTU	GO:0016779	nucleotidyltransferase activity	Gains
MROTU	GO:0070001	aspartic-type peptidase activity	Gains
MROTU	GO:0004190	aspartic-type endopeptidase activity	Gains
MROTU	GO:0140097	catalytic activity, acting on DNA	Gains
MROTU	GO:0099600	transmembrane receptor activity	Gains
MROTU	GO:0004175	endopeptidase activity	Gains
MROTU	GO:0038023	signaling receptor activity	Gains
MROTU	GO:0004872	receptor activity	Gains
MROTU	GO:0004888	transmembrane signaling receptor activity	Gains
MROTU	GO:0060089	molecular transducer activity	Gains
MROTU	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
MROTU	GO:0008233	peptidase activity	Gains
MROTU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
MROTU	GO:0008270	zinc ion binding	Gains
MROTU	GO:0004984	olfactory receptor activity	Gains
MROTU	GO:0046914	transition metal ion binding	Gains
MROTU	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
MROTU	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
MROTU	GO:0004871	signal transducer activity	Gains
MROTU	GO:0004519	endonuclease activity	Gains
MROTU	GO:0004521	endoribonuclease activity	Gains
MROTU	GO:0004930	G-protein coupled receptor activity	Gains
MROTU	GO:0008174	mRNA methyltransferase activity	Gains
MROTU	GO:0005549	odorant binding	Gains
MROTU	GO:0003676	nucleic acid binding	Gains
MROTU	GO:0034062	5'-3' RNA polymerase activity	Gains
MROTU	GO:0097747	RNA polymerase activity	Gains
MROTU	GO:0042302	structural constituent of cuticle	Gains
MROTU	GO:0004620	phospholipase activity	Gains
MROTU	GO:0016411	acylglycerol O-acyltransferase activity	Gains
MROTU	GO:0004629	phospholipase C activity	Gains
MROTU	GO:0042562	hormone binding	Gains
MROTU	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
MROTU	GO:0015026	coreceptor activity	Gains
MROTU	GO:0030267	glyoxylate reductase (NADP) activity	Gains
MROTU	GO:0070976	TIR domain binding	Gains
MROTU	GO:0004528	phosphodiesterase I activity	Gains
MROTU	GO:0003923	GPI-anchor transamidase activity	Gains
MROTU	GO:0097493	structural molecule activity conferring elasticity	Gains
MROTU	GO:0003945	N-acetyllactosamine synthase activity	Gains
MROTU	GO:0072320	volume-sensitive chloride channel activity	Gains
MROTU	GO:0015151	alpha-glucoside transmembrane transporter activity	Gains
MROTU	GO:0042654	ecdysis-triggering hormone receptor activity	Gains
MROTU	GO:0004997	thyrotropin-releasing hormone receptor activity	Gains
MROTU	GO:0015204	urea transmembrane transporter activity	Gains
MROTU	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
MROTU	GO:0008428	ribonuclease inhibitor activity	Gains
MROTU	GO:0035237	corazonin receptor activity	Gains
MROTU	GO:0033867	Fas-activated serine/threonine kinase activity	Gains
MROTU	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Gains
MROTU	GO:0043855	cyclic nucleotide-gated ion channel activity	Gains
MROTU	GO:0015574	trehalose transmembrane transporter activity	Gains
MROTU	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Gains
MROTU	GO:0005222	intracellular cAMP activated cation channel activity	Gains
MROTU	GO:0005223	intracellular cGMP activated cation channel activity	Gains
MROTU	GO:0005225	volume-sensitive anion channel activity	Gains
MROTU	GO:0042947	glucoside transmembrane transporter activity	Gains
MROTU	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	Gains
MROTU	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Gains
MROTU	GO:0047964	glyoxylate reductase activity	Gains
MROTU	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	Gains
MROTU	GO:0008747	N-acetylneuraminate lyase activity	Gains
MROTU	GO:0048531	beta-1,3-galactosyltransferase activity	Gains
MROTU	GO:0035529	NADH pyrophosphatase activity	Gains
MROTU	GO:0008376	acetylgalactosaminyltransferase activity	Gains
MROTU	GO:0052745	inositol phosphate phosphatase activity	Gains
MROTU	GO:0140103	catalytic activity, acting on a glycoprotein	Gains
MROTU	GO:0004540	ribonuclease activity	Gains
MROTU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
MROTU	GO:0016298	lipase activity	Gains
MROTU	GO:0016740	transferase activity	Gains
MROTU	GO:0046872	metal ion binding	Gains
MROTU	GO:0016788	hydrolase activity, acting on ester bonds	Gains
MROTU	GO:0004518	nuclease activity	Gains
MROTU	GO:0043169	cation binding	Gains
MROTU	GO:0008061	chitin binding	Gains
MROTU	GO:0008188	neuropeptide receptor activity	Gains
MROTU	GO:0003990	acetylcholinesterase activity	Losses
MROTU	GO:0004104	cholinesterase activity	Losses
MROTU	GO:0015301	anion:anion antiporter activity	Losses
MROTU	GO:0070001	aspartic-type peptidase activity	Losses
MROTU	GO:0004190	aspartic-type endopeptidase activity	Losses
MROTU	GO:0005215	transporter activity	Losses
MROTU	GO:0008061	chitin binding	Losses
MROTU	GO:0022838	substrate-specific channel activity	Losses
MROTU	GO:0008081	phosphoric diester hydrolase activity	Losses
MROTU	GO:0022803	passive transmembrane transporter activity	Losses
MROTU	GO:0015267	channel activity	Losses
MROTU	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Losses
MROTU	GO:0005200	structural constituent of cytoskeleton	Losses
MROTU	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
MROTU	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
MROTU	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
MROTU	GO:0003964	RNA-directed DNA polymerase activity	Losses
MROTU	GO:0005216	ion channel activity	Losses
MROTU	GO:0015075	ion transmembrane transporter activity	Losses
MROTU	GO:0003954	NADH dehydrogenase activity	Losses
MROTU	GO:0004568	chitinase activity	Losses
MROTU	GO:0016805	dipeptidase activity	Losses
MROTU	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Losses
MROTU	GO:0031409	pigment binding	Losses
MROTU	GO:0004620	phospholipase activity	Losses
MROTU	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
MROTU	GO:0005261	cation channel activity	Losses
MROTU	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
MROTU	GO:0022891	substrate-specific transmembrane transporter activity	Losses
MROTU	GO:0019239	deaminase activity	Losses
MROTU	GO:0005214	structural constituent of chitin-based cuticle	Losses
MROTU	GO:0008239	dipeptidyl-peptidase activity	Losses
MROTU	GO:0004000	adenosine deaminase activity	Losses
MROTU	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
MROTU	GO:0034061	DNA polymerase activity	Losses
MROTU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
MROTU	GO:0022857	transmembrane transporter activity	Losses
MROTU	GO:0022890	inorganic cation transmembrane transporter activity	Losses
MROTU	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Losses
MROTU	GO:0008079	translation termination factor activity	Losses
MROTU	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
MROTU	GO:0004935	adrenergic receptor activity	Losses
MROTU	GO:0003747	translation release factor activity	Losses
MROTU	GO:0005245	voltage-gated calcium channel activity	Losses
MROTU	GO:0008233	peptidase activity	Losses
MROTU	GO:0022892	substrate-specific transporter activity	Losses
MROTU	GO:0046790	virion binding	Losses
MROTU	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Losses
MROTU	GO:0005545	1-phosphatidylinositol binding	Losses
MROTU	GO:0016534	cyclin-dependent protein kinase 5 activator activity	Losses
MROTU	GO:0019153	protein-disulfide reductase (glutathione) activity	Losses
MROTU	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
MROTU	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
MROTU	GO:0003919	FMN adenylyltransferase activity	Losses
MROTU	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
MROTU	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
MROTU	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Losses
MROTU	GO:0000700	mismatch base pair DNA N-glycosylase activity	Losses
MROTU	GO:0032542	sulfiredoxin activity	Losses
MROTU	GO:0004097	catechol oxidase activity	Losses
MROTU	GO:0004060	arylamine N-acetyltransferase activity	Losses
MROTU	GO:0004055	argininosuccinate synthase activity	Losses
MROTU	GO:0004056	argininosuccinate lyase activity	Losses
MROTU	GO:0004059	aralkylamine N-acetyltransferase activity	Losses
MROTU	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Losses
MROTU	GO:0015250	water channel activity	Losses
MROTU	GO:0015217	ADP transmembrane transporter activity	Losses
MROTU	GO:0005372	water transmembrane transporter activity	Losses
MROTU	GO:0005347	ATP transmembrane transporter activity	Losses
MROTU	GO:0005471	ATP:ADP antiporter activity	Losses
MROTU	GO:0018834	dichloromethane dehalogenase activity	Losses
MROTU	GO:0035755	cardiolipin hydrolase activity	Losses
MROTU	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
MROTU	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
MROTU	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Losses
MROTU	GO:0052870	tocopherol omega-hydroxylase activity	Losses
MROTU	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
MROTU	GO:0008255	ecdysis-triggering hormone activity	Losses
MROTU	GO:0004321	fatty-acyl-CoA synthase activity	Losses
MROTU	GO:0004324	ferredoxin-NADP+ reductase activity	Losses
MROTU	GO:0042979	ornithine decarboxylase regulator activity	Losses
MROTU	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Losses
MROTU	GO:0010461	light-activated ion channel activity	Losses
MROTU	GO:0008768	UDP-sugar diphosphatase activity	Losses
MROTU	GO:0002046	opsin binding	Losses
MROTU	GO:0036263	L-DOPA monooxygenase activity	Losses
MROTU	GO:0036264	dopamine monooxygenase activity	Losses
MROTU	GO:0008873	gluconate 2-dehydrogenase activity	Losses
MROTU	GO:0008875	gluconate dehydrogenase activity	Losses
MROTU	GO:0004126	cytidine deaminase activity	Losses
MROTU	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
MROTU	GO:1902936	phosphatidylinositol bisphosphate binding	Losses
MROTU	GO:0005102	receptor binding	Losses
MROTU	GO:0016298	lipase activity	Losses
MROTU	GO:0005267	potassium channel activity	Losses
MROTU	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
MROTU	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
MROTU	GO:0070001	aspartic-type peptidase activity	Extinctions
MROTU	GO:0004190	aspartic-type endopeptidase activity	Extinctions
MROTU	GO:0003954	NADH dehydrogenase activity	Extinctions
MROTU	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
MROTU	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
MROTU	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Extinctions
MROTU	GO:0034061	DNA polymerase activity	Extinctions
MROTU	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Extinctions
MROTU	GO:0005200	structural constituent of cytoskeleton	Extinctions
MROTU	GO:1902936	phosphatidylinositol bisphosphate binding	Extinctions
MROTU	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
MROTU	GO:0019239	deaminase activity	Extinctions
MROTU	GO:0030145	manganese ion binding	Extinctions
MROTU	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
MROTU	GO:0016779	nucleotidyltransferase activity	Extinctions
MROTU	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
MROTU	GO:0005545	1-phosphatidylinositol binding	Extinctions
MROTU	GO:0016534	cyclin-dependent protein kinase 5 activator activity	Extinctions
MROTU	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
MROTU	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
MROTU	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Extinctions
MROTU	GO:0032542	sulfiredoxin activity	Extinctions
MROTU	GO:0004060	arylamine N-acetyltransferase activity	Extinctions
MROTU	GO:0004055	argininosuccinate synthase activity	Extinctions
MROTU	GO:0004056	argininosuccinate lyase activity	Extinctions
MROTU	GO:0004059	aralkylamine N-acetyltransferase activity	Extinctions
MROTU	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Extinctions
MROTU	GO:0018834	dichloromethane dehalogenase activity	Extinctions
MROTU	GO:0035755	cardiolipin hydrolase activity	Extinctions
MROTU	GO:0008255	ecdysis-triggering hormone activity	Extinctions
MROTU	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
MROTU	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
MROTU	GO:0008768	UDP-sugar diphosphatase activity	Extinctions
MROTU	GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
MROTU	GO:0008875	gluconate dehydrogenase activity	Extinctions
MROTU	GO:0004126	cytidine deaminase activity	Extinctions
MROTU	GO:0005112	Notch binding	Extinctions
MROTU	GO:0033613	activating transcription factor binding	Extinctions
MROTU	GO:0004175	endopeptidase activity	Extinctions
MROTU	GO:0008233	peptidase activity	Extinctions
MROTU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
MROTU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
MROTU	GO:0004000	adenosine deaminase activity	Extinctions
CAQUI	GO:0004930	G-protein coupled receptor activity	Gains
CAQUI	GO:0004888	transmembrane signaling receptor activity	Gains
CAQUI	GO:0099600	transmembrane receptor activity	Gains
CAQUI	GO:0038023	signaling receptor activity	Gains
CAQUI	GO:0008528	G-protein coupled peptide receptor activity	Gains
CAQUI	GO:0001653	peptide receptor activity	Gains
CAQUI	GO:0008188	neuropeptide receptor activity	Gains
CAQUI	GO:0005000	vasopressin receptor activity	Gains
CAQUI	GO:0060089	molecular transducer activity	Gains
CAQUI	GO:0004872	receptor activity	Gains
CAQUI	GO:0016500	protein-hormone receptor activity	Gains
CAQUI	GO:0004497	monooxygenase activity	Gains
CAQUI	GO:0004871	signal transducer activity	Gains
CAQUI	GO:0030594	neurotransmitter receptor activity	Gains
CAQUI	GO:0030332	cyclin binding	Gains
CAQUI	GO:0005230	extracellular ligand-gated ion channel activity	Gains
CAQUI	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
CAQUI	GO:0008066	glutamate receptor activity	Gains
CAQUI	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	Gains
CAQUI	GO:0004890	GABA-A receptor activity	Gains
CAQUI	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
CAQUI	GO:0005534	galactose binding	Gains
CAQUI	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
CAQUI	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
CAQUI	GO:0004971	AMPA glutamate receptor activity	Gains
CAQUI	GO:0097003	adipokinetic hormone receptor activity	Gains
CAQUI	GO:0097004	adipokinetic hormone binding	Gains
CAQUI	GO:0000049	tRNA binding	Gains
CAQUI	GO:0016877	ligase activity, forming carbon-sulfur bonds	Gains
CAQUI	GO:0070330	aromatase activity	Gains
CAQUI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
CAQUI	GO:0016917	GABA receptor activity	Gains
CAQUI	GO:0022824	transmitter-gated ion channel activity	Gains
CAQUI	GO:0022835	transmitter-gated channel activity	Gains
CAQUI	GO:0005507	copper ion binding	Gains
CAQUI	GO:0004970	ionotropic glutamate receptor activity	Gains
CAQUI	GO:0004190	aspartic-type endopeptidase activity	Gains
CAQUI	GO:0070001	aspartic-type peptidase activity	Gains
CAQUI	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
CAQUI	GO:0005506	iron ion binding	Gains
CAQUI	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
CAQUI	GO:0008484	sulfuric ester hydrolase activity	Gains
CAQUI	GO:0015645	fatty acid ligase activity	Gains
CAQUI	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
CAQUI	GO:0046915	transition metal ion transmembrane transporter activity	Gains
CAQUI	GO:0015276	ligand-gated ion channel activity	Gains
CAQUI	GO:0022834	ligand-gated channel activity	Gains
CAQUI	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
CAQUI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
CAQUI	GO:0004161	dimethylallyltranstransferase activity	Gains
CAQUI	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
CAQUI	GO:0017046	peptide hormone binding	Gains
CAQUI	GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
CAQUI	GO:0016413	O-acetyltransferase activity	Gains
CAQUI	GO:0004818	glutamate-tRNA ligase activity	Gains
CAQUI	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
CAQUI	GO:0097642	calcitonin family receptor activity	Gains
CAQUI	GO:0008036	diuretic hormone receptor activity	Gains
CAQUI	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
CAQUI	GO:0004950	chemokine receptor activity	Gains
CAQUI	GO:0004972	NMDA glutamate receptor activity	Gains
CAQUI	GO:0004948	calcitonin receptor activity	Gains
CAQUI	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Gains
CAQUI	GO:0008140	cAMP response element binding protein binding	Gains
CAQUI	GO:0003964	RNA-directed DNA polymerase activity	Losses
CAQUI	GO:0140097	catalytic activity, acting on DNA	Losses
CAQUI	GO:0016779	nucleotidyltransferase activity	Losses
CAQUI	GO:0034061	DNA polymerase activity	Losses
CAQUI	GO:0004190	aspartic-type endopeptidase activity	Losses
CAQUI	GO:0070001	aspartic-type peptidase activity	Losses
CAQUI	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
CAQUI	GO:0009881	photoreceptor activity	Losses
CAQUI	GO:0005214	structural constituent of chitin-based cuticle	Losses
CAQUI	GO:0003677	DNA binding	Losses
CAQUI	GO:0030247	polysaccharide binding	Losses
CAQUI	GO:0001871	pattern binding	Losses
CAQUI	GO:0060089	molecular transducer activity	Losses
CAQUI	GO:0004872	receptor activity	Losses
CAQUI	GO:0004871	signal transducer activity	Losses
CAQUI	GO:0043169	cation binding	Losses
CAQUI	GO:0046872	metal ion binding	Losses
CAQUI	GO:0008889	glycerophosphodiester phosphodiesterase activity	Losses
CAQUI	GO:0003700	DNA binding transcription factor activity	Losses
CAQUI	GO:0038023	signaling receptor activity	Losses
CAQUI	GO:0030246	carbohydrate binding	Losses
CAQUI	GO:0003676	nucleic acid binding	Losses
CAQUI	GO:0004129	cytochrome-c oxidase activity	Losses
CAQUI	GO:0015002	heme-copper terminal oxidase activity	Losses
CAQUI	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
CAQUI	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
CAQUI	GO:0004984	olfactory receptor activity	Losses
CAQUI	GO:0005044	scavenger receptor activity	Losses
CAQUI	GO:0140110	transcription regulator activity	Losses
CAQUI	GO:0042834	peptidoglycan binding	Losses
CAQUI	GO:0001530	lipopolysaccharide binding	Losses
CAQUI	GO:0042302	structural constituent of cuticle	Losses
CAQUI	GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
CAQUI	GO:0008270	zinc ion binding	Losses
CAQUI	GO:0046914	transition metal ion binding	Losses
CAQUI	GO:0003989	acetyl-CoA carboxylase activity	Losses
CAQUI	GO:0004519	endonuclease activity	Losses
CAQUI	GO:0038024	cargo receptor activity	Losses
CAQUI	GO:0005549	odorant binding	Losses
CAQUI	GO:0099600	transmembrane receptor activity	Losses
CAQUI	GO:0004518	nuclease activity	Losses
CAQUI	GO:0004888	transmembrane signaling receptor activity	Losses
CAQUI	GO:0061134	peptidase regulator activity	Losses
CAQUI	GO:0008241	peptidyl-dipeptidase activity	Losses
CAQUI	GO:0008527	taste receptor activity	Losses
CAQUI	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
CAQUI	GO:0009882	blue light photoreceptor activity	Losses
CAQUI	GO:0030546	receptor activator activity	Losses
CAQUI	GO:0003913	DNA photolyase activity	Losses
CAQUI	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
CAQUI	GO:0001872	(1->3)-beta-D-glucan binding	Losses
CAQUI	GO:0008020	G-protein coupled photoreceptor activity	Losses
CAQUI	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
CAQUI	GO:0009378	four-way junction helicase activity	Losses
CAQUI	GO:0004866	endopeptidase inhibitor activity	Losses
CAQUI	GO:0003990	acetylcholinesterase activity	Losses
CAQUI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
CAQUI	GO:0004089	carbonate dehydratase activity	Losses
CAQUI	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
CAQUI	GO:0003682	chromatin binding	Losses
CAQUI	GO:0046982	protein heterodimerization activity	Losses
CAQUI	GO:0005179	hormone activity	Losses
CAQUI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
CAQUI	GO:0030414	peptidase inhibitor activity	Losses
CAQUI	GO:0030545	receptor regulator activity	Losses
CAQUI	GO:0061135	endopeptidase regulator activity	Losses
CAQUI	GO:0005319	lipid transporter activity	Losses
CAQUI	GO:0004857	enzyme inhibitor activity	Losses
CAQUI	GO:0004104	cholinesterase activity	Losses
CAQUI	GO:0097157	pre-mRNA intronic binding	Losses
CAQUI	GO:0030882	lipid antigen binding	Losses
CAQUI	GO:0035613	RNA stem-loop binding	Losses
CAQUI	GO:0003978	UDP-glucose 4-epimerase activity	Losses
CAQUI	GO:0005501	retinoid binding	Losses
CAQUI	GO:0070891	lipoteichoic acid binding	Losses
CAQUI	GO:0043015	gamma-tubulin binding	Losses
CAQUI	GO:0038187	pattern recognition receptor activity	Losses
CAQUI	GO:0008329	signaling pattern recognition receptor activity	Losses
CAQUI	GO:0004342	glucosamine-6-phosphate deaminase activity	Losses
CAQUI	GO:0008190	eukaryotic initiation factor 4E binding	Losses
CAQUI	GO:0016421	CoA carboxylase activity	Losses
CAQUI	GO:0005488	binding	Losses
CAQUI	GO:0016854	racemase and epimerase activity	Losses
CAQUI	GO:0031369	translation initiation factor binding	Losses
CAQUI	GO:0015631	tubulin binding	Losses
CAQUI	GO:0030247	polysaccharide binding	Extinctions
CAQUI	GO:0001871	pattern binding	Extinctions
CAQUI	GO:0009881	photoreceptor activity	Extinctions
CAQUI	GO:0003676	nucleic acid binding	Extinctions
CAQUI	GO:0003677	DNA binding	Extinctions
CAQUI	GO:0042834	peptidoglycan binding	Extinctions
CAQUI	GO:0001530	lipopolysaccharide binding	Extinctions
CAQUI	GO:0003700	DNA binding transcription factor activity	Extinctions
CAQUI	GO:0140097	catalytic activity, acting on DNA	Extinctions
CAQUI	GO:0008527	taste receptor activity	Extinctions
CAQUI	GO:0016779	nucleotidyltransferase activity	Extinctions
CAQUI	GO:0140110	transcription regulator activity	Extinctions
CAQUI	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
CAQUI	GO:0030546	receptor activator activity	Extinctions
CAQUI	GO:0003913	DNA photolyase activity	Extinctions
CAQUI	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
CAQUI	GO:0001872	(1->3)-beta-D-glucan binding	Extinctions
CAQUI	GO:0008020	G-protein coupled photoreceptor activity	Extinctions
CAQUI	GO:0009378	four-way junction helicase activity	Extinctions
CAQUI	GO:0061134	peptidase regulator activity	Extinctions
CAQUI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
CAQUI	GO:0030545	receptor regulator activity	Extinctions
CAQUI	GO:0005179	hormone activity	Extinctions
CAQUI	GO:0016885	ligase activity, forming carbon-carbon bonds	Extinctions
CAQUI	GO:0046982	protein heterodimerization activity	Extinctions
CAQUI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
CAQUI	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
CAQUI	GO:0030246	carbohydrate binding	Extinctions
CAQUI	GO:0015631	tubulin binding	Extinctions
CAQUI	GO:0003682	chromatin binding	Extinctions
CAQUI	GO:0097157	pre-mRNA intronic binding	Extinctions
CAQUI	GO:0008889	glycerophosphodiester phosphodiesterase activity	Extinctions
CAQUI	GO:0030882	lipid antigen binding	Extinctions
CAQUI	GO:0035613	RNA stem-loop binding	Extinctions
CAQUI	GO:0005501	retinoid binding	Extinctions
CAQUI	GO:0070891	lipoteichoic acid binding	Extinctions
CAQUI	GO:0043015	gamma-tubulin binding	Extinctions
CAQUI	GO:0038187	pattern recognition receptor activity	Extinctions
CAQUI	GO:0008329	signaling pattern recognition receptor activity	Extinctions
CAQUI	GO:0008190	eukaryotic initiation factor 4E binding	Extinctions
CAQUI	GO:0004871	signal transducer activity	Extinctions
CAQUI	GO:0004866	endopeptidase inhibitor activity	Extinctions
CAQUI	GO:0004857	enzyme inhibitor activity	Extinctions
CAQUI	GO:0003989	acetyl-CoA carboxylase activity	Extinctions
CAQUI	GO:0031369	translation initiation factor binding	Extinctions
CAQUI	GO:0005044	scavenger receptor activity	Extinctions
CAQUI	GO:0030414	peptidase inhibitor activity	Extinctions
CAQUI	GO:0008066	glutamate receptor activity	Extinctions
CAQUI	GO:0061135	endopeptidase regulator activity	Extinctions
CAQUI	GO:0004129	cytochrome-c oxidase activity	Extinctions
CAQUI	GO:0015002	heme-copper terminal oxidase activity	Extinctions
CAQUI	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
CAQUI	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
CAQUI	GO:0004143	diacylglycerol kinase activity	Extinctions
CAQUI	GO:0004529	exodeoxyribonuclease activity	Extinctions
CAQUI	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
CAQUI	GO:0004519	endonuclease activity	Extinctions
CAQUI	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	Extinctions
CAQUI	GO:0030296	protein tyrosine kinase activator activity	Extinctions
CAQUI	GO:0003823	antigen binding	Extinctions
CAQUI	GO:0004736	pyruvate carboxylase activity	Extinctions
CAQUI	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Extinctions
CAQUI	GO:0004813	alanine-tRNA ligase activity	Extinctions
CAQUI	GO:0001671	ATPase activator activity	Extinctions
CAQUI	GO:0009008	DNA-methyltransferase activity	Extinctions
HE11	GO:0003964	RNA-directed DNA polymerase activity	Gains
HE11	GO:0003676	nucleic acid binding	Gains
HE11	GO:0034061	DNA polymerase activity	Gains
HE11	GO:0140097	catalytic activity, acting on DNA	Gains
HE11	GO:0016779	nucleotidyltransferase activity	Gains
HE11	GO:0004519	endonuclease activity	Gains
HE11	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
HE11	GO:0004629	phospholipase C activity	Gains
HE11	GO:0097159	organic cyclic compound binding	Gains
HE11	GO:0004518	nuclease activity	Gains
HE11	GO:1901363	heterocyclic compound binding	Gains
HE11	GO:0030983	mismatched DNA binding	Gains
HE11	GO:0042393	histone binding	Gains
HE11	GO:0003723	RNA binding	Gains
HE11	GO:0004619	phosphoglycerate mutase activity	Gains
HE11	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HE11	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HE11	GO:0051015	actin filament binding	Gains
HE11	GO:0003682	chromatin binding	Gains
HE11	GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
HE11	GO:0033981	D-dopachrome decarboxylase activity	Gains
HE11	GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
HE11	GO:0033932	1,3-alpha-L-fucosidase activity	Gains
HE11	GO:0048495	Roundabout binding	Gains
HE11	GO:0070976	TIR domain binding	Gains
HE11	GO:0004122	cystathionine beta-synthase activity	Gains
HE11	GO:0004133	glycogen debranching enzyme activity	Gains
HE11	GO:0004134	4-alpha-glucanotransferase activity	Gains
HE11	GO:0004135	amylo-alpha-1,6-glucosidase activity	Gains
HE11	GO:0008511	sodium:potassium:chloride symporter activity	Gains
HE11	GO:0016287	glycerone-phosphate O-acyltransferase activity	Gains
HE11	GO:0004802	transketolase activity	Gains
HE11	GO:0034416	bisphosphoglycerate phosphatase activity	Gains
HE11	GO:0009014	succinyl-diaminopimelate desuccinylase activity	Gains
HE11	GO:0017172	cysteine dioxygenase activity	Gains
HE11	GO:0015026	coreceptor activity	Gains
HE11	GO:0047485	protein N-terminus binding	Gains
HE11	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Gains
HE11	GO:0034701	tripeptidase activity	Gains
HE11	GO:0004099	chitin deacetylase activity	Gains
HE11	GO:0004082	bisphosphoglycerate mutase activity	Gains
HE11	GO:0004083	bisphosphoglycerate 2-phosphatase activity	Gains
HE11	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HE11	GO:0099600	transmembrane receptor activity	Gains
HE11	GO:0004984	olfactory receptor activity	Gains
HE11	GO:0004521	endoribonuclease activity	Gains
HE11	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
HE11	GO:0043546	molybdopterin cofactor binding	Losses
HE11	GO:0051371	muscle alpha-actinin binding	Losses
HE11	GO:0008484	sulfuric ester hydrolase activity	Losses
HE11	GO:0042834	peptidoglycan binding	Losses
HE11	GO:0016878	acid-thiol ligase activity	Losses
HE11	GO:0017171	serine hydrolase activity	Losses
HE11	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
HE11	GO:0042805	actinin binding	Losses
HE11	GO:0051393	alpha-actinin binding	Losses
HE11	GO:0009378	four-way junction helicase activity	Losses
HE11	GO:0046592	polyamine oxidase activity	Losses
HE11	GO:0008289	lipid binding	Losses
HE11	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Losses
HE11	GO:0008236	serine-type peptidase activity	Losses
HE11	GO:0004180	carboxypeptidase activity	Losses
HE11	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
HE11	GO:0008329	signaling pattern recognition receptor activity	Losses
HE11	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
HE11	GO:0038187	pattern recognition receptor activity	Losses
HE11	GO:0001530	lipopolysaccharide binding	Losses
HE11	GO:0048038	quinone binding	Losses
HE11	GO:0030151	molybdenum ion binding	Losses
HE11	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
HE11	GO:0016630	protochlorophyllide reductase activity	Losses
HE11	GO:0061783	peptidoglycan muralytic activity	Losses
HE11	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
HE11	GO:0005539	glycosaminoglycan binding	Losses
HE11	GO:0016229	steroid dehydrogenase activity	Losses
HE11	GO:0019842	vitamin binding	Losses
HE11	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
HE11	GO:0008519	ammonium transmembrane transporter activity	Losses
HE11	GO:0008238	exopeptidase activity	Losses
HE11	GO:0048037	cofactor binding	Losses
HE11	GO:0099589	serotonin receptor activity	Losses
HE11	GO:0004813	alanine-tRNA ligase activity	Losses
HE11	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Losses
HE11	GO:0004993	G-protein coupled serotonin receptor activity	Losses
HE11	GO:0030145	manganese ion binding	Losses
HE11	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
HE11	GO:0008484	sulfuric ester hydrolase activity	Extinctions
HE11	GO:0042834	peptidoglycan binding	Extinctions
HE11	GO:0009378	four-way junction helicase activity	Extinctions
HE11	GO:0008329	signaling pattern recognition receptor activity	Extinctions
HE11	GO:0038187	pattern recognition receptor activity	Extinctions
HE11	GO:0001530	lipopolysaccharide binding	Extinctions
HE11	GO:0016630	protochlorophyllide reductase activity	Extinctions
HE11	GO:0008289	lipid binding	Extinctions
HE11	GO:0030145	manganese ion binding	Extinctions
HE11	GO:0019842	vitamin binding	Extinctions
HE11	GO:0004813	alanine-tRNA ligase activity	Extinctions
HE11	GO:0016805	dipeptidase activity	Extinctions
HE11	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
HE11	GO:0008482	sulfite oxidase activity	Extinctions
HE11	GO:0016019	peptidoglycan receptor activity	Extinctions
HE11	GO:0015485	cholesterol binding	Extinctions
HE11	GO:0016936	galactoside binding	Extinctions
HE11	GO:0015145	monosaccharide transmembrane transporter activity	Extinctions
HE11	GO:0015149	hexose transmembrane transporter activity	Extinctions
HE11	GO:0004423	iduronate-2-sulfatase activity	Extinctions
HE11	GO:0004411	homogentisate 1,2-dioxygenase activity	Extinctions
HE11	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity	Extinctions
HE11	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
HE11	GO:0015248	sterol transporter activity	Extinctions
HE11	GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	Extinctions
HE11	GO:0008743	L-threonine 3-dehydrogenase activity	Extinctions
HE11	GO:0008881	glutamate racemase activity	Extinctions
HE11	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
HE11	GO:0016160	amylase activity	Extinctions
HE11	GO:0032500	muramyl dipeptide binding	Extinctions
HE11	GO:0004769	steroid delta-isomerase activity	Extinctions
HE11	GO:0015578	mannose transmembrane transporter activity	Extinctions
HE11	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Extinctions
HE11	GO:0000254	C-4 methylsterol oxidase activity	Extinctions
HE11	GO:0004844	uracil DNA N-glycosylase activity	Extinctions
HE11	GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	Extinctions
HE11	GO:0005537	mannose binding	Extinctions
HE11	GO:0004556	alpha-amylase activity	Extinctions
HE11	GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
HE11	GO:0001875	lipopolysaccharide receptor activity	Extinctions
HE11	GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Extinctions
HE11	GO:0050080	malonyl-CoA decarboxylase activity	Extinctions
HE11	GO:0035237	corazonin receptor activity	Extinctions
HE11	GO:0017127	cholesterol transporter activity	Extinctions
HE11	GO:0005031	tumor necrosis factor-activated receptor activity	Extinctions
HE11	GO:0005035	death receptor activity	Extinctions
HE11	GO:0004092	carnitine O-acetyltransferase activity	Extinctions
HE11	GO:0004053	arginase activity	Extinctions
HE11	GO:0070547	L-tyrosine aminotransferase activity	Extinctions
HE11	GO:0097506	deaminated base DNA N-glycosylase activity	Extinctions
HE11	GO:0005539	glycosaminoglycan binding	Extinctions
HLABO	GO:0003964	RNA-directed DNA polymerase activity	Gains
HLABO	GO:0034061	DNA polymerase activity	Gains
HLABO	GO:0016779	nucleotidyltransferase activity	Gains
HLABO	GO:0140097	catalytic activity, acting on DNA	Gains
HLABO	GO:0003676	nucleic acid binding	Gains
HLABO	GO:0004190	aspartic-type endopeptidase activity	Gains
HLABO	GO:0070001	aspartic-type peptidase activity	Gains
HLABO	GO:0004803	transposase activity	Gains
HLABO	GO:0004175	endopeptidase activity	Gains
HLABO	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HLABO	GO:0004984	olfactory receptor activity	Gains
HLABO	GO:0005549	odorant binding	Gains
HLABO	GO:0003677	DNA binding	Gains
HLABO	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HLABO	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HLABO	GO:0008233	peptidase activity	Gains
HLABO	GO:0003723	RNA binding	Gains
HLABO	GO:0008270	zinc ion binding	Gains
HLABO	GO:1901363	heterocyclic compound binding	Gains
HLABO	GO:0097159	organic cyclic compound binding	Gains
HLABO	GO:0046914	transition metal ion binding	Gains
HLABO	GO:0004518	nuclease activity	Gains
HLABO	GO:0038023	signaling receptor activity	Gains
HLABO	GO:0004888	transmembrane signaling receptor activity	Gains
HLABO	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
HLABO	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	Gains
HLABO	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Gains
HLABO	GO:0004872	receptor activity	Gains
HLABO	GO:0004222	metalloendopeptidase activity	Gains
HLABO	GO:0060089	molecular transducer activity	Gains
HLABO	GO:0004519	endonuclease activity	Gains
HLABO	GO:0099600	transmembrane receptor activity	Gains
HLABO	GO:0004540	ribonuclease activity	Gains
HLABO	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
HLABO	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
HLABO	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
HLABO	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
HLABO	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
HLABO	GO:0008237	metallopeptidase activity	Gains
HLABO	GO:0042834	peptidoglycan binding	Gains
HLABO	GO:0004521	endoribonuclease activity	Gains
HLABO	GO:0034062	5'-3' RNA polymerase activity	Gains
HLABO	GO:0097747	RNA polymerase activity	Gains
HLABO	GO:0008527	taste receptor activity	Gains
HLABO	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HLABO	GO:0005488	binding	Gains
HLABO	GO:0004871	signal transducer activity	Gains
HLABO	GO:0050660	flavin adenine dinucleotide binding	Gains
HLABO	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HLABO	GO:0005121	Toll binding	Gains
HLABO	GO:0004364	glutathione transferase activity	Gains
HLABO	GO:0030247	polysaccharide binding	Gains
HLABO	GO:0001871	pattern binding	Gains
HLABO	GO:1990939	ATP-dependent microtubule motor activity	Gains
HLABO	GO:0042943	D-amino acid transmembrane transporter activity	Gains
HLABO	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
HLABO	GO:0005125	cytokine activity	Gains
HLABO	GO:0004398	histidine decarboxylase activity	Gains
HLABO	GO:0004304	estrone sulfotransferase activity	Gains
HLABO	GO:0004499	N,N-dimethylaniline monooxygenase activity	Gains
HLABO	GO:0070818	protoporphyrinogen oxidase activity	Gains
HLABO	GO:0034584	piRNA binding	Gains
HLABO	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
HLABO	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
HLABO	GO:0046875	ephrin receptor binding	Gains
HLABO	GO:0001222	transcription corepressor binding	Gains
HLABO	GO:0001226	RNA polymerase II transcription corepressor binding	Gains
HLABO	GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	Gains
HLABO	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Gains
HLABO	GO:0016019	peptidoglycan receptor activity	Gains
HLABO	GO:0030544	Hsp70 protein binding	Gains
HLABO	GO:0001875	lipopolysaccharide receptor activity	Gains
HLABO	GO:0019811	cocaine binding	Gains
HLABO	GO:0008084	imaginal disc growth factor receptor binding	Gains
HLABO	GO:0016936	galactoside binding	Gains
HLABO	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
HLABO	GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
HLABO	GO:0004507	steroid 11-beta-monooxygenase activity	Gains
HLABO	GO:0032500	muramyl dipeptide binding	Gains
HLABO	GO:0008940	nitrate reductase activity	Gains
HLABO	GO:0015222	serotonin transmembrane transporter activity	Gains
HLABO	GO:0045127	N-acetylglucosamine kinase activity	Gains
HLABO	GO:0016499	orexin receptor activity	Gains
HLABO	GO:0018833	DDT-dehydrochlorinase activity	Gains
HLABO	GO:0004092	carnitine O-acetyltransferase activity	Gains
HLABO	GO:0004062	aryl sulfotransferase activity	Gains
HLABO	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Gains
HLABO	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
HLABO	GO:0032093	SAM domain binding	Gains
HLABO	GO:0004027	alcohol sulfotransferase activity	Gains
HLABO	GO:0005329	dopamine transmembrane transporter activity	Gains
HLABO	GO:0070410	co-SMAD binding	Gains
HLABO	GO:0046332	SMAD binding	Gains
HLABO	GO:0009703	nitrate reductase (NADH) activity	Gains
HLABO	GO:0071885	N-terminal protein N-methyltransferase activity	Gains
HLABO	GO:0042302	structural constituent of cuticle	Gains
HLABO	GO:0008061	chitin binding	Gains
HLABO	GO:0005539	glycosaminoglycan binding	Gains
HLABO	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HLABO	GO:0140098	catalytic activity, acting on RNA	Gains
HLABO	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	Losses
HLABO	GO:0035250	UDP-galactosyltransferase activity	Losses
HLABO	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
HLABO	GO:0019182	histamine-gated chloride channel activity	Losses
HLABO	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Losses
HLABO	GO:0005094	Rho GDP-dissociation inhibitor activity	Losses
HLABO	GO:0047886	farnesol dehydrogenase activity	Losses
HLABO	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
HLABO	GO:0004019	adenylosuccinate synthase activity	Losses
HLABO	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
HLABO	GO:0008378	galactosyltransferase activity	Losses
HLABO	GO:0005198	structural molecule activity	Losses
HLABO	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Losses
HLABO	GO:0097472	cyclin-dependent protein kinase activity	Losses
HLABO	GO:0004003	ATP-dependent DNA helicase activity	Losses
HLABO	GO:0003735	structural constituent of ribosome	Losses
HLABO	GO:0004857	enzyme inhibitor activity	Losses
HLABO	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Losses
HLABO	GO:0050824	water binding	Losses
HLABO	GO:0050825	ice binding	Losses
HLABO	GO:0050591	quinine 3-monooxygenase activity	Losses
HLABO	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Losses
HLABO	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
HLABO	GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
HLABO	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
HLABO	GO:0016531	copper chaperone activity	Losses
HLABO	GO:0042162	telomeric DNA binding	Losses
HLABO	GO:0099095	ligand-gated anion channel activity	Losses
HLABO	GO:0004753	saccharopine dehydrogenase activity	Losses
HLABO	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
HLABO	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Losses
HLABO	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Losses
HLABO	GO:0043138	3'-5' DNA helicase activity	Losses
HLABO	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
HLABO	GO:0031386	protein tag	Losses
HLABO	GO:0004054	arginine kinase activity	Losses
HLABO	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
HLABO	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
HLABO	GO:0016530	metallochaperone activity	Losses
HLABO	GO:0019202	amino acid kinase activity	Losses
HLABO	GO:0051287	NAD binding	Losses
HLABO	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	Extinctions
HLABO	GO:0035250	UDP-galactosyltransferase activity	Extinctions
HLABO	GO:0008378	galactosyltransferase activity	Extinctions
HLABO	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
HLABO	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Extinctions
HLABO	GO:0005094	Rho GDP-dissociation inhibitor activity	Extinctions
HLABO	GO:0004019	adenylosuccinate synthase activity	Extinctions
HLABO	GO:0004003	ATP-dependent DNA helicase activity	Extinctions
HLABO	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Extinctions
HLABO	GO:0050824	water binding	Extinctions
HLABO	GO:0050825	ice binding	Extinctions
HLABO	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Extinctions
HLABO	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Extinctions
HLABO	GO:0016531	copper chaperone activity	Extinctions
HLABO	GO:0042162	telomeric DNA binding	Extinctions
HLABO	GO:0004753	saccharopine dehydrogenase activity	Extinctions
HLABO	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Extinctions
HLABO	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Extinctions
HLABO	GO:0043138	3'-5' DNA helicase activity	Extinctions
HLABO	GO:0005198	structural molecule activity	Extinctions
HLABO	GO:0003735	structural constituent of ribosome	Extinctions
HLABO	GO:0016530	metallochaperone activity	Extinctions
HLABO	GO:0047915	ganglioside galactosyltransferase activity	Extinctions
HLABO	GO:0008036	diuretic hormone receptor activity	Extinctions
HLABO	GO:0042302	structural constituent of cuticle	Extinctions
HLABO	GO:0008094	DNA-dependent ATPase activity	Extinctions
HLABO	GO:0005092	GDP-dissociation inhibitor activity	Extinctions
LCUP2	GO:0003964	RNA-directed DNA polymerase activity	Gains
LCUP2	GO:0034061	DNA polymerase activity	Gains
LCUP2	GO:0008270	zinc ion binding	Gains
LCUP2	GO:0046914	transition metal ion binding	Gains
LCUP2	GO:0016779	nucleotidyltransferase activity	Gains
LCUP2	GO:0140097	catalytic activity, acting on DNA	Gains
LCUP2	GO:0003676	nucleic acid binding	Gains
LCUP2	GO:0004623	phospholipase A2 activity	Gains
LCUP2	GO:0035800	deubiquitinase activator activity	Gains
LCUP2	GO:0004632	phosphopantothenate--cysteine ligase activity	Gains
LCUP2	GO:0030246	carbohydrate binding	Gains
LCUP2	GO:0010181	FMN binding	Gains
LCUP2	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
LCUP2	GO:0043169	cation binding	Gains
LCUP2	GO:0046872	metal ion binding	Gains
LCUP2	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
LCUP2	GO:0005549	odorant binding	Gains
LCUP2	GO:0004930	G-protein coupled receptor activity	Gains
LCUP2	GO:0004497	monooxygenase activity	Gains
LCUP2	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
LCUP2	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
LCUP2	GO:0045289	luciferin monooxygenase activity	Gains
LCUP2	GO:0030976	thiamine pyrophosphate binding	Gains
LCUP2	GO:0008172	S-methyltransferase activity	Gains
LCUP2	GO:0008527	taste receptor activity	Gains
LCUP2	GO:0004984	olfactory receptor activity	Gains
LCUP2	GO:0099600	transmembrane receptor activity	Gains
LCUP2	GO:0042813	Wnt-activated receptor activity	Losses
LCUP2	GO:0046872	metal ion binding	Losses
LCUP2	GO:0043169	cation binding	Losses
LCUP2	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Losses
LCUP2	GO:0030165	PDZ domain binding	Losses
LCUP2	GO:0008270	zinc ion binding	Losses
LCUP2	GO:0043167	ion binding	Losses
LCUP2	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
LCUP2	GO:0019205	nucleobase-containing compound kinase activity	Losses
LCUP2	GO:0008013	beta-catenin binding	Losses
LCUP2	GO:0032934	sterol binding	Losses
LCUP2	GO:0005267	potassium channel activity	Losses
LCUP2	GO:0022843	voltage-gated cation channel activity	Losses
LCUP2	GO:0004190	aspartic-type endopeptidase activity	Losses
LCUP2	GO:0005244	voltage-gated ion channel activity	Losses
LCUP2	GO:0022832	voltage-gated channel activity	Losses
LCUP2	GO:0070001	aspartic-type peptidase activity	Losses
LCUP2	GO:0005249	voltage-gated potassium channel activity	Losses
LCUP2	GO:0043178	alcohol binding	Losses
LCUP2	GO:0001965	G-protein alpha-subunit binding	Losses
LCUP2	GO:0030234	enzyme regulator activity	Losses
LCUP2	GO:0016740	transferase activity	Losses
LCUP2	GO:0003924	GTPase activity	Losses
LCUP2	GO:0016301	kinase activity	Losses
LCUP2	GO:0015079	potassium ion transmembrane transporter activity	Losses
LCUP2	GO:0005496	steroid binding	Losses
LCUP2	GO:0019904	protein domain specific binding	Losses
LCUP2	GO:0017002	activin-activated receptor activity	Losses
LCUP2	GO:0048185	activin binding	Losses
LCUP2	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
LCUP2	GO:0008332	low voltage-gated calcium channel activity	Losses
LCUP2	GO:0035100	ecdysone binding	Losses
LCUP2	GO:0032093	SAM domain binding	Losses
LCUP2	GO:0032451	demethylase activity	Losses
LCUP2	GO:0032452	histone demethylase activity	Losses
LCUP2	GO:0008603	cAMP-dependent protein kinase regulator activity	Losses
LCUP2	GO:0004691	cAMP-dependent protein kinase activity	Losses
LCUP2	GO:0005092	GDP-dissociation inhibitor activity	Losses
LCUP2	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
LCUP2	GO:0017147	Wnt-protein binding	Losses
LCUP2	GO:0019201	nucleotide kinase activity	Losses
LCUP2	GO:0046914	transition metal ion binding	Losses
LCUP2	GO:0019206	nucleoside kinase activity	Losses
LCUP2	GO:0140097	catalytic activity, acting on DNA	Losses
LCUP2	GO:0061135	endopeptidase regulator activity	Losses
LCUP2	GO:0003746	translation elongation factor activity	Losses
LCUP2	GO:0015929	hexosaminidase activity	Losses
LCUP2	GO:0008239	dipeptidyl-peptidase activity	Losses
LCUP2	GO:0008812	choline dehydrogenase activity	Losses
LCUP2	GO:0016755	transferase activity, transferring amino-acyl groups	Losses
LCUP2	GO:0045296	cadherin binding	Losses
LCUP2	GO:0016615	malate dehydrogenase activity	Losses
LCUP2	GO:0004385	guanylate kinase activity	Losses
LCUP2	GO:0004303	estradiol 17-beta-dehydrogenase activity	Losses
LCUP2	GO:1901265	nucleoside phosphate binding	Losses
LCUP2	GO:0000166	nucleotide binding	Losses
LCUP2	GO:0019001	guanyl nucleotide binding	Losses
LCUP2	GO:0032561	guanyl ribonucleotide binding	Losses
LCUP2	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
LCUP2	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
LCUP2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Losses
LCUP2	GO:0016849	phosphorus-oxygen lyase activity	Losses
LCUP2	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
LCUP2	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
LCUP2	GO:0098599	palmitoyl hydrolase activity	Losses
LCUP2	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
LCUP2	GO:0005213	structural constituent of chorion	Losses
LCUP2	GO:0004161	dimethylallyltranstransferase activity	Losses
LCUP2	GO:0048027	mRNA 5'-UTR binding	Losses
LCUP2	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
LCUP2	GO:0019838	growth factor binding	Losses
LCUP2	GO:0032453	histone demethylase activity (H3-K4 specific)	Losses
LCUP2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Losses
LCUP2	GO:0061133	endopeptidase activator activity	Losses
LCUP2	GO:0004736	pyruvate carboxylase activity	Losses
LCUP2	GO:0010484	H3 histone acetyltransferase activity	Losses
LCUP2	GO:0035014	phosphatidylinositol 3-kinase regulator activity	Losses
LCUP2	GO:0050321	tau-protein kinase activity	Losses
LCUP2	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Losses
LCUP2	GO:0005024	transforming growth factor beta-activated receptor activity	Losses
LCUP2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	Losses
LCUP2	GO:0051864	histone demethylase activity (H3-K36 specific)	Losses
LCUP2	GO:0008474	palmitoyl-(protein) hydrolase activity	Losses
LCUP2	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
LCUP2	GO:0042393	histone binding	Losses
LCUP2	GO:0030695	GTPase regulator activity	Losses
LCUP2	GO:0004866	endopeptidase inhibitor activity	Losses
LCUP2	GO:0043178	alcohol binding	Extinctions
LCUP2	GO:0030165	PDZ domain binding	Extinctions
LCUP2	GO:0008603	cAMP-dependent protein kinase regulator activity	Extinctions
LCUP2	GO:0004691	cAMP-dependent protein kinase activity	Extinctions
LCUP2	GO:0008270	zinc ion binding	Extinctions
LCUP2	GO:0035100	ecdysone binding	Extinctions
LCUP2	GO:0140097	catalytic activity, acting on DNA	Extinctions
LCUP2	GO:0032934	sterol binding	Extinctions
LCUP2	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Extinctions
LCUP2	GO:0004003	ATP-dependent DNA helicase activity	Extinctions
LCUP2	GO:0042813	Wnt-activated receptor activity	Extinctions
LCUP2	GO:0003676	nucleic acid binding	Extinctions
LCUP2	GO:0003678	DNA helicase activity	Extinctions
LCUP2	GO:0005213	structural constituent of chorion	Extinctions
LCUP2	GO:0032453	histone demethylase activity (H3-K4 specific)	Extinctions
LCUP2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Extinctions
LCUP2	GO:0010484	H3 histone acetyltransferase activity	Extinctions
LCUP2	GO:0004692	cGMP-dependent protein kinase activity	Extinctions
LCUP2	GO:0005496	steroid binding	Extinctions
LCUP2	GO:0046914	transition metal ion binding	Extinctions
LCUP2	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
LCUP2	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
LCUP2	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
LCUP2	GO:0005267	potassium channel activity	Extinctions
LCUP2	GO:0016247	channel regulator activity	Extinctions
LCUP2	GO:0001965	G-protein alpha-subunit binding	Extinctions
LCUP2	GO:0015079	potassium ion transmembrane transporter activity	Extinctions
LCUP2	GO:0019904	protein domain specific binding	Extinctions
MSEXT	GO:0003964	RNA-directed DNA polymerase activity	Gains
MSEXT	GO:0034061	DNA polymerase activity	Gains
MSEXT	GO:0016779	nucleotidyltransferase activity	Gains
MSEXT	GO:0140097	catalytic activity, acting on DNA	Gains
MSEXT	GO:0070001	aspartic-type peptidase activity	Gains
MSEXT	GO:0004190	aspartic-type endopeptidase activity	Gains
MSEXT	GO:0008527	taste receptor activity	Gains
MSEXT	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
MSEXT	GO:0005549	odorant binding	Gains
MSEXT	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
MSEXT	GO:0046906	tetrapyrrole binding	Gains
MSEXT	GO:0016209	antioxidant activity	Gains
MSEXT	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
MSEXT	GO:0004601	peroxidase activity	Gains
MSEXT	GO:0004602	glutathione peroxidase activity	Gains
MSEXT	GO:0020037	heme binding	Gains
MSEXT	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
MSEXT	GO:0016740	transferase activity	Gains
MSEXT	GO:0015370	solute:sodium symporter activity	Gains
MSEXT	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
MSEXT	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
MSEXT	GO:0004819	glutamine-tRNA ligase activity	Gains
MSEXT	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
MSEXT	GO:0004040	amidase activity	Gains
MSEXT	GO:0030553	cGMP binding	Gains
MSEXT	GO:0003723	RNA binding	Gains
MSEXT	GO:0004866	endopeptidase inhibitor activity	Gains
MSEXT	GO:0060089	molecular transducer activity	Gains
MSEXT	GO:0004984	olfactory receptor activity	Gains
MSEXT	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
MSEXT	GO:0061135	endopeptidase regulator activity	Gains
MSEXT	GO:0016860	intramolecular oxidoreductase activity	Gains
MSEXT	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
MSEXT	GO:0004872	receptor activity	Gains
MSEXT	GO:0005506	iron ion binding	Gains
MSEXT	GO:0030414	peptidase inhibitor activity	Gains
MSEXT	GO:0003676	nucleic acid binding	Gains
MSEXT	GO:0099600	transmembrane receptor activity	Gains
MSEXT	GO:0097747	RNA polymerase activity	Gains
MSEXT	GO:0034062	5'-3' RNA polymerase activity	Gains
MSEXT	GO:0031409	pigment binding	Gains
MSEXT	GO:0005328	neurotransmitter:sodium symporter activity	Gains
MSEXT	GO:0016491	oxidoreductase activity	Gains
MSEXT	GO:0038023	signaling receptor activity	Gains
MSEXT	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
MSEXT	GO:0004888	transmembrane signaling receptor activity	Gains
MSEXT	GO:0015294	solute:cation symporter activity	Gains
MSEXT	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
MSEXT	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
MSEXT	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
MSEXT	GO:0033041	sweet taste receptor activity	Gains
MSEXT	GO:0018685	alkane 1-monooxygenase activity	Gains
MSEXT	GO:0005222	intracellular cAMP activated cation channel activity	Gains
MSEXT	GO:0005223	intracellular cGMP activated cation channel activity	Gains
MSEXT	GO:0005212	structural constituent of eye lens	Gains
MSEXT	GO:0050591	quinine 3-monooxygenase activity	Gains
MSEXT	GO:0005213	structural constituent of chorion	Gains
MSEXT	GO:0030551	cyclic nucleotide binding	Gains
MSEXT	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
MSEXT	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
MSEXT	GO:0097159	organic cyclic compound binding	Gains
MSEXT	GO:1901363	heterocyclic compound binding	Gains
MSEXT	GO:0008233	peptidase activity	Gains
MSEXT	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
MSEXT	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
MSEXT	GO:0004129	cytochrome-c oxidase activity	Gains
MSEXT	GO:0015002	heme-copper terminal oxidase activity	Gains
MSEXT	GO:0042302	structural constituent of cuticle	Gains
MSEXT	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Gains
MSEXT	GO:0046914	transition metal ion binding	Gains
MSEXT	GO:0004692	cGMP-dependent protein kinase activity	Gains
MSEXT	GO:0005343	organic acid:sodium symporter activity	Gains
MSEXT	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
MSEXT	GO:0004175	endopeptidase activity	Gains
MSEXT	GO:0061134	peptidase regulator activity	Gains
MSEXT	GO:0005326	neurotransmitter transporter activity	Gains
MSEXT	GO:0015293	symporter activity	Gains
MSEXT	GO:0015926	glucosidase activity	Gains
MSEXT	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
MSEXT	GO:0004521	endoribonuclease activity	Gains
MSEXT	GO:0004736	pyruvate carboxylase activity	Gains
MSEXT	GO:0043855	cyclic nucleotide-gated ion channel activity	Gains
MSEXT	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
MSEXT	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Gains
MSEXT	GO:1901618	organic hydroxy compound transmembrane transporter activity	Gains
MSEXT	GO:0004497	monooxygenase activity	Gains
MSEXT	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
MSEXT	GO:0004518	nuclease activity	Gains
MSEXT	GO:0004857	enzyme inhibitor activity	Gains
MSEXT	GO:0015923	mannosidase activity	Losses
MSEXT	GO:0004559	alpha-mannosidase activity	Losses
MSEXT	GO:0004852	uroporphyrinogen-III synthase activity	Losses
MSEXT	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Losses
MSEXT	GO:0046872	metal ion binding	Losses
MSEXT	GO:0005509	calcium ion binding	Losses
MSEXT	GO:0043169	cation binding	Losses
MSEXT	GO:0015924	mannosyl-oligosaccharide mannosidase activity	Losses
MSEXT	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Losses
MSEXT	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
MSEXT	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
MSEXT	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
MSEXT	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
MSEXT	GO:0008860	ferredoxin-NAD+ reductase activity	Losses
MSEXT	GO:0005272	sodium channel activity	Losses
MSEXT	GO:0004519	endonuclease activity	Losses
MSEXT	GO:0004532	exoribonuclease activity	Losses
MSEXT	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Losses
MSEXT	GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors	Losses
MSEXT	GO:0016731	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	Losses
MSEXT	GO:0009881	photoreceptor activity	Losses
MSEXT	GO:0004518	nuclease activity	Losses
MSEXT	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
MSEXT	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	Losses
MSEXT	GO:0008859	exoribonuclease II activity	Losses
MSEXT	GO:0004540	ribonuclease activity	Losses
MSEXT	GO:0016787	hydrolase activity	Losses
MSEXT	GO:0005216	ion channel activity	Losses
MSEXT	GO:0022838	substrate-specific channel activity	Losses
MSEXT	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Extinctions
MSEXT	GO:0015923	mannosidase activity	Extinctions
MSEXT	GO:0004559	alpha-mannosidase activity	Extinctions
MSEXT	GO:0004519	endonuclease activity	Extinctions
MSEXT	GO:0004520	endodeoxyribonuclease activity	Extinctions
MSEXT	GO:0004518	nuclease activity	Extinctions
MSEXT	GO:0015924	mannosyl-oligosaccharide mannosidase activity	Extinctions
MSEXT	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
MSEXT	GO:0004532	exoribonuclease activity	Extinctions
MSEXT	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
MSEXT	GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Extinctions
MSEXT	GO:0070064	proline-rich region binding	Extinctions
MSEXT	GO:0016618	hydroxypyruvate reductase activity	Extinctions
MSEXT	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
MSEXT	GO:0001784	phosphotyrosine residue binding	Extinctions
MSEXT	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Extinctions
MSEXT	GO:0004561	alpha-N-acetylglucosaminidase activity	Extinctions
MSEXT	GO:0019784	NEDD8-specific protease activity	Extinctions
MSEXT	GO:0000700	mismatch base pair DNA N-glycosylase activity	Extinctions
MSEXT	GO:0044748	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	Extinctions
MSEXT	GO:0004020	adenylylsulfate kinase activity	Extinctions
MSEXT	GO:0004038	allantoinase activity	Extinctions
MSEXT	GO:0016152	mercury (II) reductase activity	Extinctions
MSEXT	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Extinctions
MSEXT	GO:0005164	tumor necrosis factor receptor binding	Extinctions
MSEXT	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Extinctions
MSEXT	GO:0050262	ribosylnicotinamide kinase activity	Extinctions
MSEXT	GO:0008798	beta-aspartyl-peptidase activity	Extinctions
MSEXT	GO:0004163	diphosphomevalonate decarboxylase activity	Extinctions
MSEXT	GO:0050897	cobalt ion binding	Extinctions
MSEXT	GO:0008887	glycerate kinase activity	Extinctions
MSEXT	GO:0045309	protein phosphorylated amino acid binding	Extinctions
MSEXT	GO:0032813	tumor necrosis factor receptor superfamily binding	Extinctions
30	GO:0003964	RNA-directed DNA polymerase activity	Gains
30	GO:0034061	DNA polymerase activity	Gains
30	GO:0140097	catalytic activity, acting on DNA	Gains
30	GO:0016779	nucleotidyltransferase activity	Gains
30	GO:0003676	nucleic acid binding	Gains
30	GO:0070001	aspartic-type peptidase activity	Gains
30	GO:0004190	aspartic-type endopeptidase activity	Gains
30	GO:0008270	zinc ion binding	Gains
30	GO:1901363	heterocyclic compound binding	Gains
30	GO:0097159	organic cyclic compound binding	Gains
30	GO:0004175	endopeptidase activity	Gains
30	GO:0046914	transition metal ion binding	Gains
30	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
30	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
30	GO:0022857	transmembrane transporter activity	Gains
30	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
30	GO:0004519	endonuclease activity	Gains
30	GO:0005549	odorant binding	Gains
30	GO:0008233	peptidase activity	Gains
30	GO:0003677	DNA binding	Gains
30	GO:0005249	voltage-gated potassium channel activity	Gains
30	GO:0046872	metal ion binding	Gains
30	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
30	GO:0004518	nuclease activity	Gains
30	GO:0043169	cation binding	Gains
30	GO:0022891	substrate-specific transmembrane transporter activity	Gains
30	GO:0008324	cation transmembrane transporter activity	Gains
30	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
30	GO:0022843	voltage-gated cation channel activity	Gains
30	GO:0022890	inorganic cation transmembrane transporter activity	Gains
30	GO:0015075	ion transmembrane transporter activity	Gains
30	GO:0005267	potassium channel activity	Gains
30	GO:0008812	choline dehydrogenase activity	Gains
30	GO:0005452	inorganic anion exchanger activity	Gains
30	GO:0015079	potassium ion transmembrane transporter activity	Gains
30	GO:0015927	trehalase activity	Gains
30	GO:0004555	alpha,alpha-trehalase activity	Gains
30	GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
30	GO:0070548	L-glutamine aminotransferase activity	Gains
30	GO:0004457	lactate dehydrogenase activity	Gains
30	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Gains
30	GO:0005215	transporter activity	Gains
30	GO:0005244	voltage-gated ion channel activity	Gains
30	GO:0022832	voltage-gated channel activity	Gains
30	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
30	GO:0004984	olfactory receptor activity	Gains
30	GO:0042302	structural constituent of cuticle	Gains
30	GO:0022892	substrate-specific transporter activity	Gains
30	GO:0050660	flavin adenine dinucleotide binding	Gains
30	GO:0008236	serine-type peptidase activity	Gains
30	GO:0099600	transmembrane receptor activity	Gains
30	GO:0004075	biotin carboxylase activity	Gains
30	GO:0004016	adenylate cyclase activity	Gains
30	GO:0017171	serine hydrolase activity	Gains
30	GO:0004594	pantothenate kinase activity	Gains
30	GO:0004888	transmembrane signaling receptor activity	Gains
30	GO:0004521	endoribonuclease activity	Gains
30	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
30	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
30	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Gains
30	GO:0046873	metal ion transmembrane transporter activity	Gains
30	GO:0005215	transporter activity	Losses
30	GO:0042625	ATPase coupled ion transmembrane transporter activity	Losses
30	GO:0050254	rhodopsin kinase activity	Losses
30	GO:0043492	ATPase activity, coupled to movement of substances	Losses
30	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
30	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Losses
30	GO:0015604	organic phosphonate transmembrane transporter activity	Losses
30	GO:0015399	primary active transmembrane transporter activity	Losses
30	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
30	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
30	GO:0022857	transmembrane transporter activity	Losses
30	GO:0022853	active ion transmembrane transporter activity	Losses
30	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
30	GO:0008144	drug binding	Losses
30	GO:0035237	corazonin receptor activity	Losses
30	GO:0046790	virion binding	Losses
30	GO:0004598	peptidylamidoglycolate lyase activity	Losses
30	GO:0008908	isochorismatase activity	Losses
30	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
30	GO:0004061	arylformamidase activity	Losses
30	GO:0050093	methanol dehydrogenase activity	Losses
30	GO:0072320	volume-sensitive chloride channel activity	Losses
30	GO:0019811	cocaine binding	Losses
30	GO:0015222	serotonin transmembrane transporter activity	Losses
30	GO:0070742	C2H2 zinc finger domain binding	Losses
30	GO:0005329	dopamine transmembrane transporter activity	Losses
30	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity	Losses
30	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Losses
30	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Losses
30	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Losses
30	GO:0004392	heme oxygenase (decyclizing) activity	Losses
30	GO:0004359	glutaminase activity	Losses
30	GO:0004474	malate synthase activity	Losses
30	GO:0042071	leucokinin receptor activity	Losses
30	GO:0005225	volume-sensitive anion channel activity	Losses
30	GO:0042943	D-amino acid transmembrane transporter activity	Losses
30	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
30	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
30	GO:0008509	anion transmembrane transporter activity	Losses
30	GO:0015605	organophosphate ester transmembrane transporter activity	Losses
30	GO:0019829	cation-transporting ATPase activity	Losses
30	GO:0008188	neuropeptide receptor activity	Losses
30	GO:0004983	neuropeptide Y receptor activity	Losses
30	GO:0022891	substrate-specific transmembrane transporter activity	Losses
30	GO:0022804	active transmembrane transporter activity	Losses
30	GO:0050591	quinine 3-monooxygenase activity	Losses
30	GO:0050699	WW domain binding	Losses
30	GO:0070405	ammonium ion binding	Losses
30	GO:0001094	TFIID-class transcription factor binding	Losses
30	GO:0070888	E-box binding	Losses
30	GO:0004371	glycerone kinase activity	Losses
30	GO:0004333	fumarate hydratase activity	Losses
30	GO:0097003	adipokinetic hormone receptor activity	Losses
30	GO:0097004	adipokinetic hormone binding	Losses
30	GO:0004140	dephospho-CoA kinase activity	Losses
30	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
30	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Losses
30	GO:0008504	monoamine transmembrane transporter activity	Losses
30	GO:0008528	G-protein coupled peptide receptor activity	Losses
30	GO:0005549	odorant binding	Novel expansions
30	GO:0004252	serine-type endopeptidase activity	Novel expansions
30	GO:0008270	zinc ion binding	Novel expansions
30	GO:0008236	serine-type peptidase activity	Novel expansions
30	GO:0017171	serine hydrolase activity	Novel expansions
30	GO:0046914	transition metal ion binding	Novel expansions
30	GO:0005242	inward rectifier potassium channel activity	Novel expansions
30	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Novel expansions
30	GO:0099600	transmembrane receptor activity	Novel expansions
30	GO:0004930	G-protein coupled receptor activity	Novel expansions
30	GO:0019829	cation-transporting ATPase activity	Extinctions
30	GO:0008188	neuropeptide receptor activity	Extinctions
30	GO:0035237	corazonin receptor activity	Extinctions
30	GO:0008908	isochorismatase activity	Extinctions
30	GO:0004061	arylformamidase activity	Extinctions
30	GO:0050093	methanol dehydrogenase activity	Extinctions
30	GO:0070742	C2H2 zinc finger domain binding	Extinctions
30	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity	Extinctions
30	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
30	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Extinctions
30	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
30	GO:0004392	heme oxygenase (decyclizing) activity	Extinctions
30	GO:0004359	glutaminase activity	Extinctions
30	GO:0042071	leucokinin receptor activity	Extinctions
30	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Extinctions
30	GO:0043492	ATPase activity, coupled to movement of substances	Extinctions
30	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Extinctions
30	GO:0042625	ATPase coupled ion transmembrane transporter activity	Extinctions
30	GO:0004983	neuropeptide Y receptor activity	Extinctions
30	GO:0015399	primary active transmembrane transporter activity	Extinctions
30	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Extinctions
30	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Extinctions
30	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
30	GO:0001653	peptide receptor activity	Extinctions
30	GO:0005215	transporter activity	Extinctions
30	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
30	GO:0022853	active ion transmembrane transporter activity	Extinctions
30	GO:0050254	rhodopsin kinase activity	Extinctions
30	GO:0001094	TFIID-class transcription factor binding	Extinctions
30	GO:0004371	glycerone kinase activity	Extinctions
30	GO:0004333	fumarate hydratase activity	Extinctions
30	GO:0097003	adipokinetic hormone receptor activity	Extinctions
30	GO:0097004	adipokinetic hormone binding	Extinctions
30	GO:0004140	dephospho-CoA kinase activity	Extinctions
30	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Extinctions
30	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Extinctions
35	GO:0005215	transporter activity	Gains
35	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
35	GO:0005351	sugar:proton symporter activity	Gains
35	GO:0005402	cation:sugar symporter activity	Gains
35	GO:0015295	solute:proton symporter activity	Gains
35	GO:0022857	transmembrane transporter activity	Gains
35	GO:0015144	carbohydrate transmembrane transporter activity	Gains
35	GO:0051119	sugar transmembrane transporter activity	Gains
35	GO:0015291	secondary active transmembrane transporter activity	Gains
35	GO:0016209	antioxidant activity	Gains
35	GO:0022804	active transmembrane transporter activity	Gains
35	GO:0000156	phosphorelay response regulator activity	Gains
35	GO:0015293	symporter activity	Gains
35	GO:0008324	cation transmembrane transporter activity	Gains
35	GO:0003824	catalytic activity	Gains
35	GO:0004602	glutathione peroxidase activity	Gains
35	GO:0015294	solute:cation symporter activity	Gains
35	GO:0022892	substrate-specific transporter activity	Gains
35	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
35	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
35	GO:0004601	peroxidase activity	Gains
35	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
35	GO:0003993	acid phosphatase activity	Gains
35	GO:0022891	substrate-specific transmembrane transporter activity	Gains
35	GO:0030554	adenyl nucleotide binding	Gains
35	GO:0016829	lyase activity	Gains
35	GO:0008475	procollagen-lysine 5-dioxygenase activity	Gains
35	GO:0033041	sweet taste receptor activity	Gains
35	GO:0005212	structural constituent of eye lens	Gains
35	GO:0005242	inward rectifier potassium channel activity	Gains
35	GO:0004753	saccharopine dehydrogenase activity	Gains
35	GO:0019136	deoxynucleoside kinase activity	Gains
35	GO:0004706	JUN kinase kinase kinase activity	Gains
35	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
35	GO:0015075	ion transmembrane transporter activity	Gains
35	GO:0008061	chitin binding	Gains
35	GO:0005524	ATP binding	Gains
35	GO:0032559	adenyl ribonucleotide binding	Gains
35	GO:0099516	ion antiporter activity	Gains
35	GO:0099094	ligand-gated cation channel activity	Gains
35	GO:0015297	antiporter activity	Gains
35	GO:0019842	vitamin binding	Gains
35	GO:0046873	metal ion transmembrane transporter activity	Gains
35	GO:0043168	anion binding	Gains
35	GO:0016491	oxidoreductase activity	Gains
35	GO:0016849	phosphorus-oxygen lyase activity	Gains
35	GO:0097367	carbohydrate derivative binding	Gains
35	GO:0048037	cofactor binding	Gains
35	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	Gains
35	GO:0019206	nucleoside kinase activity	Gains
35	GO:0015298	solute:cation antiporter activity	Gains
35	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
35	GO:0099604	ligand-gated calcium channel activity	Gains
35	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
35	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
35	GO:0015037	peptide disulfide oxidoreductase activity	Gains
35	GO:0015038	glutathione disulfide oxidoreductase activity	Gains
35	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Gains
35	GO:0015278	calcium-release channel activity	Gains
35	GO:0017076	purine nucleotide binding	Gains
35	GO:0003725	double-stranded RNA binding	Gains
35	GO:0000155	phosphorelay sensor kinase activity	Gains
35	GO:0004673	protein histidine kinase activity	Gains
35	GO:0032296	double-stranded RNA-specific ribonuclease activity	Gains
35	GO:0015491	cation:cation antiporter activity	Gains
35	GO:0004525	ribonuclease III activity	Gains
35	GO:0036094	small molecule binding	Gains
35	GO:0005262	calcium channel activity	Gains
35	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
35	GO:0005201	extracellular matrix structural constituent	Gains
35	GO:0004222	metalloendopeptidase activity	Gains
35	GO:0035639	purine ribonucleoside triphosphate binding	Gains
35	GO:0022843	voltage-gated cation channel activity	Gains
35	GO:0017002	activin-activated receptor activity	Losses
35	GO:0005024	transforming growth factor beta-activated receptor activity	Losses
35	GO:0048185	activin binding	Losses
35	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Losses
35	GO:0004725	protein tyrosine phosphatase activity	Losses
35	GO:0003700	DNA binding transcription factor activity	Losses
35	GO:0140110	transcription regulator activity	Losses
35	GO:0035197	siRNA binding	Losses
35	GO:0030165	PDZ domain binding	Losses
35	GO:0038023	signaling receptor activity	Losses
35	GO:0005515	protein binding	Losses
35	GO:0004872	receptor activity	Losses
35	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
35	GO:0016417	S-acyltransferase activity	Losses
35	GO:0043015	gamma-tubulin binding	Losses
35	GO:0008061	chitin binding	Losses
35	GO:0060089	molecular transducer activity	Losses
35	GO:0031490	chromatin DNA binding	Losses
35	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Losses
35	GO:0003676	nucleic acid binding	Novel expansions
35	GO:0046872	metal ion binding	Novel expansions
35	GO:0043169	cation binding	Novel expansions
35	GO:0003910	DNA ligase (ATP) activity	Novel expansions
35	GO:0003909	DNA ligase activity	Novel expansions
35	GO:0030165	PDZ domain binding	Extinctions
35	GO:0004725	protein tyrosine phosphatase activity	Extinctions
35	GO:0016417	S-acyltransferase activity	Extinctions
35	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Extinctions
35	GO:0019706	protein-cysteine S-palmitoyltransferase activity	Extinctions
35	GO:0019707	protein-cysteine S-acyltransferase activity	Extinctions
35	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
35	GO:0000339	RNA cap binding	Extinctions
35	GO:0140110	transcription regulator activity	Extinctions
34	GO:0005549	odorant binding	Gains
34	GO:0008236	serine-type peptidase activity	Gains
34	GO:0004984	olfactory receptor activity	Gains
34	GO:0017171	serine hydrolase activity	Gains
34	GO:0004252	serine-type endopeptidase activity	Gains
34	GO:0005215	transporter activity	Gains
34	GO:0022857	transmembrane transporter activity	Gains
34	GO:0004888	transmembrane signaling receptor activity	Gains
34	GO:0008812	choline dehydrogenase activity	Gains
34	GO:0099600	transmembrane receptor activity	Gains
34	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
34	GO:0003964	RNA-directed DNA polymerase activity	Gains
34	GO:0038023	signaling receptor activity	Gains
34	GO:0004930	G-protein coupled receptor activity	Gains
34	GO:0008233	peptidase activity	Gains
34	GO:0005213	structural constituent of chorion	Gains
34	GO:0004180	carboxypeptidase activity	Gains
34	GO:0004175	endopeptidase activity	Gains
34	GO:0016615	malate dehydrogenase activity	Gains
34	GO:0046872	metal ion binding	Gains
34	GO:0043169	cation binding	Gains
34	GO:0005272	sodium channel activity	Gains
34	GO:0004872	receptor activity	Gains
34	GO:0008238	exopeptidase activity	Gains
34	GO:0008889	glycerophosphodiester phosphodiesterase activity	Gains
34	GO:0004185	serine-type carboxypeptidase activity	Gains
34	GO:0034061	DNA polymerase activity	Gains
34	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
34	GO:0005200	structural constituent of cytoskeleton	Gains
34	GO:0015081	sodium ion transmembrane transporter activity	Gains
34	GO:0070008	serine-type exopeptidase activity	Gains
34	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	Gains
34	GO:0003945	N-acetyllactosamine synthase activity	Gains
34	GO:0051032	nucleic acid transmembrane transporter activity	Gains
34	GO:0051033	RNA transmembrane transporter activity	Gains
34	GO:0004096	catalase activity	Gains
34	GO:0030523	dihydrolipoamide S-acyltransferase activity	Gains
34	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Gains
34	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
34	GO:0030060	L-malate dehydrogenase activity	Gains
34	GO:0008270	zinc ion binding	Gains
34	GO:0004970	ionotropic glutamate receptor activity	Gains
34	GO:0022824	transmitter-gated ion channel activity	Gains
34	GO:0022835	transmitter-gated channel activity	Gains
34	GO:0060089	molecular transducer activity	Gains
34	GO:0004181	metallocarboxypeptidase activity	Gains
34	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
34	GO:0046914	transition metal ion binding	Gains
34	GO:0004871	signal transducer activity	Gains
34	GO:0019840	isoprenoid binding	Gains
34	GO:0008066	glutamate receptor activity	Gains
34	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
34	GO:0004629	phospholipase C activity	Gains
34	GO:0015103	inorganic anion transmembrane transporter activity	Losses
34	GO:0018685	alkane 1-monooxygenase activity	Losses
34	GO:0004692	cGMP-dependent protein kinase activity	Losses
34	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
34	GO:0005044	scavenger receptor activity	Losses
34	GO:0046914	transition metal ion binding	Losses
34	GO:0005251	delayed rectifier potassium channel activity	Losses
34	GO:0020037	heme binding	Losses
34	GO:0005254	chloride channel activity	Losses
34	GO:0038024	cargo receptor activity	Losses
34	GO:0046906	tetrapyrrole binding	Losses
34	GO:0060089	molecular transducer activity	Losses
34	GO:0008270	zinc ion binding	Losses
34	GO:0005253	anion channel activity	Losses
34	GO:0015291	secondary active transmembrane transporter activity	Losses
34	GO:0015108	chloride transmembrane transporter activity	Losses
34	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
34	GO:0004175	endopeptidase activity	Losses
34	GO:0005506	iron ion binding	Losses
34	GO:0052689	carboxylic ester hydrolase activity	Losses
34	GO:0008603	cAMP-dependent protein kinase regulator activity	Losses
34	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
34	GO:0043169	cation binding	Losses
34	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
34	GO:0004872	receptor activity	Losses
34	GO:0070330	aromatase activity	Losses
34	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
34	GO:0030170	pyridoxal phosphate binding	Losses
34	GO:0015293	symporter activity	Losses
34	GO:0070279	vitamin B6 binding	Losses
34	GO:0008509	anion transmembrane transporter activity	Losses
34	GO:0017048	Rho GTPase binding	Losses
34	GO:0004497	monooxygenase activity	Losses
34	GO:0005539	glycosaminoglycan binding	Losses
34	GO:0046872	metal ion binding	Losses
34	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Losses
34	GO:0035237	corazonin receptor activity	Losses
34	GO:0032038	myosin II heavy chain binding	Losses
34	GO:0000254	C-4 methylsterol oxidase activity	Losses
34	GO:0000257	nitrilase activity	Losses
34	GO:0004556	alpha-amylase activity	Losses
34	GO:0042165	neurotransmitter binding	Losses
34	GO:0042166	acetylcholine binding	Losses
34	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Losses
34	GO:0015499	formate transmembrane transporter activity	Losses
34	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
34	GO:0046583	cation efflux transmembrane transporter activity	Losses
34	GO:0052870	tocopherol omega-hydroxylase activity	Losses
34	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
34	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Losses
34	GO:0016933	extracellularly glycine-gated ion channel activity	Losses
34	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Losses
34	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Losses
34	GO:0015106	bicarbonate transmembrane transporter activity	Losses
34	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
34	GO:0072320	volume-sensitive chloride channel activity	Losses
34	GO:0018738	S-formylglutathione hydrolase activity	Losses
34	GO:0047886	farnesol dehydrogenase activity	Losses
34	GO:0019531	oxalate transmembrane transporter activity	Losses
34	GO:0043715	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity	Losses
34	GO:0043716	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity	Losses
34	GO:0016160	amylase activity	Losses
34	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	Losses
34	GO:0061778	intracellular chloride channel activity	Losses
34	GO:0004465	lipoprotein lipase activity	Losses
34	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
34	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	Losses
34	GO:0005225	volume-sensitive anion channel activity	Losses
34	GO:0005229	intracellular calcium activated chloride channel activity	Losses
34	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Losses
34	GO:0022883	zinc efflux transmembrane transporter activity	Losses
34	GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	Losses
34	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Losses
34	GO:0015098	molybdate ion transmembrane transporter activity	Losses
34	GO:0004796	thromboxane-A synthase activity	Losses
34	GO:0008579	JUN kinase phosphatase activity	Losses
34	GO:0017159	pantetheine hydrolase activity	Losses
34	GO:0004672	protein kinase activity	Losses
34	GO:0001871	pattern binding	Losses
34	GO:0004622	lysophospholipase activity	Losses
34	GO:0030247	polysaccharide binding	Losses
34	GO:0015075	ion transmembrane transporter activity	Losses
34	GO:0009055	electron transfer activity	Losses
34	GO:0008236	serine-type peptidase activity	Novel expansions
34	GO:0017171	serine hydrolase activity	Novel expansions
34	GO:0004252	serine-type endopeptidase activity	Novel expansions
34	GO:0070011	peptidase activity, acting on L-amino acid peptides	Novel expansions
34	GO:0004175	endopeptidase activity	Novel expansions
34	GO:0008233	peptidase activity	Novel expansions
34	GO:0043169	cation binding	Novel expansions
34	GO:0046872	metal ion binding	Novel expansions
34	GO:0004984	olfactory receptor activity	Novel expansions
34	GO:0005549	odorant binding	Novel expansions
34	GO:0008812	choline dehydrogenase activity	Novel expansions
34	GO:0004185	serine-type carboxypeptidase activity	Novel expansions
34	GO:0022857	transmembrane transporter activity	Novel expansions
34	GO:0070008	serine-type exopeptidase activity	Novel expansions
34	GO:0004356	glutamate-ammonia ligase activity	Novel expansions
34	GO:0016211	ammonia ligase activity	Novel expansions
34	GO:0004180	carboxypeptidase activity	Novel expansions
34	GO:0005242	inward rectifier potassium channel activity	Novel expansions
34	GO:0016880	acid-ammonia (or amide) ligase activity	Novel expansions
34	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Novel expansions
34	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Novel expansions
34	GO:0005215	transporter activity	Novel expansions
34	GO:0008237	metallopeptidase activity	Novel expansions
34	GO:0008238	exopeptidase activity	Novel expansions
34	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Extinctions
34	GO:0032038	myosin II heavy chain binding	Extinctions
34	GO:0000254	C-4 methylsterol oxidase activity	Extinctions
34	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Extinctions
34	GO:0046583	cation efflux transmembrane transporter activity	Extinctions
34	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Extinctions
34	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Extinctions
34	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Extinctions
34	GO:0018738	S-formylglutathione hydrolase activity	Extinctions
34	GO:0043715	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity	Extinctions
34	GO:0043716	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity	Extinctions
34	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
34	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	Extinctions
34	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Extinctions
34	GO:0022883	zinc efflux transmembrane transporter activity	Extinctions
34	GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	Extinctions
34	GO:0015098	molybdate ion transmembrane transporter activity	Extinctions
34	GO:0008579	JUN kinase phosphatase activity	Extinctions
34	GO:0008270	zinc ion binding	Extinctions
34	GO:0008376	acetylgalactosaminyltransferase activity	Extinctions
34	GO:0046914	transition metal ion binding	Extinctions
34	GO:0008236	serine-type peptidase activity	Extinctions
34	GO:0017171	serine hydrolase activity	Extinctions
34	GO:0004252	serine-type endopeptidase activity	Extinctions
34	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Extinctions
34	GO:0032033	myosin II light chain binding	Extinctions
34	GO:0017057	6-phosphogluconolactonase activity	Extinctions
34	GO:0051371	muscle alpha-actinin binding	Extinctions
34	GO:0046923	ER retention sequence binding	Extinctions
34	GO:0015562	efflux transmembrane transporter activity	Extinctions
34	GO:0043874	acireductone synthase activity	Extinctions
34	GO:0008897	holo-[acyl-carrier-protein] synthase activity	Extinctions
34	GO:0008010	structural constituent of chitin-based larval cuticle	Extinctions
HY1	GO:0003676	nucleic acid binding	Gains
HY1	GO:0003677	DNA binding	Gains
HY1	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY1	GO:0034061	DNA polymerase activity	Gains
HY1	GO:0045134	uridine-diphosphatase activity	Gains
HY1	GO:0017110	nucleoside-diphosphatase activity	Gains
HY1	GO:1901363	heterocyclic compound binding	Gains
HY1	GO:0097159	organic cyclic compound binding	Gains
HY1	GO:0004000	adenosine deaminase activity	Gains
HY1	GO:0005267	potassium channel activity	Gains
HY1	GO:0016779	nucleotidyltransferase activity	Gains
HY1	GO:0005249	voltage-gated potassium channel activity	Gains
HY1	GO:0022803	passive transmembrane transporter activity	Gains
HY1	GO:0015267	channel activity	Gains
HY1	GO:0019199	transmembrane receptor protein kinase activity	Gains
HY1	GO:0015079	potassium ion transmembrane transporter activity	Gains
HY1	GO:0003990	acetylcholinesterase activity	Gains
HY1	GO:0004104	cholinesterase activity	Gains
HY1	GO:0003700	DNA binding transcription factor activity	Gains
HY1	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
HY1	GO:0019239	deaminase activity	Gains
HY1	GO:0030628	pre-mRNA 3'-splice site binding	Gains
HY1	GO:0004517	nitric-oxide synthase activity	Gains
HY1	GO:0005025	transforming growth factor beta receptor activity, type I	Gains
HY1	GO:0005003	ephrin receptor activity	Gains
HY1	GO:0016361	activin receptor activity, type I	Gains
HY1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Gains
HY1	GO:0050431	transforming growth factor beta binding	Gains
HY1	GO:0004061	arylformamidase activity	Gains
HY1	GO:0016155	formyltetrahydrofolate dehydrogenase activity	Gains
HY1	GO:0005216	ion channel activity	Gains
HY1	GO:0022838	substrate-specific channel activity	Gains
HY1	GO:0022843	voltage-gated cation channel activity	Gains
HY1	GO:0004623	phospholipase A2 activity	Gains
HY1	GO:0061135	endopeptidase regulator activity	Gains
HY1	GO:0022836	gated channel activity	Gains
HY1	GO:0004518	nuclease activity	Gains
HY1	GO:0052689	carboxylic ester hydrolase activity	Gains
HY1	GO:0004872	receptor activity	Gains
HY1	GO:0005416	cation:amino acid symporter activity	Losses
HY1	GO:0005283	sodium:amino acid symporter activity	Losses
HY1	GO:0016209	antioxidant activity	Losses
HY1	GO:0005179	hormone activity	Losses
HY1	GO:0015179	L-amino acid transmembrane transporter activity	Losses
HY1	GO:0005343	organic acid:sodium symporter activity	Losses
HY1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
HY1	GO:0008017	microtubule binding	Losses
HY1	GO:0016779	nucleotidyltransferase activity	Losses
HY1	GO:1901682	sulfur compound transmembrane transporter activity	Losses
HY1	GO:0004364	glutathione transferase activity	Losses
HY1	GO:0015631	tubulin binding	Losses
HY1	GO:0022857	transmembrane transporter activity	Losses
HY1	GO:0050093	methanol dehydrogenase activity	Losses
HY1	GO:0019811	cocaine binding	Losses
HY1	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
HY1	GO:0004587	ornithine-oxo-acid transaminase activity	Losses
HY1	GO:0004528	phosphodiesterase I activity	Losses
HY1	GO:0003986	acetyl-CoA hydrolase activity	Losses
HY1	GO:0032542	sulfiredoxin activity	Losses
HY1	GO:0003919	FMN adenylyltransferase activity	Losses
HY1	GO:0015222	serotonin transmembrane transporter activity	Losses
HY1	GO:0004667	prostaglandin-D synthase activity	Losses
HY1	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
HY1	GO:0008936	nicotinamidase activity	Losses
HY1	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
HY1	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
HY1	GO:0018834	dichloromethane dehalogenase activity	Losses
HY1	GO:0016415	octanoyltransferase activity	Losses
HY1	GO:0035237	corazonin receptor activity	Losses
HY1	GO:0004055	argininosuccinate synthase activity	Losses
HY1	GO:0033819	lipoyl(octanoyl) transferase activity	Losses
HY1	GO:0005368	taurine transmembrane transporter activity	Losses
HY1	GO:0005369	taurine:sodium symporter activity	Losses
HY1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
HY1	GO:0005329	dopamine transmembrane transporter activity	Losses
HY1	GO:0031434	mitogen-activated protein kinase kinase binding	Losses
HY1	GO:0045735	nutrient reservoir activity	Losses
HY1	GO:0042943	D-amino acid transmembrane transporter activity	Losses
HY1	GO:0035529	NADH pyrophosphatase activity	Losses
HY1	GO:0047964	glyoxylate reductase activity	Losses
HY1	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
HY1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Losses
HY1	GO:0005122	torso binding	Losses
HY1	GO:0050700	CARD domain binding	Losses
HY1	GO:0004339	glucan 1,4-alpha-glucosidase activity	Losses
HY1	GO:0000016	lactase activity	Losses
HY1	GO:0004459	L-lactate dehydrogenase activity	Losses
HY1	GO:0030267	glyoxylate reductase (NADP) activity	Losses
HY1	GO:0008873	gluconate 2-dehydrogenase activity	Losses
HY1	GO:0008875	gluconate dehydrogenase activity	Losses
HY1	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
HY1	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
HY1	GO:0052834	inositol monophosphate phosphatase activity	Losses
HY1	GO:0019182	histamine-gated chloride channel activity	Losses
HY1	GO:0004170	dUTP diphosphatase activity	Losses
HY1	GO:0004131	cytosine deaminase activity	Losses
HY1	GO:0008536	Ran GTPase binding	Losses
HY1	GO:0005550	pheromone binding	Losses
HY1	GO:0005534	galactose binding	Losses
HY1	GO:0018445	prothoracicotrophic hormone activity	Losses
HY1	GO:0004930	G-protein coupled receptor activity	Losses
HY1	GO:0004222	metalloendopeptidase activity	Losses
HY1	GO:0015171	amino acid transmembrane transporter activity	Losses
HY1	GO:0016408	C-acyltransferase activity	Losses
HY1	GO:0034061	DNA polymerase activity	Losses
HY1	GO:0038023	signaling receptor activity	Losses
HY1	GO:0004871	signal transducer activity	Losses
HY1	GO:0005179	hormone activity	Extinctions
HY1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
HY1	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY1	GO:0038023	signaling receptor activity	Extinctions
HY1	GO:0004930	G-protein coupled receptor activity	Extinctions
HY1	GO:0004871	signal transducer activity	Extinctions
HY1	GO:0099600	transmembrane receptor activity	Extinctions
HY1	GO:0048018	receptor ligand activity	Extinctions
HY1	GO:0016408	C-acyltransferase activity	Extinctions
HY1	GO:0004528	phosphodiesterase I activity	Extinctions
HY1	GO:0032542	sulfiredoxin activity	Extinctions
HY1	GO:0008934	inositol monophosphate 1-phosphatase activity	Extinctions
HY1	GO:0018834	dichloromethane dehalogenase activity	Extinctions
HY1	GO:0035237	corazonin receptor activity	Extinctions
HY1	GO:0004055	argininosuccinate synthase activity	Extinctions
HY1	GO:0031434	mitogen-activated protein kinase kinase binding	Extinctions
HY1	GO:0035529	NADH pyrophosphatase activity	Extinctions
HY1	GO:0005122	torso binding	Extinctions
HY1	GO:0050700	CARD domain binding	Extinctions
HY1	GO:0004339	glucan 1,4-alpha-glucosidase activity	Extinctions
HY1	GO:0000016	lactase activity	Extinctions
HY1	GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
HY1	GO:0008875	gluconate dehydrogenase activity	Extinctions
HY1	GO:0052832	inositol monophosphate 3-phosphatase activity	Extinctions
HY1	GO:0052833	inositol monophosphate 4-phosphatase activity	Extinctions
HY1	GO:0052834	inositol monophosphate phosphatase activity	Extinctions
HY1	GO:0004170	dUTP diphosphatase activity	Extinctions
HY1	GO:0008536	Ran GTPase binding	Extinctions
HY1	GO:0005550	pheromone binding	Extinctions
HY1	GO:0018445	prothoracicotrophic hormone activity	Extinctions
HY1	GO:0008017	microtubule binding	Extinctions
HY1	GO:0030545	receptor regulator activity	Extinctions
HY1	GO:0015631	tubulin binding	Extinctions
HY1	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Extinctions
HY1	GO:0008066	glutamate receptor activity	Extinctions
HY1	GO:0005184	neuropeptide hormone activity	Extinctions
HY1	GO:0015440	peptide-transporting ATPase activity	Extinctions
HY1	GO:0003997	acyl-CoA oxidase activity	Extinctions
HY1	GO:0003933	GTP cyclohydrolase activity	Extinctions
HY1	GO:0003934	GTP cyclohydrolase I activity	Extinctions
HY1	GO:0032050	clathrin heavy chain binding	Extinctions
HY1	GO:0015562	efflux transmembrane transporter activity	Extinctions
HY1	GO:0043539	protein serine/threonine kinase activator activity	Extinctions
HY1	GO:0016848	carbon-halide lyase activity	Extinctions
HY1	GO:0004496	mevalonate kinase activity	Extinctions
HY1	GO:0004447	iodide peroxidase activity	Extinctions
HY1	GO:0008890	glycine C-acetyltransferase activity	Extinctions
HY1	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
HY1	GO:0097003	adipokinetic hormone receptor activity	Extinctions
HY1	GO:0097004	adipokinetic hormone binding	Extinctions
AAEGY	GO:0030594	neurotransmitter receptor activity	Gains
AAEGY	GO:0022824	transmitter-gated ion channel activity	Gains
AAEGY	GO:0022835	transmitter-gated channel activity	Gains
AAEGY	GO:0004970	ionotropic glutamate receptor activity	Gains
AAEGY	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
AAEGY	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
AAEGY	GO:0008066	glutamate receptor activity	Gains
AAEGY	GO:0005549	odorant binding	Gains
AAEGY	GO:0005230	extracellular ligand-gated ion channel activity	Gains
AAEGY	GO:0022834	ligand-gated channel activity	Gains
AAEGY	GO:0015276	ligand-gated ion channel activity	Gains
AAEGY	GO:0022836	gated channel activity	Gains
AAEGY	GO:0004190	aspartic-type endopeptidase activity	Gains
AAEGY	GO:0070001	aspartic-type peptidase activity	Gains
AAEGY	GO:0004888	transmembrane signaling receptor activity	Gains
AAEGY	GO:0022803	passive transmembrane transporter activity	Gains
AAEGY	GO:0015267	channel activity	Gains
AAEGY	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
AAEGY	GO:0005216	ion channel activity	Gains
AAEGY	GO:0004252	serine-type endopeptidase activity	Gains
AAEGY	GO:0022838	substrate-specific channel activity	Gains
AAEGY	GO:0022857	transmembrane transporter activity	Gains
AAEGY	GO:0099600	transmembrane receptor activity	Gains
AAEGY	GO:0008174	mRNA methyltransferase activity	Gains
AAEGY	GO:0004568	chitinase activity	Gains
AAEGY	GO:0008270	zinc ion binding	Gains
AAEGY	GO:0022892	substrate-specific transporter activity	Gains
AAEGY	GO:0022891	substrate-specific transmembrane transporter activity	Gains
AAEGY	GO:0046914	transition metal ion binding	Gains
AAEGY	GO:0004175	endopeptidase activity	Gains
AAEGY	GO:0045735	nutrient reservoir activity	Gains
AAEGY	GO:0030151	molybdenum ion binding	Gains
AAEGY	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
AAEGY	GO:0038023	signaling receptor activity	Gains
AAEGY	GO:0008236	serine-type peptidase activity	Gains
AAEGY	GO:0017171	serine hydrolase activity	Gains
AAEGY	GO:0005215	transporter activity	Gains
AAEGY	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
AAEGY	GO:0015075	ion transmembrane transporter activity	Gains
AAEGY	GO:0004872	receptor activity	Gains
AAEGY	GO:0005212	structural constituent of eye lens	Gains
AAEGY	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Gains
AAEGY	GO:0017002	activin-activated receptor activity	Gains
AAEGY	GO:0008525	phosphatidylcholine transporter activity	Gains
AAEGY	GO:0051371	muscle alpha-actinin binding	Gains
AAEGY	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	Gains
AAEGY	GO:0048185	activin binding	Gains
AAEGY	GO:0003945	N-acetyllactosamine synthase activity	Gains
AAEGY	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
AAEGY	GO:0043546	molybdopterin cofactor binding	Gains
AAEGY	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
AAEGY	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Gains
AAEGY	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
AAEGY	GO:0018454	acetoacetyl-CoA reductase activity	Gains
AAEGY	GO:0030366	molybdopterin synthase activity	Gains
AAEGY	GO:0005125	cytokine activity	Gains
AAEGY	GO:0004871	signal transducer activity	Gains
AAEGY	GO:0060089	molecular transducer activity	Gains
AAEGY	GO:0042302	structural constituent of cuticle	Gains
AAEGY	GO:0036002	pre-mRNA binding	Gains
AAEGY	GO:0016630	protochlorophyllide reductase activity	Gains
AAEGY	GO:0015464	acetylcholine receptor activity	Gains
AAEGY	GO:0099528	G-protein coupled neurotransmitter receptor activity	Gains
AAEGY	GO:0004344	glucose dehydrogenase activity	Gains
AAEGY	GO:0016907	G-protein coupled acetylcholine receptor activity	Gains
AAEGY	GO:0004177	aminopeptidase activity	Gains
AAEGY	GO:0008061	chitin binding	Gains
AAEGY	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
AAEGY	GO:0016805	dipeptidase activity	Gains
AAEGY	GO:0008514	organic anion transmembrane transporter activity	Gains
AAEGY	GO:0005214	structural constituent of chitin-based cuticle	Gains
AAEGY	GO:0016757	transferase activity, transferring glycosyl groups	Gains
AAEGY	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
AAEGY	GO:0008301	DNA binding, bending	Gains
AAEGY	GO:0043565	sequence-specific DNA binding	Losses
AAEGY	GO:0003700	DNA binding transcription factor activity	Losses
AAEGY	GO:0140110	transcription regulator activity	Losses
AAEGY	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
AAEGY	GO:0003677	DNA binding	Losses
AAEGY	GO:0099600	transmembrane receptor activity	Losses
AAEGY	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
AAEGY	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
AAEGY	GO:0004871	signal transducer activity	Losses
AAEGY	GO:0003964	RNA-directed DNA polymerase activity	Losses
AAEGY	GO:0038023	signaling receptor activity	Losses
AAEGY	GO:0004888	transmembrane signaling receptor activity	Losses
AAEGY	GO:1990837	sequence-specific double-stranded DNA binding	Losses
AAEGY	GO:0005261	cation channel activity	Losses
AAEGY	GO:0022843	voltage-gated cation channel activity	Losses
AAEGY	GO:0005249	voltage-gated potassium channel activity	Losses
AAEGY	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
AAEGY	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
AAEGY	GO:0015079	potassium ion transmembrane transporter activity	Losses
AAEGY	GO:0001158	enhancer sequence-specific DNA binding	Losses
AAEGY	GO:0035326	enhancer binding	Losses
AAEGY	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
AAEGY	GO:0060089	molecular transducer activity	Losses
AAEGY	GO:0005267	potassium channel activity	Losses
AAEGY	GO:0008324	cation transmembrane transporter activity	Losses
AAEGY	GO:0034061	DNA polymerase activity	Losses
AAEGY	GO:0044212	transcription regulatory region DNA binding	Losses
AAEGY	GO:0019199	transmembrane receptor protein kinase activity	Losses
AAEGY	GO:0004872	receptor activity	Losses
AAEGY	GO:0001067	regulatory region nucleic acid binding	Losses
AAEGY	GO:0000975	regulatory region DNA binding	Losses
AAEGY	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
AAEGY	GO:0022836	gated channel activity	Losses
AAEGY	GO:0003690	double-stranded DNA binding	Losses
AAEGY	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
AAEGY	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
AAEGY	GO:0031490	chromatin DNA binding	Losses
AAEGY	GO:0005244	voltage-gated ion channel activity	Losses
AAEGY	GO:0022832	voltage-gated channel activity	Losses
AAEGY	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
AAEGY	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
AAEGY	GO:0046873	metal ion transmembrane transporter activity	Losses
AAEGY	GO:0022890	inorganic cation transmembrane transporter activity	Losses
AAEGY	GO:0004930	G-protein coupled receptor activity	Losses
AAEGY	GO:0004519	endonuclease activity	Losses
AAEGY	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
AAEGY	GO:0005227	calcium activated cation channel activity	Losses
AAEGY	GO:0030295	protein kinase activator activity	Losses
AAEGY	GO:0000339	RNA cap binding	Losses
AAEGY	GO:0019209	kinase activator activity	Losses
AAEGY	GO:0015085	calcium ion transmembrane transporter activity	Losses
AAEGY	GO:0004521	endoribonuclease activity	Losses
AAEGY	GO:0005509	calcium ion binding	Losses
AAEGY	GO:0005216	ion channel activity	Losses
AAEGY	GO:0022838	substrate-specific channel activity	Losses
AAEGY	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
AAEGY	GO:0005201	extracellular matrix structural constituent	Losses
AAEGY	GO:0004692	cGMP-dependent protein kinase activity	Losses
AAEGY	GO:0022839	ion gated channel activity	Losses
AAEGY	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
AAEGY	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AAEGY	GO:0003700	DNA binding transcription factor activity	Extinctions
AAEGY	GO:0003677	DNA binding	Extinctions
AAEGY	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
AAEGY	GO:0034061	DNA polymerase activity	Extinctions
AAEGY	GO:0043565	sequence-specific DNA binding	Extinctions
AAEGY	GO:0004519	endonuclease activity	Extinctions
AAEGY	GO:0005201	extracellular matrix structural constituent	Extinctions
AAEGY	GO:0140110	transcription regulator activity	Extinctions
AAEGY	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
AAEGY	GO:0004930	G-protein coupled receptor activity	Extinctions
AAEGY	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
AAEGY	GO:0016312	inositol bisphosphate phosphatase activity	Extinctions
AAEGY	GO:0033971	hydroxyisourate hydrolase activity	Extinctions
AAEGY	GO:0000268	peroxisome targeting sequence binding	Extinctions
AAEGY	GO:0047545	2-hydroxyglutarate dehydrogenase activity	Extinctions
AAEGY	GO:0005052	peroxisome matrix targeting signal-1 binding	Extinctions
AAEGY	GO:0005031	tumor necrosis factor-activated receptor activity	Extinctions
AAEGY	GO:0005035	death receptor activity	Extinctions
AAEGY	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
AAEGY	GO:0050564	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity	Extinctions
AAEGY	GO:0016933	extracellularly glycine-gated ion channel activity	Extinctions
AAEGY	GO:0005104	fibroblast growth factor receptor binding	Extinctions
AAEGY	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	Extinctions
AAEGY	GO:0008061	chitin binding	Extinctions
AAEGY	GO:0005198	structural molecule activity	Extinctions
AAEGY	GO:0003735	structural constituent of ribosome	Extinctions
AAEGY	GO:0099600	transmembrane receptor activity	Extinctions
AAEGY	GO:0016247	channel regulator activity	Extinctions
AAEGY	GO:0016917	GABA receptor activity	Extinctions
HSALT	GO:0003964	RNA-directed DNA polymerase activity	Gains
HSALT	GO:0034061	DNA polymerase activity	Gains
HSALT	GO:0140097	catalytic activity, acting on DNA	Gains
HSALT	GO:0016779	nucleotidyltransferase activity	Gains
HSALT	GO:0003676	nucleic acid binding	Gains
HSALT	GO:0005549	odorant binding	Gains
HSALT	GO:0004984	olfactory receptor activity	Gains
HSALT	GO:1901363	heterocyclic compound binding	Gains
HSALT	GO:0097159	organic cyclic compound binding	Gains
HSALT	GO:0004803	transposase activity	Gains
HSALT	GO:0003735	structural constituent of ribosome	Gains
HSALT	GO:0004518	nuclease activity	Gains
HSALT	GO:0003677	DNA binding	Gains
HSALT	GO:0005198	structural molecule activity	Gains
HSALT	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HSALT	GO:0005488	binding	Gains
HSALT	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HSALT	GO:0008233	peptidase activity	Gains
HSALT	GO:0003723	RNA binding	Gains
HSALT	GO:0019843	rRNA binding	Gains
HSALT	GO:0070001	aspartic-type peptidase activity	Gains
HSALT	GO:0004190	aspartic-type endopeptidase activity	Gains
HSALT	GO:0008270	zinc ion binding	Gains
HSALT	GO:0008453	alanine-glyoxylate transaminase activity	Gains
HSALT	GO:0046914	transition metal ion binding	Gains
HSALT	GO:0004175	endopeptidase activity	Gains
HSALT	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HSALT	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HSALT	GO:0004180	carboxypeptidase activity	Gains
HSALT	GO:0004252	serine-type endopeptidase activity	Gains
HSALT	GO:0004519	endonuclease activity	Gains
HSALT	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
HSALT	GO:0004521	endoribonuclease activity	Gains
HSALT	GO:0004497	monooxygenase activity	Gains
HSALT	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HSALT	GO:0008236	serine-type peptidase activity	Gains
HSALT	GO:0004736	pyruvate carboxylase activity	Gains
HSALT	GO:0017171	serine hydrolase activity	Gains
HSALT	GO:0004540	ribonuclease activity	Gains
HSALT	GO:0046872	metal ion binding	Losses
HSALT	GO:0003676	nucleic acid binding	Losses
HSALT	GO:0043169	cation binding	Losses
HSALT	GO:1901363	heterocyclic compound binding	Losses
HSALT	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
HSALT	GO:0097159	organic cyclic compound binding	Losses
HSALT	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
HSALT	GO:0043167	ion binding	Losses
HSALT	GO:0043565	sequence-specific DNA binding	Losses
HSALT	GO:0003677	DNA binding	Losses
HSALT	GO:0003700	DNA binding transcription factor activity	Losses
HSALT	GO:0140110	transcription regulator activity	Losses
HSALT	GO:0031490	chromatin DNA binding	Losses
HSALT	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
HSALT	GO:0044212	transcription regulatory region DNA binding	Losses
HSALT	GO:0001067	regulatory region nucleic acid binding	Losses
HSALT	GO:0000975	regulatory region DNA binding	Losses
HSALT	GO:0001158	enhancer sequence-specific DNA binding	Losses
HSALT	GO:0035326	enhancer binding	Losses
HSALT	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
HSALT	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
HSALT	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
HSALT	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
HSALT	GO:1990837	sequence-specific double-stranded DNA binding	Losses
HSALT	GO:0004692	cGMP-dependent protein kinase activity	Losses
HSALT	GO:0003746	translation elongation factor activity	Losses
HSALT	GO:0043035	chromatin insulator sequence binding	Losses
HSALT	GO:0042800	histone methyltransferase activity (H3-K4 specific)	Losses
HSALT	GO:0003690	double-stranded DNA binding	Losses
HSALT	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
HSALT	GO:0003777	microtubule motor activity	Losses
HSALT	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
HSALT	GO:0005249	voltage-gated potassium channel activity	Losses
HSALT	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
HSALT	GO:0005488	binding	Losses
HSALT	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
HSALT	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
HSALT	GO:0050797	thymidylate synthase (FAD) activity	Losses
HSALT	GO:0050897	cobalt ion binding	Losses
HSALT	GO:0001758	retinal dehydrogenase activity	Losses
HSALT	GO:0042979	ornithine decarboxylase regulator activity	Losses
HSALT	GO:0042925	benzoate transmembrane transporter activity	Losses
HSALT	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
HSALT	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
HSALT	GO:0005093	Rab GDP-dissociation inhibitor activity	Losses
HSALT	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
HSALT	GO:0036132	13-prostaglandin reductase activity	Losses
HSALT	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
HSALT	GO:0004060	arylamine N-acetyltransferase activity	Losses
HSALT	GO:0004054	arginine kinase activity	Losses
HSALT	GO:0004059	aralkylamine N-acetyltransferase activity	Losses
HSALT	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	Losses
HSALT	GO:0004038	allantoinase activity	Losses
HSALT	GO:0016794	diphosphoric monoester hydrolase activity	Losses
HSALT	GO:0004995	tachykinin receptor activity	Losses
HSALT	GO:0042767	ecdysteroid 22-hydroxylase activity	Losses
HSALT	GO:0043425	bHLH transcription factor binding	Losses
HSALT	GO:0005122	torso binding	Losses
HSALT	GO:0042586	peptide deformylase activity	Losses
HSALT	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
HSALT	GO:0005222	intracellular cAMP activated cation channel activity	Losses
HSALT	GO:0005223	intracellular cGMP activated cation channel activity	Losses
HSALT	GO:0008774	acetaldehyde dehydrogenase (acetylating) activity	Losses
HSALT	GO:0019182	histamine-gated chloride channel activity	Losses
HSALT	GO:0008728	GTP diphosphokinase activity	Losses
HSALT	GO:0071861	tachykinin receptor binding	Losses
HSALT	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Losses
HSALT	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
HSALT	GO:0008873	gluconate 2-dehydrogenase activity	Losses
HSALT	GO:0008875	gluconate dehydrogenase activity	Losses
HSALT	GO:0008810	cellulase activity	Losses
HSALT	GO:0018445	prothoracicotrophic hormone activity	Losses
HSALT	GO:0005326	neurotransmitter transporter activity	Losses
HSALT	GO:0003676	nucleic acid binding	Extinctions
HSALT	GO:0046872	metal ion binding	Extinctions
HSALT	GO:0043169	cation binding	Extinctions
HSALT	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Extinctions
HSALT	GO:0003677	DNA binding	Extinctions
HSALT	GO:1901363	heterocyclic compound binding	Extinctions
HSALT	GO:0097159	organic cyclic compound binding	Extinctions
HSALT	GO:0003700	DNA binding transcription factor activity	Extinctions
HSALT	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
HSALT	GO:0043565	sequence-specific DNA binding	Extinctions
HSALT	GO:0043167	ion binding	Extinctions
HSALT	GO:0140110	transcription regulator activity	Extinctions
HSALT	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
HSALT	GO:0044212	transcription regulatory region DNA binding	Extinctions
HSALT	GO:0001067	regulatory region nucleic acid binding	Extinctions
HSALT	GO:0000975	regulatory region DNA binding	Extinctions
HSALT	GO:0031490	chromatin DNA binding	Extinctions
HSALT	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Extinctions
HSALT	GO:0001012	RNA polymerase II regulatory region DNA binding	Extinctions
HSALT	GO:0043035	chromatin insulator sequence binding	Extinctions
HSALT	GO:0042800	histone methyltransferase activity (H3-K4 specific)	Extinctions
HSALT	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
HSALT	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
HSALT	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
HSALT	GO:0005326	neurotransmitter transporter activity	Extinctions
HSALT	GO:0003690	double-stranded DNA binding	Extinctions
HSALT	GO:0050797	thymidylate synthase (FAD) activity	Extinctions
HSALT	GO:0050897	cobalt ion binding	Extinctions
HSALT	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
HSALT	GO:0042925	benzoate transmembrane transporter activity	Extinctions
HSALT	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
HSALT	GO:0005093	Rab GDP-dissociation inhibitor activity	Extinctions
HSALT	GO:0036132	13-prostaglandin reductase activity	Extinctions
HSALT	GO:0004060	arylamine N-acetyltransferase activity	Extinctions
HSALT	GO:0004059	aralkylamine N-acetyltransferase activity	Extinctions
HSALT	GO:0004038	allantoinase activity	Extinctions
HSALT	GO:0016794	diphosphoric monoester hydrolase activity	Extinctions
HSALT	GO:0005122	torso binding	Extinctions
HSALT	GO:0042586	peptide deformylase activity	Extinctions
HSALT	GO:0008728	GTP diphosphokinase activity	Extinctions
HSALT	GO:0071861	tachykinin receptor binding	Extinctions
HSALT	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Extinctions
HSALT	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
HSALT	GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
HSALT	GO:0008875	gluconate dehydrogenase activity	Extinctions
HSALT	GO:0008810	cellulase activity	Extinctions
HSALT	GO:0018445	prothoracicotrophic hormone activity	Extinctions
HSALT	GO:0001158	enhancer sequence-specific DNA binding	Extinctions
HSALT	GO:0035326	enhancer binding	Extinctions
HSALT	GO:0003682	chromatin binding	Extinctions
DI23	GO:0004984	olfactory receptor activity	Gains
DI23	GO:0005549	odorant binding	Gains
DI23	GO:0003964	RNA-directed DNA polymerase activity	Gains
DI23	GO:0003677	DNA binding	Gains
DI23	GO:0004930	G-protein coupled receptor activity	Gains
DI23	GO:0038023	signaling receptor activity	Gains
DI23	GO:0008527	taste receptor activity	Gains
DI23	GO:0004888	transmembrane signaling receptor activity	Gains
DI23	GO:0004190	aspartic-type endopeptidase activity	Gains
DI23	GO:0070001	aspartic-type peptidase activity	Gains
DI23	GO:0003676	nucleic acid binding	Gains
DI23	GO:0034061	DNA polymerase activity	Gains
DI23	GO:0099600	transmembrane receptor activity	Gains
DI23	GO:0004803	transposase activity	Gains
DI23	GO:0004871	signal transducer activity	Gains
DI23	GO:0140097	catalytic activity, acting on DNA	Gains
DI23	GO:0060089	molecular transducer activity	Gains
DI23	GO:0004872	receptor activity	Gains
DI23	GO:0048019	receptor antagonist activity	Gains
DI23	GO:0030547	receptor inhibitor activity	Gains
DI23	GO:0003680	AT DNA binding	Gains
DI23	GO:0004736	pyruvate carboxylase activity	Gains
DI23	GO:0005249	voltage-gated potassium channel activity	Gains
DI23	GO:0000155	phosphorelay sensor kinase activity	Gains
DI23	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DI23	GO:0004673	protein histidine kinase activity	Gains
DI23	GO:0016779	nucleotidyltransferase activity	Gains
DI23	GO:0004075	biotin carboxylase activity	Gains
DI23	GO:0048038	quinone binding	Gains
DI23	GO:0005154	epidermal growth factor receptor binding	Gains
DI23	GO:0043015	gamma-tubulin binding	Gains
DI23	GO:1990837	sequence-specific double-stranded DNA binding	Gains
DI23	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
DI23	GO:0061135	endopeptidase regulator activity	Gains
DI23	GO:0042802	identical protein binding	Gains
DI23	GO:0003690	double-stranded DNA binding	Gains
DI23	GO:0045182	translation regulator activity	Gains
DI23	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Gains
DI23	GO:0019201	nucleotide kinase activity	Gains
DI23	GO:0005267	potassium channel activity	Gains
DI23	GO:0015035	protein disulfide oxidoreductase activity	Gains
DI23	GO:0004089	carbonate dehydratase activity	Gains
DI23	GO:0001098	basal transcription machinery binding	Gains
DI23	GO:0001099	basal RNA polymerase II transcription machinery binding	Gains
DI23	GO:0016755	transferase activity, transferring amino-acyl groups	Gains
DI23	GO:0004385	guanylate kinase activity	Gains
DI23	GO:0070851	growth factor receptor binding	Gains
DI23	GO:0004519	endonuclease activity	Gains
DI23	GO:0005244	voltage-gated ion channel activity	Gains
DI23	GO:0022832	voltage-gated channel activity	Gains
DI23	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
DI23	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
DI23	GO:0015002	heme-copper terminal oxidase activity	Gains
DI23	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
DI23	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
DI23	GO:0004129	cytochrome-c oxidase activity	Gains
DI23	GO:0004175	endopeptidase activity	Gains
DI23	GO:1901363	heterocyclic compound binding	Gains
DI23	GO:0004872	receptor activity	Losses
DI23	GO:0060089	molecular transducer activity	Losses
DI23	GO:0099600	transmembrane receptor activity	Losses
DI23	GO:0008061	chitin binding	Losses
DI23	GO:0016801	hydrolase activity, acting on ether bonds	Losses
DI23	GO:0004888	transmembrane signaling receptor activity	Losses
DI23	GO:0038023	signaling receptor activity	Losses
DI23	GO:0005549	odorant binding	Losses
DI23	GO:0016803	ether hydrolase activity	Losses
DI23	GO:0004930	G-protein coupled receptor activity	Losses
DI23	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
DI23	GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
DI23	GO:0008236	serine-type peptidase activity	Losses
DI23	GO:0004252	serine-type endopeptidase activity	Losses
DI23	GO:0017171	serine hydrolase activity	Losses
DI23	GO:0005501	retinoid binding	Losses
DI23	GO:0099094	ligand-gated cation channel activity	Losses
DI23	GO:0004871	signal transducer activity	Losses
DI23	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
DI23	GO:0019840	isoprenoid binding	Losses
DI23	GO:0032450	maltose alpha-glucosidase activity	Losses
DI23	GO:0003990	acetylcholinesterase activity	Losses
DI23	GO:0090599	alpha-glucosidase activity	Losses
DI23	GO:0008233	peptidase activity	Losses
DI23	GO:0004497	monooxygenase activity	Losses
DI23	GO:0022834	ligand-gated channel activity	Losses
DI23	GO:0015276	ligand-gated ion channel activity	Losses
DI23	GO:0004027	alcohol sulfotransferase activity	Losses
DI23	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
DI23	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
DI23	GO:0004946	bombesin receptor activity	Losses
DI23	GO:0008477	purine nucleosidase activity	Losses
DI23	GO:0008160	protein tyrosine phosphatase activator activity	Losses
DI23	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
DI23	GO:0004371	glycerone kinase activity	Losses
DI23	GO:0004321	fatty-acyl-CoA synthase activity	Losses
DI23	GO:0004304	estrone sulfotransferase activity	Losses
DI23	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Losses
DI23	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
DI23	GO:0051721	protein phosphatase 2A binding	Losses
DI23	GO:0004167	dopachrome isomerase activity	Losses
DI23	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
DI23	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
DI23	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
DI23	GO:0008836	diaminopimelate decarboxylase activity	Losses
DI23	GO:0004100	chitin synthase activity	Losses
DI23	GO:0019211	phosphatase activator activity	Losses
DI23	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
DI23	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
DI23	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
DI23	GO:0016918	retinal binding	Losses
DI23	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
DI23	GO:0042947	glucoside transmembrane transporter activity	Losses
DI23	GO:0015280	ligand-gated sodium channel activity	Losses
DI23	GO:0004556	alpha-amylase activity	Losses
DI23	GO:0004586	ornithine decarboxylase activity	Losses
DI23	GO:0072542	protein phosphatase activator activity	Losses
DI23	GO:0004517	nitric-oxide synthase activity	Losses
DI23	GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity	Losses
DI23	GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	Losses
DI23	GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity	Losses
DI23	GO:0003973	(S)-2-hydroxy-acid oxidase activity	Losses
DI23	GO:0044736	acid-sensing ion channel activity	Losses
DI23	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
DI23	GO:0016499	orexin receptor activity	Losses
DI23	GO:0036132	13-prostaglandin reductase activity	Losses
DI23	GO:0016160	amylase activity	Losses
DI23	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
DI23	GO:0015574	trehalose transmembrane transporter activity	Losses
DI23	GO:0004062	aryl sulfotransferase activity	Losses
DI23	GO:0030247	polysaccharide binding	Losses
DI23	GO:0004104	cholinesterase activity	Losses
DI23	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
DI23	GO:0042910	xenobiotic transmembrane transporter activity	Losses
DI23	GO:0001871	pattern binding	Losses
DI23	GO:0004175	endopeptidase activity	Losses
DI23	GO:0015926	glucosidase activity	Losses
DI23	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DI23	GO:0010181	FMN binding	Losses
DI23	GO:0005549	odorant binding	Extinctions
DI23	GO:0008061	chitin binding	Extinctions
DI23	GO:0004930	G-protein coupled receptor activity	Extinctions
DI23	GO:0099600	transmembrane receptor activity	Extinctions
DI23	GO:0008236	serine-type peptidase activity	Extinctions
DI23	GO:0017171	serine hydrolase activity	Extinctions
DI23	GO:0004252	serine-type endopeptidase activity	Extinctions
DI23	GO:0004888	transmembrane signaling receptor activity	Extinctions
DI23	GO:0004872	receptor activity	Extinctions
DI23	GO:0008477	purine nucleosidase activity	Extinctions
DI23	GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
DI23	GO:0004371	glycerone kinase activity	Extinctions
DI23	GO:0051721	protein phosphatase 2A binding	Extinctions
DI23	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
DI23	GO:0019211	phosphatase activator activity	Extinctions
DI23	GO:0072542	protein phosphatase activator activity	Extinctions
DI23	GO:0036132	13-prostaglandin reductase activity	Extinctions
DI23	GO:0060089	molecular transducer activity	Extinctions
DI23	GO:0038023	signaling receptor activity	Extinctions
DI23	GO:0016084	myostimulatory hormone activity	Extinctions
DI23	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Extinctions
DI21	GO:0004175	endopeptidase activity	Gains
DI21	GO:0004252	serine-type endopeptidase activity	Gains
DI21	GO:0008236	serine-type peptidase activity	Gains
DI21	GO:0017171	serine hydrolase activity	Gains
DI21	GO:0008527	taste receptor activity	Gains
DI21	GO:0008061	chitin binding	Gains
DI21	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI21	GO:0008233	peptidase activity	Gains
DI21	GO:0005549	odorant binding	Gains
DI21	GO:0099600	transmembrane receptor activity	Gains
DI21	GO:0004872	receptor activity	Gains
DI21	GO:0004888	transmembrane signaling receptor activity	Gains
DI21	GO:0060089	molecular transducer activity	Gains
DI21	GO:0004984	olfactory receptor activity	Gains
DI21	GO:0038023	signaling receptor activity	Gains
DI21	GO:0030246	carbohydrate binding	Gains
DI21	GO:0004298	threonine-type endopeptidase activity	Gains
DI21	GO:0070003	threonine-type peptidase activity	Gains
DI21	GO:0008556	potassium-transporting ATPase activity	Gains
DI21	GO:0016615	malate dehydrogenase activity	Gains
DI21	GO:0022857	transmembrane transporter activity	Gains
DI21	GO:0015276	ligand-gated ion channel activity	Gains
DI21	GO:0022834	ligand-gated channel activity	Gains
DI21	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Gains
DI21	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Gains
DI21	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Gains
DI21	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
DI21	GO:0004930	G-protein coupled receptor activity	Gains
DI21	GO:0031418	L-ascorbic acid binding	Gains
DI21	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
DI21	GO:0004470	malic enzyme activity	Gains
DI21	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
DI21	GO:0031543	peptidyl-proline dioxygenase activity	Gains
DI21	GO:0005125	cytokine activity	Gains
DI21	GO:0004568	chitinase activity	Gains
DI21	GO:0048029	monosaccharide binding	Gains
DI21	GO:0004190	aspartic-type endopeptidase activity	Gains
DI21	GO:0070001	aspartic-type peptidase activity	Gains
DI21	GO:0008566	mitochondrial protein-transporting ATPase activity	Gains
DI21	GO:0015462	ATPase-coupled protein transmembrane transporter activity	Gains
DI21	GO:0038187	pattern recognition receptor activity	Gains
DI21	GO:0008329	signaling pattern recognition receptor activity	Gains
DI21	GO:0003998	acylphosphatase activity	Gains
DI21	GO:0008900	hydrogen:potassium-exchanging ATPase activity	Gains
DI21	GO:0033883	pyridoxal phosphatase activity	Gains
DI21	GO:0004046	aminoacylase activity	Gains
DI21	GO:0004871	signal transducer activity	Gains
DI21	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DI21	GO:0019798	procollagen-proline dioxygenase activity	Gains
DI21	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DI21	GO:1904680	peptide transmembrane transporter activity	Gains
DI21	GO:0042887	amide transmembrane transporter activity	Gains
DI21	GO:0022891	substrate-specific transmembrane transporter activity	Gains
DI21	GO:0004971	AMPA glutamate receptor activity	Gains
DI21	GO:0004180	carboxypeptidase activity	Gains
DI21	GO:0016881	acid-amino acid ligase activity	Gains
DI21	GO:0009055	electron transfer activity	Gains
DI21	GO:0004463	leukotriene-A4 hydrolase activity	Gains
DI21	GO:0033041	sweet taste receptor activity	Gains
DI21	GO:0045735	nutrient reservoir activity	Gains
DI21	GO:0031386	protein tag	Gains
DI21	GO:0004035	alkaline phosphatase activity	Gains
DI21	GO:0048018	receptor ligand activity	Gains
DI21	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
DI21	GO:0005215	transporter activity	Gains
DI21	GO:0043177	organic acid binding	Gains
DI21	GO:0031406	carboxylic acid binding	Gains
DI21	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DI21	GO:0019208	phosphatase regulator activity	Gains
DI21	GO:0051287	NAD binding	Gains
DI21	GO:0019903	protein phosphatase binding	Gains
DI21	GO:0030545	receptor regulator activity	Gains
DI21	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
DI21	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI21	GO:0005267	potassium channel activity	Losses
DI21	GO:0003676	nucleic acid binding	Losses
DI21	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DI21	GO:0005249	voltage-gated potassium channel activity	Losses
DI21	GO:0015079	potassium ion transmembrane transporter activity	Losses
DI21	GO:0043167	ion binding	Losses
DI21	GO:0005244	voltage-gated ion channel activity	Losses
DI21	GO:0022832	voltage-gated channel activity	Losses
DI21	GO:0004803	transposase activity	Losses
DI21	GO:0034061	DNA polymerase activity	Losses
DI21	GO:0140097	catalytic activity, acting on DNA	Losses
DI21	GO:0022843	voltage-gated cation channel activity	Losses
DI21	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
DI21	GO:1901363	heterocyclic compound binding	Losses
DI21	GO:0097159	organic cyclic compound binding	Losses
DI21	GO:0008270	zinc ion binding	Losses
DI21	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
DI21	GO:0046914	transition metal ion binding	Losses
DI21	GO:0004222	metalloendopeptidase activity	Losses
DI21	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
DI21	GO:0004521	endoribonuclease activity	Losses
DI21	GO:0004540	ribonuclease activity	Losses
DI21	GO:0046872	metal ion binding	Losses
DI21	GO:0005488	binding	Losses
DI21	GO:0043169	cation binding	Losses
DI21	GO:0022836	gated channel activity	Losses
DI21	GO:0030554	adenyl nucleotide binding	Losses
DI21	GO:0003677	DNA binding	Losses
DI21	GO:0015269	calcium-activated potassium channel activity	Losses
DI21	GO:0004175	endopeptidase activity	Losses
DI21	GO:0005524	ATP binding	Losses
DI21	GO:0016779	nucleotidyltransferase activity	Losses
DI21	GO:0032559	adenyl ribonucleotide binding	Losses
DI21	GO:0005227	calcium activated cation channel activity	Losses
DI21	GO:0004386	helicase activity	Losses
DI21	GO:0060089	molecular transducer activity	Losses
DI21	GO:0016301	kinase activity	Losses
DI21	GO:0004190	aspartic-type endopeptidase activity	Losses
DI21	GO:0070001	aspartic-type peptidase activity	Losses
DI21	GO:0005201	extracellular matrix structural constituent	Losses
DI21	GO:0004872	receptor activity	Losses
DI21	GO:0004385	guanylate kinase activity	Losses
DI21	GO:0022839	ion gated channel activity	Losses
DI21	GO:0140098	catalytic activity, acting on RNA	Losses
DI21	GO:0038023	signaling receptor activity	Losses
DI21	GO:0050254	rhodopsin kinase activity	Losses
DI21	GO:0004871	signal transducer activity	Losses
DI21	GO:0004692	cGMP-dependent protein kinase activity	Losses
DI21	GO:1902936	phosphatidylinositol bisphosphate binding	Losses
DI21	GO:0005507	copper ion binding	Losses
DI21	GO:0008233	peptidase activity	Losses
DI21	GO:0005261	cation channel activity	Losses
DI21	GO:0016787	hydrolase activity	Losses
DI21	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
DI21	GO:0008289	lipid binding	Losses
DI21	GO:0017076	purine nucleotide binding	Losses
DI21	GO:0003723	RNA binding	Losses
DI21	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DI21	GO:0004518	nuclease activity	Losses
DI21	GO:0005216	ion channel activity	Losses
DI21	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	Losses
DI21	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
DI21	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
DI21	GO:0047200	tetrahydrodipicolinate N-acetyltransferase activity	Losses
DI21	GO:0008747	N-acetylneuraminate lyase activity	Losses
DI21	GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	Losses
DI21	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Losses
DI21	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Losses
DI21	GO:0042954	lipoprotein transporter activity	Losses
DI21	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Losses
DI21	GO:0008974	phosphoribulokinase activity	Losses
DI21	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Losses
DI21	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Losses
DI21	GO:0022838	substrate-specific channel activity	Losses
DI21	GO:0030247	polysaccharide binding	Losses
DI21	GO:0001871	pattern binding	Losses
DI21	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
DI21	GO:0097367	carbohydrate derivative binding	Losses
DI21	GO:0015267	channel activity	Losses
DI21	GO:0022803	passive transmembrane transporter activity	Losses
DI21	GO:0032555	purine ribonucleotide binding	Losses
DI21	GO:0016881	acid-amino acid ligase activity	Losses
DI21	GO:0004519	endonuclease activity	Losses
DI21	GO:0032553	ribonucleotide binding	Losses
DI21	GO:0008237	metallopeptidase activity	Losses
DI21	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
DI21	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
DI21	GO:0035639	purine ribonucleoside triphosphate binding	Losses
DI21	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
DI21	GO:0019201	nucleotide kinase activity	Losses
DI21	GO:0046872	metal ion binding	Extinctions
DI21	GO:0043169	cation binding	Extinctions
DI21	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI21	GO:0043167	ion binding	Extinctions
DI21	GO:0046914	transition metal ion binding	Extinctions
DI21	GO:0003676	nucleic acid binding	Extinctions
DI21	GO:0034061	DNA polymerase activity	Extinctions
DI21	GO:0008233	peptidase activity	Extinctions
DI21	GO:0008270	zinc ion binding	Extinctions
DI21	GO:0005507	copper ion binding	Extinctions
DI21	GO:0004222	metalloendopeptidase activity	Extinctions
DI21	GO:0140097	catalytic activity, acting on DNA	Extinctions
DI21	GO:0004175	endopeptidase activity	Extinctions
DI21	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
DI21	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
DI21	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
DI21	GO:0004540	ribonuclease activity	Extinctions
DI21	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
DI21	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
DI21	GO:0047200	tetrahydrodipicolinate N-acetyltransferase activity	Extinctions
DI21	GO:0008747	N-acetylneuraminate lyase activity	Extinctions
DI21	GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	Extinctions
DI21	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Extinctions
DI21	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
DI21	GO:0042954	lipoprotein transporter activity	Extinctions
DI21	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Extinctions
DI21	GO:0008974	phosphoribulokinase activity	Extinctions
DI21	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Extinctions
DI21	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
DI21	GO:0004190	aspartic-type endopeptidase activity	Extinctions
DI21	GO:0070001	aspartic-type peptidase activity	Extinctions
DI21	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
DI21	GO:0003954	NADH dehydrogenase activity	Extinctions
DI21	GO:0004518	nuclease activity	Extinctions
DI21	GO:0004521	endoribonuclease activity	Extinctions
DI21	GO:0004022	alcohol dehydrogenase (NAD) activity	Extinctions
DI21	GO:0034235	GPI anchor binding	Extinctions
DI21	GO:0016833	oxo-acid-lyase activity	Extinctions
DI21	GO:0015054	gastrin receptor activity	Extinctions
DI21	GO:0004335	galactokinase activity	Extinctions
DI21	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Extinctions
DI21	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
DI21	GO:0005201	extracellular matrix structural constituent	Extinctions
DI21	GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
DI21	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
DI21	GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
DI21	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	Extinctions
DI21	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
DI21	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
DI21	GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
DI21	GO:0004504	peptidylglycine monooxygenase activity	Extinctions
DI21	GO:0003939	L-iditol 2-dehydrogenase activity	Extinctions
DI21	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
DI21	GO:0008237	metallopeptidase activity	Extinctions
LDECE	GO:0003964	RNA-directed DNA polymerase activity	Gains
LDECE	GO:0140097	catalytic activity, acting on DNA	Gains
LDECE	GO:0034061	DNA polymerase activity	Gains
LDECE	GO:0003676	nucleic acid binding	Gains
LDECE	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
LDECE	GO:0016779	nucleotidyltransferase activity	Gains
LDECE	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
LDECE	GO:0070001	aspartic-type peptidase activity	Gains
LDECE	GO:0004190	aspartic-type endopeptidase activity	Gains
LDECE	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
LDECE	GO:0004518	nuclease activity	Gains
LDECE	GO:0004521	endoribonuclease activity	Gains
LDECE	GO:1901363	heterocyclic compound binding	Gains
LDECE	GO:0097159	organic cyclic compound binding	Gains
LDECE	GO:0004519	endonuclease activity	Gains
LDECE	GO:0004064	arylesterase activity	Gains
LDECE	GO:0046914	transition metal ion binding	Gains
LDECE	GO:0008270	zinc ion binding	Gains
LDECE	GO:0004540	ribonuclease activity	Gains
LDECE	GO:0004965	G-protein coupled GABA receptor activity	Gains
LDECE	GO:0004447	iodide peroxidase activity	Gains
LDECE	GO:0005549	odorant binding	Gains
LDECE	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
LDECE	GO:0005201	extracellular matrix structural constituent	Gains
LDECE	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
LDECE	GO:0005216	ion channel activity	Gains
LDECE	GO:0005488	binding	Gains
LDECE	GO:0022838	substrate-specific channel activity	Gains
LDECE	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
LDECE	GO:0016917	GABA receptor activity	Gains
LDECE	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
LDECE	GO:0046873	metal ion transmembrane transporter activity	Gains
LDECE	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
LDECE	GO:0022803	passive transmembrane transporter activity	Gains
LDECE	GO:0015267	channel activity	Gains
LDECE	GO:0015036	disulfide oxidoreductase activity	Gains
LDECE	GO:0015081	sodium ion transmembrane transporter activity	Gains
LDECE	GO:0003723	RNA binding	Gains
LDECE	GO:0019955	cytokine binding	Gains
LDECE	GO:0004035	alkaline phosphatase activity	Gains
LDECE	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
LDECE	GO:0030151	molybdenum ion binding	Gains
LDECE	GO:0005328	neurotransmitter:sodium symporter activity	Gains
LDECE	GO:0005261	cation channel activity	Gains
LDECE	GO:0061134	peptidase regulator activity	Gains
LDECE	GO:0061135	endopeptidase regulator activity	Gains
LDECE	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
LDECE	GO:0015294	solute:cation symporter activity	Gains
LDECE	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
LDECE	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
LDECE	GO:0004971	AMPA glutamate receptor activity	Gains
LDECE	GO:0008332	low voltage-gated calcium channel activity	Gains
LDECE	GO:0015095	magnesium ion transmembrane transporter activity	Gains
LDECE	GO:0043546	molybdopterin cofactor binding	Gains
LDECE	GO:0008198	ferrous iron binding	Gains
LDECE	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
LDECE	GO:0004427	inorganic diphosphatase activity	Gains
LDECE	GO:0015154	disaccharide transmembrane transporter activity	Gains
LDECE	GO:0015157	oligosaccharide transmembrane transporter activity	Gains
LDECE	GO:0004820	glycine-tRNA ligase activity	Gains
LDECE	GO:0015370	solute:sodium symporter activity	Gains
LDECE	GO:0099600	transmembrane receptor activity	Losses
LDECE	GO:0038023	signaling receptor activity	Losses
LDECE	GO:0004872	receptor activity	Losses
LDECE	GO:0004888	transmembrane signaling receptor activity	Losses
LDECE	GO:0004871	signal transducer activity	Losses
LDECE	GO:0060089	molecular transducer activity	Losses
LDECE	GO:0004930	G-protein coupled receptor activity	Losses
LDECE	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
LDECE	GO:0008324	cation transmembrane transporter activity	Losses
LDECE	GO:0022890	inorganic cation transmembrane transporter activity	Losses
LDECE	GO:0015075	ion transmembrane transporter activity	Losses
LDECE	GO:0022857	transmembrane transporter activity	Losses
LDECE	GO:0019199	transmembrane receptor protein kinase activity	Losses
LDECE	GO:0022891	substrate-specific transmembrane transporter activity	Losses
LDECE	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
LDECE	GO:0015002	heme-copper terminal oxidase activity	Losses
LDECE	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
LDECE	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
LDECE	GO:0004129	cytochrome-c oxidase activity	Losses
LDECE	GO:0008528	G-protein coupled peptide receptor activity	Losses
LDECE	GO:0001653	peptide receptor activity	Losses
LDECE	GO:0005242	inward rectifier potassium channel activity	Losses
LDECE	GO:0022892	substrate-specific transporter activity	Losses
LDECE	GO:0008238	exopeptidase activity	Losses
LDECE	GO:0004713	protein tyrosine kinase activity	Losses
LDECE	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
LDECE	GO:0009055	electron transfer activity	Losses
LDECE	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
LDECE	GO:0005215	transporter activity	Losses
LDECE	GO:0004180	carboxypeptidase activity	Losses
LDECE	GO:0030234	enzyme regulator activity	Losses
LDECE	GO:0061134	peptidase regulator activity	Losses
LDECE	GO:0008484	sulfuric ester hydrolase activity	Losses
LDECE	GO:0015116	sulfate transmembrane transporter activity	Losses
LDECE	GO:0004672	protein kinase activity	Losses
LDECE	GO:0030414	peptidase inhibitor activity	Losses
LDECE	GO:0008047	enzyme activator activity	Losses
LDECE	GO:0098772	molecular function regulator	Losses
LDECE	GO:0008188	neuropeptide receptor activity	Losses
LDECE	GO:0016917	GABA receptor activity	Losses
LDECE	GO:0022804	active transmembrane transporter activity	Losses
LDECE	GO:0015291	secondary active transmembrane transporter activity	Losses
LDECE	GO:0016301	kinase activity	Losses
LDECE	GO:0046873	metal ion transmembrane transporter activity	Losses
LDECE	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
LDECE	GO:0005261	cation channel activity	Losses
LDECE	GO:0004849	uridine kinase activity	Losses
LDECE	GO:0016215	acyl-CoA desaturase activity	Losses
LDECE	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
LDECE	GO:0030296	protein tyrosine kinase activator activity	Losses
LDECE	GO:0004768	stearoyl-CoA 9-desaturase activity	Losses
LDECE	GO:0004784	superoxide dismutase activity	Losses
LDECE	GO:0001786	phosphatidylserine binding	Losses
LDECE	GO:0004857	enzyme inhibitor activity	Losses
LDECE	GO:0009881	photoreceptor activity	Losses
LDECE	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
LDECE	GO:0016209	antioxidant activity	Losses
LDECE	GO:0022803	passive transmembrane transporter activity	Losses
LDECE	GO:0015267	channel activity	Losses
LDECE	GO:0005267	potassium channel activity	Losses
LDECE	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
LDECE	GO:0004952	dopamine neurotransmitter receptor activity	Losses
LDECE	GO:0016500	protein-hormone receptor activity	Losses
LDECE	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Losses
LDECE	GO:0008241	peptidyl-dipeptidase activity	Losses
LDECE	GO:0003700	DNA binding transcription factor activity	Losses
LDECE	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
LDECE	GO:0008235	metalloexopeptidase activity	Losses
LDECE	GO:0004866	endopeptidase inhibitor activity	Losses
LDECE	GO:0005216	ion channel activity	Losses
LDECE	GO:0022838	substrate-specific channel activity	Losses
LDECE	GO:0008237	metallopeptidase activity	Losses
LDECE	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Losses
LDECE	GO:0005024	transforming growth factor beta-activated receptor activity	Losses
LDECE	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
LDECE	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
LDECE	GO:0072341	modified amino acid binding	Losses
LDECE	GO:0019209	kinase activator activity	Losses
LDECE	GO:0030295	protein kinase activator activity	Losses
LDECE	GO:0099094	ligand-gated cation channel activity	Losses
LDECE	GO:0008484	sulfuric ester hydrolase activity	Extinctions
LDECE	GO:0004930	G-protein coupled receptor activity	Extinctions
LDECE	GO:0005242	inward rectifier potassium channel activity	Extinctions
LDECE	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Extinctions
LDECE	GO:0005024	transforming growth factor beta-activated receptor activity	Extinctions
LDECE	GO:0030545	receptor regulator activity	Extinctions
LDECE	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
LDECE	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
LDECE	GO:1902936	phosphatidylinositol bisphosphate binding	Extinctions
LDECE	GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
LDECE	GO:0051721	protein phosphatase 2A binding	Extinctions
LDECE	GO:0050262	ribosylnicotinamide kinase activity	Extinctions
LDECE	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Extinctions
LDECE	GO:0072542	protein phosphatase activator activity	Extinctions
LDECE	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
LDECE	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
LDECE	GO:0032542	sulfiredoxin activity	Extinctions
LDECE	GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Extinctions
LDECE	GO:0052856	NADHX epimerase activity	Extinctions
LDECE	GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
LDECE	GO:0004423	iduronate-2-sulfatase activity	Extinctions
LDECE	GO:0034235	GPI anchor binding	Extinctions
LDECE	GO:0005213	structural constituent of chorion	Extinctions
LDECE	GO:0019211	phosphatase activator activity	Extinctions
LDECE	GO:0016034	maleylacetoacetate isomerase activity	Extinctions
LDECE	GO:0008881	glutamate racemase activity	Extinctions
LDECE	GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
LDECE	GO:0008875	gluconate dehydrogenase activity	Extinctions
LDECE	GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
LDECE	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
LDECE	GO:0008816	citryl-CoA lyase activity	Extinctions
LDECE	GO:0018271	biotin-protein ligase activity	Extinctions
LDECE	GO:0099600	transmembrane receptor activity	Extinctions
LDECE	GO:0098772	molecular function regulator	Extinctions
AFLOR	GO:0003700	DNA binding transcription factor activity	Gains
AFLOR	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
AFLOR	GO:0005549	odorant binding	Gains
AFLOR	GO:0015144	carbohydrate transmembrane transporter activity	Gains
AFLOR	GO:0032050	clathrin heavy chain binding	Gains
AFLOR	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
AFLOR	GO:0140110	transcription regulator activity	Gains
AFLOR	GO:0015291	secondary active transmembrane transporter activity	Gains
AFLOR	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
AFLOR	GO:0030276	clathrin binding	Gains
AFLOR	GO:0015293	symporter activity	Gains
AFLOR	GO:0051119	sugar transmembrane transporter activity	Gains
AFLOR	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
AFLOR	GO:0003993	acid phosphatase activity	Gains
AFLOR	GO:0004984	olfactory receptor activity	Gains
AFLOR	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Gains
AFLOR	GO:0015294	solute:cation symporter activity	Gains
AFLOR	GO:0008509	anion transmembrane transporter activity	Gains
AFLOR	GO:0019104	DNA N-glycosylase activity	Gains
AFLOR	GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
AFLOR	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
AFLOR	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
AFLOR	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
AFLOR	GO:0008484	sulfuric ester hydrolase activity	Gains
AFLOR	GO:0005351	sugar:proton symporter activity	Gains
AFLOR	GO:0005402	cation:sugar symporter activity	Gains
AFLOR	GO:0015295	solute:proton symporter activity	Gains
AFLOR	GO:0000155	phosphorelay sensor kinase activity	Gains
AFLOR	GO:0004673	protein histidine kinase activity	Gains
AFLOR	GO:0005342	organic acid transmembrane transporter activity	Gains
AFLOR	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
AFLOR	GO:0042302	structural constituent of cuticle	Gains
AFLOR	GO:0052657	guanine phosphoribosyltransferase activity	Gains
AFLOR	GO:0004053	arginase activity	Gains
AFLOR	GO:0070976	TIR domain binding	Gains
AFLOR	GO:0046570	methylthioribulose 1-phosphate dehydratase activity	Gains
AFLOR	GO:0047134	protein-disulfide reductase activity	Gains
AFLOR	GO:0008490	arsenite secondary active transmembrane transporter activity	Gains
AFLOR	GO:0008473	ornithine cyclodeaminase activity	Gains
AFLOR	GO:0015026	coreceptor activity	Gains
AFLOR	GO:0017151	DEAD/H-box RNA helicase binding	Gains
AFLOR	GO:0097506	deaminated base DNA N-glycosylase activity	Gains
AFLOR	GO:0042879	aldonate transmembrane transporter activity	Gains
AFLOR	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Gains
AFLOR	GO:0000990	transcription factor activity, core RNA polymerase binding	Gains
AFLOR	GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity	Gains
AFLOR	GO:0004422	hypoxanthine phosphoribosyltransferase activity	Gains
AFLOR	GO:0004417	hydroxyethylthiazole kinase activity	Gains
AFLOR	GO:0004145	diamine N-acetyltransferase activity	Gains
AFLOR	GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
AFLOR	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Gains
AFLOR	GO:0004133	glycogen debranching enzyme activity	Gains
AFLOR	GO:0004134	4-alpha-glucanotransferase activity	Gains
AFLOR	GO:0004135	amylo-alpha-1,6-glucosidase activity	Gains
AFLOR	GO:0008836	diaminopimelate decarboxylase activity	Gains
AFLOR	GO:0015446	ATPase-coupled arsenite transmembrane transporter activity	Gains
AFLOR	GO:0016987	sigma factor activity	Gains
AFLOR	GO:0008579	JUN kinase phosphatase activity	Gains
AFLOR	GO:0008515	sucrose transmembrane transporter activity	Gains
AFLOR	GO:0016933	extracellularly glycine-gated ion channel activity	Gains
AFLOR	GO:0015128	gluconate transmembrane transporter activity	Gains
AFLOR	GO:0015142	tricarboxylic acid transmembrane transporter activity	Gains
AFLOR	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Gains
AFLOR	GO:0015137	citrate transmembrane transporter activity	Gains
AFLOR	GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	Gains
AFLOR	GO:0015105	arsenite transmembrane transporter activity	Gains
AFLOR	GO:0009032	thymidine phosphorylase activity	Gains
AFLOR	GO:0004844	uracil DNA N-glycosylase activity	Gains
AFLOR	GO:0004586	ornithine decarboxylase activity	Gains
AFLOR	GO:0003935	GTP cyclohydrolase II activity	Gains
AFLOR	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Gains
AFLOR	GO:0008972	phosphomethylpyrimidine kinase activity	Gains
AFLOR	GO:0016154	pyrimidine-nucleoside phosphorylase activity	Gains
AFLOR	GO:0005003	ephrin receptor activity	Gains
AFLOR	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
AFLOR	GO:0008374	O-acyltransferase activity	Gains
AFLOR	GO:0003964	RNA-directed DNA polymerase activity	Losses
AFLOR	GO:0005214	structural constituent of chitin-based cuticle	Losses
AFLOR	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
AFLOR	GO:0034061	DNA polymerase activity	Losses
AFLOR	GO:0042302	structural constituent of cuticle	Losses
AFLOR	GO:0018685	alkane 1-monooxygenase activity	Losses
AFLOR	GO:0070001	aspartic-type peptidase activity	Losses
AFLOR	GO:0004190	aspartic-type endopeptidase activity	Losses
AFLOR	GO:0005198	structural molecule activity	Losses
AFLOR	GO:0015926	glucosidase activity	Losses
AFLOR	GO:0140097	catalytic activity, acting on DNA	Losses
AFLOR	GO:0003909	DNA ligase activity	Losses
AFLOR	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
AFLOR	GO:0020037	heme binding	Losses
AFLOR	GO:0046906	tetrapyrrole binding	Losses
AFLOR	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
AFLOR	GO:0008241	peptidyl-dipeptidase activity	Losses
AFLOR	GO:0019238	cyclohydrolase activity	Losses
AFLOR	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
AFLOR	GO:0005201	extracellular matrix structural constituent	Losses
AFLOR	GO:0008227	G-protein coupled amine receptor activity	Losses
AFLOR	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
AFLOR	GO:0004993	G-protein coupled serotonin receptor activity	Losses
AFLOR	GO:0070330	aromatase activity	Losses
AFLOR	GO:0099589	serotonin receptor activity	Losses
AFLOR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
AFLOR	GO:0032450	maltose alpha-glucosidase activity	Losses
AFLOR	GO:0099600	transmembrane receptor activity	Losses
AFLOR	GO:0004930	G-protein coupled receptor activity	Losses
AFLOR	GO:0016491	oxidoreductase activity	Losses
AFLOR	GO:0090079	translation regulator activity, nucleic acid binding	Losses
AFLOR	GO:0003747	translation release factor activity	Losses
AFLOR	GO:0000900	translation repressor activity, nucleic acid binding	Losses
AFLOR	GO:0008079	translation termination factor activity	Losses
AFLOR	GO:0090599	alpha-glucosidase activity	Losses
AFLOR	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
AFLOR	GO:0005507	copper ion binding	Losses
AFLOR	GO:0016886	ligase activity, forming phosphoric ester bonds	Losses
AFLOR	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
AFLOR	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
AFLOR	GO:0004062	aryl sulfotransferase activity	Losses
AFLOR	GO:0004027	alcohol sulfotransferase activity	Losses
AFLOR	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
AFLOR	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
AFLOR	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
AFLOR	GO:0004995	tachykinin receptor activity	Losses
AFLOR	GO:0004950	chemokine receptor activity	Losses
AFLOR	GO:0004946	bombesin receptor activity	Losses
AFLOR	GO:0016532	superoxide dismutase copper chaperone activity	Losses
AFLOR	GO:0008255	ecdysis-triggering hormone activity	Losses
AFLOR	GO:0004325	ferrochelatase activity	Losses
AFLOR	GO:0004329	formate-tetrahydrofolate ligase activity	Losses
AFLOR	GO:0060308	GTP cyclohydrolase I regulator activity	Losses
AFLOR	GO:0004304	estrone sulfotransferase activity	Losses
AFLOR	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
AFLOR	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Losses
AFLOR	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Losses
AFLOR	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
AFLOR	GO:0005222	intracellular cAMP activated cation channel activity	Losses
AFLOR	GO:0005223	intracellular cGMP activated cation channel activity	Losses
AFLOR	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Losses
AFLOR	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Losses
AFLOR	GO:0080132	fatty acid alpha-hydroxylase activity	Losses
AFLOR	GO:0071837	HMG box domain binding	Losses
AFLOR	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
AFLOR	GO:0003680	AT DNA binding	Losses
AFLOR	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
AFLOR	GO:0001106	RNA polymerase II transcription corepressor activity	Losses
AFLOR	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
AFLOR	GO:0004796	thromboxane-A synthase activity	Losses
AFLOR	GO:0035755	cardiolipin hydrolase activity	Losses
AFLOR	GO:0042947	glucoside transmembrane transporter activity	Losses
AFLOR	GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	Losses
AFLOR	GO:0050840	extracellular matrix binding	Losses
AFLOR	GO:0070547	L-tyrosine aminotransferase activity	Losses
AFLOR	GO:0097493	structural molecule activity conferring elasticity	Losses
AFLOR	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Losses
AFLOR	GO:0004573	mannosyl-oligosaccharide glucosidase activity	Losses
AFLOR	GO:0003979	UDP-glucose 6-dehydrogenase activity	Losses
AFLOR	GO:0003911	DNA ligase (NAD+) activity	Losses
AFLOR	GO:0034722	gamma-glutamyl-peptidase activity	Losses
AFLOR	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
AFLOR	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
AFLOR	GO:0052870	tocopherol omega-hydroxylase activity	Losses
AFLOR	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
AFLOR	GO:0042301	phosphate ion binding	Losses
AFLOR	GO:0008903	hydroxypyruvate isomerase activity	Losses
AFLOR	GO:0015574	trehalose transmembrane transporter activity	Losses
AFLOR	GO:0071906	CRD domain binding	Losses
AFLOR	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
AFLOR	GO:0005326	neurotransmitter transporter activity	Losses
AFLOR	GO:0004519	endonuclease activity	Losses
AFLOR	GO:0004888	transmembrane signaling receptor activity	Losses
AFLOR	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AFLOR	GO:0003909	DNA ligase activity	Extinctions
AFLOR	GO:0034061	DNA polymerase activity	Extinctions
AFLOR	GO:0008241	peptidyl-dipeptidase activity	Extinctions
AFLOR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
AFLOR	GO:0140097	catalytic activity, acting on DNA	Extinctions
AFLOR	GO:0005507	copper ion binding	Extinctions
AFLOR	GO:0008238	exopeptidase activity	Extinctions
AFLOR	GO:0016886	ligase activity, forming phosphoric ester bonds	Extinctions
AFLOR	GO:0070001	aspartic-type peptidase activity	Extinctions
AFLOR	GO:0004190	aspartic-type endopeptidase activity	Extinctions
AFLOR	GO:0016532	superoxide dismutase copper chaperone activity	Extinctions
AFLOR	GO:0008255	ecdysis-triggering hormone activity	Extinctions
AFLOR	GO:0004325	ferrochelatase activity	Extinctions
AFLOR	GO:0060308	GTP cyclohydrolase I regulator activity	Extinctions
AFLOR	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Extinctions
AFLOR	GO:0080132	fatty acid alpha-hydroxylase activity	Extinctions
AFLOR	GO:0035755	cardiolipin hydrolase activity	Extinctions
AFLOR	GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	Extinctions
AFLOR	GO:0070547	L-tyrosine aminotransferase activity	Extinctions
AFLOR	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Extinctions
AFLOR	GO:0004573	mannosyl-oligosaccharide glucosidase activity	Extinctions
AFLOR	GO:0003979	UDP-glucose 6-dehydrogenase activity	Extinctions
AFLOR	GO:0003911	DNA ligase (NAD+) activity	Extinctions
AFLOR	GO:0034722	gamma-glutamyl-peptidase activity	Extinctions
AFLOR	GO:0008903	hydroxypyruvate isomerase activity	Extinctions
AFLOR	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
AFLOR	GO:0001096	TFIIF-class transcription factor binding	Extinctions
AFLOR	GO:0015095	magnesium ion transmembrane transporter activity	Extinctions
AFLOR	GO:0051371	muscle alpha-actinin binding	Extinctions
AFLOR	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	Extinctions
AFLOR	GO:0016531	copper chaperone activity	Extinctions
AFLOR	GO:0015927	trehalase activity	Extinctions
AFLOR	GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	Extinctions
AFLOR	GO:0004307	ethanolaminephosphotransferase activity	Extinctions
AFLOR	GO:0033170	protein-DNA loading ATPase activity	Extinctions
AFLOR	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Extinctions
AFLOR	GO:0004427	inorganic diphosphatase activity	Extinctions
AFLOR	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	Extinctions
AFLOR	GO:0004142	diacylglycerol cholinephosphotransferase activity	Extinctions
AFLOR	GO:0019789	SUMO transferase activity	Extinctions
AFLOR	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	Extinctions
AFLOR	GO:0035100	ecdysone binding	Extinctions
AFLOR	GO:0003689	DNA clamp loader activity	Extinctions
AFLOR	GO:0004555	alpha,alpha-trehalase activity	Extinctions
AFLOR	GO:0003934	GTP cyclohydrolase I activity	Extinctions
AFLOR	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	Extinctions
DI25	GO:0042803	protein homodimerization activity	Gains
DI25	GO:0004000	adenosine deaminase activity	Gains
DI25	GO:0042802	identical protein binding	Gains
DI25	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
DI25	GO:0019239	deaminase activity	Gains
DI25	GO:0046983	protein dimerization activity	Gains
DI25	GO:0008307	structural constituent of muscle	Gains
DI25	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
DI25	GO:0000976	transcription regulatory region sequence-specific DNA binding	Gains
DI25	GO:0045296	cadherin binding	Gains
DI25	GO:1990837	sequence-specific double-stranded DNA binding	Gains
DI25	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
DI25	GO:0008061	chitin binding	Gains
DI25	GO:0004576	oligosaccharyl transferase activity	Gains
DI25	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Gains
DI25	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DI25	GO:0004104	cholinesterase activity	Gains
DI25	GO:0016019	peptidoglycan receptor activity	Gains
DI25	GO:0008531	riboflavin kinase activity	Gains
DI25	GO:0001875	lipopolysaccharide receptor activity	Gains
DI25	GO:0008046	axon guidance receptor activity	Gains
DI25	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Gains
DI25	GO:0035650	AP-1 adaptor complex binding	Gains
DI25	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Gains
DI25	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	Gains
DI25	GO:0003726	double-stranded RNA adenosine deaminase activity	Gains
DI25	GO:0032500	muramyl dipeptide binding	Gains
DI25	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
DI25	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
DI25	GO:0044212	transcription regulatory region DNA binding	Gains
DI25	GO:0003690	double-stranded DNA binding	Gains
DI25	GO:0001067	regulatory region nucleic acid binding	Gains
DI25	GO:0000975	regulatory region DNA binding	Gains
DI25	GO:0050839	cell adhesion molecule binding	Gains
DI25	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
DI25	GO:0001012	RNA polymerase II regulatory region DNA binding	Gains
DI25	GO:0051287	NAD binding	Gains
DI25	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
DI25	GO:0042302	structural constituent of cuticle	Losses
DI25	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
DI25	GO:0004871	signal transducer activity	Losses
DI25	GO:0005214	structural constituent of chitin-based cuticle	Losses
DI25	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
DI25	GO:0005000	vasopressin receptor activity	Losses
DI25	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
DI25	GO:0008395	steroid hydroxylase activity	Losses
DI25	GO:0008270	zinc ion binding	Losses
DI25	GO:0015291	secondary active transmembrane transporter activity	Losses
DI25	GO:0019798	procollagen-proline dioxygenase activity	Losses
DI25	GO:0015293	symporter activity	Losses
DI25	GO:0046914	transition metal ion binding	Losses
DI25	GO:0005198	structural molecule activity	Losses
DI25	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
DI25	GO:0005326	neurotransmitter transporter activity	Losses
DI25	GO:0070330	aromatase activity	Losses
DI25	GO:0031543	peptidyl-proline dioxygenase activity	Losses
DI25	GO:0022821	potassium ion antiporter activity	Losses
DI25	GO:0015368	calcium:cation antiporter activity	Losses
DI25	GO:0015298	solute:cation antiporter activity	Losses
DI25	GO:0004872	receptor activity	Losses
DI25	GO:0005109	frizzled binding	Losses
DI25	GO:0015297	antiporter activity	Losses
DI25	GO:0003960	NADPH:quinone reductase activity	Losses
DI25	GO:0099600	transmembrane receptor activity	Losses
DI25	GO:0060089	molecular transducer activity	Losses
DI25	GO:0038023	signaling receptor activity	Losses
DI25	GO:0015144	carbohydrate transmembrane transporter activity	Losses
DI25	GO:0003990	acetylcholinesterase activity	Losses
DI25	GO:0051119	sugar transmembrane transporter activity	Losses
DI25	GO:0030246	carbohydrate binding	Losses
DI25	GO:0008188	neuropeptide receptor activity	Losses
DI25	GO:0019797	procollagen-proline 3-dioxygenase activity	Losses
DI25	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
DI25	GO:0005521	lamin binding	Losses
DI25	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
DI25	GO:0019811	cocaine binding	Losses
DI25	GO:0050700	CARD domain binding	Losses
DI25	GO:0042943	D-amino acid transmembrane transporter activity	Losses
DI25	GO:0042947	glucoside transmembrane transporter activity	Losses
DI25	GO:0015222	serotonin transmembrane transporter activity	Losses
DI25	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
DI25	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Losses
DI25	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity	Losses
DI25	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
DI25	GO:0002151	G-quadruplex RNA binding	Losses
DI25	GO:0001587	Gq/11-coupled serotonin receptor activity	Losses
DI25	GO:0036132	13-prostaglandin reductase activity	Losses
DI25	GO:0016427	tRNA (cytosine) methyltransferase activity	Losses
DI25	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	Losses
DI25	GO:0050613	delta14-sterol reductase activity	Losses
DI25	GO:0004633	phosphopantothenoylcysteine decarboxylase activity	Losses
DI25	GO:0015574	trehalose transmembrane transporter activity	Losses
DI25	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
DI25	GO:0004037	allantoicase activity	Losses
DI25	GO:0008331	high voltage-gated calcium channel activity	Losses
DI25	GO:0042263	neuropeptide F receptor activity	Losses
DI25	GO:0031544	peptidyl-proline 3-dioxygenase activity	Losses
DI25	GO:0005329	dopamine transmembrane transporter activity	Losses
DI25	GO:0035013	myosuppressin receptor activity	Losses
DI25	GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Losses
DI25	GO:0005164	tumor necrosis factor receptor binding	Losses
DI25	GO:0004352	glutamate dehydrogenase (NAD+) activity	Losses
DI25	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Losses
DI25	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
DI25	GO:0032813	tumor necrosis factor receptor superfamily binding	Losses
DI25	GO:0047886	farnesol dehydrogenase activity	Losses
DI25	GO:0004465	lipoprotein lipase activity	Losses
DI25	GO:0003873	6-phosphofructo-2-kinase activity	Losses
DI25	GO:0047598	7-dehydrocholesterol reductase activity	Losses
DI25	GO:0019113	limonene monooxygenase activity	Losses
DI25	GO:0035302	ecdysteroid 25-hydroxylase activity	Losses
DI25	GO:0019135	deoxyhypusine monooxygenase activity	Losses
DI25	GO:0071861	tachykinin receptor binding	Losses
DI25	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
DI25	GO:0046872	metal ion binding	Losses
DI25	GO:0019798	procollagen-proline dioxygenase activity	Extinctions
DI25	GO:0031543	peptidyl-proline dioxygenase activity	Extinctions
DI25	GO:0005109	frizzled binding	Extinctions
DI25	GO:0004871	signal transducer activity	Extinctions
DI25	GO:0008395	steroid hydroxylase activity	Extinctions
DI25	GO:0003735	structural constituent of ribosome	Extinctions
DI25	GO:0031418	L-ascorbic acid binding	Extinctions
DI25	GO:0004803	transposase activity	Extinctions
DI25	GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
DI25	GO:0005521	lamin binding	Extinctions
DI25	GO:0050700	CARD domain binding	Extinctions
DI25	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	Extinctions
DI25	GO:0002151	G-quadruplex RNA binding	Extinctions
DI25	GO:0001587	Gq/11-coupled serotonin receptor activity	Extinctions
DI25	GO:0016427	tRNA (cytosine) methyltransferase activity	Extinctions
DI25	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	Extinctions
DI25	GO:0050613	delta14-sterol reductase activity	Extinctions
DI25	GO:0004633	phosphopantothenoylcysteine decarboxylase activity	Extinctions
DI25	GO:0004037	allantoicase activity	Extinctions
DI25	GO:0042263	neuropeptide F receptor activity	Extinctions
DI25	GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
DI25	GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Extinctions
DI25	GO:0005164	tumor necrosis factor receptor binding	Extinctions
DI25	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Extinctions
DI25	GO:0032813	tumor necrosis factor receptor superfamily binding	Extinctions
DI25	GO:0003873	6-phosphofructo-2-kinase activity	Extinctions
DI25	GO:0047598	7-dehydrocholesterol reductase activity	Extinctions
DI25	GO:0035302	ecdysteroid 25-hydroxylase activity	Extinctions
DI25	GO:0019135	deoxyhypusine monooxygenase activity	Extinctions
DI25	GO:0071861	tachykinin receptor binding	Extinctions
DI25	GO:0005198	structural molecule activity	Extinctions
DI25	GO:0048029	monosaccharide binding	Extinctions
DI25	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Extinctions
DI25	GO:0005326	neurotransmitter transporter activity	Extinctions
DI25	GO:0070330	aromatase activity	Extinctions
BGERM	GO:0003824	catalytic activity	Gains
BGERM	GO:0140097	catalytic activity, acting on DNA	Gains
BGERM	GO:0043168	anion binding	Gains
BGERM	GO:0032559	adenyl ribonucleotide binding	Gains
BGERM	GO:0005524	ATP binding	Gains
BGERM	GO:0003964	RNA-directed DNA polymerase activity	Gains
BGERM	GO:0030554	adenyl nucleotide binding	Gains
BGERM	GO:0034061	DNA polymerase activity	Gains
BGERM	GO:0036094	small molecule binding	Gains
BGERM	GO:0032553	ribonucleotide binding	Gains
BGERM	GO:0097367	carbohydrate derivative binding	Gains
BGERM	GO:0004812	aminoacyl-tRNA ligase activity	Gains
BGERM	GO:0016787	hydrolase activity	Gains
BGERM	GO:0048037	cofactor binding	Gains
BGERM	GO:0032555	purine ribonucleotide binding	Gains
BGERM	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
BGERM	GO:0035639	purine ribonucleoside triphosphate binding	Gains
BGERM	GO:0017076	purine nucleotide binding	Gains
BGERM	GO:0000156	phosphorelay response regulator activity	Gains
BGERM	GO:0016829	lyase activity	Gains
BGERM	GO:1901265	nucleoside phosphate binding	Gains
BGERM	GO:0000166	nucleotide binding	Gains
BGERM	GO:0016779	nucleotidyltransferase activity	Gains
BGERM	GO:0004518	nuclease activity	Gains
BGERM	GO:0016491	oxidoreductase activity	Gains
BGERM	GO:0017111	nucleoside-triphosphatase activity	Gains
BGERM	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
BGERM	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
BGERM	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
BGERM	GO:0016462	pyrophosphatase activity	Gains
BGERM	GO:0097159	organic cyclic compound binding	Gains
BGERM	GO:1901363	heterocyclic compound binding	Gains
BGERM	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
BGERM	GO:0003678	DNA helicase activity	Gains
BGERM	GO:0019199	transmembrane receptor protein kinase activity	Gains
BGERM	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
BGERM	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
BGERM	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
BGERM	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
BGERM	GO:0140098	catalytic activity, acting on RNA	Gains
BGERM	GO:0043167	ion binding	Gains
BGERM	GO:0061783	peptidoglycan muralytic activity	Gains
BGERM	GO:0004519	endonuclease activity	Gains
BGERM	GO:0016849	phosphorus-oxygen lyase activity	Gains
BGERM	GO:0015291	secondary active transmembrane transporter activity	Gains
BGERM	GO:0015081	sodium ion transmembrane transporter activity	Gains
BGERM	GO:0017048	Rho GTPase binding	Gains
BGERM	GO:0015293	symporter activity	Gains
BGERM	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
BGERM	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
BGERM	GO:0010181	FMN binding	Gains
BGERM	GO:0050662	coenzyme binding	Gains
BGERM	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
BGERM	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
BGERM	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
BGERM	GO:0015294	solute:cation symporter activity	Gains
BGERM	GO:0004386	helicase activity	Gains
BGERM	GO:0048365	Rac GTPase binding	Gains
BGERM	GO:0005534	galactose binding	Gains
BGERM	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
BGERM	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
BGERM	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Gains
BGERM	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
BGERM	GO:0140101	catalytic activity, acting on a tRNA	Gains
BGERM	GO:0022804	active transmembrane transporter activity	Gains
BGERM	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
BGERM	GO:0019842	vitamin binding	Gains
BGERM	GO:0016597	amino acid binding	Gains
BGERM	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
BGERM	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
BGERM	GO:0019200	carbohydrate kinase activity	Gains
BGERM	GO:0004673	protein histidine kinase activity	Gains
BGERM	GO:0030246	carbohydrate binding	Gains
BGERM	GO:0004540	ribonuclease activity	Gains
BGERM	GO:0004070	aspartate carbamoyltransferase activity	Gains
BGERM	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
BGERM	GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
BGERM	GO:0004818	glutamate-tRNA ligase activity	Gains
BGERM	GO:0017016	Ras GTPase binding	Gains
BGERM	GO:0004527	exonuclease activity	Gains
BGERM	GO:0016836	hydro-lyase activity	Gains
BGERM	GO:0008408	3'-5' exonuclease activity	Gains
BGERM	GO:0030170	pyridoxal phosphate binding	Gains
BGERM	GO:0070279	vitamin B6 binding	Gains
BGERM	GO:0046873	metal ion transmembrane transporter activity	Gains
BGERM	GO:0005272	sodium channel activity	Gains
BGERM	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
BGERM	GO:0031267	small GTPase binding	Gains
BGERM	GO:0070008	serine-type exopeptidase activity	Gains
BGERM	GO:0002161	aminoacyl-tRNA editing activity	Gains
BGERM	GO:0019104	DNA N-glycosylase activity	Gains
BGERM	GO:0015645	fatty acid ligase activity	Gains
BGERM	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
BGERM	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	Gains
BGERM	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
BGERM	GO:0008519	ammonium transmembrane transporter activity	Gains
BGERM	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
BGERM	GO:0016887	ATPase activity	Gains
BGERM	GO:0000155	phosphorelay sensor kinase activity	Gains
BGERM	GO:0030983	mismatched DNA binding	Gains
BGERM	GO:0003725	double-stranded RNA binding	Gains
BGERM	GO:0032296	double-stranded RNA-specific ribonuclease activity	Gains
BGERM	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
BGERM	GO:0003796	lysozyme activity	Gains
BGERM	GO:0016805	dipeptidase activity	Gains
BGERM	GO:0004525	ribonuclease III activity	Gains
BGERM	GO:0004622	lysophospholipase activity	Gains
BGERM	GO:0099094	ligand-gated cation channel activity	Gains
BGERM	GO:0005261	cation channel activity	Gains
BGERM	GO:0016835	carbon-oxygen lyase activity	Gains
BGERM	GO:0043177	organic acid binding	Gains
BGERM	GO:0009975	cyclase activity	Gains
BGERM	GO:0031406	carboxylic acid binding	Gains
BGERM	GO:0015370	solute:sodium symporter activity	Gains
BGERM	GO:0008233	peptidase activity	Gains
BGERM	GO:0016763	transferase activity, transferring pentosyl groups	Gains
BGERM	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
BGERM	GO:0070001	aspartic-type peptidase activity	Gains
BGERM	GO:0004190	aspartic-type endopeptidase activity	Gains
BGERM	GO:0008234	cysteine-type peptidase activity	Gains
BGERM	GO:0016874	ligase activity	Gains
BGERM	GO:0003933	GTP cyclohydrolase activity	Gains
BGERM	GO:0004634	phosphopyruvate hydratase activity	Gains
BGERM	GO:0008658	penicillin binding	Gains
BGERM	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Gains
BGERM	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
BGERM	GO:0004033	aldo-keto reductase (NADP) activity	Gains
BGERM	GO:0004035	alkaline phosphatase activity	Gains
BGERM	GO:0016149	translation release factor activity, codon specific	Gains
BGERM	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Gains
BGERM	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	Gains
BGERM	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Gains
BGERM	GO:0008447	L-ascorbate oxidase activity	Gains
BGERM	GO:0030898	actin-dependent ATPase activity	Gains
BGERM	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	Gains
BGERM	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
BGERM	GO:0018454	acetoacetyl-CoA reductase activity	Gains
BGERM	GO:0004736	pyruvate carboxylase activity	Gains
BGERM	GO:0009378	four-way junction helicase activity	Gains
BGERM	GO:0004815	aspartate-tRNA ligase activity	Gains
BGERM	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
BGERM	GO:0005201	extracellular matrix structural constituent	Gains
BGERM	GO:0008238	exopeptidase activity	Gains
BGERM	GO:0043565	sequence-specific DNA binding	Losses
BGERM	GO:0003700	DNA binding transcription factor activity	Losses
BGERM	GO:0140110	transcription regulator activity	Losses
BGERM	GO:0004871	signal transducer activity	Losses
BGERM	GO:0004888	transmembrane signaling receptor activity	Losses
BGERM	GO:0008528	G-protein coupled peptide receptor activity	Losses
BGERM	GO:0004930	G-protein coupled receptor activity	Losses
BGERM	GO:0001653	peptide receptor activity	Losses
BGERM	GO:0005549	odorant binding	Losses
BGERM	GO:0004000	adenosine deaminase activity	Losses
BGERM	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
BGERM	GO:0008188	neuropeptide receptor activity	Losses
BGERM	GO:0038023	signaling receptor activity	Losses
BGERM	GO:1990837	sequence-specific double-stranded DNA binding	Losses
BGERM	GO:0099600	transmembrane receptor activity	Losses
BGERM	GO:0019239	deaminase activity	Losses
BGERM	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
BGERM	GO:0044212	transcription regulatory region DNA binding	Losses
BGERM	GO:0000975	regulatory region DNA binding	Losses
BGERM	GO:0001067	regulatory region nucleic acid binding	Losses
BGERM	GO:0008527	taste receptor activity	Losses
BGERM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
BGERM	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
BGERM	GO:0003677	DNA binding	Losses
BGERM	GO:0003690	double-stranded DNA binding	Losses
BGERM	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
BGERM	GO:0030546	receptor activator activity	Losses
BGERM	GO:0060089	molecular transducer activity	Losses
BGERM	GO:0035326	enhancer binding	Losses
BGERM	GO:0001158	enhancer sequence-specific DNA binding	Losses
BGERM	GO:0004872	receptor activity	Losses
BGERM	GO:0004713	protein tyrosine kinase activity	Losses
BGERM	GO:0003681	bent DNA binding	Losses
BGERM	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
BGERM	GO:0019887	protein kinase regulator activity	Losses
BGERM	GO:0030545	receptor regulator activity	Losses
BGERM	GO:0030296	protein tyrosine kinase activator activity	Losses
BGERM	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
BGERM	GO:0019207	kinase regulator activity	Losses
BGERM	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
BGERM	GO:0019209	kinase activator activity	Losses
BGERM	GO:0030295	protein kinase activator activity	Losses
BGERM	GO:0004983	neuropeptide Y receptor activity	Losses
BGERM	GO:0004984	olfactory receptor activity	Losses
BGERM	GO:0004089	carbonate dehydratase activity	Losses
BGERM	GO:0004697	protein kinase C activity	Losses
BGERM	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
BGERM	GO:0004667	prostaglandin-D synthase activity	Losses
BGERM	GO:0005213	structural constituent of chorion	Losses
BGERM	GO:0098988	G-protein coupled glutamate receptor activity	Losses
BGERM	GO:0019153	protein-disulfide reductase (glutathione) activity	Losses
BGERM	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
BGERM	GO:0033188	sphingomyelin synthase activity	Losses
BGERM	GO:0015204	urea transmembrane transporter activity	Losses
BGERM	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
BGERM	GO:0004061	arylformamidase activity	Losses
BGERM	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Losses
BGERM	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Losses
BGERM	GO:0016499	orexin receptor activity	Losses
BGERM	GO:0005550	pheromone binding	Losses
BGERM	GO:0030331	estrogen receptor binding	Losses
BGERM	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
BGERM	GO:0008022	protein C-terminus binding	Losses
BGERM	GO:0008048	calcium sensitive guanylate cyclase activator activity	Losses
BGERM	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Losses
BGERM	GO:0001641	group II metabotropic glutamate receptor activity	Losses
BGERM	GO:0042979	ornithine decarboxylase regulator activity	Losses
BGERM	GO:0033878	hormone-sensitive lipase activity	Losses
BGERM	GO:0004398	histidine decarboxylase activity	Losses
BGERM	GO:0030250	guanylate cyclase activator activity	Losses
BGERM	GO:0030249	guanylate cyclase regulator activity	Losses
BGERM	GO:0005031	tumor necrosis factor-activated receptor activity	Losses
BGERM	GO:0005035	death receptor activity	Losses
BGERM	GO:0008459	chondroitin 6-sulfotransferase activity	Losses
BGERM	GO:0032028	myosin head/neck binding	Losses
BGERM	GO:0031489	myosin V binding	Losses
BGERM	GO:0070854	myosin VI heavy chain binding	Losses
BGERM	GO:0070855	myosin VI head/neck binding	Losses
BGERM	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Losses
BGERM	GO:0005436	sodium:phosphate symporter activity	Losses
BGERM	GO:0035755	cardiolipin hydrolase activity	Losses
BGERM	GO:0010851	cyclase regulator activity	Losses
BGERM	GO:0010853	cyclase activator activity	Losses
BGERM	GO:0036401	pyrokinin receptor activity	Losses
BGERM	GO:0047493	ceramide cholinephosphotransferase activity	Losses
BGERM	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
BGERM	GO:0032450	maltose alpha-glucosidase activity	Losses
BGERM	GO:0003964	RNA-directed DNA polymerase activity	Losses
BGERM	GO:0043565	sequence-specific DNA binding	Extinctions
BGERM	GO:0003700	DNA binding transcription factor activity	Extinctions
BGERM	GO:0140110	transcription regulator activity	Extinctions
BGERM	GO:0004000	adenosine deaminase activity	Extinctions
BGERM	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
BGERM	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
BGERM	GO:0005549	odorant binding	Extinctions
BGERM	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
BGERM	GO:0019239	deaminase activity	Extinctions
BGERM	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
BGERM	GO:0044212	transcription regulatory region DNA binding	Extinctions
BGERM	GO:0000975	regulatory region DNA binding	Extinctions
BGERM	GO:0001067	regulatory region nucleic acid binding	Extinctions
BGERM	GO:0004871	signal transducer activity	Extinctions
BGERM	GO:0003690	double-stranded DNA binding	Extinctions
BGERM	GO:0008188	neuropeptide receptor activity	Extinctions
BGERM	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
BGERM	GO:0030546	receptor activator activity	Extinctions
BGERM	GO:0003677	DNA binding	Extinctions
BGERM	GO:0035326	enhancer binding	Extinctions
BGERM	GO:0001158	enhancer sequence-specific DNA binding	Extinctions
BGERM	GO:0004888	transmembrane signaling receptor activity	Extinctions
BGERM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Extinctions
BGERM	GO:0004930	G-protein coupled receptor activity	Extinctions
BGERM	GO:0038023	signaling receptor activity	Extinctions
BGERM	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
BGERM	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
BGERM	GO:0001653	peptide receptor activity	Extinctions
BGERM	GO:0003681	bent DNA binding	Extinctions
BGERM	GO:0099600	transmembrane receptor activity	Extinctions
BGERM	GO:0030296	protein tyrosine kinase activator activity	Extinctions
BGERM	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Extinctions
BGERM	GO:0001012	RNA polymerase II regulatory region DNA binding	Extinctions
BGERM	GO:0003676	nucleic acid binding	Extinctions
BGERM	GO:0008527	taste receptor activity	Extinctions
BGERM	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Extinctions
BGERM	GO:0019209	kinase activator activity	Extinctions
BGERM	GO:0030295	protein kinase activator activity	Extinctions
BGERM	GO:0030545	receptor regulator activity	Extinctions
BGERM	GO:0032450	maltose alpha-glucosidase activity	Extinctions
BGERM	GO:0004872	receptor activity	Extinctions
BGERM	GO:0005213	structural constituent of chorion	Extinctions
BGERM	GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
BGERM	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
BGERM	GO:0042654	ecdysis-triggering hormone receptor activity	Extinctions
BGERM	GO:0033188	sphingomyelin synthase activity	Extinctions
BGERM	GO:0015204	urea transmembrane transporter activity	Extinctions
BGERM	GO:0004997	thyrotropin-releasing hormone receptor activity	Extinctions
BGERM	GO:0004061	arylformamidase activity	Extinctions
BGERM	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Extinctions
BGERM	GO:0016499	orexin receptor activity	Extinctions
BGERM	GO:0005550	pheromone binding	Extinctions
BGERM	GO:0030331	estrogen receptor binding	Extinctions
BGERM	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
BGERM	GO:0008022	protein C-terminus binding	Extinctions
BGERM	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
BGERM	GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
BGERM	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
BGERM	GO:0033878	hormone-sensitive lipase activity	Extinctions
BGERM	GO:0005031	tumor necrosis factor-activated receptor activity	Extinctions
BGERM	GO:0005035	death receptor activity	Extinctions
BGERM	GO:0008459	chondroitin 6-sulfotransferase activity	Extinctions
BGERM	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
BGERM	GO:0035755	cardiolipin hydrolase activity	Extinctions
BGERM	GO:0047493	ceramide cholinephosphotransferase activity	Extinctions
BGERM	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
BGERM	GO:0019901	protein kinase binding	Extinctions
BGERM	GO:0042826	histone deacetylase binding	Extinctions
BGERM	GO:0090599	alpha-glucosidase activity	Extinctions
BGERM	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
COPFL	GO:0003676	nucleic acid binding	Gains
COPFL	GO:0003964	RNA-directed DNA polymerase activity	Gains
COPFL	GO:0034061	DNA polymerase activity	Gains
COPFL	GO:1901363	heterocyclic compound binding	Gains
COPFL	GO:0097159	organic cyclic compound binding	Gains
COPFL	GO:0016779	nucleotidyltransferase activity	Gains
COPFL	GO:0140097	catalytic activity, acting on DNA	Gains
COPFL	GO:0003677	DNA binding	Gains
COPFL	GO:0008270	zinc ion binding	Gains
COPFL	GO:0046914	transition metal ion binding	Gains
COPFL	GO:0005488	binding	Gains
COPFL	GO:0005516	calmodulin binding	Gains
COPFL	GO:0043169	cation binding	Gains
COPFL	GO:0046872	metal ion binding	Gains
COPFL	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
COPFL	GO:0004190	aspartic-type endopeptidase activity	Gains
COPFL	GO:0070001	aspartic-type peptidase activity	Gains
COPFL	GO:0005243	gap junction channel activity	Gains
COPFL	GO:0004485	methylcrotonoyl-CoA carboxylase activity	Gains
COPFL	GO:0004415	hyalurononglucosaminidase activity	Gains
COPFL	GO:0043874	acireductone synthase activity	Gains
COPFL	GO:0004993	G-protein coupled serotonin receptor activity	Gains
COPFL	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
COPFL	GO:0099589	serotonin receptor activity	Gains
COPFL	GO:0050254	rhodopsin kinase activity	Gains
COPFL	GO:0004983	neuropeptide Y receptor activity	Gains
COPFL	GO:0004143	diacylglycerol kinase activity	Gains
COPFL	GO:0004518	nuclease activity	Gains
COPFL	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
COPFL	GO:0015370	solute:sodium symporter activity	Gains
COPFL	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
COPFL	GO:0015267	channel activity	Gains
COPFL	GO:0022803	passive transmembrane transporter activity	Gains
COPFL	GO:0003951	NAD+ kinase activity	Gains
COPFL	GO:0097157	pre-mRNA intronic binding	Gains
COPFL	GO:0004977	melanocortin receptor activity	Gains
COPFL	GO:0008261	allatostatin receptor activity	Gains
COPFL	GO:0004342	glucosamine-6-phosphate deaminase activity	Gains
COPFL	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Gains
COPFL	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Gains
COPFL	GO:0004102	choline O-acetyltransferase activity	Gains
COPFL	GO:0051864	histone demethylase activity (H3-K36 specific)	Gains
COPFL	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
COPFL	GO:0005262	calcium channel activity	Gains
COPFL	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
COPFL	GO:0016615	malate dehydrogenase activity	Losses
COPFL	GO:0015179	L-amino acid transmembrane transporter activity	Losses
COPFL	GO:0005416	cation:amino acid symporter activity	Losses
COPFL	GO:0005283	sodium:amino acid symporter activity	Losses
COPFL	GO:0004984	olfactory receptor activity	Losses
COPFL	GO:0030060	L-malate dehydrogenase activity	Losses
COPFL	GO:0005313	L-glutamate transmembrane transporter activity	Losses
COPFL	GO:0015172	acidic amino acid transmembrane transporter activity	Losses
COPFL	GO:0005310	dicarboxylic acid transmembrane transporter activity	Losses
COPFL	GO:0030882	lipid antigen binding	Losses
COPFL	GO:0015501	glutamate:sodium symporter activity	Losses
COPFL	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
COPFL	GO:0070891	lipoteichoic acid binding	Losses
COPFL	GO:0036122	BMP binding	Losses
COPFL	GO:0015183	L-aspartate transmembrane transporter activity	Losses
COPFL	GO:0004503	monophenol monooxygenase activity	Losses
COPFL	GO:0001530	lipopolysaccharide binding	Losses
COPFL	GO:0005549	odorant binding	Losses
COPFL	GO:0005342	organic acid transmembrane transporter activity	Losses
COPFL	GO:0046943	carboxylic acid transmembrane transporter activity	Losses
COPFL	GO:0034061	DNA polymerase activity	Losses
COPFL	GO:0016491	oxidoreductase activity	Losses
COPFL	GO:0005343	organic acid:sodium symporter activity	Losses
COPFL	GO:0008028	monocarboxylic acid transmembrane transporter activity	Losses
COPFL	GO:0015081	sodium ion transmembrane transporter activity	Losses
COPFL	GO:0009055	electron transfer activity	Losses
COPFL	GO:0015294	solute:cation symporter activity	Losses
COPFL	GO:0008378	galactosyltransferase activity	Losses
COPFL	GO:0043394	proteoglycan binding	Losses
COPFL	GO:0043395	heparan sulfate proteoglycan binding	Losses
COPFL	GO:0003823	antigen binding	Losses
COPFL	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
COPFL	GO:0008514	organic anion transmembrane transporter activity	Losses
COPFL	GO:0140097	catalytic activity, acting on DNA	Losses
COPFL	GO:0003964	RNA-directed DNA polymerase activity	Losses
COPFL	GO:0015370	solute:sodium symporter activity	Losses
COPFL	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
COPFL	GO:0004175	endopeptidase activity	Losses
COPFL	GO:0004252	serine-type endopeptidase activity	Losses
COPFL	GO:0051537	2 iron, 2 sulfur cluster binding	Losses
COPFL	GO:0004190	aspartic-type endopeptidase activity	Losses
COPFL	GO:0070001	aspartic-type peptidase activity	Losses
COPFL	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
COPFL	GO:0048038	quinone binding	Losses
COPFL	GO:0004064	arylesterase activity	Losses
COPFL	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Losses
COPFL	GO:0008253	5'-nucleotidase activity	Losses
COPFL	GO:0042834	peptidoglycan binding	Losses
COPFL	GO:0017153	sodium:dicarboxylate symporter activity	Losses
COPFL	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	Losses
COPFL	GO:0001105	RNA polymerase II transcription coactivator activity	Losses
COPFL	GO:0001664	G-protein coupled receptor binding	Losses
COPFL	GO:0015291	secondary active transmembrane transporter activity	Losses
COPFL	GO:0015293	symporter activity	Losses
COPFL	GO:0015002	heme-copper terminal oxidase activity	Losses
COPFL	GO:0004129	cytochrome-c oxidase activity	Losses
COPFL	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
COPFL	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
COPFL	GO:0016757	transferase activity, transferring glycosyl groups	Losses
COPFL	GO:0008236	serine-type peptidase activity	Losses
COPFL	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
COPFL	GO:0017171	serine hydrolase activity	Losses
COPFL	GO:0008430	selenium binding	Losses
COPFL	GO:0019955	cytokine binding	Losses
COPFL	GO:0009008	DNA-methyltransferase activity	Losses
COPFL	GO:0001102	RNA polymerase II activating transcription factor binding	Losses
COPFL	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
COPFL	GO:0008276	protein methyltransferase activity	Losses
COPFL	GO:0016763	transferase activity, transferring pentosyl groups	Losses
COPFL	GO:0004497	monooxygenase activity	Losses
COPFL	GO:0030882	lipid antigen binding	Extinctions
COPFL	GO:0070891	lipoteichoic acid binding	Extinctions
COPFL	GO:0001530	lipopolysaccharide binding	Extinctions
COPFL	GO:0016615	malate dehydrogenase activity	Extinctions
COPFL	GO:0003823	antigen binding	Extinctions
COPFL	GO:0004984	olfactory receptor activity	Extinctions
COPFL	GO:0015002	heme-copper terminal oxidase activity	Extinctions
COPFL	GO:0004129	cytochrome-c oxidase activity	Extinctions
COPFL	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
COPFL	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
COPFL	GO:0004064	arylesterase activity	Extinctions
COPFL	GO:0042834	peptidoglycan binding	Extinctions
COPFL	GO:0030060	L-malate dehydrogenase activity	Extinctions
COPFL	GO:0005549	odorant binding	Extinctions
COPFL	GO:0005313	L-glutamate transmembrane transporter activity	Extinctions
COPFL	GO:0008430	selenium binding	Extinctions
COPFL	GO:0015172	acidic amino acid transmembrane transporter activity	Extinctions
COPFL	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Extinctions
COPFL	GO:0015179	L-amino acid transmembrane transporter activity	Extinctions
COPFL	GO:0140104	molecular carrier activity	Extinctions
COPFL	GO:0051119	sugar transmembrane transporter activity	Extinctions
COPFL	GO:0015144	carbohydrate transmembrane transporter activity	Extinctions
COPFL	GO:0001664	G-protein coupled receptor binding	Extinctions
COPFL	GO:0009055	electron transfer activity	Extinctions
COPFL	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Extinctions
COPFL	GO:0043916	DNA-7-methylguanine glycosylase activity	Extinctions
COPFL	GO:0005368	taurine transmembrane transporter activity	Extinctions
COPFL	GO:0005369	taurine:sodium symporter activity	Extinctions
COPFL	GO:0004056	argininosuccinate lyase activity	Extinctions
COPFL	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Extinctions
COPFL	GO:0004020	adenylylsulfate kinase activity	Extinctions
COPFL	GO:0052821	DNA-7-methyladenine glycosylase activity	Extinctions
COPFL	GO:0052822	DNA-3-methylguanine glycosylase activity	Extinctions
COPFL	GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	Extinctions
COPFL	GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	Extinctions
COPFL	GO:0004997	thyrotropin-releasing hormone receptor activity	Extinctions
COPFL	GO:0051019	mitogen-activated protein kinase binding	Extinctions
COPFL	GO:0034986	iron chaperone activity	Extinctions
COPFL	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
COPFL	GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
COPFL	GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	Extinctions
COPFL	GO:0016727	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor	Extinctions
COPFL	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Extinctions
COPFL	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
COPFL	GO:0008768	UDP-sugar diphosphatase activity	Extinctions
COPFL	GO:0008725	DNA-3-methyladenine glycosylase activity	Extinctions
COPFL	GO:0033867	Fas-activated serine/threonine kinase activity	Extinctions
COPFL	GO:0002094	polyprenyltransferase activity	Extinctions
COPFL	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	Extinctions
COPFL	GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	Extinctions
COPFL	GO:0008887	glycerate kinase activity	Extinctions
COPFL	GO:0042654	ecdysis-triggering hormone receptor activity	Extinctions
COPFL	GO:0036400	short neuropeptide F receptor activity	Extinctions
COPFL	GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
COPFL	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
COPFL	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
COPFL	GO:0043733	DNA-3-methylbase glycosylase activity	Extinctions
COPFL	GO:0016618	hydroxypyruvate reductase activity	Extinctions
COPFL	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Extinctions
COPFL	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
COPFL	GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
COPFL	GO:0042925	benzoate transmembrane transporter activity	Extinctions
COPFL	GO:0004854	xanthine dehydrogenase activity	Extinctions
COPFL	GO:0004855	xanthine oxidase activity	Extinctions
COPFL	GO:0004845	uracil phosphoribosyltransferase activity	Extinctions
COPFL	GO:0004846	urate oxidase activity	Extinctions
COPFL	GO:0004590	orotidine-5'-phosphate decarboxylase activity	Extinctions
COPFL	GO:0004588	orotate phosphoribosyltransferase activity	Extinctions
COPFL	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Extinctions
COPFL	GO:0008986	pyruvate, water dikinase activity	Extinctions
COPFL	GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
COPFL	GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
COPFL	GO:0003905	alkylbase DNA N-glycosylase activity	Extinctions
EAFFI	GO:0004872	receptor activity	Gains
EAFFI	GO:0060089	molecular transducer activity	Gains
EAFFI	GO:0038023	signaling receptor activity	Gains
EAFFI	GO:0015081	sodium ion transmembrane transporter activity	Gains
EAFFI	GO:0099600	transmembrane receptor activity	Gains
EAFFI	GO:0004888	transmembrane signaling receptor activity	Gains
EAFFI	GO:0005216	ion channel activity	Gains
EAFFI	GO:0004871	signal transducer activity	Gains
EAFFI	GO:0022838	substrate-specific channel activity	Gains
EAFFI	GO:0015267	channel activity	Gains
EAFFI	GO:0022803	passive transmembrane transporter activity	Gains
EAFFI	GO:0046873	metal ion transmembrane transporter activity	Gains
EAFFI	GO:0005261	cation channel activity	Gains
EAFFI	GO:0004930	G-protein coupled receptor activity	Gains
EAFFI	GO:0035091	phosphatidylinositol binding	Gains
EAFFI	GO:0017016	Ras GTPase binding	Gains
EAFFI	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
EAFFI	GO:0031267	small GTPase binding	Gains
EAFFI	GO:0017048	Rho GTPase binding	Gains
EAFFI	GO:0022836	gated channel activity	Gains
EAFFI	GO:0051020	GTPase binding	Gains
EAFFI	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
EAFFI	GO:0003779	actin binding	Gains
EAFFI	GO:0005272	sodium channel activity	Gains
EAFFI	GO:0005543	phospholipid binding	Gains
EAFFI	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
EAFFI	GO:0015276	ligand-gated ion channel activity	Gains
EAFFI	GO:0022834	ligand-gated channel activity	Gains
EAFFI	GO:0071949	FAD binding	Gains
EAFFI	GO:0005343	organic acid:sodium symporter activity	Gains
EAFFI	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
EAFFI	GO:0003700	DNA binding transcription factor activity	Gains
EAFFI	GO:0015075	ion transmembrane transporter activity	Gains
EAFFI	GO:0015370	solute:sodium symporter activity	Gains
EAFFI	GO:0005215	transporter activity	Gains
EAFFI	GO:0022890	inorganic cation transmembrane transporter activity	Gains
EAFFI	GO:0043565	sequence-specific DNA binding	Gains
EAFFI	GO:0022857	transmembrane transporter activity	Gains
EAFFI	GO:0008061	chitin binding	Gains
EAFFI	GO:0005230	extracellular ligand-gated ion channel activity	Gains
EAFFI	GO:0015297	antiporter activity	Gains
EAFFI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
EAFFI	GO:0017153	sodium:dicarboxylate symporter activity	Gains
EAFFI	GO:0005375	copper ion transmembrane transporter activity	Gains
EAFFI	GO:0005337	nucleoside transmembrane transporter activity	Gains
EAFFI	GO:0008036	diuretic hormone receptor activity	Gains
EAFFI	GO:0097642	calcitonin family receptor activity	Gains
EAFFI	GO:0004948	calcitonin receptor activity	Gains
EAFFI	GO:0005549	odorant binding	Gains
EAFFI	GO:0033613	activating transcription factor binding	Gains
EAFFI	GO:0015296	anion:cation symporter activity	Gains
EAFFI	GO:0005244	voltage-gated ion channel activity	Gains
EAFFI	GO:0022832	voltage-gated channel activity	Gains
EAFFI	GO:0019899	enzyme binding	Gains
EAFFI	GO:0022891	substrate-specific transmembrane transporter activity	Gains
EAFFI	GO:0099094	ligand-gated cation channel activity	Gains
EAFFI	GO:0022892	substrate-specific transporter activity	Gains
EAFFI	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
EAFFI	GO:0005184	neuropeptide hormone activity	Gains
EAFFI	GO:0005179	hormone activity	Gains
EAFFI	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
EAFFI	GO:0003707	steroid hormone receptor activity	Gains
EAFFI	GO:0048018	receptor ligand activity	Gains
EAFFI	GO:0008324	cation transmembrane transporter activity	Gains
EAFFI	GO:0008270	zinc ion binding	Gains
EAFFI	GO:0016411	acylglycerol O-acyltransferase activity	Gains
EAFFI	GO:0071855	neuropeptide receptor binding	Gains
EAFFI	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
EAFFI	GO:0022843	voltage-gated cation channel activity	Gains
EAFFI	GO:0030545	receptor regulator activity	Gains
EAFFI	GO:0005262	calcium channel activity	Gains
EAFFI	GO:0015291	secondary active transmembrane transporter activity	Gains
EAFFI	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
EAFFI	GO:0003964	RNA-directed DNA polymerase activity	Gains
EAFFI	GO:0005249	voltage-gated potassium channel activity	Gains
EAFFI	GO:0004984	olfactory receptor activity	Gains
EAFFI	GO:0099516	ion antiporter activity	Gains
EAFFI	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	Gains
EAFFI	GO:0008527	taste receptor activity	Gains
EAFFI	GO:0001105	RNA polymerase II transcription coactivator activity	Gains
EAFFI	GO:0008092	cytoskeletal protein binding	Gains
EAFFI	GO:0008134	transcription factor binding	Gains
EAFFI	GO:0005509	calcium ion binding	Gains
EAFFI	GO:0140110	transcription regulator activity	Gains
EAFFI	GO:0003824	catalytic activity	Losses
EAFFI	GO:0016787	hydrolase activity	Losses
EAFFI	GO:0070001	aspartic-type peptidase activity	Losses
EAFFI	GO:0004190	aspartic-type endopeptidase activity	Losses
EAFFI	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
EAFFI	GO:0004175	endopeptidase activity	Losses
EAFFI	GO:0016788	hydrolase activity, acting on ester bonds	Losses
EAFFI	GO:0004952	dopamine neurotransmitter receptor activity	Losses
EAFFI	GO:0004252	serine-type endopeptidase activity	Losses
EAFFI	GO:0042578	phosphoric ester hydrolase activity	Losses
EAFFI	GO:0034061	DNA polymerase activity	Losses
EAFFI	GO:0003963	RNA-3'-phosphate cyclase activity	Losses
EAFFI	GO:0140096	catalytic activity, acting on a protein	Losses
EAFFI	GO:0004806	triglyceride lipase activity	Losses
EAFFI	GO:0008236	serine-type peptidase activity	Losses
EAFFI	GO:0003964	RNA-directed DNA polymerase activity	Losses
EAFFI	GO:0017171	serine hydrolase activity	Losses
EAFFI	GO:0044212	transcription regulatory region DNA binding	Losses
EAFFI	GO:0001067	regulatory region nucleic acid binding	Losses
EAFFI	GO:0000975	regulatory region DNA binding	Losses
EAFFI	GO:0005214	structural constituent of chitin-based cuticle	Losses
EAFFI	GO:1990837	sequence-specific double-stranded DNA binding	Losses
EAFFI	GO:0004983	neuropeptide Y receptor activity	Losses
EAFFI	GO:0033549	MAP kinase phosphatase activity	Losses
EAFFI	GO:1901677	phosphate transmembrane transporter activity	Losses
EAFFI	GO:0015114	phosphate ion transmembrane transporter activity	Losses
EAFFI	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
EAFFI	GO:0008233	peptidase activity	Losses
EAFFI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
EAFFI	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Losses
EAFFI	GO:0016791	phosphatase activity	Losses
EAFFI	GO:0016298	lipase activity	Losses
EAFFI	GO:0004721	phosphoprotein phosphatase activity	Losses
EAFFI	GO:0016409	palmitoyltransferase activity	Losses
EAFFI	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Losses
EAFFI	GO:0008378	galactosyltransferase activity	Losses
EAFFI	GO:0004930	G-protein coupled receptor activity	Losses
EAFFI	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
EAFFI	GO:0070594	juvenile hormone response element binding	Losses
EAFFI	GO:0004095	carnitine O-palmitoyltransferase activity	Losses
EAFFI	GO:0015928	fucosidase activity	Losses
EAFFI	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
EAFFI	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	Losses
EAFFI	GO:0005110	frizzled-2 binding	Losses
EAFFI	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
EAFFI	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
EAFFI	GO:0016454	C-palmitoyltransferase activity	Losses
EAFFI	GO:0004758	serine C-palmitoyltransferase activity	Losses
EAFFI	GO:0016416	O-palmitoyltransferase activity	Losses
EAFFI	GO:0000182	rDNA binding	Losses
EAFFI	GO:0016406	carnitine O-acyltransferase activity	Losses
EAFFI	GO:0004560	alpha-L-fucosidase activity	Losses
EAFFI	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
EAFFI	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
EAFFI	GO:0015462	ATPase-coupled protein transmembrane transporter activity	Losses
EAFFI	GO:0008566	mitochondrial protein-transporting ATPase activity	Losses
EAFFI	GO:0004725	protein tyrosine phosphatase activity	Losses
EAFFI	GO:0048037	cofactor binding	Losses
EAFFI	GO:0016887	ATPase activity	Losses
EAFFI	GO:0035250	UDP-galactosyltransferase activity	Losses
EAFFI	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
EAFFI	GO:0004872	receptor activity	Losses
EAFFI	GO:0009975	cyclase activity	Losses
EAFFI	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
EAFFI	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Losses
EAFFI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
EAFFI	GO:0043492	ATPase activity, coupled to movement of substances	Losses
EAFFI	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
EAFFI	GO:0042623	ATPase activity, coupled	Losses
EAFFI	GO:0005544	calcium-dependent phospholipid binding	Losses
EAFFI	GO:0008081	phosphoric diester hydrolase activity	Losses
EAFFI	GO:0042562	hormone binding	Losses
EAFFI	GO:0008374	O-acyltransferase activity	Losses
EAFFI	GO:0016817	hydrolase activity, acting on acid anhydrides	Losses
EAFFI	GO:0003954	NADH dehydrogenase activity	Losses
EAFFI	GO:0016462	pyrophosphatase activity	Losses
EAFFI	GO:0140097	catalytic activity, acting on DNA	Losses
EAFFI	GO:0060089	molecular transducer activity	Losses
EAFFI	GO:0017111	nucleoside-triphosphatase activity	Losses
EAFFI	GO:0008528	G-protein coupled peptide receptor activity	Losses
EAFFI	GO:0030246	carbohydrate binding	Losses
EAFFI	GO:0008188	neuropeptide receptor activity	Losses
EAFFI	GO:0043565	sequence-specific DNA binding	Losses
EAFFI	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
EAFFI	GO:0015399	primary active transmembrane transporter activity	Losses
EAFFI	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
EAFFI	GO:0004952	dopamine neurotransmitter receptor activity	Extinctions
EAFFI	GO:0016409	palmitoyltransferase activity	Extinctions
EAFFI	GO:0044212	transcription regulatory region DNA binding	Extinctions
EAFFI	GO:0001067	regulatory region nucleic acid binding	Extinctions
EAFFI	GO:0000975	regulatory region DNA binding	Extinctions
EAFFI	GO:0004930	G-protein coupled receptor activity	Extinctions
EAFFI	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
EAFFI	GO:0015462	ATPase-coupled protein transmembrane transporter activity	Extinctions
EAFFI	GO:0008566	mitochondrial protein-transporting ATPase activity	Extinctions
EAFFI	GO:0008374	O-acyltransferase activity	Extinctions
EAFFI	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
EAFFI	GO:0004095	carnitine O-palmitoyltransferase activity	Extinctions
EAFFI	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
EAFFI	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	Extinctions
EAFFI	GO:0016454	C-palmitoyltransferase activity	Extinctions
EAFFI	GO:0004758	serine C-palmitoyltransferase activity	Extinctions
EAFFI	GO:0016416	O-palmitoyltransferase activity	Extinctions
EAFFI	GO:0016406	carnitine O-acyltransferase activity	Extinctions
EAFFI	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Extinctions
EAFFI	GO:0004935	adrenergic receptor activity	Extinctions
EAFFI	GO:0004806	triglyceride lipase activity	Extinctions
EAFFI	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Extinctions
EAFFI	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Extinctions
EAFFI	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Extinctions
EAFFI	GO:0003913	DNA photolyase activity	Extinctions
EAFFI	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Extinctions
EAFFI	GO:0008171	O-methyltransferase activity	Extinctions
EAFFI	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Extinctions
EAFFI	GO:0004143	diacylglycerol kinase activity	Extinctions
MQUAD	GO:0003964	RNA-directed DNA polymerase activity	Gains
MQUAD	GO:0034061	DNA polymerase activity	Gains
MQUAD	GO:0016779	nucleotidyltransferase activity	Gains
MQUAD	GO:0005244	voltage-gated ion channel activity	Gains
MQUAD	GO:0022832	voltage-gated channel activity	Gains
MQUAD	GO:0022843	voltage-gated cation channel activity	Gains
MQUAD	GO:0008528	G-protein coupled peptide receptor activity	Gains
MQUAD	GO:0099600	transmembrane receptor activity	Gains
MQUAD	GO:0001653	peptide receptor activity	Gains
MQUAD	GO:0005249	voltage-gated potassium channel activity	Gains
MQUAD	GO:0022836	gated channel activity	Gains
MQUAD	GO:0140097	catalytic activity, acting on DNA	Gains
MQUAD	GO:0004872	receptor activity	Gains
MQUAD	GO:0060089	molecular transducer activity	Gains
MQUAD	GO:0038023	signaling receptor activity	Gains
MQUAD	GO:0004803	transposase activity	Gains
MQUAD	GO:0004930	G-protein coupled receptor activity	Gains
MQUAD	GO:0004190	aspartic-type endopeptidase activity	Gains
MQUAD	GO:0070001	aspartic-type peptidase activity	Gains
MQUAD	GO:0004871	signal transducer activity	Gains
MQUAD	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
MQUAD	GO:0004887	thyroid hormone receptor activity	Gains
MQUAD	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
MQUAD	GO:0015079	potassium ion transmembrane transporter activity	Gains
MQUAD	GO:0005216	ion channel activity	Gains
MQUAD	GO:0004888	transmembrane signaling receptor activity	Gains
MQUAD	GO:0003676	nucleic acid binding	Gains
MQUAD	GO:0022838	substrate-specific channel activity	Gains
MQUAD	GO:0005261	cation channel activity	Gains
MQUAD	GO:0005267	potassium channel activity	Gains
MQUAD	GO:0022803	passive transmembrane transporter activity	Gains
MQUAD	GO:0015267	channel activity	Gains
MQUAD	GO:0018685	alkane 1-monooxygenase activity	Gains
MQUAD	GO:0008188	neuropeptide receptor activity	Gains
MQUAD	GO:0004935	adrenergic receptor activity	Gains
MQUAD	GO:0004977	melanocortin receptor activity	Gains
MQUAD	GO:0003677	DNA binding	Gains
MQUAD	GO:0015368	calcium:cation antiporter activity	Gains
MQUAD	GO:0016740	transferase activity	Gains
MQUAD	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
MQUAD	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
MQUAD	GO:0046873	metal ion transmembrane transporter activity	Gains
MQUAD	GO:0003723	RNA binding	Gains
MQUAD	GO:0015035	protein disulfide oxidoreductase activity	Gains
MQUAD	GO:0020037	heme binding	Gains
MQUAD	GO:0003700	DNA binding transcription factor activity	Gains
MQUAD	GO:0015075	ion transmembrane transporter activity	Gains
MQUAD	GO:0046906	tetrapyrrole binding	Gains
MQUAD	GO:0070330	aromatase activity	Gains
MQUAD	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
MQUAD	GO:1901363	heterocyclic compound binding	Gains
MQUAD	GO:0097159	organic cyclic compound binding	Gains
MQUAD	GO:0005549	odorant binding	Losses
MQUAD	GO:0004984	olfactory receptor activity	Losses
MQUAD	GO:0005119	smoothened binding	Losses
MQUAD	GO:0004857	enzyme inhibitor activity	Losses
MQUAD	GO:0030414	peptidase inhibitor activity	Losses
MQUAD	GO:0061134	peptidase regulator activity	Losses
MQUAD	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Losses
MQUAD	GO:0016805	dipeptidase activity	Losses
MQUAD	GO:0005200	structural constituent of cytoskeleton	Losses
MQUAD	GO:0008239	dipeptidyl-peptidase activity	Losses
MQUAD	GO:0001664	G-protein coupled receptor binding	Losses
MQUAD	GO:0038023	signaling receptor activity	Losses
MQUAD	GO:0004930	G-protein coupled receptor activity	Losses
MQUAD	GO:0005484	SNAP receptor activity	Losses
MQUAD	GO:0030145	manganese ion binding	Losses
MQUAD	GO:0048018	receptor ligand activity	Losses
MQUAD	GO:0004866	endopeptidase inhibitor activity	Losses
MQUAD	GO:0004888	transmembrane signaling receptor activity	Losses
MQUAD	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Losses
MQUAD	GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	Losses
MQUAD	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Losses
MQUAD	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Losses
MQUAD	GO:0004734	pyrimidodiazepine synthase activity	Losses
MQUAD	GO:0047886	farnesol dehydrogenase activity	Losses
MQUAD	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Losses
MQUAD	GO:0033897	ribonuclease T2 activity	Losses
MQUAD	GO:0016209	antioxidant activity	Losses
MQUAD	GO:0061135	endopeptidase regulator activity	Losses
MQUAD	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
MQUAD	GO:0008061	chitin binding	Losses
MQUAD	GO:0030545	receptor regulator activity	Losses
MQUAD	GO:0099600	transmembrane receptor activity	Losses
MQUAD	GO:0005198	structural molecule activity	Losses
MQUAD	GO:0042302	structural constituent of cuticle	Losses
MQUAD	GO:0022857	transmembrane transporter activity	Losses
MQUAD	GO:0043492	ATPase activity, coupled to movement of substances	Losses
MQUAD	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
MQUAD	GO:0005214	structural constituent of chitin-based cuticle	Losses
MQUAD	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
MQUAD	GO:0046423	allene-oxide cyclase activity	Losses
MQUAD	GO:0005113	patched binding	Losses
MQUAD	GO:0015088	copper uptake transmembrane transporter activity	Losses
MQUAD	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
MQUAD	GO:0015037	peptide disulfide oxidoreductase activity	Losses
MQUAD	GO:0015038	glutathione disulfide oxidoreductase activity	Losses
MQUAD	GO:0005243	gap junction channel activity	Losses
MQUAD	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
MQUAD	GO:0050824	water binding	Losses
MQUAD	GO:0050825	ice binding	Losses
MQUAD	GO:0019788	NEDD8 transferase activity	Losses
MQUAD	GO:0070594	juvenile hormone response element binding	Losses
MQUAD	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
MQUAD	GO:0008379	thioredoxin peroxidase activity	Losses
MQUAD	GO:0004872	receptor activity	Losses
MQUAD	GO:0005119	smoothened binding	Extinctions
MQUAD	GO:0005549	odorant binding	Extinctions
MQUAD	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Extinctions
MQUAD	GO:0004984	olfactory receptor activity	Extinctions
MQUAD	GO:0001664	G-protein coupled receptor binding	Extinctions
MQUAD	GO:0005484	SNAP receptor activity	Extinctions
MQUAD	GO:0048018	receptor ligand activity	Extinctions
MQUAD	GO:0004857	enzyme inhibitor activity	Extinctions
MQUAD	GO:0030145	manganese ion binding	Extinctions
MQUAD	GO:0030545	receptor regulator activity	Extinctions
MQUAD	GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	Extinctions
MQUAD	GO:0033897	ribonuclease T2 activity	Extinctions
MQUAD	GO:0030414	peptidase inhibitor activity	Extinctions
MQUAD	GO:0061134	peptidase regulator activity	Extinctions
MQUAD	GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
MQUAD	GO:0000149	SNARE binding	Extinctions
MQUAD	GO:0005113	patched binding	Extinctions
MQUAD	GO:0015088	copper uptake transmembrane transporter activity	Extinctions
MQUAD	GO:0004812	aminoacyl-tRNA ligase activity	Extinctions
MQUAD	GO:0019901	protein kinase binding	Extinctions
MQUAD	GO:0004040	amidase activity	Extinctions
MQUAD	GO:0004989	octopamine receptor activity	Extinctions
MQUAD	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Extinctions
MQUAD	GO:0004827	proline-tRNA ligase activity	Extinctions
MQUAD	GO:0004831	tyrosine-tRNA ligase activity	Extinctions
MQUAD	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
MQUAD	GO:0005102	receptor binding	Extinctions
60	GO:0043565	sequence-specific DNA binding	Gains
60	GO:0003700	DNA binding transcription factor activity	Gains
60	GO:0004993	G-protein coupled serotonin receptor activity	Gains
60	GO:0099589	serotonin receptor activity	Gains
60	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
60	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
60	GO:0044212	transcription regulatory region DNA binding	Gains
60	GO:0001067	regulatory region nucleic acid binding	Gains
60	GO:0000975	regulatory region DNA binding	Gains
60	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
60	GO:0140110	transcription regulator activity	Gains
60	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
60	GO:0000976	transcription regulatory region sequence-specific DNA binding	Gains
60	GO:1990837	sequence-specific double-stranded DNA binding	Gains
60	GO:0035049	juvenile hormone acid methyltransferase activity	Gains
60	GO:0047964	glyoxylate reductase activity	Gains
60	GO:0051538	3 iron, 4 sulfur cluster binding	Gains
60	GO:0030267	glyoxylate reductase (NADP) activity	Gains
60	GO:0019010	farnesoic acid O-methyltransferase activity	Gains
60	GO:0008227	G-protein coupled amine receptor activity	Gains
60	GO:0003690	double-stranded DNA binding	Gains
60	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Gains
60	GO:0015183	L-aspartate transmembrane transporter activity	Gains
60	GO:0048039	ubiquinone binding	Gains
60	GO:0015501	glutamate:sodium symporter activity	Gains
60	GO:0004970	ionotropic glutamate receptor activity	Gains
60	GO:0022824	transmitter-gated ion channel activity	Gains
60	GO:0022835	transmitter-gated channel activity	Gains
60	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
60	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
60	GO:0017153	sodium:dicarboxylate symporter activity	Gains
60	GO:0004989	octopamine receptor activity	Gains
60	GO:0004977	melanocortin receptor activity	Gains
60	GO:0004463	leukotriene-A4 hydrolase activity	Gains
60	GO:0030060	L-malate dehydrogenase activity	Gains
60	GO:0005416	cation:amino acid symporter activity	Gains
60	GO:0005283	sodium:amino acid symporter activity	Gains
60	GO:0004617	phosphoglycerate dehydrogenase activity	Gains
60	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
60	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Gains
60	GO:0004000	adenosine deaminase activity	Gains
60	GO:0008066	glutamate receptor activity	Gains
60	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
60	GO:0000104	succinate dehydrogenase activity	Gains
60	GO:0048038	quinone binding	Gains
60	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Gains
60	GO:0030594	neurotransmitter receptor activity	Gains
60	GO:0048037	cofactor binding	Losses
60	GO:0019842	vitamin binding	Losses
60	GO:0015291	secondary active transmembrane transporter activity	Losses
60	GO:0015293	symporter activity	Losses
60	GO:0016841	ammonia-lyase activity	Losses
60	GO:0070279	vitamin B6 binding	Losses
60	GO:0030170	pyridoxal phosphate binding	Losses
60	GO:0042302	structural constituent of cuticle	Losses
60	GO:0008324	cation transmembrane transporter activity	Losses
60	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
60	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Losses
60	GO:0005201	extracellular matrix structural constituent	Losses
60	GO:0005215	transporter activity	Losses
60	GO:0008194	UDP-glycosyltransferase activity	Losses
60	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
60	GO:0015075	ion transmembrane transporter activity	Losses
60	GO:0050662	coenzyme binding	Losses
60	GO:0004745	retinol dehydrogenase activity	Losses
60	GO:0003995	acyl-CoA dehydrogenase activity	Losses
60	GO:0005214	structural constituent of chitin-based cuticle	Losses
60	GO:0016758	transferase activity, transferring hexosyl groups	Losses
60	GO:0016840	carbon-nitrogen lyase activity	Losses
60	GO:0016757	transferase activity, transferring glycosyl groups	Losses
60	GO:0022857	transmembrane transporter activity	Losses
60	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
60	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
60	GO:0004629	phospholipase C activity	Losses
60	GO:0008329	signaling pattern recognition receptor activity	Losses
60	GO:0005178	integrin binding	Losses
60	GO:0038187	pattern recognition receptor activity	Losses
60	GO:0004658	propionyl-CoA carboxylase activity	Losses
60	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Losses
60	GO:0046914	transition metal ion binding	Losses
60	GO:0015294	solute:cation symporter activity	Losses
60	GO:0015081	sodium ion transmembrane transporter activity	Losses
60	GO:0050660	flavin adenine dinucleotide binding	Losses
60	GO:0022892	substrate-specific transporter activity	Losses
60	GO:0016421	CoA carboxylase activity	Losses
60	GO:0003824	catalytic activity	Losses
60	GO:0030976	thiamine pyrophosphate binding	Losses
60	GO:0070001	aspartic-type peptidase activity	Losses
60	GO:0004190	aspartic-type endopeptidase activity	Losses
60	GO:0022891	substrate-specific transmembrane transporter activity	Losses
60	GO:0004519	endonuclease activity	Losses
60	GO:0046872	metal ion binding	Losses
60	GO:0048018	receptor ligand activity	Losses
60	GO:0008146	sulfotransferase activity	Losses
60	GO:0042834	peptidoglycan binding	Losses
60	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
60	GO:0043169	cation binding	Losses
60	GO:0004518	nuclease activity	Losses
60	GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
60	GO:0015002	heme-copper terminal oxidase activity	Losses
60	GO:0008378	galactosyltransferase activity	Losses
60	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
60	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
60	GO:0004129	cytochrome-c oxidase activity	Losses
60	GO:0016782	transferase activity, transferring sulfur-containing groups	Losses
60	GO:0004521	endoribonuclease activity	Losses
60	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Losses
60	GO:0070330	aromatase activity	Losses
60	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
60	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
60	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
60	GO:0046873	metal ion transmembrane transporter activity	Losses
60	GO:0022890	inorganic cation transmembrane transporter activity	Losses
60	GO:0020037	heme binding	Losses
60	GO:0030545	receptor regulator activity	Losses
60	GO:0046906	tetrapyrrole binding	Losses
60	GO:0008061	chitin binding	Losses
60	GO:0047886	farnesol dehydrogenase activity	Losses
60	GO:0004062	aryl sulfotransferase activity	Losses
60	GO:0004027	alcohol sulfotransferase activity	Losses
60	GO:0004038	allantoinase activity	Losses
60	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Losses
60	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Losses
60	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Losses
60	GO:0097005	adipokinetic hormone receptor binding	Losses
60	GO:0004397	histidine ammonia-lyase activity	Losses
60	GO:0050480	imidazolonepropionase activity	Losses
60	GO:0004304	estrone sulfotransferase activity	Losses
60	GO:0003726	double-stranded RNA adenosine deaminase activity	Losses
60	GO:0051428	peptide hormone receptor binding	Losses
60	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
60	GO:0019113	limonene monooxygenase activity	Losses
60	GO:0016019	peptidoglycan receptor activity	Losses
60	GO:0050188	phosphoenolpyruvate mutase activity	Losses
60	GO:0003825	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	Losses
60	GO:0032500	muramyl dipeptide binding	Losses
60	GO:0004157	dihydropyrimidinase activity	Losses
60	GO:0097493	structural molecule activity conferring elasticity	Losses
60	GO:0005219	ryanodine-sensitive calcium-release channel activity	Losses
60	GO:0008810	cellulase activity	Losses
60	GO:0050897	cobalt ion binding	Losses
60	GO:0008511	sodium:potassium:chloride symporter activity	Losses
60	GO:0047304	2-aminoethylphosphonate-pyruvate transaminase activity	Losses
60	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Losses
60	GO:0050840	extracellular matrix binding	Losses
60	GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity	Losses
60	GO:0004802	transketolase activity	Losses
60	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Losses
60	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Losses
60	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
60	GO:0004566	beta-glucuronidase activity	Losses
60	GO:0004556	alpha-amylase activity	Losses
60	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
60	GO:0042768	ecdysteroid 2-hydroxylase activity	Losses
60	GO:0016160	amylase activity	Losses
60	GO:0004528	phosphodiesterase I activity	Losses
60	GO:0016153	urocanate hydratase activity	Losses
60	GO:0005542	folic acid binding	Losses
60	GO:0003984	acetolactate synthase activity	Losses
60	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
60	GO:0003941	L-serine ammonia-lyase activity	Losses
60	GO:0001875	lipopolysaccharide receptor activity	Losses
60	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
60	GO:0008031	eclosion hormone activity	Losses
60	GO:0052870	tocopherol omega-hydroxylase activity	Losses
60	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
60	GO:0034584	piRNA binding	Losses
60	GO:0035529	NADH pyrophosphatase activity	Losses
60	GO:0033980	phosphonopyruvate decarboxylase activity	Losses
60	GO:0033981	D-dopachrome decarboxylase activity	Losses
60	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
60	GO:0008395	steroid hydroxylase activity	Losses
60	GO:0015296	anion:cation symporter activity	Losses
60	GO:0030165	PDZ domain binding	Losses
60	GO:0003960	NADPH:quinone reductase activity	Losses
60	GO:0005179	hormone activity	Losses
60	GO:0008270	zinc ion binding	Losses
60	GO:0004970	ionotropic glutamate receptor activity	Novel expansions
60	GO:0022824	transmitter-gated ion channel activity	Novel expansions
60	GO:0022835	transmitter-gated channel activity	Novel expansions
60	GO:0005234	extracellularly glutamate-gated ion channel activity	Novel expansions
60	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Novel expansions
60	GO:0008066	glutamate receptor activity	Novel expansions
60	GO:0030594	neurotransmitter receptor activity	Novel expansions
60	GO:0030695	GTPase regulator activity	Novel expansions
60	GO:0060589	nucleoside-triphosphatase regulator activity	Novel expansions
60	GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
60	GO:0016841	ammonia-lyase activity	Extinctions
60	GO:0019842	vitamin binding	Extinctions
60	GO:0016840	carbon-nitrogen lyase activity	Extinctions
60	GO:0004658	propionyl-CoA carboxylase activity	Extinctions
60	GO:0048037	cofactor binding	Extinctions
60	GO:0030976	thiamine pyrophosphate binding	Extinctions
60	GO:0015002	heme-copper terminal oxidase activity	Extinctions
60	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
60	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
60	GO:0004129	cytochrome-c oxidase activity	Extinctions
60	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
60	GO:0070279	vitamin B6 binding	Extinctions
60	GO:0030170	pyridoxal phosphate binding	Extinctions
60	GO:0003960	NADPH:quinone reductase activity	Extinctions
60	GO:0004038	allantoinase activity	Extinctions
60	GO:0097005	adipokinetic hormone receptor binding	Extinctions
60	GO:0004397	histidine ammonia-lyase activity	Extinctions
60	GO:0050480	imidazolonepropionase activity	Extinctions
60	GO:0051428	peptide hormone receptor binding	Extinctions
60	GO:0050188	phosphoenolpyruvate mutase activity	Extinctions
60	GO:0050897	cobalt ion binding	Extinctions
60	GO:0047304	2-aminoethylphosphonate-pyruvate transaminase activity	Extinctions
60	GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity	Extinctions
60	GO:0016153	urocanate hydratase activity	Extinctions
60	GO:0005542	folic acid binding	Extinctions
60	GO:0003984	acetolactate synthase activity	Extinctions
60	GO:0003941	L-serine ammonia-lyase activity	Extinctions
60	GO:0033980	phosphonopyruvate decarboxylase activity	Extinctions
60	GO:0033981	D-dopachrome decarboxylase activity	Extinctions
60	GO:0004435	phosphatidylinositol phospholipase C activity	Extinctions
60	GO:0004629	phospholipase C activity	Extinctions
60	GO:0016782	transferase activity, transferring sulfur-containing groups	Extinctions
60	GO:0016421	CoA carboxylase activity	Extinctions
60	GO:0016829	lyase activity	Extinctions
60	GO:0016790	thiolester hydrolase activity	Extinctions
60	GO:1901681	sulfur compound binding	Extinctions
60	GO:0031071	cysteine desulfurase activity	Extinctions
60	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Extinctions
60	GO:0004760	serine-pyruvate transaminase activity	Extinctions
61	GO:0005549	odorant binding	Gains
61	GO:0004984	olfactory receptor activity	Gains
61	GO:0004888	transmembrane signaling receptor activity	Gains
61	GO:0038023	signaling receptor activity	Gains
61	GO:0004970	ionotropic glutamate receptor activity	Gains
61	GO:0022824	transmitter-gated ion channel activity	Gains
61	GO:0022835	transmitter-gated channel activity	Gains
61	GO:0099600	transmembrane receptor activity	Gains
61	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
61	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
61	GO:0008066	glutamate receptor activity	Gains
61	GO:0030594	neurotransmitter receptor activity	Gains
61	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
61	GO:0004872	receptor activity	Gains
61	GO:0060089	molecular transducer activity	Gains
61	GO:0004871	signal transducer activity	Gains
61	GO:0005230	extracellular ligand-gated ion channel activity	Gains
61	GO:0008527	taste receptor activity	Gains
61	GO:0015276	ligand-gated ion channel activity	Gains
61	GO:0022834	ligand-gated channel activity	Gains
61	GO:0022857	transmembrane transporter activity	Gains
61	GO:0004497	monooxygenase activity	Gains
61	GO:0005216	ion channel activity	Gains
61	GO:0022838	substrate-specific channel activity	Gains
61	GO:0015267	channel activity	Gains
61	GO:0022803	passive transmembrane transporter activity	Gains
61	GO:0009703	nitrate reductase (NADH) activity	Gains
61	GO:0097109	neuroligin family protein binding	Gains
61	GO:0045735	nutrient reservoir activity	Gains
61	GO:0004507	steroid 11-beta-monooxygenase activity	Gains
61	GO:0008940	nitrate reductase activity	Gains
61	GO:0034185	apolipoprotein binding	Gains
61	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
61	GO:0001093	TFIIB-class transcription factor binding	Gains
61	GO:0070735	protein-glycine ligase activity	Gains
61	GO:0070736	protein-glycine ligase activity, initiating	Gains
61	GO:0070737	protein-glycine ligase activity, elongating	Gains
61	GO:0008473	ornithine cyclodeaminase activity	Gains
61	GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
61	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Gains
61	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
61	GO:0022836	gated channel activity	Gains
61	GO:0005215	transporter activity	Gains
61	GO:0004930	G-protein coupled receptor activity	Gains
61	GO:0022891	substrate-specific transmembrane transporter activity	Gains
61	GO:0004371	glycerone kinase activity	Gains
61	GO:0033041	sweet taste receptor activity	Gains
61	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
61	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
61	GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
61	GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
61	GO:0052834	inositol monophosphate phosphatase activity	Gains
61	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
61	GO:0015927	trehalase activity	Gains
61	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
61	GO:0004555	alpha,alpha-trehalase activity	Gains
61	GO:0004503	monophenol monooxygenase activity	Gains
61	GO:0016084	myostimulatory hormone activity	Gains
61	GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
61	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
61	GO:0001092	TFIIA-class transcription factor binding	Gains
61	GO:0004806	triglyceride lipase activity	Gains
61	GO:0020037	heme binding	Gains
61	GO:0046906	tetrapyrrole binding	Gains
61	GO:0005216	ion channel activity	Losses
61	GO:0022838	substrate-specific channel activity	Losses
61	GO:0015267	channel activity	Losses
61	GO:0022803	passive transmembrane transporter activity	Losses
61	GO:0046873	metal ion transmembrane transporter activity	Losses
61	GO:0099600	transmembrane receptor activity	Losses
61	GO:0015075	ion transmembrane transporter activity	Losses
61	GO:0004871	signal transducer activity	Losses
61	GO:0005261	cation channel activity	Losses
61	GO:0022836	gated channel activity	Losses
61	GO:0004872	receptor activity	Losses
61	GO:0060089	molecular transducer activity	Losses
61	GO:0022843	voltage-gated cation channel activity	Losses
61	GO:0038023	signaling receptor activity	Losses
61	GO:0004888	transmembrane signaling receptor activity	Losses
61	GO:0008324	cation transmembrane transporter activity	Losses
61	GO:0022891	substrate-specific transmembrane transporter activity	Losses
61	GO:0022890	inorganic cation transmembrane transporter activity	Losses
61	GO:0022857	transmembrane transporter activity	Losses
61	GO:0022892	substrate-specific transporter activity	Losses
61	GO:0005267	potassium channel activity	Losses
61	GO:0005244	voltage-gated ion channel activity	Losses
61	GO:0022832	voltage-gated channel activity	Losses
61	GO:0016502	nucleotide receptor activity	Losses
61	GO:0001614	purinergic nucleotide receptor activity	Losses
61	GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
61	GO:0004983	neuropeptide Y receptor activity	Losses
61	GO:0015079	potassium ion transmembrane transporter activity	Losses
61	GO:0004930	G-protein coupled receptor activity	Losses
61	GO:0016917	GABA receptor activity	Losses
61	GO:0005249	voltage-gated potassium channel activity	Losses
61	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
61	GO:0035586	purinergic receptor activity	Losses
61	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Losses
61	GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
61	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
61	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
61	GO:0004497	monooxygenase activity	Losses
61	GO:0015276	ligand-gated ion channel activity	Losses
61	GO:0022834	ligand-gated channel activity	Losses
61	GO:0045289	luciferin monooxygenase activity	Losses
61	GO:0046982	protein heterodimerization activity	Losses
61	GO:0004518	nuclease activity	Losses
61	GO:0005215	transporter activity	Losses
61	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Losses
61	GO:0008307	structural constituent of muscle	Losses
61	GO:0015370	solute:sodium symporter activity	Losses
61	GO:0015081	sodium ion transmembrane transporter activity	Losses
61	GO:0005343	organic acid:sodium symporter activity	Losses
61	GO:0008017	microtubule binding	Losses
61	GO:0016301	kinase activity	Losses
61	GO:0005328	neurotransmitter:sodium symporter activity	Losses
61	GO:0005245	voltage-gated calcium channel activity	Losses
61	GO:0004965	G-protein coupled GABA receptor activity	Losses
61	GO:0046983	protein dimerization activity	Losses
61	GO:0015631	tubulin binding	Losses
61	GO:0003824	catalytic activity	Losses
61	GO:0008188	neuropeptide receptor activity	Losses
61	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
61	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
61	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Losses
61	GO:0070330	aromatase activity	Losses
61	GO:0003677	DNA binding	Losses
61	GO:0015294	solute:cation symporter activity	Losses
61	GO:0005326	neurotransmitter transporter activity	Losses
61	GO:0015085	calcium ion transmembrane transporter activity	Losses
61	GO:0004362	glutathione-disulfide reductase activity	Losses
61	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	Losses
61	GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	Losses
61	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
61	GO:0004321	fatty-acyl-CoA synthase activity	Losses
61	GO:0034584	piRNA binding	Losses
61	GO:0005329	dopamine transmembrane transporter activity	Losses
61	GO:0070577	lysine-acetylated histone binding	Losses
61	GO:0004454	ketohexokinase activity	Losses
61	GO:0036263	L-DOPA monooxygenase activity	Losses
61	GO:0036264	dopamine monooxygenase activity	Losses
61	GO:0033904	dextranase activity	Losses
61	GO:0045309	protein phosphorylated amino acid binding	Losses
61	GO:0042071	leucokinin receptor activity	Losses
61	GO:0042943	D-amino acid transmembrane transporter activity	Losses
61	GO:0004791	thioredoxin-disulfide reductase activity	Losses
61	GO:0017151	DEAD/H-box RNA helicase binding	Losses
61	GO:0017128	phospholipid scramblase activity	Losses
61	GO:0051011	microtubule minus-end binding	Losses
61	GO:0001784	phosphotyrosine residue binding	Losses
61	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Losses
61	GO:0004516	nicotinate phosphoribosyltransferase activity	Losses
61	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
61	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	Losses
61	GO:0005534	galactose binding	Losses
61	GO:0035381	ATP-gated ion channel activity	Losses
61	GO:0047372	acylglycerol lipase activity	Losses
61	GO:0019113	limonene monooxygenase activity	Losses
61	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
61	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	Losses
61	GO:0050473	arachidonate 15-lipoxygenase activity	Losses
61	GO:0008927	mannonate dehydratase activity	Losses
61	GO:0009045	xylose isomerase activity	Losses
61	GO:0008908	isochorismatase activity	Losses
61	GO:0004097	catechol oxidase activity	Losses
61	GO:0010461	light-activated ion channel activity	Losses
61	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
61	GO:0140033	acetylation-dependent protein binding	Losses
61	GO:0004931	extracellularly ATP-gated cation channel activity	Losses
61	GO:0015277	kainate selective glutamate receptor activity	Losses
61	GO:0005003	ephrin receptor activity	Losses
61	GO:0015222	serotonin transmembrane transporter activity	Losses
61	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
61	GO:0019811	cocaine binding	Losses
61	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	Losses
61	GO:0016443	bidentate ribonuclease III activity	Losses
61	GO:0106017	phosphatidylinositol-3,4-bisphosphate phosphatase activity	Losses
61	GO:0005262	calcium channel activity	Losses
61	GO:0008528	G-protein coupled peptide receptor activity	Losses
61	GO:0004713	protein tyrosine kinase activity	Losses
61	GO:0001653	peptide receptor activity	Losses
61	GO:0051213	dioxygenase activity	Losses
61	GO:0008144	drug binding	Losses
61	GO:0099094	ligand-gated cation channel activity	Losses
61	GO:0003993	acid phosphatase activity	Losses
61	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
61	GO:0015293	symporter activity	Losses
61	GO:0005230	extracellular ligand-gated ion channel activity	Losses
61	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
61	GO:0015291	secondary active transmembrane transporter activity	Losses
61	GO:0005549	odorant binding	Novel expansions
61	GO:0046914	transition metal ion binding	Novel expansions
61	GO:0046872	metal ion binding	Novel expansions
61	GO:0043169	cation binding	Novel expansions
61	GO:0008270	zinc ion binding	Novel expansions
61	GO:0004507	steroid 11-beta-monooxygenase activity	Novel expansions
61	GO:0047749	cholestanetriol 26-monooxygenase activity	Novel expansions
61	GO:0022857	transmembrane transporter activity	Novel expansions
61	GO:0005215	transporter activity	Novel expansions
61	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Novel expansions
61	GO:0036081	extracellular ammonia-gated ion channel activity	Novel expansions
61	GO:0008395	steroid hydroxylase activity	Novel expansions
61	GO:0016502	nucleotide receptor activity	Extinctions
61	GO:0001614	purinergic nucleotide receptor activity	Extinctions
61	GO:0035586	purinergic receptor activity	Extinctions
61	GO:0005216	ion channel activity	Extinctions
61	GO:0022838	substrate-specific channel activity	Extinctions
61	GO:0015075	ion transmembrane transporter activity	Extinctions
61	GO:0015267	channel activity	Extinctions
61	GO:0022803	passive transmembrane transporter activity	Extinctions
61	GO:0022891	substrate-specific transmembrane transporter activity	Extinctions
61	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Extinctions
61	GO:0022892	substrate-specific transporter activity	Extinctions
61	GO:0004454	ketohexokinase activity	Extinctions
61	GO:0035381	ATP-gated ion channel activity	Extinctions
61	GO:0047372	acylglycerol lipase activity	Extinctions
61	GO:0050473	arachidonate 15-lipoxygenase activity	Extinctions
61	GO:0008927	mannonate dehydratase activity	Extinctions
61	GO:0009045	xylose isomerase activity	Extinctions
61	GO:0004931	extracellularly ATP-gated cation channel activity	Extinctions
61	GO:0022857	transmembrane transporter activity	Extinctions
61	GO:0004983	neuropeptide Y receptor activity	Extinctions
61	GO:0005261	cation channel activity	Extinctions
61	GO:0008324	cation transmembrane transporter activity	Extinctions
61	GO:0003834	beta-carotene 15,15'-monooxygenase activity	Extinctions
61	GO:0015054	gastrin receptor activity	Extinctions
61	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Extinctions
61	GO:0046873	metal ion transmembrane transporter activity	Extinctions
61	GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
61	GO:0099600	transmembrane receptor activity	Extinctions
61	GO:0008140	cAMP response element binding protein binding	Extinctions
61	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Extinctions
61	GO:0004565	beta-galactosidase activity	Extinctions
61	GO:0004657	proline dehydrogenase activity	Extinctions
61	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Extinctions
61	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Extinctions
61	GO:0004035	alkaline phosphatase activity	Extinctions
61	GO:0017040	ceramidase activity	Extinctions
61	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Extinctions
61	GO:0038023	signaling receptor activity	Extinctions
61	GO:0005432	calcium:sodium antiporter activity	Extinctions
61	GO:0015925	galactosidase activity	Extinctions
62	GO:0003964	RNA-directed DNA polymerase activity	Gains
62	GO:0034061	DNA polymerase activity	Gains
62	GO:0005549	odorant binding	Gains
62	GO:0016779	nucleotidyltransferase activity	Gains
62	GO:0003990	acetylcholinesterase activity	Gains
62	GO:0004104	cholinesterase activity	Gains
62	GO:0022857	transmembrane transporter activity	Gains
62	GO:0005215	transporter activity	Gains
62	GO:0015114	phosphate ion transmembrane transporter activity	Gains
62	GO:1901677	phosphate transmembrane transporter activity	Gains
62	GO:0004344	glucose dehydrogenase activity	Gains
62	GO:0008812	choline dehydrogenase activity	Gains
62	GO:0015926	glucosidase activity	Gains
62	GO:0140097	catalytic activity, acting on DNA	Gains
62	GO:0004857	enzyme inhibitor activity	Gains
62	GO:0015103	inorganic anion transmembrane transporter activity	Gains
62	GO:0050824	water binding	Gains
62	GO:0050825	ice binding	Gains
62	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Gains
62	GO:0008447	L-ascorbate oxidase activity	Gains
62	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	Gains
62	GO:0019992	diacylglycerol binding	Gains
62	GO:0032450	maltose alpha-glucosidase activity	Gains
62	GO:0090599	alpha-glucosidase activity	Gains
62	GO:0046914	transition metal ion binding	Gains
62	GO:0008329	signaling pattern recognition receptor activity	Gains
62	GO:0015232	heme transporter activity	Gains
62	GO:0038187	pattern recognition receptor activity	Gains
62	GO:0005501	retinoid binding	Gains
62	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
62	GO:0004549	tRNA-specific ribonuclease activity	Gains
62	GO:0004984	olfactory receptor activity	Gains
62	GO:0042302	structural constituent of cuticle	Gains
62	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
62	GO:0008270	zinc ion binding	Gains
62	GO:0004519	endonuclease activity	Gains
62	GO:0004930	G-protein coupled receptor activity	Gains
62	GO:0015293	symporter activity	Gains
62	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Gains
62	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
62	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
62	GO:0030291	protein serine/threonine kinase inhibitor activity	Gains
62	GO:0022803	passive transmembrane transporter activity	Losses
62	GO:0015267	channel activity	Losses
62	GO:0005215	transporter activity	Losses
62	GO:0005216	ion channel activity	Losses
62	GO:0022838	substrate-specific channel activity	Losses
62	GO:0022857	transmembrane transporter activity	Losses
62	GO:0004560	alpha-L-fucosidase activity	Losses
62	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Losses
62	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Losses
62	GO:0015928	fucosidase activity	Losses
62	GO:0005261	cation channel activity	Losses
62	GO:0004457	lactate dehydrogenase activity	Losses
62	GO:0031419	cobalamin binding	Losses
62	GO:0038023	signaling receptor activity	Losses
62	GO:0022891	substrate-specific transmembrane transporter activity	Losses
62	GO:0030246	carbohydrate binding	Losses
62	GO:0004930	G-protein coupled receptor activity	Losses
62	GO:0016015	morphogen activity	Losses
62	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Losses
62	GO:0005251	delayed rectifier potassium channel activity	Losses
62	GO:0003995	acyl-CoA dehydrogenase activity	Losses
62	GO:0015075	ion transmembrane transporter activity	Losses
62	GO:0016491	oxidoreductase activity	Losses
62	GO:0004888	transmembrane signaling receptor activity	Losses
62	GO:0005267	potassium channel activity	Losses
62	GO:0008083	growth factor activity	Losses
62	GO:0022892	substrate-specific transporter activity	Losses
62	GO:0004467	long-chain fatty acid-CoA ligase activity	Losses
62	GO:0015645	fatty acid ligase activity	Losses
62	GO:0015103	inorganic anion transmembrane transporter activity	Losses
62	GO:0004872	receptor activity	Losses
62	GO:0015079	potassium ion transmembrane transporter activity	Losses
62	GO:0003697	single-stranded DNA binding	Losses
62	GO:0099600	transmembrane receptor activity	Losses
62	GO:0008172	S-methyltransferase activity	Losses
62	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Losses
62	GO:0051213	dioxygenase activity	Losses
62	GO:0008484	sulfuric ester hydrolase activity	Losses
62	GO:0008417	fucosyltransferase activity	Losses
62	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
62	GO:0005121	Toll binding	Losses
62	GO:0005249	voltage-gated potassium channel activity	Losses
62	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Losses
62	GO:0047548	2-methyleneglutarate mutase activity	Losses
62	GO:0010385	double-stranded methylated DNA binding	Losses
62	GO:0106050	tRNA 2'-O-methyltransferase activity	Losses
62	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Losses
62	GO:0008459	chondroitin 6-sulfotransferase activity	Losses
62	GO:0015322	secondary active oligopeptide transmembrane transporter activity	Losses
62	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	Losses
62	GO:0004334	fumarylacetoacetase activity	Losses
62	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
62	GO:0004493	methylmalonyl-CoA epimerase activity	Losses
62	GO:0004494	methylmalonyl-CoA mutase activity	Losses
62	GO:0008196	vitellogenin receptor activity	Losses
62	GO:0042943	D-amino acid transmembrane transporter activity	Losses
62	GO:0004459	L-lactate dehydrogenase activity	Losses
62	GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity	Losses
62	GO:0032183	SUMO binding	Losses
62	GO:0005329	dopamine transmembrane transporter activity	Losses
62	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
62	GO:0015142	tricarboxylic acid transmembrane transporter activity	Losses
62	GO:0015137	citrate transmembrane transporter activity	Losses
62	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity	Losses
62	GO:0015222	serotonin transmembrane transporter activity	Losses
62	GO:0008705	methionine synthase activity	Losses
62	GO:0005125	cytokine activity	Losses
62	GO:0000293	ferric-chelate reductase activity	Losses
62	GO:0004773	steryl-sulfatase activity	Losses
62	GO:0019811	cocaine binding	Losses
62	GO:0008833	deoxyribonuclease IV (phage-T4-induced) activity	Losses
62	GO:0008836	diaminopimelate decarboxylase activity	Losses
62	GO:0008802	betaine-aldehyde dehydrogenase activity	Losses
62	GO:0005225	volume-sensitive anion channel activity	Losses
62	GO:0052813	phosphatidylinositol bisphosphate kinase activity	Losses
62	GO:0008579	JUN kinase phosphatase activity	Losses
62	GO:0008511	sodium:potassium:chloride symporter activity	Losses
62	GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Losses
62	GO:0047341	fucose-1-phosphate guanylyltransferase activity	Losses
62	GO:0004586	ornithine decarboxylase activity	Losses
62	GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	Losses
62	GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Losses
62	GO:0003911	DNA ligase (NAD+) activity	Losses
62	GO:0033735	aspartate dehydrogenase activity	Losses
62	GO:0072320	volume-sensitive chloride channel activity	Losses
62	GO:0047150	betaine-homocysteine S-methyltransferase activity	Losses
62	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Losses
62	GO:0030429	kynureninase activity	Losses
62	GO:0042806	fucose binding	Losses
62	GO:0016595	glutamate binding	Losses
62	GO:0016524	latrotoxin receptor activity	Losses
62	GO:0001642	group III metabotropic glutamate receptor activity	Losses
62	GO:0004960	thromboxane receptor activity	Losses
62	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
62	GO:0004953	icosanoid receptor activity	Losses
62	GO:0004954	prostanoid receptor activity	Losses
62	GO:0004955	prostaglandin receptor activity	Losses
62	GO:0004957	prostaglandin E receptor activity	Losses
62	GO:0050291	sphingosine N-acyltransferase activity	Losses
62	GO:0009020	tRNA (guanosine-2'-O-)-methyltransferase activity	Losses
62	GO:0004936	alpha-adrenergic receptor activity	Losses
62	GO:0004937	alpha1-adrenergic receptor activity	Losses
62	GO:0015291	secondary active transmembrane transporter activity	Losses
62	GO:0060089	molecular transducer activity	Losses
62	GO:0016886	ligase activity, forming phosphoric ester bonds	Losses
62	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Losses
62	GO:0004344	glucose dehydrogenase activity	Novel expansions
62	GO:0008812	choline dehydrogenase activity	Novel expansions
62	GO:0016084	myostimulatory hormone activity	Novel expansions
62	GO:0005550	pheromone binding	Novel expansions
62	GO:0008084	imaginal disc growth factor receptor binding	Novel expansions
62	GO:0005549	odorant binding	Novel expansions
62	GO:0046914	transition metal ion binding	Novel expansions
62	GO:0008447	L-ascorbate oxidase activity	Novel expansions
62	GO:0004768	stearoyl-CoA 9-desaturase activity	Novel expansions
62	GO:0016215	acyl-CoA desaturase activity	Novel expansions
62	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Novel expansions
62	GO:0003964	RNA-directed DNA polymerase activity	Novel expansions
62	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Novel expansions
62	GO:0004930	G-protein coupled receptor activity	Extinctions
62	GO:0031419	cobalamin binding	Extinctions
62	GO:0003995	acyl-CoA dehydrogenase activity	Extinctions
62	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Extinctions
62	GO:0051213	dioxygenase activity	Extinctions
62	GO:0004888	transmembrane signaling receptor activity	Extinctions
62	GO:0008172	S-methyltransferase activity	Extinctions
62	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Extinctions
62	GO:0099600	transmembrane receptor activity	Extinctions
62	GO:0008484	sulfuric ester hydrolase activity	Extinctions
62	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Extinctions
62	GO:0016491	oxidoreductase activity	Extinctions
62	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
62	GO:0038023	signaling receptor activity	Extinctions
62	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Extinctions
62	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Extinctions
62	GO:0047548	2-methyleneglutarate mutase activity	Extinctions
62	GO:0106050	tRNA 2'-O-methyltransferase activity	Extinctions
62	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	Extinctions
62	GO:0004493	methylmalonyl-CoA epimerase activity	Extinctions
62	GO:0004494	methylmalonyl-CoA mutase activity	Extinctions
62	GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity	Extinctions
62	GO:0032183	SUMO binding	Extinctions
62	GO:0008705	methionine synthase activity	Extinctions
62	GO:0004773	steryl-sulfatase activity	Extinctions
62	GO:0008833	deoxyribonuclease IV (phage-T4-induced) activity	Extinctions
62	GO:0008802	betaine-aldehyde dehydrogenase activity	Extinctions
62	GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Extinctions
62	GO:0047341	fucose-1-phosphate guanylyltransferase activity	Extinctions
62	GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	Extinctions
62	GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Extinctions
62	GO:0033735	aspartate dehydrogenase activity	Extinctions
62	GO:0047150	betaine-homocysteine S-methyltransferase activity	Extinctions
62	GO:0030429	kynureninase activity	Extinctions
62	GO:0016595	glutamate binding	Extinctions
62	GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
62	GO:0004960	thromboxane receptor activity	Extinctions
62	GO:0004953	icosanoid receptor activity	Extinctions
62	GO:0004954	prostanoid receptor activity	Extinctions
62	GO:0004955	prostaglandin receptor activity	Extinctions
62	GO:0004957	prostaglandin E receptor activity	Extinctions
62	GO:0009020	tRNA (guanosine-2'-O-)-methyltransferase activity	Extinctions
62	GO:0004936	alpha-adrenergic receptor activity	Extinctions
62	GO:0004937	alpha1-adrenergic receptor activity	Extinctions
62	GO:0050660	flavin adenine dinucleotide binding	Extinctions
62	GO:0008175	tRNA methyltransferase activity	Extinctions
62	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Extinctions
62	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
62	GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
62	GO:0008445	D-aspartate oxidase activity	Extinctions
62	GO:0004458	D-lactate dehydrogenase (cytochrome) activity	Extinctions
62	GO:0015459	potassium channel regulator activity	Extinctions
62	GO:0015485	cholesterol binding	Extinctions
62	GO:0030696	tRNA (m5U54) methyltransferase activity	Extinctions
62	GO:0030697	S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity	Extinctions
62	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity	Extinctions
62	GO:0003884	D-amino-acid oxidase activity	Extinctions
62	GO:0016300	tRNA (uracil) methyltransferase activity	Extinctions
62	GO:0016208	AMP binding	Extinctions
62	GO:0016898	oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	Extinctions
62	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Extinctions
62	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Extinctions
62	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
62	GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
62	GO:0015922	aspartate oxidase activity	Extinctions
62	GO:0004872	receptor activity	Extinctions
62	GO:0019842	vitamin binding	Extinctions
63	GO:0060089	molecular transducer activity	Gains
63	GO:0004872	receptor activity	Gains
63	GO:0099600	transmembrane receptor activity	Gains
63	GO:0004930	G-protein coupled receptor activity	Gains
63	GO:0022843	voltage-gated cation channel activity	Gains
63	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
63	GO:0070883	pre-miRNA binding	Gains
63	GO:0070594	juvenile hormone response element binding	Gains
63	GO:0005242	inward rectifier potassium channel activity	Gains
63	GO:0004503	monophenol monooxygenase activity	Gains
63	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
63	GO:0022836	gated channel activity	Gains
63	GO:0005261	cation channel activity	Gains
63	GO:0005267	potassium channel activity	Gains
63	GO:0016740	transferase activity	Gains
63	GO:0005244	voltage-gated ion channel activity	Gains
63	GO:0022832	voltage-gated channel activity	Gains
63	GO:0005216	ion channel activity	Gains
63	GO:0022838	substrate-specific channel activity	Gains
63	GO:0004965	G-protein coupled GABA receptor activity	Gains
63	GO:0022803	passive transmembrane transporter activity	Gains
63	GO:0015267	channel activity	Gains
63	GO:0008528	G-protein coupled peptide receptor activity	Gains
63	GO:0005249	voltage-gated potassium channel activity	Gains
63	GO:0001653	peptide receptor activity	Gains
63	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
63	GO:0015079	potassium ion transmembrane transporter activity	Gains
63	GO:0038023	signaling receptor activity	Gains
63	GO:0016917	GABA receptor activity	Gains
63	GO:0050254	rhodopsin kinase activity	Gains
63	GO:0051427	hormone receptor binding	Gains
63	GO:0016406	carnitine O-acyltransferase activity	Gains
63	GO:0022834	ligand-gated channel activity	Gains
63	GO:0015276	ligand-gated ion channel activity	Gains
63	GO:0004888	transmembrane signaling receptor activity	Gains
63	GO:0008188	neuropeptide receptor activity	Gains
63	GO:0005262	calcium channel activity	Gains
63	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
63	GO:0004871	signal transducer activity	Gains
63	GO:0022891	substrate-specific transmembrane transporter activity	Gains
63	GO:0015075	ion transmembrane transporter activity	Gains
63	GO:0022857	transmembrane transporter activity	Gains
63	GO:0003990	acetylcholinesterase activity	Gains
63	GO:0046873	metal ion transmembrane transporter activity	Gains
63	GO:0004983	neuropeptide Y receptor activity	Gains
63	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
63	GO:0004104	cholinesterase activity	Gains
63	GO:0005245	voltage-gated calcium channel activity	Gains
63	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Gains
63	GO:0004692	cGMP-dependent protein kinase activity	Gains
63	GO:0015604	organic phosphonate transmembrane transporter activity	Gains
63	GO:0022892	substrate-specific transporter activity	Gains
63	GO:0016301	kinase activity	Gains
63	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
63	GO:0004935	adrenergic receptor activity	Gains
63	GO:0017151	DEAD/H-box RNA helicase binding	Gains
63	GO:0046790	virion binding	Gains
63	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	Gains
63	GO:0051428	peptide hormone receptor binding	Gains
63	GO:0004791	thioredoxin-disulfide reductase activity	Gains
63	GO:0004796	thromboxane-A synthase activity	Gains
63	GO:0043295	glutathione binding	Gains
63	GO:0019153	protein-disulfide reductase (glutathione) activity	Gains
63	GO:0001222	transcription corepressor binding	Gains
63	GO:0001226	RNA polymerase II transcription corepressor binding	Gains
63	GO:0010461	light-activated ion channel activity	Gains
63	GO:0047886	farnesol dehydrogenase activity	Gains
63	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
63	GO:0004516	nicotinate phosphoribosyltransferase activity	Gains
63	GO:0001784	phosphotyrosine residue binding	Gains
63	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	Gains
63	GO:0036401	pyrokinin receptor activity	Gains
63	GO:0045309	protein phosphorylated amino acid binding	Gains
63	GO:0018833	DDT-dehydrochlorinase activity	Gains
63	GO:0036263	L-DOPA monooxygenase activity	Gains
63	GO:0036264	dopamine monooxygenase activity	Gains
63	GO:0042071	leucokinin receptor activity	Gains
63	GO:0008086	light-activated voltage-gated calcium channel activity	Gains
63	GO:0016499	orexin receptor activity	Gains
63	GO:0016414	O-octanoyltransferase activity	Gains
63	GO:0016443	bidentate ribonuclease III activity	Gains
63	GO:1900750	oligopeptide binding	Gains
63	GO:0004097	catechol oxidase activity	Gains
63	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
63	GO:0097005	adipokinetic hormone receptor binding	Gains
63	GO:0045735	nutrient reservoir activity	Gains
63	GO:0008458	carnitine O-octanoyltransferase activity	Gains
63	GO:0004362	glutathione-disulfide reductase activity	Gains
63	GO:0008447	L-ascorbate oxidase activity	Gains
63	GO:0004497	monooxygenase activity	Gains
63	GO:0003964	RNA-directed DNA polymerase activity	Losses
63	GO:0140097	catalytic activity, acting on DNA	Losses
63	GO:0015081	sodium ion transmembrane transporter activity	Losses
63	GO:0034061	DNA polymerase activity	Losses
63	GO:0004190	aspartic-type endopeptidase activity	Losses
63	GO:0070001	aspartic-type peptidase activity	Losses
63	GO:0001103	RNA polymerase II repressing transcription factor binding	Losses
63	GO:0038023	signaling receptor activity	Losses
63	GO:0004872	receptor activity	Losses
63	GO:0099600	transmembrane receptor activity	Losses
63	GO:0004888	transmembrane signaling receptor activity	Losses
63	GO:0060089	molecular transducer activity	Losses
63	GO:0004871	signal transducer activity	Losses
63	GO:0003700	DNA binding transcription factor activity	Losses
63	GO:0008527	taste receptor activity	Losses
63	GO:0043565	sequence-specific DNA binding	Losses
63	GO:0016787	hydrolase activity	Losses
63	GO:0004930	G-protein coupled receptor activity	Losses
63	GO:0005272	sodium channel activity	Losses
63	GO:0046914	transition metal ion binding	Losses
63	GO:0008270	zinc ion binding	Losses
63	GO:0004984	olfactory receptor activity	Losses
63	GO:0008233	peptidase activity	Losses
63	GO:0008061	chitin binding	Losses
63	GO:0004346	glucose-6-phosphatase activity	Losses
63	GO:0004422	hypoxanthine phosphoribosyltransferase activity	Losses
63	GO:0050309	sugar-terminal-phosphatase activity	Losses
63	GO:0004413	homoserine kinase activity	Losses
63	GO:0015026	coreceptor activity	Losses
63	GO:0005415	nucleoside:sodium symporter activity	Losses
63	GO:0008781	N-acylneuraminate cytidylyltransferase activity	Losses
63	GO:0019113	limonene monooxygenase activity	Losses
63	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
63	GO:0001733	galactosylceramide sulfotransferase activity	Losses
63	GO:0050694	galactose 3-O-sulfotransferase activity	Losses
63	GO:0070976	TIR domain binding	Losses
63	GO:0008068	extracellularly glutamate-gated chloride channel activity	Losses
63	GO:0032183	SUMO binding	Losses
63	GO:0008046	axon guidance receptor activity	Losses
63	GO:0008986	pyruvate, water dikinase activity	Losses
63	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
63	GO:0004055	argininosuccinate synthase activity	Losses
63	GO:0048531	beta-1,3-galactosyltransferase activity	Losses
63	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	Losses
63	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
63	GO:0052657	guanine phosphoribosyltransferase activity	Losses
63	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
63	GO:0008446	GDP-mannose 4,6-dehydratase activity	Losses
63	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
63	GO:0016788	hydrolase activity, acting on ester bonds	Losses
63	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
63	GO:0052745	inositol phosphate phosphatase activity	Losses
63	GO:0016791	phosphatase activity	Losses
63	GO:0042578	phosphoric ester hydrolase activity	Losses
63	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
63	GO:0030247	polysaccharide binding	Losses
63	GO:0001871	pattern binding	Losses
63	GO:0003677	DNA binding	Losses
63	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Losses
63	GO:0004000	adenosine deaminase activity	Losses
63	GO:0051428	peptide hormone receptor binding	Novel expansions
63	GO:0019153	protein-disulfide reductase (glutathione) activity	Novel expansions
63	GO:0097005	adipokinetic hormone receptor binding	Novel expansions
63	GO:0004772	sterol O-acyltransferase activity	Novel expansions
63	GO:0034736	cholesterol O-acyltransferase activity	Novel expansions
63	GO:0016286	small conductance calcium-activated potassium channel activity	Novel expansions
63	GO:0005267	potassium channel activity	Novel expansions
63	GO:0015079	potassium ion transmembrane transporter activity	Novel expansions
63	GO:0008061	chitin binding	Novel expansions
63	GO:0051427	hormone receptor binding	Novel expansions
63	GO:0016630	protochlorophyllide reductase activity	Novel expansions
63	GO:0015269	calcium-activated potassium channel activity	Novel expansions
63	GO:0005227	calcium activated cation channel activity	Novel expansions
63	GO:0022839	ion gated channel activity	Novel expansions
63	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Novel expansions
63	GO:0030165	PDZ domain binding	Novel expansions
63	GO:0004346	glucose-6-phosphatase activity	Extinctions
63	GO:0004422	hypoxanthine phosphoribosyltransferase activity	Extinctions
63	GO:0050309	sugar-terminal-phosphatase activity	Extinctions
63	GO:0004413	homoserine kinase activity	Extinctions
63	GO:0008781	N-acylneuraminate cytidylyltransferase activity	Extinctions
63	GO:0001733	galactosylceramide sulfotransferase activity	Extinctions
63	GO:0050694	galactose 3-O-sulfotransferase activity	Extinctions
63	GO:0004055	argininosuccinate synthase activity	Extinctions
63	GO:0052657	guanine phosphoribosyltransferase activity	Extinctions
63	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
63	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Extinctions
63	GO:0008967	phosphoglycolate phosphatase activity	Extinctions
63	GO:0004997	thyrotropin-releasing hormone receptor activity	Extinctions
63	GO:0043565	sequence-specific DNA binding	Extinctions
63	GO:0004930	G-protein coupled receptor activity	Extinctions
63	GO:0050308	sugar-phosphatase activity	Extinctions
63	GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
63	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
63	GO:0019202	amino acid kinase activity	Extinctions
63	GO:0004686	elongation factor-2 kinase activity	Extinctions
63	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Extinctions
63	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	Extinctions
63	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	Extinctions
63	GO:0016763	transferase activity, transferring pentosyl groups	Extinctions
64	GO:0005216	ion channel activity	Gains
64	GO:0022838	substrate-specific channel activity	Gains
64	GO:0005261	cation channel activity	Gains
64	GO:0015267	channel activity	Gains
64	GO:0022803	passive transmembrane transporter activity	Gains
64	GO:0015075	ion transmembrane transporter activity	Gains
64	GO:0099600	transmembrane receptor activity	Gains
64	GO:0005509	calcium ion binding	Gains
64	GO:0022836	gated channel activity	Gains
64	GO:0008324	cation transmembrane transporter activity	Gains
64	GO:0046873	metal ion transmembrane transporter activity	Gains
64	GO:0004888	transmembrane signaling receptor activity	Gains
64	GO:0022890	inorganic cation transmembrane transporter activity	Gains
64	GO:0022891	substrate-specific transmembrane transporter activity	Gains
64	GO:0022892	substrate-specific transporter activity	Gains
64	GO:0005215	transporter activity	Gains
64	GO:0022857	transmembrane transporter activity	Gains
64	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
64	GO:0022832	voltage-gated channel activity	Gains
64	GO:0005244	voltage-gated ion channel activity	Gains
64	GO:0019199	transmembrane receptor protein kinase activity	Gains
64	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
64	GO:0038023	signaling receptor activity	Gains
64	GO:0003779	actin binding	Gains
64	GO:0004872	receptor activity	Gains
64	GO:0015085	calcium ion transmembrane transporter activity	Gains
64	GO:0004871	signal transducer activity	Gains
64	GO:0005201	extracellular matrix structural constituent	Gains
64	GO:0005230	extracellular ligand-gated ion channel activity	Gains
64	GO:0060089	molecular transducer activity	Gains
64	GO:0005262	calcium channel activity	Gains
64	GO:0015276	ligand-gated ion channel activity	Gains
64	GO:0022834	ligand-gated channel activity	Gains
64	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	Gains
64	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
64	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Gains
64	GO:0022843	voltage-gated cation channel activity	Gains
64	GO:0004972	NMDA glutamate receptor activity	Gains
64	GO:0019992	diacylglycerol binding	Gains
64	GO:0047134	protein-disulfide reductase activity	Gains
64	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	Gains
64	GO:0005267	potassium channel activity	Gains
64	GO:0008061	chitin binding	Gains
64	GO:0008092	cytoskeletal protein binding	Gains
64	GO:0032440	2-alkenal reductase [NAD(P)] activity	Gains
64	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
64	GO:0004713	protein tyrosine kinase activity	Gains
64	GO:0016453	C-acetyltransferase activity	Gains
64	GO:0004447	iodide peroxidase activity	Gains
64	GO:0005154	epidermal growth factor receptor binding	Gains
64	GO:0005248	voltage-gated sodium channel activity	Gains
64	GO:1905030	voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential	Gains
64	GO:0030898	actin-dependent ATPase activity	Gains
64	GO:0099094	ligand-gated cation channel activity	Gains
64	GO:0016491	oxidoreductase activity	Gains
64	GO:0005249	voltage-gated potassium channel activity	Gains
64	GO:0015079	potassium ion transmembrane transporter activity	Gains
64	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
64	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
64	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Gains
64	GO:0070851	growth factor receptor binding	Gains
64	GO:0005251	delayed rectifier potassium channel activity	Gains
64	GO:0017153	sodium:dicarboxylate symporter activity	Gains
64	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
64	GO:0001786	phosphatidylserine binding	Gains
64	GO:0005516	calmodulin binding	Gains
64	GO:0005515	protein binding	Gains
64	GO:0005548	phospholipid transporter activity	Gains
64	GO:0042803	protein homodimerization activity	Gains
64	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
64	GO:0005342	organic acid transmembrane transporter activity	Gains
64	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
64	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
64	GO:0008509	anion transmembrane transporter activity	Gains
64	GO:0072341	modified amino acid binding	Gains
64	GO:0005452	inorganic anion exchanger activity	Gains
64	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
64	GO:0016500	protein-hormone receptor activity	Gains
64	GO:0008188	neuropeptide receptor activity	Gains
64	GO:0050839	cell adhesion molecule binding	Gains
64	GO:0003995	acyl-CoA dehydrogenase activity	Gains
64	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
64	GO:0042802	identical protein binding	Gains
64	GO:0098772	molecular function regulator	Gains
64	GO:0017016	Ras GTPase binding	Gains
64	GO:0016301	kinase activity	Gains
64	GO:0051020	GTPase binding	Gains
64	GO:0043169	cation binding	Gains
64	GO:0003774	motor activity	Gains
64	GO:0031267	small GTPase binding	Gains
64	GO:0008158	hedgehog receptor activity	Gains
64	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
64	GO:0008239	dipeptidyl-peptidase activity	Gains
64	GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
64	GO:0015081	sodium ion transmembrane transporter activity	Gains
64	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
64	GO:0046872	metal ion binding	Gains
64	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
64	GO:0008514	organic anion transmembrane transporter activity	Gains
64	GO:0005179	hormone activity	Losses
64	GO:0048018	receptor ligand activity	Losses
64	GO:0030545	receptor regulator activity	Losses
64	GO:0005184	neuropeptide hormone activity	Losses
64	GO:0016849	phosphorus-oxygen lyase activity	Losses
64	GO:0018685	alkane 1-monooxygenase activity	Losses
64	GO:0003964	RNA-directed DNA polymerase activity	Losses
64	GO:0004930	G-protein coupled receptor activity	Losses
64	GO:0099600	transmembrane receptor activity	Losses
64	GO:0001664	G-protein coupled receptor binding	Losses
64	GO:0004312	fatty acid synthase activity	Losses
64	GO:0046914	transition metal ion binding	Losses
64	GO:0016530	metallochaperone activity	Losses
64	GO:0019238	cyclohydrolase activity	Losses
64	GO:0009922	fatty acid elongase activity	Losses
64	GO:0004518	nuclease activity	Losses
64	GO:0005102	receptor binding	Losses
64	GO:0009975	cyclase activity	Losses
64	GO:0004888	transmembrane signaling receptor activity	Losses
64	GO:0004857	enzyme inhibitor activity	Losses
64	GO:0005506	iron ion binding	Losses
64	GO:0004129	cytochrome-c oxidase activity	Losses
64	GO:0015002	heme-copper terminal oxidase activity	Losses
64	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
64	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
64	GO:0004803	transposase activity	Losses
64	GO:0061134	peptidase regulator activity	Losses
64	GO:0004871	signal transducer activity	Losses
64	GO:0008241	peptidyl-dipeptidase activity	Losses
64	GO:0030291	protein serine/threonine kinase inhibitor activity	Losses
64	GO:0004526	ribonuclease P activity	Losses
64	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
64	GO:0008066	glutamate receptor activity	Losses
64	GO:0038023	signaling receptor activity	Losses
64	GO:0030414	peptidase inhibitor activity	Losses
64	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
64	GO:0005230	extracellular ligand-gated ion channel activity	Losses
64	GO:0004190	aspartic-type endopeptidase activity	Losses
64	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
64	GO:0070001	aspartic-type peptidase activity	Losses
64	GO:0004519	endonuclease activity	Losses
64	GO:0005179	hormone activity	Extinctions
64	GO:0005184	neuropeptide hormone activity	Extinctions
64	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
64	GO:0004930	G-protein coupled receptor activity	Extinctions
64	GO:0099600	transmembrane receptor activity	Extinctions
64	GO:0048018	receptor ligand activity	Extinctions
64	GO:0004888	transmembrane signaling receptor activity	Extinctions
64	GO:0038023	signaling receptor activity	Extinctions
64	GO:0030545	receptor regulator activity	Extinctions
64	GO:0009975	cyclase activity	Extinctions
64	GO:0004872	receptor activity	Extinctions
64	GO:0016530	metallochaperone activity	Extinctions
64	GO:0004129	cytochrome-c oxidase activity	Extinctions
64	GO:0015002	heme-copper terminal oxidase activity	Extinctions
64	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
64	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
64	GO:0060089	molecular transducer activity	Extinctions
64	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
64	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
64	GO:0008066	glutamate receptor activity	Extinctions
64	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
64	GO:0004526	ribonuclease P activity	Extinctions
64	GO:0004521	endoribonuclease activity	Extinctions
64	GO:0004540	ribonuclease activity	Extinctions
64	GO:0004871	signal transducer activity	Extinctions
64	GO:0005506	iron ion binding	Extinctions
64	GO:0008527	taste receptor activity	Extinctions
64	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
64	GO:0061134	peptidase regulator activity	Extinctions
64	GO:0015276	ligand-gated ion channel activity	Extinctions
64	GO:0022834	ligand-gated channel activity	Extinctions
64	GO:0004970	ionotropic glutamate receptor activity	Extinctions
64	GO:0022824	transmitter-gated ion channel activity	Extinctions
64	GO:0022835	transmitter-gated channel activity	Extinctions
64	GO:0004383	guanylate cyclase activity	Extinctions
64	GO:0017147	Wnt-protein binding	Extinctions
64	GO:0004518	nuclease activity	Extinctions
65	GO:0003964	RNA-directed DNA polymerase activity	Gains
65	GO:0034061	DNA polymerase activity	Gains
65	GO:0042302	structural constituent of cuticle	Gains
65	GO:0004872	receptor activity	Gains
65	GO:0140097	catalytic activity, acting on DNA	Gains
65	GO:0008233	peptidase activity	Gains
65	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
65	GO:0008261	allatostatin receptor activity	Gains
65	GO:0030246	carbohydrate binding	Gains
65	GO:0038023	signaling receptor activity	Gains
65	GO:0016779	nucleotidyltransferase activity	Gains
65	GO:0004888	transmembrane signaling receptor activity	Gains
65	GO:0099600	transmembrane receptor activity	Gains
65	GO:0060089	molecular transducer activity	Gains
65	GO:0016491	oxidoreductase activity	Gains
65	GO:0030247	polysaccharide binding	Gains
65	GO:0001871	pattern binding	Gains
65	GO:0004252	serine-type endopeptidase activity	Gains
65	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
65	GO:0004601	peroxidase activity	Gains
65	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
65	GO:0030594	neurotransmitter receptor activity	Gains
65	GO:0005215	transporter activity	Gains
65	GO:0015291	secondary active transmembrane transporter activity	Gains
65	GO:0004518	nuclease activity	Gains
65	GO:0022892	substrate-specific transporter activity	Gains
65	GO:0008237	metallopeptidase activity	Gains
65	GO:0008061	chitin binding	Gains
65	GO:0004175	endopeptidase activity	Gains
65	GO:0003824	catalytic activity	Gains
65	GO:0022824	transmitter-gated ion channel activity	Gains
65	GO:0022835	transmitter-gated channel activity	Gains
65	GO:0004970	ionotropic glutamate receptor activity	Gains
65	GO:0022857	transmembrane transporter activity	Gains
65	GO:0015927	trehalase activity	Gains
65	GO:0004567	beta-mannosidase activity	Gains
65	GO:0004555	alpha,alpha-trehalase activity	Gains
65	GO:0015377	cation:chloride symporter activity	Gains
65	GO:0051032	nucleic acid transmembrane transporter activity	Gains
65	GO:0051033	RNA transmembrane transporter activity	Gains
65	GO:0015198	oligopeptide transporter activity	Gains
65	GO:0035673	oligopeptide transmembrane transporter activity	Gains
65	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
65	GO:0008235	metalloexopeptidase activity	Gains
65	GO:0005201	extracellular matrix structural constituent	Gains
65	GO:0008519	ammonium transmembrane transporter activity	Gains
65	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Gains
65	GO:0022891	substrate-specific transmembrane transporter activity	Gains
65	GO:0140103	catalytic activity, acting on a glycoprotein	Gains
65	GO:0004871	signal transducer activity	Gains
65	GO:0005230	extracellular ligand-gated ion channel activity	Gains
65	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
65	GO:0008066	glutamate receptor activity	Gains
65	GO:0016209	antioxidant activity	Gains
65	GO:0004519	endonuclease activity	Gains
65	GO:0022834	ligand-gated channel activity	Gains
65	GO:0015276	ligand-gated ion channel activity	Gains
65	GO:0020037	heme binding	Gains
65	GO:0005214	structural constituent of chitin-based cuticle	Gains
65	GO:0008236	serine-type peptidase activity	Gains
65	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
65	GO:0016787	hydrolase activity	Gains
65	GO:0017171	serine hydrolase activity	Gains
65	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
65	GO:0008238	exopeptidase activity	Gains
65	GO:0015075	ion transmembrane transporter activity	Gains
65	GO:0046906	tetrapyrrole binding	Gains
65	GO:0015103	inorganic anion transmembrane transporter activity	Gains
65	GO:0015293	symporter activity	Gains
65	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
65	GO:0004806	triglyceride lipase activity	Gains
65	GO:0003913	DNA photolyase activity	Gains
65	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
65	GO:0070001	aspartic-type peptidase activity	Gains
65	GO:0004190	aspartic-type endopeptidase activity	Gains
65	GO:0004984	olfactory receptor activity	Gains
65	GO:0015108	chloride transmembrane transporter activity	Gains
65	GO:0004180	carboxypeptidase activity	Gains
65	GO:0015294	solute:cation symporter activity	Gains
65	GO:0004930	G-protein coupled receptor activity	Gains
65	GO:0015932	nucleobase-containing compound transmembrane transporter activity	Gains
65	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
65	GO:0034450	ubiquitin-ubiquitin ligase activity	Gains
65	GO:0042834	peptidoglycan binding	Gains
65	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
65	GO:0001530	lipopolysaccharide binding	Gains
65	GO:0061659	ubiquitin-like protein ligase activity	Gains
65	GO:0061630	ubiquitin protein ligase activity	Gains
65	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
65	GO:0005506	iron ion binding	Gains
65	GO:0004983	neuropeptide Y receptor activity	Gains
65	GO:0009881	photoreceptor activity	Gains
65	GO:0004602	glutathione peroxidase activity	Gains
65	GO:0004497	monooxygenase activity	Gains
65	GO:0004930	G-protein coupled receptor activity	Losses
65	GO:0003777	microtubule motor activity	Losses
65	GO:0016411	acylglycerol O-acyltransferase activity	Losses
65	GO:0004888	transmembrane signaling receptor activity	Losses
65	GO:0099600	transmembrane receptor activity	Losses
65	GO:0004989	octopamine receptor activity	Losses
65	GO:0004022	alcohol dehydrogenase (NAD) activity	Losses
65	GO:0005509	calcium ion binding	Losses
65	GO:0016630	protochlorophyllide reductase activity	Losses
65	GO:0004144	diacylglycerol O-acyltransferase activity	Losses
65	GO:0038023	signaling receptor activity	Losses
65	GO:0030414	peptidase inhibitor activity	Losses
65	GO:0045296	cadherin binding	Losses
65	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
65	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Losses
65	GO:0035091	phosphatidylinositol binding	Losses
65	GO:0004872	receptor activity	Losses
65	GO:0043169	cation binding	Losses
65	GO:0004993	G-protein coupled serotonin receptor activity	Losses
65	GO:0099589	serotonin receptor activity	Losses
65	GO:0046872	metal ion binding	Losses
65	GO:0061134	peptidase regulator activity	Losses
65	GO:0030165	PDZ domain binding	Losses
65	GO:0004047	aminomethyltransferase activity	Losses
65	GO:0060089	molecular transducer activity	Losses
65	GO:0032403	protein complex binding	Losses
65	GO:0008227	G-protein coupled amine receptor activity	Losses
65	GO:0017151	DEAD/H-box RNA helicase binding	Losses
65	GO:0008609	alkylglycerone-phosphate synthase activity	Losses
65	GO:0003937	IMP cyclohydrolase activity	Losses
65	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Losses
65	GO:0004642	phosphoribosylformylglycinamidine synthase activity	Losses
65	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	Losses
65	GO:0004644	phosphoribosylglycinamide formyltransferase activity	Losses
65	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Losses
65	GO:0004637	phosphoribosylamine-glycine ligase activity	Losses
65	GO:0004638	phosphoribosylaminoimidazole carboxylase activity	Losses
65	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	Losses
65	GO:0031177	phosphopantetheine binding	Losses
65	GO:0005534	galactose binding	Losses
65	GO:0005537	mannose binding	Losses
65	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Losses
65	GO:0008031	eclosion hormone activity	Losses
65	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
65	GO:0016918	retinal binding	Losses
65	GO:0001609	G-protein coupled adenosine receptor activity	Losses
65	GO:0015145	monosaccharide transmembrane transporter activity	Losses
65	GO:0015149	hexose transmembrane transporter activity	Losses
65	GO:0042925	benzoate transmembrane transporter activity	Losses
65	GO:0015250	water channel activity	Losses
65	GO:0005026	transforming growth factor beta receptor activity, type II	Losses
65	GO:0000036	acyl carrier activity	Losses
65	GO:0015217	ADP transmembrane transporter activity	Losses
65	GO:0061604	molybdopterin-synthase sulfurtransferase activity	Losses
65	GO:0061605	molybdopterin-synthase adenylyltransferase activity	Losses
65	GO:0045294	alpha-catenin binding	Losses
65	GO:0050473	arachidonate 15-lipoxygenase activity	Losses
65	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Losses
65	GO:0004371	glycerone kinase activity	Losses
65	GO:0034023	5-(carboxyamino)imidazole ribonucleotide mutase activity	Losses
65	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
65	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
65	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
65	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
65	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
65	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
65	GO:0050111	mycocerosate synthase activity	Losses
65	GO:0050112	inositol 2-dehydrogenase activity	Losses
65	GO:0008191	metalloendopeptidase inhibitor activity	Losses
65	GO:0051192	prosthetic group binding	Losses
65	GO:0005372	water transmembrane transporter activity	Losses
65	GO:0015578	mannose transmembrane transporter activity	Losses
65	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
65	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
65	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
65	GO:0005347	ATP transmembrane transporter activity	Losses
65	GO:0004168	dolichol kinase activity	Losses
65	GO:0044620	ACP phosphopantetheine attachment site binding	Losses
65	GO:0005471	ATP:ADP antiporter activity	Losses
65	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
65	GO:0003774	motor activity	Losses
65	GO:0004857	enzyme inhibitor activity	Losses
65	GO:0004673	protein histidine kinase activity	Novel expansions
65	GO:0000155	phosphorelay sensor kinase activity	Novel expansions
65	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Novel expansions
65	GO:0005201	extracellular matrix structural constituent	Novel expansions
65	GO:0005272	sodium channel activity	Novel expansions
65	GO:0015081	sodium ion transmembrane transporter activity	Novel expansions
65	GO:0004930	G-protein coupled receptor activity	Extinctions
65	GO:0016630	protochlorophyllide reductase activity	Extinctions
65	GO:0004144	diacylglycerol O-acyltransferase activity	Extinctions
65	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Extinctions
65	GO:0004888	transmembrane signaling receptor activity	Extinctions
65	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Extinctions
65	GO:0004047	aminomethyltransferase activity	Extinctions
65	GO:0099600	transmembrane receptor activity	Extinctions
65	GO:0035091	phosphatidylinositol binding	Extinctions
65	GO:0016881	acid-amino acid ligase activity	Extinctions
65	GO:0016411	acylglycerol O-acyltransferase activity	Extinctions
65	GO:0008609	alkylglycerone-phosphate synthase activity	Extinctions
65	GO:0003937	IMP cyclohydrolase activity	Extinctions
65	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Extinctions
65	GO:0004642	phosphoribosylformylglycinamidine synthase activity	Extinctions
65	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	Extinctions
65	GO:0004644	phosphoribosylglycinamide formyltransferase activity	Extinctions
65	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Extinctions
65	GO:0004637	phosphoribosylamine-glycine ligase activity	Extinctions
65	GO:0004638	phosphoribosylaminoimidazole carboxylase activity	Extinctions
65	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	Extinctions
65	GO:0031177	phosphopantetheine binding	Extinctions
65	GO:0005537	mannose binding	Extinctions
65	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Extinctions
65	GO:0016918	retinal binding	Extinctions
65	GO:0001609	G-protein coupled adenosine receptor activity	Extinctions
65	GO:0015145	monosaccharide transmembrane transporter activity	Extinctions
65	GO:0015149	hexose transmembrane transporter activity	Extinctions
65	GO:0042925	benzoate transmembrane transporter activity	Extinctions
65	GO:0000036	acyl carrier activity	Extinctions
65	GO:0050473	arachidonate 15-lipoxygenase activity	Extinctions
65	GO:0004371	glycerone kinase activity	Extinctions
65	GO:0034023	5-(carboxyamino)imidazole ribonucleotide mutase activity	Extinctions
65	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Extinctions
65	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Extinctions
65	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Extinctions
65	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Extinctions
65	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Extinctions
65	GO:0050111	mycocerosate synthase activity	Extinctions
65	GO:0050112	inositol 2-dehydrogenase activity	Extinctions
65	GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
65	GO:0051192	prosthetic group binding	Extinctions
65	GO:0015578	mannose transmembrane transporter activity	Extinctions
65	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Extinctions
65	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Extinctions
65	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Extinctions
65	GO:0004168	dolichol kinase activity	Extinctions
65	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
65	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Extinctions
65	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Extinctions
65	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
66	GO:0004736	pyruvate carboxylase activity	Gains
66	GO:0042302	structural constituent of cuticle	Gains
66	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
66	GO:0017080	sodium channel regulator activity	Gains
66	GO:1990939	ATP-dependent microtubule motor activity	Gains
66	GO:0004075	biotin carboxylase activity	Gains
66	GO:0008417	fucosyltransferase activity	Gains
66	GO:0042826	histone deacetylase binding	Gains
66	GO:0052689	carboxylic ester hydrolase activity	Gains
66	GO:0005214	structural constituent of chitin-based cuticle	Gains
66	GO:0030414	peptidase inhibitor activity	Gains
66	GO:0031208	POZ domain binding	Gains
66	GO:0005215	transporter activity	Gains
66	GO:0004035	alkaline phosphatase activity	Gains
66	GO:0015928	fucosidase activity	Gains
66	GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
66	GO:0005199	structural constituent of cell wall	Gains
66	GO:0004560	alpha-L-fucosidase activity	Gains
66	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
66	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Gains
66	GO:0016885	ligase activity, forming carbon-carbon bonds	Gains
66	GO:0004104	cholinesterase activity	Gains
66	GO:0005227	calcium activated cation channel activity	Gains
66	GO:0061134	peptidase regulator activity	Gains
66	GO:0015294	solute:cation symporter activity	Gains
66	GO:0030246	carbohydrate binding	Gains
66	GO:0003777	microtubule motor activity	Gains
66	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Gains
66	GO:0016247	channel regulator activity	Gains
66	GO:0022839	ion gated channel activity	Gains
66	GO:0004519	endonuclease activity	Gains
66	GO:0016788	hydrolase activity, acting on ester bonds	Gains
66	GO:0005501	retinoid binding	Gains
66	GO:0004064	arylesterase activity	Gains
66	GO:0008336	gamma-butyrobetaine dioxygenase activity	Gains
66	GO:0008198	ferrous iron binding	Gains
66	GO:0004457	lactate dehydrogenase activity	Gains
66	GO:0046592	polyamine oxidase activity	Gains
66	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Gains
66	GO:0019136	deoxynucleoside kinase activity	Gains
66	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Gains
66	GO:0003774	motor activity	Gains
66	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
66	GO:0019206	nucleoside kinase activity	Gains
66	GO:0022836	gated channel activity	Gains
66	GO:0004857	enzyme inhibitor activity	Gains
66	GO:0008233	peptidase activity	Gains
66	GO:0005230	extracellular ligand-gated ion channel activity	Gains
66	GO:0005319	lipid transporter activity	Gains
66	GO:0004866	endopeptidase inhibitor activity	Gains
66	GO:0015293	symporter activity	Gains
66	GO:0004252	serine-type endopeptidase activity	Gains
66	GO:0016886	ligase activity, forming phosphoric ester bonds	Gains
66	GO:0015296	anion:cation symporter activity	Gains
66	GO:0008146	sulfotransferase activity	Gains
66	GO:0003964	RNA-directed DNA polymerase activity	Gains
66	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Gains
66	GO:0004322	ferroxidase activity	Gains
66	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Gains
66	GO:1901677	phosphate transmembrane transporter activity	Gains
66	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
66	GO:0015114	phosphate ion transmembrane transporter activity	Gains
66	GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
66	GO:0038024	cargo receptor activity	Gains
66	GO:0019901	protein kinase binding	Gains
66	GO:0015171	amino acid transmembrane transporter activity	Gains
66	GO:0017171	serine hydrolase activity	Gains
66	GO:0099600	transmembrane receptor activity	Losses
66	GO:0004872	receptor activity	Losses
66	GO:0038023	signaling receptor activity	Losses
66	GO:0060089	molecular transducer activity	Losses
66	GO:0004888	transmembrane signaling receptor activity	Losses
66	GO:0004871	signal transducer activity	Losses
66	GO:0004040	amidase activity	Losses
66	GO:0033041	sweet taste receptor activity	Losses
66	GO:0005539	glycosaminoglycan binding	Losses
66	GO:0004857	enzyme inhibitor activity	Losses
66	GO:0030414	peptidase inhibitor activity	Losses
66	GO:0005216	ion channel activity	Losses
66	GO:0003823	antigen binding	Losses
66	GO:0022838	substrate-specific channel activity	Losses
66	GO:0022803	passive transmembrane transporter activity	Losses
66	GO:0015267	channel activity	Losses
66	GO:0016298	lipase activity	Losses
66	GO:0005509	calcium ion binding	Losses
66	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	Losses
66	GO:0042834	peptidoglycan binding	Losses
66	GO:0008527	taste receptor activity	Losses
66	GO:0061134	peptidase regulator activity	Losses
66	GO:0004866	endopeptidase inhibitor activity	Losses
66	GO:0022834	ligand-gated channel activity	Losses
66	GO:0015276	ligand-gated ion channel activity	Losses
66	GO:0022836	gated channel activity	Losses
66	GO:0061135	endopeptidase regulator activity	Losses
66	GO:0070567	cytidylyltransferase activity	Losses
66	GO:0015081	sodium ion transmembrane transporter activity	Losses
66	GO:0004930	G-protein coupled receptor activity	Losses
66	GO:0004619	phosphoglycerate mutase activity	Losses
66	GO:0016500	protein-hormone receptor activity	Losses
66	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
66	GO:0005230	extracellular ligand-gated ion channel activity	Losses
66	GO:0005272	sodium channel activity	Losses
66	GO:0046873	metal ion transmembrane transporter activity	Losses
66	GO:0008028	monocarboxylic acid transmembrane transporter activity	Losses
66	GO:0008066	glutamate receptor activity	Losses
66	GO:0016788	hydrolase activity, acting on ester bonds	Losses
66	GO:0004620	phospholipase activity	Losses
66	GO:0001875	lipopolysaccharide receptor activity	Losses
66	GO:0019531	oxalate transmembrane transporter activity	Losses
66	GO:0008046	axon guidance receptor activity	Losses
66	GO:0044748	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	Losses
66	GO:0044736	acid-sensing ion channel activity	Losses
66	GO:0016211	ammonia ligase activity	Losses
66	GO:0047022	7-beta-hydroxysteroid dehydrogenase (NADP+) activity	Losses
66	GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	Losses
66	GO:0047035	testosterone dehydrogenase (NAD+) activity	Losses
66	GO:0005007	fibroblast growth factor-activated receptor activity	Losses
66	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
66	GO:0032500	muramyl dipeptide binding	Losses
66	GO:0004396	hexokinase activity	Losses
66	GO:0004356	glutamate-ammonia ligase activity	Losses
66	GO:0004340	glucokinase activity	Losses
66	GO:0004339	glucan 1,4-alpha-glucosidase activity	Losses
66	GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	Losses
66	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
66	GO:0005324	long-chain fatty acid transporter activity	Losses
66	GO:0034185	apolipoprotein binding	Losses
66	GO:0032028	myosin head/neck binding	Losses
66	GO:0097108	hedgehog family protein binding	Losses
66	GO:0097109	neuroligin family protein binding	Losses
66	GO:0031489	myosin V binding	Losses
66	GO:0008865	fructokinase activity	Losses
66	GO:0016019	peptidoglycan receptor activity	Losses
66	GO:0019158	mannokinase activity	Losses
66	GO:0015499	formate transmembrane transporter activity	Losses
66	GO:0070854	myosin VI heavy chain binding	Losses
66	GO:0070855	myosin VI head/neck binding	Losses
66	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	Losses
66	GO:0047747	cholate-CoA ligase activity	Losses
66	GO:0008579	JUN kinase phosphatase activity	Losses
66	GO:0015106	bicarbonate transmembrane transporter activity	Losses
66	GO:0015280	ligand-gated sodium channel activity	Losses
66	GO:0015245	fatty acid transporter activity	Losses
66	GO:0008134	transcription factor binding	Losses
66	GO:0030234	enzyme regulator activity	Losses
66	GO:0003993	acid phosphatase activity	Losses
66	GO:0005261	cation channel activity	Losses
66	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
66	GO:0061783	peptidoglycan muralytic activity	Losses
66	GO:0016868	intramolecular transferase activity, phosphotransferases	Losses
66	GO:0008081	phosphoric diester hydrolase activity	Losses
66	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
66	GO:0005319	lipid transporter activity	Losses
66	GO:0008198	ferrous iron binding	Novel expansions
66	GO:0031208	POZ domain binding	Novel expansions
66	GO:0008199	ferric iron binding	Novel expansions
66	GO:0030414	peptidase inhibitor activity	Novel expansions
66	GO:0004806	triglyceride lipase activity	Novel expansions
66	GO:0004060	arylamine N-acetyltransferase activity	Novel expansions
66	GO:0009045	xylose isomerase activity	Novel expansions
66	GO:0004059	aralkylamine N-acetyltransferase activity	Novel expansions
66	GO:0004038	allantoinase activity	Novel expansions
66	GO:0032813	tumor necrosis factor receptor superfamily binding	Novel expansions
66	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Novel expansions
66	GO:0004392	heme oxygenase (decyclizing) activity	Novel expansions
66	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Novel expansions
66	GO:0005164	tumor necrosis factor receptor binding	Novel expansions
66	GO:0008810	cellulase activity	Novel expansions
66	GO:0004846	urate oxidase activity	Novel expansions
66	GO:0050897	cobalt ion binding	Novel expansions
66	GO:0015204	urea transmembrane transporter activity	Novel expansions
66	GO:0008146	sulfotransferase activity	Novel expansions
66	GO:0061134	peptidase regulator activity	Novel expansions
66	GO:0016860	intramolecular oxidoreductase activity	Novel expansions
66	GO:0015927	trehalase activity	Novel expansions
66	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Novel expansions
66	GO:0005119	smoothened binding	Novel expansions
66	GO:0008704	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	Novel expansions
66	GO:0000210	NAD+ diphosphatase activity	Novel expansions
66	GO:0050220	prostaglandin-E synthase activity	Novel expansions
66	GO:0008526	phosphatidylinositol transporter activity	Novel expansions
66	GO:0004555	alpha,alpha-trehalase activity	Novel expansions
66	GO:0018800	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	Novel expansions
66	GO:0004857	enzyme inhibitor activity	Novel expansions
66	GO:0052689	carboxylic ester hydrolase activity	Novel expansions
66	GO:0017080	sodium channel regulator activity	Novel expansions
66	GO:0015081	sodium ion transmembrane transporter activity	Extinctions
66	GO:0046873	metal ion transmembrane transporter activity	Extinctions
66	GO:0005261	cation channel activity	Extinctions
66	GO:0099600	transmembrane receptor activity	Extinctions
66	GO:0005539	glycosaminoglycan binding	Extinctions
66	GO:0005272	sodium channel activity	Extinctions
66	GO:0004619	phosphoglycerate mutase activity	Extinctions
66	GO:0016500	protein-hormone receptor activity	Extinctions
66	GO:0004872	receptor activity	Extinctions
66	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
66	GO:0005216	ion channel activity	Extinctions
66	GO:0004930	G-protein coupled receptor activity	Extinctions
66	GO:0022838	substrate-specific channel activity	Extinctions
66	GO:0022803	passive transmembrane transporter activity	Extinctions
66	GO:0015267	channel activity	Extinctions
66	GO:0004857	enzyme inhibitor activity	Extinctions
66	GO:0060089	molecular transducer activity	Extinctions
66	GO:0004866	endopeptidase inhibitor activity	Extinctions
66	GO:0016868	intramolecular transferase activity, phosphotransferases	Extinctions
66	GO:0061135	endopeptidase regulator activity	Extinctions
66	GO:0001875	lipopolysaccharide receptor activity	Extinctions
66	GO:0044736	acid-sensing ion channel activity	Extinctions
66	GO:0032500	muramyl dipeptide binding	Extinctions
66	GO:0097108	hedgehog family protein binding	Extinctions
66	GO:0016019	peptidoglycan receptor activity	Extinctions
66	GO:0015280	ligand-gated sodium channel activity	Extinctions
66	GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
66	GO:0004888	transmembrane signaling receptor activity	Extinctions
66	GO:0038023	signaling receptor activity	Extinctions
66	GO:0008201	heparin binding	Extinctions
66	GO:0030414	peptidase inhibitor activity	Extinctions
66	GO:0015370	solute:sodium symporter activity	Extinctions
66	GO:0047631	ADP-ribose diphosphatase activity	Extinctions
66	GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Extinctions
66	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
66	GO:0004040	amidase activity	Extinctions
66	GO:0005094	Rho GDP-dissociation inhibitor activity	Extinctions
66	GO:0097322	7SK snRNA binding	Extinctions
66	GO:0008140	cAMP response element binding protein binding	Extinctions
66	GO:0050290	sphingomyelin phosphodiesterase D activity	Extinctions
66	GO:0004817	cysteine-tRNA ligase activity	Extinctions
66	GO:0008613	diuretic hormone activity	Extinctions
66	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Extinctions
66	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Extinctions
66	GO:0061134	peptidase regulator activity	Extinctions
66	GO:0005543	phospholipid binding	Extinctions
66	GO:0008324	cation transmembrane transporter activity	Extinctions
66	GO:0030234	enzyme regulator activity	Extinctions
67	GO:0046914	transition metal ion binding	Gains
67	GO:0008270	zinc ion binding	Gains
67	GO:0022838	substrate-specific channel activity	Gains
67	GO:0008237	metallopeptidase activity	Gains
67	GO:0015267	channel activity	Gains
67	GO:0022803	passive transmembrane transporter activity	Gains
67	GO:0043169	cation binding	Gains
67	GO:0008474	palmitoyl-(protein) hydrolase activity	Gains
67	GO:0098599	palmitoyl hydrolase activity	Gains
67	GO:0099600	transmembrane receptor activity	Gains
67	GO:0005216	ion channel activity	Gains
67	GO:0046872	metal ion binding	Gains
67	GO:0004888	transmembrane signaling receptor activity	Gains
67	GO:0004180	carboxypeptidase activity	Gains
67	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Gains
67	GO:0001872	(1->3)-beta-D-glucan binding	Gains
67	GO:0008422	beta-glucosidase activity	Gains
67	GO:0016505	peptidase activator activity involved in apoptotic process	Gains
67	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
67	GO:0008235	metalloexopeptidase activity	Gains
67	GO:0004181	metallocarboxypeptidase activity	Gains
67	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
67	GO:0015926	glucosidase activity	Gains
67	GO:0004930	G-protein coupled receptor activity	Gains
67	GO:0004601	peroxidase activity	Gains
67	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
67	GO:0046906	tetrapyrrole binding	Gains
67	GO:0005230	extracellular ligand-gated ion channel activity	Gains
67	GO:0008061	chitin binding	Gains
67	GO:0042302	structural constituent of cuticle	Gains
67	GO:0022857	transmembrane transporter activity	Gains
67	GO:0005261	cation channel activity	Gains
67	GO:0005544	calcium-dependent phospholipid binding	Gains
67	GO:0005215	transporter activity	Gains
67	GO:0038023	signaling receptor activity	Gains
67	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	Gains
67	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Gains
67	GO:0020037	heme binding	Gains
67	GO:0022891	substrate-specific transmembrane transporter activity	Gains
67	GO:0004872	receptor activity	Gains
67	GO:0030246	carbohydrate binding	Gains
67	GO:0001871	pattern binding	Gains
67	GO:0030247	polysaccharide binding	Gains
67	GO:0019842	vitamin binding	Gains
67	GO:0015075	ion transmembrane transporter activity	Gains
67	GO:0022824	transmitter-gated ion channel activity	Gains
67	GO:0022835	transmitter-gated channel activity	Gains
67	GO:0004970	ionotropic glutamate receptor activity	Gains
67	GO:0061134	peptidase regulator activity	Gains
67	GO:0004500	dopamine beta-monooxygenase activity	Gains
67	GO:0038187	pattern recognition receptor activity	Gains
67	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	Gains
67	GO:0043015	gamma-tubulin binding	Gains
67	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
67	GO:0008329	signaling pattern recognition receptor activity	Gains
67	GO:0030151	molybdenum ion binding	Gains
67	GO:0008241	peptidyl-dipeptidase activity	Gains
67	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
67	GO:0060089	molecular transducer activity	Gains
67	GO:0008238	exopeptidase activity	Gains
67	GO:0016209	antioxidant activity	Gains
67	GO:0005214	structural constituent of chitin-based cuticle	Gains
67	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
67	GO:0003964	RNA-directed DNA polymerase activity	Gains
67	GO:0001872	(1->3)-beta-D-glucan binding	Novel expansions
67	GO:0038187	pattern recognition receptor activity	Novel expansions
67	GO:0008329	signaling pattern recognition receptor activity	Novel expansions
67	GO:0016798	hydrolase activity, acting on glycosyl bonds	Novel expansions
67	GO:0030246	carbohydrate binding	Novel expansions
67	GO:0001871	pattern binding	Novel expansions
67	GO:0030247	polysaccharide binding	Novel expansions
67	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Novel expansions
67	GO:0019842	vitamin binding	Novel expansions
67	GO:0043167	ion binding	Novel expansions
67	GO:0004666	prostaglandin-endoperoxide synthase activity	Novel expansions
67	GO:0005034	osmosensor activity	Novel expansions
67	GO:0004960	thromboxane receptor activity	Novel expansions
67	GO:0004953	icosanoid receptor activity	Novel expansions
67	GO:0004954	prostanoid receptor activity	Novel expansions
67	GO:0004955	prostaglandin receptor activity	Novel expansions
67	GO:0004957	prostaglandin E receptor activity	Novel expansions
67	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	Novel expansions
67	GO:0004459	L-lactate dehydrogenase activity	Novel expansions
67	GO:0004413	homoserine kinase activity	Novel expansions
67	GO:0070279	vitamin B6 binding	Novel expansions
67	GO:0030170	pyridoxal phosphate binding	Novel expansions
67	GO:0043169	cation binding	Novel expansions
67	GO:0003987	acetate-CoA ligase activity	Novel expansions
67	GO:0016208	AMP binding	Novel expansions
67	GO:0008422	beta-glucosidase activity	Novel expansions
67	GO:0004457	lactate dehydrogenase activity	Novel expansions
67	GO:0046872	metal ion binding	Novel expansions
67	GO:0016874	ligase activity	Novel expansions
67	GO:0008235	metalloexopeptidase activity	Novel expansions
67	GO:0019202	amino acid kinase activity	Novel expansions
67	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Novel expansions
67	GO:0004565	beta-galactosidase activity	Novel expansions
67	GO:0004348	glucosylceramidase activity	Novel expansions
67	GO:0042826	histone deacetylase binding	Novel expansions
DPOND	GO:0005539	glycosaminoglycan binding	Gains
DPOND	GO:0005516	calmodulin binding	Gains
DPOND	GO:0008201	heparin binding	Gains
DPOND	GO:0005326	neurotransmitter transporter activity	Gains
DPOND	GO:0015293	symporter activity	Gains
DPOND	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	Gains
DPOND	GO:0008199	ferric iron binding	Gains
DPOND	GO:0004890	GABA-A receptor activity	Gains
DPOND	GO:0015294	solute:cation symporter activity	Gains
DPOND	GO:0015108	chloride transmembrane transporter activity	Gains
DPOND	GO:0042054	histone methyltransferase activity	Gains
DPOND	GO:0004535	poly(A)-specific ribonuclease activity	Gains
DPOND	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
DPOND	GO:0008061	chitin binding	Gains
DPOND	GO:0008276	protein methyltransferase activity	Gains
DPOND	GO:0004596	peptide alpha-N-acetyltransferase activity	Gains
DPOND	GO:0016273	arginine N-methyltransferase activity	Gains
DPOND	GO:0016274	protein-arginine N-methyltransferase activity	Gains
DPOND	GO:0008469	histone-arginine N-methyltransferase activity	Gains
DPOND	GO:0005506	iron ion binding	Gains
DPOND	GO:0005328	neurotransmitter:sodium symporter activity	Gains
DPOND	GO:0020037	heme binding	Gains
DPOND	GO:0035257	nuclear hormone receptor binding	Gains
DPOND	GO:0004819	glutamine-tRNA ligase activity	Gains
DPOND	GO:0001530	lipopolysaccharide binding	Gains
DPOND	GO:0005047	signal recognition particle binding	Gains
DPOND	GO:0031624	ubiquitin conjugating enzyme binding	Gains
DPOND	GO:0044390	ubiquitin-like protein conjugating enzyme binding	Gains
DPOND	GO:0003823	antigen binding	Gains
DPOND	GO:0016849	phosphorus-oxygen lyase activity	Gains
DPOND	GO:0005254	chloride channel activity	Gains
DPOND	GO:0046906	tetrapyrrole binding	Gains
DPOND	GO:0015370	solute:sodium symporter activity	Gains
DPOND	GO:0008170	N-methyltransferase activity	Gains
DPOND	GO:0000175	3'-5'-exoribonuclease activity	Gains
DPOND	GO:0005253	anion channel activity	Gains
DPOND	GO:0004497	monooxygenase activity	Gains
DPOND	GO:0003964	RNA-directed DNA polymerase activity	Losses
DPOND	GO:0034061	DNA polymerase activity	Losses
DPOND	GO:0140097	catalytic activity, acting on DNA	Losses
DPOND	GO:0016779	nucleotidyltransferase activity	Losses
DPOND	GO:0003676	nucleic acid binding	Losses
DPOND	GO:0004190	aspartic-type endopeptidase activity	Losses
DPOND	GO:0070001	aspartic-type peptidase activity	Losses
DPOND	GO:0008270	zinc ion binding	Losses
DPOND	GO:0046914	transition metal ion binding	Losses
DPOND	GO:0004519	endonuclease activity	Losses
DPOND	GO:1901363	heterocyclic compound binding	Losses
DPOND	GO:0097159	organic cyclic compound binding	Losses
DPOND	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DPOND	GO:0004518	nuclease activity	Losses
DPOND	GO:0003677	DNA binding	Losses
DPOND	GO:0043169	cation binding	Losses
DPOND	GO:0004984	olfactory receptor activity	Losses
DPOND	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
DPOND	GO:0046872	metal ion binding	Losses
DPOND	GO:0005549	odorant binding	Losses
DPOND	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
DPOND	GO:0099600	transmembrane receptor activity	Losses
DPOND	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
DPOND	GO:0003723	RNA binding	Losses
DPOND	GO:0004888	transmembrane signaling receptor activity	Losses
DPOND	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
DPOND	GO:0008066	glutamate receptor activity	Losses
DPOND	GO:0004872	receptor activity	Losses
DPOND	GO:0038023	signaling receptor activity	Losses
DPOND	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DPOND	GO:0003887	DNA-directed DNA polymerase activity	Losses
DPOND	GO:0004970	ionotropic glutamate receptor activity	Losses
DPOND	GO:0022824	transmitter-gated ion channel activity	Losses
DPOND	GO:0022835	transmitter-gated channel activity	Losses
DPOND	GO:0004521	endoribonuclease activity	Losses
DPOND	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
DPOND	GO:0005184	neuropeptide hormone activity	Losses
DPOND	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Losses
DPOND	GO:0005230	extracellular ligand-gated ion channel activity	Losses
DPOND	GO:0008613	diuretic hormone activity	Losses
DPOND	GO:0035586	purinergic receptor activity	Losses
DPOND	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Losses
DPOND	GO:0004503	monophenol monooxygenase activity	Losses
DPOND	GO:0050591	quinine 3-monooxygenase activity	Losses
DPOND	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
DPOND	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Losses
DPOND	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
DPOND	GO:0005212	structural constituent of eye lens	Losses
DPOND	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
DPOND	GO:0008188	neuropeptide receptor activity	Losses
DPOND	GO:0008233	peptidase activity	Losses
DPOND	GO:0008528	G-protein coupled peptide receptor activity	Losses
DPOND	GO:0048018	receptor ligand activity	Losses
DPOND	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
DPOND	GO:0001653	peptide receptor activity	Losses
DPOND	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
DPOND	GO:0060089	molecular transducer activity	Losses
DPOND	GO:0004175	endopeptidase activity	Losses
DPOND	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
DPOND	GO:0015276	ligand-gated ion channel activity	Losses
DPOND	GO:0022834	ligand-gated channel activity	Losses
DPOND	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
DPOND	GO:0005179	hormone activity	Losses
DPOND	GO:0008234	cysteine-type peptidase activity	Losses
DPOND	GO:0016755	transferase activity, transferring amino-acyl groups	Losses
DPOND	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
DPOND	GO:0043548	phosphatidylinositol 3-kinase binding	Losses
DPOND	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
DPOND	GO:0030306	ADP-ribosylation factor binding	Losses
DPOND	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Losses
DPOND	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Losses
DPOND	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
DPOND	GO:0030545	receptor regulator activity	Losses
DPOND	GO:0016788	hydrolase activity, acting on ester bonds	Losses
DPOND	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
DPOND	GO:0044877	macromolecular complex binding	Losses
DPOND	GO:0008812	choline dehydrogenase activity	Losses
DPOND	GO:0003676	nucleic acid binding	Extinctions
DPOND	GO:0034061	DNA polymerase activity	Extinctions
DPOND	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DPOND	GO:0140097	catalytic activity, acting on DNA	Extinctions
DPOND	GO:0016779	nucleotidyltransferase activity	Extinctions
DPOND	GO:0008270	zinc ion binding	Extinctions
DPOND	GO:1901363	heterocyclic compound binding	Extinctions
DPOND	GO:0097159	organic cyclic compound binding	Extinctions
DPOND	GO:0046914	transition metal ion binding	Extinctions
DPOND	GO:0004190	aspartic-type endopeptidase activity	Extinctions
DPOND	GO:0070001	aspartic-type peptidase activity	Extinctions
DPOND	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Extinctions
DPOND	GO:0004518	nuclease activity	Extinctions
DPOND	GO:0008613	diuretic hormone activity	Extinctions
DPOND	GO:0035586	purinergic receptor activity	Extinctions
DPOND	GO:0003677	DNA binding	Extinctions
DPOND	GO:0004519	endonuclease activity	Extinctions
DPOND	GO:0005184	neuropeptide hormone activity	Extinctions
DPOND	GO:0030306	ADP-ribosylation factor binding	Extinctions
DPOND	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Extinctions
DPOND	GO:0003887	DNA-directed DNA polymerase activity	Extinctions
DPOND	GO:0008066	glutamate receptor activity	Extinctions
DPOND	GO:0005044	scavenger receptor activity	Extinctions
DPOND	GO:0003723	RNA binding	Extinctions
DPOND	GO:0043169	cation binding	Extinctions
DPOND	GO:0005549	odorant binding	Extinctions
DPOND	GO:0046872	metal ion binding	Extinctions
DPOND	GO:0002039	p53 binding	Extinctions
DPOND	GO:0004736	pyruvate carboxylase activity	Extinctions
DPOND	GO:0009008	DNA-methyltransferase activity	Extinctions
DPOND	GO:0001158	enhancer sequence-specific DNA binding	Extinctions
DPOND	GO:0038024	cargo receptor activity	Extinctions
DPOND	GO:0004984	olfactory receptor activity	Extinctions
DPOND	GO:0004970	ionotropic glutamate receptor activity	Extinctions
DPOND	GO:0022824	transmitter-gated ion channel activity	Extinctions
DPOND	GO:0035326	enhancer binding	Extinctions
DPOND	GO:0022835	transmitter-gated channel activity	Extinctions
DPOND	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
DPOND	GO:0001871	pattern binding	Extinctions
DPOND	GO:0030247	polysaccharide binding	Extinctions
DPOND	GO:0008234	cysteine-type peptidase activity	Extinctions
DPOND	GO:0005179	hormone activity	Extinctions
DPOND	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
LLUNA	GO:0003964	RNA-directed DNA polymerase activity	Gains
LLUNA	GO:0034061	DNA polymerase activity	Gains
LLUNA	GO:0016779	nucleotidyltransferase activity	Gains
LLUNA	GO:0140097	catalytic activity, acting on DNA	Gains
LLUNA	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
LLUNA	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
LLUNA	GO:0019992	diacylglycerol binding	Gains
LLUNA	GO:0022843	voltage-gated cation channel activity	Gains
LLUNA	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
LLUNA	GO:0022832	voltage-gated channel activity	Gains
LLUNA	GO:0005244	voltage-gated ion channel activity	Gains
LLUNA	GO:0005509	calcium ion binding	Gains
LLUNA	GO:0003990	acetylcholinesterase activity	Gains
LLUNA	GO:0004104	cholinesterase activity	Gains
LLUNA	GO:0004518	nuclease activity	Gains
LLUNA	GO:0046873	metal ion transmembrane transporter activity	Gains
LLUNA	GO:1901363	heterocyclic compound binding	Gains
LLUNA	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Gains
LLUNA	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
LLUNA	GO:0004519	endonuclease activity	Gains
LLUNA	GO:0005326	neurotransmitter transporter activity	Gains
LLUNA	GO:0097159	organic cyclic compound binding	Gains
LLUNA	GO:0005328	neurotransmitter:sodium symporter activity	Gains
LLUNA	GO:0048037	cofactor binding	Gains
LLUNA	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
LLUNA	GO:0015370	solute:sodium symporter activity	Gains
LLUNA	GO:0022836	gated channel activity	Gains
LLUNA	GO:0008172	S-methyltransferase activity	Gains
LLUNA	GO:0016740	transferase activity	Gains
LLUNA	GO:0008233	peptidase activity	Gains
LLUNA	GO:0015291	secondary active transmembrane transporter activity	Gains
LLUNA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
LLUNA	GO:0004175	endopeptidase activity	Gains
LLUNA	GO:0016787	hydrolase activity	Gains
LLUNA	GO:0015293	symporter activity	Gains
LLUNA	GO:0070279	vitamin B6 binding	Gains
LLUNA	GO:0030170	pyridoxal phosphate binding	Gains
LLUNA	GO:0015294	solute:cation symporter activity	Gains
LLUNA	GO:0004190	aspartic-type endopeptidase activity	Gains
LLUNA	GO:0070001	aspartic-type peptidase activity	Gains
LLUNA	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Gains
LLUNA	GO:0048038	quinone binding	Gains
LLUNA	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
LLUNA	GO:0005216	ion channel activity	Gains
LLUNA	GO:0008270	zinc ion binding	Gains
LLUNA	GO:0005249	voltage-gated potassium channel activity	Gains
LLUNA	GO:0022838	substrate-specific channel activity	Gains
LLUNA	GO:0003824	catalytic activity	Gains
LLUNA	GO:0022804	active transmembrane transporter activity	Gains
LLUNA	GO:0005267	potassium channel activity	Gains
LLUNA	GO:0015075	ion transmembrane transporter activity	Gains
LLUNA	GO:0004829	threonine-tRNA ligase activity	Gains
LLUNA	GO:0004503	monophenol monooxygenase activity	Gains
LLUNA	GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	Gains
LLUNA	GO:0016922	ligand-dependent nuclear receptor binding	Gains
LLUNA	GO:0031071	cysteine desulfurase activity	Gains
LLUNA	GO:0050591	quinine 3-monooxygenase activity	Gains
LLUNA	GO:0008332	low voltage-gated calcium channel activity	Gains
LLUNA	GO:0036054	protein-malonyllysine demalonylase activity	Gains
LLUNA	GO:0036055	protein-succinyllysine desuccinylase activity	Gains
LLUNA	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
LLUNA	GO:0097003	adipokinetic hormone receptor activity	Gains
LLUNA	GO:0097004	adipokinetic hormone binding	Gains
LLUNA	GO:0048039	ubiquinone binding	Gains
LLUNA	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
LLUNA	GO:0008509	anion transmembrane transporter activity	Gains
LLUNA	GO:0003676	nucleic acid binding	Gains
LLUNA	GO:0004497	monooxygenase activity	Gains
LLUNA	GO:0022857	transmembrane transporter activity	Gains
LLUNA	GO:0005201	extracellular matrix structural constituent	Gains
LLUNA	GO:0022839	ion gated channel activity	Gains
LLUNA	GO:0008483	transaminase activity	Gains
LLUNA	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
LLUNA	GO:0015267	channel activity	Gains
LLUNA	GO:0022803	passive transmembrane transporter activity	Gains
LLUNA	GO:0008307	structural constituent of muscle	Gains
LLUNA	GO:0016500	protein-hormone receptor activity	Gains
LLUNA	GO:0005261	cation channel activity	Gains
LLUNA	GO:0046914	transition metal ion binding	Gains
LLUNA	GO:0005549	odorant binding	Losses
LLUNA	GO:0005184	neuropeptide hormone activity	Losses
LLUNA	GO:0030545	receptor regulator activity	Losses
LLUNA	GO:0048018	receptor ligand activity	Losses
LLUNA	GO:0005179	hormone activity	Losses
LLUNA	GO:0004984	olfactory receptor activity	Losses
LLUNA	GO:0048256	flap endonuclease activity	Losses
LLUNA	GO:0042171	lysophosphatidic acid acyltransferase activity	Losses
LLUNA	GO:0005550	pheromone binding	Losses
LLUNA	GO:0071855	neuropeptide receptor binding	Losses
LLUNA	GO:0071617	lysophospholipid acyltransferase activity	Losses
LLUNA	GO:0001664	G-protein coupled receptor binding	Losses
LLUNA	GO:0031267	small GTPase binding	Losses
LLUNA	GO:0019904	protein domain specific binding	Losses
LLUNA	GO:0008199	ferric iron binding	Losses
LLUNA	GO:0005515	protein binding	Losses
LLUNA	GO:0051020	GTPase binding	Losses
LLUNA	GO:0017137	Rab GTPase binding	Losses
LLUNA	GO:0015631	tubulin binding	Losses
LLUNA	GO:0008017	microtubule binding	Losses
LLUNA	GO:0003729	mRNA binding	Losses
LLUNA	GO:0017016	Ras GTPase binding	Losses
LLUNA	GO:0005501	retinoid binding	Losses
LLUNA	GO:0030306	ADP-ribosylation factor binding	Losses
LLUNA	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	Losses
LLUNA	GO:0017108	5'-flap endonuclease activity	Losses
LLUNA	GO:0030674	protein binding, bridging	Losses
LLUNA	GO:0016298	lipase activity	Losses
LLUNA	GO:0016411	acylglycerol O-acyltransferase activity	Losses
LLUNA	GO:0005272	sodium channel activity	Losses
LLUNA	GO:0005319	lipid transporter activity	Losses
LLUNA	GO:0004837	tyrosine decarboxylase activity	Losses
LLUNA	GO:0004594	pantothenate kinase activity	Losses
LLUNA	GO:0016084	myostimulatory hormone activity	Losses
LLUNA	GO:0050824	water binding	Losses
LLUNA	GO:0050825	ice binding	Losses
LLUNA	GO:0001096	TFIIF-class transcription factor binding	Losses
LLUNA	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	Losses
LLUNA	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Losses
LLUNA	GO:0016848	carbon-halide lyase activity	Losses
LLUNA	GO:0004792	thiosulfate sulfurtransferase activity	Losses
LLUNA	GO:0042302	structural constituent of cuticle	Losses
LLUNA	GO:0005488	binding	Losses
LLUNA	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
LLUNA	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Losses
LLUNA	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Losses
LLUNA	GO:0008253	5'-nucleotidase activity	Losses
LLUNA	GO:0019899	enzyme binding	Losses
LLUNA	GO:0016854	racemase and epimerase activity	Losses
LLUNA	GO:0015171	amino acid transmembrane transporter activity	Losses
LLUNA	GO:0004386	helicase activity	Losses
LLUNA	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Losses
LLUNA	GO:0097472	cyclin-dependent protein kinase activity	Losses
LLUNA	GO:0005549	odorant binding	Extinctions
LLUNA	GO:0005184	neuropeptide hormone activity	Extinctions
LLUNA	GO:0005179	hormone activity	Extinctions
LLUNA	GO:0004984	olfactory receptor activity	Extinctions
LLUNA	GO:0030545	receptor regulator activity	Extinctions
LLUNA	GO:0048018	receptor ligand activity	Extinctions
LLUNA	GO:0048256	flap endonuclease activity	Extinctions
LLUNA	GO:0031267	small GTPase binding	Extinctions
LLUNA	GO:0071855	neuropeptide receptor binding	Extinctions
LLUNA	GO:0005550	pheromone binding	Extinctions
LLUNA	GO:0017137	Rab GTPase binding	Extinctions
LLUNA	GO:0017016	Ras GTPase binding	Extinctions
LLUNA	GO:0051020	GTPase binding	Extinctions
LLUNA	GO:0008199	ferric iron binding	Extinctions
LLUNA	GO:0001664	G-protein coupled receptor binding	Extinctions
LLUNA	GO:0030674	protein binding, bridging	Extinctions
LLUNA	GO:0005501	retinoid binding	Extinctions
LLUNA	GO:0030306	ADP-ribosylation factor binding	Extinctions
LLUNA	GO:0017108	5'-flap endonuclease activity	Extinctions
LLUNA	GO:0015631	tubulin binding	Extinctions
LLUNA	GO:0008017	microtubule binding	Extinctions
LLUNA	GO:0004386	helicase activity	Extinctions
LLUNA	GO:0004594	pantothenate kinase activity	Extinctions
LLUNA	GO:0016084	myostimulatory hormone activity	Extinctions
LLUNA	GO:0050824	water binding	Extinctions
LLUNA	GO:0050825	ice binding	Extinctions
LLUNA	GO:0001096	TFIIF-class transcription factor binding	Extinctions
LLUNA	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	Extinctions
LLUNA	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	Extinctions
LLUNA	GO:0071617	lysophospholipid acyltransferase activity	Extinctions
LLUNA	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Extinctions
LLUNA	GO:0003729	mRNA binding	Extinctions
LLUNA	GO:0019904	protein domain specific binding	Extinctions
LLUNA	GO:0042171	lysophosphatidic acid acyltransferase activity	Extinctions
LLUNA	GO:0004535	poly(A)-specific ribonuclease activity	Extinctions
LLUNA	GO:0019899	enzyme binding	Extinctions
LLUNA	GO:0000175	3'-5'-exoribonuclease activity	Extinctions
LLUNA	GO:0005319	lipid transporter activity	Extinctions
LLUNA	GO:0005515	protein binding	Extinctions
HVITR	GO:0003964	RNA-directed DNA polymerase activity	Gains
HVITR	GO:0140097	catalytic activity, acting on DNA	Gains
HVITR	GO:0034061	DNA polymerase activity	Gains
HVITR	GO:0017137	Rab GTPase binding	Gains
HVITR	GO:0016779	nucleotidyltransferase activity	Gains
HVITR	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HVITR	GO:0051020	GTPase binding	Gains
HVITR	GO:0017016	Ras GTPase binding	Gains
HVITR	GO:0031267	small GTPase binding	Gains
HVITR	GO:0017160	Ral GTPase binding	Gains
HVITR	GO:0004035	alkaline phosphatase activity	Gains
HVITR	GO:0005178	integrin binding	Gains
HVITR	GO:0008188	neuropeptide receptor activity	Gains
HVITR	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
HVITR	GO:0016886	ligase activity, forming phosphoric ester bonds	Gains
HVITR	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
HVITR	GO:0005524	ATP binding	Gains
HVITR	GO:0032559	adenyl ribonucleotide binding	Gains
HVITR	GO:0001653	peptide receptor activity	Gains
HVITR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HVITR	GO:0015085	calcium ion transmembrane transporter activity	Gains
HVITR	GO:0005262	calcium channel activity	Gains
HVITR	GO:0003824	catalytic activity	Gains
HVITR	GO:0099600	transmembrane receptor activity	Gains
HVITR	GO:0004872	receptor activity	Gains
HVITR	GO:0008233	peptidase activity	Gains
HVITR	GO:0030554	adenyl nucleotide binding	Gains
HVITR	GO:0060089	molecular transducer activity	Gains
HVITR	GO:0061134	peptidase regulator activity	Gains
HVITR	GO:0015197	peptide transporter activity	Gains
HVITR	GO:0008528	G-protein coupled peptide receptor activity	Gains
HVITR	GO:0004040	amidase activity	Gains
HVITR	GO:0008381	mechanically-gated ion channel activity	Gains
HVITR	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Gains
HVITR	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
HVITR	GO:0004484	mRNA guanylyltransferase activity	Gains
HVITR	GO:0022833	mechanically gated channel activity	Gains
HVITR	GO:0004565	beta-galactosidase activity	Gains
HVITR	GO:0045159	myosin II binding	Gains
HVITR	GO:0043168	anion binding	Gains
HVITR	GO:0032027	myosin light chain binding	Gains
HVITR	GO:0031208	POZ domain binding	Gains
HVITR	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
HVITR	GO:0008565	protein transporter activity	Gains
HVITR	GO:0010181	FMN binding	Gains
HVITR	GO:0008234	cysteine-type peptidase activity	Gains
HVITR	GO:0003964	RNA-directed DNA polymerase activity	Losses
HVITR	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
HVITR	GO:0031078	histone deacetylase activity (H3-K14 specific)	Losses
HVITR	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Losses
HVITR	GO:0004463	leukotriene-A4 hydrolase activity	Losses
HVITR	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Losses
HVITR	GO:0034739	histone deacetylase activity (H4-K16 specific)	Losses
HVITR	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Losses
HVITR	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Losses
HVITR	GO:0032129	histone deacetylase activity (H3-K9 specific)	Losses
HVITR	GO:0070001	aspartic-type peptidase activity	Losses
HVITR	GO:0004190	aspartic-type endopeptidase activity	Losses
HVITR	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
HVITR	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
HVITR	GO:0016779	nucleotidyltransferase activity	Losses
HVITR	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
HVITR	GO:0017136	NAD-dependent histone deacetylase activity	Losses
HVITR	GO:0034061	DNA polymerase activity	Losses
HVITR	GO:0046872	metal ion binding	Losses
HVITR	GO:0016803	ether hydrolase activity	Losses
HVITR	GO:0043169	cation binding	Losses
HVITR	GO:0034979	NAD-dependent protein deacetylase activity	Losses
HVITR	GO:0004004	ATP-dependent RNA helicase activity	Losses
HVITR	GO:0005507	copper ion binding	Losses
HVITR	GO:0008186	RNA-dependent ATPase activity	Losses
HVITR	GO:0016801	hydrolase activity, acting on ether bonds	Losses
HVITR	GO:0004407	histone deacetylase activity	Losses
HVITR	GO:0004576	oligosaccharyl transferase activity	Losses
HVITR	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Losses
HVITR	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Losses
HVITR	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
HVITR	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
HVITR	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
HVITR	GO:0008908	isochorismatase activity	Losses
HVITR	GO:0004097	catechol oxidase activity	Losses
HVITR	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
HVITR	GO:0004995	tachykinin receptor activity	Losses
HVITR	GO:0004950	chemokine receptor activity	Losses
HVITR	GO:0031005	filamin binding	Losses
HVITR	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
HVITR	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Losses
HVITR	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
HVITR	GO:0034185	apolipoprotein binding	Losses
HVITR	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
HVITR	GO:0015386	potassium:proton antiporter activity	Losses
HVITR	GO:0032028	myosin head/neck binding	Losses
HVITR	GO:0031489	myosin V binding	Losses
HVITR	GO:0003873	6-phosphofructo-2-kinase activity	Losses
HVITR	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Losses
HVITR	GO:0097109	neuroligin family protein binding	Losses
HVITR	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Losses
HVITR	GO:0008531	riboflavin kinase activity	Losses
HVITR	GO:0036263	L-DOPA monooxygenase activity	Losses
HVITR	GO:0036264	dopamine monooxygenase activity	Losses
HVITR	GO:0050111	mycocerosate synthase activity	Losses
HVITR	GO:0070854	myosin VI heavy chain binding	Losses
HVITR	GO:0070855	myosin VI head/neck binding	Losses
HVITR	GO:0042979	ornithine decarboxylase regulator activity	Losses
HVITR	GO:2001070	starch binding	Losses
HVITR	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
HVITR	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
HVITR	GO:0003724	RNA helicase activity	Losses
HVITR	GO:0033558	protein deacetylase activity	Losses
HVITR	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
HVITR	GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
HVITR	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
HVITR	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
HVITR	GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
HVITR	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
HVITR	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
HVITR	GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
HVITR	GO:0070001	aspartic-type peptidase activity	Extinctions
HVITR	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HVITR	GO:0017136	NAD-dependent histone deacetylase activity	Extinctions
HVITR	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HVITR	GO:0005507	copper ion binding	Extinctions
HVITR	GO:0034979	NAD-dependent protein deacetylase activity	Extinctions
HVITR	GO:0004407	histone deacetylase activity	Extinctions
HVITR	GO:0004576	oligosaccharyl transferase activity	Extinctions
HVITR	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
HVITR	GO:0016779	nucleotidyltransferase activity	Extinctions
HVITR	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Extinctions
HVITR	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
HVITR	GO:0008908	isochorismatase activity	Extinctions
HVITR	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	Extinctions
HVITR	GO:0008531	riboflavin kinase activity	Extinctions
HVITR	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
HVITR	GO:0034061	DNA polymerase activity	Extinctions
HVITR	GO:0033558	protein deacetylase activity	Extinctions
HVITR	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
HVITR	GO:0046872	metal ion binding	Extinctions
HVITR	GO:0019213	deacetylase activity	Extinctions
HVITR	GO:0043169	cation binding	Extinctions
HVITR	GO:0015932	nucleobase-containing compound transmembrane transporter activity	Extinctions
HVITR	GO:1901505	carbohydrate derivative transmembrane transporter activity	Extinctions
HVITR	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Extinctions
HVITR	GO:0016531	copper chaperone activity	Extinctions
HVITR	GO:0036080	purine nucleotide-sugar transmembrane transporter activity	Extinctions
HVITR	GO:0004496	mevalonate kinase activity	Extinctions
HVITR	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Extinctions
HVITR	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity	Extinctions
HVITR	GO:0005464	UDP-xylose transmembrane transporter activity	Extinctions
HVITR	GO:0005457	GDP-fucose transmembrane transporter activity	Extinctions
HVITR	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
HVITR	GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	Extinctions
HVITR	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Extinctions
HVITR	GO:0008613	diuretic hormone activity	Extinctions
HVITR	GO:0016757	transferase activity, transferring glycosyl groups	Extinctions
HVITR	GO:0003954	NADH dehydrogenase activity	Extinctions
HE5	GO:0003964	RNA-directed DNA polymerase activity	Gains
HE5	GO:0004190	aspartic-type endopeptidase activity	Gains
HE5	GO:0070001	aspartic-type peptidase activity	Gains
HE5	GO:0034061	DNA polymerase activity	Gains
HE5	GO:0015929	hexosaminidase activity	Gains
HE5	GO:0004871	signal transducer activity	Gains
HE5	GO:0097003	adipokinetic hormone receptor activity	Gains
HE5	GO:0097004	adipokinetic hormone binding	Gains
HE5	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
HE5	GO:0052870	tocopherol omega-hydroxylase activity	Gains
HE5	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
HE5	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
HE5	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
HE5	GO:0042302	structural constituent of cuticle	Gains
HE5	GO:0017046	peptide hormone binding	Gains
HE5	GO:0018685	alkane 1-monooxygenase activity	Gains
HE5	GO:0005416	cation:amino acid symporter activity	Gains
HE5	GO:0005283	sodium:amino acid symporter activity	Gains
HE5	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
HE5	GO:0099600	transmembrane receptor activity	Gains
HE5	GO:0038023	signaling receptor activity	Gains
HE5	GO:0004930	G-protein coupled receptor activity	Gains
HE5	GO:0015081	sodium ion transmembrane transporter activity	Gains
HE5	GO:0015291	secondary active transmembrane transporter activity	Gains
HE5	GO:0005214	structural constituent of chitin-based cuticle	Gains
HE5	GO:0004888	transmembrane signaling receptor activity	Gains
HE5	GO:0004872	receptor activity	Gains
HE5	GO:0140097	catalytic activity, acting on DNA	Gains
HE5	GO:0015293	symporter activity	Gains
HE5	GO:0016779	nucleotidyltransferase activity	Gains
HE5	GO:0019992	diacylglycerol binding	Gains
HE5	GO:0052723	inositol hexakisphosphate 1-kinase activity	Gains
HE5	GO:0052724	inositol hexakisphosphate 3-kinase activity	Gains
HE5	GO:0005432	calcium:sodium antiporter activity	Gains
HE5	GO:0000828	inositol hexakisphosphate kinase activity	Gains
HE5	GO:0004645	phosphorylase activity	Gains
HE5	GO:0000832	inositol hexakisphosphate 5-kinase activity	Gains
HE5	GO:0019842	vitamin binding	Gains
HE5	GO:0004016	adenylate cyclase activity	Gains
HE5	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
HE5	GO:0072341	modified amino acid binding	Gains
HE5	GO:0015368	calcium:cation antiporter activity	Gains
HE5	GO:0060089	molecular transducer activity	Gains
HE5	GO:0043169	cation binding	Gains
HE5	GO:0015075	ion transmembrane transporter activity	Gains
HE5	GO:0015294	solute:cation symporter activity	Gains
HE5	GO:0046872	metal ion binding	Gains
HE5	GO:0022857	transmembrane transporter activity	Gains
HE5	GO:0005343	organic acid:sodium symporter activity	Gains
HE5	GO:0008519	ammonium transmembrane transporter activity	Gains
HE5	GO:0015179	L-amino acid transmembrane transporter activity	Gains
HE5	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HE5	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Gains
HE5	GO:0004364	glutathione transferase activity	Gains
HE5	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
HE5	GO:0016500	protein-hormone receptor activity	Gains
HE5	GO:0008324	cation transmembrane transporter activity	Gains
HE5	GO:0008188	neuropeptide receptor activity	Gains
HE5	GO:0033218	amide binding	Gains
HE5	GO:0018834	dichloromethane dehalogenase activity	Gains
HE5	GO:0008940	nitrate reductase activity	Gains
HE5	GO:0036082	extracellular phenylacetaldehyde-gated ion channel activity	Gains
HE5	GO:0005026	transforming growth factor beta receptor activity, type II	Gains
HE5	GO:0004097	catechol oxidase activity	Gains
HE5	GO:0016154	pyrimidine-nucleoside phosphorylase activity	Gains
HE5	GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Gains
HE5	GO:0030350	iron-responsive element binding	Gains
HE5	GO:0034185	apolipoprotein binding	Gains
HE5	GO:0008490	arsenite secondary active transmembrane transporter activity	Gains
HE5	GO:0008456	alpha-N-acetylgalactosaminidase activity	Gains
HE5	GO:0035237	corazonin receptor activity	Gains
HE5	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Gains
HE5	GO:0044620	ACP phosphopantetheine attachment site binding	Gains
HE5	GO:0000036	acyl carrier activity	Gains
HE5	GO:0016785	transferase activity, transferring selenium-containing groups	Gains
HE5	GO:0005329	dopamine transmembrane transporter activity	Gains
HE5	GO:0031177	phosphopantetheine binding	Gains
HE5	GO:0004375	glycine dehydrogenase (decarboxylating) activity	Gains
HE5	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
HE5	GO:0004321	fatty-acyl-CoA synthase activity	Gains
HE5	GO:0003785	actin monomer binding	Gains
HE5	GO:0070273	phosphatidylinositol-4-phosphate binding	Gains
HE5	GO:0004459	L-lactate dehydrogenase activity	Gains
HE5	GO:0015054	gastrin receptor activity	Gains
HE5	GO:0043334	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Gains
HE5	GO:0003838	sterol 24-C-methyltransferase activity	Gains
HE5	GO:0009703	nitrate reductase (NADH) activity	Gains
HE5	GO:0036263	L-DOPA monooxygenase activity	Gains
HE5	GO:0036264	dopamine monooxygenase activity	Gains
HE5	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
HE5	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	Gains
HE5	GO:0008829	dCTP deaminase activity	Gains
HE5	GO:0052692	raffinose alpha-galactosidase activity	Gains
HE5	GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Gains
HE5	GO:0097109	neuroligin family protein binding	Gains
HE5	GO:0030623	U5 snRNA binding	Gains
HE5	GO:0015446	ATPase-coupled arsenite transmembrane transporter activity	Gains
HE5	GO:0004807	triose-phosphate isomerase activity	Gains
HE5	GO:0016918	retinal binding	Gains
HE5	GO:0004557	alpha-galactosidase activity	Gains
HE5	GO:0004587	ornithine-oxo-acid transaminase activity	Gains
HE5	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
HE5	GO:0015105	arsenite transmembrane transporter activity	Gains
HE5	GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
HE5	GO:0051192	prosthetic group binding	Gains
HE5	GO:0009032	thymidine phosphorylase activity	Gains
HE5	GO:0015222	serotonin transmembrane transporter activity	Gains
HE5	GO:0019811	cocaine binding	Gains
HE5	GO:0042943	D-amino acid transmembrane transporter activity	Gains
HE5	GO:0051766	inositol trisphosphate kinase activity	Gains
HE5	GO:0070330	aromatase activity	Gains
HE5	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HE5	GO:0071617	lysophospholipid acyltransferase activity	Gains
HE5	GO:0016787	hydrolase activity	Losses
HE5	GO:0004527	exonuclease activity	Losses
HE5	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HE5	GO:0003678	DNA helicase activity	Losses
HE5	GO:0008859	exoribonuclease II activity	Losses
HE5	GO:0008527	taste receptor activity	Losses
HE5	GO:0009008	DNA-methyltransferase activity	Losses
HE5	GO:0033041	sweet taste receptor activity	Losses
HE5	GO:1901363	heterocyclic compound binding	Losses
HE5	GO:0140097	catalytic activity, acting on DNA	Losses
HE5	GO:0097159	organic cyclic compound binding	Losses
HE5	GO:0000156	phosphorelay response regulator activity	Losses
HE5	GO:0003824	catalytic activity	Losses
HE5	GO:0004518	nuclease activity	Losses
HE5	GO:0030170	pyridoxal phosphate binding	Losses
HE5	GO:0070279	vitamin B6 binding	Losses
HE5	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
HE5	GO:0005385	zinc ion transmembrane transporter activity	Losses
HE5	GO:0008195	phosphatidate phosphatase activity	Losses
HE5	GO:0004751	ribose-5-phosphate isomerase activity	Losses
HE5	GO:0003913	DNA photolyase activity	Losses
HE5	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
HE5	GO:0003777	microtubule motor activity	Losses
HE5	GO:0003774	motor activity	Losses
HE5	GO:0030246	carbohydrate binding	Losses
HE5	GO:0042578	phosphoric ester hydrolase activity	Losses
HE5	GO:0008233	peptidase activity	Losses
HE5	GO:0016791	phosphatase activity	Losses
HE5	GO:0004857	enzyme inhibitor activity	Losses
HE5	GO:0046915	transition metal ion transmembrane transporter activity	Losses
HE5	GO:0004035	alkaline phosphatase activity	Losses
HE5	GO:0005344	oxygen carrier activity	Losses
HE5	GO:1901677	phosphate transmembrane transporter activity	Losses
HE5	GO:0005452	inorganic anion exchanger activity	Losses
HE5	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Losses
HE5	GO:0015114	phosphate ion transmembrane transporter activity	Losses
HE5	GO:0008509	anion transmembrane transporter activity	Losses
HE5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HE5	GO:0005506	iron ion binding	Losses
HE5	GO:0000156	phosphorelay response regulator activity	Extinctions
HE5	GO:0033041	sweet taste receptor activity	Extinctions
HE5	GO:0004751	ribose-5-phosphate isomerase activity	Extinctions
HE5	GO:0005506	iron ion binding	Extinctions
HE5	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Extinctions
HE5	GO:0140097	catalytic activity, acting on DNA	Extinctions
HE5	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HE5	GO:0070001	aspartic-type peptidase activity	Extinctions
HE5	GO:0034061	DNA polymerase activity	Extinctions
HE5	GO:0008527	taste receptor activity	Extinctions
HE5	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Extinctions
HE5	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HE5	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Extinctions
HE5	GO:1901363	heterocyclic compound binding	Extinctions
HE5	GO:0097159	organic cyclic compound binding	Extinctions
HE5	GO:0004725	protein tyrosine phosphatase activity	Extinctions
HE5	GO:0030983	mismatched DNA binding	Extinctions
HE5	GO:0008172	S-methyltransferase activity	Extinctions
HE5	GO:0016803	ether hydrolase activity	Extinctions
HE5	GO:0016307	phosphatidylinositol phosphate kinase activity	Extinctions
HE5	GO:0046915	transition metal ion transmembrane transporter activity	Extinctions
HE7	GO:0016783	sulfurtransferase activity	Gains
HE7	GO:0005215	transporter activity	Gains
HE7	GO:0022892	substrate-specific transporter activity	Gains
HE7	GO:0022891	substrate-specific transmembrane transporter activity	Gains
HE7	GO:0022857	transmembrane transporter activity	Gains
HE7	GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
HE7	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
HE7	GO:0008603	cAMP-dependent protein kinase regulator activity	Gains
HE7	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
HE7	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Gains
HE7	GO:0004837	tyrosine decarboxylase activity	Gains
HE7	GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	Gains
HE7	GO:0015075	ion transmembrane transporter activity	Gains
HE7	GO:0016615	malate dehydrogenase activity	Gains
HE7	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
HE7	GO:0051540	metal cluster binding	Gains
HE7	GO:0051536	iron-sulfur cluster binding	Gains
HE7	GO:0048037	cofactor binding	Gains
HE7	GO:0008233	peptidase activity	Gains
HE7	GO:0004692	cGMP-dependent protein kinase activity	Gains
HE7	GO:0030594	neurotransmitter receptor activity	Gains
HE7	GO:0004888	transmembrane signaling receptor activity	Gains
HE7	GO:0061783	peptidoglycan muralytic activity	Gains
HE7	GO:0015291	secondary active transmembrane transporter activity	Gains
HE7	GO:0046592	polyamine oxidase activity	Gains
HE7	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Gains
HE7	GO:0004185	serine-type carboxypeptidase activity	Gains
HE7	GO:0030060	L-malate dehydrogenase activity	Gains
HE7	GO:0046872	metal ion binding	Gains
HE7	GO:0022838	substrate-specific channel activity	Gains
HE7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Gains
HE7	GO:0010181	FMN binding	Gains
HE7	GO:0099600	transmembrane receptor activity	Gains
HE7	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HE7	GO:0043169	cation binding	Gains
HE7	GO:0042302	structural constituent of cuticle	Gains
HE7	GO:0015293	symporter activity	Gains
HE7	GO:0034061	DNA polymerase activity	Gains
HE7	GO:0016307	phosphatidylinositol phosphate kinase activity	Gains
HE7	GO:0015267	channel activity	Gains
HE7	GO:0022803	passive transmembrane transporter activity	Gains
HE7	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
HE7	GO:0051287	NAD binding	Gains
HE7	GO:0048038	quinone binding	Gains
HE7	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Gains
HE7	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Gains
HE7	GO:0070008	serine-type exopeptidase activity	Gains
HE7	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Gains
HE7	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
HE7	GO:0004792	thiosulfate sulfurtransferase activity	Gains
HE7	GO:0003964	RNA-directed DNA polymerase activity	Gains
HE7	GO:0005216	ion channel activity	Gains
HE7	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
HE7	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
HE7	GO:0005328	neurotransmitter:sodium symporter activity	Gains
HE7	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
HE7	GO:0004970	ionotropic glutamate receptor activity	Gains
HE7	GO:0022824	transmitter-gated ion channel activity	Gains
HE7	GO:0022835	transmitter-gated channel activity	Gains
HE7	GO:0004180	carboxypeptidase activity	Losses
HE7	GO:0030594	neurotransmitter receptor activity	Losses
HE7	GO:0004181	metallocarboxypeptidase activity	Losses
HE7	GO:0008238	exopeptidase activity	Losses
HE7	GO:0008270	zinc ion binding	Losses
HE7	GO:0003676	nucleic acid binding	Losses
HE7	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
HE7	GO:0033971	hydroxyisourate hydrolase activity	Losses
HE7	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
HE7	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
HE7	GO:0004747	ribokinase activity	Losses
HE7	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
HE7	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
HE7	GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity	Losses
HE7	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
HE7	GO:0050038	L-xylulose reductase (NADP+) activity	Losses
HE7	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HE7	GO:0004386	helicase activity	Losses
HE7	GO:0003678	DNA helicase activity	Losses
HE7	GO:0043958	acryloyl-CoA reductase activity	Losses
HE7	GO:0004971	AMPA glutamate receptor activity	Losses
HE7	GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Losses
HE7	GO:0008169	C-methyltransferase activity	Losses
HE7	GO:0016084	myostimulatory hormone activity	Losses
HE7	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Losses
HE7	GO:0019788	NEDD8 transferase activity	Losses
HE7	GO:0030580	quinone cofactor methyltransferase activity	Losses
HE7	GO:0000403	Y-form DNA binding	Losses
HE7	GO:0003933	GTP cyclohydrolase activity	Losses
HE7	GO:0003934	GTP cyclohydrolase I activity	Losses
HE7	GO:0033814	propanoyl-CoA C-acyltransferase activity	Losses
HE7	GO:0004197	cysteine-type endopeptidase activity	Losses
HE7	GO:0046914	transition metal ion binding	Losses
HE7	GO:0008235	metalloexopeptidase activity	Losses
HE7	GO:0004970	ionotropic glutamate receptor activity	Losses
HE7	GO:0022824	transmitter-gated ion channel activity	Losses
HE7	GO:0022835	transmitter-gated channel activity	Losses
HE7	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
HE7	GO:0004972	NMDA glutamate receptor activity	Losses
HE7	GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
HE7	GO:0004185	serine-type carboxypeptidase activity	Losses
HE7	GO:0003681	bent DNA binding	Losses
HE7	GO:0008613	diuretic hormone activity	Losses
HE7	GO:0009922	fatty acid elongase activity	Losses
HE7	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
HE7	GO:0008066	glutamate receptor activity	Losses
HE7	GO:0008233	peptidase activity	Losses
HE7	GO:0033549	MAP kinase phosphatase activity	Losses
HE7	GO:0070008	serine-type exopeptidase activity	Losses
HE7	GO:0099528	G-protein coupled neurotransmitter receptor activity	Losses
HE7	GO:0015464	acetylcholine receptor activity	Losses
HE7	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Losses
HE7	GO:0019238	cyclohydrolase activity	Losses
HE7	GO:0043138	3'-5' DNA helicase activity	Losses
HE7	GO:0016907	G-protein coupled acetylcholine receptor activity	Losses
HE7	GO:0005154	epidermal growth factor receptor binding	Losses
HE7	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
HE7	GO:0000217	DNA secondary structure binding	Losses
HE7	GO:0033971	hydroxyisourate hydrolase activity	Extinctions
HE7	GO:0004971	AMPA glutamate receptor activity	Extinctions
HE7	GO:0016084	myostimulatory hormone activity	Extinctions
HE7	GO:0003933	GTP cyclohydrolase activity	Extinctions
HE7	GO:0003934	GTP cyclohydrolase I activity	Extinctions
HE7	GO:0004180	carboxypeptidase activity	Extinctions
HE7	GO:0004386	helicase activity	Extinctions
HE7	GO:0004972	NMDA glutamate receptor activity	Extinctions
HE7	GO:0004185	serine-type carboxypeptidase activity	Extinctions
HE7	GO:0003681	bent DNA binding	Extinctions
HE7	GO:0008613	diuretic hormone activity	Extinctions
HE7	GO:0005261	cation channel activity	Extinctions
HE7	GO:0070008	serine-type exopeptidase activity	Extinctions
HE7	GO:0019238	cyclohydrolase activity	Extinctions
HE7	GO:0005244	voltage-gated ion channel activity	Extinctions
HE7	GO:0022832	voltage-gated channel activity	Extinctions
HE7	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
HE7	GO:0071855	neuropeptide receptor binding	Extinctions
HE7	GO:0003676	nucleic acid binding	Extinctions
HE7	GO:0003678	DNA helicase activity	Extinctions
HE1	GO:0015238	drug transmembrane transporter activity	Gains
HE1	GO:0090484	drug transporter activity	Gains
HE1	GO:0005319	lipid transporter activity	Gains
HE1	GO:0003777	microtubule motor activity	Gains
HE1	GO:0003774	motor activity	Gains
HE1	GO:0004305	ethanolamine kinase activity	Gains
HE1	GO:0004103	choline kinase activity	Gains
HE1	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
HE1	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
HE1	GO:0005524	ATP binding	Gains
HE1	GO:0032559	adenyl ribonucleotide binding	Gains
HE1	GO:0016787	hydrolase activity	Gains
HE1	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
HE1	GO:0042910	xenobiotic transmembrane transporter activity	Gains
HE1	GO:0016301	kinase activity	Gains
HE1	GO:0030554	adenyl nucleotide binding	Gains
HE1	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
HE1	GO:0022804	active transmembrane transporter activity	Gains
HE1	GO:0003824	catalytic activity	Gains
HE1	GO:0004674	protein serine/threonine kinase activity	Gains
HE1	GO:0015101	organic cation transmembrane transporter activity	Gains
HE1	GO:0050308	sugar-phosphatase activity	Gains
HE1	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
HE1	GO:0003993	acid phosphatase activity	Gains
HE1	GO:0042623	ATPase activity, coupled	Gains
HE1	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HE1	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HE1	GO:0005452	inorganic anion exchanger activity	Gains
HE1	GO:0019200	carbohydrate kinase activity	Gains
HE1	GO:0005548	phospholipid transporter activity	Gains
HE1	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Gains
HE1	GO:0043168	anion binding	Gains
HE1	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
HE1	GO:0043492	ATPase activity, coupled to movement of substances	Gains
HE1	GO:0035639	purine ribonucleoside triphosphate binding	Gains
HE1	GO:0032555	purine ribonucleotide binding	Gains
HE1	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Gains
HE1	GO:0015399	primary active transmembrane transporter activity	Gains
HE1	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Gains
HE1	GO:0016887	ATPase activity	Gains
HE1	GO:0005313	L-glutamate transmembrane transporter activity	Gains
HE1	GO:0008307	structural constituent of muscle	Gains
HE1	GO:0004012	phospholipid-translocating ATPase activity	Gains
HE1	GO:0008859	exoribonuclease II activity	Gains
HE1	GO:0019203	carbohydrate phosphatase activity	Gains
HE1	GO:0015172	acidic amino acid transmembrane transporter activity	Gains
HE1	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
HE1	GO:0016307	phosphatidylinositol phosphate kinase activity	Gains
HE1	GO:0005509	calcium ion binding	Gains
HE1	GO:0016791	phosphatase activity	Gains
HE1	GO:0005215	transporter activity	Gains
HE1	GO:0017076	purine nucleotide binding	Gains
HE1	GO:0097367	carbohydrate derivative binding	Gains
HE1	GO:0032553	ribonucleotide binding	Gains
HE1	GO:0004312	fatty acid synthase activity	Gains
HE1	GO:0015179	L-amino acid transmembrane transporter activity	Gains
HE1	GO:0005086	ARF guanyl-nucleotide exchange factor activity	Gains
HE1	GO:0004687	myosin light chain kinase activity	Gains
HE1	GO:0036094	small molecule binding	Gains
HE1	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Gains
HE1	GO:0008484	sulfuric ester hydrolase activity	Gains
HE1	GO:0022857	transmembrane transporter activity	Gains
HE1	GO:0008017	microtubule binding	Gains
HE1	GO:0005096	GTPase activator activity	Gains
HE1	GO:0042302	structural constituent of cuticle	Gains
HE1	GO:0008349	MAP kinase kinase kinase kinase activity	Gains
HE1	GO:0008331	high voltage-gated calcium channel activity	Gains
HE1	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	Gains
HE1	GO:0046624	sphingolipid transporter activity	Gains
HE1	GO:0046625	sphingolipid binding	Gains
HE1	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Gains
HE1	GO:0015619	thiamine pyrophosphate-transporting ATPase activity	Gains
HE1	GO:0016231	beta-N-acetylglucosaminidase activity	Gains
HE1	GO:0140033	acetylation-dependent protein binding	Gains
HE1	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
HE1	GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Gains
HE1	GO:0016785	transferase activity, transferring selenium-containing groups	Gains
HE1	GO:0005436	sodium:phosphate symporter activity	Gains
HE1	GO:0047886	farnesol dehydrogenase activity	Gains
HE1	GO:0050564	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity	Gains
HE1	GO:0042806	fucose binding	Gains
HE1	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	Gains
HE1	GO:0004396	hexokinase activity	Gains
HE1	GO:0017128	phospholipid scramblase activity	Gains
HE1	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Gains
HE1	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
HE1	GO:0008798	beta-aspartyl-peptidase activity	Gains
HE1	GO:0045118	azole transporter activity	Gains
HE1	GO:0019158	mannokinase activity	Gains
HE1	GO:0031434	mitogen-activated protein kinase kinase binding	Gains
HE1	GO:0004340	glucokinase activity	Gains
HE1	GO:0004346	glucose-6-phosphatase activity	Gains
HE1	GO:0042656	JUN kinase kinase kinase kinase activity	Gains
HE1	GO:0004301	epoxide hydrolase activity	Gains
HE1	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
HE1	GO:0004454	ketohexokinase activity	Gains
HE1	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
HE1	GO:0004476	mannose-6-phosphate isomerase activity	Gains
HE1	GO:0003872	6-phosphofructokinase activity	Gains
HE1	GO:0008865	fructokinase activity	Gains
HE1	GO:0035529	NADH pyrophosphatase activity	Gains
HE1	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Gains
HE1	GO:0008800	beta-lactamase activity	Gains
HE1	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Gains
HE1	GO:0035620	ceramide transporter activity	Gains
HE1	GO:1901474	azole transmembrane transporter activity	Gains
HE1	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
HE1	GO:0047964	glyoxylate reductase activity	Gains
HE1	GO:0051183	vitamin transporter activity	Gains
HE1	GO:0033041	sweet taste receptor activity	Gains
HE1	GO:0004734	pyrimidodiazepine synthase activity	Gains
HE1	GO:0070577	lysine-acetylated histone binding	Gains
HE1	GO:0097001	ceramide binding	Gains
HE1	GO:0050357	tropinesterase activity	Gains
HE1	GO:0008093	cytoskeletal adaptor activity	Gains
HE1	GO:0015234	thiamine transmembrane transporter activity	Gains
HE1	GO:0030267	glyoxylate reductase (NADP) activity	Gains
HE1	GO:0004802	transketolase activity	Gains
HE1	GO:0050309	sugar-terminal-phosphatase activity	Gains
HE1	GO:0004561	alpha-N-acetylglucosaminidase activity	Gains
HE1	GO:0004567	beta-mannosidase activity	Gains
HE1	GO:0004556	alpha-amylase activity	Gains
HE1	GO:0004528	phosphodiesterase I activity	Gains
HE1	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
HE1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Gains
HE1	GO:0008927	mannonate dehydratase activity	Gains
HE1	GO:0004679	AMP-activated protein kinase activity	Gains
HE1	GO:0004611	phosphoenolpyruvate carboxykinase activity	Gains
HE1	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Gains
HE1	GO:0050112	inositol 2-dehydrogenase activity	Gains
HE1	GO:0047407	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	Gains
HE1	GO:0090482	vitamin transmembrane transporter activity	Gains
HE1	GO:0090422	thiamine pyrophosphate transporter activity	Gains
HE1	GO:0016160	amylase activity	Gains
HE1	GO:0050291	sphingosine N-acyltransferase activity	Gains
HE1	GO:0015562	efflux transmembrane transporter activity	Gains
HE1	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	Gains
HE1	GO:0050221	prostaglandin-E2 9-reductase activity	Gains
HE1	GO:0005214	structural constituent of chitin-based cuticle	Gains
HE1	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
HE1	GO:0015296	anion:cation symporter activity	Gains
HE1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	Gains
HE1	GO:0015631	tubulin binding	Gains
HE1	GO:0016788	hydrolase activity, acting on ester bonds	Gains
HE1	GO:0003964	RNA-directed DNA polymerase activity	Losses
HE1	GO:0034061	DNA polymerase activity	Losses
HE1	GO:0140097	catalytic activity, acting on DNA	Losses
HE1	GO:0016779	nucleotidyltransferase activity	Losses
HE1	GO:1901363	heterocyclic compound binding	Losses
HE1	GO:0097159	organic cyclic compound binding	Losses
HE1	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HE1	GO:0004190	aspartic-type endopeptidase activity	Losses
HE1	GO:0070001	aspartic-type peptidase activity	Losses
HE1	GO:0004518	nuclease activity	Losses
HE1	GO:0003676	nucleic acid binding	Losses
HE1	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
HE1	GO:0004519	endonuclease activity	Losses
HE1	GO:0004812	aminoacyl-tRNA ligase activity	Losses
HE1	GO:0140098	catalytic activity, acting on RNA	Losses
HE1	GO:0003677	DNA binding	Losses
HE1	GO:0046914	transition metal ion binding	Losses
HE1	GO:0140101	catalytic activity, acting on a tRNA	Losses
HE1	GO:0015081	sodium ion transmembrane transporter activity	Losses
HE1	GO:0022890	inorganic cation transmembrane transporter activity	Losses
HE1	GO:0004075	biotin carboxylase activity	Losses
HE1	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HE1	GO:0038023	signaling receptor activity	Losses
HE1	GO:0004983	neuropeptide Y receptor activity	Losses
HE1	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HE1	GO:0005249	voltage-gated potassium channel activity	Losses
HE1	GO:0046873	metal ion transmembrane transporter activity	Losses
HE1	GO:0008324	cation transmembrane transporter activity	Losses
HE1	GO:0003700	DNA binding transcription factor activity	Losses
HE1	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Losses
HE1	GO:0004736	pyruvate carboxylase activity	Losses
HE1	GO:0004823	leucine-tRNA ligase activity	Losses
HE1	GO:0004930	G-protein coupled receptor activity	Losses
HE1	GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
HE1	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HE1	GO:0015075	ion transmembrane transporter activity	Losses
HE1	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
HE1	GO:0004521	endoribonuclease activity	Losses
HE1	GO:0004540	ribonuclease activity	Losses
HE1	GO:0004000	adenosine deaminase activity	Losses
HE1	GO:0022857	transmembrane transporter activity	Losses
HE1	GO:0043167	ion binding	Losses
HE1	GO:0005328	neurotransmitter:sodium symporter activity	Losses
HE1	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	Losses
HE1	GO:0004828	serine-tRNA ligase activity	Losses
HE1	GO:0004658	propionyl-CoA carboxylase activity	Losses
HE1	GO:0060089	molecular transducer activity	Losses
HE1	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
HE1	GO:0004872	receptor activity	Losses
HE1	GO:0009055	electron transfer activity	Losses
HE1	GO:0050662	coenzyme binding	Losses
HE1	GO:0000155	phosphorelay sensor kinase activity	Losses
HE1	GO:0004673	protein histidine kinase activity	Losses
HE1	GO:0005507	copper ion binding	Losses
HE1	GO:0019239	deaminase activity	Losses
HE1	GO:0016491	oxidoreductase activity	Losses
HE1	GO:0048037	cofactor binding	Losses
HE1	GO:0043169	cation binding	Losses
HE1	GO:0022891	substrate-specific transmembrane transporter activity	Losses
HE1	GO:0016215	acyl-CoA desaturase activity	Losses
HE1	GO:0005451	monovalent cation:proton antiporter activity	Losses
HE1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Losses
HE1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Losses
HE1	GO:0004768	stearoyl-CoA 9-desaturase activity	Losses
HE1	GO:0004818	glutamate-tRNA ligase activity	Losses
HE1	GO:0005326	neurotransmitter transporter activity	Losses
HE1	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Losses
HE1	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
HE1	GO:0046872	metal ion binding	Losses
HE1	GO:0008270	zinc ion binding	Losses
HE1	GO:0005244	voltage-gated ion channel activity	Losses
HE1	GO:0022832	voltage-gated channel activity	Losses
HE1	GO:0019205	nucleobase-containing compound kinase activity	Losses
HE1	GO:0005272	sodium channel activity	Losses
HE1	GO:0005488	binding	Losses
HE1	GO:0022843	voltage-gated cation channel activity	Losses
HE1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
HE1	GO:0043565	sequence-specific DNA binding	Losses
HE1	GO:0030145	manganese ion binding	Losses
HE1	GO:0005506	iron ion binding	Losses
HE1	GO:0004871	signal transducer activity	Losses
HE1	GO:0004448	isocitrate dehydrogenase activity	Losses
HE1	GO:0015299	solute:proton antiporter activity	Losses
HE1	GO:0004813	alanine-tRNA ligase activity	Losses
HE1	GO:0002161	aminoacyl-tRNA editing activity	Losses
HE1	GO:0140097	catalytic activity, acting on DNA	Extinctions
HE1	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HE1	GO:0034061	DNA polymerase activity	Extinctions
HE1	GO:0016779	nucleotidyltransferase activity	Extinctions
HE1	GO:1901363	heterocyclic compound binding	Extinctions
HE1	GO:0097159	organic cyclic compound binding	Extinctions
HE1	GO:0004812	aminoacyl-tRNA ligase activity	Extinctions
HE1	GO:0140101	catalytic activity, acting on a tRNA	Extinctions
HE1	GO:0004000	adenosine deaminase activity	Extinctions
HE1	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
HE1	GO:0019239	deaminase activity	Extinctions
HE1	GO:0003676	nucleic acid binding	Extinctions
HE1	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Extinctions
HE1	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
HE1	GO:0005507	copper ion binding	Extinctions
HE1	GO:0140098	catalytic activity, acting on RNA	Extinctions
HE1	GO:0004828	serine-tRNA ligase activity	Extinctions
HE1	GO:0004658	propionyl-CoA carboxylase activity	Extinctions
HE1	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Extinctions
HE1	GO:0004818	glutamate-tRNA ligase activity	Extinctions
HE1	GO:0016885	ligase activity, forming carbon-carbon bonds	Extinctions
HE1	GO:0004075	biotin carboxylase activity	Extinctions
HE1	GO:0004448	isocitrate dehydrogenase activity	Extinctions
HE1	GO:0004813	alanine-tRNA ligase activity	Extinctions
HE1	GO:0016491	oxidoreductase activity	Extinctions
HE1	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
HE1	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Extinctions
HE1	GO:0070330	aromatase activity	Extinctions
HE1	GO:0016615	malate dehydrogenase activity	Extinctions
HE1	GO:0019205	nucleobase-containing compound kinase activity	Extinctions
HE1	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Extinctions
HE1	GO:0005506	iron ion binding	Extinctions
HE1	GO:0004518	nuclease activity	Extinctions
HE1	GO:0015002	heme-copper terminal oxidase activity	Extinctions
HE1	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
HE1	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
HE1	GO:0004129	cytochrome-c oxidase activity	Extinctions
HE1	GO:0003960	NADPH:quinone reductase activity	Extinctions
HE1	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
HE1	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
HE1	GO:0004056	argininosuccinate lyase activity	Extinctions
HE1	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
HE1	GO:0005104	fibroblast growth factor receptor binding	Extinctions
HE1	GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor	Extinctions
HE1	GO:0042586	peptide deformylase activity	Extinctions
HE1	GO:0033862	UMP kinase activity	Extinctions
HE1	GO:0050694	galactose 3-O-sulfotransferase activity	Extinctions
HE1	GO:0036400	short neuropeptide F receptor activity	Extinctions
HE1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
HE1	GO:0008829	dCTP deaminase activity	Extinctions
HE1	GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	Extinctions
HE1	GO:0042954	lipoprotein transporter activity	Extinctions
HE1	GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
HE1	GO:0004769	steroid delta-isomerase activity	Extinctions
HE1	GO:0004720	protein-lysine 6-oxidase activity	Extinctions
HE1	GO:0001733	galactosylceramide sulfotransferase activity	Extinctions
HE1	GO:0001735	prenylcysteine oxidase activity	Extinctions
HE1	GO:0036082	extracellular phenylacetaldehyde-gated ion channel activity	Extinctions
HE1	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
HE1	GO:0046914	transition metal ion binding	Extinctions
HE1	GO:0015081	sodium ion transmembrane transporter activity	Extinctions
HE1	GO:0005272	sodium channel activity	Extinctions
HE1	GO:0004519	endonuclease activity	Extinctions
HE3	GO:0008235	metalloexopeptidase activity	Gains
HE3	GO:0003954	NADH dehydrogenase activity	Gains
HE3	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
HE3	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
HE3	GO:0004950	chemokine receptor activity	Gains
HE3	GO:0050136	NADH dehydrogenase (quinone) activity	Gains
HE3	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Gains
HE3	GO:0004896	cytokine receptor activity	Gains
HE3	GO:0016491	oxidoreductase activity	Gains
HE3	GO:0019104	DNA N-glycosylase activity	Gains
HE3	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
HE3	GO:0020037	heme binding	Gains
HE3	GO:0046906	tetrapyrrole binding	Gains
HE3	GO:0071855	neuropeptide receptor binding	Gains
HE3	GO:0016209	antioxidant activity	Gains
HE3	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
HE3	GO:0016615	malate dehydrogenase activity	Gains
HE3	GO:0004722	protein serine/threonine phosphatase activity	Gains
HE3	GO:0016831	carboxy-lyase activity	Gains
HE3	GO:0015081	sodium ion transmembrane transporter activity	Gains
HE3	GO:0015296	anion:cation symporter activity	Gains
HE3	GO:0005272	sodium channel activity	Gains
HE3	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Gains
HE3	GO:0004351	glutamate decarboxylase activity	Gains
HE3	GO:0043733	DNA-3-methylbase glycosylase activity	Gains
HE3	GO:0050080	malonyl-CoA decarboxylase activity	Gains
HE3	GO:0008725	DNA-3-methyladenine glycosylase activity	Gains
HE3	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Gains
HE3	GO:0004157	dihydropyrimidinase activity	Gains
HE3	GO:0008836	diaminopimelate decarboxylase activity	Gains
HE3	GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	Gains
HE3	GO:0008511	sodium:potassium:chloride symporter activity	Gains
HE3	GO:0008515	sucrose transmembrane transporter activity	Gains
HE3	GO:0004782	sulfinoalanine decarboxylase activity	Gains
HE3	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	Gains
HE3	GO:0016751	S-succinyltransferase activity	Gains
HE3	GO:0004586	ornithine decarboxylase activity	Gains
HE3	GO:0043916	DNA-7-methylguanine glycosylase activity	Gains
HE3	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
HE3	GO:0004507	steroid 11-beta-monooxygenase activity	Gains
HE3	GO:0003905	alkylbase DNA N-glycosylase activity	Gains
HE3	GO:0004642	phosphoribosylformylglycinamidine synthase activity	Gains
HE3	GO:0000700	mismatch base pair DNA N-glycosylase activity	Gains
HE3	GO:0030586	[methionine synthase] reductase activity	Gains
HE3	GO:0004096	catalase activity	Gains
HE3	GO:0004068	aspartate 1-decarboxylase activity	Gains
HE3	GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
HE3	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
HE3	GO:0052821	DNA-7-methyladenine glycosylase activity	Gains
HE3	GO:0052822	DNA-3-methylguanine glycosylase activity	Gains
HE3	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Gains
HE3	GO:0005415	nucleoside:sodium symporter activity	Gains
HE3	GO:0004397	histidine ammonia-lyase activity	Gains
HE3	GO:0004601	peroxidase activity	Gains
HE3	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
HE3	GO:0008237	metallopeptidase activity	Gains
HE3	GO:0015294	solute:cation symporter activity	Gains
HE3	GO:0004866	endopeptidase inhibitor activity	Gains
HE3	GO:0003964	RNA-directed DNA polymerase activity	Losses
HE3	GO:0034061	DNA polymerase activity	Losses
HE3	GO:0016779	nucleotidyltransferase activity	Losses
HE3	GO:0140097	catalytic activity, acting on DNA	Losses
HE3	GO:0046914	transition metal ion binding	Losses
HE3	GO:0003676	nucleic acid binding	Losses
HE3	GO:0008270	zinc ion binding	Losses
HE3	GO:0003677	DNA binding	Losses
HE3	GO:0004519	endonuclease activity	Losses
HE3	GO:0046872	metal ion binding	Losses
HE3	GO:0043169	cation binding	Losses
HE3	GO:0031267	small GTPase binding	Losses
HE3	GO:0004518	nuclease activity	Losses
HE3	GO:0017016	Ras GTPase binding	Losses
HE3	GO:0017137	Rab GTPase binding	Losses
HE3	GO:0051020	GTPase binding	Losses
HE3	GO:0043015	gamma-tubulin binding	Losses
HE3	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
HE3	GO:0004629	phospholipase C activity	Losses
HE3	GO:1901363	heterocyclic compound binding	Losses
HE3	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HE3	GO:0097159	organic cyclic compound binding	Losses
HE3	GO:0015085	calcium ion transmembrane transporter activity	Losses
HE3	GO:0070001	aspartic-type peptidase activity	Losses
HE3	GO:0004190	aspartic-type endopeptidase activity	Losses
HE3	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
HE3	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
HE3	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
HE3	GO:0005262	calcium channel activity	Losses
HE3	GO:0008172	S-methyltransferase activity	Losses
HE3	GO:0034062	5'-3' RNA polymerase activity	Losses
HE3	GO:0097747	RNA polymerase activity	Losses
HE3	GO:0004984	olfactory receptor activity	Losses
HE3	GO:0005488	binding	Losses
HE3	GO:0005549	odorant binding	Losses
HE3	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HE3	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
HE3	GO:0005245	voltage-gated calcium channel activity	Losses
HE3	GO:0004521	endoribonuclease activity	Losses
HE3	GO:0004185	serine-type carboxypeptidase activity	Losses
HE3	GO:0017034	Rap guanyl-nucleotide exchange factor activity	Losses
HE3	GO:0008525	phosphatidylcholine transporter activity	Losses
HE3	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	Losses
HE3	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Losses
HE3	GO:0050824	water binding	Losses
HE3	GO:0050825	ice binding	Losses
HE3	GO:0016906	sterol 3-beta-glucosyltransferase activity	Losses
HE3	GO:0048365	Rac GTPase binding	Losses
HE3	GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
HE3	GO:0016769	transferase activity, transferring nitrogenous groups	Losses
HE3	GO:0008483	transaminase activity	Losses
HE3	GO:0004857	enzyme inhibitor activity	Losses
HE3	GO:0019899	enzyme binding	Losses
HE3	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
HE3	GO:0046906	tetrapyrrole binding	Losses
HE3	GO:0005506	iron ion binding	Losses
HE3	GO:0015631	tubulin binding	Losses
HE3	GO:0042302	structural constituent of cuticle	Losses
HE3	GO:0004497	monooxygenase activity	Losses
HE3	GO:0019842	vitamin binding	Losses
HE3	GO:0030414	peptidase inhibitor activity	Losses
HE3	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
HE3	GO:0061134	peptidase regulator activity	Losses
HE3	GO:0003678	DNA helicase activity	Losses
HE3	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
HE3	GO:0020037	heme binding	Losses
HE3	GO:0003676	nucleic acid binding	Extinctions
HE3	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HE3	GO:0016779	nucleotidyltransferase activity	Extinctions
HE3	GO:0034061	DNA polymerase activity	Extinctions
HE3	GO:0003677	DNA binding	Extinctions
HE3	GO:0008270	zinc ion binding	Extinctions
HE3	GO:0046914	transition metal ion binding	Extinctions
HE3	GO:1901363	heterocyclic compound binding	Extinctions
HE3	GO:0097159	organic cyclic compound binding	Extinctions
HE3	GO:0140097	catalytic activity, acting on DNA	Extinctions
HE3	GO:0004984	olfactory receptor activity	Extinctions
HE3	GO:0004519	endonuclease activity	Extinctions
HE3	GO:0004518	nuclease activity	Extinctions
HE3	GO:0004857	enzyme inhibitor activity	Extinctions
HE3	GO:0034062	5'-3' RNA polymerase activity	Extinctions
HE3	GO:0097747	RNA polymerase activity	Extinctions
HE3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
HE3	GO:0008527	taste receptor activity	Extinctions
HE3	GO:0043015	gamma-tubulin binding	Extinctions
HE3	GO:0005184	neuropeptide hormone activity	Extinctions
HE3	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
HE3	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
HE3	GO:0005549	odorant binding	Extinctions
HE3	GO:0017137	Rab GTPase binding	Extinctions
HE3	GO:0070001	aspartic-type peptidase activity	Extinctions
HE3	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HE3	GO:0051427	hormone receptor binding	Extinctions
HE3	GO:0005179	hormone activity	Extinctions
HE3	GO:0030291	protein serine/threonine kinase inhibitor activity	Extinctions
HE3	GO:0061134	peptidase regulator activity	Extinctions
HE3	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
PHUMA	GO:0004984	olfactory receptor activity	Gains
PHUMA	GO:0008066	glutamate receptor activity	Gains
PHUMA	GO:0005549	odorant binding	Gains
PHUMA	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
PHUMA	GO:0004950	chemokine receptor activity	Gains
PHUMA	GO:0004970	ionotropic glutamate receptor activity	Gains
PHUMA	GO:0022824	transmitter-gated ion channel activity	Gains
PHUMA	GO:0022835	transmitter-gated channel activity	Gains
PHUMA	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
PHUMA	GO:0005230	extracellular ligand-gated ion channel activity	Gains
PHUMA	GO:0015267	channel activity	Gains
PHUMA	GO:0022803	passive transmembrane transporter activity	Gains
PHUMA	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
PHUMA	GO:0005216	ion channel activity	Gains
PHUMA	GO:0004896	cytokine receptor activity	Gains
PHUMA	GO:0022838	substrate-specific channel activity	Gains
PHUMA	GO:0004930	G-protein coupled receptor activity	Gains
PHUMA	GO:0016215	acyl-CoA desaturase activity	Gains
PHUMA	GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
PHUMA	GO:0015276	ligand-gated ion channel activity	Gains
PHUMA	GO:0022834	ligand-gated channel activity	Gains
PHUMA	GO:0004129	cytochrome-c oxidase activity	Gains
PHUMA	GO:0015002	heme-copper terminal oxidase activity	Gains
PHUMA	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
PHUMA	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
PHUMA	GO:0004872	receptor activity	Gains
PHUMA	GO:0060089	molecular transducer activity	Gains
PHUMA	GO:0030594	neurotransmitter receptor activity	Gains
PHUMA	GO:0003964	RNA-directed DNA polymerase activity	Losses
PHUMA	GO:0034061	DNA polymerase activity	Losses
PHUMA	GO:0140097	catalytic activity, acting on DNA	Losses
PHUMA	GO:0016779	nucleotidyltransferase activity	Losses
PHUMA	GO:0004190	aspartic-type endopeptidase activity	Losses
PHUMA	GO:0070001	aspartic-type peptidase activity	Losses
PHUMA	GO:0004519	endonuclease activity	Losses
PHUMA	GO:0046914	transition metal ion binding	Losses
PHUMA	GO:0042834	peptidoglycan binding	Losses
PHUMA	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
PHUMA	GO:0004872	receptor activity	Losses
PHUMA	GO:0043169	cation binding	Losses
PHUMA	GO:0004175	endopeptidase activity	Losses
PHUMA	GO:0046872	metal ion binding	Losses
PHUMA	GO:0008270	zinc ion binding	Losses
PHUMA	GO:0004518	nuclease activity	Losses
PHUMA	GO:0038023	signaling receptor activity	Losses
PHUMA	GO:0042302	structural constituent of cuticle	Losses
PHUMA	GO:0016787	hydrolase activity	Losses
PHUMA	GO:0060089	molecular transducer activity	Losses
PHUMA	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
PHUMA	GO:0004629	phospholipase C activity	Losses
PHUMA	GO:0005214	structural constituent of chitin-based cuticle	Losses
PHUMA	GO:0003676	nucleic acid binding	Losses
PHUMA	GO:0016788	hydrolase activity, acting on ester bonds	Losses
PHUMA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
PHUMA	GO:0004871	signal transducer activity	Losses
PHUMA	GO:0008233	peptidase activity	Losses
PHUMA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
PHUMA	GO:0005549	odorant binding	Losses
PHUMA	GO:0003723	RNA binding	Losses
PHUMA	GO:0099600	transmembrane receptor activity	Losses
PHUMA	GO:0005539	glycosaminoglycan binding	Losses
PHUMA	GO:0004521	endoribonuclease activity	Losses
PHUMA	GO:0001530	lipopolysaccharide binding	Losses
PHUMA	GO:0008329	signaling pattern recognition receptor activity	Losses
PHUMA	GO:0038187	pattern recognition receptor activity	Losses
PHUMA	GO:0003990	acetylcholinesterase activity	Losses
PHUMA	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
PHUMA	GO:0004888	transmembrane signaling receptor activity	Losses
PHUMA	GO:0004104	cholinesterase activity	Losses
PHUMA	GO:0004803	transposase activity	Losses
PHUMA	GO:0003678	DNA helicase activity	Losses
PHUMA	GO:0008527	taste receptor activity	Losses
PHUMA	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
PHUMA	GO:0009881	photoreceptor activity	Losses
PHUMA	GO:0009378	four-way junction helicase activity	Losses
PHUMA	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
PHUMA	GO:0016531	copper chaperone activity	Losses
PHUMA	GO:0001872	(1->3)-beta-D-glucan binding	Losses
PHUMA	GO:0003913	DNA photolyase activity	Losses
PHUMA	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
PHUMA	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
PHUMA	GO:0004930	G-protein coupled receptor activity	Losses
PHUMA	GO:0019840	isoprenoid binding	Losses
PHUMA	GO:0016755	transferase activity, transferring amino-acyl groups	Losses
PHUMA	GO:0003677	DNA binding	Losses
PHUMA	GO:0016829	lyase activity	Losses
PHUMA	GO:0042910	xenobiotic transmembrane transporter activity	Losses
PHUMA	GO:0005272	sodium channel activity	Losses
PHUMA	GO:0005506	iron ion binding	Losses
PHUMA	GO:0046592	polyamine oxidase activity	Losses
PHUMA	GO:0070891	lipoteichoic acid binding	Losses
PHUMA	GO:0030882	lipid antigen binding	Losses
PHUMA	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Losses
PHUMA	GO:0035197	siRNA binding	Losses
PHUMA	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
PHUMA	GO:0016530	metallochaperone activity	Losses
PHUMA	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
PHUMA	GO:0004089	carbonate dehydratase activity	Losses
PHUMA	GO:0004386	helicase activity	Losses
PHUMA	GO:0030246	carbohydrate binding	Losses
PHUMA	GO:0016836	hydro-lyase activity	Losses
PHUMA	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
PHUMA	GO:0003713	transcription coactivator activity	Losses
PHUMA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
PHUMA	GO:0016917	GABA receptor activity	Losses
PHUMA	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
PHUMA	GO:0003823	antigen binding	Losses
PHUMA	GO:0043548	phosphatidylinositol 3-kinase binding	Losses
PHUMA	GO:0004736	pyruvate carboxylase activity	Losses
PHUMA	GO:0005501	retinoid binding	Losses
PHUMA	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
PHUMA	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
PHUMA	GO:0004540	ribonuclease activity	Losses
PHUMA	GO:0004984	olfactory receptor activity	Losses
PHUMA	GO:1901363	heterocyclic compound binding	Losses
PHUMA	GO:0004620	phospholipase activity	Losses
PHUMA	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
PHUMA	GO:0034061	DNA polymerase activity	Extinctions
PHUMA	GO:0140097	catalytic activity, acting on DNA	Extinctions
PHUMA	GO:0016779	nucleotidyltransferase activity	Extinctions
PHUMA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
PHUMA	GO:0070001	aspartic-type peptidase activity	Extinctions
PHUMA	GO:0003676	nucleic acid binding	Extinctions
PHUMA	GO:0046914	transition metal ion binding	Extinctions
PHUMA	GO:0008270	zinc ion binding	Extinctions
PHUMA	GO:0043169	cation binding	Extinctions
PHUMA	GO:0042834	peptidoglycan binding	Extinctions
PHUMA	GO:0046872	metal ion binding	Extinctions
PHUMA	GO:0004175	endopeptidase activity	Extinctions
PHUMA	GO:0003677	DNA binding	Extinctions
PHUMA	GO:0003678	DNA helicase activity	Extinctions
PHUMA	GO:0003723	RNA binding	Extinctions
PHUMA	GO:0001530	lipopolysaccharide binding	Extinctions
PHUMA	GO:0004803	transposase activity	Extinctions
PHUMA	GO:0004519	endonuclease activity	Extinctions
PHUMA	GO:0009378	four-way junction helicase activity	Extinctions
PHUMA	GO:0016531	copper chaperone activity	Extinctions
PHUMA	GO:0004518	nuclease activity	Extinctions
PHUMA	GO:0005272	sodium channel activity	Extinctions
PHUMA	GO:0004386	helicase activity	Extinctions
PHUMA	GO:0070891	lipoteichoic acid binding	Extinctions
PHUMA	GO:0030882	lipid antigen binding	Extinctions
PHUMA	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
PHUMA	GO:0016530	metallochaperone activity	Extinctions
PHUMA	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Extinctions
PHUMA	GO:0016787	hydrolase activity	Extinctions
PHUMA	GO:0008233	peptidase activity	Extinctions
PHUMA	GO:1901363	heterocyclic compound binding	Extinctions
PHUMA	GO:0097159	organic cyclic compound binding	Extinctions
PHUMA	GO:0004435	phosphatidylinositol phospholipase C activity	Extinctions
PHUMA	GO:0004629	phospholipase C activity	Extinctions
PHUMA	GO:0003823	antigen binding	Extinctions
PHUMA	GO:0004736	pyruvate carboxylase activity	Extinctions
PHUMA	GO:0005501	retinoid binding	Extinctions
PHUMA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
PHUMA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
PHUMA	GO:0005549	odorant binding	Extinctions
PHUMA	GO:0008527	taste receptor activity	Extinctions
PHUMA	GO:0004784	superoxide dismutase activity	Extinctions
PHUMA	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Extinctions
PHUMA	GO:0009008	DNA-methyltransferase activity	Extinctions
PHUMA	GO:0003713	transcription coactivator activity	Extinctions
PHUMA	GO:0005506	iron ion binding	Extinctions
PHUMA	GO:0005539	glycosaminoglycan binding	Extinctions
PHUMA	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
LFULV	GO:0003964	RNA-directed DNA polymerase activity	Gains
LFULV	GO:0034061	DNA polymerase activity	Gains
LFULV	GO:0140097	catalytic activity, acting on DNA	Gains
LFULV	GO:0016779	nucleotidyltransferase activity	Gains
LFULV	GO:0008270	zinc ion binding	Gains
LFULV	GO:0046914	transition metal ion binding	Gains
LFULV	GO:0004190	aspartic-type endopeptidase activity	Gains
LFULV	GO:0070001	aspartic-type peptidase activity	Gains
LFULV	GO:0003676	nucleic acid binding	Gains
LFULV	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
LFULV	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
LFULV	GO:0004519	endonuclease activity	Gains
LFULV	GO:0046872	metal ion binding	Gains
LFULV	GO:0043169	cation binding	Gains
LFULV	GO:0004518	nuclease activity	Gains
LFULV	GO:0097159	organic cyclic compound binding	Gains
LFULV	GO:1901363	heterocyclic compound binding	Gains
LFULV	GO:0003677	DNA binding	Gains
LFULV	GO:0005488	binding	Gains
LFULV	GO:0003723	RNA binding	Gains
LFULV	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
LFULV	GO:0015370	solute:sodium symporter activity	Gains
LFULV	GO:0022836	gated channel activity	Gains
LFULV	GO:0008234	cysteine-type peptidase activity	Gains
LFULV	GO:0035197	siRNA binding	Gains
LFULV	GO:0047134	protein-disulfide reductase activity	Gains
LFULV	GO:0035586	purinergic receptor activity	Gains
LFULV	GO:0004803	transposase activity	Gains
LFULV	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
LFULV	GO:0022838	substrate-specific channel activity	Gains
LFULV	GO:0003777	microtubule motor activity	Gains
LFULV	GO:0015267	channel activity	Gains
LFULV	GO:0022803	passive transmembrane transporter activity	Gains
LFULV	GO:0022832	voltage-gated channel activity	Gains
LFULV	GO:0005244	voltage-gated ion channel activity	Gains
LFULV	GO:0051020	GTPase binding	Gains
LFULV	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
LFULV	GO:0015294	solute:cation symporter activity	Gains
LFULV	GO:0005216	ion channel activity	Gains
LFULV	GO:0005509	calcium ion binding	Gains
LFULV	GO:0015291	secondary active transmembrane transporter activity	Gains
LFULV	GO:0003725	double-stranded RNA binding	Gains
LFULV	GO:0008233	peptidase activity	Gains
LFULV	GO:0015293	symporter activity	Gains
LFULV	GO:0005096	GTPase activator activity	Gains
LFULV	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
LFULV	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
LFULV	GO:0016740	transferase activity	Gains
LFULV	GO:0005328	neurotransmitter:sodium symporter activity	Gains
LFULV	GO:0031267	small GTPase binding	Gains
LFULV	GO:0016849	phosphorus-oxygen lyase activity	Gains
LFULV	GO:0017137	Rab GTPase binding	Gains
LFULV	GO:0043167	ion binding	Gains
LFULV	GO:0015171	amino acid transmembrane transporter activity	Gains
LFULV	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
LFULV	GO:0019825	oxygen binding	Gains
LFULV	GO:0004016	adenylate cyclase activity	Gains
LFULV	GO:0005253	anion channel activity	Gains
LFULV	GO:0004521	endoribonuclease activity	Gains
LFULV	GO:0042302	structural constituent of cuticle	Gains
LFULV	GO:0030429	kynureninase activity	Gains
LFULV	GO:0016906	sterol 3-beta-glucosyltransferase activity	Gains
LFULV	GO:0070548	L-glutamine aminotransferase activity	Gains
LFULV	GO:0003689	DNA clamp loader activity	Gains
LFULV	GO:0005212	structural constituent of eye lens	Gains
LFULV	GO:0016781	phosphotransferase activity, paired acceptors	Gains
LFULV	GO:0043546	molybdopterin cofactor binding	Gains
LFULV	GO:0016882	cyclo-ligase activity	Gains
LFULV	GO:0004837	tyrosine decarboxylase activity	Gains
LFULV	GO:0001729	ceramide kinase activity	Gains
LFULV	GO:0033170	protein-DNA loading ATPase activity	Gains
LFULV	GO:0016502	nucleotide receptor activity	Gains
LFULV	GO:0004689	phosphorylase kinase activity	Gains
LFULV	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
LFULV	GO:0001614	purinergic nucleotide receptor activity	Gains
LFULV	GO:0004019	adenylosuccinate synthase activity	Gains
LFULV	GO:0031386	protein tag	Gains
LFULV	GO:0060089	molecular transducer activity	Losses
LFULV	GO:0099600	transmembrane receptor activity	Losses
LFULV	GO:0004872	receptor activity	Losses
LFULV	GO:0004888	transmembrane signaling receptor activity	Losses
LFULV	GO:0004871	signal transducer activity	Losses
LFULV	GO:0038023	signaling receptor activity	Losses
LFULV	GO:0005549	odorant binding	Losses
LFULV	GO:0004930	G-protein coupled receptor activity	Losses
LFULV	GO:0003990	acetylcholinesterase activity	Losses
LFULV	GO:0004104	cholinesterase activity	Losses
LFULV	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
LFULV	GO:0008527	taste receptor activity	Losses
LFULV	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
LFULV	GO:0061783	peptidoglycan muralytic activity	Losses
LFULV	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
LFULV	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Losses
LFULV	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
LFULV	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
LFULV	GO:0015408	ferric-transporting ATPase activity	Losses
LFULV	GO:0008484	sulfuric ester hydrolase activity	Losses
LFULV	GO:0003796	lysozyme activity	Losses
LFULV	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Losses
LFULV	GO:0015091	ferric iron transmembrane transporter activity	Losses
LFULV	GO:0015605	organophosphate ester transmembrane transporter activity	Losses
LFULV	GO:0008066	glutamate receptor activity	Losses
LFULV	GO:0004620	phospholipase activity	Losses
LFULV	GO:0004857	enzyme inhibitor activity	Losses
LFULV	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
LFULV	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Losses
LFULV	GO:0005381	iron ion transmembrane transporter activity	Losses
LFULV	GO:0015604	organic phosphonate transmembrane transporter activity	Losses
LFULV	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Losses
LFULV	GO:0016829	lyase activity	Losses
LFULV	GO:0008081	phosphoric diester hydrolase activity	Losses
LFULV	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
LFULV	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
LFULV	GO:0004745	retinol dehydrogenase activity	Losses
LFULV	GO:0016842	amidine-lyase activity	Losses
LFULV	GO:0003978	UDP-glucose 4-epimerase activity	Losses
LFULV	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
LFULV	GO:0016298	lipase activity	Losses
LFULV	GO:0005201	extracellular matrix structural constituent	Losses
LFULV	GO:0030414	peptidase inhibitor activity	Losses
LFULV	GO:0008509	anion transmembrane transporter activity	Losses
LFULV	GO:0016840	carbon-nitrogen lyase activity	Losses
LFULV	GO:0032561	guanyl ribonucleotide binding	Losses
LFULV	GO:0019001	guanyl nucleotide binding	Losses
LFULV	GO:0008329	signaling pattern recognition receptor activity	Losses
LFULV	GO:0003896	DNA primase activity	Losses
LFULV	GO:0005251	delayed rectifier potassium channel activity	Losses
LFULV	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Losses
LFULV	GO:0038187	pattern recognition receptor activity	Losses
LFULV	GO:0005525	GTP binding	Losses
LFULV	GO:0032550	purine ribonucleoside binding	Losses
LFULV	GO:0001883	purine nucleoside binding	Losses
LFULV	GO:0004000	adenosine deaminase activity	Losses
LFULV	GO:0022857	transmembrane transporter activity	Losses
LFULV	GO:0016787	hydrolase activity	Losses
LFULV	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
LFULV	GO:0061134	peptidase regulator activity	Losses
LFULV	GO:0005215	transporter activity	Losses
LFULV	GO:0032549	ribonucleoside binding	Losses
LFULV	GO:0019239	deaminase activity	Losses
LFULV	GO:0042578	phosphoric ester hydrolase activity	Losses
LFULV	GO:0030247	polysaccharide binding	Losses
LFULV	GO:0016854	racemase and epimerase activity	Losses
LFULV	GO:0015926	glucosidase activity	Losses
LFULV	GO:0001871	pattern binding	Losses
LFULV	GO:0001882	nucleoside binding	Losses
LFULV	GO:0008061	chitin binding	Losses
LFULV	GO:0015276	ligand-gated ion channel activity	Losses
LFULV	GO:0022834	ligand-gated channel activity	Losses
LFULV	GO:0052689	carboxylic ester hydrolase activity	Losses
LFULV	GO:0022891	substrate-specific transmembrane transporter activity	Losses
LFULV	GO:0005216	ion channel activity	Losses
LFULV	GO:0022838	substrate-specific channel activity	Losses
LFULV	GO:0042834	peptidoglycan binding	Losses
LFULV	GO:0005544	calcium-dependent phospholipid binding	Losses
LFULV	GO:0042169	SH2 domain binding	Losses
LFULV	GO:0004965	G-protein coupled GABA receptor activity	Losses
LFULV	GO:0015075	ion transmembrane transporter activity	Losses
LFULV	GO:0005549	odorant binding	Extinctions
LFULV	GO:0008527	taste receptor activity	Extinctions
LFULV	GO:0099600	transmembrane receptor activity	Extinctions
LFULV	GO:0004888	transmembrane signaling receptor activity	Extinctions
LFULV	GO:0004930	G-protein coupled receptor activity	Extinctions
LFULV	GO:0038023	signaling receptor activity	Extinctions
LFULV	GO:0004871	signal transducer activity	Extinctions
LFULV	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Extinctions
LFULV	GO:0008066	glutamate receptor activity	Extinctions
LFULV	GO:0008081	phosphoric diester hydrolase activity	Extinctions
LFULV	GO:0003896	DNA primase activity	Extinctions
LFULV	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Extinctions
LFULV	GO:0004857	enzyme inhibitor activity	Extinctions
LFULV	GO:0004872	receptor activity	Extinctions
LFULV	GO:0015408	ferric-transporting ATPase activity	Extinctions
LFULV	GO:0008484	sulfuric ester hydrolase activity	Extinctions
LFULV	GO:0003796	lysozyme activity	Extinctions
LFULV	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Extinctions
LFULV	GO:0015091	ferric iron transmembrane transporter activity	Extinctions
LFULV	GO:0008061	chitin binding	Extinctions
LFULV	GO:0005201	extracellular matrix structural constituent	Extinctions
LFULV	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
LFULV	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
LFULV	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Extinctions
LFULV	GO:0042578	phosphoric ester hydrolase activity	Extinctions
LFULV	GO:0060089	molecular transducer activity	Extinctions
LFULV	GO:0030414	peptidase inhibitor activity	Extinctions
LFULV	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Extinctions
LFULV	GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
LFULV	GO:0005007	fibroblast growth factor-activated receptor activity	Extinctions
LFULV	GO:0050897	cobalt ion binding	Extinctions
LFULV	GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
LFULV	GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
LFULV	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
LFULV	GO:0008428	ribonuclease inhibitor activity	Extinctions
LFULV	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
LFULV	GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
LFULV	GO:0018580	nitronate monooxygenase activity	Extinctions
LFULV	GO:0003720	telomerase activity	Extinctions
LFULV	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
LFULV	GO:0004423	iduronate-2-sulfatase activity	Extinctions
LFULV	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
LFULV	GO:0008226	tyramine receptor activity	Extinctions
LFULV	GO:0033981	D-dopachrome decarboxylase activity	Extinctions
LFULV	GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
LFULV	GO:0033971	hydroxyisourate hydrolase activity	Extinctions
LFULV	GO:0008728	GTP diphosphokinase activity	Extinctions
LFULV	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Extinctions
LFULV	GO:0000156	phosphorelay response regulator activity	Extinctions
LFULV	GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
LFULV	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
LFULV	GO:0008816	citryl-CoA lyase activity	Extinctions
LFULV	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
LFULV	GO:0016794	diphosphoric monoester hydrolase activity	Extinctions
LFULV	GO:0004769	steroid delta-isomerase activity	Extinctions
LFULV	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
LFULV	GO:0017159	pantetheine hydrolase activity	Extinctions
LFULV	GO:0015098	molybdate ion transmembrane transporter activity	Extinctions
LFULV	GO:0005550	pheromone binding	Extinctions
LFULV	GO:0003941	L-serine ammonia-lyase activity	Extinctions
LFULV	GO:0032542	sulfiredoxin activity	Extinctions
LFULV	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Extinctions
LFULV	GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
LFULV	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
LFULV	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
LFULV	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
LFULV	GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
LFULV	GO:0004056	argininosuccinate lyase activity	Extinctions
LFULV	GO:0004038	allantoinase activity	Extinctions
LFULV	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Extinctions
LFULV	GO:1990939	ATP-dependent microtubule motor activity	Extinctions
LFULV	GO:0030165	PDZ domain binding	Extinctions
LFULV	GO:0005381	iron ion transmembrane transporter activity	Extinctions
LFULV	GO:0015604	organic phosphonate transmembrane transporter activity	Extinctions
DPULE	GO:0003964	RNA-directed DNA polymerase activity	Gains
DPULE	GO:0070001	aspartic-type peptidase activity	Gains
DPULE	GO:0004190	aspartic-type endopeptidase activity	Gains
DPULE	GO:0008270	zinc ion binding	Gains
DPULE	GO:0034061	DNA polymerase activity	Gains
DPULE	GO:0046914	transition metal ion binding	Gains
DPULE	GO:0004175	endopeptidase activity	Gains
DPULE	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DPULE	GO:0008233	peptidase activity	Gains
DPULE	GO:0003676	nucleic acid binding	Gains
DPULE	GO:0004888	transmembrane signaling receptor activity	Gains
DPULE	GO:0022824	transmitter-gated ion channel activity	Gains
DPULE	GO:0022835	transmitter-gated channel activity	Gains
DPULE	GO:0004970	ionotropic glutamate receptor activity	Gains
DPULE	GO:0008066	glutamate receptor activity	Gains
DPULE	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
DPULE	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DPULE	GO:0140097	catalytic activity, acting on DNA	Gains
DPULE	GO:0099600	transmembrane receptor activity	Gains
DPULE	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
DPULE	GO:0038023	signaling receptor activity	Gains
DPULE	GO:0030594	neurotransmitter receptor activity	Gains
DPULE	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
DPULE	GO:0004521	endoribonuclease activity	Gains
DPULE	GO:0008378	galactosyltransferase activity	Gains
DPULE	GO:0004872	receptor activity	Gains
DPULE	GO:0004252	serine-type endopeptidase activity	Gains
DPULE	GO:0060089	molecular transducer activity	Gains
DPULE	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DPULE	GO:0016779	nucleotidyltransferase activity	Gains
DPULE	GO:0004519	endonuclease activity	Gains
DPULE	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
DPULE	GO:0004984	olfactory receptor activity	Gains
DPULE	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
DPULE	GO:0004518	nuclease activity	Gains
DPULE	GO:0042302	structural constituent of cuticle	Gains
DPULE	GO:0046872	metal ion binding	Gains
DPULE	GO:0043169	cation binding	Gains
DPULE	GO:0017171	serine hydrolase activity	Gains
DPULE	GO:0030246	carbohydrate binding	Gains
DPULE	GO:0015276	ligand-gated ion channel activity	Gains
DPULE	GO:0022834	ligand-gated channel activity	Gains
DPULE	GO:0030414	peptidase inhibitor activity	Gains
DPULE	GO:0004930	G-protein coupled receptor activity	Gains
DPULE	GO:0004871	signal transducer activity	Gains
DPULE	GO:0005549	odorant binding	Gains
DPULE	GO:0008236	serine-type peptidase activity	Gains
DPULE	GO:0004540	ribonuclease activity	Gains
DPULE	GO:0004803	transposase activity	Gains
DPULE	GO:0031409	pigment binding	Gains
DPULE	GO:0008061	chitin binding	Gains
DPULE	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
DPULE	GO:0061134	peptidase regulator activity	Gains
DPULE	GO:0004312	fatty acid synthase activity	Gains
DPULE	GO:1901363	heterocyclic compound binding	Gains
DPULE	GO:0097159	organic cyclic compound binding	Gains
DPULE	GO:0016209	antioxidant activity	Gains
DPULE	GO:0004104	cholinesterase activity	Gains
DPULE	GO:0005215	transporter activity	Gains
DPULE	GO:0035250	UDP-galactosyltransferase activity	Gains
DPULE	GO:0004857	enzyme inhibitor activity	Gains
DPULE	GO:0004601	peroxidase activity	Gains
DPULE	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
DPULE	GO:0003990	acetylcholinesterase activity	Gains
DPULE	GO:0003678	DNA helicase activity	Gains
DPULE	GO:0046906	tetrapyrrole binding	Gains
DPULE	GO:0019825	oxygen binding	Gains
DPULE	GO:0001871	pattern binding	Gains
DPULE	GO:0030247	polysaccharide binding	Gains
DPULE	GO:0052689	carboxylic ester hydrolase activity	Gains
DPULE	GO:0020037	heme binding	Gains
DPULE	GO:0008234	cysteine-type peptidase activity	Gains
DPULE	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DPULE	GO:0015232	heme transporter activity	Gains
DPULE	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
DPULE	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DPULE	GO:0008527	taste receptor activity	Gains
DPULE	GO:0031543	peptidyl-proline dioxygenase activity	Gains
DPULE	GO:0005344	oxygen carrier activity	Gains
DPULE	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
DPULE	GO:0004806	triglyceride lipase activity	Gains
DPULE	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
DPULE	GO:0016229	steroid dehydrogenase activity	Gains
DPULE	GO:0005213	structural constituent of chorion	Gains
DPULE	GO:0000182	rDNA binding	Gains
DPULE	GO:0004798	thymidylate kinase activity	Gains
DPULE	GO:0004555	alpha,alpha-trehalase activity	Gains
DPULE	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
DPULE	GO:0001872	(1->3)-beta-D-glucan binding	Gains
DPULE	GO:0008020	G-protein coupled photoreceptor activity	Gains
DPULE	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
DPULE	GO:0043874	acireductone synthase activity	Gains
DPULE	GO:0015927	trehalase activity	Gains
DPULE	GO:0005199	structural constituent of cell wall	Gains
DPULE	GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	Gains
DPULE	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	Gains
DPULE	GO:0016630	protochlorophyllide reductase activity	Gains
DPULE	GO:0022836	gated channel activity	Losses
DPULE	GO:0022838	substrate-specific channel activity	Losses
DPULE	GO:0015267	channel activity	Losses
DPULE	GO:0022803	passive transmembrane transporter activity	Losses
DPULE	GO:0005216	ion channel activity	Losses
DPULE	GO:0005261	cation channel activity	Losses
DPULE	GO:0046873	metal ion transmembrane transporter activity	Losses
DPULE	GO:0099094	ligand-gated cation channel activity	Losses
DPULE	GO:0005227	calcium activated cation channel activity	Losses
DPULE	GO:0022890	inorganic cation transmembrane transporter activity	Losses
DPULE	GO:0015079	potassium ion transmembrane transporter activity	Losses
DPULE	GO:0016791	phosphatase activity	Losses
DPULE	GO:0022839	ion gated channel activity	Losses
DPULE	GO:0099600	transmembrane receptor activity	Losses
DPULE	GO:0004721	phosphoprotein phosphatase activity	Losses
DPULE	GO:0005267	potassium channel activity	Losses
DPULE	GO:0015276	ligand-gated ion channel activity	Losses
DPULE	GO:0022834	ligand-gated channel activity	Losses
DPULE	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
DPULE	GO:0004950	chemokine receptor activity	Losses
DPULE	GO:0022857	transmembrane transporter activity	Losses
DPULE	GO:0004871	signal transducer activity	Losses
DPULE	GO:0022891	substrate-specific transmembrane transporter activity	Losses
DPULE	GO:0005230	extracellular ligand-gated ion channel activity	Losses
DPULE	GO:0004888	transmembrane signaling receptor activity	Losses
DPULE	GO:0008484	sulfuric ester hydrolase activity	Losses
DPULE	GO:0022892	substrate-specific transporter activity	Losses
DPULE	GO:0008324	cation transmembrane transporter activity	Losses
DPULE	GO:0060089	molecular transducer activity	Losses
DPULE	GO:0140096	catalytic activity, acting on a protein	Losses
DPULE	GO:0005310	dicarboxylic acid transmembrane transporter activity	Losses
DPULE	GO:0004896	cytokine receptor activity	Losses
DPULE	GO:0017153	sodium:dicarboxylate symporter activity	Losses
DPULE	GO:0015075	ion transmembrane transporter activity	Losses
DPULE	GO:0015085	calcium ion transmembrane transporter activity	Losses
DPULE	GO:0008092	cytoskeletal protein binding	Losses
DPULE	GO:0004872	receptor activity	Losses
DPULE	GO:0038023	signaling receptor activity	Losses
DPULE	GO:0016788	hydrolase activity, acting on ester bonds	Losses
DPULE	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
DPULE	GO:0015269	calcium-activated potassium channel activity	Losses
DPULE	GO:0019894	kinesin binding	Losses
DPULE	GO:0005262	calcium channel activity	Losses
DPULE	GO:0042578	phosphoric ester hydrolase activity	Losses
DPULE	GO:0008188	neuropeptide receptor activity	Losses
DPULE	GO:0005509	calcium ion binding	Losses
DPULE	GO:0005254	chloride channel activity	Losses
DPULE	GO:0019901	protein kinase binding	Losses
DPULE	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
DPULE	GO:0005253	anion channel activity	Losses
DPULE	GO:0009008	DNA-methyltransferase activity	Losses
DPULE	GO:0015291	secondary active transmembrane transporter activity	Losses
DPULE	GO:0005057	signal transducer activity, downstream of receptor	Losses
DPULE	GO:0005244	voltage-gated ion channel activity	Losses
DPULE	GO:0022832	voltage-gated channel activity	Losses
DPULE	GO:0015081	sodium ion transmembrane transporter activity	Losses
DPULE	GO:0015108	chloride transmembrane transporter activity	Losses
DPULE	GO:0060090	molecular adaptor activity	Losses
DPULE	GO:0008528	G-protein coupled peptide receptor activity	Losses
DPULE	GO:0015103	inorganic anion transmembrane transporter activity	Losses
DPULE	GO:0005215	transporter activity	Losses
DPULE	GO:0001653	peptide receptor activity	Losses
DPULE	GO:0030594	neurotransmitter receptor activity	Losses
DPULE	GO:0004713	protein tyrosine kinase activity	Losses
DPULE	GO:0022843	voltage-gated cation channel activity	Losses
DPULE	GO:0050254	rhodopsin kinase activity	Losses
DPULE	GO:0003824	catalytic activity	Losses
DPULE	GO:0004983	neuropeptide Y receptor activity	Losses
DPULE	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Losses
DPULE	GO:0004672	protein kinase activity	Losses
DPULE	GO:0000166	nucleotide binding	Losses
DPULE	GO:1901265	nucleoside phosphate binding	Losses
DPULE	GO:0004536	deoxyribonuclease activity	Losses
DPULE	GO:0015293	symporter activity	Losses
DPULE	GO:0022824	transmitter-gated ion channel activity	Losses
DPULE	GO:0022835	transmitter-gated channel activity	Losses
DPULE	GO:0004970	ionotropic glutamate receptor activity	Losses
DPULE	GO:0004707	MAP kinase activity	Losses
DPULE	GO:0008172	S-methyltransferase activity	Losses
DPULE	GO:0005343	organic acid:sodium symporter activity	Losses
DPULE	GO:0015370	solute:sodium symporter activity	Losses
DPULE	GO:0016787	hydrolase activity	Losses
DPULE	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
DPULE	GO:0019900	kinase binding	Losses
DPULE	GO:0005249	voltage-gated potassium channel activity	Losses
DPULE	GO:0004520	endodeoxyribonuclease activity	Losses
DPULE	GO:0005524	ATP binding	Losses
DPULE	GO:0032559	adenyl ribonucleotide binding	Losses
DPULE	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
DPULE	GO:0035591	signaling adaptor activity	Losses
DPULE	GO:0004385	guanylate kinase activity	Losses
DPULE	GO:1901682	sulfur compound transmembrane transporter activity	Losses
DPULE	GO:0070888	E-box binding	Losses
DPULE	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
DPULE	GO:0005225	volume-sensitive anion channel activity	Losses
DPULE	GO:0005219	ryanodine-sensitive calcium-release channel activity	Losses
DPULE	GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Losses
DPULE	GO:0070513	death domain binding	Losses
DPULE	GO:0015499	formate transmembrane transporter activity	Losses
DPULE	GO:0016990	arginine deiminase activity	Losses
DPULE	GO:0043914	NADPH:sulfur oxidoreductase activity	Losses
DPULE	GO:0004824	lysine-tRNA ligase activity	Losses
DPULE	GO:0004802	transketolase activity	Losses
DPULE	GO:0004807	triose-phosphate isomerase activity	Losses
DPULE	GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Losses
DPULE	GO:0001784	phosphotyrosine residue binding	Losses
DPULE	GO:0015106	bicarbonate transmembrane transporter activity	Losses
DPULE	GO:0050093	methanol dehydrogenase activity	Losses
DPULE	GO:0015250	water channel activity	Losses
DPULE	GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	Losses
DPULE	GO:0003941	L-serine ammonia-lyase activity	Losses
DPULE	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
DPULE	GO:0015277	kainate selective glutamate receptor activity	Losses
DPULE	GO:0032028	myosin head/neck binding	Losses
DPULE	GO:0018834	dichloromethane dehalogenase activity	Losses
DPULE	GO:0031489	myosin V binding	Losses
DPULE	GO:0106017	phosphatidylinositol-3,4-bisphosphate phosphatase activity	Losses
DPULE	GO:0016312	inositol bisphosphate phosphatase activity	Losses
DPULE	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	Losses
DPULE	GO:0047150	betaine-homocysteine S-methyltransferase activity	Losses
DPULE	GO:0018580	nitronate monooxygenase activity	Losses
DPULE	GO:0017020	myosin phosphatase regulator activity	Losses
DPULE	GO:0070984	SET domain binding	Losses
DPULE	GO:0046570	methylthioribulose 1-phosphate dehydratase activity	Losses
DPULE	GO:0019531	oxalate transmembrane transporter activity	Losses
DPULE	GO:0016403	dimethylargininase activity	Losses
DPULE	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
DPULE	GO:0036401	pyrokinin receptor activity	Losses
DPULE	GO:0005026	transforming growth factor beta receptor activity, type II	Losses
DPULE	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	Losses
DPULE	GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	Losses
DPULE	GO:0005003	ephrin receptor activity	Losses
DPULE	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Losses
DPULE	GO:0045309	protein phosphorylated amino acid binding	Losses
DPULE	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	Losses
DPULE	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Losses
DPULE	GO:0005368	taurine transmembrane transporter activity	Losses
DPULE	GO:0005369	taurine:sodium symporter activity	Losses
DPULE	GO:0005372	water transmembrane transporter activity	Losses
DPULE	GO:0047623	adenosine-phosphate deaminase activity	Losses
DPULE	GO:0004490	methylglutaconyl-CoA hydratase activity	Losses
DPULE	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
DPULE	GO:0004423	iduronate-2-sulfatase activity	Losses
DPULE	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	Losses
DPULE	GO:0003876	AMP deaminase activity	Losses
DPULE	GO:0004157	dihydropyrimidinase activity	Losses
DPULE	GO:0072320	volume-sensitive chloride channel activity	Losses
DPULE	GO:0004133	glycogen debranching enzyme activity	Losses
DPULE	GO:0004134	4-alpha-glucanotransferase activity	Losses
DPULE	GO:0004135	amylo-alpha-1,6-glucosidase activity	Losses
DPULE	GO:0070735	protein-glycine ligase activity	Losses
DPULE	GO:0070736	protein-glycine ligase activity, initiating	Losses
DPULE	GO:0070737	protein-glycine ligase activity, elongating	Losses
DPULE	GO:0047061	glucose-fructose oxidoreductase activity	Losses
DPULE	GO:0070854	myosin VI heavy chain binding	Losses
DPULE	GO:0070855	myosin VI head/neck binding	Losses
DPULE	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
DPULE	GO:0008066	glutamate receptor activity	Losses
DPULE	GO:0030554	adenyl nucleotide binding	Losses
DPULE	GO:0016791	phosphatase activity	Extinctions
DPULE	GO:0004721	phosphoprotein phosphatase activity	Extinctions
DPULE	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
DPULE	GO:0042578	phosphoric ester hydrolase activity	Extinctions
DPULE	GO:0005057	signal transducer activity, downstream of receptor	Extinctions
DPULE	GO:0140096	catalytic activity, acting on a protein	Extinctions
DPULE	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
DPULE	GO:0004536	deoxyribonuclease activity	Extinctions
DPULE	GO:0004520	endodeoxyribonuclease activity	Extinctions
DPULE	GO:0004707	MAP kinase activity	Extinctions
DPULE	GO:0008172	S-methyltransferase activity	Extinctions
DPULE	GO:0003824	catalytic activity	Extinctions
DPULE	GO:0016787	hydrolase activity	Extinctions
DPULE	GO:0008484	sulfuric ester hydrolase activity	Extinctions
DPULE	GO:0004620	phospholipase activity	Extinctions
DPULE	GO:0052745	inositol phosphate phosphatase activity	Extinctions
DPULE	GO:0004622	lysophospholipase activity	Extinctions
DPULE	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
DPULE	GO:0070888	E-box binding	Extinctions
DPULE	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Extinctions
DPULE	GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Extinctions
DPULE	GO:0070513	death domain binding	Extinctions
DPULE	GO:0016990	arginine deiminase activity	Extinctions
DPULE	GO:0043914	NADPH:sulfur oxidoreductase activity	Extinctions
DPULE	GO:0004824	lysine-tRNA ligase activity	Extinctions
DPULE	GO:0004807	triose-phosphate isomerase activity	Extinctions
DPULE	GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Extinctions
DPULE	GO:0001784	phosphotyrosine residue binding	Extinctions
DPULE	GO:0050093	methanol dehydrogenase activity	Extinctions
DPULE	GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	Extinctions
DPULE	GO:0003941	L-serine ammonia-lyase activity	Extinctions
DPULE	GO:0018834	dichloromethane dehalogenase activity	Extinctions
DPULE	GO:0016312	inositol bisphosphate phosphatase activity	Extinctions
DPULE	GO:0047150	betaine-homocysteine S-methyltransferase activity	Extinctions
DPULE	GO:0018580	nitronate monooxygenase activity	Extinctions
DPULE	GO:0017020	myosin phosphatase regulator activity	Extinctions
DPULE	GO:0070984	SET domain binding	Extinctions
DPULE	GO:0046570	methylthioribulose 1-phosphate dehydratase activity	Extinctions
DPULE	GO:0016403	dimethylargininase activity	Extinctions
DPULE	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Extinctions
DPULE	GO:0036401	pyrokinin receptor activity	Extinctions
DPULE	GO:0005026	transforming growth factor beta receptor activity, type II	Extinctions
DPULE	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
DPULE	GO:0045309	protein phosphorylated amino acid binding	Extinctions
DPULE	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Extinctions
DPULE	GO:0005368	taurine transmembrane transporter activity	Extinctions
DPULE	GO:0005369	taurine:sodium symporter activity	Extinctions
DPULE	GO:0047623	adenosine-phosphate deaminase activity	Extinctions
DPULE	GO:0004423	iduronate-2-sulfatase activity	Extinctions
DPULE	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	Extinctions
DPULE	GO:0003876	AMP deaminase activity	Extinctions
DPULE	GO:0004133	glycogen debranching enzyme activity	Extinctions
DPULE	GO:0004134	4-alpha-glucanotransferase activity	Extinctions
DPULE	GO:0004135	amylo-alpha-1,6-glucosidase activity	Extinctions
DPULE	GO:0070735	protein-glycine ligase activity	Extinctions
DPULE	GO:0070736	protein-glycine ligase activity, initiating	Extinctions
DPULE	GO:0070737	protein-glycine ligase activity, elongating	Extinctions
DPULE	GO:0047061	glucose-fructose oxidoreductase activity	Extinctions
DPULE	GO:0030674	protein binding, bridging	Extinctions
DPULE	GO:0004842	ubiquitin-protein transferase activity	Extinctions
DPULE	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
DPULE	GO:0005509	calcium ion binding	Extinctions
FOCCI	GO:0016829	lyase activity	Gains
FOCCI	GO:0005215	transporter activity	Gains
FOCCI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
FOCCI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
FOCCI	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
FOCCI	GO:0005549	odorant binding	Gains
FOCCI	GO:0038023	signaling receptor activity	Gains
FOCCI	GO:0048037	cofactor binding	Gains
FOCCI	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
FOCCI	GO:0004673	protein histidine kinase activity	Gains
FOCCI	GO:0000155	phosphorelay sensor kinase activity	Gains
FOCCI	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
FOCCI	GO:0004872	receptor activity	Gains
FOCCI	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Gains
FOCCI	GO:0019842	vitamin binding	Gains
FOCCI	GO:0140097	catalytic activity, acting on DNA	Gains
FOCCI	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
FOCCI	GO:0004888	transmembrane signaling receptor activity	Gains
FOCCI	GO:0042834	peptidoglycan binding	Gains
FOCCI	GO:0000156	phosphorelay response regulator activity	Gains
FOCCI	GO:0016491	oxidoreductase activity	Gains
FOCCI	GO:0015294	solute:cation symporter activity	Gains
FOCCI	GO:0099600	transmembrane receptor activity	Gains
FOCCI	GO:0004871	signal transducer activity	Gains
FOCCI	GO:0015293	symporter activity	Gains
FOCCI	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
FOCCI	GO:0016835	carbon-oxygen lyase activity	Gains
FOCCI	GO:0038187	pattern recognition receptor activity	Gains
FOCCI	GO:0008658	penicillin binding	Gains
FOCCI	GO:0001530	lipopolysaccharide binding	Gains
FOCCI	GO:0016841	ammonia-lyase activity	Gains
FOCCI	GO:0008329	signaling pattern recognition receptor activity	Gains
FOCCI	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
FOCCI	GO:0003823	antigen binding	Gains
FOCCI	GO:0060089	molecular transducer activity	Gains
FOCCI	GO:0017153	sodium:dicarboxylate symporter activity	Gains
FOCCI	GO:0008158	hedgehog receptor activity	Gains
FOCCI	GO:0030170	pyridoxal phosphate binding	Gains
FOCCI	GO:0070279	vitamin B6 binding	Gains
FOCCI	GO:0003993	acid phosphatase activity	Gains
FOCCI	GO:0008061	chitin binding	Gains
FOCCI	GO:0043022	ribosome binding	Gains
FOCCI	GO:0050662	coenzyme binding	Gains
FOCCI	GO:0004866	endopeptidase inhibitor activity	Gains
FOCCI	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Gains
FOCCI	GO:0004503	monophenol monooxygenase activity	Gains
FOCCI	GO:0008681	2-octaprenyl-6-methoxyphenol hydroxylase activity	Gains
FOCCI	GO:0043874	acireductone synthase activity	Gains
FOCCI	GO:0001872	(1->3)-beta-D-glucan binding	Gains
FOCCI	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
FOCCI	GO:0035586	purinergic receptor activity	Gains
FOCCI	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	Gains
FOCCI	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	Gains
FOCCI	GO:0004984	olfactory receptor activity	Gains
FOCCI	GO:1901681	sulfur compound binding	Gains
FOCCI	GO:0015291	secondary active transmembrane transporter activity	Gains
FOCCI	GO:0030165	PDZ domain binding	Gains
FOCCI	GO:0030976	thiamine pyrophosphate binding	Gains
FOCCI	GO:0005351	sugar:proton symporter activity	Gains
FOCCI	GO:0005402	cation:sugar symporter activity	Gains
FOCCI	GO:0015295	solute:proton symporter activity	Gains
FOCCI	GO:0051920	peroxiredoxin activity	Gains
FOCCI	GO:0033293	monocarboxylic acid binding	Gains
FOCCI	GO:0031406	carboxylic acid binding	Gains
FOCCI	GO:0043177	organic acid binding	Gains
FOCCI	GO:0015296	anion:cation symporter activity	Gains
FOCCI	GO:0004930	G-protein coupled receptor activity	Gains
FOCCI	GO:0003678	DNA helicase activity	Gains
FOCCI	GO:0004252	serine-type endopeptidase activity	Gains
FOCCI	GO:0061135	endopeptidase regulator activity	Gains
FOCCI	GO:0004857	enzyme inhibitor activity	Gains
FOCCI	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Gains
FOCCI	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Gains
FOCCI	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
FOCCI	GO:0005539	glycosaminoglycan binding	Gains
FOCCI	GO:0003700	DNA binding transcription factor activity	Losses
FOCCI	GO:0140110	transcription regulator activity	Losses
FOCCI	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
FOCCI	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
FOCCI	GO:0046914	transition metal ion binding	Losses
FOCCI	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
FOCCI	GO:0004497	monooxygenase activity	Losses
FOCCI	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Losses
FOCCI	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
FOCCI	GO:0030545	receptor regulator activity	Losses
FOCCI	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
FOCCI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
FOCCI	GO:0070330	aromatase activity	Losses
FOCCI	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
FOCCI	GO:0019992	diacylglycerol binding	Losses
FOCCI	GO:0043565	sequence-specific DNA binding	Losses
FOCCI	GO:0004871	signal transducer activity	Losses
FOCCI	GO:0005179	hormone activity	Losses
FOCCI	GO:0008270	zinc ion binding	Losses
FOCCI	GO:0048018	receptor ligand activity	Losses
FOCCI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
FOCCI	GO:0060089	molecular transducer activity	Losses
FOCCI	GO:0099600	transmembrane receptor activity	Losses
FOCCI	GO:0004872	receptor activity	Losses
FOCCI	GO:0005506	iron ion binding	Losses
FOCCI	GO:0008509	anion transmembrane transporter activity	Losses
FOCCI	GO:0004930	G-protein coupled receptor activity	Losses
FOCCI	GO:0038023	signaling receptor activity	Losses
FOCCI	GO:0046906	tetrapyrrole binding	Losses
FOCCI	GO:0003677	DNA binding	Losses
FOCCI	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	Losses
FOCCI	GO:0098772	molecular function regulator	Losses
FOCCI	GO:0030291	protein serine/threonine kinase inhibitor activity	Losses
FOCCI	GO:0004344	glucose dehydrogenase activity	Losses
FOCCI	GO:0008812	choline dehydrogenase activity	Losses
FOCCI	GO:0004888	transmembrane signaling receptor activity	Losses
FOCCI	GO:0005184	neuropeptide hormone activity	Losses
FOCCI	GO:0008514	organic anion transmembrane transporter activity	Losses
FOCCI	GO:0005201	extracellular matrix structural constituent	Losses
FOCCI	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
FOCCI	GO:0004983	neuropeptide Y receptor activity	Losses
FOCCI	GO:0004860	protein kinase inhibitor activity	Losses
FOCCI	GO:0004993	G-protein coupled serotonin receptor activity	Losses
FOCCI	GO:0031208	POZ domain binding	Losses
FOCCI	GO:0099589	serotonin receptor activity	Losses
FOCCI	GO:0032450	maltose alpha-glucosidase activity	Losses
FOCCI	GO:0019210	kinase inhibitor activity	Losses
FOCCI	GO:0043169	cation binding	Losses
FOCCI	GO:0044212	transcription regulatory region DNA binding	Losses
FOCCI	GO:0000975	regulatory region DNA binding	Losses
FOCCI	GO:0001067	regulatory region nucleic acid binding	Losses
FOCCI	GO:0046982	protein heterodimerization activity	Losses
FOCCI	GO:0046872	metal ion binding	Losses
FOCCI	GO:0005230	extracellular ligand-gated ion channel activity	Losses
FOCCI	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Extinctions
FOCCI	GO:0003700	DNA binding transcription factor activity	Extinctions
FOCCI	GO:0030545	receptor regulator activity	Extinctions
FOCCI	GO:0098772	molecular function regulator	Extinctions
FOCCI	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	Extinctions
FOCCI	GO:0140110	transcription regulator activity	Extinctions
FOCCI	GO:0005184	neuropeptide hormone activity	Extinctions
FOCCI	GO:0030291	protein serine/threonine kinase inhibitor activity	Extinctions
FOCCI	GO:0004983	neuropeptide Y receptor activity	Extinctions
FOCCI	GO:0046943	carboxylic acid transmembrane transporter activity	Extinctions
FOCCI	GO:0005342	organic acid transmembrane transporter activity	Extinctions
FOCCI	GO:0004857	enzyme inhibitor activity	Extinctions
FOCCI	GO:0046914	transition metal ion binding	Extinctions
FOCCI	GO:0048018	receptor ligand activity	Extinctions
FOCCI	GO:0004860	protein kinase inhibitor activity	Extinctions
FOCCI	GO:0019210	kinase inhibitor activity	Extinctions
FOCCI	GO:0008301	DNA binding, bending	Extinctions
FOCCI	GO:0008028	monocarboxylic acid transmembrane transporter activity	Extinctions
FOCCI	GO:0008430	selenium binding	Extinctions
FOCCI	GO:0005179	hormone activity	Extinctions
FOCCI	GO:0004930	G-protein coupled receptor activity	Extinctions
FOCCI	GO:0008066	glutamate receptor activity	Extinctions
FOCCI	GO:0008194	UDP-glycosyltransferase activity	Extinctions
FOCCI	GO:0008514	organic anion transmembrane transporter activity	Extinctions
FOCCI	GO:0008188	neuropeptide receptor activity	Extinctions
FOCCI	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Extinctions
FOCCI	GO:0008805	carbon-monoxide oxygenase activity	Extinctions
FOCCI	GO:0019784	NEDD8-specific protease activity	Extinctions
FOCCI	GO:0035368	selenocysteine insertion sequence binding	Extinctions
FOCCI	GO:0001587	Gq/11-coupled serotonin receptor activity	Extinctions
FOCCI	GO:0035236	proctolin receptor activity	Extinctions
FOCCI	GO:0008936	nicotinamidase activity	Extinctions
FOCCI	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Extinctions
FOCCI	GO:0017128	phospholipid scramblase activity	Extinctions
FOCCI	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Extinctions
FOCCI	GO:0004157	dihydropyrimidinase activity	Extinctions
FOCCI	GO:0008798	beta-aspartyl-peptidase activity	Extinctions
FOCCI	GO:0000257	nitrilase activity	Extinctions
FOCCI	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
FOCCI	GO:0008781	N-acylneuraminate cytidylyltransferase activity	Extinctions
2	GO:0005230	extracellular ligand-gated ion channel activity	Gains
2	GO:0008066	glutamate receptor activity	Gains
2	GO:0015276	ligand-gated ion channel activity	Gains
2	GO:0022834	ligand-gated channel activity	Gains
2	GO:0003964	RNA-directed DNA polymerase activity	Gains
2	GO:0022824	transmitter-gated ion channel activity	Gains
2	GO:0022835	transmitter-gated channel activity	Gains
2	GO:0004970	ionotropic glutamate receptor activity	Gains
2	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
2	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
2	GO:0099600	transmembrane receptor activity	Gains
2	GO:0030594	neurotransmitter receptor activity	Gains
2	GO:0022857	transmembrane transporter activity	Gains
2	GO:0008378	galactosyltransferase activity	Gains
2	GO:0022891	substrate-specific transmembrane transporter activity	Gains
2	GO:0005549	odorant binding	Gains
2	GO:0015075	ion transmembrane transporter activity	Gains
2	GO:0022836	gated channel activity	Gains
2	GO:0004888	transmembrane signaling receptor activity	Gains
2	GO:0034061	DNA polymerase activity	Gains
2	GO:0005215	transporter activity	Gains
2	GO:0140097	catalytic activity, acting on DNA	Gains
2	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
2	GO:0022892	substrate-specific transporter activity	Gains
2	GO:0008061	chitin binding	Gains
2	GO:0005216	ion channel activity	Gains
2	GO:0022838	substrate-specific channel activity	Gains
2	GO:0035250	UDP-galactosyltransferase activity	Gains
2	GO:0038023	signaling receptor activity	Gains
2	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
2	GO:0015267	channel activity	Gains
2	GO:0022803	passive transmembrane transporter activity	Gains
2	GO:0004872	receptor activity	Gains
2	GO:0008812	choline dehydrogenase activity	Gains
2	GO:0004984	olfactory receptor activity	Gains
2	GO:0060089	molecular transducer activity	Gains
2	GO:0017153	sodium:dicarboxylate symporter activity	Gains
2	GO:0008556	potassium-transporting ATPase activity	Gains
2	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
2	GO:0004871	signal transducer activity	Gains
2	GO:0008527	taste receptor activity	Gains
2	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
2	GO:0004930	G-protein coupled receptor activity	Gains
2	GO:0016779	nucleotidyltransferase activity	Gains
2	GO:0004568	chitinase activity	Gains
2	GO:0042302	structural constituent of cuticle	Gains
2	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	Gains
2	GO:0003700	DNA binding transcription factor activity	Losses
2	GO:0044212	transcription regulatory region DNA binding	Losses
2	GO:0001067	regulatory region nucleic acid binding	Losses
2	GO:0000975	regulatory region DNA binding	Losses
2	GO:0140110	transcription regulator activity	Losses
2	GO:0043565	sequence-specific DNA binding	Losses
2	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
2	GO:1990837	sequence-specific double-stranded DNA binding	Losses
2	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
2	GO:0003690	double-stranded DNA binding	Losses
2	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
2	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
2	GO:0004930	G-protein coupled receptor activity	Losses
2	GO:0003677	DNA binding	Losses
2	GO:1990939	ATP-dependent microtubule motor activity	Losses
2	GO:0004000	adenosine deaminase activity	Losses
2	GO:0003964	RNA-directed DNA polymerase activity	Losses
2	GO:0004872	receptor activity	Losses
2	GO:0008188	neuropeptide receptor activity	Losses
2	GO:0004667	prostaglandin-D synthase activity	Losses
2	GO:0004097	catechol oxidase activity	Losses
2	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
2	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
2	GO:0036263	L-DOPA monooxygenase activity	Losses
2	GO:0036264	dopamine monooxygenase activity	Losses
2	GO:0005436	sodium:phosphate symporter activity	Losses
2	GO:0038023	signaling receptor activity	Losses
2	GO:0070001	aspartic-type peptidase activity	Losses
2	GO:0004190	aspartic-type endopeptidase activity	Losses
2	GO:0008528	G-protein coupled peptide receptor activity	Losses
2	GO:0060089	molecular transducer activity	Losses
2	GO:0001653	peptide receptor activity	Losses
2	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
2	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
2	GO:0004888	transmembrane signaling receptor activity	Losses
2	GO:0019239	deaminase activity	Losses
2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
2	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
2	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
2	GO:0008227	G-protein coupled amine receptor activity	Losses
2	GO:0003676	nucleic acid binding	Losses
2	GO:0004657	proline dehydrogenase activity	Losses
2	GO:0043425	bHLH transcription factor binding	Losses
2	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
2	GO:0004995	tachykinin receptor activity	Losses
2	GO:0004950	chemokine receptor activity	Losses
2	GO:0004972	NMDA glutamate receptor activity	Losses
2	GO:0016286	small conductance calcium-activated potassium channel activity	Losses
2	GO:0008422	beta-glucosidase activity	Losses
2	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
2	GO:0005314	high-affinity glutamate transmembrane transporter activity	Losses
2	GO:0046423	allene-oxide cyclase activity	Losses
2	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Losses
2	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
2	GO:0005520	insulin-like growth factor binding	Losses
2	GO:0004503	monophenol monooxygenase activity	Losses
2	GO:0008061	chitin binding	Losses
2	GO:0099600	transmembrane receptor activity	Losses
2	GO:0034061	DNA polymerase activity	Losses
2	GO:0016849	phosphorus-oxygen lyase activity	Losses
2	GO:0009975	cyclase activity	Losses
2	GO:0019838	growth factor binding	Losses
2	GO:0009922	fatty acid elongase activity	Losses
2	GO:0004064	arylesterase activity	Losses
2	GO:0004348	glucosylceramidase activity	Losses
2	GO:0004896	cytokine receptor activity	Losses
2	GO:0052689	carboxylic ester hydrolase activity	Losses
2	GO:0004252	serine-type endopeptidase activity	Novel expansions
2	GO:0008236	serine-type peptidase activity	Novel expansions
2	GO:0017171	serine hydrolase activity	Novel expansions
2	GO:0004175	endopeptidase activity	Novel expansions
2	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
2	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
2	GO:0044212	transcription regulatory region DNA binding	Extinctions
2	GO:0001067	regulatory region nucleic acid binding	Extinctions
2	GO:0000975	regulatory region DNA binding	Extinctions
2	GO:0003690	double-stranded DNA binding	Extinctions
2	GO:0001012	RNA polymerase II regulatory region DNA binding	Extinctions
2	GO:0140110	transcription regulator activity	Extinctions
2	GO:0004000	adenosine deaminase activity	Extinctions
2	GO:1990939	ATP-dependent microtubule motor activity	Extinctions
2	GO:0003700	DNA binding transcription factor activity	Extinctions
2	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Extinctions
2	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
2	GO:0019239	deaminase activity	Extinctions
2	GO:0043565	sequence-specific DNA binding	Extinctions
2	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Extinctions
2	GO:0004657	proline dehydrogenase activity	Extinctions
2	GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
2	GO:0008422	beta-glucosidase activity	Extinctions
2	GO:0005520	insulin-like growth factor binding	Extinctions
2	GO:0019838	growth factor binding	Extinctions
2	GO:0004064	arylesterase activity	Extinctions
2	GO:0004348	glucosylceramidase activity	Extinctions
2	GO:0001965	G-protein alpha-subunit binding	Extinctions
2	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Extinctions
2	GO:0004784	superoxide dismutase activity	Extinctions
2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Extinctions
2	GO:0004736	pyruvate carboxylase activity	Extinctions
2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Extinctions
2	GO:0019205	nucleobase-containing compound kinase activity	Extinctions
2	GO:0004930	G-protein coupled receptor activity	Extinctions
2	GO:0005267	potassium channel activity	Extinctions
2	GO:0015269	calcium-activated potassium channel activity	Extinctions
2	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Extinctions
GMORS	GO:0034062	5'-3' RNA polymerase activity	Gains
GMORS	GO:0097747	RNA polymerase activity	Gains
GMORS	GO:0004252	serine-type endopeptidase activity	Gains
GMORS	GO:0008236	serine-type peptidase activity	Gains
GMORS	GO:0017171	serine hydrolase activity	Gains
GMORS	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
GMORS	GO:0008233	peptidase activity	Gains
GMORS	GO:0004386	helicase activity	Gains
GMORS	GO:0030145	manganese ion binding	Gains
GMORS	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Gains
GMORS	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Gains
GMORS	GO:0001103	RNA polymerase II repressing transcription factor binding	Gains
GMORS	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
GMORS	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
GMORS	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
GMORS	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
GMORS	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Gains
GMORS	GO:0016418	S-acetyltransferase activity	Gains
GMORS	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GMORS	GO:0016887	ATPase activity	Gains
GMORS	GO:0017111	nucleoside-triphosphatase activity	Gains
GMORS	GO:0003678	DNA helicase activity	Gains
GMORS	GO:0016787	hydrolase activity	Gains
GMORS	GO:0003777	microtubule motor activity	Gains
GMORS	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
GMORS	GO:0036002	pre-mRNA binding	Gains
GMORS	GO:0030215	semaphorin receptor binding	Gains
GMORS	GO:0008026	ATP-dependent helicase activity	Gains
GMORS	GO:0070035	purine NTP-dependent helicase activity	Gains
GMORS	GO:0016462	pyrophosphatase activity	Gains
GMORS	GO:0004003	ATP-dependent DNA helicase activity	Gains
GMORS	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
GMORS	GO:0004175	endopeptidase activity	Gains
GMORS	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
GMORS	GO:0008296	3'-5'-exodeoxyribonuclease activity	Gains
GMORS	GO:0016874	ligase activity	Gains
GMORS	GO:0003676	nucleic acid binding	Gains
GMORS	GO:0008061	chitin binding	Losses
GMORS	GO:0008527	taste receptor activity	Losses
GMORS	GO:0008376	acetylgalactosaminyltransferase activity	Losses
GMORS	GO:0003964	RNA-directed DNA polymerase activity	Losses
GMORS	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Losses
GMORS	GO:0042302	structural constituent of cuticle	Losses
GMORS	GO:0005214	structural constituent of chitin-based cuticle	Losses
GMORS	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GMORS	GO:0005044	scavenger receptor activity	Losses
GMORS	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
GMORS	GO:0008066	glutamate receptor activity	Losses
GMORS	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Losses
GMORS	GO:0022824	transmitter-gated ion channel activity	Losses
GMORS	GO:0022835	transmitter-gated channel activity	Losses
GMORS	GO:0004970	ionotropic glutamate receptor activity	Losses
GMORS	GO:0005272	sodium channel activity	Losses
GMORS	GO:0005549	odorant binding	Losses
GMORS	GO:0016859	cis-trans isomerase activity	Losses
GMORS	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GMORS	GO:0038024	cargo receptor activity	Losses
GMORS	GO:0005230	extracellular ligand-gated ion channel activity	Losses
GMORS	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GMORS	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GMORS	GO:0022857	transmembrane transporter activity	Losses
GMORS	GO:0004872	receptor activity	Losses
GMORS	GO:0060089	molecular transducer activity	Losses
GMORS	GO:0005215	transporter activity	Losses
GMORS	GO:0030594	neurotransmitter receptor activity	Losses
GMORS	GO:0070001	aspartic-type peptidase activity	Losses
GMORS	GO:0004190	aspartic-type endopeptidase activity	Losses
GMORS	GO:0015075	ion transmembrane transporter activity	Losses
GMORS	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GMORS	GO:1901682	sulfur compound transmembrane transporter activity	Losses
GMORS	GO:0022834	ligand-gated channel activity	Losses
GMORS	GO:0015276	ligand-gated ion channel activity	Losses
GMORS	GO:0046914	transition metal ion binding	Losses
GMORS	GO:0008233	peptidase activity	Losses
GMORS	GO:0004984	olfactory receptor activity	Losses
GMORS	GO:0034061	DNA polymerase activity	Losses
GMORS	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
GMORS	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Losses
GMORS	GO:0038023	signaling receptor activity	Losses
GMORS	GO:0005216	ion channel activity	Losses
GMORS	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
GMORS	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
GMORS	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Losses
GMORS	GO:0016848	carbon-halide lyase activity	Losses
GMORS	GO:0015054	gastrin receptor activity	Losses
GMORS	GO:0004046	aminoacylase activity	Losses
GMORS	GO:0004335	galactokinase activity	Losses
GMORS	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
GMORS	GO:0033041	sweet taste receptor activity	Losses
GMORS	GO:0022838	substrate-specific channel activity	Losses
GMORS	GO:0005506	iron ion binding	Losses
GMORS	GO:0004180	carboxypeptidase activity	Losses
GMORS	GO:0099600	transmembrane receptor activity	Losses
GMORS	GO:0022803	passive transmembrane transporter activity	Losses
GMORS	GO:0015267	channel activity	Losses
GMORS	GO:0016408	C-acyltransferase activity	Losses
GMORS	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
GMORS	GO:0019200	carbohydrate kinase activity	Losses
GMORS	GO:0008194	UDP-glycosyltransferase activity	Losses
GMORS	GO:0016491	oxidoreductase activity	Losses
GMORS	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GMORS	GO:0005198	structural molecule activity	Losses
GMORS	GO:0004175	endopeptidase activity	Losses
GMORS	GO:0022891	substrate-specific transmembrane transporter activity	Losses
GMORS	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
GMORS	GO:0004888	transmembrane signaling receptor activity	Losses
GMORS	GO:0022836	gated channel activity	Losses
GMORS	GO:0030246	carbohydrate binding	Losses
GMORS	GO:0008324	cation transmembrane transporter activity	Losses
GMORS	GO:0003735	structural constituent of ribosome	Losses
GMORS	GO:0000295	adenine nucleotide transmembrane transporter activity	Losses
GMORS	GO:0004630	phospholipase D activity	Losses
GMORS	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Losses
GMORS	GO:0004040	amidase activity	Losses
GMORS	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Losses
GMORS	GO:0005346	purine ribonucleotide transmembrane transporter activity	Losses
GMORS	GO:0015116	sulfate transmembrane transporter activity	Losses
GMORS	GO:0015277	kainate selective glutamate receptor activity	Losses
GMORS	GO:0015215	nucleotide transmembrane transporter activity	Losses
GMORS	GO:0015216	purine nucleotide transmembrane transporter activity	Losses
GMORS	GO:0017171	serine hydrolase activity	Losses
GMORS	GO:0009055	electron transfer activity	Losses
GMORS	GO:0015081	sodium ion transmembrane transporter activity	Losses
GMORS	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Losses
GMORS	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
GMORS	GO:0048029	monosaccharide binding	Losses
GMORS	GO:0008234	cysteine-type peptidase activity	Losses
GMORS	GO:0016853	isomerase activity	Losses
GMORS	GO:0016209	antioxidant activity	Losses
GMORS	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GMORS	GO:0008061	chitin binding	Extinctions
GMORS	GO:0008527	taste receptor activity	Extinctions
GMORS	GO:0003735	structural constituent of ribosome	Extinctions
GMORS	GO:0008376	acetylgalactosaminyltransferase activity	Extinctions
GMORS	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
GMORS	GO:0005044	scavenger receptor activity	Extinctions
GMORS	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
GMORS	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Extinctions
GMORS	GO:0015054	gastrin receptor activity	Extinctions
GMORS	GO:0004335	galactokinase activity	Extinctions
GMORS	GO:0033041	sweet taste receptor activity	Extinctions
GMORS	GO:0016859	cis-trans isomerase activity	Extinctions
GMORS	GO:0038024	cargo receptor activity	Extinctions
GMORS	GO:0008066	glutamate receptor activity	Extinctions
GMORS	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Extinctions
GMORS	GO:0000295	adenine nucleotide transmembrane transporter activity	Extinctions
GMORS	GO:0004630	phospholipase D activity	Extinctions
GMORS	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Extinctions
GMORS	GO:0005346	purine ribonucleotide transmembrane transporter activity	Extinctions
GMORS	GO:0015215	nucleotide transmembrane transporter activity	Extinctions
GMORS	GO:0015216	purine nucleotide transmembrane transporter activity	Extinctions
GMORS	GO:1901682	sulfur compound transmembrane transporter activity	Extinctions
GMORS	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
GMORS	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
GMORS	GO:0022824	transmitter-gated ion channel activity	Extinctions
GMORS	GO:0022835	transmitter-gated channel activity	Extinctions
GMORS	GO:0004970	ionotropic glutamate receptor activity	Extinctions
GMORS	GO:0008234	cysteine-type peptidase activity	Extinctions
GMORS	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
GMORS	GO:0030594	neurotransmitter receptor activity	Extinctions
GMORS	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
GMORS	GO:0031418	L-ascorbic acid binding	Extinctions
GMORS	GO:0019200	carbohydrate kinase activity	Extinctions
GMORS	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AGLAB	GO:0003964	RNA-directed DNA polymerase activity	Gains
AGLAB	GO:0034061	DNA polymerase activity	Gains
AGLAB	GO:0140097	catalytic activity, acting on DNA	Gains
AGLAB	GO:0016779	nucleotidyltransferase activity	Gains
AGLAB	GO:0003676	nucleic acid binding	Gains
AGLAB	GO:0070001	aspartic-type peptidase activity	Gains
AGLAB	GO:0004190	aspartic-type endopeptidase activity	Gains
AGLAB	GO:0003677	DNA binding	Gains
AGLAB	GO:0005549	odorant binding	Gains
AGLAB	GO:0004984	olfactory receptor activity	Gains
AGLAB	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
AGLAB	GO:0004803	transposase activity	Gains
AGLAB	GO:0038023	signaling receptor activity	Gains
AGLAB	GO:0004888	transmembrane signaling receptor activity	Gains
AGLAB	GO:0099600	transmembrane receptor activity	Gains
AGLAB	GO:0008270	zinc ion binding	Gains
AGLAB	GO:0097159	organic cyclic compound binding	Gains
AGLAB	GO:0034062	5'-3' RNA polymerase activity	Gains
AGLAB	GO:0097747	RNA polymerase activity	Gains
AGLAB	GO:0004175	endopeptidase activity	Gains
AGLAB	GO:0008233	peptidase activity	Gains
AGLAB	GO:0004930	G-protein coupled receptor activity	Gains
AGLAB	GO:0004871	signal transducer activity	Gains
AGLAB	GO:1901363	heterocyclic compound binding	Gains
AGLAB	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
AGLAB	GO:0046914	transition metal ion binding	Gains
AGLAB	GO:0004872	receptor activity	Gains
AGLAB	GO:0060089	molecular transducer activity	Gains
AGLAB	GO:0004104	cholinesterase activity	Gains
AGLAB	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
AGLAB	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
AGLAB	GO:0005342	organic acid transmembrane transporter activity	Gains
AGLAB	GO:0004312	fatty acid synthase activity	Gains
AGLAB	GO:0004602	glutathione peroxidase activity	Gains
AGLAB	GO:0016802	trialkylsulfonium hydrolase activity	Gains
AGLAB	GO:0004013	adenosylhomocysteinase activity	Gains
AGLAB	GO:0005452	inorganic anion exchanger activity	Gains
AGLAB	GO:0008236	serine-type peptidase activity	Gains
AGLAB	GO:0015171	amino acid transmembrane transporter activity	Gains
AGLAB	GO:0004519	endonuclease activity	Gains
AGLAB	GO:0017171	serine hydrolase activity	Gains
AGLAB	GO:0015291	secondary active transmembrane transporter activity	Gains
AGLAB	GO:0004518	nuclease activity	Gains
AGLAB	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
AGLAB	GO:0004252	serine-type endopeptidase activity	Gains
AGLAB	GO:0003990	acetylcholinesterase activity	Gains
AGLAB	GO:0016801	hydrolase activity, acting on ether bonds	Gains
AGLAB	GO:0015501	glutamate:sodium symporter activity	Gains
AGLAB	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
AGLAB	GO:0050308	sugar-phosphatase activity	Gains
AGLAB	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
AGLAB	GO:0008449	N-acetylglucosamine-6-sulfatase activity	Gains
AGLAB	GO:0015183	L-aspartate transmembrane transporter activity	Gains
AGLAB	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Gains
AGLAB	GO:0008271	secondary active sulfate transmembrane transporter activity	Gains
AGLAB	GO:0016420	malonyltransferase activity	Gains
AGLAB	GO:0016419	S-malonyltransferase activity	Gains
AGLAB	GO:0005313	L-glutamate transmembrane transporter activity	Gains
AGLAB	GO:0015172	acidic amino acid transmembrane transporter activity	Gains
AGLAB	GO:0008514	organic anion transmembrane transporter activity	Gains
AGLAB	GO:0016408	C-acyltransferase activity	Gains
AGLAB	GO:0015296	anion:cation symporter activity	Gains
AGLAB	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
AGLAB	GO:0004879	nuclear receptor activity	Gains
AGLAB	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Gains
AGLAB	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
AGLAB	GO:0015179	L-amino acid transmembrane transporter activity	Gains
AGLAB	GO:0005057	signal transducer activity, downstream of receptor	Losses
AGLAB	GO:0004871	signal transducer activity	Losses
AGLAB	GO:0052689	carboxylic ester hydrolase activity	Losses
AGLAB	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Losses
AGLAB	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	Losses
AGLAB	GO:0016790	thiolester hydrolase activity	Losses
AGLAB	GO:0005254	chloride channel activity	Losses
AGLAB	GO:0004709	MAP kinase kinase kinase activity	Losses
AGLAB	GO:0005253	anion channel activity	Losses
AGLAB	GO:0015108	chloride transmembrane transporter activity	Losses
AGLAB	GO:0016298	lipase activity	Losses
AGLAB	GO:0004872	receptor activity	Losses
AGLAB	GO:0048244	phytanoyl-CoA dioxygenase activity	Losses
AGLAB	GO:0004630	phospholipase D activity	Losses
AGLAB	GO:0015101	organic cation transmembrane transporter activity	Losses
AGLAB	GO:0005215	transporter activity	Losses
AGLAB	GO:0060089	molecular transducer activity	Losses
AGLAB	GO:0015103	inorganic anion transmembrane transporter activity	Losses
AGLAB	GO:0003727	single-stranded RNA binding	Losses
AGLAB	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Losses
AGLAB	GO:0045289	luciferin monooxygenase activity	Losses
AGLAB	GO:0019238	cyclohydrolase activity	Losses
AGLAB	GO:0043015	gamma-tubulin binding	Losses
AGLAB	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	Losses
AGLAB	GO:0099600	transmembrane receptor activity	Losses
AGLAB	GO:0004674	protein serine/threonine kinase activity	Losses
AGLAB	GO:0004672	protein kinase activity	Losses
AGLAB	GO:0048029	monosaccharide binding	Losses
AGLAB	GO:0004620	phospholipase activity	Losses
AGLAB	GO:0031683	G-protein beta/gamma-subunit complex binding	Losses
AGLAB	GO:0002161	aminoacyl-tRNA editing activity	Losses
AGLAB	GO:0042171	lysophosphatidic acid acyltransferase activity	Losses
AGLAB	GO:0004888	transmembrane signaling receptor activity	Losses
AGLAB	GO:0000339	RNA cap binding	Losses
AGLAB	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
AGLAB	GO:0004016	adenylate cyclase activity	Losses
AGLAB	GO:0008158	hedgehog receptor activity	Losses
AGLAB	GO:0038023	signaling receptor activity	Losses
AGLAB	GO:0022892	substrate-specific transporter activity	Losses
AGLAB	GO:0009975	cyclase activity	Losses
AGLAB	GO:0005549	odorant binding	Extinctions
AGLAB	GO:0004930	G-protein coupled receptor activity	Extinctions
AGLAB	GO:0004709	MAP kinase kinase kinase activity	Extinctions
AGLAB	GO:0004871	signal transducer activity	Extinctions
AGLAB	GO:0032183	SUMO binding	Extinctions
AGLAB	GO:0004844	uracil DNA N-glycosylase activity	Extinctions
AGLAB	GO:0051428	peptide hormone receptor binding	Extinctions
AGLAB	GO:0005049	nuclear export signal receptor activity	Extinctions
AGLAB	GO:0070742	C2H2 zinc finger domain binding	Extinctions
AGLAB	GO:0016084	myostimulatory hormone activity	Extinctions
AGLAB	GO:0097506	deaminated base DNA N-glycosylase activity	Extinctions
AGLAB	GO:0000016	lactase activity	Extinctions
AGLAB	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
AGLAB	GO:0097005	adipokinetic hormone receptor binding	Extinctions
AGLAB	GO:0030145	manganese ion binding	Extinctions
AGLAB	GO:0099600	transmembrane receptor activity	Extinctions
AGLAB	GO:0004872	receptor activity	Extinctions
AGLAB	GO:0004888	transmembrane signaling receptor activity	Extinctions
AGLAB	GO:0004984	olfactory receptor activity	Extinctions
AGLAB	GO:0005184	neuropeptide hormone activity	Extinctions
AGLAB	GO:0008236	serine-type peptidase activity	Extinctions
AGLAB	GO:0017171	serine hydrolase activity	Extinctions
AGLAB	GO:0004383	guanylate cyclase activity	Extinctions
AGLAB	GO:0038023	signaling receptor activity	Extinctions
AGLAB	GO:0005534	galactose binding	Extinctions
AGLAB	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Extinctions
AGLAB	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Extinctions
AGLAB	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Extinctions
AGLAB	GO:0008384	IkappaB kinase activity	Extinctions
AGLAB	GO:0001094	TFIID-class transcription factor binding	Extinctions
AGLAB	GO:0019789	SUMO transferase activity	Extinctions
AGLAB	GO:0005315	inorganic phosphate transmembrane transporter activity	Extinctions
AGLAB	GO:0008240	tripeptidyl-peptidase activity	Extinctions
AGLAB	GO:0004446	inositol-hexakisphosphate phosphatase activity	Extinctions
AGLAB	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Extinctions
AGLAB	GO:0060089	molecular transducer activity	Extinctions
AGLAB	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
DI19	GO:0048029	monosaccharide binding	Gains
DI19	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DI19	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DI19	GO:0019798	procollagen-proline dioxygenase activity	Gains
DI19	GO:0031543	peptidyl-proline dioxygenase activity	Gains
DI19	GO:0031418	L-ascorbic acid binding	Gains
DI19	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Gains
DI19	GO:0005506	iron ion binding	Gains
DI19	GO:0031406	carboxylic acid binding	Gains
DI19	GO:0043177	organic acid binding	Gains
DI19	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Gains
DI19	GO:0030246	carbohydrate binding	Gains
DI19	GO:0017171	serine hydrolase activity	Gains
DI19	GO:0004252	serine-type endopeptidase activity	Gains
DI19	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
DI19	GO:0008236	serine-type peptidase activity	Gains
DI19	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
DI19	GO:0008233	peptidase activity	Gains
DI19	GO:0051213	dioxygenase activity	Gains
DI19	GO:0008527	taste receptor activity	Gains
DI19	GO:0004175	endopeptidase activity	Gains
DI19	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI19	GO:0019842	vitamin binding	Gains
DI19	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
DI19	GO:0140096	catalytic activity, acting on a protein	Gains
DI19	GO:0004866	endopeptidase inhibitor activity	Gains
DI19	GO:0061135	endopeptidase regulator activity	Gains
DI19	GO:0004857	enzyme inhibitor activity	Gains
DI19	GO:0005549	odorant binding	Gains
DI19	GO:0030414	peptidase inhibitor activity	Gains
DI19	GO:0004984	olfactory receptor activity	Gains
DI19	GO:0005201	extracellular matrix structural constituent	Gains
DI19	GO:0016207	4-coumarate-CoA ligase activity	Gains
DI19	GO:0004046	aminoacylase activity	Gains
DI19	GO:0005534	galactose binding	Gains
DI19	GO:0061134	peptidase regulator activity	Gains
DI19	GO:0008061	chitin binding	Gains
DI19	GO:0099600	transmembrane receptor activity	Gains
DI19	GO:0004888	transmembrane signaling receptor activity	Gains
DI19	GO:0004872	receptor activity	Gains
DI19	GO:0046914	transition metal ion binding	Gains
DI19	GO:0038023	signaling receptor activity	Gains
DI19	GO:0070001	aspartic-type peptidase activity	Gains
DI19	GO:0004190	aspartic-type endopeptidase activity	Gains
DI19	GO:0044020	histone methyltransferase activity (H4-R3 specific)	Gains
DI19	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
DI19	GO:0008378	galactosyltransferase activity	Gains
DI19	GO:0016491	oxidoreductase activity	Gains
DI19	GO:0060089	molecular transducer activity	Gains
DI19	GO:0004871	signal transducer activity	Gains
DI19	GO:0020037	heme binding	Gains
DI19	GO:0046906	tetrapyrrole binding	Gains
DI19	GO:0035250	UDP-galactosyltransferase activity	Gains
DI19	GO:0022884	macromolecule transmembrane transporter activity	Gains
DI19	GO:0022857	transmembrane transporter activity	Gains
DI19	GO:0022829	wide pore channel activity	Gains
DI19	GO:0004722	protein serine/threonine phosphatase activity	Gains
DI19	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
DI19	GO:0008484	sulfuric ester hydrolase activity	Gains
DI19	GO:0019888	protein phosphatase regulator activity	Gains
DI19	GO:0030234	enzyme regulator activity	Gains
DI19	GO:0051381	histamine binding	Gains
DI19	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
DI19	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Gains
DI19	GO:0050357	tropinesterase activity	Gains
DI19	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
DI19	GO:0008940	nitrate reductase activity	Gains
DI19	GO:0072542	protein phosphatase activator activity	Gains
DI19	GO:0005007	fibroblast growth factor-activated receptor activity	Gains
DI19	GO:0051721	protein phosphatase 2A binding	Gains
DI19	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
DI19	GO:0005355	glucose transmembrane transporter activity	Gains
DI19	GO:0008160	protein tyrosine phosphatase activator activity	Gains
DI19	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	Gains
DI19	GO:0005415	nucleoside:sodium symporter activity	Gains
DI19	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
DI19	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
DI19	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	Gains
DI19	GO:0016603	glutaminyl-peptide cyclotransferase activity	Gains
DI19	GO:0033038	bitter taste receptor activity	Gains
DI19	GO:0055077	gap junction hemi-channel activity	Gains
DI19	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity	Gains
DI19	GO:0009703	nitrate reductase (NADH) activity	Gains
DI19	GO:0032183	SUMO binding	Gains
DI19	GO:0004105	choline-phosphate cytidylyltransferase activity	Gains
DI19	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
DI19	GO:0052870	tocopherol omega-hydroxylase activity	Gains
DI19	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
DI19	GO:0008801	beta-phosphoglucomutase activity	Gains
DI19	GO:0019211	phosphatase activator activity	Gains
DI19	GO:0044325	ion channel binding	Gains
DI19	GO:0015438	teichoic-acid-transporting ATPase activity	Gains
DI19	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
DI19	GO:0015162	teichoic acid transmembrane transporter activity	Gains
DI19	GO:0004734	pyrimidodiazepine synthase activity	Gains
DI19	GO:0015140	malate transmembrane transporter activity	Gains
DI19	GO:0015145	monosaccharide transmembrane transporter activity	Gains
DI19	GO:0015149	hexose transmembrane transporter activity	Gains
DI19	GO:0015131	oxaloacetate transmembrane transporter activity	Gains
DI19	GO:0047617	acyl-CoA hydrolase activity	Gains
DI19	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
DI19	GO:0004852	uroporphyrinogen-III synthase activity	Gains
DI19	GO:0043515	kinetochore binding	Gains
DI19	GO:0018834	dichloromethane dehalogenase activity	Gains
DI19	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
DI19	GO:0004930	G-protein coupled receptor activity	Gains
DI19	GO:0050839	cell adhesion molecule binding	Losses
DI19	GO:0015103	inorganic anion transmembrane transporter activity	Losses
DI19	GO:0004725	protein tyrosine phosphatase activity	Losses
DI19	GO:0043169	cation binding	Losses
DI19	GO:0005254	chloride channel activity	Losses
DI19	GO:0001614	purinergic nucleotide receptor activity	Losses
DI19	GO:0047485	protein N-terminus binding	Losses
DI19	GO:0050840	extracellular matrix binding	Losses
DI19	GO:0016502	nucleotide receptor activity	Losses
DI19	GO:0004321	fatty-acyl-CoA synthase activity	Losses
DI19	GO:0008798	beta-aspartyl-peptidase activity	Losses
DI19	GO:0046872	metal ion binding	Losses
DI19	GO:0005253	anion channel activity	Losses
DI19	GO:0015108	chloride transmembrane transporter activity	Losses
DI19	GO:0005249	voltage-gated potassium channel activity	Losses
DI19	GO:0051020	GTPase binding	Losses
DI19	GO:0004503	monophenol monooxygenase activity	Losses
DI19	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Losses
DI19	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Losses
DI19	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
DI19	GO:0032050	clathrin heavy chain binding	Losses
DI19	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
DI19	GO:0035586	purinergic receptor activity	Losses
DI19	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
DI19	GO:0005110	frizzled-2 binding	Losses
DI19	GO:0005212	structural constituent of eye lens	Losses
DI19	GO:0003680	AT DNA binding	Losses
DI19	GO:0004736	pyruvate carboxylase activity	Losses
DI19	GO:0004833	tryptophan 2,3-dioxygenase activity	Losses
DI19	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Losses
DI19	GO:0005539	glycosaminoglycan binding	Losses
DI19	GO:0045735	nutrient reservoir activity	Losses
DI19	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Losses
DI19	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Losses
DI19	GO:0030276	clathrin binding	Losses
DI19	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	Losses
DI19	GO:0004484	mRNA guanylyltransferase activity	Losses
DI19	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Losses
DI19	GO:0004497	monooxygenase activity	Losses
DI19	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
DI19	GO:0017016	Ras GTPase binding	Losses
DI19	GO:0022843	voltage-gated cation channel activity	Losses
DI19	GO:0031267	small GTPase binding	Losses
DI19	GO:0005216	ion channel activity	Losses
DI19	GO:0022838	substrate-specific channel activity	Losses
DI19	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
DI19	GO:0004067	asparaginase activity	Losses
DI19	GO:0004075	biotin carboxylase activity	Losses
DI19	GO:0033549	MAP kinase phosphatase activity	Losses
DI19	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Losses
DI19	GO:0008192	RNA guanylyltransferase activity	Losses
DI19	GO:0050824	water binding	Losses
DI19	GO:0050825	ice binding	Losses
DI19	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
DI19	GO:0015116	sulfate transmembrane transporter activity	Losses
DI19	GO:0045289	luciferin monooxygenase activity	Losses
DI19	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
DI19	GO:0008509	anion transmembrane transporter activity	Losses
DI19	GO:0022803	passive transmembrane transporter activity	Losses
DI19	GO:0015267	channel activity	Losses
DI19	GO:0042802	identical protein binding	Losses
DI19	GO:0001614	purinergic nucleotide receptor activity	Extinctions
DI19	GO:0016502	nucleotide receptor activity	Extinctions
DI19	GO:0043169	cation binding	Extinctions
DI19	GO:0035586	purinergic receptor activity	Extinctions
DI19	GO:0004484	mRNA guanylyltransferase activity	Extinctions
DI19	GO:0046872	metal ion binding	Extinctions
DI19	GO:0008192	RNA guanylyltransferase activity	Extinctions
DI19	GO:0050824	water binding	Extinctions
DI19	GO:0050825	ice binding	Extinctions
DI19	GO:0003676	nucleic acid binding	Extinctions
DI19	GO:0008237	metallopeptidase activity	Extinctions
DI19	GO:0004687	myosin light chain kinase activity	Extinctions
DI19	GO:0032450	maltose alpha-glucosidase activity	Extinctions
DI19	GO:0003677	DNA binding	Extinctions
DI19	GO:0090599	alpha-glucosidase activity	Extinctions
DI19	GO:0070568	guanylyltransferase activity	Extinctions
DI19	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI19	GO:0004692	cGMP-dependent protein kinase activity	Extinctions
DI19	GO:0004965	G-protein coupled GABA receptor activity	Extinctions
DI19	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Extinctions
DI19	GO:0070330	aromatase activity	Extinctions
DI19	GO:0015926	glucosidase activity	Extinctions
DI19	GO:1901363	heterocyclic compound binding	Extinctions
DI19	GO:0097159	organic cyclic compound binding	Extinctions
DI17	GO:0005549	odorant binding	Gains
DI17	GO:0008061	chitin binding	Gains
DI17	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
DI17	GO:0005214	structural constituent of chitin-based cuticle	Gains
DI17	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
DI17	GO:0004984	olfactory receptor activity	Gains
DI17	GO:0004866	endopeptidase inhibitor activity	Gains
DI17	GO:0042302	structural constituent of cuticle	Gains
DI17	GO:0061135	endopeptidase regulator activity	Gains
DI17	GO:0004175	endopeptidase activity	Gains
DI17	GO:0099600	transmembrane receptor activity	Gains
DI17	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DI17	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DI17	GO:0019798	procollagen-proline dioxygenase activity	Gains
DI17	GO:0004252	serine-type endopeptidase activity	Gains
DI17	GO:0008889	glycerophosphodiester phosphodiesterase activity	Gains
DI17	GO:0017171	serine hydrolase activity	Gains
DI17	GO:0030414	peptidase inhibitor activity	Gains
DI17	GO:0004888	transmembrane signaling receptor activity	Gains
DI17	GO:0004180	carboxypeptidase activity	Gains
DI17	GO:0031543	peptidyl-proline dioxygenase activity	Gains
DI17	GO:0070851	growth factor receptor binding	Gains
DI17	GO:0008236	serine-type peptidase activity	Gains
DI17	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Gains
DI17	GO:0038023	signaling receptor activity	Gains
DI17	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI17	GO:0004872	receptor activity	Gains
DI17	GO:0004930	G-protein coupled receptor activity	Gains
DI17	GO:0008233	peptidase activity	Gains
DI17	GO:0005201	extracellular matrix structural constituent	Gains
DI17	GO:0061134	peptidase regulator activity	Gains
DI17	GO:0008237	metallopeptidase activity	Gains
DI17	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
DI17	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
DI17	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
DI17	GO:0048029	monosaccharide binding	Gains
DI17	GO:0004857	enzyme inhibitor activity	Gains
DI17	GO:0008066	glutamate receptor activity	Gains
DI17	GO:0060089	molecular transducer activity	Gains
DI17	GO:0015081	sodium ion transmembrane transporter activity	Gains
DI17	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
DI17	GO:0004222	metalloendopeptidase activity	Gains
DI17	GO:0031418	L-ascorbic acid binding	Gains
DI17	GO:0015293	symporter activity	Gains
DI17	GO:0005272	sodium channel activity	Gains
DI17	GO:0030955	potassium ion binding	Gains
DI17	GO:0031420	alkali metal ion binding	Gains
DI17	GO:0004743	pyruvate kinase activity	Gains
DI17	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Gains
DI17	GO:0001641	group II metabotropic glutamate receptor activity	Gains
DI17	GO:0046332	SMAD binding	Gains
DI17	GO:0004044	amidophosphoribosyltransferase activity	Gains
DI17	GO:0048531	beta-1,3-galactosyltransferase activity	Gains
DI17	GO:0008379	thioredoxin peroxidase activity	Gains
DI17	GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
DI17	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	Gains
DI17	GO:0016848	carbon-halide lyase activity	Gains
DI17	GO:2001070	starch binding	Gains
DI17	GO:0005246	calcium channel regulator activity	Gains
DI17	GO:0098988	G-protein coupled glutamate receptor activity	Gains
DI17	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
DI17	GO:0099094	ligand-gated cation channel activity	Gains
DI17	GO:0005326	neurotransmitter transporter activity	Gains
DI17	GO:0016247	channel regulator activity	Gains
DI17	GO:0008527	taste receptor activity	Gains
DI17	GO:0004871	signal transducer activity	Gains
DI17	GO:0015276	ligand-gated ion channel activity	Gains
DI17	GO:0022834	ligand-gated channel activity	Gains
DI17	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DI17	GO:0005184	neuropeptide hormone activity	Gains
DI17	GO:0004970	ionotropic glutamate receptor activity	Gains
DI17	GO:0022824	transmitter-gated ion channel activity	Gains
DI17	GO:0022835	transmitter-gated channel activity	Gains
DI17	GO:0005179	hormone activity	Gains
DI17	GO:0071855	neuropeptide receptor binding	Gains
DI17	GO:0004181	metallocarboxypeptidase activity	Gains
DI17	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Gains
DI17	GO:0005506	iron ion binding	Gains
DI17	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
DI17	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
DI17	GO:0022857	transmembrane transporter activity	Gains
DI17	GO:0015294	solute:cation symporter activity	Gains
DI17	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Gains
DI17	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
DI17	GO:0005154	epidermal growth factor receptor binding	Gains
DI17	GO:0005158	insulin receptor binding	Gains
DI17	GO:0015179	L-amino acid transmembrane transporter activity	Gains
DI17	GO:0009881	photoreceptor activity	Gains
DI17	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI17	GO:0034061	DNA polymerase activity	Losses
DI17	GO:0046872	metal ion binding	Losses
DI17	GO:0043169	cation binding	Losses
DI17	GO:0140097	catalytic activity, acting on DNA	Losses
DI17	GO:0008270	zinc ion binding	Losses
DI17	GO:0046914	transition metal ion binding	Losses
DI17	GO:0043167	ion binding	Losses
DI17	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
DI17	GO:0009378	four-way junction helicase activity	Losses
DI17	GO:0003676	nucleic acid binding	Losses
DI17	GO:0016779	nucleotidyltransferase activity	Losses
DI17	GO:0004871	signal transducer activity	Losses
DI17	GO:0060089	molecular transducer activity	Losses
DI17	GO:0003707	steroid hormone receptor activity	Losses
DI17	GO:0004872	receptor activity	Losses
DI17	GO:0003960	NADPH:quinone reductase activity	Losses
DI17	GO:0008233	peptidase activity	Losses
DI17	GO:0008307	structural constituent of muscle	Losses
DI17	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Losses
DI17	GO:0038023	signaling receptor activity	Losses
DI17	GO:0004190	aspartic-type endopeptidase activity	Losses
DI17	GO:0070001	aspartic-type peptidase activity	Losses
DI17	GO:0004518	nuclease activity	Losses
DI17	GO:0016301	kinase activity	Losses
DI17	GO:0004672	protein kinase activity	Losses
DI17	GO:0097159	organic cyclic compound binding	Losses
DI17	GO:0004519	endonuclease activity	Losses
DI17	GO:0016787	hydrolase activity	Losses
DI17	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI17	GO:0046872	metal ion binding	Extinctions
DI17	GO:0043169	cation binding	Extinctions
DI17	GO:0003676	nucleic acid binding	Extinctions
DI17	GO:0034061	DNA polymerase activity	Extinctions
DI17	GO:0140097	catalytic activity, acting on DNA	Extinctions
DI17	GO:0008270	zinc ion binding	Extinctions
DI17	GO:0046914	transition metal ion binding	Extinctions
DI17	GO:0009378	four-way junction helicase activity	Extinctions
DI17	GO:0003960	NADPH:quinone reductase activity	Extinctions
DI17	GO:0043167	ion binding	Extinctions
DI17	GO:0016779	nucleotidyltransferase activity	Extinctions
DI17	GO:1901363	heterocyclic compound binding	Extinctions
DI17	GO:0097159	organic cyclic compound binding	Extinctions
DI17	GO:0016499	orexin receptor activity	Extinctions
DI17	GO:0018580	nitronate monooxygenase activity	Extinctions
DI17	GO:0033867	Fas-activated serine/threonine kinase activity	Extinctions
DI17	GO:0047407	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	Extinctions
DI17	GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity	Extinctions
DI17	GO:0008746	NAD(P)+ transhydrogenase activity	Extinctions
DI17	GO:0035529	NADH pyrophosphatase activity	Extinctions
DI17	GO:0016652	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor	Extinctions
DI17	GO:0033904	dextranase activity	Extinctions
DI17	GO:0047874	dolichyldiphosphatase activity	Extinctions
DI17	GO:0045480	galactose oxidase activity	Extinctions
DI17	GO:0004528	phosphodiesterase I activity	Extinctions
DI17	GO:0004677	DNA-dependent protein kinase activity	Extinctions
DI17	GO:0008986	pyruvate, water dikinase activity	Extinctions
DI17	GO:0004871	signal transducer activity	Extinctions
DI17	GO:0070403	NAD+ binding	Extinctions
DI17	GO:0000155	phosphorelay sensor kinase activity	Extinctions
DI17	GO:0004673	protein histidine kinase activity	Extinctions
DI15	GO:0005549	odorant binding	Gains
DI15	GO:0005544	calcium-dependent phospholipid binding	Gains
DI15	GO:0003964	RNA-directed DNA polymerase activity	Gains
DI15	GO:0004984	olfactory receptor activity	Gains
DI15	GO:0005509	calcium ion binding	Gains
DI15	GO:0015020	glucuronosyltransferase activity	Gains
DI15	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
DI15	GO:0038023	signaling receptor activity	Gains
DI15	GO:0003677	DNA binding	Gains
DI15	GO:0034061	DNA polymerase activity	Gains
DI15	GO:0004872	receptor activity	Gains
DI15	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
DI15	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
DI15	GO:0003676	nucleic acid binding	Gains
DI15	GO:0004871	signal transducer activity	Gains
DI15	GO:0099600	transmembrane receptor activity	Gains
DI15	GO:0004888	transmembrane signaling receptor activity	Gains
DI15	GO:0060089	molecular transducer activity	Gains
DI15	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
DI15	GO:0003700	DNA binding transcription factor activity	Gains
DI15	GO:0043565	sequence-specific DNA binding	Gains
DI15	GO:0004252	serine-type endopeptidase activity	Gains
DI15	GO:0004175	endopeptidase activity	Gains
DI15	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
DI15	GO:0140097	catalytic activity, acting on DNA	Gains
DI15	GO:0016832	aldehyde-lyase activity	Gains
DI15	GO:0004993	G-protein coupled serotonin receptor activity	Gains
DI15	GO:0099589	serotonin receptor activity	Gains
DI15	GO:0000976	transcription regulatory region sequence-specific DNA binding	Gains
DI15	GO:0044212	transcription regulatory region DNA binding	Gains
DI15	GO:0005201	extracellular matrix structural constituent	Gains
DI15	GO:0000975	regulatory region DNA binding	Gains
DI15	GO:0001067	regulatory region nucleic acid binding	Gains
DI15	GO:0016779	nucleotidyltransferase activity	Gains
DI15	GO:0004965	G-protein coupled GABA receptor activity	Gains
DI15	GO:0015491	cation:cation antiporter activity	Gains
DI15	GO:0004190	aspartic-type endopeptidase activity	Gains
DI15	GO:0070001	aspartic-type peptidase activity	Gains
DI15	GO:0022838	substrate-specific channel activity	Gains
DI15	GO:1990837	sequence-specific double-stranded DNA binding	Gains
DI15	GO:0008236	serine-type peptidase activity	Gains
DI15	GO:0016160	amylase activity	Gains
DI15	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
DI15	GO:0004793	threonine aldolase activity	Gains
DI15	GO:0097493	structural molecule activity conferring elasticity	Gains
DI15	GO:0016231	beta-N-acetylglucosaminidase activity	Gains
DI15	GO:0008508	bile acid:sodium symporter activity	Gains
DI15	GO:0004735	pyrroline-5-carboxylate reductase activity	Gains
DI15	GO:0070379	high mobility group box 1 binding	Gains
DI15	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Gains
DI15	GO:0097109	neuroligin family protein binding	Gains
DI15	GO:0034185	apolipoprotein binding	Gains
DI15	GO:0030366	molybdopterin synthase activity	Gains
DI15	GO:0004556	alpha-amylase activity	Gains
DI15	GO:0003935	GTP cyclohydrolase II activity	Gains
DI15	GO:0001587	Gq/11-coupled serotonin receptor activity	Gains
DI15	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Gains
DI15	GO:0008903	hydroxypyruvate isomerase activity	Gains
DI15	GO:0004097	catechol oxidase activity	Gains
DI15	GO:0009378	four-way junction helicase activity	Gains
DI15	GO:0036263	L-DOPA monooxygenase activity	Gains
DI15	GO:0036264	dopamine monooxygenase activity	Gains
DI15	GO:0008331	high voltage-gated calcium channel activity	Gains
DI15	GO:0033932	1,3-alpha-L-fucosidase activity	Gains
DI15	GO:0015125	bile acid transmembrane transporter activity	Gains
DI15	GO:0005372	water transmembrane transporter activity	Gains
DI15	GO:0047886	farnesol dehydrogenase activity	Gains
DI15	GO:0015250	water channel activity	Gains
DI15	GO:0017171	serine hydrolase activity	Gains
DI15	GO:0022803	passive transmembrane transporter activity	Gains
DI15	GO:0015267	channel activity	Gains
DI15	GO:0004104	cholinesterase activity	Gains
DI15	GO:0015081	sodium ion transmembrane transporter activity	Gains
DI15	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
DI15	GO:0022836	gated channel activity	Gains
DI15	GO:0033613	activating transcription factor binding	Gains
DI15	GO:0016917	GABA receptor activity	Gains
DI15	GO:0099516	ion antiporter activity	Gains
DI15	GO:0004930	G-protein coupled receptor activity	Gains
DI15	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
DI15	GO:0015298	solute:cation antiporter activity	Gains
DI15	GO:0043015	gamma-tubulin binding	Losses
DI15	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI15	GO:0003756	protein disulfide isomerase activity	Losses
DI15	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	Losses
DI15	GO:0003796	lysozyme activity	Losses
DI15	GO:0016853	isomerase activity	Losses
DI15	GO:0004984	olfactory receptor activity	Losses
DI15	GO:0016860	intramolecular oxidoreductase activity	Losses
DI15	GO:0016866	intramolecular transferase activity	Losses
DI15	GO:0034061	DNA polymerase activity	Losses
DI15	GO:0052745	inositol phosphate phosphatase activity	Losses
DI15	GO:0008527	taste receptor activity	Losses
DI15	GO:0003993	acid phosphatase activity	Losses
DI15	GO:0015217	ADP transmembrane transporter activity	Losses
DI15	GO:0005471	ATP:ADP antiporter activity	Losses
DI15	GO:0004346	glucose-6-phosphatase activity	Losses
DI15	GO:0050112	inositol 2-dehydrogenase activity	Losses
DI15	GO:0005122	torso binding	Losses
DI15	GO:1900750	oligopeptide binding	Losses
DI15	GO:0008835	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	Losses
DI15	GO:0008801	beta-phosphoglucomutase activity	Losses
DI15	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Losses
DI15	GO:0004557	alpha-galactosidase activity	Losses
DI15	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Losses
DI15	GO:0017128	phospholipid scramblase activity	Losses
DI15	GO:0016503	pheromone receptor activity	Losses
DI15	GO:0052692	raffinose alpha-galactosidase activity	Losses
DI15	GO:0036401	pyrokinin receptor activity	Losses
DI15	GO:0070742	C2H2 zinc finger domain binding	Losses
DI15	GO:0018445	prothoracicotrophic hormone activity	Losses
DI15	GO:0004055	argininosuccinate synthase activity	Losses
DI15	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Losses
DI15	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
DI15	GO:0050309	sugar-terminal-phosphatase activity	Losses
DI15	GO:0005347	ATP transmembrane transporter activity	Losses
DI15	GO:0043295	glutathione binding	Losses
DI15	GO:0003677	DNA binding	Losses
DI15	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
DI15	GO:0003713	transcription coactivator activity	Losses
DI15	GO:0009982	pseudouridine synthase activity	Losses
DI15	GO:0061783	peptidoglycan muralytic activity	Losses
DI15	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
DI15	GO:0008376	acetylgalactosaminyltransferase activity	Losses
DI15	GO:0004129	cytochrome-c oxidase activity	Losses
DI15	GO:0015002	heme-copper terminal oxidase activity	Losses
DI15	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
DI15	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
DI15	GO:0140097	catalytic activity, acting on DNA	Losses
DI15	GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
DI15	GO:0004736	pyruvate carboxylase activity	Losses
DI15	GO:0046423	allene-oxide cyclase activity	Losses
DI15	GO:0022833	mechanically gated channel activity	Losses
DI15	GO:0003998	acylphosphatase activity	Losses
DI15	GO:0015088	copper uptake transmembrane transporter activity	Losses
DI15	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
DI15	GO:0003913	DNA photolyase activity	Losses
DI15	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
DI15	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
DI15	GO:0052834	inositol monophosphate phosphatase activity	Losses
DI15	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Losses
DI15	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
DI15	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
DI15	GO:0001607	neuromedin U receptor activity	Losses
DI15	GO:0015301	anion:anion antiporter activity	Losses
DI15	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
DI15	GO:0008381	mechanically-gated ion channel activity	Losses
DI15	GO:0043425	bHLH transcription factor binding	Losses
DI15	GO:0001094	TFIID-class transcription factor binding	Losses
DI15	GO:0015035	protein disulfide oxidoreductase activity	Losses
DI15	GO:0004346	glucose-6-phosphatase activity	Extinctions
DI15	GO:1900750	oligopeptide binding	Extinctions
DI15	GO:0004055	argininosuccinate synthase activity	Extinctions
DI15	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Extinctions
DI15	GO:0050309	sugar-terminal-phosphatase activity	Extinctions
DI15	GO:0043295	glutathione binding	Extinctions
DI15	GO:0004446	inositol-hexakisphosphate phosphatase activity	Extinctions
DI15	GO:0046423	allene-oxide cyclase activity	Extinctions
DI15	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Extinctions
DI15	GO:0003913	DNA photolyase activity	Extinctions
DI15	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Extinctions
DI15	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
DI15	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Extinctions
DI15	GO:0004594	pantothenate kinase activity	Extinctions
DI15	GO:0050308	sugar-phosphatase activity	Extinctions
DI15	GO:0003910	DNA ligase (ATP) activity	Extinctions
DI15	GO:0003713	transcription coactivator activity	Extinctions
DI15	GO:0005109	frizzled binding	Extinctions
DI15	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Extinctions
DI15	GO:0003909	DNA ligase activity	Extinctions
DI15	GO:0008430	selenium binding	Extinctions
DI13	GO:0046914	transition metal ion binding	Gains
DI13	GO:0008270	zinc ion binding	Gains
DI13	GO:0016615	malate dehydrogenase activity	Gains
DI13	GO:0046872	metal ion binding	Gains
DI13	GO:0043169	cation binding	Gains
DI13	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Gains
DI13	GO:0004866	endopeptidase inhibitor activity	Gains
DI13	GO:0061135	endopeptidase regulator activity	Gains
DI13	GO:0070330	aromatase activity	Gains
DI13	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
DI13	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
DI13	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Gains
DI13	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Gains
DI13	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Gains
DI13	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
DI13	GO:0004559	alpha-mannosidase activity	Gains
DI13	GO:0030414	peptidase inhibitor activity	Gains
DI13	GO:0004857	enzyme inhibitor activity	Gains
DI13	GO:0005507	copper ion binding	Gains
DI13	GO:0003696	satellite DNA binding	Gains
DI13	GO:0030060	L-malate dehydrogenase activity	Gains
DI13	GO:0015923	mannosidase activity	Gains
DI13	GO:0016229	steroid dehydrogenase activity	Gains
DI13	GO:0004190	aspartic-type endopeptidase activity	Gains
DI13	GO:0070001	aspartic-type peptidase activity	Gains
DI13	GO:0061134	peptidase regulator activity	Gains
DI13	GO:0019201	nucleotide kinase activity	Gains
DI13	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Gains
DI13	GO:0004017	adenylate kinase activity	Gains
DI13	GO:0004303	estradiol 17-beta-dehydrogenase activity	Gains
DI13	GO:0004497	monooxygenase activity	Gains
DI13	GO:0019205	nucleobase-containing compound kinase activity	Gains
DI13	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	Gains
DI13	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
DI13	GO:0019206	nucleoside kinase activity	Gains
DI13	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
DI13	GO:0003964	RNA-directed DNA polymerase activity	Gains
DI13	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
DI13	GO:0043167	ion binding	Gains
DI13	GO:0004415	hyalurononglucosaminidase activity	Gains
DI13	GO:0035198	miRNA binding	Gains
DI13	GO:0004164	diphthine synthase activity	Gains
DI13	GO:0005275	amine transmembrane transporter activity	Gains
DI13	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
DI13	GO:0004131	cytosine deaminase activity	Gains
DI13	GO:0004105	choline-phosphate cytidylyltransferase activity	Gains
DI13	GO:0004108	citrate (Si)-synthase activity	Gains
DI13	GO:0008836	diaminopimelate decarboxylase activity	Gains
DI13	GO:0080023	3R-hydroxyacyl-CoA dehydratase activity	Gains
DI13	GO:0016603	glutaminyl-peptide cyclotransferase activity	Gains
DI13	GO:0036440	citrate synthase activity	Gains
DI13	GO:0004586	ornithine decarboxylase activity	Gains
DI13	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
DI13	GO:0004516	nicotinate phosphoribosyltransferase activity	Gains
DI13	GO:0016936	galactoside binding	Gains
DI13	GO:0032454	histone demethylase activity (H3-K9 specific)	Gains
DI13	GO:0008046	axon guidance receptor activity	Gains
DI13	GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity	Gains
DI13	GO:0005094	Rho GDP-dissociation inhibitor activity	Gains
DI13	GO:0015250	water channel activity	Gains
DI13	GO:0070379	high mobility group box 1 binding	Gains
DI13	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
DI13	GO:0052870	tocopherol omega-hydroxylase activity	Gains
DI13	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
DI13	GO:0004062	aryl sulfotransferase activity	Gains
DI13	GO:0004027	alcohol sulfotransferase activity	Gains
DI13	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
DI13	GO:0005372	water transmembrane transporter activity	Gains
DI13	GO:0004369	glycerol-3-phosphate oxidase activity	Gains
DI13	GO:0004352	glutamate dehydrogenase (NAD+) activity	Gains
DI13	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Gains
DI13	GO:0004372	glycine hydroxymethyltransferase activity	Gains
DI13	GO:0005430	synaptic vesicle amine transmembrane transporter activity	Gains
DI13	GO:0036082	extracellular phenylacetaldehyde-gated ion channel activity	Gains
DI13	GO:0004304	estrone sulfotransferase activity	Gains
DI13	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Gains
DI13	GO:0018024	histone-lysine N-methyltransferase activity	Gains
DI13	GO:0016278	lysine N-methyltransferase activity	Gains
DI13	GO:0016279	protein-lysine N-methyltransferase activity	Gains
DI13	GO:0022824	transmitter-gated ion channel activity	Losses
DI13	GO:0022835	transmitter-gated channel activity	Losses
DI13	GO:0004970	ionotropic glutamate receptor activity	Losses
DI13	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
DI13	GO:0004180	carboxypeptidase activity	Losses
DI13	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
DI13	GO:0008238	exopeptidase activity	Losses
DI13	GO:0008066	glutamate receptor activity	Losses
DI13	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
DI13	GO:0048531	beta-1,3-galactosyltransferase activity	Losses
DI13	GO:0003680	AT DNA binding	Losses
DI13	GO:0050591	quinine 3-monooxygenase activity	Losses
DI13	GO:2001070	starch binding	Losses
DI13	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	Losses
DI13	GO:0030594	neurotransmitter receptor activity	Losses
DI13	GO:0004602	glutathione peroxidase activity	Losses
DI13	GO:0005506	iron ion binding	Losses
DI13	GO:0008241	peptidyl-dipeptidase activity	Losses
DI13	GO:0045735	nutrient reservoir activity	Losses
DI13	GO:0004771	sterol esterase activity	Losses
DI13	GO:0046914	transition metal ion binding	Losses
DI13	GO:0008061	chitin binding	Losses
DI13	GO:0005230	extracellular ligand-gated ion channel activity	Losses
DI13	GO:0004806	triglyceride lipase activity	Losses
DI13	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DI13	GO:0008233	peptidase activity	Losses
DI13	GO:0001871	pattern binding	Losses
DI13	GO:0030247	polysaccharide binding	Losses
DI13	GO:0016853	isomerase activity	Losses
DI13	GO:0008889	glycerophosphodiester phosphodiesterase activity	Losses
DI13	GO:0004971	AMPA glutamate receptor activity	Losses
DI13	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI13	GO:0008237	metallopeptidase activity	Losses
DI13	GO:0009982	pseudouridine synthase activity	Losses
DI13	GO:0016803	ether hydrolase activity	Losses
DI13	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
DI13	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DI13	GO:0022834	ligand-gated channel activity	Losses
DI13	GO:0015276	ligand-gated ion channel activity	Losses
DI13	GO:0052689	carboxylic ester hydrolase activity	Losses
DI13	GO:0005216	ion channel activity	Losses
DI13	GO:0008195	phosphatidate phosphatase activity	Losses
DI13	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
DI13	GO:0022838	substrate-specific channel activity	Losses
DI13	GO:0004190	aspartic-type endopeptidase activity	Losses
DI13	GO:0070001	aspartic-type peptidase activity	Losses
DI13	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
DI13	GO:0022803	passive transmembrane transporter activity	Losses
DI13	GO:0015267	channel activity	Losses
DI13	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
DI13	GO:0038023	signaling receptor activity	Losses
DI13	GO:0008270	zinc ion binding	Losses
DI13	GO:0008378	galactosyltransferase activity	Losses
DI13	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
DI13	GO:0042947	glucoside transmembrane transporter activity	Losses
DI13	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
DI13	GO:0050357	tropinesterase activity	Losses
DI13	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Losses
DI13	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Losses
DI13	GO:0008774	acetaldehyde dehydrogenase (acetylating) activity	Losses
DI13	GO:0005225	volume-sensitive anion channel activity	Losses
DI13	GO:0017159	pantetheine hydrolase activity	Losses
DI13	GO:0015026	coreceptor activity	Losses
DI13	GO:0070576	vitamin D 24-hydroxylase activity	Losses
DI13	GO:0070513	death domain binding	Losses
DI13	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
DI13	GO:0004796	thromboxane-A synthase activity	Losses
DI13	GO:0004782	sulfinoalanine decarboxylase activity	Losses
DI13	GO:0004747	ribokinase activity	Losses
DI13	GO:0004865	protein serine/threonine phosphatase inhibitor activity	Losses
DI13	GO:0004850	uridine phosphorylase activity	Losses
DI13	GO:0001758	retinal dehydrogenase activity	Losses
DI13	GO:0004807	triose-phosphate isomerase activity	Losses
DI13	GO:0016034	maleylacetoacetate isomerase activity	Losses
DI13	GO:0070976	TIR domain binding	Losses
DI13	GO:0003911	DNA ligase (NAD+) activity	Losses
DI13	GO:0008093	cytoskeletal adaptor activity	Losses
DI13	GO:0050840	extracellular matrix binding	Losses
DI13	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
DI13	GO:0008967	phosphoglycolate phosphatase activity	Losses
DI13	GO:0015245	fatty acid transporter activity	Losses
DI13	GO:0047747	cholate-CoA ligase activity	Losses
DI13	GO:0018833	DDT-dehydrochlorinase activity	Losses
DI13	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	Losses
DI13	GO:0004068	aspartate 1-decarboxylase activity	Losses
DI13	GO:0030544	Hsp70 protein binding	Losses
DI13	GO:0008495	protoheme IX farnesyltransferase activity	Losses
DI13	GO:0015574	trehalose transmembrane transporter activity	Losses
DI13	GO:0072320	volume-sensitive chloride channel activity	Losses
DI13	GO:0005324	long-chain fatty acid transporter activity	Losses
DI13	GO:0004351	glutamate decarboxylase activity	Losses
DI13	GO:0005436	sodium:phosphate symporter activity	Losses
DI13	GO:0004334	fumarylacetoacetase activity	Losses
DI13	GO:0004301	epoxide hydrolase activity	Losses
DI13	GO:0022857	transmembrane transporter activity	Losses
DI13	GO:0008061	chitin binding	Extinctions
DI13	GO:0008241	peptidyl-dipeptidase activity	Extinctions
DI13	GO:0004180	carboxypeptidase activity	Extinctions
DI13	GO:0009982	pseudouridine synthase activity	Extinctions
DI13	GO:0008238	exopeptidase activity	Extinctions
DI13	GO:0022824	transmitter-gated ion channel activity	Extinctions
DI13	GO:0022835	transmitter-gated channel activity	Extinctions
DI13	GO:0004970	ionotropic glutamate receptor activity	Extinctions
DI13	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
DI13	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
DI13	GO:0008066	glutamate receptor activity	Extinctions
DI13	GO:0016866	intramolecular transferase activity	Extinctions
DI13	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Extinctions
DI13	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Extinctions
DI13	GO:0070513	death domain binding	Extinctions
DI13	GO:0004865	protein serine/threonine phosphatase inhibitor activity	Extinctions
DI13	GO:0004807	triose-phosphate isomerase activity	Extinctions
DI13	GO:0003911	DNA ligase (NAD+) activity	Extinctions
DI13	GO:0008093	cytoskeletal adaptor activity	Extinctions
DI13	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	Extinctions
DI13	GO:0030544	Hsp70 protein binding	Extinctions
DI13	GO:0008495	protoheme IX farnesyltransferase activity	Extinctions
DI13	GO:0004334	fumarylacetoacetase activity	Extinctions
DI13	GO:0030594	neurotransmitter receptor activity	Extinctions
DI13	GO:0001871	pattern binding	Extinctions
DI13	GO:0030247	polysaccharide binding	Extinctions
DI13	GO:0046914	transition metal ion binding	Extinctions
DI11	GO:0008527	taste receptor activity	Gains
DI11	GO:0099600	transmembrane receptor activity	Gains
DI11	GO:0004888	transmembrane signaling receptor activity	Gains
DI11	GO:0004872	receptor activity	Gains
DI11	GO:0060089	molecular transducer activity	Gains
DI11	GO:0038023	signaling receptor activity	Gains
DI11	GO:0004871	signal transducer activity	Gains
DI11	GO:0005549	odorant binding	Gains
DI11	GO:0008061	chitin binding	Gains
DI11	GO:0004930	G-protein coupled receptor activity	Gains
DI11	GO:0030246	carbohydrate binding	Gains
DI11	GO:0004857	enzyme inhibitor activity	Gains
DI11	GO:0048029	monosaccharide binding	Gains
DI11	GO:0022834	ligand-gated channel activity	Gains
DI11	GO:0015276	ligand-gated ion channel activity	Gains
DI11	GO:0004984	olfactory receptor activity	Gains
DI11	GO:0030414	peptidase inhibitor activity	Gains
DI11	GO:0003964	RNA-directed DNA polymerase activity	Gains
DI11	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DI11	GO:0030594	neurotransmitter receptor activity	Gains
DI11	GO:0004970	ionotropic glutamate receptor activity	Gains
DI11	GO:0022824	transmitter-gated ion channel activity	Gains
DI11	GO:0022835	transmitter-gated channel activity	Gains
DI11	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
DI11	GO:0022836	gated channel activity	Gains
DI11	GO:0061134	peptidase regulator activity	Gains
DI11	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
DI11	GO:0005216	ion channel activity	Gains
DI11	GO:0022838	substrate-specific channel activity	Gains
DI11	GO:0008066	glutamate receptor activity	Gains
DI11	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
DI11	GO:0031418	L-ascorbic acid binding	Gains
DI11	GO:0004568	chitinase activity	Gains
DI11	GO:0005534	galactose binding	Gains
DI11	GO:0022803	passive transmembrane transporter activity	Gains
DI11	GO:0015267	channel activity	Gains
DI11	GO:0004866	endopeptidase inhibitor activity	Gains
DI11	GO:0015075	ion transmembrane transporter activity	Gains
DI11	GO:0061135	endopeptidase regulator activity	Gains
DI11	GO:0022857	transmembrane transporter activity	Gains
DI11	GO:0042162	telomeric DNA binding	Gains
DI11	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
DI11	GO:0022891	substrate-specific transmembrane transporter activity	Gains
DI11	GO:0034061	DNA polymerase activity	Gains
DI11	GO:0005215	transporter activity	Gains
DI11	GO:0030234	enzyme regulator activity	Gains
DI11	GO:0043177	organic acid binding	Gains
DI11	GO:0031406	carboxylic acid binding	Gains
DI11	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
DI11	GO:0005343	organic acid:sodium symporter activity	Gains
DI11	GO:0022892	substrate-specific transporter activity	Gains
DI11	GO:0140097	catalytic activity, acting on DNA	Gains
DI11	GO:0004971	AMPA glutamate receptor activity	Gains
DI11	GO:0090599	alpha-glucosidase activity	Gains
DI11	GO:0015002	heme-copper terminal oxidase activity	Gains
DI11	GO:0004129	cytochrome-c oxidase activity	Gains
DI11	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
DI11	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
DI11	GO:0098772	molecular function regulator	Gains
DI11	GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
DI11	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
DI11	GO:0019208	phosphatase regulator activity	Gains
DI11	GO:0019798	procollagen-proline dioxygenase activity	Gains
DI11	GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
DI11	GO:0004965	G-protein coupled GABA receptor activity	Losses
DI11	GO:0016917	GABA receptor activity	Losses
DI11	GO:0017124	SH3 domain binding	Losses
DI11	GO:0004993	G-protein coupled serotonin receptor activity	Losses
DI11	GO:0099589	serotonin receptor activity	Losses
DI11	GO:0005544	calcium-dependent phospholipid binding	Losses
DI11	GO:0003707	steroid hormone receptor activity	Losses
DI11	GO:0051287	NAD binding	Losses
DI11	GO:0001642	group III metabotropic glutamate receptor activity	Losses
DI11	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Losses
DI11	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Losses
DI11	GO:0008331	high voltage-gated calcium channel activity	Losses
DI11	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Losses
DI11	GO:0008459	chondroitin 6-sulfotransferase activity	Losses
DI11	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Losses
DI11	GO:0016231	beta-N-acetylglucosaminidase activity	Losses
DI11	GO:0008115	sarcosine oxidase activity	Losses
DI11	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Losses
DI11	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
DI11	GO:0042954	lipoprotein transporter activity	Losses
DI11	GO:0016595	glutamate binding	Losses
DI11	GO:0015026	coreceptor activity	Losses
DI11	GO:0008747	N-acetylneuraminate lyase activity	Losses
DI11	GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	Losses
DI11	GO:0030366	molybdopterin synthase activity	Losses
DI11	GO:0030350	iron-responsive element binding	Losses
DI11	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
DI11	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Losses
DI11	GO:0001872	(1->3)-beta-D-glucan binding	Losses
DI11	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Losses
DI11	GO:0003935	GTP cyclohydrolase II activity	Losses
DI11	GO:0070976	TIR domain binding	Losses
DI11	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
DI11	GO:0001587	Gq/11-coupled serotonin receptor activity	Losses
DI11	GO:0047200	tetrahydrodipicolinate N-acetyltransferase activity	Losses
DI11	GO:0008974	phosphoribulokinase activity	Losses
DI11	GO:0019904	protein domain specific binding	Losses
DI11	GO:0016247	channel regulator activity	Losses
DI11	GO:0030246	carbohydrate binding	Losses
DI11	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
DI11	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
DI11	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
DI11	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
DI11	GO:0003676	nucleic acid binding	Losses
DI11	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Losses
DI11	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
DI11	GO:0016836	hydro-lyase activity	Losses
DI11	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Losses
DI11	GO:0001641	group II metabotropic glutamate receptor activity	Losses
DI11	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
DI11	GO:0009378	four-way junction helicase activity	Losses
DI11	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity	Losses
DI11	GO:0008332	low voltage-gated calcium channel activity	Losses
DI11	GO:0016149	translation release factor activity, codon specific	Losses
DI11	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
DI11	GO:0005314	high-affinity glutamate transmembrane transporter activity	Losses
DI11	GO:0004363	glutathione synthase activity	Losses
DI11	GO:0016833	oxo-acid-lyase activity	Losses
DI11	GO:0034481	chondroitin sulfotransferase activity	Losses
DI11	GO:0015928	fucosidase activity	Losses
DI11	GO:0070546	L-phenylalanine aminotransferase activity	Losses
DI11	GO:0030331	estrogen receptor binding	Losses
DI11	GO:0098988	G-protein coupled glutamate receptor activity	Losses
DI11	GO:0004833	tryptophan 2,3-dioxygenase activity	Losses
DI11	GO:0015485	cholesterol binding	Losses
DI11	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Losses
DI11	GO:0004560	alpha-L-fucosidase activity	Losses
DI11	GO:0003994	aconitate hydratase activity	Losses
DI11	GO:0003954	NADH dehydrogenase activity	Losses
DI11	GO:0043167	ion binding	Extinctions
DI11	GO:0016247	channel regulator activity	Extinctions
DI11	GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
DI11	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Extinctions
DI11	GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
DI11	GO:0042954	lipoprotein transporter activity	Extinctions
DI11	GO:0016595	glutamate binding	Extinctions
DI11	GO:0008747	N-acetylneuraminate lyase activity	Extinctions
DI11	GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	Extinctions
DI11	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Extinctions
DI11	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Extinctions
DI11	GO:0003935	GTP cyclohydrolase II activity	Extinctions
DI11	GO:0047200	tetrahydrodipicolinate N-acetyltransferase activity	Extinctions
DI11	GO:0008974	phosphoribulokinase activity	Extinctions
DI11	GO:0017111	nucleoside-triphosphatase activity	Extinctions
DI11	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
DI11	GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
DI11	GO:0009378	four-way junction helicase activity	Extinctions
DI11	GO:0016833	oxo-acid-lyase activity	Extinctions
DI11	GO:0030331	estrogen receptor binding	Extinctions
DI11	GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
DI11	GO:0015485	cholesterol binding	Extinctions
DI11	GO:0016462	pyrophosphatase activity	Extinctions
DI11	GO:0043177	organic acid binding	Extinctions
DI11	GO:0031406	carboxylic acid binding	Extinctions
DI11	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Extinctions
DI11	GO:0016817	hydrolase activity, acting on acid anhydrides	Extinctions
DI11	GO:0043023	ribosomal large subunit binding	Extinctions
DI11	GO:0003933	GTP cyclohydrolase activity	Extinctions
DI11	GO:0003939	L-iditol 2-dehydrogenase activity	Extinctions
DI11	GO:0005524	ATP binding	Extinctions
DI11	GO:0032559	adenyl ribonucleotide binding	Extinctions
GBUEN	GO:0003964	RNA-directed DNA polymerase activity	Gains
GBUEN	GO:0034061	DNA polymerase activity	Gains
GBUEN	GO:0140097	catalytic activity, acting on DNA	Gains
GBUEN	GO:0016779	nucleotidyltransferase activity	Gains
GBUEN	GO:0070001	aspartic-type peptidase activity	Gains
GBUEN	GO:0004190	aspartic-type endopeptidase activity	Gains
GBUEN	GO:0005549	odorant binding	Gains
GBUEN	GO:0008270	zinc ion binding	Gains
GBUEN	GO:0046914	transition metal ion binding	Gains
GBUEN	GO:0043169	cation binding	Gains
GBUEN	GO:0046872	metal ion binding	Gains
GBUEN	GO:0003676	nucleic acid binding	Gains
GBUEN	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GBUEN	GO:0004175	endopeptidase activity	Gains
GBUEN	GO:0004518	nuclease activity	Gains
GBUEN	GO:0004629	phospholipase C activity	Gains
GBUEN	GO:0004984	olfactory receptor activity	Gains
GBUEN	GO:0004519	endonuclease activity	Gains
GBUEN	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GBUEN	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
GBUEN	GO:0008233	peptidase activity	Gains
GBUEN	GO:0097159	organic cyclic compound binding	Gains
GBUEN	GO:1901363	heterocyclic compound binding	Gains
GBUEN	GO:0003697	single-stranded DNA binding	Gains
GBUEN	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
GBUEN	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
GBUEN	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
GBUEN	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
GBUEN	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
GBUEN	GO:0004833	tryptophan 2,3-dioxygenase activity	Gains
GBUEN	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
GBUEN	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
GBUEN	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
GBUEN	GO:0004503	monophenol monooxygenase activity	Gains
GBUEN	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
GBUEN	GO:0008241	peptidyl-dipeptidase activity	Gains
GBUEN	GO:0004784	superoxide dismutase activity	Gains
GBUEN	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Gains
GBUEN	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GBUEN	GO:0003678	DNA helicase activity	Gains
GBUEN	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
GBUEN	GO:0017048	Rho GTPase binding	Gains
GBUEN	GO:0004888	transmembrane signaling receptor activity	Losses
GBUEN	GO:0038023	signaling receptor activity	Losses
GBUEN	GO:0060089	molecular transducer activity	Losses
GBUEN	GO:0099600	transmembrane receptor activity	Losses
GBUEN	GO:0004871	signal transducer activity	Losses
GBUEN	GO:0004872	receptor activity	Losses
GBUEN	GO:0016298	lipase activity	Losses
GBUEN	GO:0008066	glutamate receptor activity	Losses
GBUEN	GO:0052689	carboxylic ester hydrolase activity	Losses
GBUEN	GO:0008484	sulfuric ester hydrolase activity	Losses
GBUEN	GO:0004930	G-protein coupled receptor activity	Losses
GBUEN	GO:0004970	ionotropic glutamate receptor activity	Losses
GBUEN	GO:0022824	transmitter-gated ion channel activity	Losses
GBUEN	GO:0022835	transmitter-gated channel activity	Losses
GBUEN	GO:0004806	triglyceride lipase activity	Losses
GBUEN	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
GBUEN	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GBUEN	GO:0140096	catalytic activity, acting on a protein	Losses
GBUEN	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GBUEN	GO:0101005	ubiquitinyl hydrolase activity	Losses
GBUEN	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
GBUEN	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
GBUEN	GO:0035586	purinergic receptor activity	Losses
GBUEN	GO:0005216	ion channel activity	Losses
GBUEN	GO:0022838	substrate-specific channel activity	Losses
GBUEN	GO:0046873	metal ion transmembrane transporter activity	Losses
GBUEN	GO:0015081	sodium ion transmembrane transporter activity	Losses
GBUEN	GO:0022803	passive transmembrane transporter activity	Losses
GBUEN	GO:0015267	channel activity	Losses
GBUEN	GO:0016787	hydrolase activity	Losses
GBUEN	GO:0001653	peptide receptor activity	Losses
GBUEN	GO:0004500	dopamine beta-monooxygenase activity	Losses
GBUEN	GO:0030594	neurotransmitter receptor activity	Losses
GBUEN	GO:0008081	phosphoric diester hydrolase activity	Losses
GBUEN	GO:0005230	extracellular ligand-gated ion channel activity	Losses
GBUEN	GO:0019783	ubiquitin-like protein-specific protease activity	Losses
GBUEN	GO:0005272	sodium channel activity	Losses
GBUEN	GO:0016788	hydrolase activity, acting on ester bonds	Losses
GBUEN	GO:0008188	neuropeptide receptor activity	Losses
GBUEN	GO:0004713	protein tyrosine kinase activity	Losses
GBUEN	GO:0004383	guanylate cyclase activity	Losses
GBUEN	GO:0008233	peptidase activity	Losses
GBUEN	GO:0019001	guanyl nucleotide binding	Losses
GBUEN	GO:0009975	cyclase activity	Losses
GBUEN	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	Losses
GBUEN	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Losses
GBUEN	GO:0003951	NAD+ kinase activity	Losses
GBUEN	GO:0004622	lysophospholipase activity	Losses
GBUEN	GO:0016849	phosphorus-oxygen lyase activity	Losses
GBUEN	GO:0004620	phospholipase activity	Losses
GBUEN	GO:0008528	G-protein coupled peptide receptor activity	Losses
GBUEN	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
GBUEN	GO:0101005	ubiquitinyl hydrolase activity	Extinctions
GBUEN	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Extinctions
GBUEN	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Extinctions
GBUEN	GO:0004888	transmembrane signaling receptor activity	Extinctions
GBUEN	GO:0008066	glutamate receptor activity	Extinctions
GBUEN	GO:0019783	ubiquitin-like protein-specific protease activity	Extinctions
GBUEN	GO:0099600	transmembrane receptor activity	Extinctions
GBUEN	GO:0008484	sulfuric ester hydrolase activity	Extinctions
GBUEN	GO:0009975	cyclase activity	Extinctions
GBUEN	GO:0004383	guanylate cyclase activity	Extinctions
GBUEN	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
GBUEN	GO:0038023	signaling receptor activity	Extinctions
GBUEN	GO:0004970	ionotropic glutamate receptor activity	Extinctions
GBUEN	GO:0022824	transmitter-gated ion channel activity	Extinctions
GBUEN	GO:0022835	transmitter-gated channel activity	Extinctions
GBUEN	GO:0004871	signal transducer activity	Extinctions
GBUEN	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
GBUEN	GO:0016298	lipase activity	Extinctions
GBUEN	GO:0005216	ion channel activity	Extinctions
GBUEN	GO:0004622	lysophospholipase activity	Extinctions
GBUEN	GO:0022838	substrate-specific channel activity	Extinctions
GBUEN	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
GBUEN	GO:0004930	G-protein coupled receptor activity	Extinctions
GBUEN	GO:0022803	passive transmembrane transporter activity	Extinctions
GBUEN	GO:0015267	channel activity	Extinctions
GBUEN	GO:0016229	steroid dehydrogenase activity	Extinctions
GBUEN	GO:0032182	ubiquitin-like protein binding	Extinctions
GBUEN	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	Extinctions
GBUEN	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Extinctions
GBUEN	GO:0005261	cation channel activity	Extinctions
GBUEN	GO:0008469	histone-arginine N-methyltransferase activity	Extinctions
GBUEN	GO:0008430	selenium binding	Extinctions
GBUEN	GO:0004303	estradiol 17-beta-dehydrogenase activity	Extinctions
GBUEN	GO:0016273	arginine N-methyltransferase activity	Extinctions
GBUEN	GO:0016274	protein-arginine N-methyltransferase activity	Extinctions
GBUEN	GO:0004872	receptor activity	Extinctions
GBUEN	GO:0030594	neurotransmitter receptor activity	Extinctions
GBUEN	GO:0046873	metal ion transmembrane transporter activity	Extinctions
AALBI	GO:0004872	receptor activity	Gains
AALBI	GO:0060089	molecular transducer activity	Gains
AALBI	GO:0099600	transmembrane receptor activity	Gains
AALBI	GO:0015464	acetylcholine receptor activity	Gains
AALBI	GO:0099528	G-protein coupled neurotransmitter receptor activity	Gains
AALBI	GO:0016907	G-protein coupled acetylcholine receptor activity	Gains
AALBI	GO:0003964	RNA-directed DNA polymerase activity	Gains
AALBI	GO:0038023	signaling receptor activity	Gains
AALBI	GO:0004871	signal transducer activity	Gains
AALBI	GO:0008227	G-protein coupled amine receptor activity	Gains
AALBI	GO:0004888	transmembrane signaling receptor activity	Gains
AALBI	GO:0003796	lysozyme activity	Gains
AALBI	GO:0003700	DNA binding transcription factor activity	Gains
AALBI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
AALBI	GO:0140110	transcription regulator activity	Gains
AALBI	GO:0004143	diacylglycerol kinase activity	Gains
AALBI	GO:0034061	DNA polymerase activity	Gains
AALBI	GO:0003951	NAD+ kinase activity	Gains
AALBI	GO:0140103	catalytic activity, acting on a glycoprotein	Gains
AALBI	GO:0008835	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	Gains
AALBI	GO:0008836	diaminopimelate decarboxylase activity	Gains
AALBI	GO:0071837	HMG box domain binding	Gains
AALBI	GO:0001106	RNA polymerase II transcription corepressor activity	Gains
AALBI	GO:0004791	thioredoxin-disulfide reductase activity	Gains
AALBI	GO:0004586	ornithine decarboxylase activity	Gains
AALBI	GO:0001587	Gq/11-coupled serotonin receptor activity	Gains
AALBI	GO:0003945	N-acetyllactosamine synthase activity	Gains
AALBI	GO:0060072	large conductance calcium-activated potassium channel activity	Gains
AALBI	GO:0071906	CRD domain binding	Gains
AALBI	GO:0017151	DEAD/H-box RNA helicase binding	Gains
AALBI	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Gains
AALBI	GO:0046976	histone methyltransferase activity (H3-K27 specific)	Gains
AALBI	GO:0004362	glutathione-disulfide reductase activity	Gains
AALBI	GO:0004930	G-protein coupled receptor activity	Gains
AALBI	GO:0061783	peptidoglycan muralytic activity	Gains
AALBI	GO:0008233	peptidase activity	Gains
AALBI	GO:0008568	microtubule-severing ATPase activity	Gains
AALBI	GO:0008890	glycine C-acetyltransferase activity	Gains
AALBI	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	Gains
AALBI	GO:0017034	Rap guanyl-nucleotide exchange factor activity	Gains
AALBI	GO:0004555	alpha,alpha-trehalase activity	Gains
AALBI	GO:0004666	prostaglandin-endoperoxide synthase activity	Gains
AALBI	GO:0015037	peptide disulfide oxidoreductase activity	Gains
AALBI	GO:0015038	glutathione disulfide oxidoreductase activity	Gains
AALBI	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
AALBI	GO:0015927	trehalase activity	Gains
AALBI	GO:0030594	neurotransmitter receptor activity	Gains
AALBI	GO:0005200	structural constituent of cytoskeleton	Losses
AALBI	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
AALBI	GO:0042834	peptidoglycan binding	Losses
AALBI	GO:0046914	transition metal ion binding	Losses
AALBI	GO:0008270	zinc ion binding	Losses
AALBI	GO:0008173	RNA methyltransferase activity	Losses
AALBI	GO:0001530	lipopolysaccharide binding	Losses
AALBI	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
AALBI	GO:0008527	taste receptor activity	Losses
AALBI	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Losses
AALBI	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
AALBI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
AALBI	GO:0004364	glutathione transferase activity	Losses
AALBI	GO:0005198	structural molecule activity	Losses
AALBI	GO:0050591	quinine 3-monooxygenase activity	Losses
AALBI	GO:0008889	glycerophosphodiester phosphodiesterase activity	Losses
AALBI	GO:0018685	alkane 1-monooxygenase activity	Losses
AALBI	GO:0016848	carbon-halide lyase activity	Losses
AALBI	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
AALBI	GO:0004370	glycerol kinase activity	Losses
AALBI	GO:0008168	methyltransferase activity	Losses
AALBI	GO:0005539	glycosaminoglycan binding	Losses
AALBI	GO:0004303	estradiol 17-beta-dehydrogenase activity	Losses
AALBI	GO:0016229	steroid dehydrogenase activity	Losses
AALBI	GO:0016741	transferase activity, transferring one-carbon groups	Losses
AALBI	GO:0005506	iron ion binding	Losses
AALBI	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Losses
AALBI	GO:0004708	MAP kinase kinase activity	Losses
AALBI	GO:0070891	lipoteichoic acid binding	Losses
AALBI	GO:0030882	lipid antigen binding	Losses
AALBI	GO:0046592	polyamine oxidase activity	Losses
AALBI	GO:0038187	pattern recognition receptor activity	Losses
AALBI	GO:0008329	signaling pattern recognition receptor activity	Losses
AALBI	GO:0008174	mRNA methyltransferase activity	Losses
AALBI	GO:0016491	oxidoreductase activity	Losses
AALBI	GO:0004497	monooxygenase activity	Losses
AALBI	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
AALBI	GO:0008649	rRNA methyltransferase activity	Losses
AALBI	GO:0030247	polysaccharide binding	Losses
AALBI	GO:0001871	pattern binding	Losses
AALBI	GO:0140102	catalytic activity, acting on a rRNA	Losses
AALBI	GO:0004312	fatty acid synthase activity	Losses
AALBI	GO:0004197	cysteine-type endopeptidase activity	Losses
AALBI	GO:0008135	translation factor activity, RNA binding	Losses
AALBI	GO:0004629	phospholipase C activity	Losses
AALBI	GO:0003823	antigen binding	Losses
AALBI	GO:0031624	ubiquitin conjugating enzyme binding	Losses
AALBI	GO:0016423	tRNA (guanine) methyltransferase activity	Losses
AALBI	GO:0044390	ubiquitin-like protein conjugating enzyme binding	Losses
AALBI	GO:0003924	GTPase activity	Losses
AALBI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
AALBI	GO:0070330	aromatase activity	Losses
AALBI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
AALBI	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
AALBI	GO:0016417	S-acyltransferase activity	Losses
AALBI	GO:0005200	structural constituent of cytoskeleton	Extinctions
AALBI	GO:0008270	zinc ion binding	Extinctions
AALBI	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Extinctions
AALBI	GO:0008173	RNA methyltransferase activity	Extinctions
AALBI	GO:0046914	transition metal ion binding	Extinctions
AALBI	GO:0008168	methyltransferase activity	Extinctions
AALBI	GO:0016741	transferase activity, transferring one-carbon groups	Extinctions
AALBI	GO:0004708	MAP kinase kinase activity	Extinctions
AALBI	GO:0008174	mRNA methyltransferase activity	Extinctions
AALBI	GO:0005198	structural molecule activity	Extinctions
AALBI	GO:0016417	S-acyltransferase activity	Extinctions
AALBI	GO:0016423	tRNA (guanine) methyltransferase activity	Extinctions
AALBI	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Extinctions
AALBI	GO:0016229	steroid dehydrogenase activity	Extinctions
AALBI	GO:0003723	RNA binding	Extinctions
AALBI	GO:0070567	cytidylyltransferase activity	Extinctions
AALBI	GO:0003924	GTPase activity	Extinctions
AALBI	GO:0019706	protein-cysteine S-palmitoyltransferase activity	Extinctions
AALBI	GO:0019707	protein-cysteine S-acyltransferase activity	Extinctions
AALBI	GO:0016836	hydro-lyase activity	Extinctions
AALBI	GO:0004303	estradiol 17-beta-dehydrogenase activity	Extinctions
AALBI	GO:0140030	modification-dependent protein binding	Extinctions
AALBI	GO:0140034	methylation-dependent protein binding	Extinctions
AALBI	GO:0035064	methylated histone binding	Extinctions
AALBI	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly	Extinctions
AALBI	GO:0001132	RNA polymerase II transcription factor activity, TBP-class protein binding	Extinctions
AALBI	GO:0001083	transcription factor activity, RNA polymerase II basal transcription factor binding	Extinctions
SMIMO	GO:0003676	nucleic acid binding	Gains
SMIMO	GO:0016779	nucleotidyltransferase activity	Gains
SMIMO	GO:0003677	DNA binding	Gains
SMIMO	GO:0004831	tyrosine-tRNA ligase activity	Gains
SMIMO	GO:0019825	oxygen binding	Gains
SMIMO	GO:0005506	iron ion binding	Gains
SMIMO	GO:0034061	DNA polymerase activity	Gains
SMIMO	GO:0034062	5'-3' RNA polymerase activity	Gains
SMIMO	GO:0097747	RNA polymerase activity	Gains
SMIMO	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
SMIMO	GO:1901363	heterocyclic compound binding	Gains
SMIMO	GO:0097159	organic cyclic compound binding	Gains
SMIMO	GO:0032135	DNA insertion or deletion binding	Gains
SMIMO	GO:0032137	guanine/thymine mispair binding	Gains
SMIMO	GO:0032138	single base insertion or deletion binding	Gains
SMIMO	GO:0017025	TBP-class protein binding	Gains
SMIMO	GO:0003913	DNA photolyase activity	Gains
SMIMO	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Gains
SMIMO	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Gains
SMIMO	GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Gains
SMIMO	GO:0030971	receptor tyrosine kinase binding	Gains
SMIMO	GO:0009882	blue light photoreceptor activity	Gains
SMIMO	GO:1990782	protein tyrosine kinase binding	Gains
SMIMO	GO:0004820	glycine-tRNA ligase activity	Gains
SMIMO	GO:0008013	beta-catenin binding	Gains
SMIMO	GO:0008158	hedgehog receptor activity	Gains
SMIMO	GO:0071855	neuropeptide receptor binding	Gains
SMIMO	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
SMIMO	GO:0030983	mismatched DNA binding	Gains
SMIMO	GO:0016746	transferase activity, transferring acyl groups	Gains
SMIMO	GO:0004803	transposase activity	Gains
SMIMO	GO:0008395	steroid hydroxylase activity	Gains
SMIMO	GO:0140097	catalytic activity, acting on DNA	Gains
SMIMO	GO:0003964	RNA-directed DNA polymerase activity	Gains
SMIMO	GO:0003697	single-stranded DNA binding	Gains
SMIMO	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
SMIMO	GO:0004402	histone acetyltransferase activity	Gains
SMIMO	GO:0005262	calcium channel activity	Gains
SMIMO	GO:0061733	peptide-lysine-N-acetyltransferase activity	Gains
SMIMO	GO:0009022	tRNA nucleotidyltransferase activity	Gains
SMIMO	GO:0004686	elongation factor-2 kinase activity	Gains
SMIMO	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Gains
SMIMO	GO:0004363	glutathione synthase activity	Gains
SMIMO	GO:0043015	gamma-tubulin binding	Gains
SMIMO	GO:0008889	glycerophosphodiester phosphodiesterase activity	Gains
SMIMO	GO:0000400	four-way junction DNA binding	Gains
SMIMO	GO:0003887	DNA-directed DNA polymerase activity	Gains
SMIMO	GO:0001871	pattern binding	Gains
SMIMO	GO:0009881	photoreceptor activity	Gains
SMIMO	GO:0005245	voltage-gated calcium channel activity	Gains
SMIMO	GO:0030291	protein serine/threonine kinase inhibitor activity	Gains
SMIMO	GO:0030247	polysaccharide binding	Gains
SMIMO	GO:0003700	DNA binding transcription factor activity	Losses
SMIMO	GO:0140110	transcription regulator activity	Losses
SMIMO	GO:0004871	signal transducer activity	Losses
SMIMO	GO:0099600	transmembrane receptor activity	Losses
SMIMO	GO:0043565	sequence-specific DNA binding	Losses
SMIMO	GO:0004888	transmembrane signaling receptor activity	Losses
SMIMO	GO:0060089	molecular transducer activity	Losses
SMIMO	GO:0038023	signaling receptor activity	Losses
SMIMO	GO:0003964	RNA-directed DNA polymerase activity	Losses
SMIMO	GO:0004872	receptor activity	Losses
SMIMO	GO:0004930	G-protein coupled receptor activity	Losses
SMIMO	GO:1990837	sequence-specific double-stranded DNA binding	Losses
SMIMO	GO:0034061	DNA polymerase activity	Losses
SMIMO	GO:0008188	neuropeptide receptor activity	Losses
SMIMO	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
SMIMO	GO:0016500	protein-hormone receptor activity	Losses
SMIMO	GO:0003690	double-stranded DNA binding	Losses
SMIMO	GO:0030594	neurotransmitter receptor activity	Losses
SMIMO	GO:0050254	rhodopsin kinase activity	Losses
SMIMO	GO:0003677	DNA binding	Losses
SMIMO	GO:0008528	G-protein coupled peptide receptor activity	Losses
SMIMO	GO:0001653	peptide receptor activity	Losses
SMIMO	GO:0005267	potassium channel activity	Losses
SMIMO	GO:0044212	transcription regulatory region DNA binding	Losses
SMIMO	GO:0001067	regulatory region nucleic acid binding	Losses
SMIMO	GO:0000975	regulatory region DNA binding	Losses
SMIMO	GO:0015079	potassium ion transmembrane transporter activity	Losses
SMIMO	GO:0046873	metal ion transmembrane transporter activity	Losses
SMIMO	GO:0005509	calcium ion binding	Losses
SMIMO	GO:0099528	G-protein coupled neurotransmitter receptor activity	Losses
SMIMO	GO:0015464	acetylcholine receptor activity	Losses
SMIMO	GO:0016907	G-protein coupled acetylcholine receptor activity	Losses
SMIMO	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
SMIMO	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
SMIMO	GO:0004983	neuropeptide Y receptor activity	Losses
SMIMO	GO:0005261	cation channel activity	Losses
SMIMO	GO:0070001	aspartic-type peptidase activity	Losses
SMIMO	GO:0004190	aspartic-type endopeptidase activity	Losses
SMIMO	GO:0016779	nucleotidyltransferase activity	Losses
SMIMO	GO:0022836	gated channel activity	Losses
SMIMO	GO:0004672	protein kinase activity	Losses
SMIMO	GO:0003676	nucleic acid binding	Losses
SMIMO	GO:0140097	catalytic activity, acting on DNA	Losses
SMIMO	GO:0019894	kinesin binding	Losses
SMIMO	GO:0015116	sulfate transmembrane transporter activity	Losses
SMIMO	GO:0004000	adenosine deaminase activity	Losses
SMIMO	GO:0070491	repressing transcription factor binding	Losses
SMIMO	GO:0005216	ion channel activity	Losses
SMIMO	GO:0022838	substrate-specific channel activity	Losses
SMIMO	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
SMIMO	GO:0022892	substrate-specific transporter activity	Losses
SMIMO	GO:0042562	hormone binding	Losses
SMIMO	GO:0022803	passive transmembrane transporter activity	Losses
SMIMO	GO:0015267	channel activity	Losses
SMIMO	GO:0015075	ion transmembrane transporter activity	Losses
SMIMO	GO:0008227	G-protein coupled amine receptor activity	Losses
SMIMO	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
SMIMO	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Losses
SMIMO	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Losses
SMIMO	GO:0019198	transmembrane receptor protein phosphatase activity	Losses
SMIMO	GO:0033549	MAP kinase phosphatase activity	Losses
SMIMO	GO:0016301	kinase activity	Losses
SMIMO	GO:0022890	inorganic cation transmembrane transporter activity	Losses
SMIMO	GO:0008324	cation transmembrane transporter activity	Losses
SMIMO	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
SMIMO	GO:0022832	voltage-gated channel activity	Losses
SMIMO	GO:0005244	voltage-gated ion channel activity	Losses
SMIMO	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
SMIMO	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
SMIMO	GO:0015085	calcium ion transmembrane transporter activity	Losses
SMIMO	GO:0015103	inorganic anion transmembrane transporter activity	Losses
SMIMO	GO:0022857	transmembrane transporter activity	Losses
SMIMO	GO:0005092	GDP-dissociation inhibitor activity	Losses
SMIMO	GO:0004952	dopamine neurotransmitter receptor activity	Losses
SMIMO	GO:0019239	deaminase activity	Losses
SMIMO	GO:0022891	substrate-specific transmembrane transporter activity	Losses
SMIMO	GO:0022843	voltage-gated cation channel activity	Losses
SMIMO	GO:0004022	alcohol dehydrogenase (NAD) activity	Losses
SMIMO	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Losses
SMIMO	GO:0003989	acetyl-CoA carboxylase activity	Losses
SMIMO	GO:1901682	sulfur compound transmembrane transporter activity	Losses
SMIMO	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
SMIMO	GO:0070330	aromatase activity	Losses
SMIMO	GO:0005217	intracellular ligand-gated ion channel activity	Losses
SMIMO	GO:0030414	peptidase inhibitor activity	Losses
SMIMO	GO:0001104	RNA polymerase II transcription cofactor activity	Losses
SMIMO	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
SMIMO	GO:0005488	binding	Losses
SMIMO	GO:0018833	DDT-dehydrochlorinase activity	Losses
SMIMO	GO:0044017	histone acetyltransferase activity (H3-K27 specific)	Losses
SMIMO	GO:0016499	orexin receptor activity	Losses
SMIMO	GO:0010461	light-activated ion channel activity	Losses
SMIMO	GO:0050111	mycocerosate synthase activity	Losses
SMIMO	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
SMIMO	GO:0003911	DNA ligase (NAD+) activity	Losses
SMIMO	GO:0003912	DNA nucleotidylexotransferase activity	Losses
SMIMO	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
SMIMO	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
SMIMO	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
SMIMO	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
SMIMO	GO:0008046	axon guidance receptor activity	Losses
SMIMO	GO:0004689	phosphorylase kinase activity	Losses
SMIMO	GO:0004677	DNA-dependent protein kinase activity	Losses
SMIMO	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
SMIMO	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
SMIMO	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
SMIMO	GO:0051538	3 iron, 4 sulfur cluster binding	Losses
SMIMO	GO:0050840	extracellular matrix binding	Losses
SMIMO	GO:0016833	oxo-acid-lyase activity	Losses
SMIMO	GO:0042071	leucokinin receptor activity	Losses
SMIMO	GO:0008459	chondroitin 6-sulfotransferase activity	Losses
SMIMO	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
SMIMO	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
SMIMO	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
SMIMO	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
SMIMO	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
SMIMO	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
SMIMO	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
SMIMO	GO:0035237	corazonin receptor activity	Losses
SMIMO	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
SMIMO	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
SMIMO	GO:0003872	6-phosphofructokinase activity	Losses
SMIMO	GO:0005219	ryanodine-sensitive calcium-release channel activity	Losses
SMIMO	GO:0015499	formate transmembrane transporter activity	Losses
SMIMO	GO:0043993	histone acetyltransferase activity (H3-K18 specific)	Losses
SMIMO	GO:0036400	short neuropeptide F receptor activity	Losses
SMIMO	GO:0008815	citrate (pro-3S)-lyase activity	Losses
SMIMO	GO:0008816	citryl-CoA lyase activity	Losses
SMIMO	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
SMIMO	GO:0008579	JUN kinase phosphatase activity	Losses
SMIMO	GO:0015106	bicarbonate transmembrane transporter activity	Losses
SMIMO	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
SMIMO	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	Losses
SMIMO	GO:0019531	oxalate transmembrane transporter activity	Losses
SMIMO	GO:0003700	DNA binding transcription factor activity	Extinctions
SMIMO	GO:0004930	G-protein coupled receptor activity	Extinctions
SMIMO	GO:0030594	neurotransmitter receptor activity	Extinctions
SMIMO	GO:0140110	transcription regulator activity	Extinctions
SMIMO	GO:0043565	sequence-specific DNA binding	Extinctions
SMIMO	GO:0099528	G-protein coupled neurotransmitter receptor activity	Extinctions
SMIMO	GO:0015464	acetylcholine receptor activity	Extinctions
SMIMO	GO:0016907	G-protein coupled acetylcholine receptor activity	Extinctions
SMIMO	GO:0099600	transmembrane receptor activity	Extinctions
SMIMO	GO:0004888	transmembrane signaling receptor activity	Extinctions
SMIMO	GO:0003677	DNA binding	Extinctions
SMIMO	GO:0004871	signal transducer activity	Extinctions
SMIMO	GO:0008227	G-protein coupled amine receptor activity	Extinctions
SMIMO	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
SMIMO	GO:0003690	double-stranded DNA binding	Extinctions
SMIMO	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
SMIMO	GO:0038023	signaling receptor activity	Extinctions
SMIMO	GO:0044212	transcription regulatory region DNA binding	Extinctions
SMIMO	GO:0001067	regulatory region nucleic acid binding	Extinctions
SMIMO	GO:0000975	regulatory region DNA binding	Extinctions
SMIMO	GO:0004872	receptor activity	Extinctions
SMIMO	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Extinctions
SMIMO	GO:0004952	dopamine neurotransmitter receptor activity	Extinctions
SMIMO	GO:0060089	molecular transducer activity	Extinctions
SMIMO	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Extinctions
SMIMO	GO:0070330	aromatase activity	Extinctions
SMIMO	GO:0003676	nucleic acid binding	Extinctions
SMIMO	GO:0003912	DNA nucleotidylexotransferase activity	Extinctions
SMIMO	GO:0016833	oxo-acid-lyase activity	Extinctions
SMIMO	GO:0042071	leucokinin receptor activity	Extinctions
SMIMO	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
SMIMO	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
SMIMO	GO:0008816	citryl-CoA lyase activity	Extinctions
SMIMO	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	Extinctions
SMIMO	GO:0004713	protein tyrosine kinase activity	Extinctions
SMIMO	GO:0008188	neuropeptide receptor activity	Extinctions
SMIMO	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Extinctions
SMIMO	GO:0004983	neuropeptide Y receptor activity	Extinctions
SMIMO	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
SMIMO	GO:0030546	receptor activator activity	Extinctions
SMIMO	GO:0005094	Rho GDP-dissociation inhibitor activity	Extinctions
SMIMO	GO:0001637	G-protein coupled chemoattractant receptor activity	Extinctions
SMIMO	GO:0050591	quinine 3-monooxygenase activity	Extinctions
SMIMO	GO:0004950	chemokine receptor activity	Extinctions
SMIMO	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
SMIMO	GO:0052869	arachidonic acid omega-hydroxylase activity	Extinctions
SMIMO	GO:0052870	tocopherol omega-hydroxylase activity	Extinctions
SMIMO	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Extinctions
SMIMO	GO:0035100	ecdysone binding	Extinctions
SMIMO	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Extinctions
SMIMO	GO:0050051	leukotriene-B4 20-monooxygenase activity	Extinctions
SMIMO	GO:0004415	hyalurononglucosaminidase activity	Extinctions
SMIMO	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
SMIMO	GO:0001653	peptide receptor activity	Extinctions
SMIMO	GO:0070491	repressing transcription factor binding	Extinctions
CO1	GO:0003964	RNA-directed DNA polymerase activity	Gains
CO1	GO:0034061	DNA polymerase activity	Gains
CO1	GO:0016779	nucleotidyltransferase activity	Gains
CO1	GO:0003676	nucleic acid binding	Gains
CO1	GO:0140097	catalytic activity, acting on DNA	Gains
CO1	GO:0004190	aspartic-type endopeptidase activity	Gains
CO1	GO:0070001	aspartic-type peptidase activity	Gains
CO1	GO:0097159	organic cyclic compound binding	Gains
CO1	GO:1901363	heterocyclic compound binding	Gains
CO1	GO:0003677	DNA binding	Gains
CO1	GO:0008270	zinc ion binding	Gains
CO1	GO:0046914	transition metal ion binding	Gains
CO1	GO:0097747	RNA polymerase activity	Gains
CO1	GO:0034062	5'-3' RNA polymerase activity	Gains
CO1	GO:0004518	nuclease activity	Gains
CO1	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
CO1	GO:0046872	metal ion binding	Gains
CO1	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
CO1	GO:0043169	cation binding	Gains
CO1	GO:0005488	binding	Gains
CO1	GO:0004175	endopeptidase activity	Gains
CO1	GO:0004519	endonuclease activity	Gains
CO1	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
CO1	GO:0008233	peptidase activity	Gains
CO1	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
CO1	GO:0003723	RNA binding	Gains
CO1	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
CO1	GO:0004521	endoribonuclease activity	Gains
CO1	GO:0005212	structural constituent of eye lens	Gains
CO1	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Gains
CO1	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Gains
CO1	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
CO1	GO:0035586	purinergic receptor activity	Gains
CO1	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
CO1	GO:0003707	steroid hormone receptor activity	Gains
CO1	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
CO1	GO:0140098	catalytic activity, acting on RNA	Gains
CO1	GO:0004540	ribonuclease activity	Gains
CO1	GO:0004803	transposase activity	Gains
CO1	GO:0004871	signal transducer activity	Gains
CO1	GO:0005201	extracellular matrix structural constituent	Gains
CO1	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Gains
CO1	GO:0038023	signaling receptor activity	Gains
CO1	GO:0005214	structural constituent of chitin-based cuticle	Gains
CO1	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Gains
CO1	GO:0004075	biotin carboxylase activity	Gains
CO1	GO:0004013	adenosylhomocysteinase activity	Gains
CO1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
CO1	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Gains
CO1	GO:0016802	trialkylsulfonium hydrolase activity	Gains
CO1	GO:0003896	DNA primase activity	Gains
CO1	GO:0005501	retinoid binding	Gains
CO1	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
CO1	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
CO1	GO:0016788	hydrolase activity, acting on ester bonds	Gains
CO1	GO:0060089	molecular transducer activity	Gains
CO1	GO:0005267	potassium channel activity	Gains
CO1	GO:0015079	potassium ion transmembrane transporter activity	Gains
CO1	GO:0004872	receptor activity	Gains
CO1	GO:0016491	oxidoreductase activity	Losses
CO1	GO:0008527	taste receptor activity	Losses
CO1	GO:0004984	olfactory receptor activity	Losses
CO1	GO:0015929	hexosaminidase activity	Losses
CO1	GO:0046875	ephrin receptor binding	Losses
CO1	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
CO1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	Losses
CO1	GO:0004301	epoxide hydrolase activity	Losses
CO1	GO:0050112	inositol 2-dehydrogenase activity	Losses
CO1	GO:0002046	opsin binding	Losses
CO1	GO:0042925	benzoate transmembrane transporter activity	Losses
CO1	GO:0004566	beta-glucuronidase activity	Losses
CO1	GO:0004557	alpha-galactosidase activity	Losses
CO1	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
CO1	GO:0052870	tocopherol omega-hydroxylase activity	Losses
CO1	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
CO1	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
CO1	GO:0016499	orexin receptor activity	Losses
CO1	GO:0008936	nicotinamidase activity	Losses
CO1	GO:0052692	raffinose alpha-galactosidase activity	Losses
CO1	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
CO1	GO:0004061	arylformamidase activity	Losses
CO1	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
CO1	GO:0098772	molecular function regulator	Losses
CO1	GO:0004620	phospholipase activity	Losses
CO1	GO:0015002	heme-copper terminal oxidase activity	Losses
CO1	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
CO1	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
CO1	GO:0004129	cytochrome-c oxidase activity	Losses
CO1	GO:0008384	IkappaB kinase activity	Losses
CO1	GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
CO1	GO:0031545	peptidyl-proline 4-dioxygenase activity	Losses
CO1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	Losses
CO1	GO:0008704	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	Losses
CO1	GO:0098518	polynucleotide phosphatase activity	Losses
CO1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	Losses
CO1	GO:0015459	potassium channel regulator activity	Losses
CO1	GO:0004799	thymidylate synthase activity	Losses
CO1	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
CO1	GO:0004656	procollagen-proline 4-dioxygenase activity	Losses
CO1	GO:0018800	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	Losses
CO1	GO:0018685	alkane 1-monooxygenase activity	Losses
CO1	GO:0043958	acryloyl-CoA reductase activity	Losses
CO1	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
CO1	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
CO1	GO:0099600	transmembrane receptor activity	Losses
CO1	GO:0005230	extracellular ligand-gated ion channel activity	Losses
CO1	GO:0005200	structural constituent of cytoskeleton	Losses
CO1	GO:0005549	odorant binding	Losses
CO1	GO:0016298	lipase activity	Losses
CO1	GO:0099106	ion channel regulator activity	Losses
CO1	GO:0019992	diacylglycerol binding	Losses
CO1	GO:0004484	mRNA guanylyltransferase activity	Losses
CO1	GO:0019798	procollagen-proline dioxygenase activity	Losses
CO1	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	Losses
CO1	GO:0015101	organic cation transmembrane transporter activity	Losses
CO1	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
CO1	GO:0022891	substrate-specific transmembrane transporter activity	Losses
CO1	GO:0042925	benzoate transmembrane transporter activity	Extinctions
CO1	GO:0005200	structural constituent of cytoskeleton	Extinctions
CO1	GO:0004197	cysteine-type endopeptidase activity	Extinctions
CO1	GO:0015459	potassium channel regulator activity	Extinctions
CO1	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Extinctions
CO1	GO:0099106	ion channel regulator activity	Extinctions
CO1	GO:0004144	diacylglycerol O-acyltransferase activity	Extinctions
CO1	GO:0009008	DNA-methyltransferase activity	Extinctions
CO1	GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
CO1	GO:0016215	acyl-CoA desaturase activity	Extinctions
CO1	GO:0004768	stearoyl-CoA 9-desaturase activity	Extinctions
CO1	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	Extinctions
CO1	GO:0008028	monocarboxylic acid transmembrane transporter activity	Extinctions
CO1	GO:0016433	rRNA (adenine) methyltransferase activity	Extinctions
CO3	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
CO3	GO:0060089	molecular transducer activity	Gains
CO3	GO:0004871	signal transducer activity	Gains
CO3	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
CO3	GO:0004872	receptor activity	Gains
CO3	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
CO3	GO:0030246	carbohydrate binding	Gains
CO3	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
CO3	GO:0038023	signaling receptor activity	Gains
CO3	GO:0016301	kinase activity	Gains
CO3	GO:0001872	(1->3)-beta-D-glucan binding	Gains
CO3	GO:0005534	galactose binding	Gains
CO3	GO:0004672	protein kinase activity	Gains
CO3	GO:0022843	voltage-gated cation channel activity	Gains
CO3	GO:0004692	cGMP-dependent protein kinase activity	Gains
CO3	GO:0015299	solute:proton antiporter activity	Gains
CO3	GO:0022836	gated channel activity	Gains
CO3	GO:0005509	calcium ion binding	Gains
CO3	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
CO3	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
CO3	GO:0043855	cyclic nucleotide-gated ion channel activity	Gains
CO3	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Gains
CO3	GO:0005328	neurotransmitter:sodium symporter activity	Gains
CO3	GO:0015291	secondary active transmembrane transporter activity	Gains
CO3	GO:0099600	transmembrane receptor activity	Gains
CO3	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
CO3	GO:0016917	GABA receptor activity	Gains
CO3	GO:0015298	solute:cation antiporter activity	Gains
CO3	GO:0016787	hydrolase activity	Gains
CO3	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
CO3	GO:0008329	signaling pattern recognition receptor activity	Gains
CO3	GO:0038187	pattern recognition receptor activity	Gains
CO3	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
CO3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	Gains
CO3	GO:0008519	ammonium transmembrane transporter activity	Gains
CO3	GO:0015385	sodium:proton antiporter activity	Gains
CO3	GO:0022832	voltage-gated channel activity	Gains
CO3	GO:0005244	voltage-gated ion channel activity	Gains
CO3	GO:0005216	ion channel activity	Gains
CO3	GO:0019842	vitamin binding	Gains
CO3	GO:0022838	substrate-specific channel activity	Gains
CO3	GO:0003951	NAD+ kinase activity	Gains
CO3	GO:0005326	neurotransmitter transporter activity	Gains
CO3	GO:0015926	glucosidase activity	Gains
CO3	GO:0048029	monosaccharide binding	Gains
CO3	GO:0015081	sodium ion transmembrane transporter activity	Gains
CO3	GO:0015267	channel activity	Gains
CO3	GO:0022803	passive transmembrane transporter activity	Gains
CO3	GO:0020037	heme binding	Gains
CO3	GO:0052689	carboxylic ester hydrolase activity	Gains
CO3	GO:0004691	cAMP-dependent protein kinase activity	Gains
CO3	GO:0004952	dopamine neurotransmitter receptor activity	Gains
CO3	GO:0005451	monovalent cation:proton antiporter activity	Gains
CO3	GO:0042043	neurexin family protein binding	Gains
CO3	GO:0042171	lysophosphatidic acid acyltransferase activity	Gains
CO3	GO:0046906	tetrapyrrole binding	Gains
CO3	GO:0004888	transmembrane signaling receptor activity	Gains
CO3	GO:0070279	vitamin B6 binding	Gains
CO3	GO:0030170	pyridoxal phosphate binding	Gains
CO3	GO:0005261	cation channel activity	Gains
CO3	GO:0015297	antiporter activity	Gains
CO3	GO:0008324	cation transmembrane transporter activity	Gains
CO3	GO:0004930	G-protein coupled receptor activity	Gains
CO3	GO:0004935	adrenergic receptor activity	Gains
CO3	GO:0004385	guanylate kinase activity	Gains
CO3	GO:0015645	fatty acid ligase activity	Gains
CO3	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
CO3	GO:0008239	dipeptidyl-peptidase activity	Gains
CO3	GO:0005217	intracellular ligand-gated ion channel activity	Gains
CO3	GO:0000339	RNA cap binding	Gains
CO3	GO:0004383	guanylate cyclase activity	Gains
CO3	GO:0015075	ion transmembrane transporter activity	Gains
CO3	GO:0030594	neurotransmitter receptor activity	Gains
CO3	GO:0005549	odorant binding	Losses
CO3	GO:0004984	olfactory receptor activity	Losses
CO3	GO:0004888	transmembrane signaling receptor activity	Losses
CO3	GO:0004930	G-protein coupled receptor activity	Losses
CO3	GO:0099600	transmembrane receptor activity	Losses
CO3	GO:0038023	signaling receptor activity	Losses
CO3	GO:0004872	receptor activity	Losses
CO3	GO:0003964	RNA-directed DNA polymerase activity	Losses
CO3	GO:0060089	molecular transducer activity	Losses
CO3	GO:0034061	DNA polymerase activity	Losses
CO3	GO:0004871	signal transducer activity	Losses
CO3	GO:0048018	receptor ligand activity	Losses
CO3	GO:0030545	receptor regulator activity	Losses
CO3	GO:0016779	nucleotidyltransferase activity	Losses
CO3	GO:0008527	taste receptor activity	Losses
CO3	GO:0005184	neuropeptide hormone activity	Losses
CO3	GO:0140097	catalytic activity, acting on DNA	Losses
CO3	GO:0033041	sweet taste receptor activity	Losses
CO3	GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
CO3	GO:0005179	hormone activity	Losses
CO3	GO:0004175	endopeptidase activity	Losses
CO3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
CO3	GO:0071855	neuropeptide receptor binding	Losses
CO3	GO:0030955	potassium ion binding	Losses
CO3	GO:0031420	alkali metal ion binding	Losses
CO3	GO:0004743	pyruvate kinase activity	Losses
CO3	GO:0004497	monooxygenase activity	Losses
CO3	GO:0005102	receptor binding	Losses
CO3	GO:0004970	ionotropic glutamate receptor activity	Losses
CO3	GO:0022824	transmitter-gated ion channel activity	Losses
CO3	GO:0022835	transmitter-gated channel activity	Losses
CO3	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
CO3	GO:0042834	peptidoglycan binding	Losses
CO3	GO:0016615	malate dehydrogenase activity	Losses
CO3	GO:0004312	fatty acid synthase activity	Losses
CO3	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
CO3	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
CO3	GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
CO3	GO:0004602	glutathione peroxidase activity	Losses
CO3	GO:0070330	aromatase activity	Losses
CO3	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
CO3	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
CO3	GO:0008066	glutamate receptor activity	Losses
CO3	GO:0004252	serine-type endopeptidase activity	Losses
CO3	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity	Losses
CO3	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
CO3	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
CO3	GO:0008093	cytoskeletal adaptor activity	Losses
CO3	GO:0036263	L-DOPA monooxygenase activity	Losses
CO3	GO:0036264	dopamine monooxygenase activity	Losses
CO3	GO:0003905	alkylbase DNA N-glycosylase activity	Losses
CO3	GO:0004667	prostaglandin-D synthase activity	Losses
CO3	GO:0015438	teichoic-acid-transporting ATPase activity	Losses
CO3	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Losses
CO3	GO:0008031	eclosion hormone activity	Losses
CO3	GO:0033038	bitter taste receptor activity	Losses
CO3	GO:0015162	teichoic acid transmembrane transporter activity	Losses
CO3	GO:0050613	delta14-sterol reductase activity	Losses
CO3	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
CO3	GO:0015250	water channel activity	Losses
CO3	GO:0052870	tocopherol omega-hydroxylase activity	Losses
CO3	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
CO3	GO:0052821	DNA-7-methyladenine glycosylase activity	Losses
CO3	GO:0052822	DNA-3-methylguanine glycosylase activity	Losses
CO3	GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity	Losses
CO3	GO:0052841	inositol bisdiphosphate tetrakisphosphate diphosphatase activity	Losses
CO3	GO:0052842	inositol diphosphate pentakisphosphate diphosphatase activity	Losses
CO3	GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	Losses
CO3	GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity	Losses
CO3	GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	Losses
CO3	GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity	Losses
CO3	GO:0052847	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	Losses
CO3	GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	Losses
CO3	GO:0004097	catechol oxidase activity	Losses
CO3	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Losses
CO3	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
CO3	GO:0030586	[methionine synthase] reductase activity	Losses
CO3	GO:0047886	farnesol dehydrogenase activity	Losses
CO3	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
CO3	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
CO3	GO:0047598	7-dehydrocholesterol reductase activity	Losses
CO3	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity	Losses
CO3	GO:0005368	taurine transmembrane transporter activity	Losses
CO3	GO:0005369	taurine:sodium symporter activity	Losses
CO3	GO:0016160	amylase activity	Losses
CO3	GO:0005372	water transmembrane transporter activity	Losses
CO3	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
CO3	GO:0043733	DNA-3-methylbase glycosylase activity	Losses
CO3	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
CO3	GO:0004398	histidine decarboxylase activity	Losses
CO3	GO:0004321	fatty-acyl-CoA synthase activity	Losses
CO3	GO:0016207	4-coumarate-CoA ligase activity	Losses
CO3	GO:0016794	diphosphoric monoester hydrolase activity	Losses
CO3	GO:0004499	N,N-dimethylaniline monooxygenase activity	Losses
CO3	GO:0097005	adipokinetic hormone receptor binding	Losses
CO3	GO:0051428	peptide hormone receptor binding	Losses
CO3	GO:0008725	DNA-3-methyladenine glycosylase activity	Losses
CO3	GO:0008728	GTP diphosphokinase activity	Losses
CO3	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Losses
CO3	GO:0004100	chitin synthase activity	Losses
CO3	GO:0004108	citrate (Si)-synthase activity	Losses
CO3	GO:0017159	pantetheine hydrolase activity	Losses
CO3	GO:0015026	coreceptor activity	Losses
CO3	GO:0017128	phospholipid scramblase activity	Losses
CO3	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
CO3	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Losses
CO3	GO:0004735	pyrroline-5-carboxylate reductase activity	Losses
CO3	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
CO3	GO:0050797	thymidylate synthase (FAD) activity	Losses
CO3	GO:0004850	uridine phosphorylase activity	Losses
CO3	GO:0005521	lamin binding	Losses
CO3	GO:0043916	DNA-7-methylguanine glycosylase activity	Losses
CO3	GO:0036440	citrate synthase activity	Losses
CO3	GO:0019113	limonene monooxygenase activity	Losses
CO3	GO:0070976	TIR domain binding	Losses
CO3	GO:0004556	alpha-amylase activity	Losses
CO3	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Losses
CO3	GO:0004629	phospholipase C activity	Losses
CO3	GO:0004965	G-protein coupled GABA receptor activity	Losses
CO3	GO:0004364	glutathione transferase activity	Losses
CO3	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
CO3	GO:0004190	aspartic-type endopeptidase activity	Losses
CO3	GO:0070001	aspartic-type peptidase activity	Losses
CO3	GO:0004930	G-protein coupled receptor activity	Extinctions
CO3	GO:0004888	transmembrane signaling receptor activity	Extinctions
CO3	GO:0004984	olfactory receptor activity	Extinctions
CO3	GO:0099600	transmembrane receptor activity	Extinctions
CO3	GO:0038023	signaling receptor activity	Extinctions
CO3	GO:0005549	odorant binding	Extinctions
CO3	GO:0004872	receptor activity	Extinctions
CO3	GO:0060089	molecular transducer activity	Extinctions
CO3	GO:0004871	signal transducer activity	Extinctions
CO3	GO:0004970	ionotropic glutamate receptor activity	Extinctions
CO3	GO:0022824	transmitter-gated ion channel activity	Extinctions
CO3	GO:0022835	transmitter-gated channel activity	Extinctions
CO3	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
CO3	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
CO3	GO:0071855	neuropeptide receptor binding	Extinctions
CO3	GO:0008066	glutamate receptor activity	Extinctions
CO3	GO:0030594	neurotransmitter receptor activity	Extinctions
CO3	GO:0008527	taste receptor activity	Extinctions
CO3	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
CO3	GO:0003905	alkylbase DNA N-glycosylase activity	Extinctions
CO3	GO:0033038	bitter taste receptor activity	Extinctions
CO3	GO:0052821	DNA-7-methyladenine glycosylase activity	Extinctions
CO3	GO:0052822	DNA-3-methylguanine glycosylase activity	Extinctions
CO3	GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052841	inositol bisdiphosphate tetrakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052842	inositol diphosphate pentakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	Extinctions
CO3	GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity	Extinctions
CO3	GO:0052847	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	Extinctions
CO3	GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	Extinctions
CO3	GO:0030586	[methionine synthase] reductase activity	Extinctions
CO3	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity	Extinctions
CO3	GO:0005368	taurine transmembrane transporter activity	Extinctions
CO3	GO:0005369	taurine:sodium symporter activity	Extinctions
CO3	GO:0043733	DNA-3-methylbase glycosylase activity	Extinctions
CO3	GO:0016207	4-coumarate-CoA ligase activity	Extinctions
CO3	GO:0016794	diphosphoric monoester hydrolase activity	Extinctions
CO3	GO:0008725	DNA-3-methyladenine glycosylase activity	Extinctions
CO3	GO:0008728	GTP diphosphokinase activity	Extinctions
CO3	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Extinctions
CO3	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Extinctions
CO3	GO:0043916	DNA-7-methylguanine glycosylase activity	Extinctions
CO3	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Extinctions
CO3	GO:0004175	endopeptidase activity	Extinctions
CO3	GO:0048018	receptor ligand activity	Extinctions
CO3	GO:0042826	histone deacetylase binding	Extinctions
CO3	GO:0030545	receptor regulator activity	Extinctions
CO3	GO:0015276	ligand-gated ion channel activity	Extinctions
CO3	GO:0022834	ligand-gated channel activity	Extinctions
CO3	GO:0016084	myostimulatory hormone activity	Extinctions
CO3	GO:0015183	L-aspartate transmembrane transporter activity	Extinctions
CO3	GO:0001013	RNA polymerase I regulatory region DNA binding	Extinctions
CO3	GO:0015501	glutamate:sodium symporter activity	Extinctions
CO3	GO:0016248	channel inhibitor activity	Extinctions
CO3	GO:0004496	mevalonate kinase activity	Extinctions
CO3	GO:0008200	ion channel inhibitor activity	Extinctions
CO3	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
CO3	GO:0008897	holo-[acyl-carrier-protein] synthase activity	Extinctions
CO3	GO:0001163	RNA polymerase I regulatory region sequence-specific DNA binding	Extinctions
CO3	GO:0016531	copper chaperone activity	Extinctions
CO3	GO:0004751	ribose-5-phosphate isomerase activity	Extinctions
CO3	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Extinctions
CO3	GO:0048039	ubiquinone binding	Extinctions
CO5	GO:0005549	odorant binding	Gains
CO5	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
CO5	GO:0003964	RNA-directed DNA polymerase activity	Gains
CO5	GO:0004984	olfactory receptor activity	Gains
CO5	GO:0034061	DNA polymerase activity	Gains
CO5	GO:0004518	nuclease activity	Gains
CO5	GO:0005242	inward rectifier potassium channel activity	Gains
CO5	GO:0015276	ligand-gated ion channel activity	Gains
CO5	GO:0022834	ligand-gated channel activity	Gains
CO5	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
CO5	GO:0022857	transmembrane transporter activity	Gains
CO5	GO:0004521	endoribonuclease activity	Gains
CO5	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
CO5	GO:0050591	quinine 3-monooxygenase activity	Gains
CO5	GO:0004555	alpha,alpha-trehalase activity	Gains
CO5	GO:0015927	trehalase activity	Gains
CO5	GO:0140097	catalytic activity, acting on DNA	Gains
CO5	GO:0099094	ligand-gated cation channel activity	Gains
CO5	GO:0008527	taste receptor activity	Gains
CO5	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
CO5	GO:0005216	ion channel activity	Gains
CO5	GO:0022838	substrate-specific channel activity	Gains
CO5	GO:0016779	nucleotidyltransferase activity	Gains
CO5	GO:0005215	transporter activity	Gains
CO5	GO:0099600	transmembrane receptor activity	Gains
CO5	GO:0022803	passive transmembrane transporter activity	Gains
CO5	GO:0015267	channel activity	Gains
CO5	GO:0004540	ribonuclease activity	Gains
CO5	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
CO5	GO:0009055	electron transfer activity	Gains
CO5	GO:0022891	substrate-specific transmembrane transporter activity	Gains
CO5	GO:0004519	endonuclease activity	Gains
CO5	GO:0005249	voltage-gated potassium channel activity	Gains
CO5	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
CO5	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
CO5	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
CO5	GO:0004872	receptor activity	Gains
CO5	GO:0004527	exonuclease activity	Gains
CO5	GO:0005267	potassium channel activity	Gains
CO5	GO:0005261	cation channel activity	Gains
CO5	GO:0022836	gated channel activity	Gains
CO5	GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
CO5	GO:0015179	L-amino acid transmembrane transporter activity	Gains
CO5	GO:0005337	nucleoside transmembrane transporter activity	Gains
CO5	GO:0060089	molecular transducer activity	Gains
CO5	GO:0009982	pseudouridine synthase activity	Gains
CO5	GO:0015075	ion transmembrane transporter activity	Gains
CO5	GO:0070330	aromatase activity	Gains
CO5	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
CO5	GO:0003990	acetylcholinesterase activity	Gains
CO5	GO:0004602	glutathione peroxidase activity	Gains
CO5	GO:0004806	triglyceride lipase activity	Gains
CO5	GO:0022892	substrate-specific transporter activity	Gains
CO5	GO:0046914	transition metal ion binding	Gains
CO5	GO:0008324	cation transmembrane transporter activity	Gains
CO5	GO:0005506	iron ion binding	Gains
CO5	GO:0015280	ligand-gated sodium channel activity	Gains
CO5	GO:0004356	glutamate-ammonia ligase activity	Gains
CO5	GO:0004359	glutaminase activity	Gains
CO5	GO:0015222	serotonin transmembrane transporter activity	Gains
CO5	GO:0010314	phosphatidylinositol-5-phosphate binding	Gains
CO5	GO:0005436	sodium:phosphate symporter activity	Gains
CO5	GO:0004301	epoxide hydrolase activity	Gains
CO5	GO:0008251	tRNA-specific adenosine deaminase activity	Gains
CO5	GO:0050112	inositol 2-dehydrogenase activity	Gains
CO5	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
CO5	GO:0018833	DDT-dehydrochlorinase activity	Gains
CO5	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Gains
CO5	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Gains
CO5	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Gains
CO5	GO:0050291	sphingosine N-acyltransferase activity	Gains
CO5	GO:0005225	volume-sensitive anion channel activity	Gains
CO5	GO:0042943	D-amino acid transmembrane transporter activity	Gains
CO5	GO:0004791	thioredoxin-disulfide reductase activity	Gains
CO5	GO:0004796	thromboxane-A synthase activity	Gains
CO5	GO:0016211	ammonia ligase activity	Gains
CO5	GO:0045735	nutrient reservoir activity	Gains
CO5	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
CO5	GO:0070379	high mobility group box 1 binding	Gains
CO5	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Gains
CO5	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Gains
CO5	GO:0044736	acid-sensing ion channel activity	Gains
CO5	GO:0005550	pheromone binding	Gains
CO5	GO:0004566	beta-glucuronidase activity	Gains
CO5	GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	Gains
CO5	GO:0003919	FMN adenylyltransferase activity	Gains
CO5	GO:0004651	polynucleotide 5'-phosphatase activity	Gains
CO5	GO:0008084	imaginal disc growth factor receptor binding	Gains
CO5	GO:0072320	volume-sensitive chloride channel activity	Gains
CO5	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Gains
CO5	GO:0050093	methanol dehydrogenase activity	Gains
CO5	GO:0008936	nicotinamidase activity	Gains
CO5	GO:0070742	C2H2 zinc finger domain binding	Gains
CO5	GO:0036132	13-prostaglandin reductase activity	Gains
CO5	GO:0004061	arylformamidase activity	Gains
CO5	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
CO5	GO:0005329	dopamine transmembrane transporter activity	Gains
CO5	GO:0019811	cocaine binding	Gains
CO5	GO:0004362	glutathione-disulfide reductase activity	Gains
CO5	GO:0016209	antioxidant activity	Gains
CO5	GO:0022843	voltage-gated cation channel activity	Gains
CO5	GO:0016491	oxidoreductase activity	Gains
CO5	GO:0004104	cholinesterase activity	Gains
CO5	GO:0003964	RNA-directed DNA polymerase activity	Losses
CO5	GO:0034061	DNA polymerase activity	Losses
CO5	GO:0003676	nucleic acid binding	Losses
CO5	GO:0016779	nucleotidyltransferase activity	Losses
CO5	GO:0140097	catalytic activity, acting on DNA	Losses
CO5	GO:0004190	aspartic-type endopeptidase activity	Losses
CO5	GO:0070001	aspartic-type peptidase activity	Losses
CO5	GO:0003677	DNA binding	Losses
CO5	GO:1901363	heterocyclic compound binding	Losses
CO5	GO:0097159	organic cyclic compound binding	Losses
CO5	GO:0008270	zinc ion binding	Losses
CO5	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
CO5	GO:0008233	peptidase activity	Losses
CO5	GO:0046914	transition metal ion binding	Losses
CO5	GO:0004175	endopeptidase activity	Losses
CO5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
CO5	GO:0022890	inorganic cation transmembrane transporter activity	Losses
CO5	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
CO5	GO:0008324	cation transmembrane transporter activity	Losses
CO5	GO:0015079	potassium ion transmembrane transporter activity	Losses
CO5	GO:0005244	voltage-gated ion channel activity	Losses
CO5	GO:0022832	voltage-gated channel activity	Losses
CO5	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
CO5	GO:0005158	insulin receptor binding	Losses
CO5	GO:0005251	delayed rectifier potassium channel activity	Losses
CO5	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Losses
CO5	GO:0015075	ion transmembrane transporter activity	Losses
CO5	GO:0004518	nuclease activity	Losses
CO5	GO:0004129	cytochrome-c oxidase activity	Losses
CO5	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Losses
CO5	GO:0015002	heme-copper terminal oxidase activity	Losses
CO5	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
CO5	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
CO5	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
CO5	GO:0005488	binding	Losses
CO5	GO:0022857	transmembrane transporter activity	Losses
CO5	GO:0004736	pyruvate carboxylase activity	Losses
CO5	GO:0022821	potassium ion antiporter activity	Losses
CO5	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
CO5	GO:0005267	potassium channel activity	Losses
CO5	GO:0046872	metal ion binding	Losses
CO5	GO:0015291	secondary active transmembrane transporter activity	Losses
CO5	GO:0004519	endonuclease activity	Losses
CO5	GO:0043169	cation binding	Losses
CO5	GO:0022891	substrate-specific transmembrane transporter activity	Losses
CO5	GO:0005452	inorganic anion exchanger activity	Losses
CO5	GO:0008241	peptidyl-dipeptidase activity	Losses
CO5	GO:0022843	voltage-gated cation channel activity	Losses
CO5	GO:0005249	voltage-gated potassium channel activity	Losses
CO5	GO:0022804	active transmembrane transporter activity	Losses
CO5	GO:0070279	vitamin B6 binding	Losses
CO5	GO:0030170	pyridoxal phosphate binding	Losses
CO5	GO:0034062	5'-3' RNA polymerase activity	Losses
CO5	GO:0097747	RNA polymerase activity	Losses
CO5	GO:0003707	steroid hormone receptor activity	Losses
CO5	GO:0003676	nucleic acid binding	Extinctions
CO5	GO:0034061	DNA polymerase activity	Extinctions
CO5	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
CO5	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
CO5	GO:0016779	nucleotidyltransferase activity	Extinctions
CO5	GO:0003677	DNA binding	Extinctions
CO5	GO:1901363	heterocyclic compound binding	Extinctions
CO5	GO:0097159	organic cyclic compound binding	Extinctions
CO5	GO:0005452	inorganic anion exchanger activity	Extinctions
CO5	GO:0140097	catalytic activity, acting on DNA	Extinctions
CO5	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	Extinctions
CO5	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
CO5	GO:0005159	insulin-like growth factor receptor binding	Extinctions
CO5	GO:0018580	nitronate monooxygenase activity	Extinctions
CO5	GO:0004846	urate oxidase activity	Extinctions
CO5	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
CO5	GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	Extinctions
CO5	GO:0050353	trimethyllysine dioxygenase activity	Extinctions
CO5	GO:0015291	secondary active transmembrane transporter activity	Extinctions
CO7	GO:0005549	odorant binding	Gains
CO7	GO:0004984	olfactory receptor activity	Gains
CO7	GO:0004888	transmembrane signaling receptor activity	Gains
CO7	GO:0099600	transmembrane receptor activity	Gains
CO7	GO:0038023	signaling receptor activity	Gains
CO7	GO:0004930	G-protein coupled receptor activity	Gains
CO7	GO:0004871	signal transducer activity	Gains
CO7	GO:0004872	receptor activity	Gains
CO7	GO:0060089	molecular transducer activity	Gains
CO7	GO:0008527	taste receptor activity	Gains
CO7	GO:0003964	RNA-directed DNA polymerase activity	Gains
CO7	GO:0034061	DNA polymerase activity	Gains
CO7	GO:0004312	fatty acid synthase activity	Gains
CO7	GO:0016779	nucleotidyltransferase activity	Gains
CO7	GO:0015927	trehalase activity	Gains
CO7	GO:0004555	alpha,alpha-trehalase activity	Gains
CO7	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
CO7	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
CO7	GO:0018685	alkane 1-monooxygenase activity	Gains
CO7	GO:0016405	CoA-ligase activity	Gains
CO7	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
CO7	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
CO7	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
CO7	GO:0005215	transporter activity	Gains
CO7	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Gains
CO7	GO:0016491	oxidoreductase activity	Gains
CO7	GO:0003990	acetylcholinesterase activity	Gains
CO7	GO:0004568	chitinase activity	Gains
CO7	GO:0004983	neuropeptide Y receptor activity	Gains
CO7	GO:0016878	acid-thiol ligase activity	Gains
CO7	GO:0022857	transmembrane transporter activity	Gains
CO7	GO:0019238	cyclohydrolase activity	Gains
CO7	GO:0033041	sweet taste receptor activity	Gains
CO7	GO:0030246	carbohydrate binding	Gains
CO7	GO:0004364	glutathione transferase activity	Gains
CO7	GO:0004104	cholinesterase activity	Gains
CO7	GO:0008188	neuropeptide receptor activity	Gains
CO7	GO:0140097	catalytic activity, acting on DNA	Gains
CO7	GO:0004252	serine-type endopeptidase activity	Gains
CO7	GO:0004970	ionotropic glutamate receptor activity	Gains
CO7	GO:0022824	transmitter-gated ion channel activity	Gains
CO7	GO:0022835	transmitter-gated channel activity	Gains
CO7	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
CO7	GO:0030594	neurotransmitter receptor activity	Gains
CO7	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
CO7	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
CO7	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
CO7	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
CO7	GO:0004743	pyruvate kinase activity	Gains
CO7	GO:0031420	alkali metal ion binding	Gains
CO7	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Gains
CO7	GO:0043015	gamma-tubulin binding	Gains
CO7	GO:0015408	ferric-transporting ATPase activity	Gains
CO7	GO:0051427	hormone receptor binding	Gains
CO7	GO:0070567	cytidylyltransferase activity	Gains
CO7	GO:0045289	luciferin monooxygenase activity	Gains
CO7	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
CO7	GO:0030955	potassium ion binding	Gains
CO7	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Gains
CO7	GO:0015091	ferric iron transmembrane transporter activity	Gains
CO7	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	Gains
CO7	GO:0070001	aspartic-type peptidase activity	Gains
CO7	GO:0004190	aspartic-type endopeptidase activity	Gains
CO7	GO:0008236	serine-type peptidase activity	Gains
CO7	GO:0004175	endopeptidase activity	Gains
CO7	GO:0008528	G-protein coupled peptide receptor activity	Gains
CO7	GO:0008066	glutamate receptor activity	Gains
CO7	GO:0017171	serine hydrolase activity	Gains
CO7	GO:0015075	ion transmembrane transporter activity	Gains
CO7	GO:0001653	peptide receptor activity	Gains
CO7	GO:0003960	NADPH:quinone reductase activity	Gains
CO7	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
CO7	GO:0071949	FAD binding	Gains
CO7	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
CO7	GO:0032450	maltose alpha-glucosidase activity	Losses
CO7	GO:0090599	alpha-glucosidase activity	Losses
CO7	GO:0003913	DNA photolyase activity	Losses
CO7	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
CO7	GO:0005539	glycosaminoglycan binding	Losses
CO7	GO:0015926	glucosidase activity	Losses
CO7	GO:0009881	photoreceptor activity	Losses
CO7	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
CO7	GO:0001530	lipopolysaccharide binding	Losses
CO7	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
CO7	GO:0042834	peptidoglycan binding	Losses
CO7	GO:0008187	poly-pyrimidine tract binding	Losses
CO7	GO:0010181	FMN binding	Losses
CO7	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
CO7	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
CO7	GO:0004517	nitric-oxide synthase activity	Losses
CO7	GO:0003914	DNA (6-4) photolyase activity	Losses
CO7	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
CO7	GO:0004092	carnitine O-acetyltransferase activity	Losses
CO7	GO:0015142	tricarboxylic acid transmembrane transporter activity	Losses
CO7	GO:0015137	citrate transmembrane transporter activity	Losses
CO7	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
CO7	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
CO7	GO:0008428	ribonuclease inhibitor activity	Losses
CO7	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
CO7	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
CO7	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
CO7	GO:0070576	vitamin D 24-hydroxylase activity	Losses
CO7	GO:0003873	6-phosphofructo-2-kinase activity	Losses
CO7	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
CO7	GO:0035274	diphenyl phthalate binding	Losses
CO7	GO:0035275	dibutyl phthalate binding	Losses
CO7	GO:0008201	heparin binding	Losses
CO7	GO:0042393	histone binding	Losses
CO7	GO:0015035	protein disulfide oxidoreductase activity	Losses
CO7	GO:0003727	single-stranded RNA binding	Losses
CO7	GO:0004871	signal transducer activity	Losses
CO7	GO:0004733	pyridoxamine-phosphate oxidase activity	Losses
CO7	GO:0015928	fucosidase activity	Losses
CO7	GO:0005550	pheromone binding	Losses
CO7	GO:0050833	pyruvate transmembrane transporter activity	Losses
CO7	GO:0004560	alpha-L-fucosidase activity	Losses
CO7	GO:0001872	(1->3)-beta-D-glucan binding	Losses
CO7	GO:0047429	nucleoside-triphosphate diphosphatase activity	Losses
CO7	GO:0004657	proline dehydrogenase activity	Losses
CO7	GO:0008020	G-protein coupled photoreceptor activity	Losses
CO7	GO:0015141	succinate transmembrane transporter activity	Losses
CO7	GO:0008443	phosphofructokinase activity	Losses
CO7	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
CO7	GO:0050308	sugar-phosphatase activity	Losses
CO7	GO:0009882	blue light photoreceptor activity	Losses
CO7	GO:0004102	choline O-acetyltransferase activity	Losses
CO7	GO:0032093	SAM domain binding	Losses
CO7	GO:0015036	disulfide oxidoreductase activity	Losses
CO7	GO:0050660	flavin adenine dinucleotide binding	Losses
CO7	GO:0003712	transcription cofactor activity	Losses
CO7	GO:0004872	receptor activity	Losses
CO7	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Losses
CO7	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
CO7	GO:0050824	water binding	Losses
CO7	GO:0050825	ice binding	Losses
CO7	GO:0005501	retinoid binding	Losses
CO7	GO:0042162	telomeric DNA binding	Losses
CO7	GO:0034739	histone deacetylase activity (H4-K16 specific)	Losses
CO7	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
CO7	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
CO7	GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
CO7	GO:0032129	histone deacetylase activity (H3-K9 specific)	Losses
CO7	GO:0030882	lipid antigen binding	Losses
CO7	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Losses
CO7	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
CO7	GO:0070891	lipoteichoic acid binding	Losses
CO7	GO:0016413	O-acetyltransferase activity	Losses
CO7	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Losses
CO7	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Losses
CO7	GO:0016406	carnitine O-acyltransferase activity	Losses
CO7	GO:0031078	histone deacetylase activity (H3-K14 specific)	Losses
CO7	GO:0004185	serine-type carboxypeptidase activity	Losses
CO7	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Losses
CO7	GO:0099600	transmembrane receptor activity	Losses
CO7	GO:0042393	histone binding	Extinctions
CO7	GO:0004092	carnitine O-acetyltransferase activity	Extinctions
CO7	GO:0008428	ribonuclease inhibitor activity	Extinctions
CO7	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
CO7	GO:0035274	diphenyl phthalate binding	Extinctions
CO7	GO:0035275	dibutyl phthalate binding	Extinctions
CO7	GO:0004733	pyridoxamine-phosphate oxidase activity	Extinctions
CO7	GO:0005550	pheromone binding	Extinctions
CO7	GO:0003913	DNA photolyase activity	Extinctions
CO7	GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
CO7	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
CO7	GO:0004657	proline dehydrogenase activity	Extinctions
CO7	GO:0004102	choline O-acetyltransferase activity	Extinctions
CO7	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
CO7	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
CO7	GO:0050824	water binding	Extinctions
CO7	GO:0050825	ice binding	Extinctions
CO7	GO:0005501	retinoid binding	Extinctions
CO7	GO:0042162	telomeric DNA binding	Extinctions
CO7	GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
CO7	GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
CO7	GO:0016413	O-acetyltransferase activity	Extinctions
CO7	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
CO7	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
CO7	GO:0016406	carnitine O-acyltransferase activity	Extinctions
CO7	GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
CO7	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
CO7	GO:0003713	transcription coactivator activity	Extinctions
CO7	GO:0030306	ADP-ribosylation factor binding	Extinctions
CO7	GO:0005251	delayed rectifier potassium channel activity	Extinctions
CO7	GO:0017136	NAD-dependent histone deacetylase activity	Extinctions
CO7	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Extinctions
CO7	GO:0019840	isoprenoid binding	Extinctions
CO7	GO:0005154	epidermal growth factor receptor binding	Extinctions
HY33	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY33	GO:0034061	DNA polymerase activity	Gains
HY33	GO:0005549	odorant binding	Gains
HY33	GO:0004984	olfactory receptor activity	Gains
HY33	GO:0051184	cofactor transporter activity	Gains
HY33	GO:0140097	catalytic activity, acting on DNA	Gains
HY33	GO:0016779	nucleotidyltransferase activity	Gains
HY33	GO:0004930	G-protein coupled receptor activity	Gains
HY33	GO:0051185	coenzyme transporter activity	Gains
HY33	GO:0022843	voltage-gated cation channel activity	Gains
HY33	GO:0046914	transition metal ion binding	Gains
HY33	GO:0008270	zinc ion binding	Gains
HY33	GO:0008307	structural constituent of muscle	Gains
HY33	GO:0005244	voltage-gated ion channel activity	Gains
HY33	GO:0022832	voltage-gated channel activity	Gains
HY33	GO:0070001	aspartic-type peptidase activity	Gains
HY33	GO:0004190	aspartic-type endopeptidase activity	Gains
HY33	GO:0005262	calcium channel activity	Gains
HY33	GO:0005216	ion channel activity	Gains
HY33	GO:0005245	voltage-gated calcium channel activity	Gains
HY33	GO:0022838	substrate-specific channel activity	Gains
HY33	GO:0004871	signal transducer activity	Gains
HY33	GO:0038023	signaling receptor activity	Gains
HY33	GO:0015267	channel activity	Gains
HY33	GO:0022803	passive transmembrane transporter activity	Gains
HY33	GO:0022836	gated channel activity	Gains
HY33	GO:0099600	transmembrane receptor activity	Gains
HY33	GO:0070735	protein-glycine ligase activity	Gains
HY33	GO:0070736	protein-glycine ligase activity, initiating	Gains
HY33	GO:0070737	protein-glycine ligase activity, elongating	Gains
HY33	GO:0004760	serine-pyruvate transaminase activity	Gains
HY33	GO:0018271	biotin-protein ligase activity	Gains
HY33	GO:0008086	light-activated voltage-gated calcium channel activity	Gains
HY33	GO:0010461	light-activated ion channel activity	Gains
HY33	GO:0047485	protein N-terminus binding	Gains
HY33	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Gains
HY33	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Gains
HY33	GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	Gains
HY33	GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	Gains
HY33	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Gains
HY33	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Gains
HY33	GO:0047800	cysteamine dioxygenase activity	Gains
HY33	GO:0046872	metal ion binding	Gains
HY33	GO:0043169	cation binding	Gains
HY33	GO:0015075	ion transmembrane transporter activity	Gains
HY33	GO:0004888	transmembrane signaling receptor activity	Gains
HY33	GO:0004872	receptor activity	Gains
HY33	GO:0005261	cation channel activity	Gains
HY33	GO:0008521	acetyl-CoA transporter activity	Gains
HY33	GO:0004753	saccharopine dehydrogenase activity	Gains
HY33	GO:0050824	water binding	Gains
HY33	GO:0050825	ice binding	Gains
HY33	GO:0050833	pyruvate transmembrane transporter activity	Gains
HY33	GO:0008332	low voltage-gated calcium channel activity	Gains
HY33	GO:0008453	alanine-glyoxylate transaminase activity	Gains
HY33	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Gains
HY33	GO:0004337	geranyltranstransferase activity	Gains
HY33	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
HY33	GO:0005201	extracellular matrix structural constituent	Gains
HY33	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY33	GO:0016779	nucleotidyltransferase activity	Losses
HY33	GO:0034061	DNA polymerase activity	Losses
HY33	GO:0003676	nucleic acid binding	Losses
HY33	GO:1901363	heterocyclic compound binding	Losses
HY33	GO:0097159	organic cyclic compound binding	Losses
HY33	GO:0140097	catalytic activity, acting on DNA	Losses
HY33	GO:0004312	fatty acid synthase activity	Losses
HY33	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
HY33	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
HY33	GO:0005201	extracellular matrix structural constituent	Losses
HY33	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
HY33	GO:0005506	iron ion binding	Losses
HY33	GO:0046914	transition metal ion binding	Losses
HY33	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
HY33	GO:0070330	aromatase activity	Losses
HY33	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
HY33	GO:0030414	peptidase inhibitor activity	Losses
HY33	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
HY33	GO:0048037	cofactor binding	Losses
HY33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
HY33	GO:0070001	aspartic-type peptidase activity	Losses
HY33	GO:0004190	aspartic-type endopeptidase activity	Losses
HY33	GO:0016740	transferase activity	Losses
HY33	GO:0061134	peptidase regulator activity	Losses
HY33	GO:0061598	molybdopterin adenylyltransferase activity	Losses
HY33	GO:0061599	molybdopterin molybdotransferase activity	Losses
HY33	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Losses
HY33	GO:0070856	myosin VI light chain binding	Losses
HY33	GO:0004796	thromboxane-A synthase activity	Losses
HY33	GO:0003986	acetyl-CoA hydrolase activity	Losses
HY33	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
HY33	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
HY33	GO:0001614	purinergic nucleotide receptor activity	Losses
HY33	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
HY33	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
HY33	GO:0070976	TIR domain binding	Losses
HY33	GO:0004062	aryl sulfotransferase activity	Losses
HY33	GO:0004054	arginine kinase activity	Losses
HY33	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Losses
HY33	GO:0004027	alcohol sulfotransferase activity	Losses
HY33	GO:0004995	tachykinin receptor activity	Losses
HY33	GO:0035013	myosuppressin receptor activity	Losses
HY33	GO:0015026	coreceptor activity	Losses
HY33	GO:0005436	sodium:phosphate symporter activity	Losses
HY33	GO:0004398	histidine decarboxylase activity	Losses
HY33	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Losses
HY33	GO:0016502	nucleotide receptor activity	Losses
HY33	GO:0004304	estrone sulfotransferase activity	Losses
HY33	GO:0047886	farnesol dehydrogenase activity	Losses
HY33	GO:0016618	hydroxypyruvate reductase activity	Losses
HY33	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Losses
HY33	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
HY33	GO:0019113	limonene monooxygenase activity	Losses
HY33	GO:0008887	glycerate kinase activity	Losses
HY33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
HY33	GO:0004803	transposase activity	Losses
HY33	GO:0043169	cation binding	Losses
HY33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
HY33	GO:0004930	G-protein coupled receptor activity	Losses
HY33	GO:0020037	heme binding	Losses
HY33	GO:0004888	transmembrane signaling receptor activity	Losses
HY33	GO:0046906	tetrapyrrole binding	Losses
HY33	GO:0003676	nucleic acid binding	Extinctions
HY33	GO:1901363	heterocyclic compound binding	Extinctions
HY33	GO:0097159	organic cyclic compound binding	Extinctions
HY33	GO:0030414	peptidase inhibitor activity	Extinctions
HY33	GO:0070001	aspartic-type peptidase activity	Extinctions
HY33	GO:0004190	aspartic-type endopeptidase activity	Extinctions
HY33	GO:0061134	peptidase regulator activity	Extinctions
HY33	GO:0140097	catalytic activity, acting on DNA	Extinctions
HY33	GO:0004984	olfactory receptor activity	Extinctions
HY33	GO:0005201	extracellular matrix structural constituent	Extinctions
HY33	GO:0016779	nucleotidyltransferase activity	Extinctions
HY33	GO:0034061	DNA polymerase activity	Extinctions
HY33	GO:0004857	enzyme inhibitor activity	Extinctions
HY33	GO:0030366	molybdopterin synthase activity	Extinctions
HY33	GO:0036422	heptaprenyl diphosphate synthase activity	Extinctions
HY33	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Extinctions
HY33	GO:0046899	nucleoside triphosphate adenylate kinase activity	Extinctions
HY33	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY33	GO:0005549	odorant binding	Extinctions
HY33	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	Extinctions
HY33	GO:0008172	S-methyltransferase activity	Extinctions
HMELP	GO:0005549	odorant binding	Gains
HMELP	GO:0070330	aromatase activity	Gains
HMELP	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HMELP	GO:0020037	heme binding	Gains
HMELP	GO:0046906	tetrapyrrole binding	Gains
HMELP	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
HMELP	GO:0004497	monooxygenase activity	Gains
HMELP	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
HMELP	GO:0004984	olfactory receptor activity	Gains
HMELP	GO:0005000	vasopressin receptor activity	Gains
HMELP	GO:0050591	quinine 3-monooxygenase activity	Gains
HMELP	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HMELP	GO:0018685	alkane 1-monooxygenase activity	Gains
HMELP	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
HMELP	GO:0004930	G-protein coupled receptor activity	Gains
HMELP	GO:0070001	aspartic-type peptidase activity	Gains
HMELP	GO:0004190	aspartic-type endopeptidase activity	Gains
HMELP	GO:0003964	RNA-directed DNA polymerase activity	Gains
HMELP	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Gains
HMELP	GO:0004888	transmembrane signaling receptor activity	Gains
HMELP	GO:0038023	signaling receptor activity	Gains
HMELP	GO:0008329	signaling pattern recognition receptor activity	Gains
HMELP	GO:0038187	pattern recognition receptor activity	Gains
HMELP	GO:0004896	cytokine receptor activity	Gains
HMELP	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
HMELP	GO:0016746	transferase activity, transferring acyl groups	Gains
HMELP	GO:0003777	microtubule motor activity	Gains
HMELP	GO:0015036	disulfide oxidoreductase activity	Gains
HMELP	GO:0005506	iron ion binding	Gains
HMELP	GO:0099600	transmembrane receptor activity	Gains
HMELP	GO:0140097	catalytic activity, acting on DNA	Gains
HMELP	GO:0008239	dipeptidyl-peptidase activity	Gains
HMELP	GO:0003964	RNA-directed DNA polymerase activity	Losses
HMELP	GO:0034061	DNA polymerase activity	Losses
HMELP	GO:0016779	nucleotidyltransferase activity	Losses
HMELP	GO:0004519	endonuclease activity	Losses
HMELP	GO:0140097	catalytic activity, acting on DNA	Losses
HMELP	GO:0070001	aspartic-type peptidase activity	Losses
HMELP	GO:0004190	aspartic-type endopeptidase activity	Losses
HMELP	GO:0004518	nuclease activity	Losses
HMELP	GO:0008233	peptidase activity	Losses
HMELP	GO:0008241	peptidyl-dipeptidase activity	Losses
HMELP	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HMELP	GO:0016788	hydrolase activity, acting on ester bonds	Losses
HMELP	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HMELP	GO:0016787	hydrolase activity	Losses
HMELP	GO:0004175	endopeptidase activity	Losses
HMELP	GO:0004965	G-protein coupled GABA receptor activity	Losses
HMELP	GO:0048029	monosaccharide binding	Losses
HMELP	GO:0004784	superoxide dismutase activity	Losses
HMELP	GO:0030151	molybdenum ion binding	Losses
HMELP	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
HMELP	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Losses
HMELP	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
HMELP	GO:0051213	dioxygenase activity	Losses
HMELP	GO:0019842	vitamin binding	Losses
HMELP	GO:0016879	ligase activity, forming carbon-nitrogen bonds	Losses
HMELP	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
HMELP	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
HMELP	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
HMELP	GO:0052834	inositol monophosphate phosphatase activity	Losses
HMELP	GO:0015927	trehalase activity	Losses
HMELP	GO:0015928	fucosidase activity	Losses
HMELP	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
HMELP	GO:0004971	AMPA glutamate receptor activity	Losses
HMELP	GO:0005212	structural constituent of eye lens	Losses
HMELP	GO:0008892	guanine deaminase activity	Losses
HMELP	GO:0043546	molybdopterin cofactor binding	Losses
HMELP	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
HMELP	GO:0004560	alpha-L-fucosidase activity	Losses
HMELP	GO:0004555	alpha,alpha-trehalase activity	Losses
HMELP	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
HMELP	GO:0003933	GTP cyclohydrolase activity	Losses
HMELP	GO:0003934	GTP cyclohydrolase I activity	Losses
HMELP	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
HMELP	GO:0033041	sweet taste receptor activity	Losses
HMELP	GO:0016917	GABA receptor activity	Losses
HMELP	GO:0031418	L-ascorbic acid binding	Losses
HMELP	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
HMELP	GO:0050662	coenzyme binding	Losses
HMELP	GO:0048037	cofactor binding	Losses
HMELP	GO:0008236	serine-type peptidase activity	Losses
HMELP	GO:0046914	transition metal ion binding	Losses
HMELP	GO:0004075	biotin carboxylase activity	Losses
HMELP	GO:0005213	structural constituent of chorion	Losses
HMELP	GO:0017171	serine hydrolase activity	Losses
HMELP	GO:0030414	peptidase inhibitor activity	Losses
HMELP	GO:0030545	receptor regulator activity	Losses
HMELP	GO:0016209	antioxidant activity	Losses
HMELP	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
HMELP	GO:0003779	actin binding	Losses
HMELP	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
HMELP	GO:0003723	RNA binding	Losses
HMELP	GO:0042302	structural constituent of cuticle	Losses
HMELP	GO:0019798	procollagen-proline dioxygenase activity	Losses
HMELP	GO:0005178	integrin binding	Losses
HMELP	GO:0016453	C-acetyltransferase activity	Losses
HMELP	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	Losses
HMELP	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
HMELP	GO:0019825	oxygen binding	Losses
HMELP	GO:0016755	transferase activity, transferring amino-acyl groups	Losses
HMELP	GO:0043177	organic acid binding	Losses
HMELP	GO:0031406	carboxylic acid binding	Losses
HMELP	GO:0004857	enzyme inhibitor activity	Losses
HMELP	GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
HMELP	GO:0016491	oxidoreductase activity	Losses
HMELP	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
HMELP	GO:0005506	iron ion binding	Losses
HMELP	GO:0016298	lipase activity	Losses
HMELP	GO:0004866	endopeptidase inhibitor activity	Losses
HMELP	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HMELP	GO:0034061	DNA polymerase activity	Extinctions
HMELP	GO:0004519	endonuclease activity	Extinctions
HMELP	GO:0016779	nucleotidyltransferase activity	Extinctions
HMELP	GO:0031418	L-ascorbic acid binding	Extinctions
HMELP	GO:0140097	catalytic activity, acting on DNA	Extinctions
HMELP	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
HMELP	GO:0003933	GTP cyclohydrolase activity	Extinctions
HMELP	GO:0003934	GTP cyclohydrolase I activity	Extinctions
HMELP	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Extinctions
HMELP	GO:0048029	monosaccharide binding	Extinctions
HMELP	GO:0051213	dioxygenase activity	Extinctions
HMELP	GO:0019842	vitamin binding	Extinctions
HMELP	GO:0019798	procollagen-proline dioxygenase activity	Extinctions
HMELP	GO:0005178	integrin binding	Extinctions
HMELP	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	Extinctions
HMELP	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Extinctions
HMELP	GO:0008241	peptidyl-dipeptidase activity	Extinctions
HMELP	GO:0000062	fatty-acyl-CoA binding	Extinctions
HMELP	GO:1901567	fatty acid derivative binding	Extinctions
HMELP	GO:0019238	cyclohydrolase activity	Extinctions
HMELP	GO:0004356	glutamate-ammonia ligase activity	Extinctions
HMELP	GO:0030976	thiamine pyrophosphate binding	Extinctions
HMELP	GO:0030151	molybdenum ion binding	Extinctions
HMELP	GO:0016211	ammonia ligase activity	Extinctions
HMELP	GO:0030545	receptor regulator activity	Extinctions
HMELP	GO:0052866	phosphatidylinositol phosphate phosphatase activity	Extinctions
HMELP	GO:0043177	organic acid binding	Extinctions
HMELP	GO:0031406	carboxylic acid binding	Extinctions
HMELP	GO:0030414	peptidase inhibitor activity	Extinctions
HMELP	GO:0008233	peptidase activity	Extinctions
HMELP	GO:0004518	nuclease activity	Extinctions
HMELP	GO:0019706	protein-cysteine S-palmitoyltransferase activity	Extinctions
HMELP	GO:0019707	protein-cysteine S-acyltransferase activity	Extinctions
HMELP	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Extinctions
PVENU	GO:0022843	voltage-gated cation channel activity	Gains
PVENU	GO:0005516	calmodulin binding	Gains
PVENU	GO:0003779	actin binding	Gains
PVENU	GO:0005245	voltage-gated calcium channel activity	Gains
PVENU	GO:0046873	metal ion transmembrane transporter activity	Gains
PVENU	GO:0005244	voltage-gated ion channel activity	Gains
PVENU	GO:0022832	voltage-gated channel activity	Gains
PVENU	GO:0008831	dTDP-4-dehydrorhamnose reductase activity	Gains
PVENU	GO:0005262	calcium channel activity	Gains
PVENU	GO:0005216	ion channel activity	Gains
PVENU	GO:0022838	substrate-specific channel activity	Gains
PVENU	GO:0005261	cation channel activity	Gains
PVENU	GO:0097367	carbohydrate derivative binding	Gains
PVENU	GO:0051020	GTPase binding	Gains
PVENU	GO:0004519	endonuclease activity	Gains
PVENU	GO:0004725	protein tyrosine phosphatase activity	Gains
PVENU	GO:0005328	neurotransmitter:sodium symporter activity	Gains
PVENU	GO:0015085	calcium ion transmembrane transporter activity	Gains
PVENU	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
PVENU	GO:0022803	passive transmembrane transporter activity	Gains
PVENU	GO:0015267	channel activity	Gains
PVENU	GO:0052742	phosphatidylinositol kinase activity	Gains
PVENU	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
PVENU	GO:0004430	1-phosphatidylinositol 4-kinase activity	Gains
PVENU	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
PVENU	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
PVENU	GO:0005509	calcium ion binding	Gains
PVENU	GO:0015294	solute:cation symporter activity	Gains
PVENU	GO:0017016	Ras GTPase binding	Gains
PVENU	GO:0030554	adenyl nucleotide binding	Gains
PVENU	GO:0031267	small GTPase binding	Gains
PVENU	GO:0005524	ATP binding	Gains
PVENU	GO:0016849	phosphorus-oxygen lyase activity	Gains
PVENU	GO:0003951	NAD+ kinase activity	Gains
PVENU	GO:0032559	adenyl ribonucleotide binding	Gains
PVENU	GO:0005326	neurotransmitter transporter activity	Gains
PVENU	GO:0004568	chitinase activity	Gains
PVENU	GO:0017076	purine nucleotide binding	Gains
PVENU	GO:0019992	diacylglycerol binding	Gains
PVENU	GO:0008332	low voltage-gated calcium channel activity	Gains
PVENU	GO:0070300	phosphatidic acid binding	Gains
PVENU	GO:0004363	glutathione synthase activity	Gains
PVENU	GO:0051010	microtubule plus-end binding	Gains
PVENU	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
PVENU	GO:0032553	ribonucleotide binding	Gains
PVENU	GO:0003774	motor activity	Gains
PVENU	GO:0032555	purine ribonucleotide binding	Gains
PVENU	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Gains
PVENU	GO:0016805	dipeptidase activity	Gains
PVENU	GO:0035639	purine ribonucleoside triphosphate binding	Gains
PVENU	GO:0008092	cytoskeletal protein binding	Gains
PVENU	GO:0015370	solute:sodium symporter activity	Gains
PVENU	GO:0022836	gated channel activity	Gains
PVENU	GO:0005549	odorant binding	Gains
PVENU	GO:0008061	chitin binding	Gains
PVENU	GO:0004721	phosphoprotein phosphatase activity	Gains
PVENU	GO:0030695	GTPase regulator activity	Gains
PVENU	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	Gains
PVENU	GO:0004143	diacylglycerol kinase activity	Gains
PVENU	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Gains
PVENU	GO:0004687	myosin light chain kinase activity	Gains
PVENU	GO:0015293	symporter activity	Gains
PVENU	GO:0005096	GTPase activator activity	Gains
PVENU	GO:0038024	cargo receptor activity	Gains
PVENU	GO:0008233	peptidase activity	Gains
PVENU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
PVENU	GO:0008324	cation transmembrane transporter activity	Gains
PVENU	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
PVENU	GO:0003964	RNA-directed DNA polymerase activity	Losses
PVENU	GO:0034061	DNA polymerase activity	Losses
PVENU	GO:0016779	nucleotidyltransferase activity	Losses
PVENU	GO:0004190	aspartic-type endopeptidase activity	Losses
PVENU	GO:0070001	aspartic-type peptidase activity	Losses
PVENU	GO:0140097	catalytic activity, acting on DNA	Losses
PVENU	GO:0003677	DNA binding	Losses
PVENU	GO:0003676	nucleic acid binding	Losses
PVENU	GO:1901363	heterocyclic compound binding	Losses
PVENU	GO:0097159	organic cyclic compound binding	Losses
PVENU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
PVENU	GO:0004175	endopeptidase activity	Losses
PVENU	GO:0008270	zinc ion binding	Losses
PVENU	GO:0043565	sequence-specific DNA binding	Losses
PVENU	GO:0004000	adenosine deaminase activity	Losses
PVENU	GO:0097747	RNA polymerase activity	Losses
PVENU	GO:0034062	5'-3' RNA polymerase activity	Losses
PVENU	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
PVENU	GO:0046914	transition metal ion binding	Losses
PVENU	GO:0016787	hydrolase activity	Losses
PVENU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
PVENU	GO:0003700	DNA binding transcription factor activity	Losses
PVENU	GO:0003990	acetylcholinesterase activity	Losses
PVENU	GO:0038023	signaling receptor activity	Losses
PVENU	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
PVENU	GO:0000156	phosphorelay response regulator activity	Losses
PVENU	GO:0008233	peptidase activity	Losses
PVENU	GO:0048027	mRNA 5'-UTR binding	Losses
PVENU	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
PVENU	GO:0019239	deaminase activity	Losses
PVENU	GO:0004104	cholinesterase activity	Losses
PVENU	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
PVENU	GO:0022857	transmembrane transporter activity	Losses
PVENU	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
PVENU	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
PVENU	GO:0060089	molecular transducer activity	Losses
PVENU	GO:0097472	cyclin-dependent protein kinase activity	Losses
PVENU	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Losses
PVENU	GO:0052689	carboxylic ester hydrolase activity	Losses
PVENU	GO:0004312	fatty acid synthase activity	Losses
PVENU	GO:0042562	hormone binding	Losses
PVENU	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
PVENU	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
PVENU	GO:0140110	transcription regulator activity	Losses
PVENU	GO:0004888	transmembrane signaling receptor activity	Losses
PVENU	GO:0004035	alkaline phosphatase activity	Losses
PVENU	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
PVENU	GO:0016882	cyclo-ligase activity	Losses
PVENU	GO:0017110	nucleoside-diphosphatase activity	Losses
PVENU	GO:0045134	uridine-diphosphatase activity	Losses
PVENU	GO:0008083	growth factor activity	Losses
PVENU	GO:0004871	signal transducer activity	Losses
PVENU	GO:0042302	structural constituent of cuticle	Losses
PVENU	GO:0000155	phosphorelay sensor kinase activity	Losses
PVENU	GO:0004673	protein histidine kinase activity	Losses
PVENU	GO:0099600	transmembrane receptor activity	Losses
PVENU	GO:0008514	organic anion transmembrane transporter activity	Losses
PVENU	GO:0004364	glutathione transferase activity	Losses
PVENU	GO:0003960	NADPH:quinone reductase activity	Losses
PVENU	GO:0008187	poly-pyrimidine tract binding	Losses
PVENU	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
PVENU	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Losses
PVENU	GO:0008329	signaling pattern recognition receptor activity	Losses
PVENU	GO:0004046	aminoacylase activity	Losses
PVENU	GO:0005384	manganese ion transmembrane transporter activity	Losses
PVENU	GO:0008422	beta-glucosidase activity	Losses
PVENU	GO:0016848	carbon-halide lyase activity	Losses
PVENU	GO:0050308	sugar-phosphatase activity	Losses
PVENU	GO:0005110	frizzled-2 binding	Losses
PVENU	GO:0016630	protochlorophyllide reductase activity	Losses
PVENU	GO:0008853	exodeoxyribonuclease III activity	Losses
PVENU	GO:0038187	pattern recognition receptor activity	Losses
PVENU	GO:0070883	pre-miRNA binding	Losses
PVENU	GO:0004852	uroporphyrinogen-III synthase activity	Losses
PVENU	GO:0015141	succinate transmembrane transporter activity	Losses
PVENU	GO:0004501	ecdysone 20-monooxygenase activity	Losses
PVENU	GO:0045505	dynein intermediate chain binding	Losses
PVENU	GO:0018685	alkane 1-monooxygenase activity	Losses
PVENU	GO:0005214	structural constituent of chitin-based cuticle	Losses
PVENU	GO:0008509	anion transmembrane transporter activity	Losses
PVENU	GO:0003676	nucleic acid binding	Extinctions
PVENU	GO:0003677	DNA binding	Extinctions
PVENU	GO:0004000	adenosine deaminase activity	Extinctions
PVENU	GO:0000156	phosphorelay response regulator activity	Extinctions
PVENU	GO:0016779	nucleotidyltransferase activity	Extinctions
PVENU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
PVENU	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
PVENU	GO:1901363	heterocyclic compound binding	Extinctions
PVENU	GO:0004190	aspartic-type endopeptidase activity	Extinctions
PVENU	GO:0070001	aspartic-type peptidase activity	Extinctions
PVENU	GO:0097159	organic cyclic compound binding	Extinctions
PVENU	GO:0034061	DNA polymerase activity	Extinctions
PVENU	GO:0140097	catalytic activity, acting on DNA	Extinctions
PVENU	GO:0043565	sequence-specific DNA binding	Extinctions
PVENU	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
PVENU	GO:0097747	RNA polymerase activity	Extinctions
PVENU	GO:0034062	5'-3' RNA polymerase activity	Extinctions
PVENU	GO:0003700	DNA binding transcription factor activity	Extinctions
PVENU	GO:0016882	cyclo-ligase activity	Extinctions
PVENU	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Extinctions
PVENU	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Extinctions
PVENU	GO:0008853	exodeoxyribonuclease III activity	Extinctions
PVENU	GO:0015141	succinate transmembrane transporter activity	Extinctions
PVENU	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Extinctions
PVENU	GO:0009008	DNA-methyltransferase activity	Extinctions
PVENU	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
PVENU	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
PVENU	GO:0000155	phosphorelay sensor kinase activity	Extinctions
PVENU	GO:0004673	protein histidine kinase activity	Extinctions
PVENU	GO:0019239	deaminase activity	Extinctions
PVENU	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Extinctions
LE1	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
LE1	GO:0008812	choline dehydrogenase activity	Gains
LE1	GO:0020037	heme binding	Gains
LE1	GO:0046872	metal ion binding	Gains
LE1	GO:0046906	tetrapyrrole binding	Gains
LE1	GO:0043169	cation binding	Gains
LE1	GO:0015020	glucuronosyltransferase activity	Gains
LE1	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
LE1	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
LE1	GO:0009703	nitrate reductase (NADH) activity	Gains
LE1	GO:0008747	N-acetylneuraminate lyase activity	Gains
LE1	GO:0036132	13-prostaglandin reductase activity	Gains
LE1	GO:0033932	1,3-alpha-L-fucosidase activity	Gains
LE1	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
LE1	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Gains
LE1	GO:0003986	acetyl-CoA hydrolase activity	Gains
LE1	GO:0008940	nitrate reductase activity	Gains
LE1	GO:0015438	teichoic-acid-transporting ATPase activity	Gains
LE1	GO:0015162	teichoic acid transmembrane transporter activity	Gains
LE1	GO:0004061	arylformamidase activity	Gains
LE1	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
LE1	GO:0004866	endopeptidase inhibitor activity	Gains
LE1	GO:0061135	endopeptidase regulator activity	Gains
LE1	GO:0004035	alkaline phosphatase activity	Gains
LE1	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
LE1	GO:0045735	nutrient reservoir activity	Gains
LE1	GO:0036422	heptaprenyl diphosphate synthase activity	Gains
LE1	GO:0005222	intracellular cAMP activated cation channel activity	Gains
LE1	GO:0005223	intracellular cGMP activated cation channel activity	Gains
LE1	GO:0005212	structural constituent of eye lens	Gains
LE1	GO:0004470	malic enzyme activity	Gains
LE1	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
LE1	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
LE1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
LE1	GO:0016289	CoA hydrolase activity	Gains
LE1	GO:0003680	AT DNA binding	Gains
LE1	GO:0008508	bile acid:sodium symporter activity	Gains
LE1	GO:0016833	oxo-acid-lyase activity	Gains
LE1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Gains
LE1	GO:0015928	fucosidase activity	Gains
LE1	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
LE1	GO:0004560	alpha-L-fucosidase activity	Gains
LE1	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
LE1	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
LE1	GO:0015125	bile acid transmembrane transporter activity	Gains
LE1	GO:0005506	iron ion binding	Gains
LE1	GO:0005372	water transmembrane transporter activity	Losses
LE1	GO:0015250	water channel activity	Losses
LE1	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
LE1	GO:0050840	extracellular matrix binding	Losses
LE1	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
LE1	GO:0052692	raffinose alpha-galactosidase activity	Losses
LE1	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
LE1	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
LE1	GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Losses
LE1	GO:0003998	acylphosphatase activity	Losses
LE1	GO:0004557	alpha-galactosidase activity	Losses
LE1	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
LE1	GO:0004709	MAP kinase kinase kinase activity	Losses
LE1	GO:0005044	scavenger receptor activity	Losses
LE1	GO:0004046	aminoacylase activity	Losses
LE1	GO:0004995	tachykinin receptor activity	Losses
LE1	GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Losses
LE1	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Losses
LE1	GO:0035299	inositol pentakisphosphate 2-kinase activity	Losses
LE1	GO:0008169	C-methyltransferase activity	Losses
LE1	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	Losses
LE1	GO:0005110	frizzled-2 binding	Losses
LE1	GO:0004342	glucosamine-6-phosphate deaminase activity	Losses
LE1	GO:0015095	magnesium ion transmembrane transporter activity	Losses
LE1	GO:0030580	quinone cofactor methyltransferase activity	Losses
LE1	GO:0038024	cargo receptor activity	Losses
LE1	GO:0004950	chemokine receptor activity	Losses
LE1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
LE1	GO:0033549	MAP kinase phosphatase activity	Losses
LE1	GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
LE1	GO:0015925	galactosidase activity	Losses
LE1	GO:0097157	pre-mRNA intronic binding	Losses
LE1	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
LE1	GO:0005109	frizzled binding	Losses
LE1	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Losses
LE1	GO:0004144	diacylglycerol O-acyltransferase activity	Losses
LE1	GO:0005550	pheromone binding	Losses
LE1	GO:0004736	pyruvate carboxylase activity	Losses
LE1	GO:0004896	cytokine receptor activity	Losses
LE1	GO:0004849	uridine kinase activity	Losses
LE1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Losses
LE1	GO:0016015	morphogen activity	Losses
LE1	GO:0004709	MAP kinase kinase kinase activity	Extinctions
LE1	GO:0035299	inositol pentakisphosphate 2-kinase activity	Extinctions
LE1	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	Extinctions
LE1	GO:0015095	magnesium ion transmembrane transporter activity	Extinctions
LE1	GO:0003712	transcription cofactor activity	Extinctions
LE1	GO:0000988	transcription factor activity, protein binding	Extinctions
LE1	GO:0000989	transcription factor activity, transcription factor binding	Extinctions
LE1	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
LE1	GO:0019904	protein domain specific binding	Extinctions
LE1	GO:0004144	diacylglycerol O-acyltransferase activity	Extinctions
LE1	GO:0004736	pyruvate carboxylase activity	Extinctions
LE1	GO:0001104	RNA polymerase II transcription cofactor activity	Extinctions
LE1	GO:0005057	signal transducer activity, downstream of receptor	Extinctions
LE1	GO:0042800	histone methyltransferase activity (H3-K4 specific)	Extinctions
LE1	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding	Extinctions
LE1	GO:0004075	biotin carboxylase activity	Extinctions
LE1	GO:0009055	electron transfer activity	Extinctions
LE1	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
LE1	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
LE1	GO:0016411	acylglycerol O-acyltransferase activity	Extinctions
LE1	GO:0030165	PDZ domain binding	Extinctions
AFUNE	GO:0003964	RNA-directed DNA polymerase activity	Gains
AFUNE	GO:0034061	DNA polymerase activity	Gains
AFUNE	GO:0140097	catalytic activity, acting on DNA	Gains
AFUNE	GO:0016779	nucleotidyltransferase activity	Gains
AFUNE	GO:0004190	aspartic-type endopeptidase activity	Gains
AFUNE	GO:0070001	aspartic-type peptidase activity	Gains
AFUNE	GO:0004000	adenosine deaminase activity	Gains
AFUNE	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
AFUNE	GO:0019239	deaminase activity	Gains
AFUNE	GO:0004803	transposase activity	Gains
AFUNE	GO:0003676	nucleic acid binding	Gains
AFUNE	GO:0004175	endopeptidase activity	Gains
AFUNE	GO:0004888	transmembrane signaling receptor activity	Gains
AFUNE	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
AFUNE	GO:0099600	transmembrane receptor activity	Gains
AFUNE	GO:0003723	RNA binding	Gains
AFUNE	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
AFUNE	GO:0038023	signaling receptor activity	Gains
AFUNE	GO:0004930	G-protein coupled receptor activity	Gains
AFUNE	GO:0004871	signal transducer activity	Gains
AFUNE	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
AFUNE	GO:0051371	muscle alpha-actinin binding	Gains
AFUNE	GO:0008270	zinc ion binding	Gains
AFUNE	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
AFUNE	GO:0008233	peptidase activity	Gains
AFUNE	GO:0000976	transcription regulatory region sequence-specific DNA binding	Gains
AFUNE	GO:0003677	DNA binding	Gains
AFUNE	GO:1990837	sequence-specific double-stranded DNA binding	Gains
AFUNE	GO:0044212	transcription regulatory region DNA binding	Gains
AFUNE	GO:0000975	regulatory region DNA binding	Gains
AFUNE	GO:0001067	regulatory region nucleic acid binding	Gains
AFUNE	GO:0051393	alpha-actinin binding	Gains
AFUNE	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Gains
AFUNE	GO:0042805	actinin binding	Gains
AFUNE	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Gains
AFUNE	GO:0004872	receptor activity	Gains
AFUNE	GO:0060089	molecular transducer activity	Gains
AFUNE	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
AFUNE	GO:0001012	RNA polymerase II regulatory region DNA binding	Gains
AFUNE	GO:0046914	transition metal ion binding	Gains
AFUNE	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
AFUNE	GO:0004519	endonuclease activity	Gains
AFUNE	GO:0003690	double-stranded DNA binding	Gains
AFUNE	GO:0043565	sequence-specific DNA binding	Gains
AFUNE	GO:0005216	ion channel activity	Gains
AFUNE	GO:0022838	substrate-specific channel activity	Gains
AFUNE	GO:0001158	enhancer sequence-specific DNA binding	Gains
AFUNE	GO:0035326	enhancer binding	Gains
AFUNE	GO:0015267	channel activity	Gains
AFUNE	GO:0022803	passive transmembrane transporter activity	Gains
AFUNE	GO:0030594	neurotransmitter receptor activity	Gains
AFUNE	GO:0003700	DNA binding transcription factor activity	Gains
AFUNE	GO:1901363	heterocyclic compound binding	Gains
AFUNE	GO:0097159	organic cyclic compound binding	Gains
AFUNE	GO:0004518	nuclease activity	Gains
AFUNE	GO:0022824	transmitter-gated ion channel activity	Gains
AFUNE	GO:0022835	transmitter-gated channel activity	Gains
AFUNE	GO:0004970	ionotropic glutamate receptor activity	Gains
AFUNE	GO:0004332	fructose-bisphosphate aldolase activity	Gains
AFUNE	GO:0016085	myoinhibitory hormone activity	Gains
AFUNE	GO:0008515	sucrose transmembrane transporter activity	Gains
AFUNE	GO:0016933	extracellularly glycine-gated ion channel activity	Gains
AFUNE	GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Gains
AFUNE	GO:0001784	phosphotyrosine residue binding	Gains
AFUNE	GO:0015280	ligand-gated sodium channel activity	Gains
AFUNE	GO:0044736	acid-sensing ion channel activity	Gains
AFUNE	GO:0005043	netrin receptor activity involved in chemorepulsion	Gains
AFUNE	GO:0016499	orexin receptor activity	Gains
AFUNE	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
AFUNE	GO:0004516	nicotinate phosphoribosyltransferase activity	Gains
AFUNE	GO:0001614	purinergic nucleotide receptor activity	Gains
AFUNE	GO:0097493	structural molecule activity conferring elasticity	Gains
AFUNE	GO:0031005	filamin binding	Gains
AFUNE	GO:0060308	GTP cyclohydrolase I regulator activity	Gains
AFUNE	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
AFUNE	GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	Gains
AFUNE	GO:0097109	neuroligin family protein binding	Gains
AFUNE	GO:0005430	synaptic vesicle amine transmembrane transporter activity	Gains
AFUNE	GO:0045309	protein phosphorylated amino acid binding	Gains
AFUNE	GO:0050840	extracellular matrix binding	Gains
AFUNE	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
AFUNE	GO:0005275	amine transmembrane transporter activity	Gains
AFUNE	GO:0016502	nucleotide receptor activity	Gains
AFUNE	GO:0036401	pyrokinin receptor activity	Gains
AFUNE	GO:0034185	apolipoprotein binding	Gains
AFUNE	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
AFUNE	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
AFUNE	GO:0004857	enzyme inhibitor activity	Losses
AFUNE	GO:0008376	acetylgalactosaminyltransferase activity	Losses
AFUNE	GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
AFUNE	GO:0061134	peptidase regulator activity	Losses
AFUNE	GO:0030414	peptidase inhibitor activity	Losses
AFUNE	GO:0016783	sulfurtransferase activity	Losses
AFUNE	GO:0005501	retinoid binding	Losses
AFUNE	GO:0019840	isoprenoid binding	Losses
AFUNE	GO:0004551	nucleotide diphosphatase activity	Losses
AFUNE	GO:0005343	organic acid:sodium symporter activity	Losses
AFUNE	GO:0030234	enzyme regulator activity	Losses
AFUNE	GO:0004129	cytochrome-c oxidase activity	Losses
AFUNE	GO:0015002	heme-copper terminal oxidase activity	Losses
AFUNE	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
AFUNE	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
AFUNE	GO:0004866	endopeptidase inhibitor activity	Losses
AFUNE	GO:0000339	RNA cap binding	Losses
AFUNE	GO:0008252	nucleotidase activity	Losses
AFUNE	GO:0061135	endopeptidase regulator activity	Losses
AFUNE	GO:0005215	transporter activity	Losses
AFUNE	GO:0015293	symporter activity	Losses
AFUNE	GO:0022890	inorganic cation transmembrane transporter activity	Losses
AFUNE	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
AFUNE	GO:0015370	solute:sodium symporter activity	Losses
AFUNE	GO:0035250	UDP-galactosyltransferase activity	Losses
AFUNE	GO:0031369	translation initiation factor binding	Losses
AFUNE	GO:0061605	molybdopterin-synthase adenylyltransferase activity	Losses
AFUNE	GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	Losses
AFUNE	GO:0004490	methylglutaconyl-CoA hydratase activity	Losses
AFUNE	GO:0004479	methionyl-tRNA formyltransferase activity	Losses
AFUNE	GO:0003874	6-pyruvoyltetrahydropterin synthase activity	Losses
AFUNE	GO:0004408	holocytochrome-c synthase activity	Losses
AFUNE	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity	Losses
AFUNE	GO:0050093	methanol dehydrogenase activity	Losses
AFUNE	GO:0016019	peptidoglycan receptor activity	Losses
AFUNE	GO:0019811	cocaine binding	Losses
AFUNE	GO:0008508	bile acid:sodium symporter activity	Losses
AFUNE	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
AFUNE	GO:0047964	glyoxylate reductase activity	Losses
AFUNE	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
AFUNE	GO:0016918	retinal binding	Losses
AFUNE	GO:0042943	D-amino acid transmembrane transporter activity	Losses
AFUNE	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
AFUNE	GO:0015125	bile acid transmembrane transporter activity	Losses
AFUNE	GO:0015250	water channel activity	Losses
AFUNE	GO:0015222	serotonin transmembrane transporter activity	Losses
AFUNE	GO:0001729	ceramide kinase activity	Losses
AFUNE	GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	Losses
AFUNE	GO:0030267	glyoxylate reductase (NADP) activity	Losses
AFUNE	GO:0001875	lipopolysaccharide receptor activity	Losses
AFUNE	GO:0004556	alpha-amylase activity	Losses
AFUNE	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity	Losses
AFUNE	GO:0003940	L-iduronidase activity	Losses
AFUNE	GO:0003945	N-acetyllactosamine synthase activity	Losses
AFUNE	GO:0016427	tRNA (cytosine) methyltransferase activity	Losses
AFUNE	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	Losses
AFUNE	GO:0000210	NAD+ diphosphatase activity	Losses
AFUNE	GO:0016160	amylase activity	Losses
AFUNE	GO:0004631	phosphomevalonate kinase activity	Losses
AFUNE	GO:0005372	water transmembrane transporter activity	Losses
AFUNE	GO:0008331	high voltage-gated calcium channel activity	Losses
AFUNE	GO:0005329	dopamine transmembrane transporter activity	Losses
AFUNE	GO:0032500	muramyl dipeptide binding	Losses
AFUNE	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Losses
AFUNE	GO:0005415	nucleoside:sodium symporter activity	Losses
AFUNE	GO:0035274	diphenyl phthalate binding	Losses
AFUNE	GO:0035275	dibutyl phthalate binding	Losses
AFUNE	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Losses
AFUNE	GO:0047886	farnesol dehydrogenase activity	Losses
AFUNE	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Losses
AFUNE	GO:0031370	eukaryotic initiation factor 4G binding	Losses
AFUNE	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Losses
AFUNE	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Losses
AFUNE	GO:0005213	structural constituent of chorion	Losses
AFUNE	GO:0004321	fatty-acyl-CoA synthase activity	Losses
AFUNE	GO:0061604	molybdopterin-synthase sulfurtransferase activity	Losses
AFUNE	GO:0008194	UDP-glycosyltransferase activity	Losses
AFUNE	GO:0004180	carboxypeptidase activity	Losses
AFUNE	GO:0004857	enzyme inhibitor activity	Extinctions
AFUNE	GO:0003735	structural constituent of ribosome	Extinctions
AFUNE	GO:0004551	nucleotide diphosphatase activity	Extinctions
AFUNE	GO:0061134	peptidase regulator activity	Extinctions
AFUNE	GO:0000339	RNA cap binding	Extinctions
AFUNE	GO:0008135	translation factor activity, RNA binding	Extinctions
AFUNE	GO:0003743	translation initiation factor activity	Extinctions
AFUNE	GO:0030414	peptidase inhibitor activity	Extinctions
AFUNE	GO:0031369	translation initiation factor binding	Extinctions
AFUNE	GO:0005198	structural molecule activity	Extinctions
AFUNE	GO:0016783	sulfurtransferase activity	Extinctions
AFUNE	GO:0016860	intramolecular oxidoreductase activity	Extinctions
AFUNE	GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	Extinctions
AFUNE	GO:0004479	methionyl-tRNA formyltransferase activity	Extinctions
AFUNE	GO:0003874	6-pyruvoyltetrahydropterin synthase activity	Extinctions
AFUNE	GO:0004408	holocytochrome-c synthase activity	Extinctions
AFUNE	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity	Extinctions
AFUNE	GO:0050093	methanol dehydrogenase activity	Extinctions
AFUNE	GO:0008508	bile acid:sodium symporter activity	Extinctions
AFUNE	GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Extinctions
AFUNE	GO:0015125	bile acid transmembrane transporter activity	Extinctions
AFUNE	GO:0001729	ceramide kinase activity	Extinctions
AFUNE	GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	Extinctions
AFUNE	GO:0003940	L-iduronidase activity	Extinctions
AFUNE	GO:0003945	N-acetyllactosamine synthase activity	Extinctions
AFUNE	GO:0016427	tRNA (cytosine) methyltransferase activity	Extinctions
AFUNE	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	Extinctions
AFUNE	GO:0000210	NAD+ diphosphatase activity	Extinctions
AFUNE	GO:0004631	phosphomevalonate kinase activity	Extinctions
AFUNE	GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
AFUNE	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Extinctions
AFUNE	GO:0031370	eukaryotic initiation factor 4G binding	Extinctions
AFUNE	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	Extinctions
AFUNE	GO:0005213	structural constituent of chorion	Extinctions
AFUNE	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Extinctions
AFUNE	GO:0008376	acetylgalactosaminyltransferase activity	Extinctions
AFUNE	GO:0008175	tRNA methyltransferase activity	Extinctions
AR1	GO:0034061	DNA polymerase activity	Gains
AR1	GO:0003964	RNA-directed DNA polymerase activity	Gains
AR1	GO:0003676	nucleic acid binding	Gains
AR1	GO:0003677	DNA binding	Gains
AR1	GO:0140097	catalytic activity, acting on DNA	Gains
AR1	GO:0097159	organic cyclic compound binding	Gains
AR1	GO:1901363	heterocyclic compound binding	Gains
AR1	GO:0008239	dipeptidyl-peptidase activity	Gains
AR1	GO:0005216	ion channel activity	Gains
AR1	GO:0022838	substrate-specific channel activity	Gains
AR1	GO:0022803	passive transmembrane transporter activity	Gains
AR1	GO:0015267	channel activity	Gains
AR1	GO:0005488	binding	Gains
AR1	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	Gains
AR1	GO:0003700	DNA binding transcription factor activity	Gains
AR1	GO:0004518	nuclease activity	Gains
AR1	GO:0022857	transmembrane transporter activity	Gains
AR1	GO:0016779	nucleotidyltransferase activity	Gains
AR1	GO:0140110	transcription regulator activity	Gains
AR1	GO:0004143	diacylglycerol kinase activity	Gains
AR1	GO:0015075	ion transmembrane transporter activity	Gains
AR1	GO:0070001	aspartic-type peptidase activity	Gains
AR1	GO:0004190	aspartic-type endopeptidase activity	Gains
AR1	GO:0008509	anion transmembrane transporter activity	Gains
AR1	GO:0015103	inorganic anion transmembrane transporter activity	Gains
AR1	GO:0005096	GTPase activator activity	Gains
AR1	GO:0035091	phosphatidylinositol binding	Gains
AR1	GO:0003951	NAD+ kinase activity	Gains
AR1	GO:0005230	extracellular ligand-gated ion channel activity	Gains
AR1	GO:0019239	deaminase activity	Gains
AR1	GO:0022891	substrate-specific transmembrane transporter activity	Gains
AR1	GO:0005215	transporter activity	Gains
AR1	GO:0008047	enzyme activator activity	Gains
AR1	GO:0016174	NAD(P)H oxidase activity	Gains
AR1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Gains
AR1	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Gains
AR1	GO:0008253	5'-nucleotidase activity	Gains
AR1	GO:0005254	chloride channel activity	Gains
AR1	GO:0005253	anion channel activity	Gains
AR1	GO:0030695	GTPase regulator activity	Gains
AR1	GO:0043169	cation binding	Gains
AR1	GO:0004016	adenylate cyclase activity	Gains
AR1	GO:0008525	phosphatidylcholine transporter activity	Losses
AR1	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
AR1	GO:0008395	steroid hydroxylase activity	Losses
AR1	GO:0019199	transmembrane receptor protein kinase activity	Losses
AR1	GO:0003964	RNA-directed DNA polymerase activity	Losses
AR1	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Losses
AR1	GO:0070008	serine-type exopeptidase activity	Losses
AR1	GO:0034061	DNA polymerase activity	Losses
AR1	GO:0140097	catalytic activity, acting on DNA	Losses
AR1	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
AR1	GO:0005506	iron ion binding	Losses
AR1	GO:0016779	nucleotidyltransferase activity	Losses
AR1	GO:0004697	protein kinase C activity	Losses
AR1	GO:0046914	transition metal ion binding	Losses
AR1	GO:0046872	metal ion binding	Losses
AR1	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
AR1	GO:1902936	phosphatidylinositol bisphosphate binding	Losses
AR1	GO:0043169	cation binding	Losses
AR1	GO:0033904	dextranase activity	Losses
AR1	GO:0032183	SUMO binding	Losses
AR1	GO:0004802	transketolase activity	Losses
AR1	GO:0070576	vitamin D 24-hydroxylase activity	Losses
AR1	GO:0070577	lysine-acetylated histone binding	Losses
AR1	GO:0016155	formyltetrahydrofolate dehydrogenase activity	Losses
AR1	GO:0005006	epidermal growth factor-activated receptor activity	Losses
AR1	GO:0004014	adenosylmethionine decarboxylase activity	Losses
AR1	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	Losses
AR1	GO:0050699	WW domain binding	Losses
AR1	GO:0008426	protein kinase C inhibitor activity	Losses
AR1	GO:0140033	acetylation-dependent protein binding	Losses
AR1	GO:0005415	nucleoside:sodium symporter activity	Losses
AR1	GO:0032028	myosin head/neck binding	Losses
AR1	GO:0031489	myosin V binding	Losses
AR1	GO:0050072	m7G(5')pppN diphosphatase activity	Losses
AR1	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
AR1	GO:0005213	structural constituent of chorion	Losses
AR1	GO:0008705	methionine synthase activity	Losses
AR1	GO:0008873	gluconate 2-dehydrogenase activity	Losses
AR1	GO:0008875	gluconate dehydrogenase activity	Losses
AR1	GO:0008526	phosphatidylinositol transporter activity	Losses
AR1	GO:0004756	selenide, water dikinase activity	Losses
AR1	GO:0000404	heteroduplex DNA loop binding	Losses
AR1	GO:0000406	double-strand/single-strand DNA junction binding	Losses
AR1	GO:0070854	myosin VI heavy chain binding	Losses
AR1	GO:0070855	myosin VI head/neck binding	Losses
AR1	GO:0042767	ecdysteroid 22-hydroxylase activity	Losses
AR1	GO:0015370	solute:sodium symporter activity	Losses
AR1	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
AR1	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
AR1	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	Extinctions
AR1	GO:0005415	nucleoside:sodium symporter activity	Extinctions
AR1	GO:0050072	m7G(5')pppN diphosphatase activity	Extinctions
AR1	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
AR1	GO:0005213	structural constituent of chorion	Extinctions
AR1	GO:0008705	methionine synthase activity	Extinctions
AR1	GO:0003979	UDP-glucose 6-dehydrogenase activity	Extinctions
AR1	GO:0050824	water binding	Extinctions
AR1	GO:0050825	ice binding	Extinctions
AR1	GO:0047631	ADP-ribose diphosphatase activity	Extinctions
AR1	GO:0004411	homogentisate 1,2-dioxygenase activity	Extinctions
AR1	GO:0004791	thioredoxin-disulfide reductase activity	Extinctions
AR1	GO:0003777	microtubule motor activity	Extinctions
AR1	GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
AR1	GO:0004511	tyrosine 3-monooxygenase activity	Extinctions
AR1	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Extinctions
AR1	GO:0005000	vasopressin receptor activity	Extinctions
AR1	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
AR1	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
AR1	GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	Extinctions
AR1	GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
AR1	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Extinctions
AR1	GO:0008140	cAMP response element binding protein binding	Extinctions
AR1	GO:0004357	glutamate-cysteine ligase activity	Extinctions
AR1	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
AR1	GO:0031419	cobalamin binding	Extinctions
AR1	GO:0008831	dTDP-4-dehydrorhamnose reductase activity	Extinctions
AR1	GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
AR1	GO:0003681	bent DNA binding	Extinctions
AR1	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
AR3	GO:0005179	hormone activity	Gains
AR3	GO:0048018	receptor ligand activity	Gains
AR3	GO:0031409	pigment binding	Gains
AR3	GO:0030545	receptor regulator activity	Gains
AR3	GO:0004803	transposase activity	Gains
AR3	GO:0005184	neuropeptide hormone activity	Gains
AR3	GO:0005214	structural constituent of chitin-based cuticle	Gains
AR3	GO:0042302	structural constituent of cuticle	Gains
AR3	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
AR3	GO:0019206	nucleoside kinase activity	Gains
AR3	GO:0098772	molecular function regulator	Gains
AR3	GO:0004797	thymidine kinase activity	Gains
AR3	GO:0004190	aspartic-type endopeptidase activity	Gains
AR3	GO:0070001	aspartic-type peptidase activity	Gains
AR3	GO:0019205	nucleobase-containing compound kinase activity	Gains
AR3	GO:0004385	guanylate kinase activity	Gains
AR3	GO:0016504	peptidase activator activity	Gains
AR3	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Gains
AR3	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
AR3	GO:0042910	xenobiotic transmembrane transporter activity	Gains
AR3	GO:0019136	deoxynucleoside kinase activity	Gains
AR3	GO:0042043	neurexin family protein binding	Gains
AR3	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Gains
AR3	GO:0018454	acetoacetyl-CoA reductase activity	Gains
AR3	GO:0061134	peptidase regulator activity	Gains
AR3	GO:0019201	nucleotide kinase activity	Gains
AR3	GO:0003964	RNA-directed DNA polymerase activity	Losses
AR3	GO:0034061	DNA polymerase activity	Losses
AR3	GO:0003676	nucleic acid binding	Losses
AR3	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
AR3	GO:0004888	transmembrane signaling receptor activity	Losses
AR3	GO:0038023	signaling receptor activity	Losses
AR3	GO:0043565	sequence-specific DNA binding	Losses
AR3	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
AR3	GO:0003700	DNA binding transcription factor activity	Losses
AR3	GO:0099600	transmembrane receptor activity	Losses
AR3	GO:0016779	nucleotidyltransferase activity	Losses
AR3	GO:0004871	signal transducer activity	Losses
AR3	GO:0003677	DNA binding	Losses
AR3	GO:1901363	heterocyclic compound binding	Losses
AR3	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
AR3	GO:0097159	organic cyclic compound binding	Losses
AR3	GO:0005452	inorganic anion exchanger activity	Losses
AR3	GO:0140097	catalytic activity, acting on DNA	Losses
AR3	GO:0046914	transition metal ion binding	Losses
AR3	GO:0008270	zinc ion binding	Losses
AR3	GO:0019199	transmembrane receptor protein kinase activity	Losses
AR3	GO:0060089	molecular transducer activity	Losses
AR3	GO:0004872	receptor activity	Losses
AR3	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
AR3	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
AR3	GO:0140110	transcription regulator activity	Losses
AR3	GO:1990837	sequence-specific double-stranded DNA binding	Losses
AR3	GO:0004190	aspartic-type endopeptidase activity	Losses
AR3	GO:0070001	aspartic-type peptidase activity	Losses
AR3	GO:0015103	inorganic anion transmembrane transporter activity	Losses
AR3	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
AR3	GO:0046872	metal ion binding	Losses
AR3	GO:0032947	protein complex scaffold activity	Losses
AR3	GO:0043169	cation binding	Losses
AR3	GO:0004560	alpha-L-fucosidase activity	Losses
AR3	GO:0022833	mechanically gated channel activity	Losses
AR3	GO:0030366	molybdopterin synthase activity	Losses
AR3	GO:0015928	fucosidase activity	Losses
AR3	GO:0008381	mechanically-gated ion channel activity	Losses
AR3	GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
AR3	GO:0044212	transcription regulatory region DNA binding	Losses
AR3	GO:0015075	ion transmembrane transporter activity	Losses
AR3	GO:0000975	regulatory region DNA binding	Losses
AR3	GO:0001067	regulatory region nucleic acid binding	Losses
AR3	GO:0005509	calcium ion binding	Losses
AR3	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
AR3	GO:0004620	phospholipase activity	Losses
AR3	GO:0008509	anion transmembrane transporter activity	Losses
AR3	GO:0005261	cation channel activity	Losses
AR3	GO:0005488	binding	Losses
AR3	GO:0046873	metal ion transmembrane transporter activity	Losses
AR3	GO:0015291	secondary active transmembrane transporter activity	Losses
AR3	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
AR3	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Losses
AR3	GO:0004344	glucose dehydrogenase activity	Losses
AR3	GO:0008241	peptidyl-dipeptidase activity	Losses
AR3	GO:0004430	1-phosphatidylinositol 4-kinase activity	Losses
AR3	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
AR3	GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
AR3	GO:0000340	RNA 7-methylguanosine cap binding	Losses
AR3	GO:0008812	choline dehydrogenase activity	Losses
AR3	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
AR3	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
AR3	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Losses
AR3	GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
AR3	GO:0005078	MAP-kinase scaffold activity	Losses
AR3	GO:0008190	eukaryotic initiation factor 4E binding	Losses
AR3	GO:0016740	transferase activity	Losses
AR3	GO:0022891	substrate-specific transmembrane transporter activity	Losses
AR3	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Losses
AR3	GO:0003690	double-stranded DNA binding	Losses
AR3	GO:0022892	substrate-specific transporter activity	Losses
AR3	GO:0022857	transmembrane transporter activity	Losses
AR3	GO:0004930	G-protein coupled receptor activity	Losses
AR3	GO:0031369	translation initiation factor binding	Losses
AR3	GO:0035251	UDP-glucosyltransferase activity	Losses
AR3	GO:0004713	protein tyrosine kinase activity	Losses
AR3	GO:0016782	transferase activity, transferring sulfur-containing groups	Losses
AR3	GO:0005216	ion channel activity	Losses
AR3	GO:0001012	RNA polymerase II regulatory region DNA binding	Losses
AR3	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AR3	GO:0003676	nucleic acid binding	Extinctions
AR3	GO:0030366	molybdopterin synthase activity	Extinctions
AR3	GO:0034061	DNA polymerase activity	Extinctions
AR3	GO:0005452	inorganic anion exchanger activity	Extinctions
AR3	GO:0032947	protein complex scaffold activity	Extinctions
AR3	GO:0016782	transferase activity, transferring sulfur-containing groups	Extinctions
AR3	GO:0140097	catalytic activity, acting on DNA	Extinctions
AR3	GO:0008378	galactosyltransferase activity	Extinctions
AR3	GO:1901363	heterocyclic compound binding	Extinctions
AR3	GO:0016209	antioxidant activity	Extinctions
AR3	GO:0097159	organic cyclic compound binding	Extinctions
AR3	GO:0016779	nucleotidyltransferase activity	Extinctions
AR3	GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
AR3	GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
AR3	GO:0008747	N-acetylneuraminate lyase activity	Extinctions
AR3	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	Extinctions
AR3	GO:0019841	retinol binding	Extinctions
AR3	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Extinctions
AR3	GO:0004734	pyrimidodiazepine synthase activity	Extinctions
AR3	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
AR3	GO:0005504	fatty acid binding	Extinctions
AR3	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
AR3	GO:0008022	protein C-terminus binding	Extinctions
AR3	GO:0008919	lipopolysaccharide glucosyltransferase I activity	Extinctions
AR3	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity	Extinctions
AR3	GO:0031434	mitogen-activated protein kinase kinase binding	Extinctions
AR3	GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	Extinctions
AR3	GO:0030159	receptor signaling complex scaffold activity	Extinctions
AR3	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Extinctions
AR3	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Extinctions
AR3	GO:0033041	sweet taste receptor activity	Extinctions
AR3	GO:0016405	CoA-ligase activity	Extinctions
AR3	GO:0004601	peroxidase activity	Extinctions
AR3	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Extinctions
LALBI	GO:0003964	RNA-directed DNA polymerase activity	Gains
LALBI	GO:0034061	DNA polymerase activity	Gains
LALBI	GO:0004984	olfactory receptor activity	Gains
LALBI	GO:0005549	odorant binding	Gains
LALBI	GO:0140097	catalytic activity, acting on DNA	Gains
LALBI	GO:0016779	nucleotidyltransferase activity	Gains
LALBI	GO:0003676	nucleic acid binding	Gains
LALBI	GO:0004930	G-protein coupled receptor activity	Gains
LALBI	GO:0004888	transmembrane signaling receptor activity	Gains
LALBI	GO:0038023	signaling receptor activity	Gains
LALBI	GO:0099600	transmembrane receptor activity	Gains
LALBI	GO:0008307	structural constituent of muscle	Gains
LALBI	GO:0070001	aspartic-type peptidase activity	Gains
LALBI	GO:0004190	aspartic-type endopeptidase activity	Gains
LALBI	GO:0005488	binding	Gains
LALBI	GO:0008270	zinc ion binding	Gains
LALBI	GO:1901363	heterocyclic compound binding	Gains
LALBI	GO:0097159	organic cyclic compound binding	Gains
LALBI	GO:0046914	transition metal ion binding	Gains
LALBI	GO:0004518	nuclease activity	Gains
LALBI	GO:0060089	molecular transducer activity	Gains
LALBI	GO:0004872	receptor activity	Gains
LALBI	GO:0003677	DNA binding	Gains
LALBI	GO:0004871	signal transducer activity	Gains
LALBI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
LALBI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
LALBI	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
LALBI	GO:0004950	chemokine receptor activity	Gains
LALBI	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
LALBI	GO:0004896	cytokine receptor activity	Gains
LALBI	GO:0043169	cation binding	Gains
LALBI	GO:0004364	glutathione transferase activity	Gains
LALBI	GO:0004104	cholinesterase activity	Gains
LALBI	GO:0003990	acetylcholinesterase activity	Gains
LALBI	GO:0046872	metal ion binding	Gains
LALBI	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
LALBI	GO:0031386	protein tag	Gains
LALBI	GO:0004565	beta-galactosidase activity	Gains
LALBI	GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
LALBI	GO:0008332	low voltage-gated calcium channel activity	Gains
LALBI	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
LALBI	GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
LALBI	GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
LALBI	GO:0052834	inositol monophosphate phosphatase activity	Gains
LALBI	GO:0022843	voltage-gated cation channel activity	Gains
LALBI	GO:0004075	biotin carboxylase activity	Gains
LALBI	GO:0003723	RNA binding	Gains
LALBI	GO:0005245	voltage-gated calcium channel activity	Gains
LALBI	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
LALBI	GO:0035299	inositol pentakisphosphate 2-kinase activity	Gains
LALBI	GO:0071855	neuropeptide receptor binding	Gains
LALBI	GO:0015925	galactosidase activity	Gains
LALBI	GO:0030898	actin-dependent ATPase activity	Gains
LALBI	GO:0008329	signaling pattern recognition receptor activity	Gains
LALBI	GO:0038187	pattern recognition receptor activity	Gains
LALBI	GO:0016740	transferase activity	Gains
LALBI	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
LALBI	GO:1990939	ATP-dependent microtubule motor activity	Gains
LALBI	GO:0004781	sulfate adenylyltransferase (ATP) activity	Gains
LALBI	GO:0004779	sulfate adenylyltransferase activity	Gains
LALBI	GO:0004857	enzyme inhibitor activity	Losses
LALBI	GO:0030414	peptidase inhibitor activity	Losses
LALBI	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Losses
LALBI	GO:0061134	peptidase regulator activity	Losses
LALBI	GO:0045735	nutrient reservoir activity	Losses
LALBI	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Losses
LALBI	GO:0030234	enzyme regulator activity	Losses
LALBI	GO:0005385	zinc ion transmembrane transporter activity	Losses
LALBI	GO:0098772	molecular function regulator	Losses
LALBI	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
LALBI	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
LALBI	GO:0034062	5'-3' RNA polymerase activity	Losses
LALBI	GO:0097747	RNA polymerase activity	Losses
LALBI	GO:0004866	endopeptidase inhibitor activity	Losses
LALBI	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
LALBI	GO:0005214	structural constituent of chitin-based cuticle	Losses
LALBI	GO:0061135	endopeptidase regulator activity	Losses
LALBI	GO:0017169	CDP-alcohol phosphatidyltransferase activity	Losses
LALBI	GO:0046915	transition metal ion transmembrane transporter activity	Losses
LALBI	GO:0004521	endoribonuclease activity	Losses
LALBI	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Losses
LALBI	GO:0050660	flavin adenine dinucleotide binding	Losses
LALBI	GO:0004540	ribonuclease activity	Losses
LALBI	GO:0015020	glucuronosyltransferase activity	Losses
LALBI	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
LALBI	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
LALBI	GO:0042302	structural constituent of cuticle	Losses
LALBI	GO:0005122	torso binding	Losses
LALBI	GO:0004351	glutamate decarboxylase activity	Losses
LALBI	GO:0004355	glutamate synthase (NADPH) activity	Losses
LALBI	GO:0033897	ribonuclease T2 activity	Losses
LALBI	GO:0005219	ryanodine-sensitive calcium-release channel activity	Losses
LALBI	GO:0042979	ornithine decarboxylase regulator activity	Losses
LALBI	GO:0004782	sulfinoalanine decarboxylase activity	Losses
LALBI	GO:0004735	pyrroline-5-carboxylate reductase activity	Losses
LALBI	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
LALBI	GO:0003985	acetyl-CoA C-acetyltransferase activity	Losses
LALBI	GO:0015054	gastrin receptor activity	Losses
LALBI	GO:0003919	FMN adenylyltransferase activity	Losses
LALBI	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
LALBI	GO:0050221	prostaglandin-E2 9-reductase activity	Losses
LALBI	GO:0046583	cation efflux transmembrane transporter activity	Losses
LALBI	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
LALBI	GO:0015930	glutamate synthase activity	Losses
LALBI	GO:0016603	glutaminyl-peptide cyclotransferase activity	Losses
LALBI	GO:0030544	Hsp70 protein binding	Losses
LALBI	GO:0004068	aspartate 1-decarboxylase activity	Losses
LALBI	GO:0022883	zinc efflux transmembrane transporter activity	Losses
LALBI	GO:0048495	Roundabout binding	Losses
LALBI	GO:0018445	prothoracicotrophic hormone activity	Losses
LALBI	GO:0016040	glutamate synthase (NADH) activity	Losses
LALBI	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Losses
LALBI	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Losses
LALBI	GO:0005436	sodium:phosphate symporter activity	Losses
LALBI	GO:0045181	glutamate synthase activity, NAD(P)H as acceptor	Losses
LALBI	GO:0016491	oxidoreductase activity	Losses
LALBI	GO:0004857	enzyme inhibitor activity	Extinctions
LALBI	GO:0005385	zinc ion transmembrane transporter activity	Extinctions
LALBI	GO:0030414	peptidase inhibitor activity	Extinctions
LALBI	GO:0061134	peptidase regulator activity	Extinctions
LALBI	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
LALBI	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Extinctions
LALBI	GO:0046915	transition metal ion transmembrane transporter activity	Extinctions
LALBI	GO:0017169	CDP-alcohol phosphatidyltransferase activity	Extinctions
LALBI	GO:0034062	5'-3' RNA polymerase activity	Extinctions
LALBI	GO:0097747	RNA polymerase activity	Extinctions
LALBI	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Extinctions
LALBI	GO:0098772	molecular function regulator	Extinctions
LALBI	GO:0015020	glucuronosyltransferase activity	Extinctions
LALBI	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
LALBI	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
LALBI	GO:0005122	torso binding	Extinctions
LALBI	GO:0033897	ribonuclease T2 activity	Extinctions
LALBI	GO:0005219	ryanodine-sensitive calcium-release channel activity	Extinctions
LALBI	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
LALBI	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
LALBI	GO:0015054	gastrin receptor activity	Extinctions
LALBI	GO:0050221	prostaglandin-E2 9-reductase activity	Extinctions
LALBI	GO:0046583	cation efflux transmembrane transporter activity	Extinctions
LALBI	GO:0016603	glutaminyl-peptide cyclotransferase activity	Extinctions
LALBI	GO:0030544	Hsp70 protein binding	Extinctions
LALBI	GO:0022883	zinc efflux transmembrane transporter activity	Extinctions
LALBI	GO:0048495	Roundabout binding	Extinctions
LALBI	GO:0018445	prothoracicotrophic hormone activity	Extinctions
LALBI	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Extinctions
LALBI	GO:0072509	divalent inorganic cation transmembrane transporter activity	Extinctions
LALBI	GO:0030234	enzyme regulator activity	Extinctions
LALBI	GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
LALBI	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
LALBI	GO:0030545	receptor regulator activity	Extinctions
HY41	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY41	GO:0034061	DNA polymerase activity	Gains
HY41	GO:0140097	catalytic activity, acting on DNA	Gains
HY41	GO:0016779	nucleotidyltransferase activity	Gains
HY41	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY41	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY41	GO:0003723	RNA binding	Gains
HY41	GO:0070001	aspartic-type peptidase activity	Gains
HY41	GO:0004190	aspartic-type endopeptidase activity	Gains
HY41	GO:0004519	endonuclease activity	Gains
HY41	GO:0003676	nucleic acid binding	Gains
HY41	GO:0046914	transition metal ion binding	Gains
HY41	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY41	GO:0008270	zinc ion binding	Gains
HY41	GO:0004521	endoribonuclease activity	Gains
HY41	GO:0004518	nuclease activity	Gains
HY41	GO:0016740	transferase activity	Gains
HY41	GO:1901363	heterocyclic compound binding	Gains
HY41	GO:0097159	organic cyclic compound binding	Gains
HY41	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY41	GO:0004540	ribonuclease activity	Gains
HY41	GO:0009008	DNA-methyltransferase activity	Gains
HY41	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
HY41	GO:0140098	catalytic activity, acting on RNA	Gains
HY41	GO:0008812	choline dehydrogenase activity	Gains
HY41	GO:0097747	RNA polymerase activity	Gains
HY41	GO:0034062	5'-3' RNA polymerase activity	Gains
HY41	GO:0022890	inorganic cation transmembrane transporter activity	Gains
HY41	GO:0009055	electron transfer activity	Gains
HY41	GO:0008324	cation transmembrane transporter activity	Gains
HY41	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
HY41	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
HY41	GO:0003677	DNA binding	Gains
HY41	GO:0015078	hydrogen ion transmembrane transporter activity	Gains
HY41	GO:0003824	catalytic activity	Gains
HY41	GO:0004364	glutathione transferase activity	Gains
HY41	GO:0004734	pyrimidodiazepine synthase activity	Gains
HY41	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
HY41	GO:0005043	netrin receptor activity involved in chemorepulsion	Gains
HY41	GO:0060072	large conductance calcium-activated potassium channel activity	Gains
HY41	GO:0070976	TIR domain binding	Gains
HY41	GO:0004055	argininosuccinate synthase activity	Gains
HY41	GO:0004056	argininosuccinate lyase activity	Gains
HY41	GO:0004034	aldose 1-epimerase activity	Gains
HY41	GO:0042768	ecdysteroid 2-hydroxylase activity	Gains
HY41	GO:0042736	NADH kinase activity	Gains
HY41	GO:0015026	coreceptor activity	Gains
HY41	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
HY41	GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
HY41	GO:0043295	glutathione binding	Gains
HY41	GO:1900750	oligopeptide binding	Gains
HY41	GO:0003837	beta-ureidopropionase activity	Gains
HY41	GO:0004170	dUTP diphosphatase activity	Gains
HY41	GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
HY41	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
HY41	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
HY41	GO:0046872	metal ion binding	Gains
HY41	GO:0043169	cation binding	Gains
HY41	GO:0099600	transmembrane receptor activity	Losses
HY41	GO:0004872	receptor activity	Losses
HY41	GO:0004930	G-protein coupled receptor activity	Losses
HY41	GO:0060089	molecular transducer activity	Losses
HY41	GO:0004888	transmembrane signaling receptor activity	Losses
HY41	GO:0038023	signaling receptor activity	Losses
HY41	GO:0004871	signal transducer activity	Losses
HY41	GO:0004984	olfactory receptor activity	Losses
HY41	GO:0005549	odorant binding	Losses
HY41	GO:0008227	G-protein coupled amine receptor activity	Losses
HY41	GO:0008233	peptidase activity	Losses
HY41	GO:0008527	taste receptor activity	Losses
HY41	GO:0005216	ion channel activity	Losses
HY41	GO:0022838	substrate-specific channel activity	Losses
HY41	GO:0015267	channel activity	Losses
HY41	GO:0022803	passive transmembrane transporter activity	Losses
HY41	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
HY41	GO:0004993	G-protein coupled serotonin receptor activity	Losses
HY41	GO:0099589	serotonin receptor activity	Losses
HY41	GO:0008237	metallopeptidase activity	Losses
HY41	GO:0004935	adrenergic receptor activity	Losses
HY41	GO:0015276	ligand-gated ion channel activity	Losses
HY41	GO:0022834	ligand-gated channel activity	Losses
HY41	GO:0022836	gated channel activity	Losses
HY41	GO:0043855	cyclic nucleotide-gated ion channel activity	Losses
HY41	GO:0005000	vasopressin receptor activity	Losses
HY41	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Losses
HY41	GO:0042562	hormone binding	Losses
HY41	GO:0008528	G-protein coupled peptide receptor activity	Losses
HY41	GO:0005261	cation channel activity	Losses
HY41	GO:0001653	peptide receptor activity	Losses
HY41	GO:0005509	calcium ion binding	Losses
HY41	GO:0004867	serine-type endopeptidase inhibitor activity	Losses
HY41	GO:0042834	peptidoglycan binding	Losses
HY41	GO:0016500	protein-hormone receptor activity	Losses
HY41	GO:0004222	metalloendopeptidase activity	Losses
HY41	GO:0022857	transmembrane transporter activity	Losses
HY41	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY41	GO:0008238	exopeptidase activity	Losses
HY41	GO:0004692	cGMP-dependent protein kinase activity	Losses
HY41	GO:0005217	intracellular ligand-gated ion channel activity	Losses
HY41	GO:0008188	neuropeptide receptor activity	Losses
HY41	GO:0005230	extracellular ligand-gated ion channel activity	Losses
HY41	GO:0004175	endopeptidase activity	Losses
HY41	GO:0004629	phospholipase C activity	Losses
HY41	GO:0016801	hydrolase activity, acting on ether bonds	Losses
HY41	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
HY41	GO:0005215	transporter activity	Losses
HY41	GO:0005244	voltage-gated ion channel activity	Losses
HY41	GO:0022832	voltage-gated channel activity	Losses
HY41	GO:0050221	prostaglandin-E2 9-reductase activity	Losses
HY41	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
HY41	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
HY41	GO:0019811	cocaine binding	Losses
HY41	GO:0042943	D-amino acid transmembrane transporter activity	Losses
HY41	GO:0042947	glucoside transmembrane transporter activity	Losses
HY41	GO:0015222	serotonin transmembrane transporter activity	Losses
HY41	GO:0052722	fatty acid in-chain hydroxylase activity	Losses
HY41	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Losses
HY41	GO:0036401	pyrokinin receptor activity	Losses
HY41	GO:0018833	DDT-dehydrochlorinase activity	Losses
HY41	GO:0001587	Gq/11-coupled serotonin receptor activity	Losses
HY41	GO:0005031	tumor necrosis factor-activated receptor activity	Losses
HY41	GO:0005035	death receptor activity	Losses
HY41	GO:0046790	virion binding	Losses
HY41	GO:0015574	trehalose transmembrane transporter activity	Losses
HY41	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
HY41	GO:0004936	alpha-adrenergic receptor activity	Losses
HY41	GO:0004937	alpha1-adrenergic receptor activity	Losses
HY41	GO:0005329	dopamine transmembrane transporter activity	Losses
HY41	GO:0017159	pantetheine hydrolase activity	Losses
HY41	GO:0050353	trimethyllysine dioxygenase activity	Losses
HY41	GO:0050357	tropinesterase activity	Losses
HY41	GO:0042586	peptide deformylase activity	Losses
HY41	GO:0016618	hydroxypyruvate reductase activity	Losses
HY41	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
HY41	GO:0004474	malate synthase activity	Losses
HY41	GO:0045480	galactose oxidase activity	Losses
HY41	GO:0008887	glycerate kinase activity	Losses
HY41	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
HY41	GO:0005326	neurotransmitter transporter activity	Losses
HY41	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
HY41	GO:0017171	serine hydrolase activity	Losses
HY41	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY41	GO:0022891	substrate-specific transmembrane transporter activity	Losses
HY41	GO:0009975	cyclase activity	Losses
HY41	GO:0016849	phosphorus-oxygen lyase activity	Losses
HY41	GO:0004866	endopeptidase inhibitor activity	Losses
HY41	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
HY41	GO:0099600	transmembrane receptor activity	Extinctions
HY41	GO:0004930	G-protein coupled receptor activity	Extinctions
HY41	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY41	GO:0004872	receptor activity	Extinctions
HY41	GO:0060089	molecular transducer activity	Extinctions
HY41	GO:0038023	signaling receptor activity	Extinctions
HY41	GO:0004871	signal transducer activity	Extinctions
HY41	GO:0005549	odorant binding	Extinctions
HY41	GO:0004984	olfactory receptor activity	Extinctions
HY41	GO:0008336	gamma-butyrobetaine dioxygenase activity	Extinctions
HY41	GO:0043855	cyclic nucleotide-gated ion channel activity	Extinctions
HY41	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Extinctions
HY41	GO:0005216	ion channel activity	Extinctions
HY41	GO:0022838	substrate-specific channel activity	Extinctions
HY41	GO:0015267	channel activity	Extinctions
HY41	GO:0022803	passive transmembrane transporter activity	Extinctions
HY41	GO:0015276	ligand-gated ion channel activity	Extinctions
HY41	GO:0022834	ligand-gated channel activity	Extinctions
HY41	GO:0008227	G-protein coupled amine receptor activity	Extinctions
HY41	GO:0008527	taste receptor activity	Extinctions
HY41	GO:0004692	cGMP-dependent protein kinase activity	Extinctions
HY41	GO:0005217	intracellular ligand-gated ion channel activity	Extinctions
HY41	GO:0004935	adrenergic receptor activity	Extinctions
HY41	GO:0022836	gated channel activity	Extinctions
HY41	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Extinctions
HY41	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
HY41	GO:0050221	prostaglandin-E2 9-reductase activity	Extinctions
HY41	GO:0052722	fatty acid in-chain hydroxylase activity	Extinctions
HY41	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Extinctions
HY41	GO:0001587	Gq/11-coupled serotonin receptor activity	Extinctions
HY41	GO:0005031	tumor necrosis factor-activated receptor activity	Extinctions
HY41	GO:0005035	death receptor activity	Extinctions
HY41	GO:0004936	alpha-adrenergic receptor activity	Extinctions
HY41	GO:0004937	alpha1-adrenergic receptor activity	Extinctions
HY41	GO:0050353	trimethyllysine dioxygenase activity	Extinctions
HY41	GO:0042586	peptide deformylase activity	Extinctions
HY41	GO:0045480	galactose oxidase activity	Extinctions
HY41	GO:0005261	cation channel activity	Extinctions
HY41	GO:0004383	guanylate cyclase activity	Extinctions
HY41	GO:0005509	calcium ion binding	Extinctions
HY41	GO:0003938	IMP dehydrogenase activity	Extinctions
HY41	GO:0008422	beta-glucosidase activity	Extinctions
HY41	GO:0005222	intracellular cAMP activated cation channel activity	Extinctions
HY41	GO:0005223	intracellular cGMP activated cation channel activity	Extinctions
CQUIN	GO:0003964	RNA-directed DNA polymerase activity	Gains
CQUIN	GO:0034061	DNA polymerase activity	Gains
CQUIN	GO:0099600	transmembrane receptor activity	Gains
CQUIN	GO:0005549	odorant binding	Gains
CQUIN	GO:0004984	olfactory receptor activity	Gains
CQUIN	GO:0140097	catalytic activity, acting on DNA	Gains
CQUIN	GO:0038023	signaling receptor activity	Gains
CQUIN	GO:0004872	receptor activity	Gains
CQUIN	GO:0004888	transmembrane signaling receptor activity	Gains
CQUIN	GO:0060089	molecular transducer activity	Gains
CQUIN	GO:0004871	signal transducer activity	Gains
CQUIN	GO:0004930	G-protein coupled receptor activity	Gains
CQUIN	GO:0016779	nucleotidyltransferase activity	Gains
CQUIN	GO:0008527	taste receptor activity	Gains
CQUIN	GO:0022834	ligand-gated channel activity	Gains
CQUIN	GO:0015276	ligand-gated ion channel activity	Gains
CQUIN	GO:0038187	pattern recognition receptor activity	Gains
CQUIN	GO:0008329	signaling pattern recognition receptor activity	Gains
CQUIN	GO:0005216	ion channel activity	Gains
CQUIN	GO:0022838	substrate-specific channel activity	Gains
CQUIN	GO:0022803	passive transmembrane transporter activity	Gains
CQUIN	GO:0015267	channel activity	Gains
CQUIN	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
CQUIN	GO:0022836	gated channel activity	Gains
CQUIN	GO:0004971	AMPA glutamate receptor activity	Gains
CQUIN	GO:0004866	endopeptidase inhibitor activity	Gains
CQUIN	GO:0070330	aromatase activity	Gains
CQUIN	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
CQUIN	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
CQUIN	GO:0017171	serine hydrolase activity	Gains
CQUIN	GO:0099094	ligand-gated cation channel activity	Gains
CQUIN	GO:0005506	iron ion binding	Gains
CQUIN	GO:0008236	serine-type peptidase activity	Gains
CQUIN	GO:0030414	peptidase inhibitor activity	Gains
CQUIN	GO:0004252	serine-type endopeptidase activity	Gains
CQUIN	GO:0005230	extracellular ligand-gated ion channel activity	Gains
CQUIN	GO:0061135	endopeptidase regulator activity	Gains
CQUIN	GO:0001085	RNA polymerase II transcription factor binding	Gains
CQUIN	GO:0003677	DNA binding	Gains
CQUIN	GO:0022824	transmitter-gated ion channel activity	Gains
CQUIN	GO:0022835	transmitter-gated channel activity	Gains
CQUIN	GO:0004970	ionotropic glutamate receptor activity	Gains
CQUIN	GO:0004707	MAP kinase activity	Gains
CQUIN	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
CQUIN	GO:0046914	transition metal ion binding	Gains
CQUIN	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
CQUIN	GO:0030246	carbohydrate binding	Gains
CQUIN	GO:0030594	neurotransmitter receptor activity	Gains
CQUIN	GO:0004144	diacylglycerol O-acyltransferase activity	Gains
CQUIN	GO:0004736	pyruvate carboxylase activity	Gains
CQUIN	GO:0004989	octopamine receptor activity	Gains
CQUIN	GO:0043169	cation binding	Gains
CQUIN	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
CQUIN	GO:0046872	metal ion binding	Gains
CQUIN	GO:0008066	glutamate receptor activity	Gains
CQUIN	GO:0015645	fatty acid ligase activity	Gains
CQUIN	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
CQUIN	GO:0001871	pattern binding	Gains
CQUIN	GO:0030247	polysaccharide binding	Gains
CQUIN	GO:0004518	nuclease activity	Gains
CQUIN	GO:0018685	alkane 1-monooxygenase activity	Gains
CQUIN	GO:0008521	acetyl-CoA transporter activity	Gains
CQUIN	GO:1990050	phosphatidic acid transporter activity	Gains
CQUIN	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	Gains
CQUIN	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	Gains
CQUIN	GO:0001872	(1->3)-beta-D-glucan binding	Gains
CQUIN	GO:0016848	carbon-halide lyase activity	Gains
CQUIN	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
CQUIN	GO:0004644	phosphoribosylglycinamide formyltransferase activity	Gains
CQUIN	GO:0001607	neuromedin U receptor activity	Gains
CQUIN	GO:0001092	TFIIA-class transcription factor binding	Gains
CQUIN	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
CQUIN	GO:0004415	hyalurononglucosaminidase activity	Gains
CQUIN	GO:0042277	peptide binding	Losses
CQUIN	GO:0033218	amide binding	Losses
CQUIN	GO:0008613	diuretic hormone activity	Losses
CQUIN	GO:0017046	peptide hormone binding	Losses
CQUIN	GO:0005509	calcium ion binding	Losses
CQUIN	GO:0005184	neuropeptide hormone activity	Losses
CQUIN	GO:0004872	receptor activity	Losses
CQUIN	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
CQUIN	GO:0019894	kinesin binding	Losses
CQUIN	GO:0019199	transmembrane receptor protein kinase activity	Losses
CQUIN	GO:0098772	molecular function regulator	Losses
CQUIN	GO:0005179	hormone activity	Losses
CQUIN	GO:0016835	carbon-oxygen lyase activity	Losses
CQUIN	GO:0060089	molecular transducer activity	Losses
CQUIN	GO:0004888	transmembrane signaling receptor activity	Losses
CQUIN	GO:0004620	phospholipase activity	Losses
CQUIN	GO:0016788	hydrolase activity, acting on ester bonds	Losses
CQUIN	GO:0099600	transmembrane receptor activity	Losses
CQUIN	GO:0032947	protein complex scaffold activity	Losses
CQUIN	GO:0008252	nucleotidase activity	Losses
CQUIN	GO:0003964	RNA-directed DNA polymerase activity	Losses
CQUIN	GO:0004623	phospholipase A2 activity	Losses
CQUIN	GO:0004089	carbonate dehydratase activity	Losses
CQUIN	GO:0038023	signaling receptor activity	Losses
CQUIN	GO:0042578	phosphoric ester hydrolase activity	Losses
CQUIN	GO:0016836	hydro-lyase activity	Losses
CQUIN	GO:0016779	nucleotidyltransferase activity	Losses
CQUIN	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
CQUIN	GO:0048018	receptor ligand activity	Losses
CQUIN	GO:0016298	lipase activity	Losses
CQUIN	GO:0034061	DNA polymerase activity	Losses
CQUIN	GO:0008878	glucose-1-phosphate adenylyltransferase activity	Losses
CQUIN	GO:0016157	sucrose synthase activity	Losses
CQUIN	GO:0035013	myosuppressin receptor activity	Losses
CQUIN	GO:0001222	transcription corepressor binding	Losses
CQUIN	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
CQUIN	GO:0033164	glycolipid 6-alpha-mannosyltransferase activity	Losses
CQUIN	GO:0051425	PTB domain binding	Losses
CQUIN	GO:0008073	ornithine decarboxylase inhibitor activity	Losses
CQUIN	GO:0071861	tachykinin receptor binding	Losses
CQUIN	GO:0004642	phosphoribosylformylglycinamidine synthase activity	Losses
CQUIN	GO:0008929	methylglyoxal synthase activity	Losses
CQUIN	GO:0061778	intracellular chloride channel activity	Losses
CQUIN	GO:0005009	insulin-activated receptor activity	Losses
CQUIN	GO:0043560	insulin receptor substrate binding	Losses
CQUIN	GO:0043559	insulin binding	Losses
CQUIN	GO:0042979	ornithine decarboxylase regulator activity	Losses
CQUIN	GO:0004099	chitin deacetylase activity	Losses
CQUIN	GO:0031370	eukaryotic initiation factor 4G binding	Losses
CQUIN	GO:0047964	glyoxylate reductase activity	Losses
CQUIN	GO:0031473	myosin III binding	Losses
CQUIN	GO:0016034	maleylacetoacetate isomerase activity	Losses
CQUIN	GO:0008196	vitellogenin receptor activity	Losses
CQUIN	GO:0004376	glycolipid mannosyltransferase activity	Losses
CQUIN	GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	Losses
CQUIN	GO:0015277	kainate selective glutamate receptor activity	Losses
CQUIN	GO:0042165	neurotransmitter binding	Losses
CQUIN	GO:0042166	acetylcholine binding	Losses
CQUIN	GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Losses
CQUIN	GO:0030267	glyoxylate reductase (NADP) activity	Losses
CQUIN	GO:0005229	intracellular calcium activated chloride channel activity	Losses
CQUIN	GO:0016499	orexin receptor activity	Losses
CQUIN	GO:0004153	dihydropterin deaminase activity	Losses
CQUIN	GO:0071855	neuropeptide receptor binding	Losses
CQUIN	GO:0015171	amino acid transmembrane transporter activity	Losses
CQUIN	GO:0030234	enzyme regulator activity	Losses
CQUIN	GO:0030545	receptor regulator activity	Losses
CQUIN	GO:0017022	myosin binding	Losses
CQUIN	GO:0038024	cargo receptor activity	Losses
CQUIN	GO:0008081	phosphoric diester hydrolase activity	Losses
CQUIN	GO:0042562	hormone binding	Losses
CQUIN	GO:0004857	enzyme inhibitor activity	Losses
CQUIN	GO:0004871	signal transducer activity	Losses
CQUIN	GO:0052689	carboxylic ester hydrolase activity	Losses
CQUIN	GO:0005184	neuropeptide hormone activity	Extinctions
CQUIN	GO:0008613	diuretic hormone activity	Extinctions
CQUIN	GO:0005179	hormone activity	Extinctions
CQUIN	GO:0019894	kinesin binding	Extinctions
CQUIN	GO:0098772	molecular function regulator	Extinctions
CQUIN	GO:0004623	phospholipase A2 activity	Extinctions
CQUIN	GO:0032947	protein complex scaffold activity	Extinctions
CQUIN	GO:0048018	receptor ligand activity	Extinctions
CQUIN	GO:0052689	carboxylic ester hydrolase activity	Extinctions
CQUIN	GO:0030545	receptor regulator activity	Extinctions
CQUIN	GO:0017022	myosin binding	Extinctions
CQUIN	GO:0004857	enzyme inhibitor activity	Extinctions
CQUIN	GO:0016835	carbon-oxygen lyase activity	Extinctions
CQUIN	GO:0071855	neuropeptide receptor binding	Extinctions
CQUIN	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
CQUIN	GO:0008878	glucose-1-phosphate adenylyltransferase activity	Extinctions
CQUIN	GO:0016157	sucrose synthase activity	Extinctions
CQUIN	GO:0033164	glycolipid 6-alpha-mannosyltransferase activity	Extinctions
CQUIN	GO:0051425	PTB domain binding	Extinctions
CQUIN	GO:0008073	ornithine decarboxylase inhibitor activity	Extinctions
CQUIN	GO:0071861	tachykinin receptor binding	Extinctions
CQUIN	GO:0004642	phosphoribosylformylglycinamidine synthase activity	Extinctions
CQUIN	GO:0008929	methylglyoxal synthase activity	Extinctions
CQUIN	GO:0005009	insulin-activated receptor activity	Extinctions
CQUIN	GO:0043560	insulin receptor substrate binding	Extinctions
CQUIN	GO:0043559	insulin binding	Extinctions
CQUIN	GO:0042979	ornithine decarboxylase regulator activity	Extinctions
CQUIN	GO:0031370	eukaryotic initiation factor 4G binding	Extinctions
CQUIN	GO:0031473	myosin III binding	Extinctions
CQUIN	GO:0016034	maleylacetoacetate isomerase activity	Extinctions
CQUIN	GO:0008196	vitellogenin receptor activity	Extinctions
CQUIN	GO:0004376	glycolipid mannosyltransferase activity	Extinctions
CQUIN	GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	Extinctions
CQUIN	GO:0050518	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	Extinctions
CQUIN	GO:0004153	dihydropterin deaminase activity	Extinctions
CQUIN	GO:0001664	G-protein coupled receptor binding	Extinctions
CQUIN	GO:0042826	histone deacetylase binding	Extinctions
CQUIN	GO:0005096	GTPase activator activity	Extinctions
CQUIN	GO:0016307	phosphatidylinositol phosphate kinase activity	Extinctions
HY43	GO:0004970	ionotropic glutamate receptor activity	Gains
HY43	GO:0022824	transmitter-gated ion channel activity	Gains
HY43	GO:0022835	transmitter-gated channel activity	Gains
HY43	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
HY43	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
HY43	GO:0099600	transmembrane receptor activity	Gains
HY43	GO:0008066	glutamate receptor activity	Gains
HY43	GO:0005230	extracellular ligand-gated ion channel activity	Gains
HY43	GO:0004888	transmembrane signaling receptor activity	Gains
HY43	GO:0030594	neurotransmitter receptor activity	Gains
HY43	GO:0005549	odorant binding	Gains
HY43	GO:0022834	ligand-gated channel activity	Gains
HY43	GO:0015276	ligand-gated ion channel activity	Gains
HY43	GO:0038023	signaling receptor activity	Gains
HY43	GO:0015075	ion transmembrane transporter activity	Gains
HY43	GO:0022857	transmembrane transporter activity	Gains
HY43	GO:0004984	olfactory receptor activity	Gains
HY43	GO:0004872	receptor activity	Gains
HY43	GO:0022891	substrate-specific transmembrane transporter activity	Gains
HY43	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY43	GO:0004930	G-protein coupled receptor activity	Gains
HY43	GO:0060089	molecular transducer activity	Gains
HY43	GO:0005216	ion channel activity	Gains
HY43	GO:0008172	S-methyltransferase activity	Gains
HY43	GO:0022838	substrate-specific channel activity	Gains
HY43	GO:0022836	gated channel activity	Gains
HY43	GO:0034061	DNA polymerase activity	Gains
HY43	GO:0009055	electron transfer activity	Gains
HY43	GO:0022803	passive transmembrane transporter activity	Gains
HY43	GO:0015267	channel activity	Gains
HY43	GO:0022892	substrate-specific transporter activity	Gains
HY43	GO:0140097	catalytic activity, acting on DNA	Gains
HY43	GO:0016779	nucleotidyltransferase activity	Gains
HY43	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
HY43	GO:0004871	signal transducer activity	Gains
HY43	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
HY43	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
HY43	GO:0070001	aspartic-type peptidase activity	Gains
HY43	GO:0004190	aspartic-type endopeptidase activity	Gains
HY43	GO:0030246	carbohydrate binding	Gains
HY43	GO:0004587	ornithine-oxo-acid transaminase activity	Gains
HY43	GO:0000700	mismatch base pair DNA N-glycosylase activity	Gains
HY43	GO:0001614	purinergic nucleotide receptor activity	Gains
HY43	GO:0050897	cobalt ion binding	Gains
HY43	GO:0004020	adenylylsulfate kinase activity	Gains
HY43	GO:0004038	allantoinase activity	Gains
HY43	GO:0005368	taurine transmembrane transporter activity	Gains
HY43	GO:0005369	taurine:sodium symporter activity	Gains
HY43	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
HY43	GO:0016502	nucleotide receptor activity	Gains
HY43	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Gains
HY43	GO:0008255	ecdysis-triggering hormone activity	Gains
HY43	GO:0004301	epoxide hydrolase activity	Gains
HY43	GO:0019153	protein-disulfide reductase (glutathione) activity	Gains
HY43	GO:0004459	L-lactate dehydrogenase activity	Gains
HY43	GO:0008810	cellulase activity	Gains
HY43	GO:0034584	piRNA binding	Gains
HY43	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
HY43	GO:0022890	inorganic cation transmembrane transporter activity	Gains
HY43	GO:0005215	transporter activity	Gains
HY43	GO:0015002	heme-copper terminal oxidase activity	Gains
HY43	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
HY43	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
HY43	GO:0004129	cytochrome-c oxidase activity	Gains
HY43	GO:0015078	hydrogen ion transmembrane transporter activity	Gains
HY43	GO:0008020	G-protein coupled photoreceptor activity	Gains
HY43	GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Gains
HY43	GO:0015501	glutamate:sodium symporter activity	Gains
HY43	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
HY43	GO:0050591	quinine 3-monooxygenase activity	Gains
HY43	GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
HY43	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HY43	GO:0031386	protein tag	Gains
HY43	GO:0008273	calcium, potassium:sodium antiporter activity	Gains
HY43	GO:0004457	lactate dehydrogenase activity	Gains
HY43	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
HY43	GO:0016992	lipoate synthase activity	Gains
HY43	GO:0070283	radical SAM enzyme activity	Gains
HY43	GO:0016979	lipoate-protein ligase activity	Gains
HY43	GO:0035586	purinergic receptor activity	Gains
HY43	GO:0015183	L-aspartate transmembrane transporter activity	Gains
HY43	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
HY43	GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
HY43	GO:0070888	E-box binding	Gains
HY43	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
HY43	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY43	GO:0034061	DNA polymerase activity	Losses
HY43	GO:0005215	transporter activity	Losses
HY43	GO:0140097	catalytic activity, acting on DNA	Losses
HY43	GO:0003990	acetylcholinesterase activity	Losses
HY43	GO:0004104	cholinesterase activity	Losses
HY43	GO:0022857	transmembrane transporter activity	Losses
HY43	GO:0016779	nucleotidyltransferase activity	Losses
HY43	GO:0004803	transposase activity	Losses
HY43	GO:0070001	aspartic-type peptidase activity	Losses
HY43	GO:0004190	aspartic-type endopeptidase activity	Losses
HY43	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
HY43	GO:0022804	active transmembrane transporter activity	Losses
HY43	GO:0071855	neuropeptide receptor binding	Losses
HY43	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
HY43	GO:0015075	ion transmembrane transporter activity	Losses
HY43	GO:0008301	DNA binding, bending	Losses
HY43	GO:0022853	active ion transmembrane transporter activity	Losses
HY43	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
HY43	GO:0043492	ATPase activity, coupled to movement of substances	Losses
HY43	GO:0022891	substrate-specific transmembrane transporter activity	Losses
HY43	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
HY43	GO:0015399	primary active transmembrane transporter activity	Losses
HY43	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
HY43	GO:0008408	3'-5' exonuclease activity	Losses
HY43	GO:0015604	organic phosphonate transmembrane transporter activity	Losses
HY43	GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Losses
HY43	GO:0022892	substrate-specific transporter activity	Losses
HY43	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
HY43	GO:0004846	urate oxidase activity	Losses
HY43	GO:0050221	prostaglandin-E2 9-reductase activity	Losses
HY43	GO:0050232	putrescine oxidase activity	Losses
HY43	GO:0015574	trehalose transmembrane transporter activity	Losses
HY43	GO:0042654	ecdysis-triggering hormone receptor activity	Losses
HY43	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
HY43	GO:0004062	aryl sulfotransferase activity	Losses
HY43	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Losses
HY43	GO:0004027	alcohol sulfotransferase activity	Losses
HY43	GO:0004046	aminoacylase activity	Losses
HY43	GO:0047617	acyl-CoA hydrolase activity	Losses
HY43	GO:0032542	sulfiredoxin activity	Losses
HY43	GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
HY43	GO:0008473	ornithine cyclodeaminase activity	Losses
HY43	GO:0042947	glucoside transmembrane transporter activity	Losses
HY43	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Losses
HY43	GO:0000036	acyl carrier activity	Losses
HY43	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
HY43	GO:0047964	glyoxylate reductase activity	Losses
HY43	GO:0005436	sodium:phosphate symporter activity	Losses
HY43	GO:0035274	diphenyl phthalate binding	Losses
HY43	GO:0035275	dibutyl phthalate binding	Losses
HY43	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
HY43	GO:0004304	estrone sulfotransferase activity	Losses
HY43	GO:0003839	gamma-glutamylcyclotransferase activity	Losses
HY43	GO:0031177	phosphopantetheine binding	Losses
HY43	GO:0005225	volume-sensitive anion channel activity	Losses
HY43	GO:0072320	volume-sensitive chloride channel activity	Losses
HY43	GO:0004139	deoxyribose-phosphate aldolase activity	Losses
HY43	GO:0015438	teichoic-acid-transporting ATPase activity	Losses
HY43	GO:0036132	13-prostaglandin reductase activity	Losses
HY43	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Losses
HY43	GO:0015162	teichoic acid transmembrane transporter activity	Losses
HY43	GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
HY43	GO:0044620	ACP phosphopantetheine attachment site binding	Losses
HY43	GO:0004796	thromboxane-A synthase activity	Losses
HY43	GO:0030267	glyoxylate reductase (NADP) activity	Losses
HY43	GO:0004747	ribokinase activity	Losses
HY43	GO:0051192	prosthetic group binding	Losses
HY43	GO:0018738	S-formylglutathione hydrolase activity	Losses
HY43	GO:0042625	ATPase coupled ion transmembrane transporter activity	Losses
HY43	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
HY43	GO:0003676	nucleic acid binding	Losses
HY43	GO:0022890	inorganic cation transmembrane transporter activity	Losses
HY43	GO:0005549	odorant binding	Losses
HY43	GO:0008270	zinc ion binding	Losses
HY43	GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
HY43	GO:0051287	NAD binding	Losses
HY43	GO:0015293	symporter activity	Losses
HY43	GO:0008324	cation transmembrane transporter activity	Losses
HY43	GO:0031490	chromatin DNA binding	Losses
HY43	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
HY43	GO:0071855	neuropeptide receptor binding	Extinctions
HY43	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
HY43	GO:0005549	odorant binding	Extinctions
HY43	GO:0004846	urate oxidase activity	Extinctions
HY43	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
HY43	GO:0004062	aryl sulfotransferase activity	Extinctions
HY43	GO:0004027	alcohol sulfotransferase activity	Extinctions
HY43	GO:0047617	acyl-CoA hydrolase activity	Extinctions
HY43	GO:0032542	sulfiredoxin activity	Extinctions
HY43	GO:0008473	ornithine cyclodeaminase activity	Extinctions
HY43	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
HY43	GO:0000036	acyl carrier activity	Extinctions
HY43	GO:0035274	diphenyl phthalate binding	Extinctions
HY43	GO:0035275	dibutyl phthalate binding	Extinctions
HY43	GO:0004304	estrone sulfotransferase activity	Extinctions
HY43	GO:0003839	gamma-glutamylcyclotransferase activity	Extinctions
HY43	GO:0031177	phosphopantetheine binding	Extinctions
HY43	GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
HY43	GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
HY43	GO:0036132	13-prostaglandin reductase activity	Extinctions
HY43	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Extinctions
HY43	GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
HY43	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
HY43	GO:0004747	ribokinase activity	Extinctions
HY43	GO:0051192	prosthetic group binding	Extinctions
HY43	GO:0042625	ATPase coupled ion transmembrane transporter activity	Extinctions
HY43	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
HY43	GO:0008408	3'-5' exonuclease activity	Extinctions
HY43	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
HY43	GO:0034061	DNA polymerase activity	Extinctions
HY43	GO:0005184	neuropeptide hormone activity	Extinctions
HY43	GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
HY43	GO:0008020	G-protein coupled photoreceptor activity	Extinctions
HY43	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
HY43	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
HY43	GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
HY43	GO:0016841	ammonia-lyase activity	Extinctions
HY43	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Extinctions
HY43	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
HY43	GO:0004496	mevalonate kinase activity	Extinctions
HY43	GO:0016084	myostimulatory hormone activity	Extinctions
HY43	GO:0043958	acryloyl-CoA reductase activity	Extinctions
HY43	GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
HY43	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
HY43	GO:0008526	phosphatidylinositol transporter activity	Extinctions
HY43	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
HY43	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	Extinctions
HY43	GO:0005550	pheromone binding	Extinctions
HY43	GO:0047134	protein-disulfide reductase activity	Extinctions
HY43	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
HY43	GO:0008301	DNA binding, bending	Extinctions
HY43	GO:0022853	active ion transmembrane transporter activity	Extinctions
HY43	GO:0005215	transporter activity	Extinctions
HY43	GO:0005179	hormone activity	Extinctions
HY43	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
HY43	GO:0004532	exoribonuclease activity	Extinctions
HY43	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
APISU	GO:0003676	nucleic acid binding	Gains
APISU	GO:0003964	RNA-directed DNA polymerase activity	Gains
APISU	GO:0034061	DNA polymerase activity	Gains
APISU	GO:1901363	heterocyclic compound binding	Gains
APISU	GO:0097159	organic cyclic compound binding	Gains
APISU	GO:0140097	catalytic activity, acting on DNA	Gains
APISU	GO:0016779	nucleotidyltransferase activity	Gains
APISU	GO:0008270	zinc ion binding	Gains
APISU	GO:0046914	transition metal ion binding	Gains
APISU	GO:0004190	aspartic-type endopeptidase activity	Gains
APISU	GO:0070001	aspartic-type peptidase activity	Gains
APISU	GO:0003677	DNA binding	Gains
APISU	GO:0004984	olfactory receptor activity	Gains
APISU	GO:0005549	odorant binding	Gains
APISU	GO:0005488	binding	Gains
APISU	GO:0000156	phosphorelay response regulator activity	Gains
APISU	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
APISU	GO:0003723	RNA binding	Gains
APISU	GO:0004175	endopeptidase activity	Gains
APISU	GO:0003678	DNA helicase activity	Gains
APISU	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
APISU	GO:0034062	5'-3' RNA polymerase activity	Gains
APISU	GO:0097747	RNA polymerase activity	Gains
APISU	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
APISU	GO:0004803	transposase activity	Gains
APISU	GO:0008527	taste receptor activity	Gains
APISU	GO:0005351	sugar:proton symporter activity	Gains
APISU	GO:0005402	cation:sugar symporter activity	Gains
APISU	GO:0015295	solute:proton symporter activity	Gains
APISU	GO:0003682	chromatin binding	Gains
APISU	GO:0043169	cation binding	Gains
APISU	GO:0015144	carbohydrate transmembrane transporter activity	Gains
APISU	GO:0015927	trehalase activity	Gains
APISU	GO:0004555	alpha,alpha-trehalase activity	Gains
APISU	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
APISU	GO:0046872	metal ion binding	Gains
APISU	GO:0004518	nuclease activity	Gains
APISU	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
APISU	GO:0019842	vitamin binding	Gains
APISU	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
APISU	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
APISU	GO:0004758	serine C-palmitoyltransferase activity	Gains
APISU	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
APISU	GO:0033041	sweet taste receptor activity	Gains
APISU	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
APISU	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Gains
APISU	GO:0017056	structural constituent of nuclear pore	Gains
APISU	GO:0016454	C-palmitoyltransferase activity	Gains
APISU	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Gains
APISU	GO:0003796	lysozyme activity	Gains
APISU	GO:0030976	thiamine pyrophosphate binding	Gains
APISU	GO:0004835	tubulin-tyrosine ligase activity	Gains
APISU	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Gains
APISU	GO:0009008	DNA-methyltransferase activity	Gains
APISU	GO:0051119	sugar transmembrane transporter activity	Gains
APISU	GO:0061783	peptidoglycan muralytic activity	Gains
APISU	GO:0000155	phosphorelay sensor kinase activity	Gains
APISU	GO:0004673	protein histidine kinase activity	Gains
APISU	GO:0004386	helicase activity	Gains
APISU	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
APISU	GO:0048037	cofactor binding	Gains
APISU	GO:0017016	Ras GTPase binding	Losses
APISU	GO:0031267	small GTPase binding	Losses
APISU	GO:0051020	GTPase binding	Losses
APISU	GO:0019899	enzyme binding	Losses
APISU	GO:0017137	Rab GTPase binding	Losses
APISU	GO:0004672	protein kinase activity	Losses
APISU	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
APISU	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
APISU	GO:0022843	voltage-gated cation channel activity	Losses
APISU	GO:0016301	kinase activity	Losses
APISU	GO:0022836	gated channel activity	Losses
APISU	GO:0004872	receptor activity	Losses
APISU	GO:0046873	metal ion transmembrane transporter activity	Losses
APISU	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
APISU	GO:0060089	molecular transducer activity	Losses
APISU	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
APISU	GO:0005244	voltage-gated ion channel activity	Losses
APISU	GO:0022832	voltage-gated channel activity	Losses
APISU	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
APISU	GO:0017048	Rho GTPase binding	Losses
APISU	GO:0005249	voltage-gated potassium channel activity	Losses
APISU	GO:0140096	catalytic activity, acting on a protein	Losses
APISU	GO:0004871	signal transducer activity	Losses
APISU	GO:0019199	transmembrane receptor protein kinase activity	Losses
APISU	GO:0004713	protein tyrosine kinase activity	Losses
APISU	GO:0099516	ion antiporter activity	Losses
APISU	GO:0005261	cation channel activity	Losses
APISU	GO:0005452	inorganic anion exchanger activity	Losses
APISU	GO:0042043	neurexin family protein binding	Losses
APISU	GO:0008146	sulfotransferase activity	Losses
APISU	GO:0005267	potassium channel activity	Losses
APISU	GO:0099600	transmembrane receptor activity	Losses
APISU	GO:0046872	metal ion binding	Losses
APISU	GO:0015079	potassium ion transmembrane transporter activity	Losses
APISU	GO:0043169	cation binding	Losses
APISU	GO:0015491	cation:cation antiporter activity	Losses
APISU	GO:0016917	GABA receptor activity	Losses
APISU	GO:0032033	myosin II light chain binding	Losses
APISU	GO:0016906	sterol 3-beta-glucosyltransferase activity	Losses
APISU	GO:0005216	ion channel activity	Losses
APISU	GO:0038023	signaling receptor activity	Losses
APISU	GO:0022838	substrate-specific channel activity	Losses
APISU	GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
APISU	GO:0015297	antiporter activity	Losses
APISU	GO:0016905	myosin heavy chain kinase activity	Losses
APISU	GO:0015085	calcium ion transmembrane transporter activity	Losses
APISU	GO:0008239	dipeptidyl-peptidase activity	Losses
APISU	GO:0005217	intracellular ligand-gated ion channel activity	Losses
APISU	GO:0004888	transmembrane signaling receptor activity	Losses
APISU	GO:0022803	passive transmembrane transporter activity	Losses
APISU	GO:0015267	channel activity	Losses
APISU	GO:0008408	3'-5' exonuclease activity	Losses
APISU	GO:0046906	tetrapyrrole binding	Losses
APISU	GO:0005509	calcium ion binding	Losses
APISU	GO:0015298	solute:cation antiporter activity	Losses
APISU	GO:0015291	secondary active transmembrane transporter activity	Losses
APISU	GO:0004965	G-protein coupled GABA receptor activity	Losses
APISU	GO:0004674	protein serine/threonine kinase activity	Losses
APISU	GO:0043167	ion binding	Losses
APISU	GO:0004683	calmodulin-dependent protein kinase activity	Losses
APISU	GO:0043565	sequence-specific DNA binding	Losses
APISU	GO:0016406	carnitine O-acyltransferase activity	Losses
APISU	GO:0099604	ligand-gated calcium channel activity	Losses
APISU	GO:0016841	ammonia-lyase activity	Losses
APISU	GO:0005501	retinoid binding	Losses
APISU	GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
APISU	GO:0015278	calcium-release channel activity	Losses
APISU	GO:0045159	myosin II binding	Losses
APISU	GO:0098772	molecular function regulator	Losses
APISU	GO:0015075	ion transmembrane transporter activity	Losses
APISU	GO:0020037	heme binding	Losses
APISU	GO:0005245	voltage-gated calcium channel activity	Losses
APISU	GO:0005515	protein binding	Losses
APISU	GO:0022891	substrate-specific transmembrane transporter activity	Losses
APISU	GO:0004842	ubiquitin-protein transferase activity	Losses
APISU	GO:0016782	transferase activity, transferring sulfur-containing groups	Losses
APISU	GO:0008324	cation transmembrane transporter activity	Losses
APISU	GO:0019787	ubiquitin-like protein transferase activity	Losses
APISU	GO:0022890	inorganic cation transmembrane transporter activity	Losses
APISU	GO:0003700	DNA binding transcription factor activity	Losses
APISU	GO:0042302	structural constituent of cuticle	Losses
APISU	GO:0030695	GTPase regulator activity	Losses
APISU	GO:0022834	ligand-gated channel activity	Losses
APISU	GO:0015276	ligand-gated ion channel activity	Losses
APISU	GO:0140110	transcription regulator activity	Losses
APISU	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Losses
APISU	GO:0016597	amino acid binding	Losses
APISU	GO:0004322	ferroxidase activity	Losses
APISU	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
APISU	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Losses
APISU	GO:0070008	serine-type exopeptidase activity	Losses
APISU	GO:0015385	sodium:proton antiporter activity	Losses
APISU	GO:0005201	extracellular matrix structural constituent	Losses
APISU	GO:0099516	ion antiporter activity	Extinctions
APISU	GO:0015491	cation:cation antiporter activity	Extinctions
APISU	GO:0015297	antiporter activity	Extinctions
APISU	GO:0017016	Ras GTPase binding	Extinctions
APISU	GO:0031267	small GTPase binding	Extinctions
APISU	GO:0017137	Rab GTPase binding	Extinctions
APISU	GO:0015298	solute:cation antiporter activity	Extinctions
APISU	GO:0051020	GTPase binding	Extinctions
APISU	GO:0043169	cation binding	Extinctions
APISU	GO:0033961	cis-stilbene-oxide hydrolase activity	Extinctions
APISU	GO:0046872	metal ion binding	Extinctions
APISU	GO:0016917	GABA receptor activity	Extinctions
APISU	GO:0008199	ferric iron binding	Extinctions
APISU	GO:0005452	inorganic anion exchanger activity	Extinctions
APISU	GO:0015385	sodium:proton antiporter activity	Extinctions
APISU	GO:0004713	protein tyrosine kinase activity	Extinctions
APISU	GO:0008146	sulfotransferase activity	Extinctions
APISU	GO:0005451	monovalent cation:proton antiporter activity	Extinctions
APISU	GO:0015368	calcium:cation antiporter activity	Extinctions
APISU	GO:0030145	manganese ion binding	Extinctions
APISU	GO:0019899	enzyme binding	Extinctions
APISU	GO:0008239	dipeptidyl-peptidase activity	Extinctions
APISU	GO:0016803	ether hydrolase activity	Extinctions
APISU	GO:0046914	transition metal ion binding	Extinctions
APISU	GO:0015291	secondary active transmembrane transporter activity	Extinctions
APISU	GO:0004252	serine-type endopeptidase activity	Extinctions
LLONG	GO:0004161	dimethylallyltranstransferase activity	Gains
LLONG	GO:0004659	prenyltransferase activity	Gains
LLONG	GO:0003676	nucleic acid binding	Gains
LLONG	GO:0034061	DNA polymerase activity	Gains
LLONG	GO:1901363	heterocyclic compound binding	Gains
LLONG	GO:0003964	RNA-directed DNA polymerase activity	Gains
LLONG	GO:0097159	organic cyclic compound binding	Gains
LLONG	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
LLONG	GO:0008381	mechanically-gated ion channel activity	Gains
LLONG	GO:0008384	IkappaB kinase activity	Gains
LLONG	GO:0004337	geranyltranstransferase activity	Gains
LLONG	GO:0022833	mechanically gated channel activity	Gains
LLONG	GO:0008061	chitin binding	Gains
LLONG	GO:0004713	protein tyrosine kinase activity	Gains
LLONG	GO:0043167	ion binding	Gains
LLONG	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
LLONG	GO:0016758	transferase activity, transferring hexosyl groups	Gains
LLONG	GO:0043169	cation binding	Gains
LLONG	GO:0004497	monooxygenase activity	Gains
LLONG	GO:0016779	nucleotidyltransferase activity	Gains
LLONG	GO:0008378	galactosyltransferase activity	Gains
LLONG	GO:0046914	transition metal ion binding	Gains
LLONG	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
LLONG	GO:0020037	heme binding	Gains
LLONG	GO:0046872	metal ion binding	Gains
LLONG	GO:0046906	tetrapyrrole binding	Gains
LLONG	GO:0030976	thiamine pyrophosphate binding	Gains
LLONG	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
LLONG	GO:0017048	Rho GTPase binding	Gains
LLONG	GO:0016757	transferase activity, transferring glycosyl groups	Gains
LLONG	GO:0016740	transferase activity	Gains
LLONG	GO:0004672	protein kinase activity	Gains
LLONG	GO:0019899	enzyme binding	Gains
LLONG	GO:0019199	transmembrane receptor protein kinase activity	Gains
LLONG	GO:0004004	ATP-dependent RNA helicase activity	Gains
LLONG	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
LLONG	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
LLONG	GO:0008134	transcription factor binding	Losses
LLONG	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Losses
LLONG	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Losses
LLONG	GO:0070491	repressing transcription factor binding	Losses
LLONG	GO:0015002	heme-copper terminal oxidase activity	Losses
LLONG	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
LLONG	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
LLONG	GO:0004129	cytochrome-c oxidase activity	Losses
LLONG	GO:0009881	photoreceptor activity	Losses
LLONG	GO:0005198	structural molecule activity	Losses
LLONG	GO:0033218	amide binding	Losses
LLONG	GO:0016854	racemase and epimerase activity	Losses
LLONG	GO:0016788	hydrolase activity, acting on ester bonds	Losses
LLONG	GO:0008135	translation factor activity, RNA binding	Losses
LLONG	GO:0042277	peptide binding	Losses
LLONG	GO:0003735	structural constituent of ribosome	Losses
LLONG	GO:0044389	ubiquitin-like protein ligase binding	Losses
LLONG	GO:0017150	tRNA dihydrouridine synthase activity	Losses
LLONG	GO:0015368	calcium:cation antiporter activity	Losses
LLONG	GO:0031625	ubiquitin protein ligase binding	Losses
LLONG	GO:0022821	potassium ion antiporter activity	Losses
LLONG	GO:0005272	sodium channel activity	Losses
LLONG	GO:0022890	inorganic cation transmembrane transporter activity	Losses
LLONG	GO:0042562	hormone binding	Losses
LLONG	GO:0003743	translation initiation factor activity	Losses
LLONG	GO:0004620	phospholipase activity	Losses
LLONG	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Losses
LLONG	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
LLONG	GO:0036442	hydrogen-exporting ATPase activity	Losses
LLONG	GO:0016877	ligase activity, forming carbon-sulfur bonds	Losses
LLONG	GO:0052689	carboxylic ester hydrolase activity	Losses
LLONG	GO:0004597	peptide-aspartate beta-dioxygenase activity	Losses
LLONG	GO:0004503	monophenol monooxygenase activity	Losses
LLONG	GO:0032033	myosin II light chain binding	Losses
LLONG	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
LLONG	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
LLONG	GO:0004033	aldo-keto reductase (NADP) activity	Losses
LLONG	GO:0008445	D-aspartate oxidase activity	Losses
LLONG	GO:0015922	aspartate oxidase activity	Losses
LLONG	GO:0009882	blue light photoreceptor activity	Losses
LLONG	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
LLONG	GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
LLONG	GO:0008273	calcium, potassium:sodium antiporter activity	Losses
LLONG	GO:0004305	ethanolamine kinase activity	Losses
LLONG	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Losses
LLONG	GO:0003884	D-amino-acid oxidase activity	Losses
LLONG	GO:0004103	choline kinase activity	Losses
LLONG	GO:0008545	JUN kinase kinase activity	Losses
LLONG	GO:0050833	pyruvate transmembrane transporter activity	Losses
LLONG	GO:0001221	transcription cofactor binding	Losses
LLONG	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
LLONG	GO:0008641	ubiquitin-like modifier activating enzyme activity	Losses
LLONG	GO:0016298	lipase activity	Losses
LLONG	GO:0016411	acylglycerol O-acyltransferase activity	Losses
LLONG	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Losses
LLONG	GO:0030234	enzyme regulator activity	Losses
LLONG	GO:0008195	phosphatidate phosphatase activity	Losses
LLONG	GO:0004623	phospholipase A2 activity	Losses
LLONG	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
LLONG	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
LLONG	GO:0016854	racemase and epimerase activity	Extinctions
LLONG	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Extinctions
LLONG	GO:0003735	structural constituent of ribosome	Extinctions
LLONG	GO:0008134	transcription factor binding	Extinctions
LLONG	GO:0070491	repressing transcription factor binding	Extinctions
LLONG	GO:0016877	ligase activity, forming carbon-sulfur bonds	Extinctions
LLONG	GO:0017150	tRNA dihydrouridine synthase activity	Extinctions
LLONG	GO:0015368	calcium:cation antiporter activity	Extinctions
LLONG	GO:0022821	potassium ion antiporter activity	Extinctions
LLONG	GO:0015002	heme-copper terminal oxidase activity	Extinctions
LLONG	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
LLONG	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
LLONG	GO:0004129	cytochrome-c oxidase activity	Extinctions
LLONG	GO:0003743	translation initiation factor activity	Extinctions
LLONG	GO:0004623	phospholipase A2 activity	Extinctions
LLONG	GO:0008641	ubiquitin-like modifier activating enzyme activity	Extinctions
LLONG	GO:0008135	translation factor activity, RNA binding	Extinctions
LLONG	GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
LLONG	GO:0008445	D-aspartate oxidase activity	Extinctions
LLONG	GO:0015922	aspartate oxidase activity	Extinctions
LLONG	GO:0008273	calcium, potassium:sodium antiporter activity	Extinctions
LLONG	GO:0004305	ethanolamine kinase activity	Extinctions
LLONG	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Extinctions
LLONG	GO:0003884	D-amino-acid oxidase activity	Extinctions
LLONG	GO:0004103	choline kinase activity	Extinctions
LLONG	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Extinctions
LLONG	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Extinctions
LLONG	GO:0036442	hydrogen-exporting ATPase activity	Extinctions
LLONG	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
TCAST	GO:0005549	odorant binding	Gains
TCAST	GO:0004984	olfactory receptor activity	Gains
TCAST	GO:0099600	transmembrane receptor activity	Gains
TCAST	GO:0004888	transmembrane signaling receptor activity	Gains
TCAST	GO:0038023	signaling receptor activity	Gains
TCAST	GO:0004930	G-protein coupled receptor activity	Gains
TCAST	GO:0004872	receptor activity	Gains
TCAST	GO:0060089	molecular transducer activity	Gains
TCAST	GO:0004871	signal transducer activity	Gains
TCAST	GO:0008527	taste receptor activity	Gains
TCAST	GO:0003964	RNA-directed DNA polymerase activity	Gains
TCAST	GO:0034061	DNA polymerase activity	Gains
TCAST	GO:0140097	catalytic activity, acting on DNA	Gains
TCAST	GO:0022824	transmitter-gated ion channel activity	Gains
TCAST	GO:0022835	transmitter-gated channel activity	Gains
TCAST	GO:0004970	ionotropic glutamate receptor activity	Gains
TCAST	GO:0015276	ligand-gated ion channel activity	Gains
TCAST	GO:0022834	ligand-gated channel activity	Gains
TCAST	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
TCAST	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
TCAST	GO:0005230	extracellular ligand-gated ion channel activity	Gains
TCAST	GO:0008066	glutamate receptor activity	Gains
TCAST	GO:0030594	neurotransmitter receptor activity	Gains
TCAST	GO:0016779	nucleotidyltransferase activity	Gains
TCAST	GO:0022836	gated channel activity	Gains
TCAST	GO:0005216	ion channel activity	Gains
TCAST	GO:0022838	substrate-specific channel activity	Gains
TCAST	GO:0015267	channel activity	Gains
TCAST	GO:0022803	passive transmembrane transporter activity	Gains
TCAST	GO:0004190	aspartic-type endopeptidase activity	Gains
TCAST	GO:0070001	aspartic-type peptidase activity	Gains
TCAST	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
TCAST	GO:0033041	sweet taste receptor activity	Gains
TCAST	GO:0022891	substrate-specific transmembrane transporter activity	Gains
TCAST	GO:0022857	transmembrane transporter activity	Gains
TCAST	GO:0015075	ion transmembrane transporter activity	Gains
TCAST	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
TCAST	GO:0005215	transporter activity	Gains
TCAST	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
TCAST	GO:0070330	aromatase activity	Gains
TCAST	GO:0022892	substrate-specific transporter activity	Gains
TCAST	GO:0004497	monooxygenase activity	Gains
TCAST	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Gains
TCAST	GO:0015141	succinate transmembrane transporter activity	Gains
TCAST	GO:0005550	pheromone binding	Gains
TCAST	GO:0018685	alkane 1-monooxygenase activity	Gains
TCAST	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
TCAST	GO:0005315	inorganic phosphate transmembrane transporter activity	Gains
TCAST	GO:0050591	quinine 3-monooxygenase activity	Gains
TCAST	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
TCAST	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
TCAST	GO:0008233	peptidase activity	Gains
TCAST	GO:0004803	transposase activity	Gains
TCAST	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
TCAST	GO:0004692	cGMP-dependent protein kinase activity	Gains
TCAST	GO:0004629	phospholipase C activity	Gains
TCAST	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
TCAST	GO:0016763	transferase activity, transferring pentosyl groups	Gains
TCAST	GO:0030553	cGMP binding	Gains
TCAST	GO:0008853	exodeoxyribonuclease III activity	Gains
TCAST	GO:0015116	sulfate transmembrane transporter activity	Gains
TCAST	GO:0004555	alpha,alpha-trehalase activity	Gains
TCAST	GO:0016406	carnitine O-acyltransferase activity	Gains
TCAST	GO:0050308	sugar-phosphatase activity	Gains
TCAST	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
TCAST	GO:0047429	nucleoside-triphosphate diphosphatase activity	Gains
TCAST	GO:0015927	trehalase activity	Gains
TCAST	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Gains
TCAST	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
TCAST	GO:0005272	sodium channel activity	Gains
TCAST	GO:0008812	choline dehydrogenase activity	Gains
TCAST	GO:0004175	endopeptidase activity	Gains
TCAST	GO:0008061	chitin binding	Gains
TCAST	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
TCAST	GO:0008408	3'-5' exonuclease activity	Gains
TCAST	GO:0004529	exodeoxyribonuclease activity	Gains
TCAST	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	Gains
TCAST	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
TCAST	GO:0015114	phosphate ion transmembrane transporter activity	Gains
TCAST	GO:1901677	phosphate transmembrane transporter activity	Gains
TCAST	GO:0017080	sodium channel regulator activity	Gains
TCAST	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Gains
TCAST	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Gains
TCAST	GO:0016803	ether hydrolase activity	Gains
TCAST	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
TCAST	GO:0004672	protein kinase activity	Losses
TCAST	GO:0016301	kinase activity	Losses
TCAST	GO:0036002	pre-mRNA binding	Losses
TCAST	GO:0004016	adenylate cyclase activity	Losses
TCAST	GO:0016453	C-acetyltransferase activity	Losses
TCAST	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
TCAST	GO:0097157	pre-mRNA intronic binding	Losses
TCAST	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
TCAST	GO:0019199	transmembrane receptor protein kinase activity	Losses
TCAST	GO:0008236	serine-type peptidase activity	Losses
TCAST	GO:0004871	signal transducer activity	Losses
TCAST	GO:0017171	serine hydrolase activity	Losses
TCAST	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
TCAST	GO:0140096	catalytic activity, acting on a protein	Losses
TCAST	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
TCAST	GO:0004713	protein tyrosine kinase activity	Losses
TCAST	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
TCAST	GO:0042910	xenobiotic transmembrane transporter activity	Losses
TCAST	GO:0031683	G-protein beta/gamma-subunit complex binding	Losses
TCAST	GO:0042043	neurexin family protein binding	Losses
TCAST	GO:0030976	thiamine pyrophosphate binding	Losses
TCAST	GO:0004687	myosin light chain kinase activity	Losses
TCAST	GO:0071949	FAD binding	Losses
TCAST	GO:0008324	cation transmembrane transporter activity	Losses
TCAST	GO:0004674	protein serine/threonine kinase activity	Losses
TCAST	GO:0008061	chitin binding	Losses
TCAST	GO:0015238	drug transmembrane transporter activity	Losses
TCAST	GO:0004983	neuropeptide Y receptor activity	Losses
TCAST	GO:0090484	drug transporter activity	Losses
TCAST	GO:0004252	serine-type endopeptidase activity	Losses
TCAST	GO:0031409	pigment binding	Losses
TCAST	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
TCAST	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
TCAST	GO:0016791	phosphatase activity	Losses
TCAST	GO:0015499	formate transmembrane transporter activity	Losses
TCAST	GO:0008890	glycine C-acetyltransferase activity	Losses
TCAST	GO:0016018	cyclosporin A binding	Losses
TCAST	GO:0008887	glycerate kinase activity	Losses
TCAST	GO:0052856	NADHX epimerase activity	Losses
TCAST	GO:0016933	extracellularly glycine-gated ion channel activity	Losses
TCAST	GO:0008801	beta-phosphoglucomutase activity	Losses
TCAST	GO:0004782	sulfinoalanine decarboxylase activity	Losses
TCAST	GO:0001106	RNA polymerase II transcription corepressor activity	Losses
TCAST	GO:0070735	protein-glycine ligase activity	Losses
TCAST	GO:0070736	protein-glycine ligase activity, initiating	Losses
TCAST	GO:0070737	protein-glycine ligase activity, elongating	Losses
TCAST	GO:0004727	prenylated protein tyrosine phosphatase activity	Losses
TCAST	GO:0060308	GTP cyclohydrolase I regulator activity	Losses
TCAST	GO:0015106	bicarbonate transmembrane transporter activity	Losses
TCAST	GO:0071837	HMG box domain binding	Losses
TCAST	GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Losses
TCAST	GO:0033192	calmodulin-dependent protein phosphatase activity	Losses
TCAST	GO:0000224	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	Losses
TCAST	GO:0010461	light-activated ion channel activity	Losses
TCAST	GO:0004802	transketolase activity	Losses
TCAST	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Losses
TCAST	GO:0019531	oxalate transmembrane transporter activity	Losses
TCAST	GO:0003998	acylphosphatase activity	Losses
TCAST	GO:0003985	acetyl-CoA C-acetyltransferase activity	Losses
TCAST	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
TCAST	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
TCAST	GO:0048531	beta-1,3-galactosyltransferase activity	Losses
TCAST	GO:0008999	ribosomal-protein-alanine N-acetyltransferase activity	Losses
TCAST	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	Losses
TCAST	GO:0033858	N-acetylgalactosamine kinase activity	Losses
TCAST	GO:0035175	histone kinase activity (H3-S10 specific)	Losses
TCAST	GO:0005003	ephrin receptor activity	Losses
TCAST	GO:0004068	aspartate 1-decarboxylase activity	Losses
TCAST	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Losses
TCAST	GO:0004020	adenylylsulfate kinase activity	Losses
TCAST	GO:0071906	CRD domain binding	Losses
TCAST	GO:0043914	NADPH:sulfur oxidoreductase activity	Losses
TCAST	GO:0004946	bombesin receptor activity	Losses
TCAST	GO:0050221	prostaglandin-E2 9-reductase activity	Losses
TCAST	GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Losses
TCAST	GO:0050780	dopamine receptor binding	Losses
TCAST	GO:0004351	glutamate decarboxylase activity	Losses
TCAST	GO:0031752	D5 dopamine receptor binding	Losses
TCAST	GO:0016618	hydroxypyruvate reductase activity	Losses
TCAST	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Losses
TCAST	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
TCAST	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
TCAST	GO:0016408	C-acyltransferase activity	Losses
TCAST	GO:0022890	inorganic cation transmembrane transporter activity	Losses
TCAST	GO:0036002	pre-mRNA binding	Extinctions
TCAST	GO:0097157	pre-mRNA intronic binding	Extinctions
TCAST	GO:0030976	thiamine pyrophosphate binding	Extinctions
TCAST	GO:0052856	NADHX epimerase activity	Extinctions
TCAST	GO:0000224	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	Extinctions
TCAST	GO:0008999	ribosomal-protein-alanine N-acetyltransferase activity	Extinctions
TCAST	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Extinctions
TCAST	GO:0050780	dopamine receptor binding	Extinctions
TCAST	GO:0031752	D5 dopamine receptor binding	Extinctions
TCAST	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
TCAST	GO:0004142	diacylglycerol cholinephosphotransferase activity	Extinctions
TCAST	GO:0008476	protein-tyrosine sulfotransferase activity	Extinctions
TCAST	GO:0004307	ethanolaminephosphotransferase activity	Extinctions
TCAST	GO:0004427	inorganic diphosphatase activity	Extinctions
TCAST	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
LHESP	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
LHESP	GO:0015408	ferric-transporting ATPase activity	Gains
LHESP	GO:0072510	trivalent inorganic cation transmembrane transporter activity	Gains
LHESP	GO:0015091	ferric iron transmembrane transporter activity	Gains
LHESP	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
LHESP	GO:0051020	GTPase binding	Gains
LHESP	GO:0003964	RNA-directed DNA polymerase activity	Gains
LHESP	GO:0030414	peptidase inhibitor activity	Gains
LHESP	GO:0017016	Ras GTPase binding	Gains
LHESP	GO:0004375	glycine dehydrogenase (decarboxylating) activity	Gains
LHESP	GO:0000182	rDNA binding	Gains
LHESP	GO:0005501	retinoid binding	Gains
LHESP	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	Gains
LHESP	GO:0030060	L-malate dehydrogenase activity	Gains
LHESP	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	Gains
LHESP	GO:0019783	ubiquitin-like protein-specific protease activity	Gains
LHESP	GO:0031267	small GTPase binding	Gains
LHESP	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Gains
LHESP	GO:0101005	ubiquitinyl hydrolase activity	Gains
LHESP	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Gains
LHESP	GO:0003713	transcription coactivator activity	Gains
LHESP	GO:0034061	DNA polymerase activity	Gains
LHESP	GO:0005381	iron ion transmembrane transporter activity	Gains
LHESP	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
LHESP	GO:0008233	peptidase activity	Gains
LHESP	GO:0061134	peptidase regulator activity	Gains
LHESP	GO:0004866	endopeptidase inhibitor activity	Gains
LHESP	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
LHESP	GO:0003712	transcription cofactor activity	Gains
LHESP	GO:0050839	cell adhesion molecule binding	Gains
LHESP	GO:0003696	satellite DNA binding	Gains
LHESP	GO:0004819	glutamine-tRNA ligase activity	Gains
LHESP	GO:0030898	actin-dependent ATPase activity	Gains
LHESP	GO:0004617	phosphoglycerate dehydrogenase activity	Gains
LHESP	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Gains
LHESP	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
LHESP	GO:0001104	RNA polymerase II transcription cofactor activity	Gains
LHESP	GO:0008234	cysteine-type peptidase activity	Gains
LHESP	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
LHESP	GO:0016905	myosin heavy chain kinase activity	Gains
LHESP	GO:0000149	SNARE binding	Gains
LHESP	GO:0004806	triglyceride lipase activity	Gains
LHESP	GO:0017137	Rab GTPase binding	Gains
LHESP	GO:0061135	endopeptidase regulator activity	Gains
LHESP	GO:0004872	receptor activity	Losses
LHESP	GO:0004930	G-protein coupled receptor activity	Losses
LHESP	GO:0005102	receptor binding	Losses
LHESP	GO:0004888	transmembrane signaling receptor activity	Losses
LHESP	GO:0099600	transmembrane receptor activity	Losses
LHESP	GO:0060089	molecular transducer activity	Losses
LHESP	GO:0038023	signaling receptor activity	Losses
LHESP	GO:0001653	peptide receptor activity	Losses
LHESP	GO:0015081	sodium ion transmembrane transporter activity	Losses
LHESP	GO:0008528	G-protein coupled peptide receptor activity	Losses
LHESP	GO:0016859	cis-trans isomerase activity	Losses
LHESP	GO:0008188	neuropeptide receptor activity	Losses
LHESP	GO:0004364	glutathione transferase activity	Losses
LHESP	GO:0019206	nucleoside kinase activity	Losses
LHESP	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
LHESP	GO:0004849	uridine kinase activity	Losses
LHESP	GO:0042834	peptidoglycan binding	Losses
LHESP	GO:0008083	growth factor activity	Losses
LHESP	GO:0016247	channel regulator activity	Losses
LHESP	GO:0004871	signal transducer activity	Losses
LHESP	GO:0005272	sodium channel activity	Losses
LHESP	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Losses
LHESP	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Losses
LHESP	GO:0004175	endopeptidase activity	Losses
LHESP	GO:0004190	aspartic-type endopeptidase activity	Losses
LHESP	GO:0050254	rhodopsin kinase activity	Losses
LHESP	GO:0070001	aspartic-type peptidase activity	Losses
LHESP	GO:0005044	scavenger receptor activity	Losses
LHESP	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
LHESP	GO:0015293	symporter activity	Losses
LHESP	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Losses
LHESP	GO:0004983	neuropeptide Y receptor activity	Losses
LHESP	GO:0003684	damaged DNA binding	Losses
LHESP	GO:0008812	choline dehydrogenase activity	Losses
LHESP	GO:0016303	1-phosphatidylinositol-3-kinase activity	Losses
LHESP	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
LHESP	GO:0009922	fatty acid elongase activity	Losses
LHESP	GO:0099106	ion channel regulator activity	Losses
LHESP	GO:0045289	luciferin monooxygenase activity	Losses
LHESP	GO:0003735	structural constituent of ribosome	Losses
LHESP	GO:1901505	carbohydrate derivative transmembrane transporter activity	Losses
LHESP	GO:0015144	carbohydrate transmembrane transporter activity	Losses
LHESP	GO:0051119	sugar transmembrane transporter activity	Losses
LHESP	GO:0005343	organic acid:sodium symporter activity	Losses
LHESP	GO:0005402	cation:sugar symporter activity	Losses
LHESP	GO:0005154	epidermal growth factor receptor binding	Losses
LHESP	GO:0015295	solute:proton symporter activity	Losses
LHESP	GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
LHESP	GO:0001102	RNA polymerase II activating transcription factor binding	Losses
LHESP	GO:0070851	growth factor receptor binding	Losses
LHESP	GO:0019955	cytokine binding	Losses
LHESP	GO:0005351	sugar:proton symporter activity	Losses
LHESP	GO:0005338	nucleotide-sugar transmembrane transporter activity	Losses
LHESP	GO:0035251	UDP-glucosyltransferase activity	Losses
LHESP	GO:0003735	structural constituent of ribosome	Extinctions
LHESP	GO:0016859	cis-trans isomerase activity	Extinctions
LHESP	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
LHESP	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Extinctions
LHESP	GO:0004364	glutathione transferase activity	Extinctions
LHESP	GO:0004659	prenyltransferase activity	Extinctions
LHESP	GO:0001102	RNA polymerase II activating transcription factor binding	Extinctions
LHESP	GO:0005338	nucleotide-sugar transmembrane transporter activity	Extinctions
LHESP	GO:0008187	poly-pyrimidine tract binding	Extinctions
LHESP	GO:0004930	G-protein coupled receptor activity	Extinctions
LHESP	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Extinctions
LHESP	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	Extinctions
LHESP	GO:0019212	phosphatase inhibitor activity	Extinctions
LHESP	GO:0004849	uridine kinase activity	Extinctions
LHESP	GO:0008195	phosphatidate phosphatase activity	Extinctions
48	GO:0005549	odorant binding	Gains
48	GO:0004984	olfactory receptor activity	Gains
48	GO:0008061	chitin binding	Gains
48	GO:0004364	glutathione transferase activity	Gains
48	GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
48	GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
48	GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
48	GO:0052834	inositol monophosphate phosphatase activity	Gains
48	GO:0016848	carbon-halide lyase activity	Gains
48	GO:0005179	hormone activity	Gains
48	GO:0008527	taste receptor activity	Gains
48	GO:0048018	receptor ligand activity	Gains
48	GO:0005184	neuropeptide hormone activity	Gains
48	GO:0008237	metallopeptidase activity	Gains
48	GO:0004930	G-protein coupled receptor activity	Gains
48	GO:0030545	receptor regulator activity	Gains
48	GO:0004252	serine-type endopeptidase activity	Gains
48	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
48	GO:0099600	transmembrane receptor activity	Gains
48	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
48	GO:0004888	transmembrane signaling receptor activity	Gains
48	GO:0008238	exopeptidase activity	Gains
48	GO:0005550	pheromone binding	Gains
48	GO:0005501	retinoid binding	Gains
48	GO:0031624	ubiquitin conjugating enzyme binding	Gains
48	GO:0044390	ubiquitin-like protein conjugating enzyme binding	Gains
48	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
48	GO:0005102	receptor binding	Gains
48	GO:0008233	peptidase activity	Gains
48	GO:0004175	endopeptidase activity	Gains
48	GO:0008430	selenium binding	Gains
48	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Gains
48	GO:0004784	superoxide dismutase activity	Gains
48	GO:0030246	carbohydrate binding	Gains
48	GO:0099094	ligand-gated cation channel activity	Gains
48	GO:0008236	serine-type peptidase activity	Gains
48	GO:0017171	serine hydrolase activity	Gains
48	GO:0004568	chitinase activity	Gains
48	GO:0003964	RNA-directed DNA polymerase activity	Losses
48	GO:0034061	DNA polymerase activity	Losses
48	GO:0140097	catalytic activity, acting on DNA	Losses
48	GO:0016779	nucleotidyltransferase activity	Losses
48	GO:0008270	zinc ion binding	Losses
48	GO:0046914	transition metal ion binding	Losses
48	GO:0004519	endonuclease activity	Losses
48	GO:0004518	nuclease activity	Losses
48	GO:0070001	aspartic-type peptidase activity	Losses
48	GO:0004190	aspartic-type endopeptidase activity	Losses
48	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
48	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
48	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
48	GO:0046872	metal ion binding	Losses
48	GO:0043169	cation binding	Losses
48	GO:0016740	transferase activity	Losses
48	GO:0003677	DNA binding	Losses
48	GO:1901363	heterocyclic compound binding	Losses
48	GO:0097159	organic cyclic compound binding	Losses
48	GO:0003676	nucleic acid binding	Losses
48	GO:0015928	fucosidase activity	Losses
48	GO:0004560	alpha-L-fucosidase activity	Losses
48	GO:0048019	receptor antagonist activity	Losses
48	GO:0030547	receptor inhibitor activity	Losses
48	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
48	GO:0003824	catalytic activity	Losses
48	GO:0016788	hydrolase activity, acting on ester bonds	Losses
48	GO:0008417	fucosyltransferase activity	Losses
48	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
48	GO:0016787	hydrolase activity	Losses
48	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
48	GO:0097747	RNA polymerase activity	Losses
48	GO:0034062	5'-3' RNA polymerase activity	Losses
48	GO:0004736	pyruvate carboxylase activity	Losses
48	GO:0005158	insulin receptor binding	Losses
48	GO:0043167	ion binding	Losses
48	GO:0016209	antioxidant activity	Losses
48	GO:0009008	DNA-methyltransferase activity	Losses
48	GO:0005154	epidermal growth factor receptor binding	Losses
48	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Losses
48	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
48	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Losses
48	GO:0004075	biotin carboxylase activity	Losses
48	GO:0004175	endopeptidase activity	Losses
48	GO:0004521	endoribonuclease activity	Losses
48	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
48	GO:0004803	transposase activity	Losses
48	GO:0070851	growth factor receptor binding	Losses
48	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
48	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Losses
48	GO:0004725	protein tyrosine phosphatase activity	Losses
48	GO:0008568	microtubule-severing ATPase activity	Losses
48	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
48	GO:0047325	inositol tetrakisphosphate 1-kinase activity	Losses
48	GO:0004557	alpha-galactosidase activity	Losses
48	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Losses
48	GO:0004531	deoxyribonuclease II activity	Losses
48	GO:0004507	steroid 11-beta-monooxygenase activity	Losses
48	GO:0000700	mismatch base pair DNA N-glycosylase activity	Losses
48	GO:0004667	prostaglandin-D synthase activity	Losses
48	GO:0004651	polynucleotide 5'-phosphatase activity	Losses
48	GO:0008086	light-activated voltage-gated calcium channel activity	Losses
48	GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	Losses
48	GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	Losses
48	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	Losses
48	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
48	GO:0004068	aspartate 1-decarboxylase activity	Losses
48	GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Losses
48	GO:0052692	raffinose alpha-galactosidase activity	Losses
48	GO:0004034	aldose 1-epimerase activity	Losses
48	GO:0042806	fucose binding	Losses
48	GO:0047749	cholestanetriol 26-monooxygenase activity	Losses
48	GO:0030586	[methionine synthase] reductase activity	Losses
48	GO:0047880	erythrulose reductase activity	Losses
48	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
48	GO:0070735	protein-glycine ligase activity	Losses
48	GO:0070736	protein-glycine ligase activity, initiating	Losses
48	GO:0070737	protein-glycine ligase activity, elongating	Losses
48	GO:0010461	light-activated ion channel activity	Losses
48	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
48	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	Losses
48	GO:0047536	2-aminoadipate transaminase activity	Losses
48	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
48	GO:0004351	glutamate decarboxylase activity	Losses
48	GO:0005436	sodium:phosphate symporter activity	Losses
48	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Losses
48	GO:0004339	glucan 1,4-alpha-glucosidase activity	Losses
48	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Losses
48	GO:0047635	alanine-oxo-acid transaminase activity	Losses
48	GO:0032576	O-linoleoyltransferase activity	Losses
48	GO:0032577	phosphatidylcholine:cardiolipin O-linoleoyltransferase activity	Losses
48	GO:0005159	insulin-like growth factor receptor binding	Losses
48	GO:0032542	sulfiredoxin activity	Losses
48	GO:0003873	6-phosphofructo-2-kinase activity	Losses
48	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
48	GO:0019992	diacylglycerol binding	Losses
48	GO:0008743	L-threonine 3-dehydrogenase activity	Losses
48	GO:0042925	benzoate transmembrane transporter activity	Losses
48	GO:0051765	inositol tetrakisphosphate kinase activity	Losses
48	GO:0008801	beta-phosphoglucomutase activity	Losses
48	GO:0050277	sedoheptulokinase activity	Losses
48	GO:0050221	prostaglandin-E2 9-reductase activity	Losses
48	GO:0004782	sulfinoalanine decarboxylase activity	Losses
48	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Losses
48	GO:0097493	structural molecule activity conferring elasticity	Losses
48	GO:0008061	chitin binding	Novel expansions
48	GO:0008270	zinc ion binding	Novel expansions
48	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Novel expansions
48	GO:0030331	estrogen receptor binding	Novel expansions
48	GO:0004096	catalase activity	Novel expansions
48	GO:0004817	cysteine-tRNA ligase activity	Novel expansions
48	GO:0035258	steroid hormone receptor binding	Novel expansions
48	GO:0046914	transition metal ion binding	Novel expansions
48	GO:0035326	enhancer binding	Novel expansions
48	GO:0001158	enhancer sequence-specific DNA binding	Novel expansions
48	GO:0008613	diuretic hormone activity	Novel expansions
48	GO:0031624	ubiquitin conjugating enzyme binding	Novel expansions
48	GO:0044390	ubiquitin-like protein conjugating enzyme binding	Novel expansions
48	GO:0051427	hormone receptor binding	Novel expansions
48	GO:0005158	insulin receptor binding	Novel expansions
48	GO:0035257	nuclear hormone receptor binding	Novel expansions
48	GO:0016209	antioxidant activity	Novel expansions
48	GO:0005085	guanyl-nucleotide exchange factor activity	Novel expansions
48	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
48	GO:0034061	DNA polymerase activity	Extinctions
48	GO:0140097	catalytic activity, acting on DNA	Extinctions
48	GO:0016779	nucleotidyltransferase activity	Extinctions
48	GO:0008270	zinc ion binding	Extinctions
48	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Extinctions
48	GO:0046914	transition metal ion binding	Extinctions
48	GO:1901363	heterocyclic compound binding	Extinctions
48	GO:0097159	organic cyclic compound binding	Extinctions
48	GO:0009008	DNA-methyltransferase activity	Extinctions
48	GO:0003676	nucleic acid binding	Extinctions
48	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Extinctions
48	GO:0008168	methyltransferase activity	Extinctions
48	GO:0008568	microtubule-severing ATPase activity	Extinctions
48	GO:0003677	DNA binding	Extinctions
48	GO:0016741	transferase activity, transferring one-carbon groups	Extinctions
48	GO:0008417	fucosyltransferase activity	Extinctions
48	GO:0047325	inositol tetrakisphosphate 1-kinase activity	Extinctions
48	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Extinctions
48	GO:0004531	deoxyribonuclease II activity	Extinctions
48	GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
48	GO:0000700	mismatch base pair DNA N-glycosylase activity	Extinctions
48	GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	Extinctions
48	GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	Extinctions
48	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	Extinctions
48	GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
48	GO:0030586	[methionine synthase] reductase activity	Extinctions
48	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
48	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	Extinctions
48	GO:0047536	2-aminoadipate transaminase activity	Extinctions
48	GO:0004339	glucan 1,4-alpha-glucosidase activity	Extinctions
48	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Extinctions
48	GO:0032576	O-linoleoyltransferase activity	Extinctions
48	GO:0032577	phosphatidylcholine:cardiolipin O-linoleoyltransferase activity	Extinctions
48	GO:0005159	insulin-like growth factor receptor binding	Extinctions
48	GO:0032542	sulfiredoxin activity	Extinctions
48	GO:0008743	L-threonine 3-dehydrogenase activity	Extinctions
48	GO:0042925	benzoate transmembrane transporter activity	Extinctions
48	GO:0051765	inositol tetrakisphosphate kinase activity	Extinctions
48	GO:0050277	sedoheptulokinase activity	Extinctions
48	GO:0050221	prostaglandin-E2 9-reductase activity	Extinctions
48	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Extinctions
48	GO:0004622	lysophospholipase activity	Extinctions
48	GO:0070403	NAD+ binding	Extinctions
48	GO:0004767	sphingomyelin phosphodiesterase activity	Extinctions
48	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Extinctions
49	GO:0022834	ligand-gated channel activity	Gains
49	GO:0015276	ligand-gated ion channel activity	Gains
49	GO:0042834	peptidoglycan binding	Gains
49	GO:0042302	structural constituent of cuticle	Gains
49	GO:0060089	molecular transducer activity	Gains
49	GO:0004872	receptor activity	Gains
49	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
49	GO:0099600	transmembrane receptor activity	Gains
49	GO:0099094	ligand-gated cation channel activity	Gains
49	GO:0005550	pheromone binding	Gains
49	GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
49	GO:0038023	signaling receptor activity	Gains
49	GO:0005230	extracellular ligand-gated ion channel activity	Gains
49	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
49	GO:0005549	odorant binding	Gains
49	GO:0022836	gated channel activity	Gains
49	GO:0022857	transmembrane transporter activity	Gains
49	GO:0016803	ether hydrolase activity	Gains
49	GO:0022891	substrate-specific transmembrane transporter activity	Gains
49	GO:0005214	structural constituent of chitin-based cuticle	Gains
49	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
49	GO:0022892	substrate-specific transporter activity	Gains
49	GO:0004871	signal transducer activity	Gains
49	GO:0005539	glycosaminoglycan binding	Gains
49	GO:0071855	neuropeptide receptor binding	Gains
49	GO:0046914	transition metal ion binding	Gains
49	GO:0003707	steroid hormone receptor activity	Gains
49	GO:0016801	hydrolase activity, acting on ether bonds	Gains
49	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
49	GO:0005216	ion channel activity	Gains
49	GO:0022838	substrate-specific channel activity	Gains
49	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Gains
49	GO:0016211	ammonia ligase activity	Gains
49	GO:0045735	nutrient reservoir activity	Gains
49	GO:0008515	sucrose transmembrane transporter activity	Gains
49	GO:0050897	cobalt ion binding	Gains
49	GO:0044736	acid-sensing ion channel activity	Gains
49	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Gains
49	GO:0035274	diphenyl phthalate binding	Gains
49	GO:0035275	dibutyl phthalate binding	Gains
49	GO:0000257	nitrilase activity	Gains
49	GO:0035237	corazonin receptor activity	Gains
49	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Gains
49	GO:0004556	alpha-amylase activity	Gains
49	GO:0001875	lipopolysaccharide receptor activity	Gains
49	GO:0042165	neurotransmitter binding	Gains
49	GO:0042166	acetylcholine binding	Gains
49	GO:0036132	13-prostaglandin reductase activity	Gains
49	GO:0015322	secondary active oligopeptide transmembrane transporter activity	Gains
49	GO:0032454	histone demethylase activity (H3-K9 specific)	Gains
49	GO:0016019	peptidoglycan receptor activity	Gains
49	GO:0004060	arylamine N-acetyltransferase activity	Gains
49	GO:0004059	aralkylamine N-acetyltransferase activity	Gains
49	GO:0071859	neuropeptide F receptor binding	Gains
49	GO:0004037	allantoicase activity	Gains
49	GO:0004038	allantoinase activity	Gains
49	GO:0004971	AMPA glutamate receptor activity	Gains
49	GO:0008459	chondroitin 6-sulfotransferase activity	Gains
49	GO:0015280	ligand-gated sodium channel activity	Gains
49	GO:0070576	vitamin D 24-hydroxylase activity	Gains
49	GO:0050309	sugar-terminal-phosphatase activity	Gains
49	GO:0004356	glutamate-ammonia ligase activity	Gains
49	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
49	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity	Gains
49	GO:0004346	glucose-6-phosphatase activity	Gains
49	GO:0004301	epoxide hydrolase activity	Gains
49	GO:0016160	amylase activity	Gains
49	GO:0050112	inositol 2-dehydrogenase activity	Gains
49	GO:0032500	muramyl dipeptide binding	Gains
49	GO:0061783	peptidoglycan muralytic activity	Gains
49	GO:0005215	transporter activity	Gains
49	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
49	GO:0004888	transmembrane signaling receptor activity	Gains
49	GO:0022803	passive transmembrane transporter activity	Gains
49	GO:0015267	channel activity	Gains
49	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Gains
49	GO:0022890	inorganic cation transmembrane transporter activity	Gains
49	GO:0015075	ion transmembrane transporter activity	Gains
49	GO:0004180	carboxypeptidase activity	Gains
49	GO:0008270	zinc ion binding	Gains
49	GO:0008146	sulfotransferase activity	Gains
49	GO:0004930	G-protein coupled receptor activity	Gains
49	GO:0004497	monooxygenase activity	Gains
49	GO:0003964	RNA-directed DNA polymerase activity	Losses
49	GO:0034061	DNA polymerase activity	Losses
49	GO:0046872	metal ion binding	Losses
49	GO:0043169	cation binding	Losses
49	GO:0003676	nucleic acid binding	Losses
49	GO:0016779	nucleotidyltransferase activity	Losses
49	GO:0140097	catalytic activity, acting on DNA	Losses
49	GO:0004930	G-protein coupled receptor activity	Losses
49	GO:0004888	transmembrane signaling receptor activity	Losses
49	GO:0046914	transition metal ion binding	Losses
49	GO:0003677	DNA binding	Losses
49	GO:0008270	zinc ion binding	Losses
49	GO:0099600	transmembrane receptor activity	Losses
49	GO:0070001	aspartic-type peptidase activity	Losses
49	GO:0004190	aspartic-type endopeptidase activity	Losses
49	GO:0098988	G-protein coupled glutamate receptor activity	Losses
49	GO:0015927	trehalase activity	Losses
49	GO:0004555	alpha,alpha-trehalase activity	Losses
49	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Losses
49	GO:0001641	group II metabotropic glutamate receptor activity	Losses
49	GO:0038023	signaling receptor activity	Losses
49	GO:0097159	organic cyclic compound binding	Losses
49	GO:1901363	heterocyclic compound binding	Losses
49	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
49	GO:0004803	transposase activity	Losses
49	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
49	GO:0043167	ion binding	Losses
49	GO:0004175	endopeptidase activity	Losses
49	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
49	GO:0004322	ferroxidase activity	Losses
49	GO:0004518	nuclease activity	Losses
49	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
49	GO:0008066	glutamate receptor activity	Losses
49	GO:0004872	receptor activity	Losses
49	GO:0140104	molecular carrier activity	Losses
49	GO:0003990	acetylcholinesterase activity	Losses
49	GO:0032934	sterol binding	Novel expansions
49	GO:0005496	steroid binding	Novel expansions
49	GO:0097159	organic cyclic compound binding	Novel expansions
49	GO:0004930	G-protein coupled receptor activity	Extinctions
49	GO:0046872	metal ion binding	Extinctions
49	GO:0003676	nucleic acid binding	Extinctions
49	GO:0043169	cation binding	Extinctions
49	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
49	GO:0034061	DNA polymerase activity	Extinctions
49	GO:0016779	nucleotidyltransferase activity	Extinctions
49	GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
49	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
49	GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
49	GO:0140097	catalytic activity, acting on DNA	Extinctions
49	GO:0004888	transmembrane signaling receptor activity	Extinctions
49	GO:0004803	transposase activity	Extinctions
49	GO:0099600	transmembrane receptor activity	Extinctions
49	GO:0008270	zinc ion binding	Extinctions
49	GO:0070001	aspartic-type peptidase activity	Extinctions
49	GO:0004190	aspartic-type endopeptidase activity	Extinctions
49	GO:0046914	transition metal ion binding	Extinctions
49	GO:0038023	signaling receptor activity	Extinctions
49	GO:0140104	molecular carrier activity	Extinctions
49	GO:0003677	DNA binding	Extinctions
49	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
49	GO:0008816	citryl-CoA lyase activity	Extinctions
49	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
49	GO:0008531	riboflavin kinase activity	Extinctions
49	GO:0016595	glutamate binding	Extinctions
49	GO:0031177	phosphopantetheine binding	Extinctions
49	GO:0003920	GMP reductase activity	Extinctions
49	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
49	GO:0051032	nucleic acid transmembrane transporter activity	Extinctions
49	GO:0051033	RNA transmembrane transporter activity	Extinctions
49	GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
49	GO:0035650	AP-1 adaptor complex binding	Extinctions
49	GO:0000036	acyl carrier activity	Extinctions
49	GO:0051192	prosthetic group binding	Extinctions
49	GO:0003720	telomerase activity	Extinctions
49	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
49	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
1	GO:0003964	RNA-directed DNA polymerase activity	Gains
1	GO:0034061	DNA polymerase activity	Gains
1	GO:0140097	catalytic activity, acting on DNA	Gains
1	GO:0016779	nucleotidyltransferase activity	Gains
1	GO:0004175	endopeptidase activity	Gains
1	GO:0070001	aspartic-type peptidase activity	Gains
1	GO:0004190	aspartic-type endopeptidase activity	Gains
1	GO:0004872	receptor activity	Gains
1	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
1	GO:0038023	signaling receptor activity	Gains
1	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
1	GO:0015085	calcium ion transmembrane transporter activity	Gains
1	GO:0060089	molecular transducer activity	Gains
1	GO:0099600	transmembrane receptor activity	Gains
1	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
1	GO:0004888	transmembrane signaling receptor activity	Gains
1	GO:0022836	gated channel activity	Gains
1	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
1	GO:0004871	signal transducer activity	Gains
1	GO:0005216	ion channel activity	Gains
1	GO:0015293	symporter activity	Gains
1	GO:0022838	substrate-specific channel activity	Gains
1	GO:0008233	peptidase activity	Gains
1	GO:0008332	low voltage-gated calcium channel activity	Gains
1	GO:0004415	hyalurononglucosaminidase activity	Gains
1	GO:0046873	metal ion transmembrane transporter activity	Gains
1	GO:0015267	channel activity	Gains
1	GO:0022803	passive transmembrane transporter activity	Gains
1	GO:0005262	calcium channel activity	Gains
1	GO:0005261	cation channel activity	Gains
1	GO:0016740	transferase activity	Gains
1	GO:0004519	endonuclease activity	Gains
1	GO:0003676	nucleic acid binding	Gains
1	GO:0052689	carboxylic ester hydrolase activity	Gains
1	GO:0050660	flavin adenine dinucleotide binding	Gains
1	GO:0004252	serine-type endopeptidase activity	Gains
1	GO:0004686	elongation factor-2 kinase activity	Gains
1	GO:0004040	amidase activity	Gains
1	GO:0004035	alkaline phosphatase activity	Gains
1	GO:0016453	C-acetyltransferase activity	Gains
1	GO:0004518	nuclease activity	Gains
1	GO:0005245	voltage-gated calcium channel activity	Gains
1	GO:0043169	cation binding	Gains
1	GO:0022843	voltage-gated cation channel activity	Gains
1	GO:0004364	glutathione transferase activity	Gains
1	GO:0015291	secondary active transmembrane transporter activity	Gains
1	GO:0008236	serine-type peptidase activity	Gains
1	GO:0046872	metal ion binding	Gains
1	GO:0004930	G-protein coupled receptor activity	Gains
1	GO:0017171	serine hydrolase activity	Gains
1	GO:0008270	zinc ion binding	Gains
1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Gains
1	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
1	GO:0004713	protein tyrosine kinase activity	Gains
1	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
1	GO:0005388	calcium-transporting ATPase activity	Gains
1	GO:0071949	FAD binding	Gains
1	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
1	GO:0008519	ammonium transmembrane transporter activity	Gains
1	GO:0046914	transition metal ion binding	Gains
1	GO:0016788	hydrolase activity, acting on ester bonds	Gains
1	GO:0016298	lipase activity	Gains
1	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
1	GO:0038023	signaling receptor activity	Losses
1	GO:0008417	fucosyltransferase activity	Losses
1	GO:0016805	dipeptidase activity	Losses
1	GO:0004888	transmembrane signaling receptor activity	Losses
1	GO:0004872	receptor activity	Losses
1	GO:0099600	transmembrane receptor activity	Losses
1	GO:0060089	molecular transducer activity	Losses
1	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
1	GO:0005537	mannose binding	Losses
1	GO:0046790	virion binding	Losses
1	GO:0002151	G-quadruplex RNA binding	Losses
1	GO:0015145	monosaccharide transmembrane transporter activity	Losses
1	GO:0015149	hexose transmembrane transporter activity	Losses
1	GO:0036401	pyrokinin receptor activity	Losses
1	GO:0050232	putrescine oxidase activity	Losses
1	GO:0015578	mannose transmembrane transporter activity	Losses
1	GO:0004131	cytosine deaminase activity	Losses
1	GO:0045735	nutrient reservoir activity	Losses
1	GO:0001222	transcription corepressor binding	Losses
1	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
1	GO:0008301	DNA binding, bending	Losses
1	GO:0004970	ionotropic glutamate receptor activity	Losses
1	GO:0022824	transmitter-gated ion channel activity	Losses
1	GO:0022835	transmitter-gated channel activity	Losses
1	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
1	GO:0003777	microtubule motor activity	Losses
1	GO:0004871	signal transducer activity	Losses
1	GO:0008066	glutamate receptor activity	Losses
1	GO:0004004	ATP-dependent RNA helicase activity	Losses
1	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
1	GO:0004503	monophenol monooxygenase activity	Losses
1	GO:0001607	neuromedin U receptor activity	Losses
1	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Losses
1	GO:0004370	glycerol kinase activity	Losses
1	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
1	GO:0004792	thiosulfate sulfurtransferase activity	Losses
1	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Losses
1	GO:0001221	transcription cofactor binding	Losses
1	GO:0001224	RNA polymerase II transcription cofactor binding	Losses
1	GO:0008186	RNA-dependent ATPase activity	Losses
1	GO:0003724	RNA helicase activity	Losses
1	GO:0004654	polyribonucleotide nucleotidyltransferase activity	Losses
1	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Losses
1	GO:0046592	polyamine oxidase activity	Losses
1	GO:0005344	oxygen carrier activity	Losses
1	GO:0004161	dimethylallyltranstransferase activity	Losses
1	GO:0016882	cyclo-ligase activity	Losses
1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
1	GO:0030594	neurotransmitter receptor activity	Losses
1	GO:0017111	nucleoside-triphosphatase activity	Losses
1	GO:0038187	pattern recognition receptor activity	Losses
1	GO:0008329	signaling pattern recognition receptor activity	Losses
1	GO:0046974	histone methyltransferase activity (H3-K9 specific)	Losses
1	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	Losses
1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
1	GO:0016462	pyrophosphatase activity	Losses
1	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Losses
1	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Extinctions
1	GO:0008417	fucosyltransferase activity	Extinctions
1	GO:0016805	dipeptidase activity	Extinctions
1	GO:0005537	mannose binding	Extinctions
1	GO:0015145	monosaccharide transmembrane transporter activity	Extinctions
1	GO:0015149	hexose transmembrane transporter activity	Extinctions
1	GO:0015578	mannose transmembrane transporter activity	Extinctions
1	GO:0045735	nutrient reservoir activity	Extinctions
1	GO:0004970	ionotropic glutamate receptor activity	Extinctions
1	GO:0022824	transmitter-gated ion channel activity	Extinctions
1	GO:0022835	transmitter-gated channel activity	Extinctions
1	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
1	GO:0008066	glutamate receptor activity	Extinctions
1	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
1	GO:0004503	monophenol monooxygenase activity	Extinctions
1	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Extinctions
1	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Extinctions
1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Extinctions
1	GO:0004792	thiosulfate sulfurtransferase activity	Extinctions
1	GO:0030594	neurotransmitter receptor activity	Extinctions
1	GO:0038023	signaling receptor activity	Extinctions
1	GO:0004872	receptor activity	Extinctions
1	GO:0005344	oxygen carrier activity	Extinctions
1	GO:0004161	dimethylallyltranstransferase activity	Extinctions
1	GO:0016882	cyclo-ligase activity	Extinctions
1	GO:0060089	molecular transducer activity	Extinctions
1	GO:0004888	transmembrane signaling receptor activity	Extinctions
1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Extinctions
1	GO:0016500	protein-hormone receptor activity	Extinctions
1	GO:0004767	sphingomyelin phosphodiesterase activity	Extinctions
1	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
1	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Extinctions
1	GO:0004344	glucose dehydrogenase activity	Extinctions
1	GO:0071855	neuropeptide receptor binding	Extinctions
1	GO:0008239	dipeptidyl-peptidase activity	Extinctions
1	GO:0008812	choline dehydrogenase activity	Extinctions
HAZTE	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HAZTE	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HAZTE	GO:0016491	oxidoreductase activity	Gains
HAZTE	GO:0048037	cofactor binding	Gains
HAZTE	GO:0003824	catalytic activity	Gains
HAZTE	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
HAZTE	GO:0036094	small molecule binding	Gains
HAZTE	GO:0016829	lyase activity	Gains
HAZTE	GO:0043168	anion binding	Gains
HAZTE	GO:0050662	coenzyme binding	Gains
HAZTE	GO:0000156	phosphorelay response regulator activity	Gains
HAZTE	GO:0017111	nucleoside-triphosphatase activity	Gains
HAZTE	GO:0017076	purine nucleotide binding	Gains
HAZTE	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
HAZTE	GO:0019842	vitamin binding	Gains
HAZTE	GO:0032553	ribonucleotide binding	Gains
HAZTE	GO:0000166	nucleotide binding	Gains
HAZTE	GO:1901265	nucleoside phosphate binding	Gains
HAZTE	GO:0016462	pyrophosphatase activity	Gains
HAZTE	GO:0050660	flavin adenine dinucleotide binding	Gains
HAZTE	GO:0030554	adenyl nucleotide binding	Gains
HAZTE	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
HAZTE	GO:0032555	purine ribonucleotide binding	Gains
HAZTE	GO:0005215	transporter activity	Gains
HAZTE	GO:0035639	purine ribonucleoside triphosphate binding	Gains
HAZTE	GO:0005524	ATP binding	Gains
HAZTE	GO:0032559	adenyl ribonucleotide binding	Gains
HAZTE	GO:0097367	carbohydrate derivative binding	Gains
HAZTE	GO:0016887	ATPase activity	Gains
HAZTE	GO:0016849	phosphorus-oxygen lyase activity	Gains
HAZTE	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
HAZTE	GO:0003883	CTP synthase activity	Gains
HAZTE	GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
HAZTE	GO:0016151	nickel cation binding	Gains
HAZTE	GO:0004896	cytokine receptor activity	Gains
HAZTE	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
HAZTE	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
HAZTE	GO:0004617	phosphoglycerate dehydrogenase activity	Gains
HAZTE	GO:0004070	aspartate carbamoyltransferase activity	Gains
HAZTE	GO:0030170	pyridoxal phosphate binding	Gains
HAZTE	GO:0070279	vitamin B6 binding	Gains
HAZTE	GO:0042910	xenobiotic transmembrane transporter activity	Gains
HAZTE	GO:0003993	acid phosphatase activity	Gains
HAZTE	GO:0060089	molecular transducer activity	Gains
HAZTE	GO:0004872	receptor activity	Gains
HAZTE	GO:0016836	hydro-lyase activity	Gains
HAZTE	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
HAZTE	GO:0030414	peptidase inhibitor activity	Gains
HAZTE	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
HAZTE	GO:0005452	inorganic anion exchanger activity	Gains
HAZTE	GO:0003964	RNA-directed DNA polymerase activity	Gains
HAZTE	GO:0008483	transaminase activity	Gains
HAZTE	GO:0004866	endopeptidase inhibitor activity	Gains
HAZTE	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
HAZTE	GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
HAZTE	GO:0004871	signal transducer activity	Gains
HAZTE	GO:0022804	active transmembrane transporter activity	Gains
HAZTE	GO:0099600	transmembrane receptor activity	Gains
HAZTE	GO:0016835	carbon-oxygen lyase activity	Gains
HAZTE	GO:0038023	signaling receptor activity	Gains
HAZTE	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
HAZTE	GO:0004658	propionyl-CoA carboxylase activity	Gains
HAZTE	GO:0016841	ammonia-lyase activity	Gains
HAZTE	GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
HAZTE	GO:0003995	acyl-CoA dehydrogenase activity	Gains
HAZTE	GO:0043492	ATPase activity, coupled to movement of substances	Gains
HAZTE	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HAZTE	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
HAZTE	GO:0016840	carbon-nitrogen lyase activity	Gains
HAZTE	GO:0015929	hexosaminidase activity	Gains
HAZTE	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HAZTE	GO:0061135	endopeptidase regulator activity	Gains
HAZTE	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
HAZTE	GO:0004089	carbonate dehydratase activity	Gains
HAZTE	GO:0015103	inorganic anion transmembrane transporter activity	Gains
HAZTE	GO:0033218	amide binding	Gains
HAZTE	GO:0022857	transmembrane transporter activity	Gains
HAZTE	GO:0031406	carboxylic acid binding	Gains
HAZTE	GO:0043177	organic acid binding	Gains
HAZTE	GO:0000155	phosphorelay sensor kinase activity	Gains
HAZTE	GO:0004673	protein histidine kinase activity	Gains
HAZTE	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Gains
HAZTE	GO:0008475	procollagen-lysine 5-dioxygenase activity	Gains
HAZTE	GO:0004372	glycine hydroxymethyltransferase activity	Gains
HAZTE	GO:0016416	O-palmitoyltransferase activity	Gains
HAZTE	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Gains
HAZTE	GO:0016406	carnitine O-acyltransferase activity	Gains
HAZTE	GO:0008658	penicillin binding	Gains
HAZTE	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Gains
HAZTE	GO:0004637	phosphoribosylamine-glycine ligase activity	Gains
HAZTE	GO:0009039	urease activity	Gains
HAZTE	GO:0004095	carnitine O-palmitoyltransferase activity	Gains
HAZTE	GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
HAZTE	GO:0004995	tachykinin receptor activity	Gains
HAZTE	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Gains
HAZTE	GO:0004044	amidophosphoribosyltransferase activity	Gains
HAZTE	GO:0004950	chemokine receptor activity	Gains
HAZTE	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Gains
HAZTE	GO:0009055	electron transfer activity	Gains
HAZTE	GO:0034061	DNA polymerase activity	Gains
HAZTE	GO:0022836	gated channel activity	Gains
HAZTE	GO:0004300	enoyl-CoA hydratase activity	Gains
HAZTE	GO:0003676	nucleic acid binding	Losses
HAZTE	GO:0008270	zinc ion binding	Losses
HAZTE	GO:0046914	transition metal ion binding	Losses
HAZTE	GO:0004984	olfactory receptor activity	Losses
HAZTE	GO:0003677	DNA binding	Losses
HAZTE	GO:0015631	tubulin binding	Losses
HAZTE	GO:0031409	pigment binding	Losses
HAZTE	GO:0043015	gamma-tubulin binding	Losses
HAZTE	GO:0046872	metal ion binding	Losses
HAZTE	GO:0008047	enzyme activator activity	Losses
HAZTE	GO:0043169	cation binding	Losses
HAZTE	GO:0008234	cysteine-type peptidase activity	Losses
HAZTE	GO:0008017	microtubule binding	Losses
HAZTE	GO:0101005	ubiquitinyl hydrolase activity	Losses
HAZTE	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
HAZTE	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
HAZTE	GO:0019783	ubiquitin-like protein-specific protease activity	Losses
HAZTE	GO:0051020	GTPase binding	Losses
HAZTE	GO:0017016	Ras GTPase binding	Losses
HAZTE	GO:0060589	nucleoside-triphosphatase regulator activity	Losses
HAZTE	GO:0008190	eukaryotic initiation factor 4E binding	Losses
HAZTE	GO:0005549	odorant binding	Losses
HAZTE	GO:0031267	small GTPase binding	Losses
HAZTE	GO:0004803	transposase activity	Losses
HAZTE	GO:0030695	GTPase regulator activity	Losses
HAZTE	GO:0008066	glutamate receptor activity	Losses
HAZTE	GO:0030246	carbohydrate binding	Losses
HAZTE	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
HAZTE	GO:0036081	extracellular ammonia-gated ion channel activity	Losses
HAZTE	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
HAZTE	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
HAZTE	GO:0005096	GTPase activator activity	Losses
HAZTE	GO:0022824	transmitter-gated ion channel activity	Losses
HAZTE	GO:0022835	transmitter-gated channel activity	Losses
HAZTE	GO:0005272	sodium channel activity	Losses
HAZTE	GO:0004970	ionotropic glutamate receptor activity	Losses
HAZTE	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
HAZTE	GO:0019840	isoprenoid binding	Losses
HAZTE	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
HAZTE	GO:0005319	lipid transporter activity	Losses
HAZTE	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
HAZTE	GO:0098772	molecular function regulator	Losses
HAZTE	GO:0008233	peptidase activity	Losses
HAZTE	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
HAZTE	GO:0061133	endopeptidase activator activity	Losses
HAZTE	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
HAZTE	GO:0051032	nucleic acid transmembrane transporter activity	Losses
HAZTE	GO:0051033	RNA transmembrane transporter activity	Losses
HAZTE	GO:0043874	acireductone synthase activity	Losses
HAZTE	GO:0030546	receptor activator activity	Losses
HAZTE	GO:0004555	alpha,alpha-trehalase activity	Losses
HAZTE	GO:0005500	juvenile hormone binding	Losses
HAZTE	GO:0008967	phosphoglycolate phosphatase activity	Losses
HAZTE	GO:0015927	trehalase activity	Losses
HAZTE	GO:0050591	quinine 3-monooxygenase activity	Losses
HAZTE	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
HAZTE	GO:0005488	binding	Losses
HAZTE	GO:0003676	nucleic acid binding	Extinctions
HAZTE	GO:0015631	tubulin binding	Extinctions
HAZTE	GO:0008047	enzyme activator activity	Extinctions
HAZTE	GO:0008234	cysteine-type peptidase activity	Extinctions
HAZTE	GO:0008017	microtubule binding	Extinctions
HAZTE	GO:0008190	eukaryotic initiation factor 4E binding	Extinctions
HAZTE	GO:0005272	sodium channel activity	Extinctions
HAZTE	GO:0008270	zinc ion binding	Extinctions
HAZTE	GO:0060589	nucleoside-triphosphatase regulator activity	Extinctions
HAZTE	GO:0046914	transition metal ion binding	Extinctions
HAZTE	GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
HAZTE	GO:0017016	Ras GTPase binding	Extinctions
HAZTE	GO:0008066	glutamate receptor activity	Extinctions
HAZTE	GO:0031267	small GTPase binding	Extinctions
HAZTE	GO:0004197	cysteine-type endopeptidase activity	Extinctions
HAZTE	GO:0030695	GTPase regulator activity	Extinctions
HAZTE	GO:0003677	DNA binding	Extinctions
HAZTE	GO:0031409	pigment binding	Extinctions
HAZTE	GO:0019840	isoprenoid binding	Extinctions
HAZTE	GO:0043015	gamma-tubulin binding	Extinctions
HAZTE	GO:0051020	GTPase binding	Extinctions
HAZTE	GO:0004984	olfactory receptor activity	Extinctions
HAZTE	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
HAZTE	GO:0022824	transmitter-gated ion channel activity	Extinctions
HAZTE	GO:0022835	transmitter-gated channel activity	Extinctions
HAZTE	GO:0004970	ionotropic glutamate receptor activity	Extinctions
HAZTE	GO:0008289	lipid binding	Extinctions
HAZTE	GO:0061133	endopeptidase activator activity	Extinctions
HAZTE	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
HAZTE	GO:0030546	receptor activator activity	Extinctions
HAZTE	GO:0005500	juvenile hormone binding	Extinctions
HAZTE	GO:0008967	phosphoglycolate phosphatase activity	Extinctions
HAZTE	GO:0005096	GTPase activator activity	Extinctions
HAZTE	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
HAZTE	GO:0017137	Rab GTPase binding	Extinctions
HAZTE	GO:0003743	translation initiation factor activity	Extinctions
HAZTE	GO:0008199	ferric iron binding	Extinctions
HAZTE	GO:0046872	metal ion binding	Extinctions
HAZTE	GO:0030246	carbohydrate binding	Extinctions
HAZTE	GO:0061135	endopeptidase regulator activity	Extinctions
HAZTE	GO:0043169	cation binding	Extinctions
LHUMI	GO:0038023	signaling receptor activity	Gains
LHUMI	GO:0099600	transmembrane receptor activity	Gains
LHUMI	GO:0004888	transmembrane signaling receptor activity	Gains
LHUMI	GO:0060089	molecular transducer activity	Gains
LHUMI	GO:0004930	G-protein coupled receptor activity	Gains
LHUMI	GO:0004984	olfactory receptor activity	Gains
LHUMI	GO:0004872	receptor activity	Gains
LHUMI	GO:0005549	odorant binding	Gains
LHUMI	GO:0004871	signal transducer activity	Gains
LHUMI	GO:0008270	zinc ion binding	Gains
LHUMI	GO:0070001	aspartic-type peptidase activity	Gains
LHUMI	GO:0004190	aspartic-type endopeptidase activity	Gains
LHUMI	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
LHUMI	GO:0046914	transition metal ion binding	Gains
LHUMI	GO:0030551	cyclic nucleotide binding	Gains
LHUMI	GO:0004692	cGMP-dependent protein kinase activity	Gains
LHUMI	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Gains
LHUMI	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
LHUMI	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
LHUMI	GO:0016872	intramolecular lyase activity	Gains
LHUMI	GO:0030553	cGMP binding	Gains
LHUMI	GO:0005212	structural constituent of eye lens	Gains
LHUMI	GO:0005500	juvenile hormone binding	Gains
LHUMI	GO:0004512	inositol-3-phosphate synthase activity	Gains
LHUMI	GO:0005080	protein kinase C binding	Gains
LHUMI	GO:0046872	metal ion binding	Gains
LHUMI	GO:0003964	RNA-directed DNA polymerase activity	Gains
LHUMI	GO:0003676	nucleic acid binding	Gains
LHUMI	GO:0043169	cation binding	Gains
LHUMI	GO:0008329	signaling pattern recognition receptor activity	Gains
LHUMI	GO:0038187	pattern recognition receptor activity	Gains
LHUMI	GO:0022843	voltage-gated cation channel activity	Gains
LHUMI	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
LHUMI	GO:0004175	endopeptidase activity	Gains
LHUMI	GO:0008527	taste receptor activity	Gains
LHUMI	GO:0005509	calcium ion binding	Gains
LHUMI	GO:0050254	rhodopsin kinase activity	Gains
LHUMI	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
LHUMI	GO:0004144	diacylglycerol O-acyltransferase activity	Gains
LHUMI	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	Gains
LHUMI	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
LHUMI	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
LHUMI	GO:0008233	peptidase activity	Gains
LHUMI	GO:0003964	RNA-directed DNA polymerase activity	Losses
LHUMI	GO:0034061	DNA polymerase activity	Losses
LHUMI	GO:0140097	catalytic activity, acting on DNA	Losses
LHUMI	GO:0016779	nucleotidyltransferase activity	Losses
LHUMI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
LHUMI	GO:0004519	endonuclease activity	Losses
LHUMI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
LHUMI	GO:0004521	endoribonuclease activity	Losses
LHUMI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
LHUMI	GO:0070001	aspartic-type peptidase activity	Losses
LHUMI	GO:0004190	aspartic-type endopeptidase activity	Losses
LHUMI	GO:0004518	nuclease activity	Losses
LHUMI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
LHUMI	GO:0003723	RNA binding	Losses
LHUMI	GO:0003676	nucleic acid binding	Losses
LHUMI	GO:0015002	heme-copper terminal oxidase activity	Losses
LHUMI	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
LHUMI	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
LHUMI	GO:0004129	cytochrome-c oxidase activity	Losses
LHUMI	GO:0046914	transition metal ion binding	Losses
LHUMI	GO:0008270	zinc ion binding	Losses
LHUMI	GO:0004540	ribonuclease activity	Losses
LHUMI	GO:1901363	heterocyclic compound binding	Losses
LHUMI	GO:0097159	organic cyclic compound binding	Losses
LHUMI	GO:0003677	DNA binding	Losses
LHUMI	GO:0009055	electron transfer activity	Losses
LHUMI	GO:0046872	metal ion binding	Losses
LHUMI	GO:0004984	olfactory receptor activity	Losses
LHUMI	GO:0043169	cation binding	Losses
LHUMI	GO:0016803	ether hydrolase activity	Losses
LHUMI	GO:0016740	transferase activity	Losses
LHUMI	GO:0016801	hydrolase activity, acting on ether bonds	Losses
LHUMI	GO:0004602	glutathione peroxidase activity	Losses
LHUMI	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
LHUMI	GO:0004601	peroxidase activity	Losses
LHUMI	GO:0140098	catalytic activity, acting on RNA	Losses
LHUMI	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
LHUMI	GO:0005549	odorant binding	Losses
LHUMI	GO:0004364	glutathione transferase activity	Losses
LHUMI	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
LHUMI	GO:0038024	cargo receptor activity	Losses
LHUMI	GO:0003678	DNA helicase activity	Losses
LHUMI	GO:0009881	photoreceptor activity	Losses
LHUMI	GO:0008527	taste receptor activity	Losses
LHUMI	GO:0016788	hydrolase activity, acting on ester bonds	Losses
LHUMI	GO:0004803	transposase activity	Losses
LHUMI	GO:0004020	adenylylsulfate kinase activity	Losses
LHUMI	GO:0004034	aldose 1-epimerase activity	Losses
LHUMI	GO:1900750	oligopeptide binding	Losses
LHUMI	GO:0008196	vitellogenin receptor activity	Losses
LHUMI	GO:0017159	pantetheine hydrolase activity	Losses
LHUMI	GO:0008160	protein tyrosine phosphatase activator activity	Losses
LHUMI	GO:0005125	cytokine activity	Losses
LHUMI	GO:0004301	epoxide hydrolase activity	Losses
LHUMI	GO:0043295	glutathione binding	Losses
LHUMI	GO:0019211	phosphatase activator activity	Losses
LHUMI	GO:0051721	protein phosphatase 2A binding	Losses
LHUMI	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
LHUMI	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
LHUMI	GO:0051538	3 iron, 4 sulfur cluster binding	Losses
LHUMI	GO:0097493	structural molecule activity conferring elasticity	Losses
LHUMI	GO:0004587	ornithine-oxo-acid transaminase activity	Losses
LHUMI	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
LHUMI	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
LHUMI	GO:0004667	prostaglandin-D synthase activity	Losses
LHUMI	GO:0072542	protein phosphatase activator activity	Losses
LHUMI	GO:0005034	osmosensor activity	Losses
LHUMI	GO:0016209	antioxidant activity	Losses
LHUMI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
LHUMI	GO:0008233	peptidase activity	Losses
LHUMI	GO:0099600	transmembrane receptor activity	Losses
LHUMI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
LHUMI	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
LHUMI	GO:0005488	binding	Losses
LHUMI	GO:0003887	DNA-directed DNA polymerase activity	Losses
LHUMI	GO:0004175	endopeptidase activity	Losses
LHUMI	GO:0008177	succinate dehydrogenase (ubiquinone) activity	Losses
LHUMI	GO:0015927	trehalase activity	Losses
LHUMI	GO:0004371	glycerone kinase activity	Losses
LHUMI	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Losses
LHUMI	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
LHUMI	GO:0004555	alpha,alpha-trehalase activity	Losses
LHUMI	GO:0050591	quinine 3-monooxygenase activity	Losses
LHUMI	GO:0003933	GTP cyclohydrolase activity	Losses
LHUMI	GO:0003934	GTP cyclohydrolase I activity	Losses
LHUMI	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
LHUMI	GO:0043023	ribosomal large subunit binding	Losses
LHUMI	GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
LHUMI	GO:0048039	ubiquinone binding	Losses
LHUMI	GO:0005201	extracellular matrix structural constituent	Losses
LHUMI	GO:0003954	NADH dehydrogenase activity	Losses
LHUMI	GO:0004888	transmembrane signaling receptor activity	Losses
LHUMI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
LHUMI	GO:0034061	DNA polymerase activity	Extinctions
LHUMI	GO:0140097	catalytic activity, acting on DNA	Extinctions
LHUMI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
LHUMI	GO:0015002	heme-copper terminal oxidase activity	Extinctions
LHUMI	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
LHUMI	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
LHUMI	GO:0004129	cytochrome-c oxidase activity	Extinctions
LHUMI	GO:0016779	nucleotidyltransferase activity	Extinctions
LHUMI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
LHUMI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
LHUMI	GO:0004518	nuclease activity	Extinctions
LHUMI	GO:0004519	endonuclease activity	Extinctions
LHUMI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
LHUMI	GO:0003678	DNA helicase activity	Extinctions
LHUMI	GO:0004521	endoribonuclease activity	Extinctions
LHUMI	GO:0009055	electron transfer activity	Extinctions
LHUMI	GO:0009881	photoreceptor activity	Extinctions
LHUMI	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
LHUMI	GO:0004540	ribonuclease activity	Extinctions
LHUMI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
LHUMI	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
LHUMI	GO:0003676	nucleic acid binding	Extinctions
LHUMI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
LHUMI	GO:0003954	NADH dehydrogenase activity	Extinctions
LHUMI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
LHUMI	GO:1901363	heterocyclic compound binding	Extinctions
LHUMI	GO:0097159	organic cyclic compound binding	Extinctions
LHUMI	GO:1900750	oligopeptide binding	Extinctions
LHUMI	GO:0008196	vitellogenin receptor activity	Extinctions
LHUMI	GO:0017159	pantetheine hydrolase activity	Extinctions
LHUMI	GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
LHUMI	GO:0043295	glutathione binding	Extinctions
LHUMI	GO:0019211	phosphatase activator activity	Extinctions
LHUMI	GO:0051721	protein phosphatase 2A binding	Extinctions
LHUMI	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
LHUMI	GO:0072542	protein phosphatase activator activity	Extinctions
LHUMI	GO:0005034	osmosensor activity	Extinctions
LHUMI	GO:0004386	helicase activity	Extinctions
LHUMI	GO:0070001	aspartic-type peptidase activity	Extinctions
LHUMI	GO:0004190	aspartic-type endopeptidase activity	Extinctions
LHUMI	GO:0099600	transmembrane receptor activity	Extinctions
LHUMI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
LHUMI	GO:0004371	glycerone kinase activity	Extinctions
LHUMI	GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
LHUMI	GO:0050591	quinine 3-monooxygenase activity	Extinctions
LHUMI	GO:0003933	GTP cyclohydrolase activity	Extinctions
LHUMI	GO:0003934	GTP cyclohydrolase I activity	Extinctions
LHUMI	GO:0038024	cargo receptor activity	Extinctions
LHUMI	GO:0004888	transmembrane signaling receptor activity	Extinctions
LHUMI	GO:0004447	iodide peroxidase activity	Extinctions
LHUMI	GO:0071855	neuropeptide receptor binding	Extinctions
LHUMI	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
LHUMI	GO:0060089	molecular transducer activity	Extinctions
LHUMI	GO:0019238	cyclohydrolase activity	Extinctions
LHUMI	GO:0034450	ubiquitin-ubiquitin ligase activity	Extinctions
LHUMI	GO:0061659	ubiquitin-like protein ligase activity	Extinctions
LHUMI	GO:0061630	ubiquitin protein ligase activity	Extinctions
LHUMI	GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
AGAMB	GO:0005549	odorant binding	Gains
AGAMB	GO:0004984	olfactory receptor activity	Gains
AGAMB	GO:0017171	serine hydrolase activity	Gains
AGAMB	GO:0008236	serine-type peptidase activity	Gains
AGAMB	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
AGAMB	GO:0004252	serine-type endopeptidase activity	Gains
AGAMB	GO:0016491	oxidoreductase activity	Gains
AGAMB	GO:0004175	endopeptidase activity	Gains
AGAMB	GO:0004497	monooxygenase activity	Gains
AGAMB	GO:0042834	peptidoglycan binding	Gains
AGAMB	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
AGAMB	GO:0070330	aromatase activity	Gains
AGAMB	GO:0008233	peptidase activity	Gains
AGAMB	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
AGAMB	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
AGAMB	GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
AGAMB	GO:0004462	lactoylglutathione lyase activity	Gains
AGAMB	GO:0004601	peroxidase activity	Gains
AGAMB	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
AGAMB	GO:0004602	glutathione peroxidase activity	Gains
AGAMB	GO:0016801	hydrolase activity, acting on ether bonds	Gains
AGAMB	GO:0016755	transferase activity, transferring amino-acyl groups	Gains
AGAMB	GO:0016803	ether hydrolase activity	Gains
AGAMB	GO:0008171	O-methyltransferase activity	Gains
AGAMB	GO:0016757	transferase activity, transferring glycosyl groups	Gains
AGAMB	GO:0005215	transporter activity	Gains
AGAMB	GO:0005506	iron ion binding	Gains
AGAMB	GO:0035250	UDP-galactosyltransferase activity	Gains
AGAMB	GO:0004930	G-protein coupled receptor activity	Gains
AGAMB	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
AGAMB	GO:0005501	retinoid binding	Gains
AGAMB	GO:0001530	lipopolysaccharide binding	Gains
AGAMB	GO:0008329	signaling pattern recognition receptor activity	Gains
AGAMB	GO:0038187	pattern recognition receptor activity	Gains
AGAMB	GO:0016746	transferase activity, transferring acyl groups	Gains
AGAMB	GO:0038023	signaling receptor activity	Gains
AGAMB	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Gains
AGAMB	GO:0030246	carbohydrate binding	Gains
AGAMB	GO:0004568	chitinase activity	Gains
AGAMB	GO:0099600	transmembrane receptor activity	Gains
AGAMB	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
AGAMB	GO:0015141	succinate transmembrane transporter activity	Gains
AGAMB	GO:0015288	porin activity	Gains
AGAMB	GO:0001872	(1->3)-beta-D-glucan binding	Gains
AGAMB	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
AGAMB	GO:0050591	quinine 3-monooxygenase activity	Gains
AGAMB	GO:0018685	alkane 1-monooxygenase activity	Gains
AGAMB	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
AGAMB	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
AGAMB	GO:0004033	aldo-keto reductase (NADP) activity	Gains
AGAMB	GO:0008336	gamma-butyrobetaine dioxygenase activity	Gains
AGAMB	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
AGAMB	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
AGAMB	GO:0005212	structural constituent of eye lens	Gains
AGAMB	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
AGAMB	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
AGAMB	GO:0004344	glucose dehydrogenase activity	Gains
AGAMB	GO:0051213	dioxygenase activity	Gains
AGAMB	GO:0016209	antioxidant activity	Gains
AGAMB	GO:0004888	transmembrane signaling receptor activity	Gains
AGAMB	GO:0048029	monosaccharide binding	Gains
AGAMB	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
AGAMB	GO:0008378	galactosyltransferase activity	Gains
AGAMB	GO:0004312	fatty acid synthase activity	Gains
AGAMB	GO:0004872	receptor activity	Gains
AGAMB	GO:0001871	pattern binding	Gains
AGAMB	GO:0030247	polysaccharide binding	Gains
AGAMB	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
AGAMB	GO:0019840	isoprenoid binding	Gains
AGAMB	GO:0008812	choline dehydrogenase activity	Gains
AGAMB	GO:0020037	heme binding	Gains
AGAMB	GO:0004180	carboxypeptidase activity	Gains
AGAMB	GO:0016763	transferase activity, transferring pentosyl groups	Gains
AGAMB	GO:0046906	tetrapyrrole binding	Gains
AGAMB	GO:0008238	exopeptidase activity	Gains
AGAMB	GO:0030414	peptidase inhibitor activity	Gains
AGAMB	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
AGAMB	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
AGAMB	GO:0060089	molecular transducer activity	Gains
AGAMB	GO:0005201	extracellular matrix structural constituent	Gains
AGAMB	GO:0050113	inositol oxygenase activity	Gains
AGAMB	GO:0070891	lipoteichoic acid binding	Gains
AGAMB	GO:0009922	fatty acid elongase activity	Gains
AGAMB	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Gains
AGAMB	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Gains
AGAMB	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Gains
AGAMB	GO:0004617	phosphoglycerate dehydrogenase activity	Gains
AGAMB	GO:0030882	lipid antigen binding	Gains
AGAMB	GO:0008410	CoA-transferase activity	Gains
AGAMB	GO:0050321	tau-protein kinase activity	Gains
AGAMB	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
AGAMB	GO:0022857	transmembrane transporter activity	Gains
AGAMB	GO:0015291	secondary active transmembrane transporter activity	Gains
AGAMB	GO:0008079	translation termination factor activity	Gains
AGAMB	GO:0004622	lysophospholipase activity	Gains
AGAMB	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	Gains
AGAMB	GO:0016846	carbon-sulfur lyase activity	Gains
AGAMB	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
AGAMB	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
AGAMB	GO:0003747	translation release factor activity	Gains
AGAMB	GO:0003964	RNA-directed DNA polymerase activity	Losses
AGAMB	GO:0003700	DNA binding transcription factor activity	Losses
AGAMB	GO:0034061	DNA polymerase activity	Losses
AGAMB	GO:0043565	sequence-specific DNA binding	Losses
AGAMB	GO:0140110	transcription regulator activity	Losses
AGAMB	GO:0003677	DNA binding	Losses
AGAMB	GO:0005249	voltage-gated potassium channel activity	Losses
AGAMB	GO:0140097	catalytic activity, acting on DNA	Losses
AGAMB	GO:0099600	transmembrane receptor activity	Losses
AGAMB	GO:0022836	gated channel activity	Losses
AGAMB	GO:0004871	signal transducer activity	Losses
AGAMB	GO:0016779	nucleotidyltransferase activity	Losses
AGAMB	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
AGAMB	GO:0005267	potassium channel activity	Losses
AGAMB	GO:0015079	potassium ion transmembrane transporter activity	Losses
AGAMB	GO:0022843	voltage-gated cation channel activity	Losses
AGAMB	GO:0038023	signaling receptor activity	Losses
AGAMB	GO:0004888	transmembrane signaling receptor activity	Losses
AGAMB	GO:0004872	receptor activity	Losses
AGAMB	GO:0060089	molecular transducer activity	Losses
AGAMB	GO:0070001	aspartic-type peptidase activity	Losses
AGAMB	GO:0004190	aspartic-type endopeptidase activity	Losses
AGAMB	GO:0022832	voltage-gated channel activity	Losses
AGAMB	GO:0005244	voltage-gated ion channel activity	Losses
AGAMB	GO:0005216	ion channel activity	Losses
AGAMB	GO:0022838	substrate-specific channel activity	Losses
AGAMB	GO:0015267	channel activity	Losses
AGAMB	GO:0022803	passive transmembrane transporter activity	Losses
AGAMB	GO:0004930	G-protein coupled receptor activity	Losses
AGAMB	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
AGAMB	GO:0003676	nucleic acid binding	Losses
AGAMB	GO:0008146	sulfotransferase activity	Losses
AGAMB	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
AGAMB	GO:0005261	cation channel activity	Losses
AGAMB	GO:0015276	ligand-gated ion channel activity	Losses
AGAMB	GO:0022834	ligand-gated channel activity	Losses
AGAMB	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
AGAMB	GO:0004935	adrenergic receptor activity	Losses
AGAMB	GO:0017048	Rho GTPase binding	Losses
AGAMB	GO:0005509	calcium ion binding	Losses
AGAMB	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
AGAMB	GO:0046872	metal ion binding	Losses
AGAMB	GO:0005085	guanyl-nucleotide exchange factor activity	Losses
AGAMB	GO:0008270	zinc ion binding	Losses
AGAMB	GO:0043169	cation binding	Losses
AGAMB	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
AGAMB	GO:0005230	extracellular ligand-gated ion channel activity	Losses
AGAMB	GO:0046873	metal ion transmembrane transporter activity	Losses
AGAMB	GO:0008528	G-protein coupled peptide receptor activity	Losses
AGAMB	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
AGAMB	GO:0008227	G-protein coupled amine receptor activity	Losses
AGAMB	GO:0001653	peptide receptor activity	Losses
AGAMB	GO:0004519	endonuclease activity	Losses
AGAMB	GO:1990837	sequence-specific double-stranded DNA binding	Losses
AGAMB	GO:0015368	calcium:cation antiporter activity	Losses
AGAMB	GO:0005251	delayed rectifier potassium channel activity	Losses
AGAMB	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
AGAMB	GO:0004713	protein tyrosine kinase activity	Losses
AGAMB	GO:0044212	transcription regulatory region DNA binding	Losses
AGAMB	GO:0016782	transferase activity, transferring sulfur-containing groups	Losses
AGAMB	GO:0001067	regulatory region nucleic acid binding	Losses
AGAMB	GO:0000975	regulatory region DNA binding	Losses
AGAMB	GO:0008237	metallopeptidase activity	Losses
AGAMB	GO:0004672	protein kinase activity	Losses
AGAMB	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
AGAMB	GO:0008241	peptidyl-dipeptidase activity	Losses
AGAMB	GO:0004222	metalloendopeptidase activity	Losses
AGAMB	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
AGAMB	GO:0070851	growth factor receptor binding	Losses
AGAMB	GO:0004518	nuclease activity	Losses
AGAMB	GO:0016301	kinase activity	Losses
AGAMB	GO:0003690	double-stranded DNA binding	Losses
AGAMB	GO:0008201	heparin binding	Losses
AGAMB	GO:0003678	DNA helicase activity	Losses
AGAMB	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AGAMB	GO:0034061	DNA polymerase activity	Extinctions
AGAMB	GO:0003700	DNA binding transcription factor activity	Extinctions
AGAMB	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
AGAMB	GO:0140097	catalytic activity, acting on DNA	Extinctions
AGAMB	GO:0003677	DNA binding	Extinctions
AGAMB	GO:0140110	transcription regulator activity	Extinctions
AGAMB	GO:0016779	nucleotidyltransferase activity	Extinctions
AGAMB	GO:0043565	sequence-specific DNA binding	Extinctions
AGAMB	GO:0005249	voltage-gated potassium channel activity	Extinctions
AGAMB	GO:0022836	gated channel activity	Extinctions
AGAMB	GO:0005267	potassium channel activity	Extinctions
AGAMB	GO:0022843	voltage-gated cation channel activity	Extinctions
AGAMB	GO:0015079	potassium ion transmembrane transporter activity	Extinctions
AGAMB	GO:0070001	aspartic-type peptidase activity	Extinctions
AGAMB	GO:0004190	aspartic-type endopeptidase activity	Extinctions
AGAMB	GO:0022832	voltage-gated channel activity	Extinctions
AGAMB	GO:0005244	voltage-gated ion channel activity	Extinctions
AGAMB	GO:0004519	endonuclease activity	Extinctions
AGAMB	GO:0003676	nucleic acid binding	Extinctions
AGAMB	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
AGAMB	GO:0008146	sulfotransferase activity	Extinctions
AGAMB	GO:0005509	calcium ion binding	Extinctions
AGAMB	GO:0005085	guanyl-nucleotide exchange factor activity	Extinctions
AGAMB	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Extinctions
AGAMB	GO:0004518	nuclease activity	Extinctions
AGAMB	GO:0017048	Rho GTPase binding	Extinctions
AGAMB	GO:0005216	ion channel activity	Extinctions
AGAMB	GO:0022838	substrate-specific channel activity	Extinctions
AGAMB	GO:0015267	channel activity	Extinctions
AGAMB	GO:0022803	passive transmembrane transporter activity	Extinctions
AGAMB	GO:0004871	signal transducer activity	Extinctions
AGAMB	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
AGAMB	GO:0046872	metal ion binding	Extinctions
AGAMB	GO:0043169	cation binding	Extinctions
AGAMB	GO:0099600	transmembrane receptor activity	Extinctions
AGAMB	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Extinctions
AGAMB	GO:0004521	endoribonuclease activity	Extinctions
AGAMB	GO:0004930	G-protein coupled receptor activity	Extinctions
AGAMB	GO:0051020	GTPase binding	Extinctions
AGAMB	GO:0070851	growth factor receptor binding	Extinctions
AGAMB	GO:0008270	zinc ion binding	Extinctions
AGAMB	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
AGAMB	GO:0004540	ribonuclease activity	Extinctions
AGAMB	GO:0016782	transferase activity, transferring sulfur-containing groups	Extinctions
AGAMB	GO:0004888	transmembrane signaling receptor activity	Extinctions
AGAMB	GO:0038023	signaling receptor activity	Extinctions
AGAMB	GO:0071859	neuropeptide F receptor binding	Extinctions
AGAMB	GO:0005104	fibroblast growth factor receptor binding	Extinctions
AGAMB	GO:0005261	cation channel activity	Extinctions
AECHI	GO:0034061	DNA polymerase activity	Gains
AECHI	GO:0140097	catalytic activity, acting on DNA	Gains
AECHI	GO:0003964	RNA-directed DNA polymerase activity	Gains
AECHI	GO:0016779	nucleotidyltransferase activity	Gains
AECHI	GO:0004190	aspartic-type endopeptidase activity	Gains
AECHI	GO:0070001	aspartic-type peptidase activity	Gains
AECHI	GO:0003963	RNA-3'-phosphate cyclase activity	Gains
AECHI	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
AECHI	GO:0003735	structural constituent of ribosome	Gains
AECHI	GO:0004803	transposase activity	Gains
AECHI	GO:0005198	structural molecule activity	Gains
AECHI	GO:0004175	endopeptidase activity	Gains
AECHI	GO:0003676	nucleic acid binding	Gains
AECHI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
AECHI	GO:0008237	metallopeptidase activity	Gains
AECHI	GO:0008527	taste receptor activity	Gains
AECHI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Gains
AECHI	GO:0008233	peptidase activity	Gains
AECHI	GO:0005507	copper ion binding	Gains
AECHI	GO:0004930	G-protein coupled receptor activity	Gains
AECHI	GO:0004364	glutathione transferase activity	Gains
AECHI	GO:0016247	channel regulator activity	Gains
AECHI	GO:0016886	ligase activity, forming phosphoric ester bonds	Gains
AECHI	GO:0016763	transferase activity, transferring pentosyl groups	Gains
AECHI	GO:0015250	water channel activity	Gains
AECHI	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
AECHI	GO:0005159	insulin-like growth factor receptor binding	Gains
AECHI	GO:0016361	activin receptor activity, type I	Gains
AECHI	GO:0004351	glutamate decarboxylase activity	Gains
AECHI	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity	Gains
AECHI	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	Gains
AECHI	GO:0018833	DDT-dehydrochlorinase activity	Gains
AECHI	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
AECHI	GO:0004170	dUTP diphosphatase activity	Gains
AECHI	GO:0004145	diamine N-acetyltransferase activity	Gains
AECHI	GO:0080007	S-nitrosoglutathione reductase activity	Gains
AECHI	GO:0004798	thymidylate kinase activity	Gains
AECHI	GO:0004782	sulfinoalanine decarboxylase activity	Gains
AECHI	GO:0050431	transforming growth factor beta binding	Gains
AECHI	GO:0004552	octanol dehydrogenase activity	Gains
AECHI	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Gains
AECHI	GO:0004516	nicotinate phosphoribosyltransferase activity	Gains
AECHI	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Gains
AECHI	GO:0070122	isopeptidase activity	Gains
AECHI	GO:0070140	SUMO-specific isopeptidase activity	Gains
AECHI	GO:0005025	transforming growth factor beta receptor activity, type I	Gains
AECHI	GO:0070138	ubiquitin-like protein-specific isopeptidase activity	Gains
AECHI	GO:0008949	oxalyl-CoA decarboxylase activity	Gains
AECHI	GO:0061598	molybdopterin adenylyltransferase activity	Gains
AECHI	GO:0061599	molybdopterin molybdotransferase activity	Gains
AECHI	GO:0042736	NADH kinase activity	Gains
AECHI	GO:0004068	aspartate 1-decarboxylase activity	Gains
AECHI	GO:0042806	fucose binding	Gains
AECHI	GO:0005372	water transmembrane transporter activity	Gains
AECHI	GO:0016936	galactoside binding	Gains
AECHI	GO:0043273	CTPase activity	Gains
AECHI	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Gains
AECHI	GO:0030414	peptidase inhibitor activity	Gains
AECHI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
AECHI	GO:1901363	heterocyclic compound binding	Gains
AECHI	GO:0003887	DNA-directed DNA polymerase activity	Gains
AECHI	GO:0097159	organic cyclic compound binding	Gains
AECHI	GO:0004222	metalloendopeptidase activity	Gains
AECHI	GO:0003964	RNA-directed DNA polymerase activity	Losses
AECHI	GO:0034061	DNA polymerase activity	Losses
AECHI	GO:0140097	catalytic activity, acting on DNA	Losses
AECHI	GO:0016779	nucleotidyltransferase activity	Losses
AECHI	GO:0022836	gated channel activity	Losses
AECHI	GO:0005549	odorant binding	Losses
AECHI	GO:0005216	ion channel activity	Losses
AECHI	GO:0022838	substrate-specific channel activity	Losses
AECHI	GO:0038023	signaling receptor activity	Losses
AECHI	GO:0015267	channel activity	Losses
AECHI	GO:0022803	passive transmembrane transporter activity	Losses
AECHI	GO:0099600	transmembrane receptor activity	Losses
AECHI	GO:0004872	receptor activity	Losses
AECHI	GO:0060089	molecular transducer activity	Losses
AECHI	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
AECHI	GO:0022843	voltage-gated cation channel activity	Losses
AECHI	GO:0004871	signal transducer activity	Losses
AECHI	GO:0004984	olfactory receptor activity	Losses
AECHI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
AECHI	GO:0005261	cation channel activity	Losses
AECHI	GO:0004888	transmembrane signaling receptor activity	Losses
AECHI	GO:0015079	potassium ion transmembrane transporter activity	Losses
AECHI	GO:0005244	voltage-gated ion channel activity	Losses
AECHI	GO:0022832	voltage-gated channel activity	Losses
AECHI	GO:0005249	voltage-gated potassium channel activity	Losses
AECHI	GO:0004518	nuclease activity	Losses
AECHI	GO:0005267	potassium channel activity	Losses
AECHI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
AECHI	GO:0004519	endonuclease activity	Losses
AECHI	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
AECHI	GO:0004930	G-protein coupled receptor activity	Losses
AECHI	GO:0015075	ion transmembrane transporter activity	Losses
AECHI	GO:0015276	ligand-gated ion channel activity	Losses
AECHI	GO:0022834	ligand-gated channel activity	Losses
AECHI	GO:0003707	steroid hormone receptor activity	Losses
AECHI	GO:0015269	calcium-activated potassium channel activity	Losses
AECHI	GO:0008307	structural constituent of muscle	Losses
AECHI	GO:0003700	DNA binding transcription factor activity	Losses
AECHI	GO:0043565	sequence-specific DNA binding	Losses
AECHI	GO:0004190	aspartic-type endopeptidase activity	Losses
AECHI	GO:0070001	aspartic-type peptidase activity	Losses
AECHI	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
AECHI	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
AECHI	GO:0052834	inositol monophosphate phosphatase activity	Losses
AECHI	GO:0005080	protein kinase C binding	Losses
AECHI	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
AECHI	GO:0022857	transmembrane transporter activity	Losses
AECHI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
AECHI	GO:0005227	calcium activated cation channel activity	Losses
AECHI	GO:0046873	metal ion transmembrane transporter activity	Losses
AECHI	GO:0005230	extracellular ligand-gated ion channel activity	Losses
AECHI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
AECHI	GO:0003676	nucleic acid binding	Losses
AECHI	GO:0022891	substrate-specific transmembrane transporter activity	Losses
AECHI	GO:0022839	ion gated channel activity	Losses
AECHI	GO:0005509	calcium ion binding	Losses
AECHI	GO:0004521	endoribonuclease activity	Losses
AECHI	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
AECHI	GO:0004950	chemokine receptor activity	Losses
AECHI	GO:0005262	calcium channel activity	Losses
AECHI	GO:0022890	inorganic cation transmembrane transporter activity	Losses
AECHI	GO:0008324	cation transmembrane transporter activity	Losses
AECHI	GO:0022892	substrate-specific transporter activity	Losses
AECHI	GO:0035173	histone kinase activity	Losses
AECHI	GO:0005217	intracellular ligand-gated ion channel activity	Losses
AECHI	GO:0004736	pyruvate carboxylase activity	Losses
AECHI	GO:0004896	cytokine receptor activity	Losses
AECHI	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Losses
AECHI	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
AECHI	GO:0052745	inositol phosphate phosphatase activity	Losses
AECHI	GO:0003677	DNA binding	Losses
AECHI	GO:0008134	transcription factor binding	Losses
AECHI	GO:0004540	ribonuclease activity	Losses
AECHI	GO:0140110	transcription regulator activity	Losses
AECHI	GO:0003777	microtubule motor activity	Losses
AECHI	GO:0015085	calcium ion transmembrane transporter activity	Losses
AECHI	GO:0004803	transposase activity	Losses
AECHI	GO:0008270	zinc ion binding	Losses
AECHI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
AECHI	GO:0034061	DNA polymerase activity	Extinctions
AECHI	GO:0140097	catalytic activity, acting on DNA	Extinctions
AECHI	GO:0016779	nucleotidyltransferase activity	Extinctions
AECHI	GO:0005549	odorant binding	Extinctions
AECHI	GO:0004984	olfactory receptor activity	Extinctions
AECHI	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
AECHI	GO:0004519	endonuclease activity	Extinctions
AECHI	GO:0060089	molecular transducer activity	Extinctions
AECHI	GO:0005216	ion channel activity	Extinctions
AECHI	GO:0022836	gated channel activity	Extinctions
AECHI	GO:0099600	transmembrane receptor activity	Extinctions
AECHI	GO:0022838	substrate-specific channel activity	Extinctions
AECHI	GO:0038023	signaling receptor activity	Extinctions
AECHI	GO:0015267	channel activity	Extinctions
AECHI	GO:0022803	passive transmembrane transporter activity	Extinctions
AECHI	GO:0003676	nucleic acid binding	Extinctions
AECHI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
AECHI	GO:0004872	receptor activity	Extinctions
AECHI	GO:0004518	nuclease activity	Extinctions
AECHI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
AECHI	GO:0004871	signal transducer activity	Extinctions
AECHI	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
AECHI	GO:0004888	transmembrane signaling receptor activity	Extinctions
AECHI	GO:0015276	ligand-gated ion channel activity	Extinctions
AECHI	GO:0022834	ligand-gated channel activity	Extinctions
AECHI	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
AECHI	GO:0008527	taste receptor activity	Extinctions
AECHI	GO:0004521	endoribonuclease activity	Extinctions
AECHI	GO:0005249	voltage-gated potassium channel activity	Extinctions
AECHI	GO:0005507	copper ion binding	Extinctions
AECHI	GO:0005267	potassium channel activity	Extinctions
AECHI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
AECHI	GO:0016597	amino acid binding	Extinctions
AECHI	GO:0004540	ribonuclease activity	Extinctions
AECHI	GO:0004930	G-protein coupled receptor activity	Extinctions
AECHI	GO:0005509	calcium ion binding	Extinctions
AECHI	GO:0015271	outward rectifier potassium channel activity	Extinctions
AECHI	GO:0033867	Fas-activated serine/threonine kinase activity	Extinctions
AECHI	GO:0005250	A-type (transient outward) potassium channel activity	Extinctions
AECHI	GO:0016532	superoxide dismutase copper chaperone activity	Extinctions
AECHI	GO:0016534	cyclin-dependent protein kinase 5 activator activity	Extinctions
AECHI	GO:0004679	AMP-activated protein kinase activity	Extinctions
AECHI	GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	Extinctions
AECHI	GO:0050897	cobalt ion binding	Extinctions
AECHI	GO:0004038	allantoinase activity	Extinctions
NVITR	GO:0003964	RNA-directed DNA polymerase activity	Gains
NVITR	GO:0034061	DNA polymerase activity	Gains
NVITR	GO:0004984	olfactory receptor activity	Gains
NVITR	GO:0005549	odorant binding	Gains
NVITR	GO:0140097	catalytic activity, acting on DNA	Gains
NVITR	GO:0038023	signaling receptor activity	Gains
NVITR	GO:0004888	transmembrane signaling receptor activity	Gains
NVITR	GO:0099600	transmembrane receptor activity	Gains
NVITR	GO:0016779	nucleotidyltransferase activity	Gains
NVITR	GO:0004872	receptor activity	Gains
NVITR	GO:0060089	molecular transducer activity	Gains
NVITR	GO:0004871	signal transducer activity	Gains
NVITR	GO:0004930	G-protein coupled receptor activity	Gains
NVITR	GO:0022824	transmitter-gated ion channel activity	Gains
NVITR	GO:0022835	transmitter-gated channel activity	Gains
NVITR	GO:0004970	ionotropic glutamate receptor activity	Gains
NVITR	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
NVITR	GO:0070001	aspartic-type peptidase activity	Gains
NVITR	GO:0004190	aspartic-type endopeptidase activity	Gains
NVITR	GO:0003676	nucleic acid binding	Gains
NVITR	GO:0008066	glutamate receptor activity	Gains
NVITR	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
NVITR	GO:0008270	zinc ion binding	Gains
NVITR	GO:0046914	transition metal ion binding	Gains
NVITR	GO:0030594	neurotransmitter receptor activity	Gains
NVITR	GO:0005230	extracellular ligand-gated ion channel activity	Gains
NVITR	GO:0004519	endonuclease activity	Gains
NVITR	GO:0004518	nuclease activity	Gains
NVITR	GO:0022834	ligand-gated channel activity	Gains
NVITR	GO:0015276	ligand-gated ion channel activity	Gains
NVITR	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
NVITR	GO:0003723	RNA binding	Gains
NVITR	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
NVITR	GO:0008233	peptidase activity	Gains
NVITR	GO:0022836	gated channel activity	Gains
NVITR	GO:0005216	ion channel activity	Gains
NVITR	GO:0032450	maltose alpha-glucosidase activity	Gains
NVITR	GO:0022838	substrate-specific channel activity	Gains
NVITR	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
NVITR	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
NVITR	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
NVITR	GO:0038187	pattern recognition receptor activity	Gains
NVITR	GO:0008329	signaling pattern recognition receptor activity	Gains
NVITR	GO:0022803	passive transmembrane transporter activity	Gains
NVITR	GO:0015267	channel activity	Gains
NVITR	GO:0003678	DNA helicase activity	Gains
NVITR	GO:0046872	metal ion binding	Gains
NVITR	GO:0043169	cation binding	Gains
NVITR	GO:0090599	alpha-glucosidase activity	Gains
NVITR	GO:0008527	taste receptor activity	Gains
NVITR	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
NVITR	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
NVITR	GO:0005024	transforming growth factor beta-activated receptor activity	Gains
NVITR	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
NVITR	GO:0004521	endoribonuclease activity	Gains
NVITR	GO:0004175	endopeptidase activity	Gains
NVITR	GO:0005214	structural constituent of chitin-based cuticle	Gains
NVITR	GO:0015926	glucosidase activity	Gains
NVITR	GO:0016788	hydrolase activity, acting on ester bonds	Gains
NVITR	GO:0030414	peptidase inhibitor activity	Gains
NVITR	GO:0016848	carbon-halide lyase activity	Gains
NVITR	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
NVITR	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Gains
NVITR	GO:0004503	monophenol monooxygenase activity	Gains
NVITR	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
NVITR	GO:0004033	aldo-keto reductase (NADP) activity	Gains
NVITR	GO:0008447	L-ascorbate oxidase activity	Gains
NVITR	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
NVITR	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
NVITR	GO:0045735	nutrient reservoir activity	Gains
NVITR	GO:0018685	alkane 1-monooxygenase activity	Gains
NVITR	GO:0005212	structural constituent of eye lens	Gains
NVITR	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
NVITR	GO:0042834	peptidoglycan binding	Gains
NVITR	GO:0019955	cytokine binding	Gains
NVITR	GO:0005488	binding	Gains
NVITR	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
NVITR	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
NVITR	GO:0004857	enzyme inhibitor activity	Gains
NVITR	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
NVITR	GO:0042302	structural constituent of cuticle	Gains
NVITR	GO:0016787	hydrolase activity	Gains
NVITR	GO:0061134	peptidase regulator activity	Gains
NVITR	GO:0005272	sodium channel activity	Gains
NVITR	GO:0097159	organic cyclic compound binding	Gains
NVITR	GO:0004386	helicase activity	Gains
NVITR	GO:0004971	AMPA glutamate receptor activity	Gains
NVITR	GO:0004463	leukotriene-A4 hydrolase activity	Gains
NVITR	GO:0004185	serine-type carboxypeptidase activity	Gains
NVITR	GO:1901363	heterocyclic compound binding	Gains
NVITR	GO:0015299	solute:proton antiporter activity	Gains
NVITR	GO:0005509	calcium ion binding	Losses
NVITR	GO:0004683	calmodulin-dependent protein kinase activity	Losses
NVITR	GO:0060072	large conductance calcium-activated potassium channel activity	Losses
NVITR	GO:0017151	DEAD/H-box RNA helicase binding	Losses
NVITR	GO:0097109	neuroligin family protein binding	Losses
NVITR	GO:0015277	kainate selective glutamate receptor activity	Losses
NVITR	GO:0008191	metalloendopeptidase inhibitor activity	Losses
NVITR	GO:0032093	SAM domain binding	Losses
NVITR	GO:0034185	apolipoprotein binding	Losses
NVITR	GO:0004672	protein kinase activity	Losses
NVITR	GO:0008201	heparin binding	Losses
NVITR	GO:0004657	proline dehydrogenase activity	Losses
NVITR	GO:0050220	prostaglandin-E synthase activity	Losses
NVITR	GO:0050824	water binding	Losses
NVITR	GO:0050825	ice binding	Losses
NVITR	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
NVITR	GO:0004496	mevalonate kinase activity	Losses
NVITR	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
NVITR	GO:0005539	glycosaminoglycan binding	Losses
NVITR	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Losses
NVITR	GO:0046873	metal ion transmembrane transporter activity	Losses
NVITR	GO:0005488	binding	Losses
NVITR	GO:0019198	transmembrane receptor protein phosphatase activity	Losses
NVITR	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Losses
NVITR	GO:0097157	pre-mRNA intronic binding	Losses
NVITR	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Losses
NVITR	GO:0005432	calcium:sodium antiporter activity	Losses
NVITR	GO:0004713	protein tyrosine kinase activity	Losses
NVITR	GO:0001158	enhancer sequence-specific DNA binding	Losses
NVITR	GO:0035326	enhancer binding	Losses
NVITR	GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
NVITR	GO:0005509	calcium ion binding	Extinctions
NVITR	GO:0004657	proline dehydrogenase activity	Extinctions
NVITR	GO:0004496	mevalonate kinase activity	Extinctions
NVITR	GO:0097157	pre-mRNA intronic binding	Extinctions
NVITR	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Extinctions
NVITR	GO:0001965	G-protein alpha-subunit binding	Extinctions
NVITR	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Extinctions
NVITR	GO:0036002	pre-mRNA binding	Extinctions
NVITR	GO:0005154	epidermal growth factor receptor binding	Extinctions
LRECL	GO:0003964	RNA-directed DNA polymerase activity	Gains
LRECL	GO:0034061	DNA polymerase activity	Gains
LRECL	GO:0016779	nucleotidyltransferase activity	Gains
LRECL	GO:0140097	catalytic activity, acting on DNA	Gains
LRECL	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
LRECL	GO:0004312	fatty acid synthase activity	Gains
LRECL	GO:0005267	potassium channel activity	Gains
LRECL	GO:0005249	voltage-gated potassium channel activity	Gains
LRECL	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
LRECL	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
LRECL	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
LRECL	GO:0030060	L-malate dehydrogenase activity	Gains
LRECL	GO:0015079	potassium ion transmembrane transporter activity	Gains
LRECL	GO:0097159	organic cyclic compound binding	Gains
LRECL	GO:1901363	heterocyclic compound binding	Gains
LRECL	GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
LRECL	GO:0004692	cGMP-dependent protein kinase activity	Gains
LRECL	GO:0016615	malate dehydrogenase activity	Gains
LRECL	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
LRECL	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Gains
LRECL	GO:0015269	calcium-activated potassium channel activity	Gains
LRECL	GO:0010340	carboxyl-O-methyltransferase activity	Gains
LRECL	GO:0008307	structural constituent of muscle	Gains
LRECL	GO:0005227	calcium activated cation channel activity	Gains
LRECL	GO:0019199	transmembrane receptor protein kinase activity	Gains
LRECL	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
LRECL	GO:0052689	carboxylic ester hydrolase activity	Gains
LRECL	GO:0022843	voltage-gated cation channel activity	Gains
LRECL	GO:0005506	iron ion binding	Gains
LRECL	GO:0070330	aromatase activity	Gains
LRECL	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
LRECL	GO:0003676	nucleic acid binding	Gains
LRECL	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	Gains
LRECL	GO:0004632	phosphopantothenate--cysteine ligase activity	Gains
LRECL	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Gains
LRECL	GO:0005222	intracellular cAMP activated cation channel activity	Gains
LRECL	GO:0005223	intracellular cGMP activated cation channel activity	Gains
LRECL	GO:0005261	cation channel activity	Gains
LRECL	GO:0004691	cAMP-dependent protein kinase activity	Gains
LRECL	GO:0030551	cyclic nucleotide binding	Gains
LRECL	GO:0022839	ion gated channel activity	Gains
LRECL	GO:0008408	3'-5' exonuclease activity	Gains
LRECL	GO:0004812	aminoacyl-tRNA ligase activity	Gains
LRECL	GO:0000175	3'-5'-exoribonuclease activity	Gains
LRECL	GO:0046873	metal ion transmembrane transporter activity	Gains
LRECL	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
LRECL	GO:0016854	racemase and epimerase activity	Gains
LRECL	GO:0042302	structural constituent of cuticle	Gains
LRECL	GO:0008603	cAMP-dependent protein kinase regulator activity	Gains
LRECL	GO:0016411	acylglycerol O-acyltransferase activity	Gains
LRECL	GO:0004075	biotin carboxylase activity	Gains
LRECL	GO:0008171	O-methyltransferase activity	Gains
LRECL	GO:0003824	catalytic activity	Losses
LRECL	GO:0043021	ribonucleoprotein complex binding	Losses
LRECL	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Losses
LRECL	GO:0005179	hormone activity	Losses
LRECL	GO:0005184	neuropeptide hormone activity	Losses
LRECL	GO:0016741	transferase activity, transferring one-carbon groups	Losses
LRECL	GO:0008026	ATP-dependent helicase activity	Losses
LRECL	GO:0070035	purine NTP-dependent helicase activity	Losses
LRECL	GO:0005484	SNAP receptor activity	Losses
LRECL	GO:0008168	methyltransferase activity	Losses
LRECL	GO:0016409	palmitoyltransferase activity	Losses
LRECL	GO:0008276	protein methyltransferase activity	Losses
LRECL	GO:0048037	cofactor binding	Losses
LRECL	GO:0004550	nucleoside diphosphate kinase activity	Losses
LRECL	GO:0016740	transferase activity	Losses
LRECL	GO:0042054	histone methyltransferase activity	Losses
LRECL	GO:0008374	O-acyltransferase activity	Losses
LRECL	GO:0036094	small molecule binding	Losses
LRECL	GO:0008170	N-methyltransferase activity	Losses
LRECL	GO:0000166	nucleotide binding	Losses
LRECL	GO:1901265	nucleoside phosphate binding	Losses
LRECL	GO:0009982	pseudouridine synthase activity	Losses
LRECL	GO:0050662	coenzyme binding	Losses
LRECL	GO:0043168	anion binding	Losses
LRECL	GO:0048018	receptor ligand activity	Losses
LRECL	GO:0016877	ligase activity, forming carbon-sulfur bonds	Losses
LRECL	GO:0016859	cis-trans isomerase activity	Losses
LRECL	GO:0019200	carbohydrate kinase activity	Losses
LRECL	GO:0019107	myristoyltransferase activity	Losses
LRECL	GO:0016909	SAP kinase activity	Losses
LRECL	GO:0035613	RNA stem-loop binding	Losses
LRECL	GO:0009008	DNA-methyltransferase activity	Losses
LRECL	GO:0005047	signal recognition particle binding	Losses
LRECL	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
LRECL	GO:0004033	aldo-keto reductase (NADP) activity	Losses
LRECL	GO:0008410	CoA-transferase activity	Losses
LRECL	GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
LRECL	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Losses
LRECL	GO:0071855	neuropeptide receptor binding	Losses
LRECL	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Losses
LRECL	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Losses
LRECL	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Losses
LRECL	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Losses
LRECL	GO:0004803	transposase activity	Losses
LRECL	GO:0000062	fatty-acyl-CoA binding	Losses
LRECL	GO:1901567	fatty acid derivative binding	Losses
LRECL	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Losses
LRECL	GO:0004386	helicase activity	Losses
LRECL	GO:0016840	carbon-nitrogen lyase activity	Losses
LRECL	GO:0017169	CDP-alcohol phosphatidyltransferase activity	Losses
LRECL	GO:0004707	MAP kinase activity	Losses
LRECL	GO:0043139	5'-3' DNA helicase activity	Losses
LRECL	GO:0030170	pyridoxal phosphate binding	Losses
LRECL	GO:0070279	vitamin B6 binding	Losses
LRECL	GO:0035091	phosphatidylinositol binding	Losses
LRECL	GO:0016817	hydrolase activity, acting on acid anhydrides	Losses
LRECL	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Losses
LRECL	GO:0019205	nucleobase-containing compound kinase activity	Losses
LRECL	GO:0019843	rRNA binding	Losses
LRECL	GO:0008235	metalloexopeptidase activity	Losses
LRECL	GO:0030545	receptor regulator activity	Losses
LRECL	GO:0016278	lysine N-methyltransferase activity	Losses
LRECL	GO:0016279	protein-lysine N-methyltransferase activity	Losses
LRECL	GO:0018024	histone-lysine N-methyltransferase activity	Losses
LRECL	GO:0043167	ion binding	Losses
LRECL	GO:0030554	adenyl nucleotide binding	Losses
LRECL	GO:0008641	ubiquitin-like modifier activating enzyme activity	Losses
LRECL	GO:0043021	ribonucleoprotein complex binding	Extinctions
LRECL	GO:0003824	catalytic activity	Extinctions
LRECL	GO:0004550	nucleoside diphosphate kinase activity	Extinctions
LRECL	GO:0008026	ATP-dependent helicase activity	Extinctions
LRECL	GO:0070035	purine NTP-dependent helicase activity	Extinctions
LRECL	GO:0005179	hormone activity	Extinctions
LRECL	GO:0016409	palmitoyltransferase activity	Extinctions
LRECL	GO:0005184	neuropeptide hormone activity	Extinctions
LRECL	GO:0016877	ligase activity, forming carbon-sulfur bonds	Extinctions
LRECL	GO:0008641	ubiquitin-like modifier activating enzyme activity	Extinctions
LRECL	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Extinctions
LRECL	GO:0019107	myristoyltransferase activity	Extinctions
LRECL	GO:0009008	DNA-methyltransferase activity	Extinctions
LRECL	GO:0005047	signal recognition particle binding	Extinctions
LRECL	GO:0008410	CoA-transferase activity	Extinctions
LRECL	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Extinctions
LRECL	GO:0071855	neuropeptide receptor binding	Extinctions
LRECL	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Extinctions
LRECL	GO:0043139	5'-3' DNA helicase activity	Extinctions
LRECL	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
LRECL	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
LRECL	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
LRECL	GO:0009982	pseudouridine synthase activity	Extinctions
LRECL	GO:0050662	coenzyme binding	Extinctions
LRECL	GO:0016741	transferase activity, transferring one-carbon groups	Extinctions
LRECL	GO:0005048	signal sequence binding	Extinctions
LRECL	GO:0019843	rRNA binding	Extinctions
LRECL	GO:0048037	cofactor binding	Extinctions
LRECL	GO:0008168	methyltransferase activity	Extinctions
LRECL	GO:0016874	ligase activity	Extinctions
LRECL	GO:0019200	carbohydrate kinase activity	Extinctions
LRECL	GO:0008276	protein methyltransferase activity	Extinctions
LRECL	GO:0070567	cytidylyltransferase activity	Extinctions
LRECL	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
LRECL	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Extinctions
LRECL	GO:0003954	NADH dehydrogenase activity	Extinctions
LRECL	GO:0042887	amide transmembrane transporter activity	Extinctions
LRECL	GO:1904680	peptide transmembrane transporter activity	Extinctions
LRECL	GO:0008170	N-methyltransferase activity	Extinctions
LRECL	GO:0140101	catalytic activity, acting on a tRNA	Extinctions
LRECL	GO:0140098	catalytic activity, acting on RNA	Extinctions
BMORI	GO:0003964	RNA-directed DNA polymerase activity	Gains
BMORI	GO:0034061	DNA polymerase activity	Gains
BMORI	GO:0140097	catalytic activity, acting on DNA	Gains
BMORI	GO:0003774	motor activity	Gains
BMORI	GO:0003777	microtubule motor activity	Gains
BMORI	GO:0004519	endonuclease activity	Gains
BMORI	GO:0016779	nucleotidyltransferase activity	Gains
BMORI	GO:0070001	aspartic-type peptidase activity	Gains
BMORI	GO:0004190	aspartic-type endopeptidase activity	Gains
BMORI	GO:0035326	enhancer binding	Gains
BMORI	GO:0001158	enhancer sequence-specific DNA binding	Gains
BMORI	GO:0000976	transcription regulatory region sequence-specific DNA binding	Gains
BMORI	GO:0004518	nuclease activity	Gains
BMORI	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
BMORI	GO:0052742	phosphatidylinositol kinase activity	Gains
BMORI	GO:1990837	sequence-specific double-stranded DNA binding	Gains
BMORI	GO:0004000	adenosine deaminase activity	Gains
BMORI	GO:0001012	RNA polymerase II regulatory region DNA binding	Gains
BMORI	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
BMORI	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	Gains
BMORI	GO:0004430	1-phosphatidylinositol 4-kinase activity	Gains
BMORI	GO:0004144	diacylglycerol O-acyltransferase activity	Gains
BMORI	GO:0004771	sterol esterase activity	Gains
BMORI	GO:0004827	proline-tRNA ligase activity	Gains
BMORI	GO:0004815	aspartate-tRNA ligase activity	Gains
BMORI	GO:0019992	diacylglycerol binding	Gains
BMORI	GO:0020037	heme binding	Gains
BMORI	GO:0003727	single-stranded RNA binding	Gains
BMORI	GO:0043565	sequence-specific DNA binding	Gains
BMORI	GO:0046906	tetrapyrrole binding	Gains
BMORI	GO:0004725	protein tyrosine phosphatase activity	Gains
BMORI	GO:0003964	RNA-directed DNA polymerase activity	Losses
BMORI	GO:0038023	signaling receptor activity	Losses
BMORI	GO:0004984	olfactory receptor activity	Losses
BMORI	GO:0004888	transmembrane signaling receptor activity	Losses
BMORI	GO:0099600	transmembrane receptor activity	Losses
BMORI	GO:0004872	receptor activity	Losses
BMORI	GO:0060089	molecular transducer activity	Losses
BMORI	GO:0034061	DNA polymerase activity	Losses
BMORI	GO:0005549	odorant binding	Losses
BMORI	GO:0004930	G-protein coupled receptor activity	Losses
BMORI	GO:0004871	signal transducer activity	Losses
BMORI	GO:0016779	nucleotidyltransferase activity	Losses
BMORI	GO:0004519	endonuclease activity	Losses
BMORI	GO:0140097	catalytic activity, acting on DNA	Losses
BMORI	GO:0004518	nuclease activity	Losses
BMORI	GO:0008527	taste receptor activity	Losses
BMORI	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
BMORI	GO:0008329	signaling pattern recognition receptor activity	Losses
BMORI	GO:0038187	pattern recognition receptor activity	Losses
BMORI	GO:0015232	heme transporter activity	Losses
BMORI	GO:0004857	enzyme inhibitor activity	Losses
BMORI	GO:0004549	tRNA-specific ribonuclease activity	Losses
BMORI	GO:0019209	kinase activator activity	Losses
BMORI	GO:0030295	protein kinase activator activity	Losses
BMORI	GO:0030545	receptor regulator activity	Losses
BMORI	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Losses
BMORI	GO:0043539	protein serine/threonine kinase activator activity	Losses
BMORI	GO:0018685	alkane 1-monooxygenase activity	Losses
BMORI	GO:0033041	sweet taste receptor activity	Losses
BMORI	GO:0004521	endoribonuclease activity	Losses
BMORI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
BMORI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
BMORI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
BMORI	GO:0004526	ribonuclease P activity	Losses
BMORI	GO:0005328	neurotransmitter:sodium symporter activity	Losses
BMORI	GO:0098772	molecular function regulator	Losses
BMORI	GO:0051184	cofactor transporter activity	Losses
BMORI	GO:0008233	peptidase activity	Losses
BMORI	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
BMORI	GO:0046592	polyamine oxidase activity	Losses
BMORI	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
BMORI	GO:0004948	calcitonin receptor activity	Losses
BMORI	GO:0005416	cation:amino acid symporter activity	Losses
BMORI	GO:0097642	calcitonin family receptor activity	Losses
BMORI	GO:0015439	heme-transporting ATPase activity	Losses
BMORI	GO:0005283	sodium:amino acid symporter activity	Losses
BMORI	GO:0008036	diuretic hormone receptor activity	Losses
BMORI	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
BMORI	GO:0008528	G-protein coupled peptide receptor activity	Losses
BMORI	GO:0015370	solute:sodium symporter activity	Losses
BMORI	GO:0015294	solute:cation symporter activity	Losses
BMORI	GO:0004602	glutathione peroxidase activity	Losses
BMORI	GO:0015144	carbohydrate transmembrane transporter activity	Losses
BMORI	GO:0070330	aromatase activity	Losses
BMORI	GO:0051119	sugar transmembrane transporter activity	Losses
BMORI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
BMORI	GO:0005326	neurotransmitter transporter activity	Losses
BMORI	GO:0030234	enzyme regulator activity	Losses
BMORI	GO:0001653	peptide receptor activity	Losses
BMORI	GO:0009055	electron transfer activity	Losses
BMORI	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
BMORI	GO:0004364	glutathione transferase activity	Losses
BMORI	GO:0140102	catalytic activity, acting on a rRNA	Losses
BMORI	GO:0008649	rRNA methyltransferase activity	Losses
BMORI	GO:0004540	ribonuclease activity	Losses
BMORI	GO:0017160	Ral GTPase binding	Losses
BMORI	GO:0051032	nucleic acid transmembrane transporter activity	Losses
BMORI	GO:0051033	RNA transmembrane transporter activity	Losses
BMORI	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
BMORI	GO:0048018	receptor ligand activity	Losses
BMORI	GO:0140098	catalytic activity, acting on RNA	Losses
BMORI	GO:0004984	olfactory receptor activity	Extinctions
BMORI	GO:0005549	odorant binding	Extinctions
BMORI	GO:0004888	transmembrane signaling receptor activity	Extinctions
BMORI	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
BMORI	GO:0004519	endonuclease activity	Extinctions
BMORI	GO:0099600	transmembrane receptor activity	Extinctions
BMORI	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
BMORI	GO:0004930	G-protein coupled receptor activity	Extinctions
BMORI	GO:0034061	DNA polymerase activity	Extinctions
BMORI	GO:0038023	signaling receptor activity	Extinctions
BMORI	GO:0004518	nuclease activity	Extinctions
BMORI	GO:0004857	enzyme inhibitor activity	Extinctions
BMORI	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
BMORI	GO:0004526	ribonuclease P activity	Extinctions
BMORI	GO:0140097	catalytic activity, acting on DNA	Extinctions
BMORI	GO:0016779	nucleotidyltransferase activity	Extinctions
BMORI	GO:0004872	receptor activity	Extinctions
BMORI	GO:0030545	receptor regulator activity	Extinctions
BMORI	GO:0098772	molecular function regulator	Extinctions
BMORI	GO:0060089	molecular transducer activity	Extinctions
BMORI	GO:0140101	catalytic activity, acting on a tRNA	Extinctions
BMORI	GO:0051032	nucleic acid transmembrane transporter activity	Extinctions
BMORI	GO:0051033	RNA transmembrane transporter activity	Extinctions
BMORI	GO:0004871	signal transducer activity	Extinctions
BMORI	GO:0019209	kinase activator activity	Extinctions
BMORI	GO:0030295	protein kinase activator activity	Extinctions
BMORI	GO:0030414	peptidase inhibitor activity	Extinctions
BMORI	GO:0003730	mRNA 3'-UTR binding	Extinctions
BMORI	GO:0008158	hedgehog receptor activity	Extinctions
BMORI	GO:0008527	taste receptor activity	Extinctions
BMORI	GO:0031208	POZ domain binding	Extinctions
CLECT	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
CLECT	GO:0015294	solute:cation symporter activity	Gains
CLECT	GO:0015293	symporter activity	Gains
CLECT	GO:0015291	secondary active transmembrane transporter activity	Gains
CLECT	GO:0140097	catalytic activity, acting on DNA	Gains
CLECT	GO:0015295	solute:proton symporter activity	Gains
CLECT	GO:0005351	sugar:proton symporter activity	Gains
CLECT	GO:0005402	cation:sugar symporter activity	Gains
CLECT	GO:0000156	phosphorelay response regulator activity	Gains
CLECT	GO:0015144	carbohydrate transmembrane transporter activity	Gains
CLECT	GO:0003964	RNA-directed DNA polymerase activity	Gains
CLECT	GO:0016149	translation release factor activity, codon specific	Gains
CLECT	GO:0051119	sugar transmembrane transporter activity	Gains
CLECT	GO:0005343	organic acid:sodium symporter activity	Gains
CLECT	GO:1901363	heterocyclic compound binding	Gains
CLECT	GO:0097159	organic cyclic compound binding	Gains
CLECT	GO:0034061	DNA polymerase activity	Gains
CLECT	GO:0022804	active transmembrane transporter activity	Gains
CLECT	GO:0048037	cofactor binding	Gains
CLECT	GO:0017153	sodium:dicarboxylate symporter activity	Gains
CLECT	GO:0030170	pyridoxal phosphate binding	Gains
CLECT	GO:0070279	vitamin B6 binding	Gains
CLECT	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
CLECT	GO:0016491	oxidoreductase activity	Gains
CLECT	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
CLECT	GO:0019842	vitamin binding	Gains
CLECT	GO:0015370	solute:sodium symporter activity	Gains
CLECT	GO:0019238	cyclohydrolase activity	Gains
CLECT	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
CLECT	GO:0043115	precorrin-2 dehydrogenase activity	Gains
CLECT	GO:0016151	nickel cation binding	Gains
CLECT	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
CLECT	GO:0070001	aspartic-type peptidase activity	Gains
CLECT	GO:0004190	aspartic-type endopeptidase activity	Gains
CLECT	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
CLECT	GO:0005342	organic acid transmembrane transporter activity	Gains
CLECT	GO:0008514	organic anion transmembrane transporter activity	Gains
CLECT	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
CLECT	GO:0015035	protein disulfide oxidoreductase activity	Gains
CLECT	GO:0016829	lyase activity	Gains
CLECT	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
CLECT	GO:0015075	ion transmembrane transporter activity	Gains
CLECT	GO:0008483	transaminase activity	Gains
CLECT	GO:0016769	transferase activity, transferring nitrogenous groups	Gains
CLECT	GO:0003824	catalytic activity	Gains
CLECT	GO:0015081	sodium ion transmembrane transporter activity	Gains
CLECT	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
CLECT	GO:0016500	protein-hormone receptor activity	Gains
CLECT	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
CLECT	GO:0008324	cation transmembrane transporter activity	Gains
CLECT	GO:0015296	anion:cation symporter activity	Gains
CLECT	GO:0004736	pyruvate carboxylase activity	Gains
CLECT	GO:0008658	penicillin binding	Gains
CLECT	GO:0004070	aspartate carbamoyltransferase activity	Gains
CLECT	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
CLECT	GO:0008169	C-methyltransferase activity	Gains
CLECT	GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
CLECT	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
CLECT	GO:0043682	copper-transporting ATPase activity	Gains
CLECT	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
CLECT	GO:0015036	disulfide oxidoreductase activity	Gains
CLECT	GO:0016763	transferase activity, transferring pentosyl groups	Gains
CLECT	GO:0008509	anion transmembrane transporter activity	Gains
CLECT	GO:0016462	pyrophosphatase activity	Gains
CLECT	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
CLECT	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
CLECT	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
CLECT	GO:0016779	nucleotidyltransferase activity	Gains
CLECT	GO:0003676	nucleic acid binding	Gains
CLECT	GO:0008079	translation termination factor activity	Gains
CLECT	GO:0003747	translation release factor activity	Gains
CLECT	GO:0016615	malate dehydrogenase activity	Gains
CLECT	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
CLECT	GO:0016209	antioxidant activity	Gains
CLECT	GO:0009055	electron transfer activity	Gains
CLECT	GO:0042302	structural constituent of cuticle	Losses
CLECT	GO:0005179	hormone activity	Losses
CLECT	GO:0004016	adenylate cyclase activity	Losses
CLECT	GO:0019136	deoxynucleoside kinase activity	Losses
CLECT	GO:0004797	thymidine kinase activity	Losses
CLECT	GO:0015183	L-aspartate transmembrane transporter activity	Losses
CLECT	GO:0015501	glutamate:sodium symporter activity	Losses
CLECT	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
CLECT	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
CLECT	GO:0005184	neuropeptide hormone activity	Losses
CLECT	GO:0003729	mRNA binding	Losses
CLECT	GO:0048037	cofactor binding	Losses
CLECT	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
CLECT	GO:0035250	UDP-galactosyltransferase activity	Losses
CLECT	GO:0004364	glutathione transferase activity	Losses
CLECT	GO:0048018	receptor ligand activity	Losses
CLECT	GO:0005201	extracellular matrix structural constituent	Losses
CLECT	GO:0004629	phospholipase C activity	Losses
CLECT	GO:0004435	phosphatidylinositol phospholipase C activity	Losses
CLECT	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Losses
CLECT	GO:0015278	calcium-release channel activity	Losses
CLECT	GO:0005416	cation:amino acid symporter activity	Losses
CLECT	GO:0099604	ligand-gated calcium channel activity	Losses
CLECT	GO:0005283	sodium:amino acid symporter activity	Losses
CLECT	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
CLECT	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
CLECT	GO:0030545	receptor regulator activity	Losses
CLECT	GO:0008378	galactosyltransferase activity	Losses
CLECT	GO:0016740	transferase activity	Losses
CLECT	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
CLECT	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
CLECT	GO:0099094	ligand-gated cation channel activity	Losses
CLECT	GO:0009881	photoreceptor activity	Losses
CLECT	GO:0005214	structural constituent of chitin-based cuticle	Losses
CLECT	GO:0008889	glycerophosphodiester phosphodiesterase activity	Losses
CLECT	GO:0000828	inositol hexakisphosphate kinase activity	Losses
CLECT	GO:0000832	inositol hexakisphosphate 5-kinase activity	Losses
CLECT	GO:0052723	inositol hexakisphosphate 1-kinase activity	Losses
CLECT	GO:0052724	inositol hexakisphosphate 3-kinase activity	Losses
CLECT	GO:0015556	C4-dicarboxylate transmembrane transporter activity	Losses
CLECT	GO:0047915	ganglioside galactosyltransferase activity	Losses
CLECT	GO:0098772	molecular function regulator	Losses
CLECT	GO:0005509	calcium ion binding	Losses
CLECT	GO:0004180	carboxypeptidase activity	Losses
CLECT	GO:0050662	coenzyme binding	Losses
CLECT	GO:0015172	acidic amino acid transmembrane transporter activity	Losses
CLECT	GO:0005313	L-glutamate transmembrane transporter activity	Losses
CLECT	GO:0072341	modified amino acid binding	Losses
CLECT	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
CLECT	GO:0017048	Rho GTPase binding	Losses
CLECT	GO:0015179	L-amino acid transmembrane transporter activity	Losses
CLECT	GO:0005217	intracellular ligand-gated ion channel activity	Losses
CLECT	GO:0005184	neuropeptide hormone activity	Extinctions
CLECT	GO:0005179	hormone activity	Extinctions
CLECT	GO:0048018	receptor ligand activity	Extinctions
CLECT	GO:0030545	receptor regulator activity	Extinctions
CLECT	GO:0140104	molecular carrier activity	Extinctions
CLECT	GO:0051192	prosthetic group binding	Extinctions
CLECT	GO:0031177	phosphopantetheine binding	Extinctions
CLECT	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
CLECT	GO:0008613	diuretic hormone activity	Extinctions
CLECT	GO:0019784	NEDD8-specific protease activity	Extinctions
CLECT	GO:0001888	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Extinctions
CLECT	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	Extinctions
CLECT	GO:0015562	efflux transmembrane transporter activity	Extinctions
CLECT	GO:0000036	acyl carrier activity	Extinctions
CLECT	GO:0019706	protein-cysteine S-palmitoyltransferase activity	Extinctions
CLECT	GO:0019707	protein-cysteine S-acyltransferase activity	Extinctions
ZNEVA	GO:0005549	odorant binding	Gains
ZNEVA	GO:0099600	transmembrane receptor activity	Gains
ZNEVA	GO:0004888	transmembrane signaling receptor activity	Gains
ZNEVA	GO:0004984	olfactory receptor activity	Gains
ZNEVA	GO:0038023	signaling receptor activity	Gains
ZNEVA	GO:0004872	receptor activity	Gains
ZNEVA	GO:0060089	molecular transducer activity	Gains
ZNEVA	GO:0004871	signal transducer activity	Gains
ZNEVA	GO:0008527	taste receptor activity	Gains
ZNEVA	GO:0004930	G-protein coupled receptor activity	Gains
ZNEVA	GO:0022824	transmitter-gated ion channel activity	Gains
ZNEVA	GO:0022835	transmitter-gated channel activity	Gains
ZNEVA	GO:0004970	ionotropic glutamate receptor activity	Gains
ZNEVA	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
ZNEVA	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
ZNEVA	GO:0008066	glutamate receptor activity	Gains
ZNEVA	GO:0015276	ligand-gated ion channel activity	Gains
ZNEVA	GO:0022834	ligand-gated channel activity	Gains
ZNEVA	GO:0030594	neurotransmitter receptor activity	Gains
ZNEVA	GO:0003964	RNA-directed DNA polymerase activity	Gains
ZNEVA	GO:0005216	ion channel activity	Gains
ZNEVA	GO:0022838	substrate-specific channel activity	Gains
ZNEVA	GO:0005230	extracellular ligand-gated ion channel activity	Gains
ZNEVA	GO:0015267	channel activity	Gains
ZNEVA	GO:0022803	passive transmembrane transporter activity	Gains
ZNEVA	GO:0022836	gated channel activity	Gains
ZNEVA	GO:0034061	DNA polymerase activity	Gains
ZNEVA	GO:0015075	ion transmembrane transporter activity	Gains
ZNEVA	GO:0022891	substrate-specific transmembrane transporter activity	Gains
ZNEVA	GO:0022857	transmembrane transporter activity	Gains
ZNEVA	GO:0022892	substrate-specific transporter activity	Gains
ZNEVA	GO:0140097	catalytic activity, acting on DNA	Gains
ZNEVA	GO:0005550	pheromone binding	Gains
ZNEVA	GO:0005272	sodium channel activity	Gains
ZNEVA	GO:0016779	nucleotidyltransferase activity	Gains
ZNEVA	GO:0036081	extracellular ammonia-gated ion channel activity	Gains
ZNEVA	GO:0005215	transporter activity	Gains
ZNEVA	GO:0005261	cation channel activity	Gains
ZNEVA	GO:0004190	aspartic-type endopeptidase activity	Gains
ZNEVA	GO:0070001	aspartic-type peptidase activity	Gains
ZNEVA	GO:0033041	sweet taste receptor activity	Gains
ZNEVA	GO:0046873	metal ion transmembrane transporter activity	Gains
ZNEVA	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
ZNEVA	GO:0048027	mRNA 5'-UTR binding	Gains
ZNEVA	GO:0003676	nucleic acid binding	Gains
ZNEVA	GO:0008061	chitin binding	Gains
ZNEVA	GO:0043141	ATP-dependent 5'-3' DNA helicase activity	Gains
ZNEVA	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
ZNEVA	GO:0005158	insulin receptor binding	Gains
ZNEVA	GO:0004768	stearoyl-CoA 9-desaturase activity	Gains
ZNEVA	GO:0016215	acyl-CoA desaturase activity	Gains
ZNEVA	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
ZNEVA	GO:0022890	inorganic cation transmembrane transporter activity	Gains
ZNEVA	GO:0003964	RNA-directed DNA polymerase activity	Losses
ZNEVA	GO:0140097	catalytic activity, acting on DNA	Losses
ZNEVA	GO:0034061	DNA polymerase activity	Losses
ZNEVA	GO:0003677	DNA binding	Losses
ZNEVA	GO:0016779	nucleotidyltransferase activity	Losses
ZNEVA	GO:0004190	aspartic-type endopeptidase activity	Losses
ZNEVA	GO:0070001	aspartic-type peptidase activity	Losses
ZNEVA	GO:0046872	metal ion binding	Losses
ZNEVA	GO:0043169	cation binding	Losses
ZNEVA	GO:0003700	DNA binding transcription factor activity	Losses
ZNEVA	GO:0003676	nucleic acid binding	Losses
ZNEVA	GO:0009881	photoreceptor activity	Losses
ZNEVA	GO:0005214	structural constituent of chitin-based cuticle	Losses
ZNEVA	GO:0140110	transcription regulator activity	Losses
ZNEVA	GO:0008201	heparin binding	Losses
ZNEVA	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
ZNEVA	GO:0003690	double-stranded DNA binding	Losses
ZNEVA	GO:0046914	transition metal ion binding	Losses
ZNEVA	GO:0008270	zinc ion binding	Losses
ZNEVA	GO:0004803	transposase activity	Losses
ZNEVA	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
ZNEVA	GO:0003913	DNA photolyase activity	Losses
ZNEVA	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
ZNEVA	GO:0008020	G-protein coupled photoreceptor activity	Losses
ZNEVA	GO:0050591	quinine 3-monooxygenase activity	Losses
ZNEVA	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
ZNEVA	GO:0004470	malic enzyme activity	Losses
ZNEVA	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Losses
ZNEVA	GO:0043565	sequence-specific DNA binding	Losses
ZNEVA	GO:1901363	heterocyclic compound binding	Losses
ZNEVA	GO:0005539	glycosaminoglycan binding	Losses
ZNEVA	GO:0097159	organic cyclic compound binding	Losses
ZNEVA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
ZNEVA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
ZNEVA	GO:0005488	binding	Losses
ZNEVA	GO:0003707	steroid hormone receptor activity	Losses
ZNEVA	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Losses
ZNEVA	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
ZNEVA	GO:0003990	acetylcholinesterase activity	Losses
ZNEVA	GO:0019992	diacylglycerol binding	Losses
ZNEVA	GO:0008061	chitin binding	Losses
ZNEVA	GO:0044212	transcription regulatory region DNA binding	Losses
ZNEVA	GO:1901681	sulfur compound binding	Losses
ZNEVA	GO:0000975	regulatory region DNA binding	Losses
ZNEVA	GO:0001067	regulatory region nucleic acid binding	Losses
ZNEVA	GO:0004518	nuclease activity	Losses
ZNEVA	GO:0060089	molecular transducer activity	Losses
ZNEVA	GO:0008301	DNA binding, bending	Losses
ZNEVA	GO:0004104	cholinesterase activity	Losses
ZNEVA	GO:0004364	glutathione transferase activity	Losses
ZNEVA	GO:0004872	receptor activity	Losses
ZNEVA	GO:0004879	nuclear receptor activity	Losses
ZNEVA	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Losses
ZNEVA	GO:0097747	RNA polymerase activity	Losses
ZNEVA	GO:0034062	5'-3' RNA polymerase activity	Losses
ZNEVA	GO:0019238	cyclohydrolase activity	Losses
ZNEVA	GO:0016406	carnitine O-acyltransferase activity	Losses
ZNEVA	GO:0009008	DNA-methyltransferase activity	Losses
ZNEVA	GO:0015368	calcium:cation antiporter activity	Losses
ZNEVA	GO:0043167	ion binding	Losses
ZNEVA	GO:0004175	endopeptidase activity	Losses
ZNEVA	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
ZNEVA	GO:0099094	ligand-gated cation channel activity	Losses
ZNEVA	GO:0030247	polysaccharide binding	Losses
ZNEVA	GO:0001871	pattern binding	Losses
ZNEVA	GO:0099516	ion antiporter activity	Losses
ZNEVA	GO:0016769	transferase activity, transferring nitrogenous groups	Losses
ZNEVA	GO:0008483	transaminase activity	Losses
ZNEVA	GO:0016615	malate dehydrogenase activity	Losses
ZNEVA	GO:0008307	structural constituent of muscle	Losses
ZNEVA	GO:0000976	transcription regulatory region sequence-specific DNA binding	Losses
ZNEVA	GO:0015297	antiporter activity	Losses
ZNEVA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
ZNEVA	GO:0005509	calcium ion binding	Losses
ZNEVA	GO:0003677	DNA binding	Extinctions
ZNEVA	GO:0003676	nucleic acid binding	Extinctions
ZNEVA	GO:0140097	catalytic activity, acting on DNA	Extinctions
ZNEVA	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
ZNEVA	GO:0034061	DNA polymerase activity	Extinctions
ZNEVA	GO:0016779	nucleotidyltransferase activity	Extinctions
ZNEVA	GO:0003690	double-stranded DNA binding	Extinctions
ZNEVA	GO:0003700	DNA binding transcription factor activity	Extinctions
ZNEVA	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Extinctions
ZNEVA	GO:0004803	transposase activity	Extinctions
ZNEVA	GO:0140110	transcription regulator activity	Extinctions
ZNEVA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
ZNEVA	GO:0070001	aspartic-type peptidase activity	Extinctions
ZNEVA	GO:0046872	metal ion binding	Extinctions
ZNEVA	GO:0016406	carnitine O-acyltransferase activity	Extinctions
ZNEVA	GO:0043169	cation binding	Extinctions
ZNEVA	GO:0008201	heparin binding	Extinctions
ZNEVA	GO:0044212	transcription regulatory region DNA binding	Extinctions
ZNEVA	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
ZNEVA	GO:0000975	regulatory region DNA binding	Extinctions
ZNEVA	GO:0001067	regulatory region nucleic acid binding	Extinctions
ZNEVA	GO:0043565	sequence-specific DNA binding	Extinctions
ZNEVA	GO:0008061	chitin binding	Extinctions
ZNEVA	GO:0004518	nuclease activity	Extinctions
ZNEVA	GO:1901363	heterocyclic compound binding	Extinctions
ZNEVA	GO:0046914	transition metal ion binding	Extinctions
ZNEVA	GO:0097159	organic cyclic compound binding	Extinctions
ZNEVA	GO:0097747	RNA polymerase activity	Extinctions
ZNEVA	GO:0034062	5'-3' RNA polymerase activity	Extinctions
ZNEVA	GO:0008301	DNA binding, bending	Extinctions
ZNEVA	GO:0000976	transcription regulatory region sequence-specific DNA binding	Extinctions
ZNEVA	GO:0008270	zinc ion binding	Extinctions
ZNEVA	GO:0005214	structural constituent of chitin-based cuticle	Extinctions
ZNEVA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Extinctions
ZNEVA	GO:0033608	formyl-CoA transferase activity	Extinctions
ZNEVA	GO:0042586	peptide deformylase activity	Extinctions
ZNEVA	GO:0043295	glutathione binding	Extinctions
ZNEVA	GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
ZNEVA	GO:0015280	ligand-gated sodium channel activity	Extinctions
ZNEVA	GO:0051908	double-stranded DNA 5'-3' exodeoxyribonuclease activity	Extinctions
ZNEVA	GO:0005104	fibroblast growth factor receptor binding	Extinctions
ZNEVA	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
ZNEVA	GO:0008816	citryl-CoA lyase activity	Extinctions
ZNEVA	GO:0016414	O-octanoyltransferase activity	Extinctions
ZNEVA	GO:0047536	2-aminoadipate transaminase activity	Extinctions
ZNEVA	GO:0004846	urate oxidase activity	Extinctions
ZNEVA	GO:0047617	acyl-CoA hydrolase activity	Extinctions
ZNEVA	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	Extinctions
ZNEVA	GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
ZNEVA	GO:0004666	prostaglandin-endoperoxide synthase activity	Extinctions
ZNEVA	GO:0044736	acid-sensing ion channel activity	Extinctions
ZNEVA	GO:0004092	carnitine O-acetyltransferase activity	Extinctions
ZNEVA	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
ZNEVA	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
ZNEVA	GO:0008458	carnitine O-octanoyltransferase activity	Extinctions
ZNEVA	GO:0046875	ephrin receptor binding	Extinctions
ZNEVA	GO:0008473	ornithine cyclodeaminase activity	Extinctions
ZNEVA	GO:0008477	purine nucleosidase activity	Extinctions
ZNEVA	GO:0008196	vitellogenin receptor activity	Extinctions
ZNEVA	GO:0003720	telomerase activity	Extinctions
ZNEVA	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
ZNEVA	GO:1900750	oligopeptide binding	Extinctions
ZNEVA	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
ZNEVA	GO:0016769	transferase activity, transferring nitrogenous groups	Extinctions
ZNEVA	GO:0008483	transaminase activity	Extinctions
ZNEVA	GO:1901681	sulfur compound binding	Extinctions
ZNEVA	GO:0005509	calcium ion binding	Extinctions
74	GO:0099600	transmembrane receptor activity	Gains
74	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
74	GO:0004871	signal transducer activity	Gains
74	GO:0038023	signaling receptor activity	Gains
74	GO:0004872	receptor activity	Gains
74	GO:0004888	transmembrane signaling receptor activity	Gains
74	GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
74	GO:0060089	molecular transducer activity	Gains
74	GO:0019840	isoprenoid binding	Gains
74	GO:0042834	peptidoglycan binding	Gains
74	GO:0005102	receptor binding	Gains
74	GO:0004745	retinol dehydrogenase activity	Gains
74	GO:0005500	juvenile hormone binding	Gains
74	GO:0004565	beta-galactosidase activity	Gains
74	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	Gains
74	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Gains
74	GO:0005212	structural constituent of eye lens	Gains
74	GO:0004930	G-protein coupled receptor activity	Gains
74	GO:0061783	peptidoglycan muralytic activity	Gains
74	GO:0042562	hormone binding	Gains
74	GO:0004713	protein tyrosine kinase activity	Gains
74	GO:0008528	G-protein coupled peptide receptor activity	Gains
74	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
74	GO:0004551	nucleotide diphosphatase activity	Gains
74	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Gains
74	GO:0001653	peptide receptor activity	Gains
74	GO:0004497	monooxygenase activity	Gains
74	GO:0008324	cation transmembrane transporter activity	Gains
74	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	Gains
74	GO:0008188	neuropeptide receptor activity	Gains
74	GO:0005549	odorant binding	Gains
74	GO:0004806	triglyceride lipase activity	Gains
74	GO:0090599	alpha-glucosidase activity	Gains
74	GO:0004984	olfactory receptor activity	Gains
74	GO:0004364	glutathione transferase activity	Gains
74	GO:0016209	antioxidant activity	Gains
74	GO:0015101	organic cation transmembrane transporter activity	Gains
74	GO:0070891	lipoteichoic acid binding	Gains
74	GO:0010484	H3 histone acetyltransferase activity	Gains
74	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
74	GO:0008036	diuretic hormone receptor activity	Gains
74	GO:0032453	histone demethylase activity (H3-K4 specific)	Gains
74	GO:0001530	lipopolysaccharide binding	Gains
74	GO:0005000	vasopressin receptor activity	Gains
74	GO:0042162	telomeric DNA binding	Gains
74	GO:0030882	lipid antigen binding	Gains
74	GO:0015925	galactosidase activity	Gains
74	GO:0004948	calcitonin receptor activity	Gains
74	GO:0005452	inorganic anion exchanger activity	Gains
74	GO:0097642	calcitonin family receptor activity	Gains
74	GO:0004866	endopeptidase inhibitor activity	Gains
74	GO:0032440	2-alkenal reductase [NAD(P)] activity	Gains
74	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
74	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
74	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
74	GO:0015926	glucosidase activity	Gains
74	GO:0005381	iron ion transmembrane transporter activity	Gains
74	GO:0070330	aromatase activity	Gains
74	GO:0061135	endopeptidase regulator activity	Gains
74	GO:0019199	transmembrane receptor protein kinase activity	Gains
74	GO:0022857	transmembrane transporter activity	Gains
74	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
74	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
74	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
74	GO:0046915	transition metal ion transmembrane transporter activity	Gains
74	GO:0030955	potassium ion binding	Gains
74	GO:0031420	alkali metal ion binding	Gains
74	GO:0004743	pyruvate kinase activity	Gains
74	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Gains
74	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Gains
74	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
74	GO:0099106	ion channel regulator activity	Gains
74	GO:0005158	insulin receptor binding	Gains
74	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
74	GO:0003823	antigen binding	Gains
74	GO:0004601	peroxidase activity	Novel expansions
74	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Novel expansions
74	GO:0016209	antioxidant activity	Novel expansions
74	GO:0004307	ethanolaminephosphotransferase activity	Novel expansions
74	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	Novel expansions
74	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Novel expansions
74	GO:0020037	heme binding	Novel expansions
74	GO:0046906	tetrapyrrole binding	Novel expansions
74	GO:0017169	CDP-alcohol phosphatidyltransferase activity	Novel expansions
74	GO:0061783	peptidoglycan muralytic activity	Novel expansions
74	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Novel expansions
73	GO:0003964	RNA-directed DNA polymerase activity	Gains
73	GO:0034061	DNA polymerase activity	Gains
73	GO:0140097	catalytic activity, acting on DNA	Gains
73	GO:0016779	nucleotidyltransferase activity	Gains
73	GO:0070001	aspartic-type peptidase activity	Gains
73	GO:0004190	aspartic-type endopeptidase activity	Gains
73	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
73	GO:0099600	transmembrane receptor activity	Gains
73	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
73	GO:0004888	transmembrane signaling receptor activity	Gains
73	GO:0008417	fucosyltransferase activity	Gains
73	GO:0003676	nucleic acid binding	Gains
73	GO:0004872	receptor activity	Gains
73	GO:0004518	nuclease activity	Gains
73	GO:0004519	endonuclease activity	Gains
73	GO:0004803	transposase activity	Gains
73	GO:0015276	ligand-gated ion channel activity	Gains
73	GO:0022834	ligand-gated channel activity	Gains
73	GO:0060089	molecular transducer activity	Gains
73	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Gains
73	GO:0016151	nickel cation binding	Gains
73	GO:0038023	signaling receptor activity	Gains
73	GO:0005230	extracellular ligand-gated ion channel activity	Gains
73	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
73	GO:0004930	G-protein coupled receptor activity	Gains
73	GO:0016788	hydrolase activity, acting on ester bonds	Gains
73	GO:0004713	protein tyrosine kinase activity	Gains
73	GO:0004871	signal transducer activity	Gains
73	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
73	GO:0003677	DNA binding	Gains
73	GO:0004175	endopeptidase activity	Gains
73	GO:0004521	endoribonuclease activity	Gains
73	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
73	GO:0008083	growth factor activity	Gains
73	GO:0004252	serine-type endopeptidase activity	Gains
73	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
73	GO:0004383	guanylate cyclase activity	Gains
73	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
73	GO:0097747	RNA polymerase activity	Gains
73	GO:0034062	5'-3' RNA polymerase activity	Gains
73	GO:0015267	channel activity	Gains
73	GO:0022803	passive transmembrane transporter activity	Gains
73	GO:0003777	microtubule motor activity	Gains
73	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
73	GO:0005216	ion channel activity	Gains
73	GO:0004866	endopeptidase inhibitor activity	Gains
73	GO:0022838	substrate-specific channel activity	Gains
73	GO:0022836	gated channel activity	Gains
73	GO:0030414	peptidase inhibitor activity	Gains
73	GO:0016740	transferase activity	Gains
73	GO:0016917	GABA receptor activity	Gains
73	GO:0004736	pyruvate carboxylase activity	Gains
73	GO:0015928	fucosidase activity	Gains
73	GO:0004890	GABA-A receptor activity	Gains
73	GO:0004560	alpha-L-fucosidase activity	Gains
73	GO:0003939	L-iditol 2-dehydrogenase activity	Gains
73	GO:0036122	BMP binding	Gains
73	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Gains
73	GO:0032135	DNA insertion or deletion binding	Gains
73	GO:0032137	guanine/thymine mispair binding	Gains
73	GO:0032138	single base insertion or deletion binding	Gains
73	GO:0005314	high-affinity glutamate transmembrane transporter activity	Gains
73	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Gains
73	GO:0004372	glycine hydroxymethyltransferase activity	Gains
73	GO:0035197	siRNA binding	Gains
73	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Gains
73	GO:0019199	transmembrane receptor protein kinase activity	Gains
73	GO:0016849	phosphorus-oxygen lyase activity	Gains
73	GO:0017048	Rho GTPase binding	Gains
73	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
73	GO:0015172	acidic amino acid transmembrane transporter activity	Gains
73	GO:0004075	biotin carboxylase activity	Gains
73	GO:0019825	oxygen binding	Gains
73	GO:0005313	L-glutamate transmembrane transporter activity	Gains
73	GO:0019955	cytokine binding	Gains
73	GO:0061135	endopeptidase regulator activity	Gains
73	GO:0035251	UDP-glucosyltransferase activity	Gains
73	GO:0008233	peptidase activity	Gains
73	GO:0097159	organic cyclic compound binding	Gains
73	GO:0009975	cyclase activity	Gains
73	GO:1901363	heterocyclic compound binding	Gains
73	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
73	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
73	GO:0005342	organic acid transmembrane transporter activity	Gains
73	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
73	GO:0017171	serine hydrolase activity	Gains
73	GO:0008527	taste receptor activity	Losses
73	GO:0031409	pigment binding	Losses
73	GO:0046914	transition metal ion binding	Losses
73	GO:0008395	steroid hydroxylase activity	Losses
73	GO:0070330	aromatase activity	Losses
73	GO:0140104	molecular carrier activity	Losses
73	GO:0005381	iron ion transmembrane transporter activity	Losses
73	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
73	GO:0052745	inositol phosphate phosphatase activity	Losses
73	GO:0005215	transporter activity	Losses
73	GO:0042302	structural constituent of cuticle	Losses
73	GO:0031177	phosphopantetheine binding	Losses
73	GO:0044620	ACP phosphopantetheine attachment site binding	Losses
73	GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
73	GO:0019113	limonene monooxygenase activity	Losses
73	GO:0008031	eclosion hormone activity	Losses
73	GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Losses
73	GO:0035650	AP-1 adaptor complex binding	Losses
73	GO:0034584	piRNA binding	Losses
73	GO:0004099	chitin deacetylase activity	Losses
73	GO:0072320	volume-sensitive chloride channel activity	Losses
73	GO:0000036	acyl carrier activity	Losses
73	GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
73	GO:0051192	prosthetic group binding	Losses
73	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Losses
73	GO:0004446	inositol-hexakisphosphate phosphatase activity	Losses
73	GO:0035302	ecdysteroid 25-hydroxylase activity	Losses
73	GO:0003839	gamma-glutamylcyclotransferase activity	Losses
73	GO:0005225	volume-sensitive anion channel activity	Losses
73	GO:0008511	sodium:potassium:chloride symporter activity	Losses
73	GO:0022853	active ion transmembrane transporter activity	Losses
73	GO:0015108	chloride transmembrane transporter activity	Losses
73	GO:0008270	zinc ion binding	Losses
73	GO:0005507	copper ion binding	Losses
73	GO:0046915	transition metal ion transmembrane transporter activity	Losses
73	GO:0005214	structural constituent of chitin-based cuticle	Losses
73	GO:0008061	chitin binding	Losses
73	GO:0022857	transmembrane transporter activity	Losses
73	GO:0022892	substrate-specific transporter activity	Losses
73	GO:0004497	monooxygenase activity	Losses
73	GO:0022891	substrate-specific transmembrane transporter activity	Losses
73	GO:0016531	copper chaperone activity	Losses
73	GO:0015377	cation:chloride symporter activity	Losses
73	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
73	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
73	GO:0015417	polyamine-transporting ATPase activity	Losses
73	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
73	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
73	GO:0052834	inositol monophosphate phosphatase activity	Losses
73	GO:0015203	polyamine transmembrane transporter activity	Losses
73	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Losses
73	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Losses
73	GO:0008260	3-oxoacid CoA-transferase activity	Losses
73	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	Losses
73	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
73	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Losses
73	GO:0005272	sodium channel activity	Losses
73	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
73	GO:0016849	phosphorus-oxygen lyase activity	Losses
73	GO:0043492	ATPase activity, coupled to movement of substances	Losses
73	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
73	GO:0015075	ion transmembrane transporter activity	Losses
73	GO:0097747	RNA polymerase activity	Losses
73	GO:0034062	5'-3' RNA polymerase activity	Losses
73	GO:0016491	oxidoreductase activity	Losses
73	GO:0015399	primary active transmembrane transporter activity	Losses
73	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
73	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
73	GO:0009975	cyclase activity	Losses
73	GO:0018454	acetoacetyl-CoA reductase activity	Losses
73	GO:0004504	peptidylglycine monooxygenase activity	Losses
73	GO:0009922	fatty acid elongase activity	Losses
73	GO:0004090	carbonyl reductase (NADPH) activity	Losses
73	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Losses
73	GO:0008410	CoA-transferase activity	Losses
73	GO:0004344	glucose dehydrogenase activity	Losses
73	GO:0050321	tau-protein kinase activity	Losses
73	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Losses
73	GO:0008812	choline dehydrogenase activity	Losses
73	GO:0050333	thiamin-triphosphatase activity	Novel expansions
73	GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
73	GO:0004713	protein tyrosine kinase activity	Novel expansions
73	GO:0015276	ligand-gated ion channel activity	Novel expansions
73	GO:0022834	ligand-gated channel activity	Novel expansions
73	GO:0016151	nickel cation binding	Novel expansions
73	GO:0099600	transmembrane receptor activity	Novel expansions
73	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Novel expansions
73	GO:0022836	gated channel activity	Novel expansions
73	GO:0004872	receptor activity	Novel expansions
73	GO:0060089	molecular transducer activity	Novel expansions
73	GO:0140104	molecular carrier activity	Extinctions
73	GO:0031177	phosphopantetheine binding	Extinctions
73	GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
73	GO:0035650	AP-1 adaptor complex binding	Extinctions
73	GO:0000036	acyl carrier activity	Extinctions
73	GO:0051192	prosthetic group binding	Extinctions
73	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	Extinctions
73	GO:0035302	ecdysteroid 25-hydroxylase activity	Extinctions
73	GO:0003839	gamma-glutamylcyclotransferase activity	Extinctions
73	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
73	GO:0097747	RNA polymerase activity	Extinctions
73	GO:0034062	5'-3' RNA polymerase activity	Extinctions
73	GO:0016531	copper chaperone activity	Extinctions
73	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Extinctions
73	GO:0004090	carbonyl reductase (NADPH) activity	Extinctions
73	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Extinctions
73	GO:0050321	tau-protein kinase activity	Extinctions
73	GO:0004697	protein kinase C activity	Extinctions
73	GO:0042302	structural constituent of cuticle	Extinctions
73	GO:0016530	metallochaperone activity	Extinctions
73	GO:0031625	ubiquitin protein ligase binding	Extinctions
73	GO:0044389	ubiquitin-like protein ligase binding	Extinctions
73	GO:0004012	phospholipid-translocating ATPase activity	Extinctions
73	GO:0008527	taste receptor activity	Extinctions
72	GO:0022824	transmitter-gated ion channel activity	Gains
72	GO:0022835	transmitter-gated channel activity	Gains
72	GO:0004970	ionotropic glutamate receptor activity	Gains
72	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
72	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
72	GO:0008066	glutamate receptor activity	Gains
72	GO:0030594	neurotransmitter receptor activity	Gains
72	GO:0005230	extracellular ligand-gated ion channel activity	Gains
72	GO:0003964	RNA-directed DNA polymerase activity	Gains
72	GO:0022834	ligand-gated channel activity	Gains
72	GO:0015276	ligand-gated ion channel activity	Gains
72	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
72	GO:0070330	aromatase activity	Gains
72	GO:0022857	transmembrane transporter activity	Gains
72	GO:0008756	o-succinylbenzoate-CoA ligase activity	Gains
72	GO:0016779	nucleotidyltransferase activity	Gains
72	GO:0022891	substrate-specific transmembrane transporter activity	Gains
72	GO:0034061	DNA polymerase activity	Gains
72	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Gains
72	GO:0015075	ion transmembrane transporter activity	Gains
72	GO:0020037	heme binding	Gains
72	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
72	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
72	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
72	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
72	GO:0046906	tetrapyrrole binding	Gains
72	GO:0042302	structural constituent of cuticle	Gains
72	GO:0005215	transporter activity	Gains
72	GO:0005216	ion channel activity	Gains
72	GO:0022838	substrate-specific channel activity	Gains
72	GO:0016783	sulfurtransferase activity	Gains
72	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
72	GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
72	GO:0016405	CoA-ligase activity	Gains
72	GO:0022803	passive transmembrane transporter activity	Gains
72	GO:0015267	channel activity	Gains
72	GO:0022836	gated channel activity	Gains
72	GO:0022892	substrate-specific transporter activity	Gains
72	GO:0016746	transferase activity, transferring acyl groups	Gains
72	GO:0016878	acid-thiol ligase activity	Gains
72	GO:1901505	carbohydrate derivative transmembrane transporter activity	Gains
72	GO:0017153	sodium:dicarboxylate symporter activity	Gains
72	GO:0140097	catalytic activity, acting on DNA	Gains
72	GO:0008061	chitin binding	Gains
72	GO:0005214	structural constituent of chitin-based cuticle	Gains
72	GO:0016877	ligase activity, forming carbon-sulfur bonds	Gains
72	GO:0004104	cholinesterase activity	Gains
72	GO:0015645	fatty acid ligase activity	Gains
72	GO:0003990	acetylcholinesterase activity	Gains
72	GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
72	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
72	GO:0004497	monooxygenase activity	Gains
72	GO:0047915	ganglioside galactosyltransferase activity	Gains
72	GO:1901682	sulfur compound transmembrane transporter activity	Gains
72	GO:0016411	acylglycerol O-acyltransferase activity	Gains
72	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
72	GO:0005342	organic acid transmembrane transporter activity	Gains
72	GO:0046943	carboxylic acid transmembrane transporter activity	Gains
72	GO:0015144	carbohydrate transmembrane transporter activity	Gains
72	GO:0051119	sugar transmembrane transporter activity	Gains
72	GO:0015291	secondary active transmembrane transporter activity	Gains
72	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
72	GO:0042947	glucoside transmembrane transporter activity	Gains
72	GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase	Gains
72	GO:0008836	diaminopimelate decarboxylase activity	Gains
72	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Gains
72	GO:0043682	copper-transporting ATPase activity	Gains
72	GO:0004757	sepiapterin reductase activity	Gains
72	GO:0097493	structural molecule activity conferring elasticity	Gains
72	GO:0050897	cobalt ion binding	Gains
72	GO:0004557	alpha-galactosidase activity	Gains
72	GO:0004586	ornithine decarboxylase activity	Gains
72	GO:0003998	acylphosphatase activity	Gains
72	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity	Gains
72	GO:0003942	N-acetyl-gamma-glutamyl-phosphate reductase activity	Gains
72	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
72	GO:0004666	prostaglandin-endoperoxide synthase activity	Gains
72	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
72	GO:0004605	phosphatidate cytidylyltransferase activity	Gains
72	GO:0052692	raffinose alpha-galactosidase activity	Gains
72	GO:0015499	formate transmembrane transporter activity	Gains
72	GO:0004072	aspartate kinase activity	Gains
72	GO:0047200	tetrahydrodipicolinate N-acetyltransferase activity	Gains
72	GO:0004008	copper-exporting ATPase activity	Gains
72	GO:0015151	alpha-glucoside transmembrane transporter activity	Gains
72	GO:0015106	bicarbonate transmembrane transporter activity	Gains
72	GO:0008456	alpha-N-acetylgalactosaminidase activity	Gains
72	GO:0005368	taurine transmembrane transporter activity	Gains
72	GO:0005369	taurine:sodium symporter activity	Gains
72	GO:0019531	oxalate transmembrane transporter activity	Gains
72	GO:0004321	fatty-acyl-CoA synthase activity	Gains
72	GO:0046981	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity	Gains
72	GO:0004493	methylmalonyl-CoA epimerase activity	Gains
72	GO:0008777	acetylornithine deacetylase activity	Gains
72	GO:0015574	trehalose transmembrane transporter activity	Gains
72	GO:0016209	antioxidant activity	Gains
72	GO:0005506	iron ion binding	Gains
72	GO:0008236	serine-type peptidase activity	Gains
72	GO:0017171	serine hydrolase activity	Gains
72	GO:0005343	organic acid:sodium symporter activity	Gains
72	GO:0008514	organic anion transmembrane transporter activity	Gains
72	GO:0015294	solute:cation symporter activity	Gains
72	GO:0004871	signal transducer activity	Losses
72	GO:0004872	receptor activity	Losses
72	GO:0038023	signaling receptor activity	Losses
72	GO:0060089	molecular transducer activity	Losses
72	GO:0046873	metal ion transmembrane transporter activity	Losses
72	GO:0022890	inorganic cation transmembrane transporter activity	Losses
72	GO:0008324	cation transmembrane transporter activity	Losses
72	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
72	GO:0099600	transmembrane receptor activity	Losses
72	GO:0015079	potassium ion transmembrane transporter activity	Losses
72	GO:0019199	transmembrane receptor protein kinase activity	Losses
72	GO:0005267	potassium channel activity	Losses
72	GO:0005500	juvenile hormone binding	Losses
72	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	Losses
72	GO:0004888	transmembrane signaling receptor activity	Losses
72	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
72	GO:0005102	receptor binding	Losses
72	GO:0015075	ion transmembrane transporter activity	Losses
72	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Losses
72	GO:0005515	protein binding	Losses
72	GO:0022836	gated channel activity	Losses
72	GO:0043169	cation binding	Losses
72	GO:0022843	voltage-gated cation channel activity	Losses
72	GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Losses
72	GO:0047429	nucleoside-triphosphate diphosphatase activity	Losses
72	GO:0032453	histone demethylase activity (H3-K4 specific)	Losses
72	GO:0005249	voltage-gated potassium channel activity	Losses
72	GO:0005261	cation channel activity	Losses
72	GO:0022857	transmembrane transporter activity	Losses
72	GO:0099094	ligand-gated cation channel activity	Losses
72	GO:0042562	hormone binding	Losses
72	GO:0046872	metal ion binding	Losses
72	GO:0005509	calcium ion binding	Losses
72	GO:0022891	substrate-specific transmembrane transporter activity	Losses
72	GO:0004197	cysteine-type endopeptidase activity	Losses
72	GO:0022804	active transmembrane transporter activity	Losses
72	GO:0005244	voltage-gated ion channel activity	Losses
72	GO:0022832	voltage-gated channel activity	Losses
72	GO:0004497	monooxygenase activity	Losses
72	GO:0005506	iron ion binding	Losses
72	GO:0005544	calcium-dependent phospholipid binding	Losses
72	GO:0042169	SH2 domain binding	Losses
72	GO:0008013	beta-catenin binding	Losses
72	GO:0032451	demethylase activity	Losses
72	GO:0032452	histone demethylase activity	Losses
72	GO:0019840	isoprenoid binding	Losses
72	GO:0008199	ferric iron binding	Losses
72	GO:0015294	solute:cation symporter activity	Losses
72	GO:0015081	sodium ion transmembrane transporter activity	Losses
72	GO:0015108	chloride transmembrane transporter activity	Losses
72	GO:0046914	transition metal ion binding	Losses
72	GO:0016301	kinase activity	Losses
72	GO:0004672	protein kinase activity	Losses
72	GO:0022892	substrate-specific transporter activity	Losses
72	GO:0015103	inorganic anion transmembrane transporter activity	Losses
72	GO:0008395	steroid hydroxylase activity	Losses
72	GO:0005328	neurotransmitter:sodium symporter activity	Losses
72	GO:0015291	secondary active transmembrane transporter activity	Losses
72	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Losses
72	GO:0022853	active ion transmembrane transporter activity	Losses
72	GO:0004713	protein tyrosine kinase activity	Losses
72	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
72	GO:0005216	ion channel activity	Losses
72	GO:0022838	substrate-specific channel activity	Losses
72	GO:0070491	repressing transcription factor binding	Losses
72	GO:0005215	transporter activity	Losses
72	GO:0008134	transcription factor binding	Losses
72	GO:0005225	volume-sensitive anion channel activity	Losses
72	GO:0043559	insulin binding	Losses
72	GO:0008892	guanine deaminase activity	Losses
72	GO:0008865	fructokinase activity	Losses
72	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
72	GO:0016743	carboxyl- or carbamoyltransferase activity	Losses
72	GO:0008579	JUN kinase phosphatase activity	Losses
72	GO:0008511	sodium:potassium:chloride symporter activity	Losses
72	GO:0050840	extracellular matrix binding	Losses
72	GO:0017151	DEAD/H-box RNA helicase binding	Losses
72	GO:0015088	copper uptake transmembrane transporter activity	Losses
72	GO:0050564	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity	Losses
72	GO:0005534	galactose binding	Losses
72	GO:0001784	phosphotyrosine residue binding	Losses
72	GO:0016531	copper chaperone activity	Losses
72	GO:0016532	superoxide dismutase copper chaperone activity	Losses
72	GO:0004598	peptidylamidoglycolate lyase activity	Losses
72	GO:0043047	single-stranded telomeric DNA binding	Losses
72	GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Losses
72	GO:0050699	WW domain binding	Losses
72	GO:0003985	acetyl-CoA C-acetyltransferase activity	Losses
72	GO:0003986	acetyl-CoA hydrolase activity	Losses
72	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Losses
72	GO:0004503	monophenol monooxygenase activity	Losses
72	GO:0008068	extracellularly glutamate-gated chloride channel activity	Losses
72	GO:0047493	ceramide cholinephosphotransferase activity	Losses
72	GO:0030159	receptor signaling complex scaffold activity	Losses
72	GO:0001586	Gi/o-coupled serotonin receptor activity	Losses
72	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Losses
72	GO:0046875	ephrin receptor binding	Losses
72	GO:0019158	mannokinase activity	Losses
72	GO:0008927	mannonate dehydratase activity	Losses
72	GO:0051010	microtubule plus-end binding	Losses
72	GO:0019135	deoxyhypusine monooxygenase activity	Losses
72	GO:0072320	volume-sensitive chloride channel activity	Losses
72	GO:0036263	L-DOPA monooxygenase activity	Losses
72	GO:0036264	dopamine monooxygenase activity	Losses
72	GO:0042767	ecdysteroid 22-hydroxylase activity	Losses
72	GO:0005009	insulin-activated receptor activity	Losses
72	GO:0004097	catechol oxidase activity	Losses
72	GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity	Losses
72	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity	Losses
72	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	Losses
72	GO:0004070	aspartate carbamoyltransferase activity	Losses
72	GO:0004971	AMPA glutamate receptor activity	Losses
72	GO:0015277	kainate selective glutamate receptor activity	Losses
72	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
72	GO:0047880	erythrulose reductase activity	Losses
72	GO:0035013	myosuppressin receptor activity	Losses
72	GO:0045309	protein phosphorylated amino acid binding	Losses
72	GO:0051425	PTB domain binding	Losses
72	GO:0080023	3R-hydroxyacyl-CoA dehydratase activity	Losses
72	GO:0004396	hexokinase activity	Losses
72	GO:0098847	sequence-specific single stranded DNA binding	Losses
72	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
72	GO:0004340	glucokinase activity	Losses
72	GO:0004334	fumarylacetoacetase activity	Losses
72	GO:0004454	ketohexokinase activity	Losses
72	GO:0033192	calmodulin-dependent protein phosphatase activity	Losses
72	GO:0047623	adenosine-phosphate deaminase activity	Losses
72	GO:0033188	sphingomyelin synthase activity	Losses
72	GO:0003876	AMP deaminase activity	Losses
72	GO:0003844	1,4-alpha-glucan branching enzyme activity	Losses
72	GO:0004151	dihydroorotase activity	Losses
72	GO:0004170	dUTP diphosphatase activity	Losses
72	GO:0043560	insulin receptor substrate binding	Losses
72	GO:0022824	transmitter-gated ion channel activity	Novel expansions
72	GO:0022835	transmitter-gated channel activity	Novel expansions
72	GO:0004970	ionotropic glutamate receptor activity	Novel expansions
72	GO:0005234	extracellularly glutamate-gated ion channel activity	Novel expansions
72	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Novel expansions
72	GO:0008066	glutamate receptor activity	Novel expansions
72	GO:0030594	neurotransmitter receptor activity	Novel expansions
72	GO:0005230	extracellular ligand-gated ion channel activity	Novel expansions
72	GO:0022834	ligand-gated channel activity	Novel expansions
72	GO:0015276	ligand-gated ion channel activity	Novel expansions
72	GO:0008756	o-succinylbenzoate-CoA ligase activity	Novel expansions
72	GO:0016877	ligase activity, forming carbon-sulfur bonds	Novel expansions
72	GO:0022836	gated channel activity	Novel expansions
72	GO:0016405	CoA-ligase activity	Novel expansions
72	GO:0016878	acid-thiol ligase activity	Novel expansions
72	GO:0005216	ion channel activity	Novel expansions
72	GO:0022838	substrate-specific channel activity	Novel expansions
72	GO:0022803	passive transmembrane transporter activity	Novel expansions
72	GO:0015267	channel activity	Novel expansions
72	GO:0022857	transmembrane transporter activity	Novel expansions
72	GO:0005215	transporter activity	Novel expansions
72	GO:0015075	ion transmembrane transporter activity	Novel expansions
72	GO:0004703	G-protein coupled receptor kinase activity	Novel expansions
72	GO:0017153	sodium:dicarboxylate symporter activity	Novel expansions
72	GO:0015645	fatty acid ligase activity	Novel expansions
72	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Novel expansions
72	GO:0004784	superoxide dismutase activity	Novel expansions
72	GO:0004467	long-chain fatty acid-CoA ligase activity	Novel expansions
72	GO:0004888	transmembrane signaling receptor activity	Novel expansions
72	GO:0047915	ganglioside galactosyltransferase activity	Novel expansions
72	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Novel expansions
72	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Novel expansions
72	GO:0016174	NAD(P)H oxidase activity	Novel expansions
72	GO:0022891	substrate-specific transmembrane transporter activity	Novel expansions
72	GO:0099600	transmembrane receptor activity	Novel expansions
72	GO:0004525	ribonuclease III activity	Novel expansions
72	GO:0032296	double-stranded RNA-specific ribonuclease activity	Novel expansions
72	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
72	GO:0008892	guanine deaminase activity	Extinctions
72	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Extinctions
72	GO:0016531	copper chaperone activity	Extinctions
72	GO:0016532	superoxide dismutase copper chaperone activity	Extinctions
72	GO:0043047	single-stranded telomeric DNA binding	Extinctions
72	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Extinctions
72	GO:0004503	monophenol monooxygenase activity	Extinctions
72	GO:0008927	mannonate dehydratase activity	Extinctions
72	GO:0019135	deoxyhypusine monooxygenase activity	Extinctions
72	GO:0036263	L-DOPA monooxygenase activity	Extinctions
72	GO:0036264	dopamine monooxygenase activity	Extinctions
72	GO:0004097	catechol oxidase activity	Extinctions
72	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
72	GO:0098847	sequence-specific single stranded DNA binding	Extinctions
72	GO:0004454	ketohexokinase activity	Extinctions
72	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
72	GO:0005549	odorant binding	Extinctions
72	GO:0008020	G-protein coupled photoreceptor activity	Extinctions
72	GO:0015417	polyamine-transporting ATPase activity	Extinctions
72	GO:0015203	polyamine transmembrane transporter activity	Extinctions
72	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Extinctions
72	GO:0004771	sterol esterase activity	Extinctions
72	GO:0016530	metallochaperone activity	Extinctions
72	GO:0042162	telomeric DNA binding	Extinctions
72	GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
72	GO:0042625	ATPase coupled ion transmembrane transporter activity	Extinctions
72	GO:0043169	cation binding	Extinctions
72	GO:0036442	hydrogen-exporting ATPase activity	Extinctions
72	GO:0004872	receptor activity	Extinctions
71	GO:0005509	calcium ion binding	Gains
71	GO:0004871	signal transducer activity	Gains
71	GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
71	GO:0046872	metal ion binding	Gains
71	GO:0004888	transmembrane signaling receptor activity	Gains
71	GO:0005085	guanyl-nucleotide exchange factor activity	Gains
71	GO:0043169	cation binding	Gains
71	GO:0017016	Ras GTPase binding	Gains
71	GO:0004872	receptor activity	Gains
71	GO:0099600	transmembrane receptor activity	Gains
71	GO:0031267	small GTPase binding	Gains
71	GO:0003964	RNA-directed DNA polymerase activity	Gains
71	GO:0005488	binding	Gains
71	GO:0060089	molecular transducer activity	Gains
71	GO:0003774	motor activity	Gains
71	GO:0005261	cation channel activity	Gains
71	GO:0017048	Rho GTPase binding	Gains
71	GO:0004672	protein kinase activity	Gains
71	GO:0038023	signaling receptor activity	Gains
71	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
71	GO:0051020	GTPase binding	Gains
71	GO:0022836	gated channel activity	Gains
71	GO:0015085	calcium ion transmembrane transporter activity	Gains
71	GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
71	GO:0005244	voltage-gated ion channel activity	Gains
71	GO:0022832	voltage-gated channel activity	Gains
71	GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
71	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
71	GO:0022838	substrate-specific channel activity	Gains
71	GO:0005267	potassium channel activity	Gains
71	GO:0019899	enzyme binding	Gains
71	GO:0022843	voltage-gated cation channel activity	Gains
71	GO:0005249	voltage-gated potassium channel activity	Gains
71	GO:0004725	protein tyrosine phosphatase activity	Gains
71	GO:0022803	passive transmembrane transporter activity	Gains
71	GO:0015267	channel activity	Gains
71	GO:0005216	ion channel activity	Gains
71	GO:0046873	metal ion transmembrane transporter activity	Gains
71	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Gains
71	GO:0019198	transmembrane receptor protein phosphatase activity	Gains
71	GO:0016301	kinase activity	Gains
71	GO:0098772	molecular function regulator	Gains
71	GO:0015079	potassium ion transmembrane transporter activity	Gains
71	GO:0008270	zinc ion binding	Gains
71	GO:0034061	DNA polymerase activity	Gains
71	GO:0003777	microtubule motor activity	Gains
71	GO:0046914	transition metal ion binding	Gains
71	GO:0008017	microtubule binding	Gains
71	GO:0015631	tubulin binding	Gains
71	GO:0008237	metallopeptidase activity	Gains
71	GO:0005516	calmodulin binding	Gains
71	GO:0050254	rhodopsin kinase activity	Gains
71	GO:0005096	GTPase activator activity	Gains
71	GO:0005262	calcium channel activity	Gains
71	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
71	GO:0004222	metalloendopeptidase activity	Gains
71	GO:0043167	ion binding	Gains
71	GO:0050839	cell adhesion molecule binding	Gains
71	GO:0004930	G-protein coupled receptor activity	Gains
71	GO:0005515	protein binding	Gains
71	GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
71	GO:0005388	calcium-transporting ATPase activity	Gains
71	GO:0004674	protein serine/threonine kinase activity	Gains
71	GO:0019199	transmembrane receptor protein kinase activity	Gains
71	GO:0015103	inorganic anion transmembrane transporter activity	Gains
71	GO:0005057	signal transducer activity, downstream of receptor	Gains
71	GO:0043565	sequence-specific DNA binding	Gains
71	GO:0030695	GTPase regulator activity	Gains
71	GO:0003700	DNA binding transcription factor activity	Gains
71	GO:0008092	cytoskeletal protein binding	Gains
71	GO:0008047	enzyme activator activity	Gains
71	GO:0099604	ligand-gated calcium channel activity	Gains
71	GO:0015278	calcium-release channel activity	Gains
71	GO:0004803	transposase activity	Gains
71	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
71	GO:0004385	guanylate kinase activity	Gains
71	GO:0005543	phospholipid binding	Gains
71	GO:0060090	molecular adaptor activity	Gains
71	GO:0005248	voltage-gated sodium channel activity	Gains
71	GO:0008525	phosphatidylcholine transporter activity	Gains
71	GO:0004711	ribosomal protein S6 kinase activity	Gains
71	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
71	GO:0035174	histone serine kinase activity	Gains
71	GO:0003987	acetate-CoA ligase activity	Gains
71	GO:0022833	mechanically gated channel activity	Gains
71	GO:1905030	voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential	Gains
71	GO:0030151	molybdenum ion binding	Gains
71	GO:0008381	mechanically-gated ion channel activity	Gains
71	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	Gains
71	GO:0004415	hyalurononglucosaminidase activity	Gains
71	GO:0030620	U2 snRNA binding	Gains
71	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Gains
71	GO:0099094	ligand-gated cation channel activity	Gains
71	GO:0030234	enzyme regulator activity	Gains
71	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Gains
71	GO:0101005	ubiquitinyl hydrolase activity	Gains
71	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Gains
71	GO:0004622	lysophospholipase activity	Gains
71	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
71	GO:0005452	inorganic anion exchanger activity	Gains
71	GO:0008266	poly(U) RNA binding	Gains
71	GO:0016788	hydrolase activity, acting on ester bonds	Gains
71	GO:1990837	sequence-specific double-stranded DNA binding	Gains
71	GO:0004721	phosphoprotein phosphatase activity	Gains
71	GO:0060589	nucleoside-triphosphatase regulator activity	Gains
71	GO:0005102	receptor binding	Gains
71	GO:0070891	lipoteichoic acid binding	Losses
71	GO:0001530	lipopolysaccharide binding	Losses
71	GO:0030882	lipid antigen binding	Losses
71	GO:0008527	taste receptor activity	Losses
71	GO:0003823	antigen binding	Losses
71	GO:0004312	fatty acid synthase activity	Losses
71	GO:0004104	cholinesterase activity	Losses
71	GO:0003990	acetylcholinesterase activity	Losses
71	GO:0042834	peptidoglycan binding	Losses
71	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	Losses
71	GO:0008028	monocarboxylic acid transmembrane transporter activity	Losses
71	GO:0016860	intramolecular oxidoreductase activity	Losses
71	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
71	GO:0004984	olfactory receptor activity	Losses
71	GO:0016763	transferase activity, transferring pentosyl groups	Losses
71	GO:0004602	glutathione peroxidase activity	Losses
71	GO:0018800	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	Losses
71	GO:0019531	oxalate transmembrane transporter activity	Losses
71	GO:0004769	steroid delta-isomerase activity	Losses
71	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Losses
71	GO:0000293	ferric-chelate reductase activity	Losses
71	GO:0004850	uridine phosphorylase activity	Losses
71	GO:0033897	ribonuclease T2 activity	Losses
71	GO:0004531	deoxyribonuclease II activity	Losses
71	GO:0004667	prostaglandin-D synthase activity	Losses
71	GO:0008940	nitrate reductase activity	Losses
71	GO:0047316	glutamine-phenylpyruvate transaminase activity	Losses
71	GO:0008903	hydroxypyruvate isomerase activity	Losses
71	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
71	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
71	GO:0047407	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	Losses
71	GO:0034584	piRNA binding	Losses
71	GO:0015499	formate transmembrane transporter activity	Losses
71	GO:0005347	ATP transmembrane transporter activity	Losses
71	GO:0004321	fatty-acyl-CoA synthase activity	Losses
71	GO:0005471	ATP:ADP antiporter activity	Losses
71	GO:0004339	glucan 1,4-alpha-glucosidase activity	Losses
71	GO:0047804	cysteine-S-conjugate beta-lyase activity	Losses
71	GO:0015106	bicarbonate transmembrane transporter activity	Losses
71	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Losses
71	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Losses
71	GO:0009703	nitrate reductase (NADH) activity	Losses
71	GO:0008768	UDP-sugar diphosphatase activity	Losses
71	GO:0015217	ADP transmembrane transporter activity	Losses
71	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Losses
71	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Losses
71	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Losses
71	GO:0004145	diamine N-acetyltransferase activity	Losses
71	GO:0008704	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	Losses
71	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
71	GO:0008289	lipid binding	Losses
71	GO:0016209	antioxidant activity	Losses
71	GO:0016491	oxidoreductase activity	Losses
71	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
71	GO:0005549	odorant binding	Losses
71	GO:0015002	heme-copper terminal oxidase activity	Losses
71	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
71	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
71	GO:0000049	tRNA binding	Losses
71	GO:0004129	cytochrome-c oxidase activity	Losses
71	GO:0050833	pyruvate transmembrane transporter activity	Losses
71	GO:0004745	retinol dehydrogenase activity	Losses
71	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Losses
71	GO:0000295	adenine nucleotide transmembrane transporter activity	Losses
71	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Losses
71	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Losses
71	GO:0031386	protein tag	Losses
71	GO:0045552	dihydrokaempferol 4-reductase activity	Losses
71	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	Losses
71	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Losses
71	GO:0070548	L-glutamine aminotransferase activity	Losses
71	GO:0033041	sweet taste receptor activity	Losses
71	GO:0008460	dTDP-glucose 4,6-dehydratase activity	Losses
71	GO:0015301	anion:anion antiporter activity	Losses
71	GO:0005346	purine ribonucleotide transmembrane transporter activity	Losses
71	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	Losses
71	GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
71	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Losses
71	GO:0015215	nucleotide transmembrane transporter activity	Losses
71	GO:0015216	purine nucleotide transmembrane transporter activity	Losses
71	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
71	GO:0008514	organic anion transmembrane transporter activity	Losses
71	GO:0004767	sphingomyelin phosphodiesterase activity	Losses
71	GO:0003697	single-stranded DNA binding	Losses
71	GO:0004791	thioredoxin-disulfide reductase activity	Novel expansions
71	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Novel expansions
71	GO:0050661	NADP binding	Novel expansions
71	GO:0015036	disulfide oxidoreductase activity	Novel expansions
71	GO:0016209	antioxidant activity	Novel expansions
71	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Novel expansions
71	GO:0050660	flavin adenine dinucleotide binding	Novel expansions
71	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Novel expansions
71	GO:0050662	coenzyme binding	Novel expansions
71	GO:0043168	anion binding	Novel expansions
71	GO:0004386	helicase activity	Novel expansions
71	GO:0000166	nucleotide binding	Novel expansions
71	GO:1901265	nucleoside phosphate binding	Novel expansions
71	GO:0036094	small molecule binding	Novel expansions
71	GO:0018800	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	Extinctions
71	GO:0033897	ribonuclease T2 activity	Extinctions
71	GO:0008903	hydroxypyruvate isomerase activity	Extinctions
71	GO:0047407	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	Extinctions
71	GO:0004321	fatty-acyl-CoA synthase activity	Extinctions
71	GO:0008768	UDP-sugar diphosphatase activity	Extinctions
71	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
71	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Extinctions
71	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
71	GO:0004145	diamine N-acetyltransferase activity	Extinctions
71	GO:0008704	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	Extinctions
71	GO:0015002	heme-copper terminal oxidase activity	Extinctions
71	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
71	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
71	GO:0004129	cytochrome-c oxidase activity	Extinctions
71	GO:0043492	ATPase activity, coupled to movement of substances	Extinctions
71	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Extinctions
71	GO:0050833	pyruvate transmembrane transporter activity	Extinctions
71	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Extinctions
71	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Extinctions
71	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Extinctions
71	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	Extinctions
71	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
71	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Extinctions
71	GO:0015399	primary active transmembrane transporter activity	Extinctions
71	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Extinctions
71	GO:0004709	MAP kinase kinase kinase activity	Extinctions
71	GO:0043021	ribonucleoprotein complex binding	Extinctions
71	GO:0016462	pyrophosphatase activity	Extinctions
71	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Extinctions
71	GO:0016817	hydrolase activity, acting on acid anhydrides	Extinctions
71	GO:0008853	exodeoxyribonuclease III activity	Extinctions
71	GO:0004864	protein phosphatase inhibitor activity	Extinctions
71	GO:0004828	serine-tRNA ligase activity	Extinctions
71	GO:0004815	aspartate-tRNA ligase activity	Extinctions
71	GO:0005501	retinoid binding	Extinctions
71	GO:0003945	N-acetyllactosamine synthase activity	Extinctions
71	GO:0004655	porphobilinogen synthase activity	Extinctions
71	GO:0043024	ribosomal small subunit binding	Extinctions
71	GO:0004449	isocitrate dehydrogenase (NAD+) activity	Extinctions
70	GO:0005216	ion channel activity	Gains
70	GO:0022838	substrate-specific channel activity	Gains
70	GO:0005230	extracellular ligand-gated ion channel activity	Gains
70	GO:0015267	channel activity	Gains
70	GO:0022803	passive transmembrane transporter activity	Gains
70	GO:0022836	gated channel activity	Gains
70	GO:0022857	transmembrane transporter activity	Gains
70	GO:0034061	DNA polymerase activity	Gains
70	GO:0015075	ion transmembrane transporter activity	Gains
70	GO:0015276	ligand-gated ion channel activity	Gains
70	GO:0022834	ligand-gated channel activity	Gains
70	GO:0005215	transporter activity	Gains
70	GO:0005267	potassium channel activity	Gains
70	GO:0003964	RNA-directed DNA polymerase activity	Gains
70	GO:0022891	substrate-specific transmembrane transporter activity	Gains
70	GO:0015079	potassium ion transmembrane transporter activity	Gains
70	GO:0004447	iodide peroxidase activity	Gains
70	GO:0140097	catalytic activity, acting on DNA	Gains
70	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
70	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
70	GO:0046873	metal ion transmembrane transporter activity	Gains
70	GO:0022892	substrate-specific transporter activity	Gains
70	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
70	GO:0004035	alkaline phosphatase activity	Gains
70	GO:0015269	calcium-activated potassium channel activity	Gains
70	GO:0005227	calcium activated cation channel activity	Gains
70	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
70	GO:0030594	neurotransmitter receptor activity	Gains
70	GO:0016779	nucleotidyltransferase activity	Gains
70	GO:0019199	transmembrane receptor protein kinase activity	Gains
70	GO:0003887	DNA-directed DNA polymerase activity	Gains
70	GO:0070851	growth factor receptor binding	Gains
70	GO:0042834	peptidoglycan binding	Gains
70	GO:0005154	epidermal growth factor receptor binding	Gains
70	GO:0022839	ion gated channel activity	Gains
70	GO:0005261	cation channel activity	Gains
70	GO:0042393	histone binding	Gains
70	GO:0003700	DNA binding transcription factor activity	Gains
70	GO:0015293	symporter activity	Gains
70	GO:0005253	anion channel activity	Gains
70	GO:0008527	taste receptor activity	Losses
70	GO:0052689	carboxylic ester hydrolase activity	Losses
70	GO:0016787	hydrolase activity	Losses
70	GO:0061505	DNA topoisomerase II activity	Losses
70	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	Losses
70	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Losses
70	GO:0033041	sweet taste receptor activity	Losses
70	GO:0000182	rDNA binding	Losses
70	GO:0038023	signaling receptor activity	Losses
70	GO:0016298	lipase activity	Losses
70	GO:0003916	DNA topoisomerase activity	Losses
70	GO:0004871	signal transducer activity	Losses
70	GO:0035586	purinergic receptor activity	Losses
70	GO:0003696	satellite DNA binding	Losses
70	GO:0009881	photoreceptor activity	Losses
70	GO:0004872	receptor activity	Losses
70	GO:0004888	transmembrane signaling receptor activity	Losses
70	GO:0000155	phosphorelay sensor kinase activity	Losses
70	GO:0004673	protein histidine kinase activity	Losses
70	GO:0060089	molecular transducer activity	Losses
70	GO:0003823	antigen binding	Losses
70	GO:0003677	DNA binding	Losses
70	GO:0099600	transmembrane receptor activity	Losses
70	GO:0004180	carboxypeptidase activity	Losses
70	GO:0004623	phospholipase A2 activity	Losses
70	GO:0004806	triglyceride lipase activity	Losses
70	GO:0016174	NAD(P)H oxidase activity	Losses
70	GO:0019955	cytokine binding	Losses
70	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Losses
70	GO:0008238	exopeptidase activity	Losses
70	GO:0035250	UDP-galactosyltransferase activity	Losses
70	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
70	GO:0015179	L-amino acid transmembrane transporter activity	Losses
70	GO:0047915	ganglioside galactosyltransferase activity	Losses
70	GO:0004526	ribonuclease P activity	Losses
70	GO:0003676	nucleic acid binding	Losses
70	GO:0019239	deaminase activity	Novel expansions
70	GO:0052689	carboxylic ester hydrolase activity	Extinctions
70	GO:0004623	phospholipase A2 activity	Extinctions
70	GO:0008527	taste receptor activity	Extinctions
70	GO:0004526	ribonuclease P activity	Extinctions
70	GO:0008194	UDP-glycosyltransferase activity	Extinctions
70	GO:0008172	S-methyltransferase activity	Extinctions
70	GO:0015020	glucuronosyltransferase activity	Extinctions
70	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
70	GO:0016298	lipase activity	Extinctions
70	GO:0019120	hydrolase activity, acting on acid halide bonds, in C-halide compounds	Extinctions
70	GO:0009378	four-way junction helicase activity	Extinctions
70	GO:0004061	arylformamidase activity	Extinctions
70	GO:0018786	haloalkane dehalogenase activity	Extinctions
70	GO:0050333	thiamin-triphosphatase activity	Extinctions
70	GO:0008196	vitellogenin receptor activity	Extinctions
70	GO:0030544	Hsp70 protein binding	Extinctions
70	GO:0008119	thiopurine S-methyltransferase activity	Extinctions
70	GO:0005460	UDP-glucose transmembrane transporter activity	Extinctions
70	GO:0005461	UDP-glucuronic acid transmembrane transporter activity	Extinctions
70	GO:0004371	glycerone kinase activity	Extinctions
70	GO:0003720	telomerase activity	Extinctions
70	GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
70	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	Extinctions
70	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Extinctions
70	GO:0003833	beta-alanyl-dopamine synthase activity	Extinctions
70	GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	Extinctions
70	GO:0016824	hydrolase activity, acting on acid halide bonds	Extinctions
70	GO:0003941	L-serine ammonia-lyase activity	Extinctions
70	GO:0004803	transposase activity	Extinctions
70	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
70	GO:0016787	hydrolase activity	Extinctions
DMELA	GO:0005534	galactose binding	Gains
DMELA	GO:0004252	serine-type endopeptidase activity	Gains
DMELA	GO:0048029	monosaccharide binding	Gains
DMELA	GO:0017171	serine hydrolase activity	Gains
DMELA	GO:0030246	carbohydrate binding	Gains
DMELA	GO:0008236	serine-type peptidase activity	Gains
DMELA	GO:0050136	NADH dehydrogenase (quinone) activity	Gains
DMELA	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Gains
DMELA	GO:0008233	peptidase activity	Gains
DMELA	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
DMELA	GO:0004867	serine-type endopeptidase inhibitor activity	Gains
DMELA	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
DMELA	GO:0003954	NADH dehydrogenase activity	Gains
DMELA	GO:0004175	endopeptidase activity	Gains
DMELA	GO:0005201	extracellular matrix structural constituent	Gains
DMELA	GO:0009055	electron transfer activity	Gains
DMELA	GO:0022857	transmembrane transporter activity	Gains
DMELA	GO:0015078	hydrogen ion transmembrane transporter activity	Gains
DMELA	GO:0005549	odorant binding	Gains
DMELA	GO:0004866	endopeptidase inhibitor activity	Gains
DMELA	GO:0022891	substrate-specific transmembrane transporter activity	Gains
DMELA	GO:0022890	inorganic cation transmembrane transporter activity	Gains
DMELA	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
DMELA	GO:0004129	cytochrome-c oxidase activity	Gains
DMELA	GO:0015002	heme-copper terminal oxidase activity	Gains
DMELA	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
DMELA	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
DMELA	GO:0061135	endopeptidase regulator activity	Gains
DMELA	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
DMELA	GO:0005215	transporter activity	Gains
DMELA	GO:0005391	sodium:potassium-exchanging ATPase activity	Gains
DMELA	GO:0015075	ion transmembrane transporter activity	Gains
DMELA	GO:0030414	peptidase inhibitor activity	Gains
DMELA	GO:0005507	copper ion binding	Gains
DMELA	GO:0016229	steroid dehydrogenase activity	Gains
DMELA	GO:0046914	transition metal ion binding	Gains
DMELA	GO:0004857	enzyme inhibitor activity	Gains
DMELA	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
DMELA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DMELA	GO:0003774	motor activity	Gains
DMELA	GO:0031683	G-protein beta/gamma-subunit complex binding	Gains
DMELA	GO:0009922	fatty acid elongase activity	Gains
DMELA	GO:0022892	substrate-specific transporter activity	Gains
DMELA	GO:0008324	cation transmembrane transporter activity	Gains
DMELA	GO:0061134	peptidase regulator activity	Gains
DMELA	GO:0008556	potassium-transporting ATPase activity	Gains
DMELA	GO:0099600	transmembrane receptor activity	Gains
DMELA	GO:0004930	G-protein coupled receptor activity	Gains
DMELA	GO:0004312	fatty acid synthase activity	Gains
DMELA	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Gains
DMELA	GO:0004872	receptor activity	Gains
DMELA	GO:0008378	galactosyltransferase activity	Gains
DMELA	GO:0004629	phospholipase C activity	Gains
DMELA	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
DMELA	GO:0032934	sterol binding	Gains
DMELA	GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
DMELA	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
DMELA	GO:0070330	aromatase activity	Gains
DMELA	GO:0004435	phosphatidylinositol phospholipase C activity	Gains
DMELA	GO:0004167	dopachrome isomerase activity	Gains
DMELA	GO:0030544	Hsp70 protein binding	Gains
DMELA	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
DMELA	GO:0052870	tocopherol omega-hydroxylase activity	Gains
DMELA	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
DMELA	GO:0008836	diaminopimelate decarboxylase activity	Gains
DMELA	GO:0097493	structural molecule activity conferring elasticity	Gains
DMELA	GO:0008515	sucrose transmembrane transporter activity	Gains
DMELA	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Gains
DMELA	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
DMELA	GO:0004802	transketolase activity	Gains
DMELA	GO:0018833	DDT-dehydrochlorinase activity	Gains
DMELA	GO:0005537	mannose binding	Gains
DMELA	GO:0004586	ornithine decarboxylase activity	Gains
DMELA	GO:0030023	extracellular matrix constituent conferring elasticity	Gains
DMELA	GO:0003919	FMN adenylyltransferase activity	Gains
DMELA	GO:0047964	glyoxylate reductase activity	Gains
DMELA	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
DMELA	GO:0050357	tropinesterase activity	Gains
DMELA	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Gains
DMELA	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Gains
DMELA	GO:0045503	dynein light chain binding	Gains
DMELA	GO:0004092	carnitine O-acetyltransferase activity	Gains
DMELA	GO:0004060	arylamine N-acetyltransferase activity	Gains
DMELA	GO:0004059	aralkylamine N-acetyltransferase activity	Gains
DMELA	GO:0004034	aldose 1-epimerase activity	Gains
DMELA	GO:0008316	structural constituent of vitelline membrane	Gains
DMELA	GO:0017159	pantetheine hydrolase activity	Gains
DMELA	GO:0050780	dopamine receptor binding	Gains
DMELA	GO:0035804	structural constituent of egg coat	Gains
DMELA	GO:0030267	glyoxylate reductase (NADP) activity	Gains
DMELA	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Gains
DMELA	GO:0031752	D5 dopamine receptor binding	Gains
DMELA	GO:0033038	bitter taste receptor activity	Gains
DMELA	GO:0015081	sodium ion transmembrane transporter activity	Gains
DMELA	GO:0004984	olfactory receptor activity	Gains
DMELA	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Gains
DMELA	GO:0016491	oxidoreductase activity	Gains
DMELA	GO:0015267	channel activity	Gains
DMELA	GO:0022803	passive transmembrane transporter activity	Gains
DMELA	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Gains
DMELA	GO:0005328	neurotransmitter:sodium symporter activity	Gains
DMELA	GO:0003964	RNA-directed DNA polymerase activity	Losses
DMELA	GO:0034061	DNA polymerase activity	Losses
DMELA	GO:0004190	aspartic-type endopeptidase activity	Losses
DMELA	GO:0070001	aspartic-type peptidase activity	Losses
DMELA	GO:0140097	catalytic activity, acting on DNA	Losses
DMELA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DMELA	GO:0016779	nucleotidyltransferase activity	Losses
DMELA	GO:0046914	transition metal ion binding	Losses
DMELA	GO:0008233	peptidase activity	Losses
DMELA	GO:0008270	zinc ion binding	Losses
DMELA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DMELA	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
DMELA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
DMELA	GO:0004175	endopeptidase activity	Losses
DMELA	GO:0004519	endonuclease activity	Losses
DMELA	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
DMELA	GO:0046872	metal ion binding	Losses
DMELA	GO:0043169	cation binding	Losses
DMELA	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
DMELA	GO:0004984	olfactory receptor activity	Losses
DMELA	GO:0004180	carboxypeptidase activity	Losses
DMELA	GO:0030145	manganese ion binding	Losses
DMELA	GO:0043015	gamma-tubulin binding	Losses
DMELA	GO:0004521	endoribonuclease activity	Losses
DMELA	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
DMELA	GO:0004518	nuclease activity	Losses
DMELA	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
DMELA	GO:0016787	hydrolase activity	Losses
DMELA	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
DMELA	GO:0008241	peptidyl-dipeptidase activity	Losses
DMELA	GO:0004803	transposase activity	Losses
DMELA	GO:0030060	L-malate dehydrogenase activity	Losses
DMELA	GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
DMELA	GO:0008238	exopeptidase activity	Losses
DMELA	GO:0015322	secondary active oligopeptide transmembrane transporter activity	Losses
DMELA	GO:0008774	acetaldehyde dehydrogenase (acetylating) activity	Losses
DMELA	GO:0047886	farnesol dehydrogenase activity	Losses
DMELA	GO:0016019	peptidoglycan receptor activity	Losses
DMELA	GO:0071861	tachykinin receptor binding	Losses
DMELA	GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Losses
DMELA	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
DMELA	GO:0052692	raffinose alpha-galactosidase activity	Losses
DMELA	GO:0050038	L-xylulose reductase (NADP+) activity	Losses
DMELA	GO:0000257	nitrilase activity	Losses
DMELA	GO:0001758	retinal dehydrogenase activity	Losses
DMELA	GO:0004567	beta-mannosidase activity	Losses
DMELA	GO:0004557	alpha-galactosidase activity	Losses
DMELA	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
DMELA	GO:0032500	muramyl dipeptide binding	Losses
DMELA	GO:0001875	lipopolysaccharide receptor activity	Losses
DMELA	GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity	Losses
DMELA	GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Losses
DMELA	GO:0017128	phospholipid scramblase activity	Losses
DMELA	GO:0008456	alpha-N-acetylgalactosaminidase activity	Losses
DMELA	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity	Losses
DMELA	GO:0004540	ribonuclease activity	Losses
DMELA	GO:0030246	carbohydrate binding	Losses
DMELA	GO:0003723	RNA binding	Losses
DMELA	GO:0043167	ion binding	Losses
DMELA	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DMELA	GO:0034061	DNA polymerase activity	Extinctions
DMELA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
DMELA	GO:0070001	aspartic-type peptidase activity	Extinctions
DMELA	GO:0140097	catalytic activity, acting on DNA	Extinctions
DMELA	GO:0016779	nucleotidyltransferase activity	Extinctions
DMELA	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
DMELA	GO:0008270	zinc ion binding	Extinctions
DMELA	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
DMELA	GO:0046914	transition metal ion binding	Extinctions
DMELA	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
DMELA	GO:0004175	endopeptidase activity	Extinctions
DMELA	GO:0004521	endoribonuclease activity	Extinctions
DMELA	GO:0046872	metal ion binding	Extinctions
DMELA	GO:0043169	cation binding	Extinctions
DMELA	GO:0008233	peptidase activity	Extinctions
DMELA	GO:0030060	L-malate dehydrogenase activity	Extinctions
DMELA	GO:0004540	ribonuclease activity	Extinctions
DMELA	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
DMELA	GO:0016615	malate dehydrogenase activity	Extinctions
DMELA	GO:0004842	ubiquitin-protein transferase activity	Extinctions
DMELA	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
DMELA	GO:0003676	nucleic acid binding	Extinctions
DMELA	GO:0016772	transferase activity, transferring phosphorus-containing groups	Extinctions
DMELA	GO:0003723	RNA binding	Extinctions
DMELA	GO:0004519	endonuclease activity	Extinctions
DMELA	GO:0004984	olfactory receptor activity	Extinctions
DMELA	GO:0034235	GPI anchor binding	Extinctions
DMELA	GO:0003883	CTP synthase activity	Extinctions
DMELA	GO:0003677	DNA binding	Extinctions
DMELA	GO:0004518	nuclease activity	Extinctions
DMELA	GO:0050824	water binding	Extinctions
DMELA	GO:0050825	ice binding	Extinctions
HY35	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY35	GO:0034061	DNA polymerase activity	Gains
HY35	GO:0070001	aspartic-type peptidase activity	Gains
HY35	GO:0004190	aspartic-type endopeptidase activity	Gains
HY35	GO:0016779	nucleotidyltransferase activity	Gains
HY35	GO:0140097	catalytic activity, acting on DNA	Gains
HY35	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
HY35	GO:0004519	endonuclease activity	Gains
HY35	GO:0015078	hydrogen ion transmembrane transporter activity	Gains
HY35	GO:0099600	transmembrane receptor activity	Gains
HY35	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY35	GO:0004888	transmembrane signaling receptor activity	Gains
HY35	GO:0004518	nuclease activity	Gains
HY35	GO:0022891	substrate-specific transmembrane transporter activity	Gains
HY35	GO:0015075	ion transmembrane transporter activity	Gains
HY35	GO:0022857	transmembrane transporter activity	Gains
HY35	GO:0004984	olfactory receptor activity	Gains
HY35	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
HY35	GO:0038023	signaling receptor activity	Gains
HY35	GO:0003990	acetylcholinesterase activity	Gains
HY35	GO:0004104	cholinesterase activity	Gains
HY35	GO:0016801	hydrolase activity, acting on ether bonds	Gains
HY35	GO:0022892	substrate-specific transporter activity	Gains
HY35	GO:0099094	ligand-gated cation channel activity	Gains
HY35	GO:0004872	receptor activity	Gains
HY35	GO:0008270	zinc ion binding	Gains
HY35	GO:0015276	ligand-gated ion channel activity	Gains
HY35	GO:0022834	ligand-gated channel activity	Gains
HY35	GO:0022890	inorganic cation transmembrane transporter activity	Gains
HY35	GO:0005549	odorant binding	Gains
HY35	GO:0009055	electron transfer activity	Gains
HY35	GO:0015605	organophosphate ester transmembrane transporter activity	Gains
HY35	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY35	GO:0060089	molecular transducer activity	Gains
HY35	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
HY35	GO:0033867	Fas-activated serine/threonine kinase activity	Gains
HY35	GO:0015277	kainate selective glutamate receptor activity	Gains
HY35	GO:0004846	urate oxidase activity	Gains
HY35	GO:0015217	ADP transmembrane transporter activity	Gains
HY35	GO:0004556	alpha-amylase activity	Gains
HY35	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
HY35	GO:0052870	tocopherol omega-hydroxylase activity	Gains
HY35	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
HY35	GO:0051011	microtubule minus-end binding	Gains
HY35	GO:0008940	nitrate reductase activity	Gains
HY35	GO:0016160	amylase activity	Gains
HY35	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY35	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY35	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
HY35	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY35	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
HY35	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
HY35	GO:0033971	hydroxyisourate hydrolase activity	Gains
HY35	GO:0005347	ATP transmembrane transporter activity	Gains
HY35	GO:0005471	ATP:ADP antiporter activity	Gains
HY35	GO:0042736	NADH kinase activity	Gains
HY35	GO:0009703	nitrate reductase (NADH) activity	Gains
HY35	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY35	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
HY35	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
HY35	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY35	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
HY35	GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Gains
HY35	GO:0005219	ryanodine-sensitive calcium-release channel activity	Gains
HY35	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
HY35	GO:0004153	dihydropterin deaminase activity	Gains
HY35	GO:0047536	2-aminoadipate transaminase activity	Gains
HY35	GO:0050111	mycocerosate synthase activity	Gains
HY35	GO:0046914	transition metal ion binding	Gains
HY35	GO:0004930	G-protein coupled receptor activity	Gains
HY35	GO:0008324	cation transmembrane transporter activity	Gains
HY35	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
HY35	GO:0019239	deaminase activity	Gains
HY35	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY35	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
HY35	GO:0008233	peptidase activity	Gains
HY35	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY35	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY35	GO:0015002	heme-copper terminal oxidase activity	Gains
HY35	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
HY35	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
HY35	GO:0004129	cytochrome-c oxidase activity	Gains
HY35	GO:0004521	endoribonuclease activity	Gains
HY35	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Gains
HY35	GO:0015215	nucleotide transmembrane transporter activity	Gains
HY35	GO:0015216	purine nucleotide transmembrane transporter activity	Gains
HY35	GO:0000295	adenine nucleotide transmembrane transporter activity	Gains
HY35	GO:0016420	malonyltransferase activity	Gains
HY35	GO:0016419	S-malonyltransferase activity	Gains
HY35	GO:0018685	alkane 1-monooxygenase activity	Gains
HY35	GO:0033041	sweet taste receptor activity	Gains
HY35	GO:0005346	purine ribonucleotide transmembrane transporter activity	Gains
HY35	GO:0008140	cAMP response element binding protein binding	Gains
HY35	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Gains
HY35	GO:0004496	mevalonate kinase activity	Gains
HY35	GO:0008892	guanine deaminase activity	Gains
HY35	GO:0015301	anion:anion antiporter activity	Gains
HY35	GO:0004871	signal transducer activity	Gains
HY35	GO:0005215	transporter activity	Gains
HY35	GO:0005230	extracellular ligand-gated ion channel activity	Gains
HY35	GO:0046872	metal ion binding	Gains
HY35	GO:0004175	endopeptidase activity	Gains
HY35	GO:0043169	cation binding	Gains
HY35	GO:0015439	heme-transporting ATPase activity	Gains
HY35	GO:0015278	calcium-release channel activity	Gains
HY35	GO:0016418	S-acetyltransferase activity	Gains
HY35	GO:0048027	mRNA 5'-UTR binding	Gains
HY35	GO:0004013	adenosylhomocysteinase activity	Gains
HY35	GO:0043394	proteoglycan binding	Gains
HY35	GO:0043395	heparan sulfate proteoglycan binding	Gains
HY35	GO:0016802	trialkylsulfonium hydrolase activity	Gains
HY35	GO:0004463	leukotriene-A4 hydrolase activity	Gains
HY35	GO:0099604	ligand-gated calcium channel activity	Gains
HY35	GO:0004185	serine-type carboxypeptidase activity	Gains
HY35	GO:0003723	RNA binding	Gains
HY35	GO:0022836	gated channel activity	Gains
HY35	GO:0060089	molecular transducer activity	Losses
HY35	GO:0004872	receptor activity	Losses
HY35	GO:0099600	transmembrane receptor activity	Losses
HY35	GO:0038023	signaling receptor activity	Losses
HY35	GO:0004984	olfactory receptor activity	Losses
HY35	GO:0004888	transmembrane signaling receptor activity	Losses
HY35	GO:0004930	G-protein coupled receptor activity	Losses
HY35	GO:0016408	C-acyltransferase activity	Losses
HY35	GO:0005549	odorant binding	Losses
HY35	GO:0004758	serine C-palmitoyltransferase activity	Losses
HY35	GO:0016454	C-palmitoyltransferase activity	Losses
HY35	GO:0004871	signal transducer activity	Losses
HY35	GO:0004312	fatty acid synthase activity	Losses
HY35	GO:0016805	dipeptidase activity	Losses
HY35	GO:0008239	dipeptidyl-peptidase activity	Losses
HY35	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
HY35	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
HY35	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
HY35	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	Losses
HY35	GO:0016933	extracellularly glycine-gated ion channel activity	Losses
HY35	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Losses
HY35	GO:0032093	SAM domain binding	Losses
HY35	GO:0036401	pyrokinin receptor activity	Losses
HY35	GO:0004689	phosphorylase kinase activity	Losses
HY35	GO:0004634	phosphopyruvate hydratase activity	Losses
HY35	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Losses
HY35	GO:0008336	gamma-butyrobetaine dioxygenase activity	Losses
HY35	GO:0060308	GTP cyclohydrolase I regulator activity	Losses
HY35	GO:0050353	trimethyllysine dioxygenase activity	Losses
HY35	GO:0004321	fatty-acyl-CoA synthase activity	Losses
HY35	GO:0047886	farnesol dehydrogenase activity	Losses
HY35	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
HY35	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
HY35	GO:0005215	transporter activity	Losses
HY35	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
HY35	GO:0008238	exopeptidase activity	Losses
HY35	GO:0004890	GABA-A receptor activity	Losses
HY35	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Losses
HY35	GO:0003933	GTP cyclohydrolase activity	Losses
HY35	GO:0003934	GTP cyclohydrolase I activity	Losses
HY35	GO:0004657	proline dehydrogenase activity	Losses
HY35	GO:0008967	phosphoglycolate phosphatase activity	Losses
HY35	GO:0001607	neuromedin U receptor activity	Losses
HY35	GO:0005483	soluble NSF attachment protein activity	Losses
HY35	GO:0030553	cGMP binding	Losses
HY35	GO:0004370	glycerol kinase activity	Losses
HY35	GO:0009882	blue light photoreceptor activity	Losses
HY35	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Losses
HY35	GO:0004470	malic enzyme activity	Losses
HY35	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Losses
HY35	GO:0003858	3-hydroxybutyrate dehydrogenase activity	Losses
HY35	GO:0030246	carbohydrate binding	Losses
HY35	GO:0004984	olfactory receptor activity	Extinctions
HY35	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
HY35	GO:0005549	odorant binding	Extinctions
HY35	GO:0060308	GTP cyclohydrolase I regulator activity	Extinctions
HY35	GO:0004872	receptor activity	Extinctions
HY35	GO:0060089	molecular transducer activity	Extinctions
HY35	GO:0003933	GTP cyclohydrolase activity	Extinctions
HY35	GO:0003934	GTP cyclohydrolase I activity	Extinctions
HY35	GO:0004657	proline dehydrogenase activity	Extinctions
HY35	GO:0008967	phosphoglycolate phosphatase activity	Extinctions
HY35	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	Extinctions
HY35	GO:0099600	transmembrane receptor activity	Extinctions
HY35	GO:0008375	acetylglucosaminyltransferase activity	Extinctions
HY35	GO:0004758	serine C-palmitoyltransferase activity	Extinctions
HY35	GO:0016454	C-palmitoyltransferase activity	Extinctions
HY35	GO:0051920	peroxiredoxin activity	Extinctions
HY35	GO:0017108	5'-flap endonuclease activity	Extinctions
HY35	GO:0019238	cyclohydrolase activity	Extinctions
HY37	GO:0038023	signaling receptor activity	Gains
HY37	GO:0099600	transmembrane receptor activity	Gains
HY37	GO:0004888	transmembrane signaling receptor activity	Gains
HY37	GO:0004872	receptor activity	Gains
HY37	GO:0060089	molecular transducer activity	Gains
HY37	GO:0005549	odorant binding	Gains
HY37	GO:0004871	signal transducer activity	Gains
HY37	GO:0004984	olfactory receptor activity	Gains
HY37	GO:0004930	G-protein coupled receptor activity	Gains
HY37	GO:0070001	aspartic-type peptidase activity	Gains
HY37	GO:0004190	aspartic-type endopeptidase activity	Gains
HY37	GO:0022836	gated channel activity	Gains
HY37	GO:0008307	structural constituent of muscle	Gains
HY37	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HY37	GO:0070330	aromatase activity	Gains
HY37	GO:0015079	potassium ion transmembrane transporter activity	Gains
HY37	GO:0018685	alkane 1-monooxygenase activity	Gains
HY37	GO:0005267	potassium channel activity	Gains
HY37	GO:0003707	steroid hormone receptor activity	Gains
HY37	GO:0005201	extracellular matrix structural constituent	Gains
HY37	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY37	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
HY37	GO:0022843	voltage-gated cation channel activity	Gains
HY37	GO:0005249	voltage-gated potassium channel activity	Gains
HY37	GO:0022834	ligand-gated channel activity	Gains
HY37	GO:0015276	ligand-gated ion channel activity	Gains
HY37	GO:0005216	ion channel activity	Gains
HY37	GO:0022838	substrate-specific channel activity	Gains
HY37	GO:0022803	passive transmembrane transporter activity	Gains
HY37	GO:0015267	channel activity	Gains
HY37	GO:0009055	electron transfer activity	Gains
HY37	GO:0043169	cation binding	Gains
HY37	GO:0005230	extracellular ligand-gated ion channel activity	Gains
HY37	GO:0015269	calcium-activated potassium channel activity	Gains
HY37	GO:0030594	neurotransmitter receptor activity	Gains
HY37	GO:0022832	voltage-gated channel activity	Gains
HY37	GO:0005244	voltage-gated ion channel activity	Gains
HY37	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
HY37	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
HY37	GO:0005227	calcium activated cation channel activity	Gains
HY37	GO:0004104	cholinesterase activity	Gains
HY37	GO:0003990	acetylcholinesterase activity	Gains
HY37	GO:0003960	NADPH:quinone reductase activity	Gains
HY37	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Gains
HY37	GO:0005261	cation channel activity	Gains
HY37	GO:0004970	ionotropic glutamate receptor activity	Gains
HY37	GO:0022824	transmitter-gated ion channel activity	Gains
HY37	GO:0022835	transmitter-gated channel activity	Gains
HY37	GO:0046872	metal ion binding	Gains
HY37	GO:0003676	nucleic acid binding	Gains
HY37	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
HY37	GO:0003774	motor activity	Gains
HY37	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
HY37	GO:0004993	G-protein coupled serotonin receptor activity	Gains
HY37	GO:0099589	serotonin receptor activity	Gains
HY37	GO:0022839	ion gated channel activity	Gains
HY37	GO:0008527	taste receptor activity	Gains
HY37	GO:0032027	myosin light chain binding	Gains
HY37	GO:0034061	DNA polymerase activity	Gains
HY37	GO:0008270	zinc ion binding	Gains
HY37	GO:0008066	glutamate receptor activity	Gains
HY37	GO:0046914	transition metal ion binding	Gains
HY37	GO:0060072	large conductance calcium-activated potassium channel activity	Gains
HY37	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Gains
HY37	GO:0070976	TIR domain binding	Gains
HY37	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
HY37	GO:0004995	tachykinin receptor activity	Gains
HY37	GO:0035049	juvenile hormone acid methyltransferase activity	Gains
HY37	GO:0004971	AMPA glutamate receptor activity	Gains
HY37	GO:0016841	ammonia-lyase activity	Gains
HY37	GO:0015026	coreceptor activity	Gains
HY37	GO:0043425	bHLH transcription factor binding	Gains
HY37	GO:0004398	histidine decarboxylase activity	Gains
HY37	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY37	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
HY37	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
HY37	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY37	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
HY37	GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
HY37	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
HY37	GO:0019113	limonene monooxygenase activity	Gains
HY37	GO:0005221	intracellular cyclic nucleotide activated cation channel activity	Gains
HY37	GO:0005222	intracellular cAMP activated cation channel activity	Gains
HY37	GO:0005223	intracellular cGMP activated cation channel activity	Gains
HY37	GO:0008780	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	Gains
HY37	GO:0008747	N-acetylneuraminate lyase activity	Gains
HY37	GO:0050111	mycocerosate synthase activity	Gains
HY37	GO:0008801	beta-phosphoglucomutase activity	Gains
HY37	GO:0043855	cyclic nucleotide-gated ion channel activity	Gains
HY37	GO:0015151	alpha-glucoside transmembrane transporter activity	Gains
HY37	GO:0061598	molybdopterin adenylyltransferase activity	Gains
HY37	GO:0061599	molybdopterin molybdotransferase activity	Gains
HY37	GO:0004794	L-threonine ammonia-lyase activity	Gains
HY37	GO:0004796	thromboxane-A synthase activity	Gains
HY37	GO:0015142	tricarboxylic acid transmembrane transporter activity	Gains
HY37	GO:0015137	citrate transmembrane transporter activity	Gains
HY37	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	Gains
HY37	GO:0070856	myosin VI light chain binding	Gains
HY37	GO:0015277	kainate selective glutamate receptor activity	Gains
HY37	GO:0042947	glucoside transmembrane transporter activity	Gains
HY37	GO:0016499	orexin receptor activity	Gains
HY37	GO:0004508	steroid 17-alpha-monooxygenase activity	Gains
HY37	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
HY37	GO:0052870	tocopherol omega-hydroxylase activity	Gains
HY37	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
HY37	GO:0004611	phosphoenolpyruvate carboxykinase activity	Gains
HY37	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Gains
HY37	GO:0015574	trehalose transmembrane transporter activity	Gains
HY37	GO:0018676	(S)-limonene 7-monooxygenase activity	Gains
HY37	GO:0019010	farnesoic acid O-methyltransferase activity	Gains
HY37	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY37	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY37	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
HY37	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY37	GO:0016597	amino acid binding	Gains
HY37	GO:0050824	water binding	Losses
HY37	GO:0050825	ice binding	Losses
HY37	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY37	GO:0034061	DNA polymerase activity	Losses
HY37	GO:0070001	aspartic-type peptidase activity	Losses
HY37	GO:0004190	aspartic-type endopeptidase activity	Losses
HY37	GO:0140097	catalytic activity, acting on DNA	Losses
HY37	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Losses
HY37	GO:0004602	glutathione peroxidase activity	Losses
HY37	GO:0016779	nucleotidyltransferase activity	Losses
HY37	GO:0004364	glutathione transferase activity	Losses
HY37	GO:0030145	manganese ion binding	Losses
HY37	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Losses
HY37	GO:0004803	transposase activity	Losses
HY37	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY37	GO:0008237	metallopeptidase activity	Losses
HY37	GO:0008422	beta-glucosidase activity	Losses
HY37	GO:0004324	ferredoxin-NADP+ reductase activity	Losses
HY37	GO:0004170	dUTP diphosphatase activity	Losses
HY37	GO:0035198	miRNA binding	Losses
HY37	GO:0030023	extracellular matrix constituent conferring elasticity	Losses
HY37	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
HY37	GO:0070735	protein-glycine ligase activity	Losses
HY37	GO:0070736	protein-glycine ligase activity, initiating	Losses
HY37	GO:0070737	protein-glycine ligase activity, elongating	Losses
HY37	GO:0050232	putrescine oxidase activity	Losses
HY37	GO:0004760	serine-pyruvate transaminase activity	Losses
HY37	GO:0097493	structural molecule activity conferring elasticity	Losses
HY37	GO:0018833	DDT-dehydrochlorinase activity	Losses
HY37	GO:0004667	prostaglandin-D synthase activity	Losses
HY37	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Losses
HY37	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Losses
HY37	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
HY37	GO:0005214	structural constituent of chitin-based cuticle	Losses
HY37	GO:0004175	endopeptidase activity	Losses
HY37	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
HY37	GO:0047429	nucleoside-triphosphate diphosphatase activity	Losses
HY37	GO:0008453	alanine-glyoxylate transaminase activity	Losses
HY37	GO:0016848	carbon-halide lyase activity	Losses
HY37	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
HY37	GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
HY37	GO:0031386	protein tag	Losses
HY37	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	Losses
HY37	GO:0070594	juvenile hormone response element binding	Losses
HY37	GO:0050591	quinine 3-monooxygenase activity	Losses
HY37	GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
HY37	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Losses
HY37	GO:0008233	peptidase activity	Losses
HY37	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Losses
HY37	GO:0004601	peroxidase activity	Losses
HY37	GO:0097747	RNA polymerase activity	Losses
HY37	GO:0034062	5'-3' RNA polymerase activity	Losses
HY37	GO:0004222	metalloendopeptidase activity	Losses
HY37	GO:0046592	polyamine oxidase activity	Losses
HY37	GO:0004368	glycerol-3-phosphate dehydrogenase activity	Losses
HY37	GO:0035197	siRNA binding	Losses
HY37	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	Losses
HY37	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Losses
HY37	GO:0004733	pyridoxamine-phosphate oxidase activity	Losses
HY37	GO:0003963	RNA-3'-phosphate cyclase activity	Losses
HY37	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	Losses
HY37	GO:0052739	phosphatidylserine 1-acylhydrolase activity	Losses
HY37	GO:0010340	carboxyl-O-methyltransferase activity	Losses
HY37	GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Losses
HY37	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	Losses
HY37	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	Losses
HY37	GO:0051998	protein carboxyl O-methyltransferase activity	Losses
HY37	GO:0004170	dUTP diphosphatase activity	Extinctions
HY37	GO:0004760	serine-pyruvate transaminase activity	Extinctions
HY37	GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
HY37	GO:0008453	alanine-glyoxylate transaminase activity	Extinctions
HY37	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Extinctions
HY37	GO:0070594	juvenile hormone response element binding	Extinctions
HY37	GO:0050824	water binding	Extinctions
HY37	GO:0050825	ice binding	Extinctions
HY37	GO:0004649	poly(ADP-ribose) glycohydrolase activity	Extinctions
HY37	GO:0004733	pyridoxamine-phosphate oxidase activity	Extinctions
HY37	GO:0005527	macrolide binding	Extinctions
HY37	GO:0005528	FK506 binding	Extinctions
HY37	GO:0004344	glucose dehydrogenase activity	Extinctions
HY37	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Extinctions
HY37	GO:0015020	glucuronosyltransferase activity	Extinctions
HY37	GO:0008812	choline dehydrogenase activity	Extinctions
HY37	GO:0048037	cofactor binding	Extinctions
HY37	GO:0030145	manganese ion binding	Extinctions
HY31	GO:0003676	nucleic acid binding	Gains
HY31	GO:0008527	taste receptor activity	Gains
HY31	GO:0070001	aspartic-type peptidase activity	Gains
HY31	GO:0004190	aspartic-type endopeptidase activity	Gains
HY31	GO:1901363	heterocyclic compound binding	Gains
HY31	GO:0097159	organic cyclic compound binding	Gains
HY31	GO:0008270	zinc ion binding	Gains
HY31	GO:0004175	endopeptidase activity	Gains
HY31	GO:0005549	odorant binding	Gains
HY31	GO:0005488	binding	Gains
HY31	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY31	GO:0008233	peptidase activity	Gains
HY31	GO:0004984	olfactory receptor activity	Gains
HY31	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY31	GO:0034061	DNA polymerase activity	Gains
HY31	GO:0046914	transition metal ion binding	Gains
HY31	GO:0050780	dopamine receptor binding	Gains
HY31	GO:0036132	13-prostaglandin reductase activity	Gains
HY31	GO:0031752	D5 dopamine receptor binding	Gains
HY31	GO:0043993	histone acetyltransferase activity (H3-K18 specific)	Gains
HY31	GO:0008349	MAP kinase kinase kinase kinase activity	Gains
HY31	GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	Gains
HY31	GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	Gains
HY31	GO:0044017	histone acetyltransferase activity (H3-K27 specific)	Gains
HY31	GO:0004324	ferredoxin-NADP+ reductase activity	Gains
HY31	GO:0030628	pre-mRNA 3'-splice site binding	Gains
HY31	GO:0002094	polyprenyltransferase activity	Gains
HY31	GO:0031005	filamin binding	Gains
HY31	GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	Gains
HY31	GO:0042656	JUN kinase kinase kinase kinase activity	Gains
HY31	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
HY31	GO:0004168	dolichol kinase activity	Gains
HY31	GO:0015459	potassium channel regulator activity	Gains
HY31	GO:0004711	ribosomal protein S6 kinase activity	Gains
HY31	GO:0004852	uroporphyrinogen-III synthase activity	Gains
HY31	GO:0004823	leucine-tRNA ligase activity	Gains
HY31	GO:0004046	aminoacylase activity	Gains
HY31	GO:0016843	amine-lyase activity	Gains
HY31	GO:0016844	strictosidine synthase activity	Gains
HY31	GO:0008140	cAMP response element binding protein binding	Gains
HY31	GO:0003682	chromatin binding	Gains
HY31	GO:0140097	catalytic activity, acting on DNA	Gains
HY31	GO:0004872	receptor activity	Gains
HY31	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY31	GO:0008527	taste receptor activity	Losses
HY31	GO:0016801	hydrolase activity, acting on ether bonds	Losses
HY31	GO:0008329	signaling pattern recognition receptor activity	Losses
HY31	GO:0004463	leukotriene-A4 hydrolase activity	Losses
HY31	GO:0038187	pattern recognition receptor activity	Losses
HY31	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
HY31	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
HY31	GO:0008081	phosphoric diester hydrolase activity	Losses
HY31	GO:0009055	electron transfer activity	Losses
HY31	GO:0004312	fatty acid synthase activity	Losses
HY31	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY31	GO:0016803	ether hydrolase activity	Losses
HY31	GO:0042834	peptidoglycan binding	Losses
HY31	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
HY31	GO:0020037	heme binding	Losses
HY31	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
HY31	GO:0046906	tetrapyrrole binding	Losses
HY31	GO:0016298	lipase activity	Losses
HY31	GO:0003990	acetylcholinesterase activity	Losses
HY31	GO:0008812	choline dehydrogenase activity	Losses
HY31	GO:0004104	cholinesterase activity	Losses
HY31	GO:0015002	heme-copper terminal oxidase activity	Losses
HY31	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
HY31	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
HY31	GO:0004129	cytochrome-c oxidase activity	Losses
HY31	GO:0004620	phospholipase activity	Losses
HY31	GO:0038023	signaling receptor activity	Losses
HY31	GO:0004576	oligosaccharyl transferase activity	Losses
HY31	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Losses
HY31	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
HY31	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
HY31	GO:0099600	transmembrane receptor activity	Losses
HY31	GO:0008238	exopeptidase activity	Losses
HY31	GO:0060089	molecular transducer activity	Losses
HY31	GO:0004888	transmembrane signaling receptor activity	Losses
HY31	GO:0004872	receptor activity	Losses
HY31	GO:0016019	peptidoglycan receptor activity	Losses
HY31	GO:0015250	water channel activity	Losses
HY31	GO:0015217	ADP transmembrane transporter activity	Losses
HY31	GO:0030366	molybdopterin synthase activity	Losses
HY31	GO:0001875	lipopolysaccharide receptor activity	Losses
HY31	GO:0008020	G-protein coupled photoreceptor activity	Losses
HY31	GO:0003919	FMN adenylyltransferase activity	Losses
HY31	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
HY31	GO:0004507	steroid 11-beta-monooxygenase activity	Losses
HY31	GO:0003933	GTP cyclohydrolase activity	Losses
HY31	GO:0003934	GTP cyclohydrolase I activity	Losses
HY31	GO:0052869	arachidonic acid omega-hydroxylase activity	Losses
HY31	GO:0052870	tocopherol omega-hydroxylase activity	Losses
HY31	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Losses
HY31	GO:0072542	protein phosphatase activator activity	Losses
HY31	GO:0051011	microtubule minus-end binding	Losses
HY31	GO:0008940	nitrate reductase activity	Losses
HY31	GO:0004604	phosphoadenylyl-sulfate reductase (thioredoxin) activity	Losses
HY31	GO:0046790	virion binding	Losses
HY31	GO:0019010	farnesoic acid O-methyltransferase activity	Losses
HY31	GO:0034584	piRNA binding	Losses
HY31	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
HY31	GO:0050051	leukotriene-B4 20-monooxygenase activity	Losses
HY31	GO:0004062	aryl sulfotransferase activity	Losses
HY31	GO:0004027	alcohol sulfotransferase activity	Losses
HY31	GO:0004034	aldose 1-epimerase activity	Losses
HY31	GO:0016794	diphosphoric monoester hydrolase activity	Losses
HY31	GO:0005372	water transmembrane transporter activity	Losses
HY31	GO:0035049	juvenile hormone acid methyltransferase activity	Losses
HY31	GO:0005347	ATP transmembrane transporter activity	Losses
HY31	GO:0008160	protein tyrosine phosphatase activator activity	Losses
HY31	GO:0005471	ATP:ADP antiporter activity	Losses
HY31	GO:0042736	NADH kinase activity	Losses
HY31	GO:0009703	nitrate reductase (NADH) activity	Losses
HY31	GO:0047749	cholestanetriol 26-monooxygenase activity	Losses
HY31	GO:0004304	estrone sulfotransferase activity	Losses
HY31	GO:0004490	methylglutaconyl-CoA hydratase activity	Losses
HY31	GO:0047886	farnesol dehydrogenase activity	Losses
HY31	GO:0008728	GTP diphosphokinase activity	Losses
HY31	GO:0071885	N-terminal protein N-methyltransferase activity	Losses
HY31	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Losses
HY31	GO:0032500	muramyl dipeptide binding	Losses
HY31	GO:0004153	dihydropterin deaminase activity	Losses
HY31	GO:0047536	2-aminoadipate transaminase activity	Losses
HY31	GO:0051721	protein phosphatase 2A binding	Losses
HY31	GO:0004139	deoxyribose-phosphate aldolase activity	Losses
HY31	GO:0019211	phosphatase activator activity	Losses
HY31	GO:0016491	oxidoreductase activity	Losses
HY31	GO:0034061	DNA polymerase activity	Losses
HY31	GO:0005198	structural molecule activity	Losses
HY31	GO:0004180	carboxypeptidase activity	Losses
HY31	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
HY31	GO:0015605	organophosphate ester transmembrane transporter activity	Losses
HY31	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Losses
HY31	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
HY31	GO:0004497	monooxygenase activity	Losses
HY31	GO:0004930	G-protein coupled receptor activity	Losses
HY31	GO:0008812	choline dehydrogenase activity	Extinctions
HY31	GO:0008527	taste receptor activity	Extinctions
HY31	GO:0004576	oligosaccharyl transferase activity	Extinctions
HY31	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Extinctions
HY31	GO:0016801	hydrolase activity, acting on ether bonds	Extinctions
HY31	GO:0005198	structural molecule activity	Extinctions
HY31	GO:0030366	molybdopterin synthase activity	Extinctions
HY31	GO:0004507	steroid 11-beta-monooxygenase activity	Extinctions
HY31	GO:0003933	GTP cyclohydrolase activity	Extinctions
HY31	GO:0003934	GTP cyclohydrolase I activity	Extinctions
HY31	GO:0072542	protein phosphatase activator activity	Extinctions
HY31	GO:0016794	diphosphoric monoester hydrolase activity	Extinctions
HY31	GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
HY31	GO:0047749	cholestanetriol 26-monooxygenase activity	Extinctions
HY31	GO:0008728	GTP diphosphokinase activity	Extinctions
HY31	GO:0071885	N-terminal protein N-methyltransferase activity	Extinctions
HY31	GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Extinctions
HY31	GO:0051721	protein phosphatase 2A binding	Extinctions
HY31	GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
HY31	GO:0019211	phosphatase activator activity	Extinctions
HY31	GO:0004984	olfactory receptor activity	Extinctions
HY31	GO:0008890	glycine C-acetyltransferase activity	Extinctions
HY31	GO:0005549	odorant binding	Extinctions
HY31	GO:0070891	lipoteichoic acid binding	Extinctions
HY31	GO:0035299	inositol pentakisphosphate 2-kinase activity	Extinctions
HY31	GO:0016453	C-acetyltransferase activity	Extinctions
HY31	GO:0001530	lipopolysaccharide binding	Extinctions
HY31	GO:0004090	carbonyl reductase (NADPH) activity	Extinctions
HY31	GO:0004013	adenosylhomocysteinase activity	Extinctions
HY31	GO:0030882	lipid antigen binding	Extinctions
HY31	GO:0016802	trialkylsulfonium hydrolase activity	Extinctions
HY31	GO:0004462	lactoylglutathione lyase activity	Extinctions
HY31	GO:0004463	leukotriene-A4 hydrolase activity	Extinctions
HY31	GO:0071855	neuropeptide receptor binding	Extinctions
HY31	GO:0019238	cyclohydrolase activity	Extinctions
HY31	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
HY31	GO:0016859	cis-trans isomerase activity	Extinctions
HY31	GO:0003823	antigen binding	Extinctions
HY31	GO:0003735	structural constituent of ribosome	Extinctions
CCINC	GO:0004984	olfactory receptor activity	Gains
CCINC	GO:0005549	odorant binding	Gains
CCINC	GO:0140097	catalytic activity, acting on DNA	Gains
CCINC	GO:0070001	aspartic-type peptidase activity	Gains
CCINC	GO:0004190	aspartic-type endopeptidase activity	Gains
CCINC	GO:0004872	receptor activity	Gains
CCINC	GO:0004888	transmembrane signaling receptor activity	Gains
CCINC	GO:0008527	taste receptor activity	Gains
CCINC	GO:0003964	RNA-directed DNA polymerase activity	Gains
CCINC	GO:0099600	transmembrane receptor activity	Gains
CCINC	GO:0060089	molecular transducer activity	Gains
CCINC	GO:0038023	signaling receptor activity	Gains
CCINC	GO:0004930	G-protein coupled receptor activity	Gains
CCINC	GO:0034061	DNA polymerase activity	Gains
CCINC	GO:0004519	endonuclease activity	Gains
CCINC	GO:0004871	signal transducer activity	Gains
CCINC	GO:0016841	ammonia-lyase activity	Gains
CCINC	GO:0005212	structural constituent of eye lens	Gains
CCINC	GO:0004518	nuclease activity	Gains
CCINC	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
CCINC	GO:1901363	heterocyclic compound binding	Gains
CCINC	GO:0005044	scavenger receptor activity	Gains
CCINC	GO:0097159	organic cyclic compound binding	Gains
CCINC	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
CCINC	GO:0016779	nucleotidyltransferase activity	Gains
CCINC	GO:0038024	cargo receptor activity	Gains
CCINC	GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
CCINC	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
CCINC	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
CCINC	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
CCINC	GO:0016783	sulfurtransferase activity	Gains
CCINC	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Gains
CCINC	GO:0003676	nucleic acid binding	Gains
CCINC	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
CCINC	GO:0004520	endodeoxyribonuclease activity	Gains
CCINC	GO:0016462	pyrophosphatase activity	Gains
CCINC	GO:0017111	nucleoside-triphosphatase activity	Gains
CCINC	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
CCINC	GO:0016787	hydrolase activity	Gains
CCINC	GO:0019239	deaminase activity	Gains
CCINC	GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
CCINC	GO:0005215	transporter activity	Gains
CCINC	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
CCINC	GO:0016776	phosphotransferase activity, phosphate group as acceptor	Gains
CCINC	GO:0004970	ionotropic glutamate receptor activity	Gains
CCINC	GO:0022824	transmitter-gated ion channel activity	Gains
CCINC	GO:0022835	transmitter-gated channel activity	Gains
CCINC	GO:0019201	nucleotide kinase activity	Gains
CCINC	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
CCINC	GO:0004386	helicase activity	Gains
CCINC	GO:0008079	translation termination factor activity	Gains
CCINC	GO:0016840	carbon-nitrogen lyase activity	Gains
CCINC	GO:0003747	translation release factor activity	Gains
CCINC	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
CCINC	GO:0008066	glutamate receptor activity	Gains
CCINC	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
CCINC	GO:0016832	aldehyde-lyase activity	Gains
CCINC	GO:0016779	nucleotidyltransferase activity	Losses
CCINC	GO:0003964	RNA-directed DNA polymerase activity	Losses
CCINC	GO:0034061	DNA polymerase activity	Losses
CCINC	GO:0003723	RNA binding	Losses
CCINC	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
CCINC	GO:0140097	catalytic activity, acting on DNA	Losses
CCINC	GO:0097747	RNA polymerase activity	Losses
CCINC	GO:0034062	5'-3' RNA polymerase activity	Losses
CCINC	GO:0140098	catalytic activity, acting on RNA	Losses
CCINC	GO:0004518	nuclease activity	Losses
CCINC	GO:0031420	alkali metal ion binding	Losses
CCINC	GO:0004743	pyruvate kinase activity	Losses
CCINC	GO:0015114	phosphate ion transmembrane transporter activity	Losses
CCINC	GO:0030955	potassium ion binding	Losses
CCINC	GO:1901677	phosphate transmembrane transporter activity	Losses
CCINC	GO:0017150	tRNA dihydrouridine synthase activity	Losses
CCINC	GO:0003735	structural constituent of ribosome	Losses
CCINC	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
CCINC	GO:0004519	endonuclease activity	Losses
CCINC	GO:0050660	flavin adenine dinucleotide binding	Losses
CCINC	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
CCINC	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
CCINC	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Losses
CCINC	GO:0003939	L-iditol 2-dehydrogenase activity	Losses
CCINC	GO:0030620	U2 snRNA binding	Losses
CCINC	GO:0004370	glycerol kinase activity	Losses
CCINC	GO:0043539	protein serine/threonine kinase activator activity	Losses
CCINC	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	Losses
CCINC	GO:0050662	coenzyme binding	Losses
CCINC	GO:0016491	oxidoreductase activity	Losses
CCINC	GO:0003954	NADH dehydrogenase activity	Losses
CCINC	GO:0004521	endoribonuclease activity	Losses
CCINC	GO:0050661	NADP binding	Losses
CCINC	GO:0048037	cofactor binding	Losses
CCINC	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
CCINC	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	Losses
CCINC	GO:0015929	hexosaminidase activity	Losses
CCINC	GO:0016788	hydrolase activity, acting on ester bonds	Losses
CCINC	GO:0140101	catalytic activity, acting on a tRNA	Losses
CCINC	GO:0019238	cyclohydrolase activity	Losses
CCINC	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Losses
CCINC	GO:0004818	glutamate-tRNA ligase activity	Losses
CCINC	GO:0016418	S-acetyltransferase activity	Losses
CCINC	GO:0016406	carnitine O-acyltransferase activity	Losses
CCINC	GO:0030619	U1 snRNA binding	Losses
CCINC	GO:0004462	lactoylglutathione lyase activity	Losses
CCINC	GO:0004781	sulfate adenylyltransferase (ATP) activity	Losses
CCINC	GO:0004779	sulfate adenylyltransferase activity	Losses
CCINC	GO:0003824	catalytic activity	Losses
CCINC	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
CCINC	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
CCINC	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
CCINC	GO:0016836	hydro-lyase activity	Losses
CCINC	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
CCINC	GO:0016835	carbon-oxygen lyase activity	Losses
CCINC	GO:0003723	RNA binding	Extinctions
CCINC	GO:0016779	nucleotidyltransferase activity	Extinctions
CCINC	GO:0034061	DNA polymerase activity	Extinctions
CCINC	GO:0003735	structural constituent of ribosome	Extinctions
CCINC	GO:0031420	alkali metal ion binding	Extinctions
CCINC	GO:0004743	pyruvate kinase activity	Extinctions
CCINC	GO:0030955	potassium ion binding	Extinctions
CCINC	GO:0017150	tRNA dihydrouridine synthase activity	Extinctions
CCINC	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
CCINC	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
CCINC	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
CCINC	GO:0003954	NADH dehydrogenase activity	Extinctions
CCINC	GO:0030620	U2 snRNA binding	Extinctions
CCINC	GO:0043539	protein serine/threonine kinase activator activity	Extinctions
CCINC	GO:0097747	RNA polymerase activity	Extinctions
CCINC	GO:0034062	5'-3' RNA polymerase activity	Extinctions
CCINC	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
CCINC	GO:0140101	catalytic activity, acting on a tRNA	Extinctions
CCINC	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
CCINC	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
CCINC	GO:0004518	nuclease activity	Extinctions
CCINC	GO:0004781	sulfate adenylyltransferase (ATP) activity	Extinctions
CCINC	GO:0004779	sulfate adenylyltransferase activity	Extinctions
CCINC	GO:0140098	catalytic activity, acting on RNA	Extinctions
CCINC	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Extinctions
CCINC	GO:0016406	carnitine O-acyltransferase activity	Extinctions
CCINC	GO:0030619	U1 snRNA binding	Extinctions
CCINC	GO:0004462	lactoylglutathione lyase activity	Extinctions
CCINC	GO:0140097	catalytic activity, acting on DNA	Extinctions
CCINC	GO:0005198	structural molecule activity	Extinctions
CCINC	GO:0019843	rRNA binding	Extinctions
SINVI	GO:0003964	RNA-directed DNA polymerase activity	Gains
SINVI	GO:0034061	DNA polymerase activity	Gains
SINVI	GO:0016779	nucleotidyltransferase activity	Gains
SINVI	GO:0140097	catalytic activity, acting on DNA	Gains
SINVI	GO:0003676	nucleic acid binding	Gains
SINVI	GO:0070001	aspartic-type peptidase activity	Gains
SINVI	GO:0004190	aspartic-type endopeptidase activity	Gains
SINVI	GO:1901363	heterocyclic compound binding	Gains
SINVI	GO:0097159	organic cyclic compound binding	Gains
SINVI	GO:0004519	endonuclease activity	Gains
SINVI	GO:0038023	signaling receptor activity	Gains
SINVI	GO:0004888	transmembrane signaling receptor activity	Gains
SINVI	GO:0004984	olfactory receptor activity	Gains
SINVI	GO:0004518	nuclease activity	Gains
SINVI	GO:0099600	transmembrane receptor activity	Gains
SINVI	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
SINVI	GO:0005549	odorant binding	Gains
SINVI	GO:0004872	receptor activity	Gains
SINVI	GO:0005227	calcium activated cation channel activity	Gains
SINVI	GO:0060089	molecular transducer activity	Gains
SINVI	GO:0019199	transmembrane receptor protein kinase activity	Gains
SINVI	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Gains
SINVI	GO:0022839	ion gated channel activity	Gains
SINVI	GO:0004871	signal transducer activity	Gains
SINVI	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
SINVI	GO:0018685	alkane 1-monooxygenase activity	Gains
SINVI	GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
SINVI	GO:0008270	zinc ion binding	Gains
SINVI	GO:0005488	binding	Gains
SINVI	GO:0046914	transition metal ion binding	Gains
SINVI	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
SINVI	GO:0005509	calcium ion binding	Gains
SINVI	GO:0003677	DNA binding	Gains
SINVI	GO:0015269	calcium-activated potassium channel activity	Gains
SINVI	GO:0070330	aromatase activity	Gains
SINVI	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
SINVI	GO:0004803	transposase activity	Gains
SINVI	GO:0004687	myosin light chain kinase activity	Gains
SINVI	GO:0003960	NADPH:quinone reductase activity	Gains
SINVI	GO:0022836	gated channel activity	Gains
SINVI	GO:0016286	small conductance calcium-activated potassium channel activity	Gains
SINVI	GO:0043015	gamma-tubulin binding	Gains
SINVI	GO:0004175	endopeptidase activity	Gains
SINVI	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
SINVI	GO:0004521	endoribonuclease activity	Gains
SINVI	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
SINVI	GO:0003777	microtubule motor activity	Gains
SINVI	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
SINVI	GO:0004930	G-protein coupled receptor activity	Gains
SINVI	GO:0005201	extracellular matrix structural constituent	Gains
SINVI	GO:0008233	peptidase activity	Gains
SINVI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
SINVI	GO:0003682	chromatin binding	Gains
SINVI	GO:0003735	structural constituent of ribosome	Losses
SINVI	GO:0005198	structural molecule activity	Losses
SINVI	GO:0016491	oxidoreductase activity	Losses
SINVI	GO:0015036	disulfide oxidoreductase activity	Losses
SINVI	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Losses
SINVI	GO:0015035	protein disulfide oxidoreductase activity	Losses
SINVI	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Losses
SINVI	GO:0008900	hydrogen:potassium-exchanging ATPase activity	Losses
SINVI	GO:0001607	neuromedin U receptor activity	Losses
SINVI	GO:0001094	TFIID-class transcription factor binding	Losses
SINVI	GO:0046922	peptide-O-fucosyltransferase activity	Losses
SINVI	GO:0008504	monoamine transmembrane transporter activity	Losses
SINVI	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Losses
SINVI	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Losses
SINVI	GO:0015078	hydrogen ion transmembrane transporter activity	Losses
SINVI	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	Losses
SINVI	GO:0003756	protein disulfide isomerase activity	Losses
SINVI	GO:0032794	GTPase activating protein binding	Losses
SINVI	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Losses
SINVI	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Losses
SINVI	GO:0016744	transferase activity, transferring aldehyde or ketonic groups	Losses
SINVI	GO:0034062	5'-3' RNA polymerase activity	Losses
SINVI	GO:0097747	RNA polymerase activity	Losses
SINVI	GO:1901567	fatty acid derivative binding	Losses
SINVI	GO:0000062	fatty-acyl-CoA binding	Losses
SINVI	GO:0016866	intramolecular transferase activity	Losses
SINVI	GO:0005484	SNAP receptor activity	Losses
SINVI	GO:0140098	catalytic activity, acting on RNA	Losses
SINVI	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
SINVI	GO:0004520	endodeoxyribonuclease activity	Losses
SINVI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
SINVI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Losses
SINVI	GO:0030170	pyridoxal phosphate binding	Losses
SINVI	GO:0050136	NADH dehydrogenase (quinone) activity	Losses
SINVI	GO:0070279	vitamin B6 binding	Losses
SINVI	GO:0003735	structural constituent of ribosome	Extinctions
SINVI	GO:0005198	structural molecule activity	Extinctions
SINVI	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Extinctions
SINVI	GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
SINVI	GO:0008900	hydrogen:potassium-exchanging ATPase activity	Extinctions
SINVI	GO:0001094	TFIID-class transcription factor binding	Extinctions
SINVI	GO:0046922	peptide-O-fucosyltransferase activity	Extinctions
SINVI	GO:0034062	5'-3' RNA polymerase activity	Extinctions
SINVI	GO:0097747	RNA polymerase activity	Extinctions
SINVI	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Extinctions
SINVI	GO:0016866	intramolecular transferase activity	Extinctions
SINVI	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
SINVI	GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
SINVI	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Extinctions
SINVI	GO:0004520	endodeoxyribonuclease activity	Extinctions
SINVI	GO:0140098	catalytic activity, acting on RNA	Extinctions
SINVI	GO:0003954	NADH dehydrogenase activity	Extinctions
SINVI	GO:0004536	deoxyribonuclease activity	Extinctions
SINVI	GO:0019887	protein kinase regulator activity	Extinctions
SINVI	GO:0009982	pseudouridine synthase activity	Extinctions
SINVI	GO:0061659	ubiquitin-like protein ligase activity	Extinctions
SINVI	GO:0061630	ubiquitin protein ligase activity	Extinctions
SINVI	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Extinctions
SINVI	GO:0004045	aminoacyl-tRNA hydrolase activity	Extinctions
SINVI	GO:0034450	ubiquitin-ubiquitin ligase activity	Extinctions
SINVI	GO:0008556	potassium-transporting ATPase activity	Extinctions
SINVI	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
SINVI	GO:0004768	stearoyl-CoA 9-desaturase activity	Extinctions
SINVI	GO:0016215	acyl-CoA desaturase activity	Extinctions
SINVI	GO:0015926	glucosidase activity	Extinctions
SINVI	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
SINVI	GO:0097472	cyclin-dependent protein kinase activity	Extinctions
SINVI	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Extinctions
SINVI	GO:0036442	hydrogen-exporting ATPase activity	Extinctions
SINVI	GO:0030170	pyridoxal phosphate binding	Extinctions
SINVI	GO:0070279	vitamin B6 binding	Extinctions
SINVI	GO:0015002	heme-copper terminal oxidase activity	Extinctions
SINVI	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
SINVI	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
SINVI	GO:0004129	cytochrome-c oxidase activity	Extinctions
HY39	GO:0004984	olfactory receptor activity	Gains
HY39	GO:0005549	odorant binding	Gains
HY39	GO:0099600	transmembrane receptor activity	Gains
HY39	GO:0038023	signaling receptor activity	Gains
HY39	GO:0004888	transmembrane signaling receptor activity	Gains
HY39	GO:0004930	G-protein coupled receptor activity	Gains
HY39	GO:0004872	receptor activity	Gains
HY39	GO:0060089	molecular transducer activity	Gains
HY39	GO:0004871	signal transducer activity	Gains
HY39	GO:0004312	fatty acid synthase activity	Gains
HY39	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
HY39	GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
HY39	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
HY39	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
HY39	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY39	GO:0016630	protochlorophyllide reductase activity	Gains
HY39	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HY39	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Gains
HY39	GO:0005216	ion channel activity	Gains
HY39	GO:0022838	substrate-specific channel activity	Gains
HY39	GO:0022891	substrate-specific transmembrane transporter activity	Gains
HY39	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Gains
HY39	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY39	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY39	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY39	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
HY39	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
HY39	GO:0005329	dopamine transmembrane transporter activity	Gains
HY39	GO:0015098	molybdate ion transmembrane transporter activity	Gains
HY39	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Gains
HY39	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
HY39	GO:0004321	fatty-acyl-CoA synthase activity	Gains
HY39	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
HY39	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Gains
HY39	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
HY39	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
HY39	GO:0050111	mycocerosate synthase activity	Gains
HY39	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
HY39	GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Gains
HY39	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Gains
HY39	GO:0001222	transcription corepressor binding	Gains
HY39	GO:0001226	RNA polymerase II transcription corepressor binding	Gains
HY39	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Gains
HY39	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	Gains
HY39	GO:0016933	extracellularly glycine-gated ion channel activity	Gains
HY39	GO:0015175	neutral amino acid transmembrane transporter activity	Gains
HY39	GO:0019811	cocaine binding	Gains
HY39	GO:0042943	D-amino acid transmembrane transporter activity	Gains
HY39	GO:0015222	serotonin transmembrane transporter activity	Gains
HY39	GO:0036401	pyrokinin receptor activity	Gains
HY39	GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Gains
HY39	GO:0008237	metallopeptidase activity	Gains
HY39	GO:0022803	passive transmembrane transporter activity	Gains
HY39	GO:0015267	channel activity	Gains
HY39	GO:0001012	RNA polymerase II regulatory region DNA binding	Gains
HY39	GO:0016408	C-acyltransferase activity	Gains
HY39	GO:0015075	ion transmembrane transporter activity	Gains
HY39	GO:0005261	cation channel activity	Gains
HY39	GO:0034061	DNA polymerase activity	Gains
HY39	GO:0022857	transmembrane transporter activity	Gains
HY39	GO:0016615	malate dehydrogenase activity	Losses
HY39	GO:0030060	L-malate dehydrogenase activity	Losses
HY39	GO:0004190	aspartic-type endopeptidase activity	Losses
HY39	GO:0070001	aspartic-type peptidase activity	Losses
HY39	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Losses
HY39	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY39	GO:0005272	sodium channel activity	Losses
HY39	GO:0051766	inositol trisphosphate kinase activity	Losses
HY39	GO:0015081	sodium ion transmembrane transporter activity	Losses
HY39	GO:0004104	cholinesterase activity	Losses
HY39	GO:0003990	acetylcholinesterase activity	Losses
HY39	GO:0022857	transmembrane transporter activity	Losses
HY39	GO:0034061	DNA polymerase activity	Losses
HY39	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
HY39	GO:0005215	transporter activity	Losses
HY39	GO:0022892	substrate-specific transporter activity	Losses
HY39	GO:0140097	catalytic activity, acting on DNA	Losses
HY39	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
HY39	GO:0022891	substrate-specific transmembrane transporter activity	Losses
HY39	GO:0042165	neurotransmitter binding	Losses
HY39	GO:0042166	acetylcholine binding	Losses
HY39	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Losses
HY39	GO:0005324	long-chain fatty acid transporter activity	Losses
HY39	GO:0005347	ATP transmembrane transporter activity	Losses
HY39	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Losses
HY39	GO:0005471	ATP:ADP antiporter activity	Losses
HY39	GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	Losses
HY39	GO:0009703	nitrate reductase (NADH) activity	Losses
HY39	GO:0047747	cholate-CoA ligase activity	Losses
HY39	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
HY39	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
HY39	GO:0035368	selenocysteine insertion sequence binding	Losses
HY39	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
HY39	GO:0015217	ADP transmembrane transporter activity	Losses
HY39	GO:0015245	fatty acid transporter activity	Losses
HY39	GO:0008940	nitrate reductase activity	Losses
HY39	GO:0036263	L-DOPA monooxygenase activity	Losses
HY39	GO:0036264	dopamine monooxygenase activity	Losses
HY39	GO:0004097	catechol oxidase activity	Losses
HY39	GO:0004983	neuropeptide Y receptor activity	Losses
HY39	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
HY39	GO:0008514	organic anion transmembrane transporter activity	Losses
HY39	GO:0015075	ion transmembrane transporter activity	Losses
HY39	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
HY39	GO:0015501	glutamate:sodium symporter activity	Losses
HY39	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
HY39	GO:0004033	aldo-keto reductase (NADP) activity	Losses
HY39	GO:0005346	purine ribonucleotide transmembrane transporter activity	Losses
HY39	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
HY39	GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
HY39	GO:0070405	ammonium ion binding	Losses
HY39	GO:0005212	structural constituent of eye lens	Losses
HY39	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Losses
HY39	GO:0015301	anion:anion antiporter activity	Losses
HY39	GO:0004711	ribosomal protein S6 kinase activity	Losses
HY39	GO:0015183	L-aspartate transmembrane transporter activity	Losses
HY39	GO:0050833	pyruvate transmembrane transporter activity	Losses
HY39	GO:0052723	inositol hexakisphosphate 1-kinase activity	Losses
HY39	GO:0052724	inositol hexakisphosphate 3-kinase activity	Losses
HY39	GO:0000295	adenine nucleotide transmembrane transporter activity	Losses
HY39	GO:0015215	nucleotide transmembrane transporter activity	Losses
HY39	GO:0015216	purine nucleotide transmembrane transporter activity	Losses
HY39	GO:0003913	DNA photolyase activity	Losses
HY39	GO:0004503	monophenol monooxygenase activity	Losses
HY39	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Losses
HY39	GO:0017040	ceramidase activity	Losses
HY39	GO:0000828	inositol hexakisphosphate kinase activity	Losses
HY39	GO:0000832	inositol hexakisphosphate 5-kinase activity	Losses
HY39	GO:0015002	heme-copper terminal oxidase activity	Losses
HY39	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
HY39	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
HY39	GO:0004129	cytochrome-c oxidase activity	Losses
HY39	GO:0003700	DNA binding transcription factor activity	Losses
HY39	GO:0003730	mRNA 3'-UTR binding	Losses
HY39	GO:0016779	nucleotidyltransferase activity	Losses
HY39	GO:0048027	mRNA 5'-UTR binding	Losses
HY39	GO:0047429	nucleoside-triphosphate diphosphatase activity	Losses
HY39	GO:0004013	adenosylhomocysteinase activity	Losses
HY39	GO:0008453	alanine-glyoxylate transaminase activity	Losses
HY39	GO:0005416	cation:amino acid symporter activity	Losses
HY39	GO:0051185	coenzyme transporter activity	Losses
HY39	GO:0016802	trialkylsulfonium hydrolase activity	Losses
HY39	GO:0017153	sodium:dicarboxylate symporter activity	Losses
HY39	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Losses
HY39	GO:0005283	sodium:amino acid symporter activity	Losses
HY39	GO:0019107	myristoyltransferase activity	Losses
HY39	GO:0001103	RNA polymerase II repressing transcription factor binding	Losses
HY39	GO:0004813	alanine-tRNA ligase activity	Losses
HY39	GO:0035613	RNA stem-loop binding	Losses
HY39	GO:0004930	G-protein coupled receptor activity	Losses
HY39	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Losses
HY39	GO:0005216	ion channel activity	Losses
HY39	GO:0005272	sodium channel activity	Extinctions
HY39	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Extinctions
HY39	GO:0051766	inositol trisphosphate kinase activity	Extinctions
HY39	GO:0016615	malate dehydrogenase activity	Extinctions
HY39	GO:0004104	cholinesterase activity	Extinctions
HY39	GO:0003990	acetylcholinesterase activity	Extinctions
HY39	GO:0004983	neuropeptide Y receptor activity	Extinctions
HY39	GO:0015081	sodium ion transmembrane transporter activity	Extinctions
HY39	GO:0004930	G-protein coupled receptor activity	Extinctions
HY39	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
HY39	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Extinctions
HY39	GO:0035368	selenocysteine insertion sequence binding	Extinctions
HY39	GO:0015002	heme-copper terminal oxidase activity	Extinctions
HY39	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
HY39	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
HY39	GO:0004129	cytochrome-c oxidase activity	Extinctions
HY39	GO:0052723	inositol hexakisphosphate 1-kinase activity	Extinctions
HY39	GO:0052724	inositol hexakisphosphate 3-kinase activity	Extinctions
HY39	GO:0003913	DNA photolyase activity	Extinctions
HY39	GO:0003904	deoxyribodipyrimidine photo-lyase activity	Extinctions
HY39	GO:0017040	ceramidase activity	Extinctions
HY39	GO:0000828	inositol hexakisphosphate kinase activity	Extinctions
HY39	GO:0000832	inositol hexakisphosphate 5-kinase activity	Extinctions
HY39	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY39	GO:0008188	neuropeptide receptor activity	Extinctions
HY39	GO:0047429	nucleoside-triphosphate diphosphatase activity	Extinctions
HY39	GO:0004013	adenosylhomocysteinase activity	Extinctions
HY39	GO:0008453	alanine-glyoxylate transaminase activity	Extinctions
HY39	GO:0016802	trialkylsulfonium hydrolase activity	Extinctions
HY39	GO:0004813	alanine-tRNA ligase activity	Extinctions
HY39	GO:0035613	RNA stem-loop binding	Extinctions
HY39	GO:0099600	transmembrane receptor activity	Extinctions
HY39	GO:0022857	transmembrane transporter activity	Extinctions
HY39	GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
HY39	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
HY39	GO:0030060	L-malate dehydrogenase activity	Extinctions
HY39	GO:0005216	ion channel activity	Extinctions
HY39	GO:0022838	substrate-specific channel activity	Extinctions
HY39	GO:0038023	signaling receptor activity	Extinctions
HY39	GO:0001653	peptide receptor activity	Extinctions
HY39	GO:0005261	cation channel activity	Extinctions
HY39	GO:0022803	passive transmembrane transporter activity	Extinctions
HY39	GO:0015267	channel activity	Extinctions
HY39	GO:0022891	substrate-specific transmembrane transporter activity	Extinctions
AROSA	GO:0003676	nucleic acid binding	Gains
AROSA	GO:0030414	peptidase inhibitor activity	Gains
AROSA	GO:0005549	odorant binding	Gains
AROSA	GO:0005534	galactose binding	Gains
AROSA	GO:0004064	arylesterase activity	Gains
AROSA	GO:0051015	actin filament binding	Gains
AROSA	GO:0004104	cholinesterase activity	Gains
AROSA	GO:0003990	acetylcholinesterase activity	Gains
AROSA	GO:0004602	glutathione peroxidase activity	Gains
AROSA	GO:0003964	RNA-directed DNA polymerase activity	Gains
AROSA	GO:0016917	GABA receptor activity	Gains
AROSA	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
AROSA	GO:0061134	peptidase regulator activity	Gains
AROSA	GO:0004857	enzyme inhibitor activity	Gains
AROSA	GO:0004803	transposase activity	Gains
AROSA	GO:0032403	protein complex binding	Gains
AROSA	GO:0004190	aspartic-type endopeptidase activity	Losses
AROSA	GO:0070001	aspartic-type peptidase activity	Losses
AROSA	GO:0003964	RNA-directed DNA polymerase activity	Losses
AROSA	GO:0008301	DNA binding, bending	Losses
AROSA	GO:0004300	enoyl-CoA hydratase activity	Losses
AROSA	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Losses
AROSA	GO:0042826	histone deacetylase binding	Losses
AROSA	GO:0004364	glutathione transferase activity	Losses
AROSA	GO:0034061	DNA polymerase activity	Losses
AROSA	GO:0005539	glycosaminoglycan binding	Losses
AROSA	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	Losses
AROSA	GO:0008768	UDP-sugar diphosphatase activity	Losses
AROSA	GO:0015142	tricarboxylic acid transmembrane transporter activity	Losses
AROSA	GO:0015137	citrate transmembrane transporter activity	Losses
AROSA	GO:0015250	water channel activity	Losses
AROSA	GO:0008815	citrate (pro-3S)-lyase activity	Losses
AROSA	GO:0008816	citryl-CoA lyase activity	Losses
AROSA	GO:0008511	sodium:potassium:chloride symporter activity	Losses
AROSA	GO:0018834	dichloromethane dehalogenase activity	Losses
AROSA	GO:0004782	sulfinoalanine decarboxylase activity	Losses
AROSA	GO:0004735	pyrroline-5-carboxylate reductase activity	Losses
AROSA	GO:0005521	lamin binding	Losses
AROSA	GO:0016160	amylase activity	Losses
AROSA	GO:0004556	alpha-amylase activity	Losses
AROSA	GO:0001875	lipopolysaccharide receptor activity	Losses
AROSA	GO:0047874	dolichyldiphosphatase activity	Losses
AROSA	GO:0047598	7-dehydrocholesterol reductase activity	Losses
AROSA	GO:0070576	vitamin D 24-hydroxylase activity	Losses
AROSA	GO:0061598	molybdopterin adenylyltransferase activity	Losses
AROSA	GO:0061599	molybdopterin molybdotransferase activity	Losses
AROSA	GO:0005026	transforming growth factor beta receptor activity, type II	Losses
AROSA	GO:0043715	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity	Losses
AROSA	GO:0043716	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity	Losses
AROSA	GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	Losses
AROSA	GO:0032500	muramyl dipeptide binding	Losses
AROSA	GO:0004068	aspartate 1-decarboxylase activity	Losses
AROSA	GO:0045735	nutrient reservoir activity	Losses
AROSA	GO:0008477	purine nucleosidase activity	Losses
AROSA	GO:0005372	water transmembrane transporter activity	Losses
AROSA	GO:0019182	histamine-gated chloride channel activity	Losses
AROSA	GO:0052716	hydroquinone:oxygen oxidoreductase activity	Losses
AROSA	GO:0004351	glutamate decarboxylase activity	Losses
AROSA	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Losses
AROSA	GO:0004321	fatty-acyl-CoA synthase activity	Losses
AROSA	GO:0050613	delta14-sterol reductase activity	Losses
AROSA	GO:0004332	fructose-bisphosphate aldolase activity	Losses
AROSA	GO:0016018	cyclosporin A binding	Losses
AROSA	GO:0016019	peptidoglycan receptor activity	Losses
AROSA	GO:0034235	GPI anchor binding	Losses
AROSA	GO:0016034	maleylacetoacetate isomerase activity	Losses
AROSA	GO:0008010	structural constituent of chitin-based larval cuticle	Losses
AROSA	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Losses
AROSA	GO:0008301	DNA binding, bending	Extinctions
AROSA	GO:0004300	enoyl-CoA hydratase activity	Extinctions
AROSA	GO:0042826	histone deacetylase binding	Extinctions
AROSA	GO:0004364	glutathione transferase activity	Extinctions
AROSA	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	Extinctions
AROSA	GO:0008768	UDP-sugar diphosphatase activity	Extinctions
AROSA	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
AROSA	GO:0008816	citryl-CoA lyase activity	Extinctions
AROSA	GO:0018834	dichloromethane dehalogenase activity	Extinctions
AROSA	GO:0005521	lamin binding	Extinctions
AROSA	GO:0016160	amylase activity	Extinctions
AROSA	GO:0004556	alpha-amylase activity	Extinctions
AROSA	GO:0047874	dolichyldiphosphatase activity	Extinctions
AROSA	GO:0047598	7-dehydrocholesterol reductase activity	Extinctions
AROSA	GO:0070576	vitamin D 24-hydroxylase activity	Extinctions
AROSA	GO:0061598	molybdopterin adenylyltransferase activity	Extinctions
AROSA	GO:0061599	molybdopterin molybdotransferase activity	Extinctions
AROSA	GO:0043715	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity	Extinctions
AROSA	GO:0043716	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity	Extinctions
AROSA	GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	Extinctions
AROSA	GO:0008477	purine nucleosidase activity	Extinctions
AROSA	GO:0052716	hydroquinone:oxygen oxidoreductase activity	Extinctions
AROSA	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Extinctions
AROSA	GO:0050613	delta14-sterol reductase activity	Extinctions
AROSA	GO:0004332	fructose-bisphosphate aldolase activity	Extinctions
AROSA	GO:0034235	GPI anchor binding	Extinctions
AROSA	GO:0016034	maleylacetoacetate isomerase activity	Extinctions
AROSA	GO:0004190	aspartic-type endopeptidase activity	Extinctions
AROSA	GO:0070001	aspartic-type peptidase activity	Extinctions
AROSA	GO:0003690	double-stranded DNA binding	Extinctions
AROSA	GO:1990837	sequence-specific double-stranded DNA binding	Extinctions
HY3	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY3	GO:0034061	DNA polymerase activity	Gains
HY3	GO:0140097	catalytic activity, acting on DNA	Gains
HY3	GO:0003676	nucleic acid binding	Gains
HY3	GO:0016779	nucleotidyltransferase activity	Gains
HY3	GO:0005549	odorant binding	Gains
HY3	GO:0070001	aspartic-type peptidase activity	Gains
HY3	GO:0004190	aspartic-type endopeptidase activity	Gains
HY3	GO:0004984	olfactory receptor activity	Gains
HY3	GO:0004518	nuclease activity	Gains
HY3	GO:0008270	zinc ion binding	Gains
HY3	GO:1901363	heterocyclic compound binding	Gains
HY3	GO:0097159	organic cyclic compound binding	Gains
HY3	GO:0046914	transition metal ion binding	Gains
HY3	GO:0004519	endonuclease activity	Gains
HY3	GO:0004175	endopeptidase activity	Gains
HY3	GO:0003723	RNA binding	Gains
HY3	GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
HY3	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY3	GO:0008233	peptidase activity	Gains
HY3	GO:0043169	cation binding	Gains
HY3	GO:0046872	metal ion binding	Gains
HY3	GO:0003677	DNA binding	Gains
HY3	GO:0099600	transmembrane receptor activity	Gains
HY3	GO:0016788	hydrolase activity, acting on ester bonds	Gains
HY3	GO:0005488	binding	Gains
HY3	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY3	GO:0004888	transmembrane signaling receptor activity	Gains
HY3	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
HY3	GO:0004521	endoribonuclease activity	Gains
HY3	GO:0016787	hydrolase activity	Gains
HY3	GO:0038023	signaling receptor activity	Gains
HY3	GO:0004930	G-protein coupled receptor activity	Gains
HY3	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
HY3	GO:0004872	receptor activity	Gains
HY3	GO:0005230	extracellular ligand-gated ion channel activity	Gains
HY3	GO:0003678	DNA helicase activity	Gains
HY3	GO:0022824	transmitter-gated ion channel activity	Gains
HY3	GO:0022835	transmitter-gated channel activity	Gains
HY3	GO:0004970	ionotropic glutamate receptor activity	Gains
HY3	GO:0008236	serine-type peptidase activity	Gains
HY3	GO:0017171	serine hydrolase activity	Gains
HY3	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
HY3	GO:0060089	molecular transducer activity	Gains
HY3	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
HY3	GO:0022834	ligand-gated channel activity	Gains
HY3	GO:0015276	ligand-gated ion channel activity	Gains
HY3	GO:0008066	glutamate receptor activity	Gains
HY3	GO:0019955	cytokine binding	Gains
HY3	GO:0004871	signal transducer activity	Gains
HY3	GO:0004252	serine-type endopeptidase activity	Gains
HY3	GO:0004540	ribonuclease activity	Gains
HY3	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Gains
HY3	GO:0043138	3'-5' DNA helicase activity	Gains
HY3	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
HY3	GO:0008422	beta-glucosidase activity	Gains
HY3	GO:0018685	alkane 1-monooxygenase activity	Gains
HY3	GO:0050662	coenzyme binding	Gains
HY3	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
HY3	GO:0004803	transposase activity	Gains
HY3	GO:0030594	neurotransmitter receptor activity	Gains
HY3	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
HY3	GO:0050660	flavin adenine dinucleotide binding	Gains
HY3	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HY3	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Gains
HY3	GO:0004972	NMDA glutamate receptor activity	Gains
HY3	GO:0004185	serine-type carboxypeptidase activity	Gains
HY3	GO:0003990	acetylcholinesterase activity	Gains
HY3	GO:0004104	cholinesterase activity	Gains
HY3	GO:0004568	chitinase activity	Gains
HY3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
HY3	GO:0008527	taste receptor activity	Gains
HY3	GO:0001105	RNA polymerase II transcription coactivator activity	Gains
HY3	GO:0070008	serine-type exopeptidase activity	Gains
HY3	GO:0004736	pyruvate carboxylase activity	Gains
HY3	GO:0017110	nucleoside-diphosphatase activity	Gains
HY3	GO:0045134	uridine-diphosphatase activity	Gains
HY3	GO:0004563	beta-N-acetylhexosaminidase activity	Gains
HY3	GO:0008253	5'-nucleotidase activity	Gains
HY3	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	Gains
HY3	GO:0022836	gated channel activity	Gains
HY3	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
HY3	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HY3	GO:0050661	NADP binding	Gains
HY3	GO:0050254	rhodopsin kinase activity	Losses
HY3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
HY3	GO:0004983	neuropeptide Y receptor activity	Losses
HY3	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
HY3	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
HY3	GO:0052834	inositol monophosphate phosphatase activity	Losses
HY3	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
HY3	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
HY3	GO:0004950	chemokine receptor activity	Losses
HY3	GO:0008528	G-protein coupled peptide receptor activity	Losses
HY3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
HY3	GO:0004835	tubulin-tyrosine ligase activity	Losses
HY3	GO:0001653	peptide receptor activity	Losses
HY3	GO:0004896	cytokine receptor activity	Losses
HY3	GO:0008237	metallopeptidase activity	Losses
HY3	GO:0008188	neuropeptide receptor activity	Losses
HY3	GO:0004222	metalloendopeptidase activity	Losses
HY3	GO:0038023	signaling receptor activity	Losses
HY3	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
HY3	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
HY3	GO:0042578	phosphoric ester hydrolase activity	Losses
HY3	GO:0004165	dodecenoyl-CoA delta-isomerase activity	Losses
HY3	GO:0046872	metal ion binding	Losses
HY3	GO:0043169	cation binding	Losses
HY3	GO:0020037	heme binding	Losses
HY3	GO:0016791	phosphatase activity	Losses
HY3	GO:0046906	tetrapyrrole binding	Losses
HY3	GO:0043177	organic acid binding	Losses
HY3	GO:0031406	carboxylic acid binding	Losses
HY3	GO:0016597	amino acid binding	Losses
HY3	GO:0099600	transmembrane receptor activity	Losses
HY3	GO:0004879	nuclear receptor activity	Losses
HY3	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	Losses
HY3	GO:0004888	transmembrane signaling receptor activity	Losses
HY3	GO:1901681	sulfur compound binding	Losses
HY3	GO:0033218	amide binding	Losses
HY3	GO:0003680	AT DNA binding	Losses
HY3	GO:0008579	JUN kinase phosphatase activity	Losses
HY3	GO:0001106	RNA polymerase II transcription corepressor activity	Losses
HY3	GO:0004794	L-threonine ammonia-lyase activity	Losses
HY3	GO:0016841	ammonia-lyase activity	Losses
HY3	GO:0015054	gastrin receptor activity	Losses
HY3	GO:0043295	glutathione binding	Losses
HY3	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	Losses
HY3	GO:0001222	transcription corepressor binding	Losses
HY3	GO:0001226	RNA polymerase II transcription corepressor binding	Losses
HY3	GO:0016595	glutamate binding	Losses
HY3	GO:0008658	penicillin binding	Losses
HY3	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Losses
HY3	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Losses
HY3	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Losses
HY3	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Losses
HY3	GO:0019153	protein-disulfide reductase (glutathione) activity	Losses
HY3	GO:0019158	mannokinase activity	Losses
HY3	GO:0097109	neuroligin family protein binding	Losses
HY3	GO:0043560	insulin receptor substrate binding	Losses
HY3	GO:0043559	insulin binding	Losses
HY3	GO:0004634	phosphopyruvate hydratase activity	Losses
HY3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	Losses
HY3	GO:0005043	netrin receptor activity involved in chemorepulsion	Losses
HY3	GO:0005009	insulin-activated receptor activity	Losses
HY3	GO:0051425	PTB domain binding	Losses
HY3	GO:0001642	group III metabotropic glutamate receptor activity	Losses
HY3	GO:0034185	apolipoprotein binding	Losses
HY3	GO:1900750	oligopeptide binding	Losses
HY3	GO:0004020	adenylylsulfate kinase activity	Losses
HY3	GO:0004995	tachykinin receptor activity	Losses
HY3	GO:0071837	HMG box domain binding	Losses
HY3	GO:0070733	protein adenylyltransferase activity	Losses
HY3	GO:0070856	myosin VI light chain binding	Losses
HY3	GO:0004396	hexokinase activity	Losses
HY3	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Losses
HY3	GO:0004340	glucokinase activity	Losses
HY3	GO:0005104	fibroblast growth factor receptor binding	Losses
HY3	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Losses
HY3	GO:0003708	retinoic acid receptor activity	Losses
HY3	GO:0008865	fructokinase activity	Losses
HY3	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Losses
HY3	GO:0008881	glutamate racemase activity	Losses
HY3	GO:0016785	transferase activity, transferring selenium-containing groups	Losses
HY3	GO:0071906	CRD domain binding	Losses
HY3	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
HY3	GO:0004872	receptor activity	Losses
HY3	GO:0003700	DNA binding transcription factor activity	Losses
HY3	GO:0044212	transcription regulatory region DNA binding	Losses
HY3	GO:0008235	metalloexopeptidase activity	Losses
HY3	GO:0001067	regulatory region nucleic acid binding	Losses
HY3	GO:0000975	regulatory region DNA binding	Losses
HY3	GO:0060089	molecular transducer activity	Losses
HY3	GO:0016301	kinase activity	Losses
HY3	GO:0140110	transcription regulator activity	Losses
HY3	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
HY3	GO:1901567	fatty acid derivative binding	Losses
HY3	GO:0000062	fatty-acyl-CoA binding	Losses
HY3	GO:0050254	rhodopsin kinase activity	Extinctions
HY3	GO:0004835	tubulin-tyrosine ligase activity	Extinctions
HY3	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Extinctions
HY3	GO:0004983	neuropeptide Y receptor activity	Extinctions
HY3	GO:0008188	neuropeptide receptor activity	Extinctions
HY3	GO:0043177	organic acid binding	Extinctions
HY3	GO:0031406	carboxylic acid binding	Extinctions
HY3	GO:0016597	amino acid binding	Extinctions
HY3	GO:0042578	phosphoric ester hydrolase activity	Extinctions
HY3	GO:0008528	G-protein coupled peptide receptor activity	Extinctions
HY3	GO:0001653	peptide receptor activity	Extinctions
HY3	GO:0008235	metalloexopeptidase activity	Extinctions
HY3	GO:0046872	metal ion binding	Extinctions
HY3	GO:0016791	phosphatase activity	Extinctions
HY3	GO:0020037	heme binding	Extinctions
HY3	GO:0008579	JUN kinase phosphatase activity	Extinctions
HY3	GO:0004794	L-threonine ammonia-lyase activity	Extinctions
HY3	GO:0016841	ammonia-lyase activity	Extinctions
HY3	GO:0015054	gastrin receptor activity	Extinctions
HY3	GO:0043295	glutathione binding	Extinctions
HY3	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	Extinctions
HY3	GO:0016595	glutamate binding	Extinctions
HY3	GO:0008658	penicillin binding	Extinctions
HY3	GO:0046987	N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
HY3	GO:0046988	asioloorosomucoid beta-1,3-glucuronosyltransferase activity	Extinctions
HY3	GO:0046989	galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	Extinctions
HY3	GO:0019153	protein-disulfide reductase (glutathione) activity	Extinctions
HY3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	Extinctions
HY3	GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
HY3	GO:1900750	oligopeptide binding	Extinctions
HY3	GO:0070733	protein adenylyltransferase activity	Extinctions
HY3	GO:0070856	myosin VI light chain binding	Extinctions
HY3	GO:0005104	fibroblast growth factor receptor binding	Extinctions
HY3	GO:0003708	retinoic acid receptor activity	Extinctions
HY3	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
HY3	GO:0008881	glutamate racemase activity	Extinctions
HY3	GO:0016785	transferase activity, transferring selenium-containing groups	Extinctions
HY3	GO:0043169	cation binding	Extinctions
HY3	GO:0046906	tetrapyrrole binding	Extinctions
HY3	GO:0016849	phosphorus-oxygen lyase activity	Extinctions
HY3	GO:0008234	cysteine-type peptidase activity	Extinctions
HY3	GO:0004181	metallocarboxypeptidase activity	Extinctions
HY5	GO:0003964	RNA-directed DNA polymerase activity	Gains
HY5	GO:0034061	DNA polymerase activity	Gains
HY5	GO:0016779	nucleotidyltransferase activity	Gains
HY5	GO:0140097	catalytic activity, acting on DNA	Gains
HY5	GO:0004190	aspartic-type endopeptidase activity	Gains
HY5	GO:0070001	aspartic-type peptidase activity	Gains
HY5	GO:0003676	nucleic acid binding	Gains
HY5	GO:0046914	transition metal ion binding	Gains
HY5	GO:0005549	odorant binding	Gains
HY5	GO:0004518	nuclease activity	Gains
HY5	GO:0008270	zinc ion binding	Gains
HY5	GO:0004175	endopeptidase activity	Gains
HY5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
HY5	GO:0003954	NADH dehydrogenase activity	Gains
HY5	GO:0004129	cytochrome-c oxidase activity	Gains
HY5	GO:0015002	heme-copper terminal oxidase activity	Gains
HY5	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
HY5	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
HY5	GO:0008233	peptidase activity	Gains
HY5	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
HY5	GO:0018685	alkane 1-monooxygenase activity	Gains
HY5	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	Gains
HY5	GO:0016615	malate dehydrogenase activity	Gains
HY5	GO:0008137	NADH dehydrogenase (ubiquinone) activity	Gains
HY5	GO:0050136	NADH dehydrogenase (quinone) activity	Gains
HY5	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
HY5	GO:0004984	olfactory receptor activity	Gains
HY5	GO:0008812	choline dehydrogenase activity	Gains
HY5	GO:0009055	electron transfer activity	Gains
HY5	GO:0050660	flavin adenine dinucleotide binding	Gains
HY5	GO:0003677	DNA binding	Gains
HY5	GO:0010340	carboxyl-O-methyltransferase activity	Gains
HY5	GO:0051998	protein carboxyl O-methyltransferase activity	Gains
HY5	GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
HY5	GO:0004803	transposase activity	Gains
HY5	GO:0005215	transporter activity	Gains
HY5	GO:1901363	heterocyclic compound binding	Gains
HY5	GO:0097159	organic cyclic compound binding	Gains
HY5	GO:0016491	oxidoreductase activity	Gains
HY5	GO:0022857	transmembrane transporter activity	Gains
HY5	GO:0050662	coenzyme binding	Gains
HY5	GO:0004519	endonuclease activity	Gains
HY5	GO:0003723	RNA binding	Gains
HY5	GO:0048037	cofactor binding	Gains
HY5	GO:0015078	hydrogen ion transmembrane transporter activity	Gains
HY5	GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
HY5	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
HY5	GO:0004344	glucose dehydrogenase activity	Gains
HY5	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
HY5	GO:0004180	carboxypeptidase activity	Gains
HY5	GO:0008171	O-methyltransferase activity	Gains
HY5	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HY5	GO:0070330	aromatase activity	Gains
HY5	GO:0046872	metal ion binding	Gains
HY5	GO:0051192	prosthetic group binding	Gains
HY5	GO:0016415	octanoyltransferase activity	Gains
HY5	GO:0005347	ATP transmembrane transporter activity	Gains
HY5	GO:0030267	glyoxylate reductase (NADP) activity	Gains
HY5	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
HY5	GO:0044620	ACP phosphopantetheine attachment site binding	Gains
HY5	GO:0005471	ATP:ADP antiporter activity	Gains
HY5	GO:0005436	sodium:phosphate symporter activity	Gains
HY5	GO:0032183	SUMO binding	Gains
HY5	GO:0009703	nitrate reductase (NADH) activity	Gains
HY5	GO:0004321	fatty-acyl-CoA synthase activity	Gains
HY5	GO:0000036	acyl carrier activity	Gains
HY5	GO:0005125	cytokine activity	Gains
HY5	GO:0004304	estrone sulfotransferase activity	Gains
HY5	GO:0050232	putrescine oxidase activity	Gains
HY5	GO:0003839	gamma-glutamylcyclotransferase activity	Gains
HY5	GO:0004145	diamine N-acetyltransferase activity	Gains
HY5	GO:0004139	deoxyribose-phosphate aldolase activity	Gains
HY5	GO:0047886	farnesol dehydrogenase activity	Gains
HY5	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Gains
HY5	GO:0016502	nucleotide receptor activity	Gains
HY5	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	Gains
HY5	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
HY5	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
HY5	GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Gains
HY5	GO:0004796	thromboxane-A synthase activity	Gains
HY5	GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Gains
HY5	GO:0032542	sulfiredoxin activity	Gains
HY5	GO:0004747	ribokinase activity	Gains
HY5	GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
HY5	GO:0052870	tocopherol omega-hydroxylase activity	Gains
HY5	GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
HY5	GO:0035198	miRNA binding	Gains
HY5	GO:0003986	acetyl-CoA hydrolase activity	Gains
HY5	GO:0033819	lipoyl(octanoyl) transferase activity	Gains
HY5	GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
HY5	GO:0004667	prostaglandin-D synthase activity	Gains
HY5	GO:0004651	polynucleotide 5'-phosphatase activity	Gains
HY5	GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
HY5	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
HY5	GO:0047964	glyoxylate reductase activity	Gains
HY5	GO:0008940	nitrate reductase activity	Gains
HY5	GO:0008936	nicotinamidase activity	Gains
HY5	GO:0031177	phosphopantetheine binding	Gains
HY5	GO:0001614	purinergic nucleotide receptor activity	Gains
HY5	GO:0015217	ADP transmembrane transporter activity	Gains
HY5	GO:0018738	S-formylglutathione hydrolase activity	Gains
HY5	GO:0004062	aryl sulfotransferase activity	Gains
HY5	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Gains
HY5	GO:0036132	13-prostaglandin reductase activity	Gains
HY5	GO:0004027	alcohol sulfotransferase activity	Gains
HY5	GO:0004888	transmembrane signaling receptor activity	Losses
HY5	GO:0099600	transmembrane receptor activity	Losses
HY5	GO:0004930	G-protein coupled receptor activity	Losses
HY5	GO:0038023	signaling receptor activity	Losses
HY5	GO:0050254	rhodopsin kinase activity	Losses
HY5	GO:0004872	receptor activity	Losses
HY5	GO:0004970	ionotropic glutamate receptor activity	Losses
HY5	GO:0022824	transmitter-gated ion channel activity	Losses
HY5	GO:0022835	transmitter-gated channel activity	Losses
HY5	GO:0004035	alkaline phosphatase activity	Losses
HY5	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
HY5	GO:0060089	molecular transducer activity	Losses
HY5	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
HY5	GO:0004871	signal transducer activity	Losses
HY5	GO:0004983	neuropeptide Y receptor activity	Losses
HY5	GO:0008066	glutamate receptor activity	Losses
HY5	GO:0030594	neurotransmitter receptor activity	Losses
HY5	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
HY5	GO:0008241	peptidyl-dipeptidase activity	Losses
HY5	GO:0005230	extracellular ligand-gated ion channel activity	Losses
HY5	GO:0022834	ligand-gated channel activity	Losses
HY5	GO:0015276	ligand-gated ion channel activity	Losses
HY5	GO:0008188	neuropeptide receptor activity	Losses
HY5	GO:0008528	G-protein coupled peptide receptor activity	Losses
HY5	GO:0001653	peptide receptor activity	Losses
HY5	GO:0016499	orexin receptor activity	Losses
HY5	GO:0004995	tachykinin receptor activity	Losses
HY5	GO:0004971	AMPA glutamate receptor activity	Losses
HY5	GO:0008815	citrate (pro-3S)-lyase activity	Losses
HY5	GO:0008816	citryl-CoA lyase activity	Losses
HY5	GO:0042071	leucokinin receptor activity	Losses
HY5	GO:0003676	nucleic acid binding	Losses
HY5	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
HY5	GO:0008061	chitin binding	Losses
HY5	GO:0004950	chemokine receptor activity	Losses
HY5	GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
HY5	GO:0022836	gated channel activity	Losses
HY5	GO:0005216	ion channel activity	Losses
HY5	GO:0022838	substrate-specific channel activity	Losses
HY5	GO:0022803	passive transmembrane transporter activity	Losses
HY5	GO:0015267	channel activity	Losses
HY5	GO:0016833	oxo-acid-lyase activity	Losses
HY5	GO:0004896	cytokine receptor activity	Losses
HY5	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Losses
HY5	GO:0003677	DNA binding	Losses
HY5	GO:0030246	carbohydrate binding	Losses
HY5	GO:0004888	transmembrane signaling receptor activity	Extinctions
HY5	GO:0099600	transmembrane receptor activity	Extinctions
HY5	GO:0038023	signaling receptor activity	Extinctions
HY5	GO:0004930	G-protein coupled receptor activity	Extinctions
HY5	GO:0008241	peptidyl-dipeptidase activity	Extinctions
HY5	GO:0004970	ionotropic glutamate receptor activity	Extinctions
HY5	GO:0022824	transmitter-gated ion channel activity	Extinctions
HY5	GO:0022835	transmitter-gated channel activity	Extinctions
HY5	GO:0004872	receptor activity	Extinctions
HY5	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
HY5	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
HY5	GO:0008066	glutamate receptor activity	Extinctions
HY5	GO:0060089	molecular transducer activity	Extinctions
HY5	GO:0004871	signal transducer activity	Extinctions
HY5	GO:0030594	neurotransmitter receptor activity	Extinctions
HY5	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
HY5	GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
HY5	GO:0008816	citryl-CoA lyase activity	Extinctions
HY5	GO:0042071	leucokinin receptor activity	Extinctions
HY5	GO:0022834	ligand-gated channel activity	Extinctions
HY5	GO:0015276	ligand-gated ion channel activity	Extinctions
HY5	GO:0003677	DNA binding	Extinctions
HY5	GO:0004035	alkaline phosphatase activity	Extinctions
HY5	GO:0016833	oxo-acid-lyase activity	Extinctions
HY5	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Extinctions
HY5	GO:0005216	ion channel activity	Extinctions
HY5	GO:0022838	substrate-specific channel activity	Extinctions
HY5	GO:0022803	passive transmembrane transporter activity	Extinctions
HY5	GO:0015267	channel activity	Extinctions
HY5	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
HY5	GO:0008094	DNA-dependent ATPase activity	Extinctions
HY5	GO:0022836	gated channel activity	Extinctions
HY5	GO:0003676	nucleic acid binding	Extinctions
HY5	GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Extinctions
HY5	GO:0008172	S-methyltransferase activity	Extinctions
HY5	GO:0050254	rhodopsin kinase activity	Extinctions
HY7	GO:0004364	glutathione transferase activity	Gains
HY7	GO:0004602	glutathione peroxidase activity	Gains
HY7	GO:0004104	cholinesterase activity	Gains
HY7	GO:0003990	acetylcholinesterase activity	Gains
HY7	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
HY7	GO:0004190	aspartic-type endopeptidase activity	Gains
HY7	GO:0070001	aspartic-type peptidase activity	Gains
HY7	GO:0016860	intramolecular oxidoreductase activity	Gains
HY7	GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
HY7	GO:0018833	DDT-dehydrochlorinase activity	Gains
HY7	GO:0005550	pheromone binding	Gains
HY7	GO:0004667	prostaglandin-D synthase activity	Gains
HY7	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
HY7	GO:0004601	peroxidase activity	Gains
HY7	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
HY7	GO:0031386	protein tag	Gains
HY7	GO:0004348	glucosylceramidase activity	Gains
HY7	GO:0046423	allene-oxide cyclase activity	Gains
HY7	GO:0047396	glycosylphosphatidylinositol diacylglycerol-lyase activity	Gains
HY7	GO:0016848	carbon-halide lyase activity	Gains
HY7	GO:0050220	prostaglandin-E synthase activity	Gains
HY7	GO:0050591	quinine 3-monooxygenase activity	Gains
HY7	GO:0016209	antioxidant activity	Gains
HY7	GO:0005549	odorant binding	Gains
HY7	GO:0016802	trialkylsulfonium hydrolase activity	Gains
HY7	GO:0004013	adenosylhomocysteinase activity	Gains
HY7	GO:0008233	peptidase activity	Gains
HY7	GO:0003950	NAD+ ADP-ribosyltransferase activity	Gains
HY7	GO:0016829	lyase activity	Gains
HY7	GO:0003796	lysozyme activity	Gains
HY7	GO:0004344	glucose dehydrogenase activity	Gains
HY7	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
HY7	GO:0070330	aromatase activity	Gains
HY7	GO:0003677	DNA binding	Gains
HY7	GO:0003747	translation release factor activity	Gains
HY7	GO:0016801	hydrolase activity, acting on ether bonds	Gains
HY7	GO:0008079	translation termination factor activity	Gains
HY7	GO:0003676	nucleic acid binding	Gains
HY7	GO:0016853	isomerase activity	Gains
HY7	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
HY7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Gains
HY7	GO:0008812	choline dehydrogenase activity	Gains
HY7	GO:0004089	carbonate dehydratase activity	Gains
HY7	GO:0003964	RNA-directed DNA polymerase activity	Losses
HY7	GO:0016779	nucleotidyltransferase activity	Losses
HY7	GO:0034061	DNA polymerase activity	Losses
HY7	GO:0004334	fumarylacetoacetase activity	Losses
HY7	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Losses
HY7	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Losses
HY7	GO:0050897	cobalt ion binding	Losses
HY7	GO:0004038	allantoinase activity	Losses
HY7	GO:0035198	miRNA binding	Losses
HY7	GO:0140097	catalytic activity, acting on DNA	Losses
HY7	GO:0034736	cholesterol O-acyltransferase activity	Losses
HY7	GO:0004772	sterol O-acyltransferase activity	Losses
HY7	GO:0004519	endonuclease activity	Losses
HY7	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Losses
HY7	GO:0016859	cis-trans isomerase activity	Losses
HY7	GO:0035197	siRNA binding	Losses
HY7	GO:0047915	ganglioside galactosyltransferase activity	Losses
HY7	GO:0008036	diuretic hormone receptor activity	Losses
HY7	GO:0005154	epidermal growth factor receptor binding	Losses
HY7	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Losses
HY7	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
HY7	GO:0003960	NADPH:quinone reductase activity	Losses
HY7	GO:0004687	myosin light chain kinase activity	Losses
HY7	GO:0034062	5'-3' RNA polymerase activity	Losses
HY7	GO:0097747	RNA polymerase activity	Losses
HY7	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Losses
HY7	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Losses
HY7	GO:0070851	growth factor receptor binding	Losses
HY7	GO:0008194	UDP-glycosyltransferase activity	Losses
HY7	GO:0004334	fumarylacetoacetase activity	Extinctions
HY7	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	Extinctions
HY7	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	Extinctions
HY7	GO:0050897	cobalt ion binding	Extinctions
HY7	GO:0004038	allantoinase activity	Extinctions
HY7	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Extinctions
HY7	GO:0016859	cis-trans isomerase activity	Extinctions
HY7	GO:0034736	cholesterol O-acyltransferase activity	Extinctions
HY7	GO:0004772	sterol O-acyltransferase activity	Extinctions
HY7	GO:0047915	ganglioside galactosyltransferase activity	Extinctions
HY7	GO:0008036	diuretic hormone receptor activity	Extinctions
HY7	GO:0005154	epidermal growth factor receptor binding	Extinctions
HY7	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
HY7	GO:0008194	UDP-glycosyltransferase activity	Extinctions
HY7	GO:0003960	NADPH:quinone reductase activity	Extinctions
HY7	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
HY7	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	Extinctions
HY7	GO:0070851	growth factor receptor binding	Extinctions
HY7	GO:0035250	UDP-galactosyltransferase activity	Extinctions
HY7	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI5	GO:0005549	odorant binding	Gains
DI5	GO:0004984	olfactory receptor activity	Gains
DI5	GO:0004252	serine-type endopeptidase activity	Gains
DI5	GO:0008236	serine-type peptidase activity	Gains
DI5	GO:0017171	serine hydrolase activity	Gains
DI5	GO:0099600	transmembrane receptor activity	Gains
DI5	GO:0048038	quinone binding	Gains
DI5	GO:0004872	receptor activity	Gains
DI5	GO:0004930	G-protein coupled receptor activity	Gains
DI5	GO:0060089	molecular transducer activity	Gains
DI5	GO:0008270	zinc ion binding	Gains
DI5	GO:0004888	transmembrane signaling receptor activity	Gains
DI5	GO:0046872	metal ion binding	Gains
DI5	GO:0043169	cation binding	Gains
DI5	GO:0038023	signaling receptor activity	Gains
DI5	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Gains
DI5	GO:0046914	transition metal ion binding	Gains
DI5	GO:0050839	cell adhesion molecule binding	Gains
DI5	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
DI5	GO:0010997	anaphase-promoting complex binding	Gains
DI5	GO:0004854	xanthine dehydrogenase activity	Gains
DI5	GO:0004855	xanthine oxidase activity	Gains
DI5	GO:0004824	lysine-tRNA ligase activity	Gains
DI5	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Gains
DI5	GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	Gains
DI5	GO:0016727	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor	Gains
DI5	GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Gains
DI5	GO:0015026	coreceptor activity	Gains
DI5	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Gains
DI5	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Gains
DI5	GO:0033858	N-acetylgalactosamine kinase activity	Gains
DI5	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Gains
DI5	GO:0070976	TIR domain binding	Gains
DI5	GO:0019789	SUMO transferase activity	Gains
DI5	GO:0004398	histidine decarboxylase activity	Gains
DI5	GO:0009881	photoreceptor activity	Gains
DI5	GO:0008233	peptidase activity	Gains
DI5	GO:0004181	metallocarboxypeptidase activity	Gains
DI5	GO:0004175	endopeptidase activity	Gains
DI5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI5	GO:0004335	galactokinase activity	Gains
DI5	GO:0034736	cholesterol O-acyltransferase activity	Gains
DI5	GO:0043546	molybdopterin cofactor binding	Gains
DI5	GO:0022829	wide pore channel activity	Gains
DI5	GO:0004772	sterol O-acyltransferase activity	Gains
DI5	GO:0004833	tryptophan 2,3-dioxygenase activity	Gains
DI5	GO:0004837	tyrosine decarboxylase activity	Gains
DI5	GO:0070883	pre-miRNA binding	Gains
DI5	GO:0031072	heat shock protein binding	Gains
DI5	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	Gains
DI5	GO:0004995	tachykinin receptor activity	Gains
DI5	GO:0036422	heptaprenyl diphosphate synthase activity	Gains
DI5	GO:0019788	NEDD8 transferase activity	Gains
DI5	GO:0005243	gap junction channel activity	Gains
DI5	GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
DI5	GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
DI5	GO:0008233	peptidase activity	Losses
DI5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
DI5	GO:0042562	hormone binding	Losses
DI5	GO:0140096	catalytic activity, acting on a protein	Losses
DI5	GO:0019811	cocaine binding	Losses
DI5	GO:0015175	neutral amino acid transmembrane transporter activity	Losses
DI5	GO:0042943	D-amino acid transmembrane transporter activity	Losses
DI5	GO:0015222	serotonin transmembrane transporter activity	Losses
DI5	GO:0034584	piRNA binding	Losses
DI5	GO:0033932	1,3-alpha-L-fucosidase activity	Losses
DI5	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	Losses
DI5	GO:0005329	dopamine transmembrane transporter activity	Losses
DI5	GO:0035237	corazonin receptor activity	Losses
DI5	GO:0004946	bombesin receptor activity	Losses
DI5	GO:0061778	intracellular chloride channel activity	Losses
DI5	GO:0046920	alpha-(1->3)-fucosyltransferase activity	Losses
DI5	GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Losses
DI5	GO:0005229	intracellular calcium activated chloride channel activity	Losses
DI5	GO:0004930	G-protein coupled receptor activity	Losses
DI5	GO:0038023	signaling receptor activity	Losses
DI5	GO:0008237	metallopeptidase activity	Losses
DI5	GO:0008509	anion transmembrane transporter activity	Losses
DI5	GO:0004871	signal transducer activity	Losses
DI5	GO:0004175	endopeptidase activity	Losses
DI5	GO:0008890	glycine C-acetyltransferase activity	Losses
DI5	GO:0070405	ammonium ion binding	Losses
DI5	GO:0008504	monoamine transmembrane transporter activity	Losses
DI5	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
DI5	GO:0097003	adipokinetic hormone receptor activity	Losses
DI5	GO:0097004	adipokinetic hormone binding	Losses
DI5	GO:0004560	alpha-L-fucosidase activity	Losses
DI5	GO:0030546	receptor activator activity	Losses
DI5	GO:0005391	sodium:potassium-exchanging ATPase activity	Losses
DI5	GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
DI5	GO:0004046	aminoacylase activity	Losses
DI5	GO:0015928	fucosidase activity	Losses
DI5	GO:0004888	transmembrane signaling receptor activity	Losses
DI5	GO:0008234	cysteine-type peptidase activity	Losses
DI5	GO:0016787	hydrolase activity	Losses
DI5	GO:0008188	neuropeptide receptor activity	Losses
DI5	GO:0015439	heme-transporting ATPase activity	Losses
DI5	GO:0015232	heme transporter activity	Losses
DI5	GO:0017056	structural constituent of nuclear pore	Losses
DI5	GO:0016453	C-acetyltransferase activity	Losses
DI5	GO:0017046	peptide hormone binding	Losses
DI5	GO:0005416	cation:amino acid symporter activity	Losses
DI5	GO:0008261	allatostatin receptor activity	Losses
DI5	GO:0005283	sodium:amino acid symporter activity	Losses
DI5	GO:0008270	zinc ion binding	Losses
DI5	GO:0099600	transmembrane receptor activity	Losses
DI5	GO:0008528	G-protein coupled peptide receptor activity	Losses
DI5	GO:0008556	potassium-transporting ATPase activity	Losses
DI5	GO:0008519	ammonium transmembrane transporter activity	Losses
DI5	GO:0030296	protein tyrosine kinase activator activity	Losses
DI5	GO:0008308	voltage-gated anion channel activity	Losses
DI5	GO:0005487	nucleocytoplasmic transporter activity	Losses
DI5	GO:0005247	voltage-gated chloride channel activity	Losses
DI5	GO:0001653	peptide receptor activity	Losses
DI5	GO:0004872	receptor activity	Losses
DI5	GO:0004526	ribonuclease P activity	Losses
DI5	GO:0005343	organic acid:sodium symporter activity	Losses
DI5	GO:0008417	fucosyltransferase activity	Losses
DI5	GO:0016500	protein-hormone receptor activity	Losses
DI5	GO:0050254	rhodopsin kinase activity	Losses
DI5	GO:0060089	molecular transducer activity	Losses
DI5	GO:0015179	L-amino acid transmembrane transporter activity	Losses
DI5	GO:0030295	protein kinase activator activity	Losses
DI5	GO:0004869	cysteine-type endopeptidase inhibitor activity	Losses
DI5	GO:0051184	cofactor transporter activity	Losses
DI5	GO:0004047	aminomethyltransferase activity	Losses
DI5	GO:0019209	kinase activator activity	Losses
DI5	GO:0008233	peptidase activity	Extinctions
DI5	GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
DI5	GO:0008234	cysteine-type peptidase activity	Extinctions
DI5	GO:0004175	endopeptidase activity	Extinctions
DI5	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
DI5	GO:0030546	receptor activator activity	Extinctions
DI5	GO:0017056	structural constituent of nuclear pore	Extinctions
DI5	GO:0030296	protein tyrosine kinase activator activity	Extinctions
DI5	GO:0005487	nucleocytoplasmic transporter activity	Extinctions
DI5	GO:0004526	ribonuclease P activity	Extinctions
DI5	GO:0004222	metalloendopeptidase activity	Extinctions
DI5	GO:0030295	protein kinase activator activity	Extinctions
DI5	GO:0019209	kinase activator activity	Extinctions
DI5	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI5	GO:0140096	catalytic activity, acting on a protein	Extinctions
DI5	GO:0004519	endonuclease activity	Extinctions
DI5	GO:0004549	tRNA-specific ribonuclease activity	Extinctions
DI5	GO:0016787	hydrolase activity	Extinctions
DI5	GO:0031490	chromatin DNA binding	Extinctions
DI5	GO:0003676	nucleic acid binding	Extinctions
DI5	GO:0003682	chromatin binding	Extinctions
DI5	GO:0034061	DNA polymerase activity	Extinctions
DI5	GO:0004843	thiol-dependent ubiquitin-specific protease activity	Extinctions
DI5	GO:0101005	ubiquitinyl hydrolase activity	Extinctions
DI5	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Extinctions
DI7	GO:0005216	ion channel activity	Gains
DI7	GO:0022838	substrate-specific channel activity	Gains
DI7	GO:0022803	passive transmembrane transporter activity	Gains
DI7	GO:0015267	channel activity	Gains
DI7	GO:0022836	gated channel activity	Gains
DI7	GO:0099600	transmembrane receptor activity	Gains
DI7	GO:0005261	cation channel activity	Gains
DI7	GO:0004888	transmembrane signaling receptor activity	Gains
DI7	GO:0004871	signal transducer activity	Gains
DI7	GO:0004252	serine-type endopeptidase activity	Gains
DI7	GO:0015075	ion transmembrane transporter activity	Gains
DI7	GO:0005549	odorant binding	Gains
DI7	GO:0038023	signaling receptor activity	Gains
DI7	GO:0004930	G-protein coupled receptor activity	Gains
DI7	GO:0004984	olfactory receptor activity	Gains
DI7	GO:0022857	transmembrane transporter activity	Gains
DI7	GO:0004872	receptor activity	Gains
DI7	GO:0046873	metal ion transmembrane transporter activity	Gains
DI7	GO:0008236	serine-type peptidase activity	Gains
DI7	GO:0017171	serine hydrolase activity	Gains
DI7	GO:0022891	substrate-specific transmembrane transporter activity	Gains
DI7	GO:0022890	inorganic cation transmembrane transporter activity	Gains
DI7	GO:0008324	cation transmembrane transporter activity	Gains
DI7	GO:0022843	voltage-gated cation channel activity	Gains
DI7	GO:0022892	substrate-specific transporter activity	Gains
DI7	GO:0060089	molecular transducer activity	Gains
DI7	GO:0005215	transporter activity	Gains
DI7	GO:0005267	potassium channel activity	Gains
DI7	GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
DI7	GO:0005249	voltage-gated potassium channel activity	Gains
DI7	GO:0022832	voltage-gated channel activity	Gains
DI7	GO:0005244	voltage-gated ion channel activity	Gains
DI7	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI7	GO:0015079	potassium ion transmembrane transporter activity	Gains
DI7	GO:0004568	chitinase activity	Gains
DI7	GO:0005227	calcium activated cation channel activity	Gains
DI7	GO:0005262	calcium channel activity	Gains
DI7	GO:0022839	ion gated channel activity	Gains
DI7	GO:0022834	ligand-gated channel activity	Gains
DI7	GO:0015276	ligand-gated ion channel activity	Gains
DI7	GO:0004175	endopeptidase activity	Gains
DI7	GO:0008233	peptidase activity	Gains
DI7	GO:0017128	phospholipid scramblase activity	Gains
DI7	GO:0008331	high voltage-gated calcium channel activity	Gains
DI7	GO:0005415	nucleoside:sodium symporter activity	Gains
DI7	GO:0031418	L-ascorbic acid binding	Gains
DI7	GO:0022824	transmitter-gated ion channel activity	Gains
DI7	GO:0022835	transmitter-gated channel activity	Gains
DI7	GO:0004970	ionotropic glutamate receptor activity	Gains
DI7	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
DI7	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DI7	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
DI7	GO:0048029	monosaccharide binding	Gains
DI7	GO:0008066	glutamate receptor activity	Gains
DI7	GO:0005326	neurotransmitter transporter activity	Gains
DI7	GO:0004657	proline dehydrogenase activity	Gains
DI7	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Gains
DI7	GO:0015927	trehalase activity	Gains
DI7	GO:0008332	low voltage-gated calcium channel activity	Gains
DI7	GO:0008452	RNA ligase activity	Gains
DI7	GO:0004821	histidine-tRNA ligase activity	Gains
DI7	GO:0003997	acyl-CoA oxidase activity	Gains
DI7	GO:0004555	alpha,alpha-trehalase activity	Gains
DI7	GO:0015085	calcium ion transmembrane transporter activity	Gains
DI7	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
DI7	GO:0008171	O-methyltransferase activity	Losses
DI7	GO:0016788	hydrolase activity, acting on ester bonds	Losses
DI7	GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
DI7	GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
DI7	GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
DI7	GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
DI7	GO:0052834	inositol monophosphate phosphatase activity	Losses
DI7	GO:0015288	porin activity	Losses
DI7	GO:0004064	arylesterase activity	Losses
DI7	GO:0051010	microtubule plus-end binding	Losses
DI7	GO:0004462	lactoylglutathione lyase activity	Losses
DI7	GO:0050113	inositol oxygenase activity	Losses
DI7	GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
DI7	GO:0004540	ribonuclease activity	Losses
DI7	GO:0016830	carbon-carbon lyase activity	Losses
DI7	GO:0004518	nuclease activity	Losses
DI7	GO:0016831	carboxy-lyase activity	Losses
DI7	GO:0003824	catalytic activity	Losses
DI7	GO:0030247	polysaccharide binding	Losses
DI7	GO:0001871	pattern binding	Losses
DI7	GO:0003713	transcription coactivator activity	Losses
DI7	GO:0004067	asparaginase activity	Losses
DI7	GO:0008329	signaling pattern recognition receptor activity	Losses
DI7	GO:0022829	wide pore channel activity	Losses
DI7	GO:0038187	pattern recognition receptor activity	Losses
DI7	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Losses
DI7	GO:0016779	nucleotidyltransferase activity	Losses
DI7	GO:0016787	hydrolase activity	Losses
DI7	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI7	GO:0004180	carboxypeptidase activity	Losses
DI7	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Losses
DI7	GO:0051766	inositol trisphosphate kinase activity	Losses
DI7	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
DI7	GO:0008514	organic anion transmembrane transporter activity	Losses
DI7	GO:0004519	endonuclease activity	Losses
DI7	GO:0016829	lyase activity	Losses
DI7	GO:0016803	ether hydrolase activity	Losses
DI7	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	Losses
DI7	GO:0008484	sulfuric ester hydrolase activity	Losses
DI7	GO:0019203	carbohydrate phosphatase activity	Losses
DI7	GO:0008242	omega peptidase activity	Losses
DI7	GO:0008083	growth factor activity	Losses
DI7	GO:0004527	exonuclease activity	Losses
DI7	GO:0019239	deaminase activity	Losses
DI7	GO:0008509	anion transmembrane transporter activity	Losses
DI7	GO:0016740	transferase activity	Losses
DI7	GO:0016846	carbon-sulfur lyase activity	Losses
DI7	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
DI7	GO:0042834	peptidoglycan binding	Losses
DI7	GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
DI7	GO:0000987	core promoter proximal region sequence-specific DNA binding	Losses
DI7	GO:0001159	core promoter proximal region DNA binding	Losses
DI7	GO:0031208	POZ domain binding	Losses
DI7	GO:0004521	endoribonuclease activity	Losses
DI7	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
DI7	GO:0015288	porin activity	Extinctions
DI7	GO:0003713	transcription coactivator activity	Extinctions
DI7	GO:0016779	nucleotidyltransferase activity	Extinctions
DI7	GO:0051010	microtubule plus-end binding	Extinctions
DI7	GO:0004462	lactoylglutathione lyase activity	Extinctions
DI7	GO:0050113	inositol oxygenase activity	Extinctions
DI7	GO:0022829	wide pore channel activity	Extinctions
DI7	GO:0016830	carbon-carbon lyase activity	Extinctions
DI7	GO:0004540	ribonuclease activity	Extinctions
DI7	GO:0016846	carbon-sulfur lyase activity	Extinctions
DI7	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
DI7	GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
DI7	GO:0016831	carboxy-lyase activity	Extinctions
DI7	GO:0034062	5'-3' RNA polymerase activity	Extinctions
DI7	GO:0097747	RNA polymerase activity	Extinctions
DI7	GO:0004518	nuclease activity	Extinctions
DI7	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Extinctions
DI7	GO:0003712	transcription cofactor activity	Extinctions
DI7	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
DI7	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI7	GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Extinctions
DI7	GO:0070742	C2H2 zinc finger domain binding	Extinctions
DI7	GO:0008903	hydroxypyruvate isomerase activity	Extinctions
DI7	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	Extinctions
DI7	GO:0016503	pheromone receptor activity	Extinctions
DI7	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
DI7	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
DI7	GO:0034038	deoxyhypusine synthase activity	Extinctions
DI7	GO:0008488	gamma-glutamyl carboxylase activity	Extinctions
DI7	GO:0008478	pyridoxal kinase activity	Extinctions
DI7	GO:0005125	cytokine activity	Extinctions
DI7	GO:0004371	glycerone kinase activity	Extinctions
DI7	GO:0004325	ferrochelatase activity	Extinctions
DI7	GO:0018271	biotin-protein ligase activity	Extinctions
DI7	GO:0015266	protein channel activity	Extinctions
DI7	GO:0033897	ribonuclease T2 activity	Extinctions
DI7	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	Extinctions
DI7	GO:0003867	4-aminobutyrate transaminase activity	Extinctions
DI7	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity	Extinctions
DI7	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	Extinctions
DI7	GO:0004163	diphosphomevalonate decarboxylase activity	Extinctions
DI7	GO:0017050	D-erythro-sphingosine kinase activity	Extinctions
DI7	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
DI7	GO:0044748	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	Extinctions
DI7	GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	Extinctions
DI7	GO:0004590	orotidine-5'-phosphate decarboxylase activity	Extinctions
DI7	GO:0003999	adenine phosphoribosyltransferase activity	Extinctions
DI7	GO:0004588	orotate phosphoribosyltransferase activity	Extinctions
DI7	GO:0004573	mannosyl-oligosaccharide glucosidase activity	Extinctions
DI7	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	Extinctions
DI7	GO:0140098	catalytic activity, acting on RNA	Extinctions
DI7	GO:0004519	endonuclease activity	Extinctions
DI7	GO:0030247	polysaccharide binding	Extinctions
DI7	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
DI7	GO:0001871	pattern binding	Extinctions
DI7	GO:0000988	transcription factor activity, protein binding	Extinctions
DI7	GO:0000989	transcription factor activity, transcription factor binding	Extinctions
DI7	GO:0004521	endoribonuclease activity	Extinctions
DI1	GO:0046914	transition metal ion binding	Gains
DI1	GO:0008270	zinc ion binding	Gains
DI1	GO:0046872	metal ion binding	Gains
DI1	GO:0043169	cation binding	Gains
DI1	GO:0005549	odorant binding	Gains
DI1	GO:0004252	serine-type endopeptidase activity	Gains
DI1	GO:0017171	serine hydrolase activity	Gains
DI1	GO:0008236	serine-type peptidase activity	Gains
DI1	GO:0004175	endopeptidase activity	Gains
DI1	GO:0004497	monooxygenase activity	Gains
DI1	GO:0005506	iron ion binding	Gains
DI1	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI1	GO:0004984	olfactory receptor activity	Gains
DI1	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
DI1	GO:0008233	peptidase activity	Gains
DI1	GO:0043167	ion binding	Gains
DI1	GO:0016491	oxidoreductase activity	Gains
DI1	GO:0047077	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	Gains
DI1	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
DI1	GO:0003676	nucleic acid binding	Gains
DI1	GO:0020037	heme binding	Gains
DI1	GO:0004180	carboxypeptidase activity	Gains
DI1	GO:0046906	tetrapyrrole binding	Gains
DI1	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
DI1	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
DI1	GO:0070330	aromatase activity	Gains
DI1	GO:0030246	carbohydrate binding	Gains
DI1	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
DI1	GO:0004930	G-protein coupled receptor activity	Gains
DI1	GO:0045289	luciferin monooxygenase activity	Gains
DI1	GO:0004888	transmembrane signaling receptor activity	Gains
DI1	GO:0099600	transmembrane receptor activity	Gains
DI1	GO:0008527	taste receptor activity	Gains
DI1	GO:0048029	monosaccharide binding	Gains
DI1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
DI1	GO:0004033	aldo-keto reductase (NADP) activity	Gains
DI1	GO:0008198	ferrous iron binding	Gains
DI1	GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
DI1	GO:0018685	alkane 1-monooxygenase activity	Gains
DI1	GO:0004470	malic enzyme activity	Gains
DI1	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
DI1	GO:0005212	structural constituent of eye lens	Gains
DI1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
DI1	GO:0050591	quinine 3-monooxygenase activity	Gains
DI1	GO:0016848	carbon-halide lyase activity	Gains
DI1	GO:0043874	acireductone synthase activity	Gains
DI1	GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
DI1	GO:0015377	cation:chloride symporter activity	Gains
DI1	GO:0004503	monophenol monooxygenase activity	Gains
DI1	GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
DI1	GO:0004872	receptor activity	Gains
DI1	GO:0008237	metallopeptidase activity	Gains
DI1	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
DI1	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
DI1	GO:0071949	FAD binding	Gains
DI1	GO:0038023	signaling receptor activity	Gains
DI1	GO:0008010	structural constituent of chitin-based larval cuticle	Gains
DI1	GO:0031409	pigment binding	Gains
DI1	GO:0060089	molecular transducer activity	Gains
DI1	GO:0004970	ionotropic glutamate receptor activity	Gains
DI1	GO:0022824	transmitter-gated ion channel activity	Gains
DI1	GO:0022835	transmitter-gated channel activity	Gains
DI1	GO:0015293	symporter activity	Gains
DI1	GO:0031418	L-ascorbic acid binding	Gains
DI1	GO:0016615	malate dehydrogenase activity	Gains
DI1	GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
DI1	GO:0004129	cytochrome-c oxidase activity	Gains
DI1	GO:0015002	heme-copper terminal oxidase activity	Gains
DI1	GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
DI1	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
DI1	GO:0003964	RNA-directed DNA polymerase activity	Gains
DI1	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
DI1	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI1	GO:0016779	nucleotidyltransferase activity	Losses
DI1	GO:0034061	DNA polymerase activity	Losses
DI1	GO:0003677	DNA binding	Losses
DI1	GO:0140097	catalytic activity, acting on DNA	Losses
DI1	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DI1	GO:0004518	nuclease activity	Losses
DI1	GO:0004842	ubiquitin-protein transferase activity	Losses
DI1	GO:0019787	ubiquitin-like protein transferase activity	Losses
DI1	GO:0038023	signaling receptor activity	Losses
DI1	GO:0004871	signal transducer activity	Losses
DI1	GO:0003700	DNA binding transcription factor activity	Losses
DI1	GO:0034452	dynactin binding	Losses
DI1	GO:0008270	zinc ion binding	Losses
DI1	GO:0003676	nucleic acid binding	Losses
DI1	GO:0046914	transition metal ion binding	Losses
DI1	GO:0043565	sequence-specific DNA binding	Losses
DI1	GO:0003707	steroid hormone receptor activity	Losses
DI1	GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
DI1	GO:0004519	endonuclease activity	Losses
DI1	GO:0004000	adenosine deaminase activity	Losses
DI1	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
DI1	GO:0004872	receptor activity	Losses
DI1	GO:0005384	manganese ion transmembrane transporter activity	Losses
DI1	GO:0015927	trehalase activity	Losses
DI1	GO:0004555	alpha,alpha-trehalase activity	Losses
DI1	GO:0140110	transcription regulator activity	Losses
DI1	GO:0060089	molecular transducer activity	Losses
DI1	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
DI1	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Losses
DI1	GO:0005160	transforming growth factor beta receptor binding	Losses
DI1	GO:0009022	tRNA nucleotidyltransferase activity	Losses
DI1	GO:0004687	myosin light chain kinase activity	Losses
DI1	GO:0050321	tau-protein kinase activity	Losses
DI1	GO:1901363	heterocyclic compound binding	Losses
DI1	GO:0004970	ionotropic glutamate receptor activity	Losses
DI1	GO:0022824	transmitter-gated ion channel activity	Losses
DI1	GO:0022835	transmitter-gated channel activity	Losses
DI1	GO:0097159	organic cyclic compound binding	Losses
DI1	GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
DI1	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
DI1	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
DI1	GO:0008066	glutamate receptor activity	Losses
DI1	GO:0019239	deaminase activity	Losses
DI1	GO:0003678	DNA helicase activity	Losses
DI1	GO:0004521	endoribonuclease activity	Losses
DI1	GO:0005126	cytokine receptor binding	Losses
DI1	GO:0061659	ubiquitin-like protein ligase activity	Losses
DI1	GO:0061630	ubiquitin protein ligase activity	Losses
DI1	GO:0034450	ubiquitin-ubiquitin ligase activity	Losses
DI1	GO:0030306	ADP-ribosylation factor binding	Losses
DI1	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
DI1	GO:0004888	transmembrane signaling receptor activity	Losses
DI1	GO:0030594	neurotransmitter receptor activity	Losses
DI1	GO:0005375	copper ion transmembrane transporter activity	Losses
DI1	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Losses
DI1	GO:0004672	protein kinase activity	Losses
DI1	GO:0005381	iron ion transmembrane transporter activity	Losses
DI1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
DI1	GO:0099600	transmembrane receptor activity	Losses
DI1	GO:0005230	extracellular ligand-gated ion channel activity	Losses
DI1	GO:0016779	nucleotidyltransferase activity	Extinctions
DI1	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI1	GO:0034452	dynactin binding	Extinctions
DI1	GO:0005384	manganese ion transmembrane transporter activity	Extinctions
DI1	GO:0004842	ubiquitin-protein transferase activity	Extinctions
DI1	GO:0019787	ubiquitin-like protein transferase activity	Extinctions
DI1	GO:0004970	ionotropic glutamate receptor activity	Extinctions
DI1	GO:0022824	transmitter-gated ion channel activity	Extinctions
DI1	GO:0022835	transmitter-gated channel activity	Extinctions
DI1	GO:0034061	DNA polymerase activity	Extinctions
DI1	GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
DI1	GO:0140097	catalytic activity, acting on DNA	Extinctions
DI1	GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
DI1	GO:0008066	glutamate receptor activity	Extinctions
DI1	GO:0005160	transforming growth factor beta receptor binding	Extinctions
DI1	GO:0009022	tRNA nucleotidyltransferase activity	Extinctions
DI1	GO:0004687	myosin light chain kinase activity	Extinctions
DI1	GO:0003678	DNA helicase activity	Extinctions
DI1	GO:0003677	DNA binding	Extinctions
DI1	GO:0030594	neurotransmitter receptor activity	Extinctions
DI1	GO:0005126	cytokine receptor binding	Extinctions
DI1	GO:0061659	ubiquitin-like protein ligase activity	Extinctions
DI1	GO:0061630	ubiquitin protein ligase activity	Extinctions
DI1	GO:0034450	ubiquitin-ubiquitin ligase activity	Extinctions
DI1	GO:0030306	ADP-ribosylation factor binding	Extinctions
DI1	GO:0046914	transition metal ion binding	Extinctions
DI1	GO:0008270	zinc ion binding	Extinctions
DI1	GO:0005375	copper ion transmembrane transporter activity	Extinctions
DI1	GO:0005381	iron ion transmembrane transporter activity	Extinctions
DI1	GO:0003676	nucleic acid binding	Extinctions
DI1	GO:0005230	extracellular ligand-gated ion channel activity	Extinctions
DI1	GO:0004518	nuclease activity	Extinctions
DI1	GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
DI1	GO:0015276	ligand-gated ion channel activity	Extinctions
DI1	GO:0022834	ligand-gated channel activity	Extinctions
DI1	GO:0051015	actin filament binding	Extinctions
DI1	GO:0004519	endonuclease activity	Extinctions
DI3	GO:0005549	odorant binding	Gains
DI3	GO:0004252	serine-type endopeptidase activity	Gains
DI3	GO:0008236	serine-type peptidase activity	Gains
DI3	GO:0017171	serine hydrolase activity	Gains
DI3	GO:0004984	olfactory receptor activity	Gains
DI3	GO:0004930	G-protein coupled receptor activity	Gains
DI3	GO:0004175	endopeptidase activity	Gains
DI3	GO:0099600	transmembrane receptor activity	Gains
DI3	GO:0008233	peptidase activity	Gains
DI3	GO:0004888	transmembrane signaling receptor activity	Gains
DI3	GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
DI3	GO:0008061	chitin binding	Gains
DI3	GO:0038023	signaling receptor activity	Gains
DI3	GO:0004872	receptor activity	Gains
DI3	GO:0060089	molecular transducer activity	Gains
DI3	GO:0046914	transition metal ion binding	Gains
DI3	GO:0004871	signal transducer activity	Gains
DI3	GO:0008270	zinc ion binding	Gains
DI3	GO:0004497	monooxygenase activity	Gains
DI3	GO:0004568	chitinase activity	Gains
DI3	GO:0022836	gated channel activity	Gains
DI3	GO:0046872	metal ion binding	Gains
DI3	GO:0043169	cation binding	Gains
DI3	GO:0008527	taste receptor activity	Gains
DI3	GO:0005249	voltage-gated potassium channel activity	Gains
DI3	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
DI3	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
DI3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
DI3	GO:0005230	extracellular ligand-gated ion channel activity	Gains
DI3	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
DI3	GO:0005216	ion channel activity	Gains
DI3	GO:0022843	voltage-gated cation channel activity	Gains
DI3	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
DI3	GO:0022838	substrate-specific channel activity	Gains
DI3	GO:0015276	ligand-gated ion channel activity	Gains
DI3	GO:0022834	ligand-gated channel activity	Gains
DI3	GO:0015267	channel activity	Gains
DI3	GO:0022803	passive transmembrane transporter activity	Gains
DI3	GO:0030594	neurotransmitter receptor activity	Gains
DI3	GO:0008066	glutamate receptor activity	Gains
DI3	GO:0005506	iron ion binding	Gains
DI3	GO:0042302	structural constituent of cuticle	Gains
DI3	GO:0003964	RNA-directed DNA polymerase activity	Losses
DI3	GO:0034061	DNA polymerase activity	Losses
DI3	GO:0008270	zinc ion binding	Losses
DI3	GO:0140097	catalytic activity, acting on DNA	Losses
DI3	GO:0046914	transition metal ion binding	Losses
DI3	GO:0016779	nucleotidyltransferase activity	Losses
DI3	GO:0003677	DNA binding	Losses
DI3	GO:0046872	metal ion binding	Losses
DI3	GO:0043169	cation binding	Losses
DI3	GO:0070001	aspartic-type peptidase activity	Losses
DI3	GO:0004190	aspartic-type endopeptidase activity	Losses
DI3	GO:0004687	myosin light chain kinase activity	Losses
DI3	GO:0016787	hydrolase activity	Losses
DI3	GO:0008233	peptidase activity	Losses
DI3	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Losses
DI3	GO:0140110	transcription regulator activity	Losses
DI3	GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
DI3	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
DI3	GO:0043565	sequence-specific DNA binding	Losses
DI3	GO:0035250	UDP-galactosyltransferase activity	Losses
DI3	GO:0004519	endonuclease activity	Losses
DI3	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Losses
DI3	GO:0032028	myosin head/neck binding	Losses
DI3	GO:0031489	myosin V binding	Losses
DI3	GO:0015250	water channel activity	Losses
DI3	GO:0008986	pyruvate, water dikinase activity	Losses
DI3	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Losses
DI3	GO:0043998	H2A histone acetyltransferase activity	Losses
DI3	GO:0005372	water transmembrane transporter activity	Losses
DI3	GO:0033904	dextranase activity	Losses
DI3	GO:0004396	hexokinase activity	Losses
DI3	GO:0015098	molybdate ion transmembrane transporter activity	Losses
DI3	GO:0004340	glucokinase activity	Losses
DI3	GO:0004301	epoxide hydrolase activity	Losses
DI3	GO:0004474	malate synthase activity	Losses
DI3	GO:0008747	N-acetylneuraminate lyase activity	Losses
DI3	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Losses
DI3	GO:0008865	fructokinase activity	Losses
DI3	GO:0019158	mannokinase activity	Losses
DI3	GO:0070854	myosin VI heavy chain binding	Losses
DI3	GO:0070855	myosin VI head/neck binding	Losses
DI3	GO:0008805	carbon-monoxide oxygenase activity	Losses
DI3	GO:0003700	DNA binding transcription factor activity	Losses
DI3	GO:0005215	transporter activity	Losses
DI3	GO:0043167	ion binding	Losses
DI3	GO:0008378	galactosyltransferase activity	Losses
DI3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Losses
DI3	GO:0015440	peptide-transporting ATPase activity	Losses
DI3	GO:0004852	uroporphyrinogen-III synthase activity	Losses
DI3	GO:0050699	WW domain binding	Losses
DI3	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding	Losses
DI3	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
DI3	GO:0015562	efflux transmembrane transporter activity	Losses
DI3	GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
DI3	GO:0004046	aminoacylase activity	Losses
DI3	GO:0004971	AMPA glutamate receptor activity	Losses
DI3	GO:0008260	3-oxoacid CoA-transferase activity	Losses
DI3	GO:0016833	oxo-acid-lyase activity	Losses
DI3	GO:0047712	Cypridina-luciferin 2-monooxygenase activity	Losses
DI3	GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
DI3	GO:0070853	myosin VI binding	Losses
DI3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Losses
DI3	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Losses
DI3	GO:0003676	nucleic acid binding	Losses
DI3	GO:0017022	myosin binding	Losses
DI3	GO:0004687	myosin light chain kinase activity	Extinctions
DI3	GO:0003964	RNA-directed DNA polymerase activity	Extinctions
DI3	GO:0008270	zinc ion binding	Extinctions
DI3	GO:0003677	DNA binding	Extinctions
DI3	GO:0015412	ATPase-coupled molybdate transmembrane transporter activity	Extinctions
DI3	GO:0008986	pyruvate, water dikinase activity	Extinctions
DI3	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Extinctions
DI3	GO:0043998	H2A histone acetyltransferase activity	Extinctions
DI3	GO:0033904	dextranase activity	Extinctions
DI3	GO:0015098	molybdate ion transmembrane transporter activity	Extinctions
DI3	GO:0016622	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor	Extinctions
DI3	GO:0008805	carbon-monoxide oxygenase activity	Extinctions
DI3	GO:0034061	DNA polymerase activity	Extinctions
DI3	GO:0046914	transition metal ion binding	Extinctions
DI3	GO:0004852	uroporphyrinogen-III synthase activity	Extinctions
DI3	GO:0047712	Cypridina-luciferin 2-monooxygenase activity	Extinctions
DI3	GO:0003712	transcription cofactor activity	Extinctions
DI3	GO:0004792	thiosulfate sulfurtransferase activity	Extinctions
DI3	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Extinctions
DI3	GO:0030798	trans-aconitate 2-methyltransferase activity	Extinctions
DI3	GO:0016781	phosphotransferase activity, paired acceptors	Extinctions
DI3	GO:0043394	proteoglycan binding	Extinctions
DI3	GO:0043395	heparan sulfate proteoglycan binding	Extinctions
DI3	GO:0032794	GTPase activating protein binding	Extinctions
DI3	GO:0015171	amino acid transmembrane transporter activity	Extinctions