EOG803061 GO:0006511 31/105 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG803061 GO:0008234 26/105 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG803061 GO:0016579 1/105 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG803061 GO:0035328 1/105 transcriptionally silent chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872] EOG803061 GO:0008233 1/105 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG803061 GO:0005634 1/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG803061 GO:0016578 1/105 histone deubiquitination biological_process "The modification of histones by removal of ubiquitin groups." [GOC:ai] EOG803061 GO:0006342 1/105 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG803061 GO:0005700 1/105 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG803061 GO:0043234 1/105 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG803061 GO:0004843 1/105 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]