EOG89PDDD GO:1901837 1/81 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript from RNA polymerase I promoter." [GOC:sart, GOC:TermGenie] EOG89PDDD GO:1901840 1/81 negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie] EOG89PDDD GO:0005737 1/81 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89PDDD GO:0005730 1/81 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG89PDDD GO:0030718 1/81 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]