EOG8B8MWT GO:0008270 25/101 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B8MWT GO:0004402 24/101 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8B8MWT GO:0006355 23/101 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8B8MWT GO:0003713 20/101 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8B8MWT GO:0005634 18/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8B8MWT GO:0000123 6/101 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8B8MWT GO:0003712 5/101 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8B8MWT GO:0008140 1/101 cAMP response element binding protein binding molecular_function "Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah] EOG8B8MWT GO:0040040 1/101 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8B8MWT GO:0007088 1/101 regulation of mitotic nuclear division biological_process "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8B8MWT GO:0043982 1/101 histone H4-K8 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl] EOG8B8MWT GO:0016592 1/101 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8B8MWT GO:0016849 1/101 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8B8MWT GO:0043993 1/101 histone acetyltransferase activity (H3-K18 specific) molecular_function "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48] EOG8B8MWT GO:0001745 1/101 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8B8MWT GO:0016021 1/101 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B8MWT GO:0008134 1/101 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8B8MWT GO:0043983 1/101 histone H4-K12 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] EOG8B8MWT GO:0043234 1/101 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8B8MWT GO:0016055 1/101 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8B8MWT GO:0045475 1/101 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8B8MWT GO:0032922 1/101 circadian regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] EOG8B8MWT GO:0035556 1/101 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8B8MWT GO:0007224 1/101 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG8B8MWT GO:0007416 1/101 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8B8MWT GO:0001104 1/101 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8B8MWT GO:0043974 1/101 histone H3-K27 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl] EOG8B8MWT GO:0007269 1/101 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8B8MWT GO:0045466 1/101 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG8B8MWT GO:0022008 1/101 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8B8MWT GO:0045944 1/101 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8B8MWT GO:0000076 1/101 DNA replication checkpoint biological_process "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] EOG8B8MWT GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8B8MWT GO:0043971 1/101 histone H3-K18 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl] EOG8B8MWT GO:0009190 1/101 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8B8MWT GO:0000166 1/101 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8B8MWT GO:0048749 1/101 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8B8MWT GO:0030097 1/101 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8B8MWT GO:0007464 1/101 R3/R4 cell fate commitment biological_process "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG8B8MWT GO:0044017 1/101 histone acetyltransferase activity (H3-K27 specific) molecular_function "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48] EOG8B8MWT GO:0008347 1/101 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]