EOG8CC6G6 GO:0005634 11/12 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6G6 GO:0043565 11/12 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CC6G6 GO:0003700 10/12 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CC6G6 GO:0006351 10/12 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8CC6G6 GO:0005667 1/12 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8CC6G6 GO:0009888 1/12 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8CC6G6 GO:0051090 1/12 regulation of sequence-specific DNA binding transcription factor activity biological_process "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] EOG8CC6G6 GO:0003690 1/12 double-stranded DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] EOG8CC6G6 GO:0000122 1/12 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8CC6G6 GO:0008134 1/12 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8CC6G6 GO:0007389 1/12 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8CC6G6 GO:0048806 1/12 genitalia development biological_process "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] EOG8CC6G6 GO:0008301 1/12 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG8CC6G6 GO:0006366 1/12 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8CC6G6 GO:0003705 1/12 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]