EOG8GMXB8 GO:0005634 25/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GMXB8 GO:0003677 25/93 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GMXB8 GO:0006352 25/93 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG8GMXB8 GO:0016570 24/93 histone modification biological_process "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] EOG8GMXB8 GO:0045893 1/93 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GMXB8 GO:0051571 1/93 positive regulation of histone H3-K4 methylation biological_process "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] EOG8GMXB8 GO:0035327 1/93 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8GMXB8 GO:0007219 1/93 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8GMXB8 GO:0042800 1/93 histone methyltransferase activity (H3-K4 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] EOG8GMXB8 GO:0045747 1/93 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8GMXB8 GO:0005654 1/93 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8GMXB8 GO:0051568 1/93 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]