EOG8S7N3S GO:0003677 27/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8S7N3S GO:0003899 27/99 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8S7N3S GO:0005665 26/99 DNA-directed RNA polymerase II, core complex cellular_component "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8S7N3S GO:0006366 26/99 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8S7N3S GO:0005700 1/99 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8S7N3S GO:0006351 1/99 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8S7N3S GO:0007095 1/99 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8S7N3S GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S7N3S GO:0046872 1/99 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S7N3S GO:0005703 1/99 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]