GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0008066 glutamate receptor activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0022824 transmitter-gated ion channel activity Gains GO:0022835 transmitter-gated channel activity Gains GO:0004970 ionotropic glutamate receptor activity Gains GO:0005234 extracellularly glutamate-gated ion channel activity Gains GO:0005231 excitatory extracellular ligand-gated ion channel activity Gains GO:0099600 transmembrane receptor activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0022857 transmembrane transporter activity Gains GO:0008378 galactosyltransferase activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0005549 odorant binding Gains GO:0015075 ion transmembrane transporter activity Gains GO:0022836 gated channel activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0034061 DNA polymerase activity Gains GO:0005215 transporter activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0036081 extracellular ammonia-gated ion channel activity Gains GO:0022892 substrate-specific transporter activity Gains GO:0008061 chitin binding Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0035250 UDP-galactosyltransferase activity Gains GO:0038023 signaling receptor activity Gains GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0004872 receptor activity Gains GO:0008812 choline dehydrogenase activity Gains GO:0004984 olfactory receptor activity Gains GO:0060089 molecular transducer activity Gains GO:0017153 sodium:dicarboxylate symporter activity Gains GO:0008556 potassium-transporting ATPase activity Gains GO:0016798 hydrolase activity, acting on glycosyl bonds Gains GO:0004871 signal transducer activity Gains GO:0008527 taste receptor activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0004930 G-protein coupled receptor activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0004568 chitinase activity Gains GO:0042302 structural constituent of cuticle Gains GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Gains GO:0003700 DNA binding transcription factor activity Losses GO:0044212 transcription regulatory region DNA binding Losses GO:0001067 regulatory region nucleic acid binding Losses GO:0000975 regulatory region DNA binding Losses GO:0140110 transcription regulator activity Losses GO:0043565 sequence-specific DNA binding Losses GO:0000976 transcription regulatory region sequence-specific DNA binding Losses GO:1990837 sequence-specific double-stranded DNA binding Losses GO:0001012 RNA polymerase II regulatory region DNA binding Losses GO:0003690 double-stranded DNA binding Losses GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding Losses GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Losses GO:0004930 G-protein coupled receptor activity Losses GO:0003677 DNA binding Losses GO:1990939 ATP-dependent microtubule motor activity Losses GO:0004000 adenosine deaminase activity Losses GO:0003964 RNA-directed DNA polymerase activity Losses GO:0004872 receptor activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0004667 prostaglandin-D synthase activity Losses GO:0004097 catechol oxidase activity Losses GO:0004997 thyrotropin-releasing hormone receptor activity Losses GO:0042654 ecdysis-triggering hormone receptor activity Losses GO:0036263 L-DOPA monooxygenase activity Losses GO:0036264 dopamine monooxygenase activity Losses GO:0005436 sodium:phosphate symporter activity Losses GO:0038023 signaling receptor activity Losses GO:0070001 aspartic-type peptidase activity Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0060089 molecular transducer activity Losses GO:0001653 peptide receptor activity Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0019239 deaminase activity Losses GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Losses GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding Losses GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Losses GO:0008227 G-protein coupled amine receptor activity Losses GO:0003676 nucleic acid binding Losses GO:0004657 proline dehydrogenase activity Losses GO:0043425 bHLH transcription factor binding Losses GO:0001637 G-protein coupled chemoattractant receptor activity Losses GO:0004995 tachykinin receptor activity Losses GO:0004950 chemokine receptor activity Losses GO:0004972 NMDA glutamate receptor activity Losses GO:0016286 small conductance calcium-activated potassium channel activity Losses GO:0008422 beta-glucosidase activity Losses GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Losses GO:0005314 high-affinity glutamate transmembrane transporter activity Losses GO:0046423 allene-oxide cyclase activity Losses GO:0015321 sodium-dependent phosphate transmembrane transporter activity Losses GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity Losses GO:0005520 insulin-like growth factor binding Losses GO:0004503 monophenol monooxygenase activity Losses GO:0008061 chitin binding Losses GO:0099600 transmembrane receptor activity Losses GO:0034061 DNA polymerase activity Losses GO:0016849 phosphorus-oxygen lyase activity Losses GO:0009975 cyclase activity Losses GO:0019838 growth factor binding Losses GO:0009922 fatty acid elongase activity Losses GO:0004064 arylesterase activity Losses GO:0004348 glucosylceramidase activity Losses GO:0004896 cytokine receptor activity Losses GO:0052689 carboxylic ester hydrolase activity Losses GO:0004252 serine-type endopeptidase activity Novel expansions GO:0008236 serine-type peptidase activity Novel expansions GO:0017171 serine hydrolase activity Novel expansions GO:0004175 endopeptidase activity Novel expansions GO:0000976 transcription regulatory region sequence-specific DNA binding Extinctions GO:1990837 sequence-specific double-stranded DNA binding Extinctions GO:0044212 transcription regulatory region DNA binding Extinctions GO:0001067 regulatory region nucleic acid binding Extinctions GO:0000975 regulatory region DNA binding Extinctions GO:0003690 double-stranded DNA binding Extinctions GO:0001012 RNA polymerase II regulatory region DNA binding Extinctions GO:0140110 transcription regulator activity Extinctions GO:0004000 adenosine deaminase activity Extinctions GO:1990939 ATP-dependent microtubule motor activity Extinctions GO:0003700 DNA binding transcription factor activity Extinctions GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Extinctions GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Extinctions GO:0019239 deaminase activity Extinctions GO:0043565 sequence-specific DNA binding Extinctions GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Extinctions GO:0004657 proline dehydrogenase activity Extinctions GO:0016286 small conductance calcium-activated potassium channel activity Extinctions GO:0008422 beta-glucosidase activity Extinctions GO:0005520 insulin-like growth factor binding Extinctions GO:0019838 growth factor binding Extinctions GO:0004064 arylesterase activity Extinctions GO:0004348 glucosylceramidase activity Extinctions GO:0001965 G-protein alpha-subunit binding Extinctions GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor Extinctions GO:0004784 superoxide dismutase activity Extinctions GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed Extinctions GO:0004736 pyruvate carboxylase activity Extinctions GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed Extinctions GO:0019205 nucleobase-containing compound kinase activity Extinctions GO:0004930 G-protein coupled receptor activity Extinctions GO:0005267 potassium channel activity Extinctions GO:0015269 calcium-activated potassium channel activity Extinctions GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Extinctions