GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0016779 nucleotidyltransferase activity Gains GO:0003676 nucleic acid binding Gains GO:0070001 aspartic-type peptidase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0008270 zinc ion binding Gains GO:1901363 heterocyclic compound binding Gains GO:0097159 organic cyclic compound binding Gains GO:0004175 endopeptidase activity Gains GO:0046914 transition metal ion binding Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0022857 transmembrane transporter activity Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0004519 endonuclease activity Gains GO:0005549 odorant binding Gains GO:0008233 peptidase activity Gains GO:0003677 DNA binding Gains GO:0005249 voltage-gated potassium channel activity Gains GO:0046872 metal ion binding Gains GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Gains GO:0004518 nuclease activity Gains GO:0043169 cation binding Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0008324 cation transmembrane transporter activity Gains GO:0015077 monovalent inorganic cation transmembrane transporter activity Gains GO:0022843 voltage-gated cation channel activity Gains GO:0022890 inorganic cation transmembrane transporter activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0005267 potassium channel activity Gains GO:0008812 choline dehydrogenase activity Gains GO:0005452 inorganic anion exchanger activity Gains GO:0015079 potassium ion transmembrane transporter activity Gains GO:0015927 trehalase activity Gains GO:0004555 alpha,alpha-trehalase activity Gains GO:0005314 high-affinity glutamate transmembrane transporter activity Gains GO:0070548 L-glutamine aminotransferase activity Gains GO:0004457 lactate dehydrogenase activity Gains GO:0004723 calcium-dependent protein serine/threonine phosphatase activity Gains GO:0005215 transporter activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0022832 voltage-gated channel activity Gains GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Gains GO:0004984 olfactory receptor activity Gains GO:0042302 structural constituent of cuticle Gains GO:0022892 substrate-specific transporter activity Gains GO:0050660 flavin adenine dinucleotide binding Gains GO:0008236 serine-type peptidase activity Gains GO:0099600 transmembrane receptor activity Gains GO:0004075 biotin carboxylase activity Gains GO:0004016 adenylate cyclase activity Gains GO:0017171 serine hydrolase activity Gains GO:0004594 pantothenate kinase activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0004521 endoribonuclease activity Gains GO:0046933 proton-transporting ATP synthase activity, rotational mechanism Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0004198 calcium-dependent cysteine-type endopeptidase activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0005215 transporter activity Losses GO:0042625 ATPase coupled ion transmembrane transporter activity Losses GO:0050254 rhodopsin kinase activity Losses GO:0043492 ATPase activity, coupled to movement of substances Losses GO:0042626 ATPase activity, coupled to transmembrane movement of substances Losses GO:0015416 ATPase-coupled organic phosphonate transmembrane transporter activity Losses GO:0015604 organic phosphonate transmembrane transporter activity Losses GO:0015399 primary active transmembrane transporter activity Losses GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity Losses GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Losses GO:0022857 transmembrane transporter activity Losses GO:0022853 active ion transmembrane transporter activity Losses GO:0043225 ATPase-coupled anion transmembrane transporter activity Losses GO:0008144 drug binding Losses GO:0035237 corazonin receptor activity Losses GO:0046790 virion binding Losses GO:0004598 peptidylamidoglycolate lyase activity Losses GO:0008908 isochorismatase activity Losses GO:0015175 neutral amino acid transmembrane transporter activity Losses GO:0004061 arylformamidase activity Losses GO:0050093 methanol dehydrogenase activity Losses GO:0072320 volume-sensitive chloride channel activity Losses GO:0019811 cocaine binding Losses GO:0015222 serotonin transmembrane transporter activity Losses GO:0070742 C2H2 zinc finger domain binding Losses GO:0005329 dopamine transmembrane transporter activity Losses GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Losses GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Losses GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity Losses GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Losses GO:0004392 heme oxygenase (decyclizing) activity Losses GO:0004359 glutaminase activity Losses GO:0004474 malate synthase activity Losses GO:0042071 leucokinin receptor activity Losses GO:0005225 volume-sensitive anion channel activity Losses GO:0042943 D-amino acid transmembrane transporter activity Losses GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Losses GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Losses GO:0008509 anion transmembrane transporter activity Losses GO:0015605 organophosphate ester transmembrane transporter activity Losses GO:0019829 cation-transporting ATPase activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0004983 neuropeptide Y receptor activity Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0022804 active transmembrane transporter activity Losses GO:0050591 quinine 3-monooxygenase activity Losses GO:0050699 WW domain binding Losses GO:0070405 ammonium ion binding Losses GO:0001094 TFIID-class transcription factor binding Losses GO:0070888 E-box binding Losses GO:0004371 glycerone kinase activity Losses GO:0004333 fumarate hydratase activity Losses GO:0097003 adipokinetic hormone receptor activity Losses GO:0097004 adipokinetic hormone binding Losses GO:0004140 dephospho-CoA kinase activity Losses GO:0033777 lithocholate 6beta-hydroxylase activity Losses GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Losses GO:0008504 monoamine transmembrane transporter activity Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0005549 odorant binding Novel expansions GO:0004252 serine-type endopeptidase activity Novel expansions GO:0008270 zinc ion binding Novel expansions GO:0008236 serine-type peptidase activity Novel expansions GO:0017171 serine hydrolase activity Novel expansions GO:0046914 transition metal ion binding Novel expansions GO:0005242 inward rectifier potassium channel activity Novel expansions GO:0008970 phosphatidylcholine 1-acylhydrolase activity Novel expansions GO:0099600 transmembrane receptor activity Novel expansions GO:0004930 G-protein coupled receptor activity Novel expansions GO:0019829 cation-transporting ATPase activity Extinctions GO:0008188 neuropeptide receptor activity Extinctions GO:0035237 corazonin receptor activity Extinctions GO:0008908 isochorismatase activity Extinctions GO:0004061 arylformamidase activity Extinctions GO:0050093 methanol dehydrogenase activity Extinctions GO:0070742 C2H2 zinc finger domain binding Extinctions GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Extinctions GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Extinctions GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity Extinctions GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Extinctions GO:0004392 heme oxygenase (decyclizing) activity Extinctions GO:0004359 glutaminase activity Extinctions GO:0042071 leucokinin receptor activity Extinctions GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Extinctions GO:0043492 ATPase activity, coupled to movement of substances Extinctions GO:0042626 ATPase activity, coupled to transmembrane movement of substances Extinctions GO:0042625 ATPase coupled ion transmembrane transporter activity Extinctions GO:0004983 neuropeptide Y receptor activity Extinctions GO:0015399 primary active transmembrane transporter activity Extinctions GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity Extinctions GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Extinctions GO:0008528 G-protein coupled peptide receptor activity Extinctions GO:0001653 peptide receptor activity Extinctions GO:0005215 transporter activity Extinctions GO:0046961 proton-transporting ATPase activity, rotational mechanism Extinctions GO:0022853 active ion transmembrane transporter activity Extinctions GO:0050254 rhodopsin kinase activity Extinctions GO:0001094 TFIID-class transcription factor binding Extinctions GO:0004371 glycerone kinase activity Extinctions GO:0004333 fumarate hydratase activity Extinctions GO:0097003 adipokinetic hormone receptor activity Extinctions GO:0097004 adipokinetic hormone binding Extinctions GO:0004140 dephospho-CoA kinase activity Extinctions GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Extinctions GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism Extinctions