GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0042834	peptidoglycan binding	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004872	receptor activity	Gains
GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0099094	ligand-gated cation channel activity	Gains
GO:0005550	pheromone binding	Gains
GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
GO:0005549	odorant binding	Gains
GO:0022836	gated channel activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0016803	ether hydrolase activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0005214	structural constituent of chitin-based cuticle	Gains
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0005539	glycosaminoglycan binding	Gains
GO:0071855	neuropeptide receptor binding	Gains
GO:0046914	transition metal ion binding	Gains
GO:0003707	steroid hormone receptor activity	Gains
GO:0016801	hydrolase activity, acting on ether bonds	Gains
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	Gains
GO:0016211	ammonia ligase activity	Gains
GO:0045735	nutrient reservoir activity	Gains
GO:0008515	sucrose transmembrane transporter activity	Gains
GO:0050897	cobalt ion binding	Gains
GO:0044736	acid-sensing ion channel activity	Gains
GO:0016815	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	Gains
GO:0035274	diphenyl phthalate binding	Gains
GO:0035275	dibutyl phthalate binding	Gains
GO:0000257	nitrilase activity	Gains
GO:0035237	corazonin receptor activity	Gains
GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	Gains
GO:0004556	alpha-amylase activity	Gains
GO:0001875	lipopolysaccharide receptor activity	Gains
GO:0042165	neurotransmitter binding	Gains
GO:0042166	acetylcholine binding	Gains
GO:0036132	13-prostaglandin reductase activity	Gains
GO:0015322	secondary active oligopeptide transmembrane transporter activity	Gains
GO:0032454	histone demethylase activity (H3-K9 specific)	Gains
GO:0016019	peptidoglycan receptor activity	Gains
GO:0004060	arylamine N-acetyltransferase activity	Gains
GO:0004059	aralkylamine N-acetyltransferase activity	Gains
GO:0071859	neuropeptide F receptor binding	Gains
GO:0004037	allantoicase activity	Gains
GO:0004038	allantoinase activity	Gains
GO:0004971	AMPA glutamate receptor activity	Gains
GO:0008459	chondroitin 6-sulfotransferase activity	Gains
GO:0015280	ligand-gated sodium channel activity	Gains
GO:0070576	vitamin D 24-hydroxylase activity	Gains
GO:0050309	sugar-terminal-phosphatase activity	Gains
GO:0004356	glutamate-ammonia ligase activity	Gains
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Gains
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity	Gains
GO:0004346	glucose-6-phosphatase activity	Gains
GO:0004301	epoxide hydrolase activity	Gains
GO:0016160	amylase activity	Gains
GO:0050112	inositol 2-dehydrogenase activity	Gains
GO:0032500	muramyl dipeptide binding	Gains
GO:0061783	peptidoglycan muralytic activity	Gains
GO:0005215	transporter activity	Gains
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0004180	carboxypeptidase activity	Gains
GO:0008270	zinc ion binding	Gains
GO:0008146	sulfotransferase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004497	monooxygenase activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0043169	cation binding	Losses
GO:0003676	nucleic acid binding	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0003677	DNA binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0098988	G-protein coupled glutamate receptor activity	Losses
GO:0015927	trehalase activity	Losses
GO:0004555	alpha,alpha-trehalase activity	Losses
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Losses
GO:0001641	group II metabotropic glutamate receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0004803	transposase activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0043167	ion binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	Losses
GO:0004322	ferroxidase activity	Losses
GO:0004518	nuclease activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0008066	glutamate receptor activity	Losses
GO:0004872	receptor activity	Losses
GO:0140104	molecular carrier activity	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0032934	sterol binding	Novel expansions
GO:0005496	steroid binding	Novel expansions
GO:0097159	organic cyclic compound binding	Novel expansions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0043169	cation binding	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0098988	G-protein coupled glutamate receptor activity	Extinctions
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	Extinctions
GO:0001641	group II metabotropic glutamate receptor activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0004803	transposase activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0140104	molecular carrier activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
GO:0008816	citryl-CoA lyase activity	Extinctions
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
GO:0008531	riboflavin kinase activity	Extinctions
GO:0016595	glutamate binding	Extinctions
GO:0031177	phosphopantetheine binding	Extinctions
GO:0003920	GMP reductase activity	Extinctions
GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
GO:0051032	nucleic acid transmembrane transporter activity	Extinctions
GO:0051033	RNA transmembrane transporter activity	Extinctions
GO:0001642	group III metabotropic glutamate receptor activity	Extinctions
GO:0035650	AP-1 adaptor complex binding	Extinctions
GO:0000036	acyl carrier activity	Extinctions
GO:0051192	prosthetic group binding	Extinctions
GO:0003720	telomerase activity	Extinctions
GO:0003721	telomerase RNA reverse transcriptase activity	Extinctions
GO:0008528	G-protein coupled peptide receptor activity	Extinctions