GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0004930 G-protein coupled receptor activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0038023 signaling receptor activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0099600 transmembrane receptor activity Gains GO:0004871 signal transducer activity Gains GO:0004872 receptor activity Gains GO:0004965 G-protein coupled GABA receptor activity Gains GO:0008233 peptidase activity Gains GO:0020037 heme binding Gains GO:0046906 tetrapyrrole binding Gains GO:0005549 odorant binding Gains GO:0048018 receptor ligand activity Gains GO:0004497 monooxygenase activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0016917 GABA receptor activity Gains GO:0004000 adenosine deaminase activity Gains GO:0060089 molecular transducer activity Gains GO:0004175 endopeptidase activity Gains GO:0005506 iron ion binding Gains GO:0046914 transition metal ion binding Gains GO:0030545 receptor regulator activity Gains GO:0016209 antioxidant activity Gains GO:0018392 glycoprotein 3-alpha-L-fucosyltransferase activity Gains GO:0018445 prothoracicotrophic hormone activity Gains GO:0004634 phosphopyruvate hydratase activity Gains GO:0001642 group III metabotropic glutamate receptor activity Gains GO:0004054 arginine kinase activity Gains GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity Gains GO:0015250 water channel activity Gains GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Gains GO:0052722 fatty acid in-chain hydroxylase activity Gains GO:0071837 HMG box domain binding Gains GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific Gains GO:0005372 water transmembrane transporter activity Gains GO:0046790 virion binding Gains GO:0004499 N,N-dimethylaniline monooxygenase activity Gains GO:0035274 diphenyl phthalate binding Gains GO:0035275 dibutyl phthalate binding Gains GO:0005122 torso binding Gains GO:0016595 glutamate binding Gains GO:0001106 RNA polymerase II transcription corepressor activity Gains GO:0071906 CRD domain binding Gains GO:0033932 1,3-alpha-L-fucosidase activity Gains GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Gains GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Gains GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Gains GO:0070491 repressing transcription factor binding Gains GO:0019239 deaminase activity Gains GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Gains GO:0005550 pheromone binding Gains GO:0004560 alpha-L-fucosidase activity Gains GO:0004555 alpha,alpha-trehalase activity Gains GO:0046920 alpha-(1->3)-fucosyltransferase activity Gains GO:0008011 structural constituent of pupal chitin-based cuticle Gains GO:0015459 potassium channel regulator activity Gains GO:0015485 cholesterol binding Gains GO:0019202 amino acid kinase activity Gains GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Gains GO:0001641 group II metabotropic glutamate receptor activity Gains GO:0050591 quinine 3-monooxygenase activity Gains GO:0033777 lithocholate 6beta-hydroxylase activity Gains GO:0005212 structural constituent of eye lens Gains GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding Gains GO:0098988 G-protein coupled glutamate receptor activity Gains GO:0001103 RNA polymerase II repressing transcription factor binding Gains GO:0015927 trehalase activity Gains GO:0015928 fucosidase activity Gains GO:0004867 serine-type endopeptidase inhibitor activity Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0001104 RNA polymerase II transcription cofactor activity Gains GO:0004806 triglyceride lipase activity Gains GO:0003723 RNA binding Gains GO:0016491 oxidoreductase activity Gains GO:0003677 DNA binding Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0042302 structural constituent of cuticle Losses GO:0019238 cyclohydrolase activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0005215 transporter activity Losses GO:0016411 acylglycerol O-acyltransferase activity Losses GO:0004844 uracil DNA N-glycosylase activity Losses GO:0005537 mannose binding Losses GO:0003943 N-acetylgalactosamine-4-sulfatase activity Losses GO:0004666 prostaglandin-endoperoxide synthase activity Losses GO:0019153 protein-disulfide reductase (glutathione) activity Losses GO:0009032 thymidine phosphorylase activity Losses GO:0008022 protein C-terminus binding Losses GO:0045294 alpha-catenin binding Losses GO:0097506 deaminated base DNA N-glycosylase activity Losses GO:0015145 monosaccharide transmembrane transporter activity Losses GO:0015149 hexose transmembrane transporter activity Losses GO:0030023 extracellular matrix constituent conferring elasticity Losses GO:0008458 carnitine O-octanoyltransferase activity Losses GO:0042301 phosphate ion binding Losses GO:0016414 O-octanoyltransferase activity Losses GO:0004372 glycine hydroxymethyltransferase activity Losses GO:0004324 ferredoxin-NADP+ reductase activity Losses GO:0004329 formate-tetrahydrofolate ligase activity Losses GO:0016154 pyrimidine-nucleoside phosphorylase activity Losses GO:0015578 mannose transmembrane transporter activity Losses GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity Losses GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Losses GO:0004477 methenyltetrahydrofolate cyclohydrolase activity Losses GO:0035236 proctolin receptor activity Losses GO:0004170 dUTP diphosphatase activity Losses GO:0097493 structural molecule activity conferring elasticity Losses GO:0008810 cellulase activity Losses GO:0016524 latrotoxin receptor activity Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0016684 oxidoreductase activity, acting on peroxide as acceptor Losses GO:0004601 peroxidase activity Losses GO:0008374 O-acyltransferase activity Losses GO:0001653 peptide receptor activity Losses GO:0001871 pattern binding Losses GO:0030247 polysaccharide binding Losses GO:0099600 transmembrane receptor activity Losses GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Novel expansions GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Novel expansions GO:0042302 structural constituent of cuticle Extinctions GO:0016684 oxidoreductase activity, acting on peroxide as acceptor Extinctions GO:0004601 peroxidase activity Extinctions GO:0004844 uracil DNA N-glycosylase activity Extinctions GO:0005537 mannose binding Extinctions GO:0004666 prostaglandin-endoperoxide synthase activity Extinctions GO:0019153 protein-disulfide reductase (glutathione) activity Extinctions GO:0009032 thymidine phosphorylase activity Extinctions GO:0008022 protein C-terminus binding Extinctions GO:0097506 deaminated base DNA N-glycosylase activity Extinctions GO:0015145 monosaccharide transmembrane transporter activity Extinctions GO:0015149 hexose transmembrane transporter activity Extinctions GO:0008458 carnitine O-octanoyltransferase activity Extinctions GO:0016414 O-octanoyltransferase activity Extinctions GO:0016154 pyrimidine-nucleoside phosphorylase activity Extinctions GO:0015578 mannose transmembrane transporter activity Extinctions GO:0035236 proctolin receptor activity Extinctions GO:0004170 dUTP diphosphatase activity Extinctions GO:0008810 cellulase activity Extinctions GO:0001871 pattern binding Extinctions GO:0030247 polysaccharide binding Extinctions GO:0016209 antioxidant activity Extinctions GO:0008188 neuropeptide receptor activity Extinctions GO:0000210 NAD+ diphosphatase activity Extinctions GO:0003933 GTP cyclohydrolase activity Extinctions GO:0003934 GTP cyclohydrolase I activity Extinctions GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Extinctions GO:0016415 octanoyltransferase activity Extinctions GO:0008890 glycine C-acetyltransferase activity Extinctions GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity Extinctions GO:0004797 thymidine kinase activity Extinctions