Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF01431 0 1 0 0 0 0 PF01433 0 1 0 0 0 0 PF01585 PF00035 1 0 0 0 0 0 PF01593 0 1 0 0 0 0 PF01608 0 1 0 0 0 0 PF01624 0 0 3 0 0 0 PF01756 0 0 5 0 0 0 PF01798 0 0 2 0 0 0 PF01822 0 0 2 0 0 0 PF01846 0 1 0 0 0 0 PF01926 0 1 0 0 0 0 PF02055 0 0 1 0 0 0 PF02171 0 0 5 0 0 0 PF02185 0 1 0 0 0 0 PF02205 0 0 2 0 0 0 PF02210 0 1 0 0 0 0 PF02210 PF00008 1 0 0 0 0 0 PF02212 0 1 3 0 0 0 PF02366 PF02815 0 0 1 0 0 0 PF02492 0 0 1 0 0 0 PF02668 0 0 1 0 0 0 PF02733 0 0 1 0 0 0 PF02738 0 0 5 0 0 0 PF02771 0 0 3 0 0 0 PF02779 0 0 1 0 0 0 PF02803 0 1 0 0 0 0 PF02820 0 1 5 0 0 0 PF02888 0 0 2 0 0 0 PF02892 PF04937 1 0 0 0 0 0 PF02898 0 1 0 0 0 0 PF02906 0 0 1 0 0 0 PF02934 0 0 1 0 0 0 PF02984 0 1 0 0 0 0 PF03009 0 1 0 0 0 0 PF03016 0 1 0 0 0 0 PF03177 0 1 0 0 0 0 PF03178 0 1 0 0 0 0 PF03351 0 1 0 0 0 0 PF03441 0 1 0 0 0 0 PF03446 0 1 0 0 0 0 PF03450 PF01315 PF02738 0 1 0 0 0 0 PF03473 0 0 3 0 0 0 PF03727 0 0 1 0 0 0 PF03834 0 0 1 0 0 0 PF04161 0 0 0 0 1 0 PF04379 0 1 0 0 0 0 PF04408 0 1 0 0 0 0 PF04408 PF07717 0 1 3 0 0 0 PF04433 0 1 0 0 0 0 PF04564 0 1 0 0 0 0 PF04757 PF00097 1 0 0 0 0 0 PF04818 0 1 0 0 0 0 PF04851 0 1 0 0 0 0 PF04950 0 0 1 0 0 0 PF04959 0 1 0 0 0 0 PF04997 PF00623 PF04983 0 0 2 0 0 0 PF05131 0 1 0 0 0 0 PF05193 0 1 0 0 0 0 PF05225 PF03221 1 0 0 0 0 0 PF05361 0 0 0 0 1 0 PF05470 0 1 0 0 0 0 PF05536 0 1 0 0 0 0 PF05605 0 0 1 0 0 0 PF05649 0 1 0 0 0 0 PF05916 0 1 0 0 0 0 PF06424 PF14559 PF13432 1 0 0 0 0 0 PF06466 0 0 2 0 0 0 PF06482 0 1 0 0 0 0 PF06652 0 1 0 0 0 0 PF06732 0 1 0 0 0 0 PF06733 0 1 2 0 0 0 PF07524 0 1 1 0 0 0 PF07527 0 1 0 0 0 0 PF07647 PF00536 1 0 0 0 0 0 PF07648 PF13927 1 0 0 0 0 0 PF07651 0 1 0 0 0 0 PF07653 PF00621 1 0 0 0 0 0 PF07679 PF00041 PF00069 1 0 0 0 0 0 PF07707 0 1 0 0 0 0 PF07714 PF00211 1 0 0 0 0 0 PF07717 0 1 7 0 0 0 PF07732 0 0 3 0 0 0 PF07743 0 1 0 0 0 0 PF07774 0 1 0 0 0 0 PF07859 0 0 1 0 0 0 PF08146 0 1 0 0 0 0 PF08232 0 1 0 0 0 0 PF08311 0 1 0 0 0 0 PF08336 0 1 0 0 0 0 PF08393 0 1 13 0 0 0 PF08393 PF12774 0 1 11 0 0 0 PF08393 PF12774 PF07728 PF12775 PF12780 PF12777 0 1 0 0 0 0 PF08397 PF14604 1 0 0 0 0 0 PF08412 0 1 0 0 0 0 PF08490 0 0 2 0 0 0 PF08544 0 1 2 0 0 0 PF08701 0 1 0 0 0 0 PF08755 0 1 0 0 0 0 PF08772 0 0 1 0 0 0 PF08801 0 1 0 0 0 0 PF08953 PF00400 0 0 1 0 0 0 PF09258 0 1 0 0 0 0 PF09332 0 0 1 0 0 0 PF09379 PF00373 1 0 6 0 0 0 PF09416 0 0 3 0 0 0 PF09431 0 1 0 0 0 0 PF09744 0 1 1 0 0 0 PF09750 0 0 1 0 0 0 PF09763 0 0 1 0 0 0 PF09778 0 0 0 0 1 0 PF10166 0 0 0 0 1 0 PF10291 0 1 0 0 0 0 PF10312 0 0 1 0 0 0 PF10358 0 0 2 0 0 0 PF10374 PF10373 0 1 0 0 0 0 PF10408 0 1 0 0 0 0 PF10433 0 1 0 0 0 0 PF10475 0 0 2 0 0 0 PF10517 0 1 0 0 0 0 PF10595 0 0 0 0 1 0 PF10602 0 1 0 0 0 0 PF11265 0 0 1 0 0 0 PF11461 0 1 0 0 0 0 PF11816 0 1 0 0 0 0 PF11838 0 1 0 0 0 0 PF12012 0 0 1 0 0 0 PF12066 0 1 0 0 0 0 PF12257 0 1 0 0 0 0 PF12341 0 1 0 0 0 0 PF12397 0 1 0 0 0 0 PF12409 0 0 6 0 0 0 PF12430 0 0 1 0 0 0 PF12455 0 1 0 0 0 0 PF12529 0 0 2 0 0 0 PF12569 0 1 0 0 0 0 PF12624 PF16908 0 0 3 0 0 0 PF12774 PF12775 PF12780 PF12777 PF12781 PF03028 0 1 0 0 0 0 PF12775 0 0 4 0 0 0 PF12775 PF12780 PF12777 PF12781 PF03028 0 1 0 0 0 0 PF12777 PF12781 0 0 5 0 0 0 PF12781 PF03028 0 1 0 0 0 0 PF12796 PF00023 0 1 0 0 0 0 PF12874 0 1 0 0 0 0 PF12999 0 0 1 0 0 0 PF13181 0 1 0 0 0 0 PF13242 0 1 0 0 0 0 PF13307 0 1 0 0 0 0 PF13344 0 1 0 0 0 0 PF13360 0 1 0 0 0 0 PF13378 0 0 1 0 0 0 PF13419 0 1 0 0 0 0 PF13424 PF13181 1 0 0 0 0 0 PF13606 0 1 0 0 0 0 PF13606 PF12796 0 1 0 0 0 0 PF13638 0 1 3 0 0 0 PF13638 PF17216 0 0 2 0 0 0 PF13639 0 1 0 0 0 0 PF13640 0 1 0 0 0 0 PF13705 0 1 0 0 0 0 PF13716 0 1 0 0 0 0 PF13793 0 0 1 0 0 0 PF13832 0 0 6 0 0 0 PF13843 PF03184 1 0 0 0 0 0 PF13848 0 1 0 0 0 0 PF13848 PF00085 0 1 0 0 0 0 PF13880 0 0 1 0 0 0 PF13894 PF12874 1 0 0 0 0 0 PF13912 PF12874 PF00096 PF13912 1 0 0 0 0 0 PF13919 0 0 1 0 0 0 PF13925 0 1 0 0 0 0 PF14204 0 0 1 0 0 0 PF14222 0 0 1 0 0 0 PF14382 0 1 1 0 0 0 PF14500 0 0 1 0 0 0 PF14529 PF00075 1 0 0 0 0 0 PF14538 0 0 2 0 0 0 PF14551 PF17207 0 1 0 0 0 0 PF14702 PF06202 0 0 2 0 0 0 PF14749 0 0 2 0 0 0 PF14838 0 0 1 0 0 0 PF14933 0 0 0 0 1 0 PF15409 0 1 0 0 0 0 PF15742 0 0 0 0 1 0 PF15749 0 0 0 0 1 0 PF15985 0 1 0 0 0 0 PF16034 0 0 0 0 1 0 PF16184 0 1 0 0 0 0 PF16209 0 1 0 0 0 0 PF16212 0 0 4 0 0 0 PF16501 0 1 0 0 0 0 PF16566 0 1 0 0 0 0 PF16589 0 1 0 0 0 0 PF16922 0 1 0 0 0 0 PF17207 0 1 0 0 0 0 PF00002 0 1 0 0 0 0 PF00010 0 1 0 0 0 0 PF00014 PF02210 1 0 0 0 0 0 PF00017 PF00018 1 0 0 0 0 0 PF00018 0 2 0 0 0 0 PF00023 0 1 0 0 0 0 PF00038 0 0 1 0 0 0 PF00045 0 1 2 0 0 0 PF00046 PF03798 1 0 0 0 0 0 PF00047 PF13927 1 0 0 0 0 0 PF00054 PF02210 1 0 2 0 0 0 PF00069 0 1 0 0 0 0 PF00069 PF00433 0 1 0 0 0 0 PF00076 PF11764 PF00856 1 0 0 0 0 0 PF00085 0 2 0 0 0 0 PF00089 PF00057 1 0 0 0 0 0 PF00096 PF12874 PF13912 1 0 0 0 0 0 PF00108 0 1 2 0 0 0 PF00111 PF01799 PF00941 0 1 0 0 0 0 PF00122 0 1 0 0 0 0 PF00132 0 1 0 0 0 0 PF00134 0 1 0 0 0 0 PF00176 0 1 0 0 0 0 PF00181 0 0 1 0 0 0 PF00226 0 1 0 0 0 0 PF00258 0 1 0 0 0 0 PF00258 PF00667 PF00175 0 1 0 0 0 0 PF00271 0 4 0 0 0 0 PF00271 PF04408 0 1 0 0 0 0 PF00288 0 1 0 0 0 0 PF00333 0 0 1 0 0 0 PF00350 PF01031 0 1 0 0 0 0 PF00382 0 0 2 0 0 0 PF00385 PF00176 PF00271 1 0 1 0 0 0 PF00393 0 1 0 0 0 0 PF00397 0 2 0 0 0 0 PF00397 PF00632 1 0 0 0 0 0 PF00400 0 4 0 0 0 0 PF00413 0 1 0 0 0 0 PF00454 PF02260 1 0 0 0 0 0 PF00483 0 1 0 0 0 0 PF00488 0 0 8 0 0 0 PF00493 0 2 0 0 0 0 PF00520 PF00027 0 1 0 0 0 0 PF00530 0 0 3 0 0 0 PF00536 0 1 0 0 0 0 PF00610 0 1 0 0 0 0 PF00611 0 1 0 0 0 0 PF00616 0 1 0 0 0 0 PF00617 0 1 0 0 0 0 PF00618 0 1 3 0 0 0 PF00620 0 1 0 0 0 0 PF00621 PF00018 1 0 0 0 0 0 PF00622 PF10607 1 0 0 0 0 0 PF00628 0 1 0 0 0 0 PF00628 PF00439 1 0 0 0 0 0 PF00628 PF14061 1 0 0 0 0 0 PF00637 0 1 0 0 0 0 PF00639 0 1 0 0 0 0 PF00648 0 1 0 0 0 0 PF00667 PF00175 0 1 0 0 0 0 PF00675 0 1 5 0 0 0 PF00686 0 1 0 0 0 0 PF00689 0 0 6 0 0 0 PF00757 PF01030 PF14843 PF07714 0 1 0 0 0 0 PF00784 0 1 0 0 0 0 PF00787 PF00069 1 0 0 0 0 0 PF00790 0 1 5 0 0 0 PF00791 0 0 2 0 0 0 PF00852 0 0 1 0 0 0 PF00867 0 0 1 0 0 0 PF00868 0 0 2 0 0 0 PF00875 0 1 0 0 0 0 PF00890 0 0 1 0 0 0 PF00940 0 0 1 0 0 0 PF01030 0 1 0 0 0 0 PF01067 0 1 0 0 0 0 PF01120 0 0 1 0 0 0 PF01210 0 0 1 0 0 0 PF01237 0 1 0 0 0 0 PF01302 0 1 0 0 0 0 PF01321 PF16189 PF00557 0 0 1 0 0 0 PF01326 0 0 2 0 0 0 PF01344 0 1 0 0 0 0 PF01391 0 1 0 0 0 0 PF01399 0 2 0 0 0 0