GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0005261 cation channel activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0099600 transmembrane receptor activity Gains GO:0005509 calcium ion binding Gains GO:0022836 gated channel activity Gains GO:0008324 cation transmembrane transporter activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0022890 inorganic cation transmembrane transporter activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0022892 substrate-specific transporter activity Gains GO:0005215 transporter activity Gains GO:0022857 transmembrane transporter activity Gains GO:0004714 transmembrane receptor protein tyrosine kinase activity Gains GO:0022832 voltage-gated channel activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0019199 transmembrane receptor protein kinase activity Gains GO:0072509 divalent inorganic cation transmembrane transporter activity Gains GO:0038023 signaling receptor activity Gains GO:0003779 actin binding Gains GO:0004872 receptor activity Gains GO:0015085 calcium ion transmembrane transporter activity Gains GO:0004871 signal transducer activity Gains GO:0005201 extracellular matrix structural constituent Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0060089 molecular transducer activity Gains GO:0005262 calcium channel activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors Gains GO:0005310 dicarboxylic acid transmembrane transporter activity Gains GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Gains GO:0022843 voltage-gated cation channel activity Gains GO:0004972 NMDA glutamate receptor activity Gains GO:0019992 diacylglycerol binding Gains GO:0047134 protein-disulfide reductase activity Gains GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Gains GO:0005267 potassium channel activity Gains GO:0008061 chitin binding Gains GO:0008092 cytoskeletal protein binding Gains GO:0032440 2-alkenal reductase [NAD(P)] activity Gains GO:0005231 excitatory extracellular ligand-gated ion channel activity Gains GO:0004713 protein tyrosine kinase activity Gains GO:0016453 C-acetyltransferase activity Gains GO:0004447 iodide peroxidase activity Gains GO:0005154 epidermal growth factor receptor binding Gains GO:0005248 voltage-gated sodium channel activity Gains GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential Gains GO:0030898 actin-dependent ATPase activity Gains GO:0099094 ligand-gated cation channel activity Gains GO:0016491 oxidoreductase activity Gains GO:0005249 voltage-gated potassium channel activity Gains GO:0015079 potassium ion transmembrane transporter activity Gains GO:0005088 Ras guanyl-nucleotide exchange factor activity Gains GO:0005085 guanyl-nucleotide exchange factor activity Gains GO:0015556 C4-dicarboxylate transmembrane transporter activity Gains GO:0070851 growth factor receptor binding Gains GO:0005251 delayed rectifier potassium channel activity Gains GO:0017153 sodium:dicarboxylate symporter activity Gains GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Gains GO:0001786 phosphatidylserine binding Gains GO:0005516 calmodulin binding Gains GO:0005515 protein binding Gains GO:0005548 phospholipid transporter activity Gains GO:0042803 protein homodimerization activity Gains GO:0015077 monovalent inorganic cation transmembrane transporter activity Gains GO:0005342 organic acid transmembrane transporter activity Gains GO:0046943 carboxylic acid transmembrane transporter activity Gains GO:0005234 extracellularly glutamate-gated ion channel activity Gains GO:0008509 anion transmembrane transporter activity Gains GO:0072341 modified amino acid binding Gains GO:0005452 inorganic anion exchanger activity Gains GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Gains GO:0016500 protein-hormone receptor activity Gains GO:0008188 neuropeptide receptor activity Gains GO:0050839 cell adhesion molecule binding Gains GO:0003995 acyl-CoA dehydrogenase activity Gains GO:0016667 oxidoreductase activity, acting on a sulfur group of donors Gains GO:0042802 identical protein binding Gains GO:0098772 molecular function regulator Gains GO:0017016 Ras GTPase binding Gains GO:0016301 kinase activity Gains GO:0051020 GTPase binding Gains GO:0043169 cation binding Gains GO:0003774 motor activity Gains GO:0031267 small GTPase binding Gains GO:0008158 hedgehog receptor activity Gains GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity Gains GO:0008239 dipeptidyl-peptidase activity Gains GO:0008028 monocarboxylic acid transmembrane transporter activity Gains GO:0015081 sodium ion transmembrane transporter activity Gains GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Gains GO:0046872 metal ion binding Gains GO:0005089 Rho guanyl-nucleotide exchange factor activity Gains GO:0008514 organic anion transmembrane transporter activity Gains GO:0005179 hormone activity Losses GO:0048018 receptor ligand activity Losses GO:0030545 receptor regulator activity Losses GO:0005184 neuropeptide hormone activity Losses GO:0016849 phosphorus-oxygen lyase activity Losses GO:0018685 alkane 1-monooxygenase activity Losses GO:0003964 RNA-directed DNA polymerase activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0099600 transmembrane receptor activity Losses GO:0001664 G-protein coupled receptor binding Losses GO:0004312 fatty acid synthase activity Losses GO:0046914 transition metal ion binding Losses GO:0016530 metallochaperone activity Losses GO:0019238 cyclohydrolase activity Losses GO:0009922 fatty acid elongase activity Losses GO:0004518 nuclease activity Losses GO:0005102 receptor binding Losses GO:0009975 cyclase activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0004857 enzyme inhibitor activity Losses GO:0005506 iron ion binding Losses GO:0004129 cytochrome-c oxidase activity Losses GO:0015002 heme-copper terminal oxidase activity Losses GO:0016675 oxidoreductase activity, acting on a heme group of donors Losses GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor Losses GO:0004803 transposase activity Losses GO:0061134 peptidase regulator activity Losses GO:0004871 signal transducer activity Losses GO:0008241 peptidyl-dipeptidase activity Losses GO:0030291 protein serine/threonine kinase inhibitor activity Losses GO:0004526 ribonuclease P activity Losses GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Losses GO:0008066 glutamate receptor activity Losses GO:0038023 signaling receptor activity Losses GO:0030414 peptidase inhibitor activity Losses GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Losses GO:0005230 extracellular ligand-gated ion channel activity Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Losses GO:0070001 aspartic-type peptidase activity Losses GO:0004519 endonuclease activity Losses GO:0005179 hormone activity Extinctions GO:0005184 neuropeptide hormone activity Extinctions GO:0016849 phosphorus-oxygen lyase activity Extinctions GO:0004930 G-protein coupled receptor activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0048018 receptor ligand activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0038023 signaling receptor activity Extinctions GO:0030545 receptor regulator activity Extinctions GO:0009975 cyclase activity Extinctions GO:0004872 receptor activity Extinctions GO:0016530 metallochaperone activity Extinctions GO:0004129 cytochrome-c oxidase activity Extinctions GO:0015002 heme-copper terminal oxidase activity Extinctions GO:0016675 oxidoreductase activity, acting on a heme group of donors Extinctions GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor Extinctions GO:0060089 molecular transducer activity Extinctions GO:0005230 extracellular ligand-gated ion channel activity Extinctions GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Extinctions GO:0008066 glutamate receptor activity Extinctions GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Extinctions GO:0004526 ribonuclease P activity Extinctions GO:0004521 endoribonuclease activity Extinctions GO:0004540 ribonuclease activity Extinctions GO:0004871 signal transducer activity Extinctions GO:0005506 iron ion binding Extinctions GO:0008527 taste receptor activity Extinctions GO:0004549 tRNA-specific ribonuclease activity Extinctions GO:0061134 peptidase regulator activity Extinctions GO:0015276 ligand-gated ion channel activity Extinctions GO:0022834 ligand-gated channel activity Extinctions GO:0004970 ionotropic glutamate receptor activity Extinctions GO:0022824 transmitter-gated ion channel activity Extinctions GO:0022835 transmitter-gated channel activity Extinctions GO:0004383 guanylate cyclase activity Extinctions GO:0017147 Wnt-protein binding Extinctions GO:0004518 nuclease activity Extinctions