GO:0004736 pyruvate carboxylase activity Gains GO:0042302 structural constituent of cuticle Gains GO:0008010 structural constituent of chitin-based larval cuticle Gains GO:0017080 sodium channel regulator activity Gains GO:1990939 ATP-dependent microtubule motor activity Gains GO:0004075 biotin carboxylase activity Gains GO:0008417 fucosyltransferase activity Gains GO:0042826 histone deacetylase binding Gains GO:0052689 carboxylic ester hydrolase activity Gains GO:0005214 structural constituent of chitin-based cuticle Gains GO:0030414 peptidase inhibitor activity Gains GO:0031208 POZ domain binding Gains GO:0005215 transporter activity Gains GO:0004035 alkaline phosphatase activity Gains GO:0015928 fucosidase activity Gains GO:0005314 high-affinity glutamate transmembrane transporter activity Gains GO:0005199 structural constituent of cell wall Gains GO:0004560 alpha-L-fucosidase activity Gains GO:0046920 alpha-(1->3)-fucosyltransferase activity Gains GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Gains GO:0016885 ligase activity, forming carbon-carbon bonds Gains GO:0004104 cholinesterase activity Gains GO:0005227 calcium activated cation channel activity Gains GO:0061134 peptidase regulator activity Gains GO:0015294 solute:cation symporter activity Gains GO:0030246 carbohydrate binding Gains GO:0003777 microtubule motor activity Gains GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Gains GO:0016247 channel regulator activity Gains GO:0022839 ion gated channel activity Gains GO:0004519 endonuclease activity Gains GO:0016788 hydrolase activity, acting on ester bonds Gains GO:0005501 retinoid binding Gains GO:0004064 arylesterase activity Gains GO:0008336 gamma-butyrobetaine dioxygenase activity Gains GO:0008198 ferrous iron binding Gains GO:0004457 lactate dehydrogenase activity Gains GO:0046592 polyamine oxidase activity Gains GO:0015321 sodium-dependent phosphate transmembrane transporter activity Gains GO:0019136 deoxynucleoside kinase activity Gains GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed Gains GO:0003774 motor activity Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0019206 nucleoside kinase activity Gains GO:0022836 gated channel activity Gains GO:0004857 enzyme inhibitor activity Gains GO:0008233 peptidase activity Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0005319 lipid transporter activity Gains GO:0004866 endopeptidase inhibitor activity Gains GO:0015293 symporter activity Gains GO:0004252 serine-type endopeptidase activity Gains GO:0016886 ligase activity, forming phosphoric ester bonds Gains GO:0015296 anion:cation symporter activity Gains GO:0008146 sulfotransferase activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0016724 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor Gains GO:0004322 ferroxidase activity Gains GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Gains GO:1901677 phosphate transmembrane transporter activity Gains GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed Gains GO:0015114 phosphate ion transmembrane transporter activity Gains GO:0016782 transferase activity, transferring sulfur-containing groups Gains GO:0038024 cargo receptor activity Gains GO:0019901 protein kinase binding Gains GO:0015171 amino acid transmembrane transporter activity Gains GO:0017171 serine hydrolase activity Gains GO:0099600 transmembrane receptor activity Losses GO:0004872 receptor activity Losses GO:0038023 signaling receptor activity Losses GO:0060089 molecular transducer activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0004871 signal transducer activity Losses GO:0004040 amidase activity Losses GO:0033041 sweet taste receptor activity Losses GO:0005539 glycosaminoglycan binding Losses GO:0004857 enzyme inhibitor activity Losses GO:0030414 peptidase inhibitor activity Losses GO:0005216 ion channel activity Losses GO:0003823 antigen binding Losses GO:0022838 substrate-specific channel activity Losses GO:0022803 passive transmembrane transporter activity Losses GO:0015267 channel activity Losses GO:0016298 lipase activity Losses GO:0005509 calcium ion binding Losses GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Losses GO:0042834 peptidoglycan binding Losses GO:0008527 taste receptor activity Losses GO:0061134 peptidase regulator activity Losses GO:0004866 endopeptidase inhibitor activity Losses GO:0022834 ligand-gated channel activity Losses GO:0015276 ligand-gated ion channel activity Losses GO:0022836 gated channel activity Losses GO:0061135 endopeptidase regulator activity Losses GO:0070567 cytidylyltransferase activity Losses GO:0015081 sodium ion transmembrane transporter activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0004619 phosphoglycerate mutase activity Losses GO:0016500 protein-hormone receptor activity Losses GO:0004869 cysteine-type endopeptidase inhibitor activity Losses GO:0005230 extracellular ligand-gated ion channel activity Losses GO:0005272 sodium channel activity Losses GO:0046873 metal ion transmembrane transporter activity Losses GO:0008028 monocarboxylic acid transmembrane transporter activity Losses GO:0008066 glutamate receptor activity Losses GO:0016788 hydrolase activity, acting on ester bonds Losses GO:0004620 phospholipase activity Losses GO:0001875 lipopolysaccharide receptor activity Losses GO:0019531 oxalate transmembrane transporter activity Losses GO:0008046 axon guidance receptor activity Losses GO:0044748 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing Losses GO:0044736 acid-sensing ion channel activity Losses GO:0016211 ammonia ligase activity Losses GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity Losses GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity Losses GO:0047035 testosterone dehydrogenase (NAD+) activity Losses GO:0005007 fibroblast growth factor-activated receptor activity Losses GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific Losses GO:0032500 muramyl dipeptide binding Losses GO:0004396 hexokinase activity Losses GO:0004356 glutamate-ammonia ligase activity Losses GO:0004340 glucokinase activity Losses GO:0004339 glucan 1,4-alpha-glucosidase activity Losses GO:0004306 ethanolamine-phosphate cytidylyltransferase activity Losses GO:0004499 N,N-dimethylaniline monooxygenase activity Losses GO:0005324 long-chain fatty acid transporter activity Losses GO:0034185 apolipoprotein binding Losses GO:0032028 myosin head/neck binding Losses GO:0097108 hedgehog family protein binding Losses GO:0097109 neuroligin family protein binding Losses GO:0031489 myosin V binding Losses GO:0008865 fructokinase activity Losses GO:0016019 peptidoglycan receptor activity Losses GO:0019158 mannokinase activity Losses GO:0015499 formate transmembrane transporter activity Losses GO:0070854 myosin VI heavy chain binding Losses GO:0070855 myosin VI head/neck binding Losses GO:0030283 testosterone dehydrogenase [NAD(P)] activity Losses GO:0047747 cholate-CoA ligase activity Losses GO:0008579 JUN kinase phosphatase activity Losses GO:0015106 bicarbonate transmembrane transporter activity Losses GO:0015280 ligand-gated sodium channel activity Losses GO:0015245 fatty acid transporter activity Losses GO:0008134 transcription factor binding Losses GO:0030234 enzyme regulator activity Losses GO:0003993 acid phosphatase activity Losses GO:0005261 cation channel activity Losses GO:0015077 monovalent inorganic cation transmembrane transporter activity Losses GO:0061783 peptidoglycan muralytic activity Losses GO:0016868 intramolecular transferase activity, phosphotransferases Losses GO:0008081 phosphoric diester hydrolase activity Losses GO:0004867 serine-type endopeptidase inhibitor activity Losses GO:0005319 lipid transporter activity Losses GO:0008198 ferrous iron binding Novel expansions GO:0031208 POZ domain binding Novel expansions GO:0008199 ferric iron binding Novel expansions GO:0030414 peptidase inhibitor activity Novel expansions GO:0004806 triglyceride lipase activity Novel expansions GO:0004060 arylamine N-acetyltransferase activity Novel expansions GO:0009045 xylose isomerase activity Novel expansions GO:0004059 aralkylamine N-acetyltransferase activity Novel expansions GO:0004038 allantoinase activity Novel expansions GO:0032813 tumor necrosis factor receptor superfamily binding Novel expansions GO:0008496 mannan endo-1,6-alpha-mannosidase activity Novel expansions GO:0004392 heme oxygenase (decyclizing) activity Novel expansions GO:0016663 oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor Novel expansions GO:0005164 tumor necrosis factor receptor binding Novel expansions GO:0008810 cellulase activity Novel expansions GO:0004846 urate oxidase activity Novel expansions GO:0050897 cobalt ion binding Novel expansions GO:0015204 urea transmembrane transporter activity Novel expansions GO:0008146 sulfotransferase activity Novel expansions GO:0061134 peptidase regulator activity Novel expansions GO:0016860 intramolecular oxidoreductase activity Novel expansions GO:0015927 trehalase activity Novel expansions GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors Novel expansions GO:0005119 smoothened binding Novel expansions GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity Novel expansions GO:0000210 NAD+ diphosphatase activity Novel expansions GO:0050220 prostaglandin-E synthase activity Novel expansions GO:0008526 phosphatidylinositol transporter activity Novel expansions GO:0004555 alpha,alpha-trehalase activity Novel expansions GO:0018800 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity Novel expansions GO:0004857 enzyme inhibitor activity Novel expansions GO:0052689 carboxylic ester hydrolase activity Novel expansions GO:0017080 sodium channel regulator activity Novel expansions GO:0015081 sodium ion transmembrane transporter activity Extinctions GO:0046873 metal ion transmembrane transporter activity Extinctions GO:0005261 cation channel activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0005539 glycosaminoglycan binding Extinctions GO:0005272 sodium channel activity Extinctions GO:0004619 phosphoglycerate mutase activity Extinctions GO:0016500 protein-hormone receptor activity Extinctions GO:0004872 receptor activity Extinctions GO:0015077 monovalent inorganic cation transmembrane transporter activity Extinctions GO:0005216 ion channel activity Extinctions GO:0004930 G-protein coupled receptor activity Extinctions GO:0022838 substrate-specific channel activity Extinctions GO:0022803 passive transmembrane transporter activity Extinctions GO:0015267 channel activity Extinctions GO:0004857 enzyme inhibitor activity Extinctions GO:0060089 molecular transducer activity Extinctions GO:0004866 endopeptidase inhibitor activity Extinctions GO:0016868 intramolecular transferase activity, phosphotransferases Extinctions GO:0061135 endopeptidase regulator activity Extinctions GO:0001875 lipopolysaccharide receptor activity Extinctions GO:0044736 acid-sensing ion channel activity Extinctions GO:0032500 muramyl dipeptide binding Extinctions GO:0097108 hedgehog family protein binding Extinctions GO:0016019 peptidoglycan receptor activity Extinctions GO:0015280 ligand-gated sodium channel activity Extinctions GO:0022890 inorganic cation transmembrane transporter activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0038023 signaling receptor activity Extinctions GO:0008201 heparin binding Extinctions GO:0030414 peptidase inhibitor activity Extinctions GO:0015370 solute:sodium symporter activity Extinctions GO:0047631 ADP-ribose diphosphatase activity Extinctions GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Extinctions GO:0016286 small conductance calcium-activated potassium channel activity Extinctions GO:0004040 amidase activity Extinctions GO:0005094 Rho GDP-dissociation inhibitor activity Extinctions GO:0097322 7SK snRNA binding Extinctions GO:0008140 cAMP response element binding protein binding Extinctions GO:0050290 sphingomyelin phosphodiesterase D activity Extinctions GO:0004817 cysteine-tRNA ligase activity Extinctions GO:0008613 diuretic hormone activity Extinctions GO:0043890 N-acetylgalactosamine-6-sulfatase activity Extinctions GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity Extinctions GO:0061134 peptidase regulator activity Extinctions GO:0005543 phospholipid binding Extinctions GO:0008324 cation transmembrane transporter activity Extinctions GO:0030234 enzyme regulator activity Extinctions