GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0022836 gated channel activity Gains GO:0022857 transmembrane transporter activity Gains GO:0034061 DNA polymerase activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0005215 transporter activity Gains GO:0005267 potassium channel activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0015079 potassium ion transmembrane transporter activity Gains GO:0004447 iodide peroxidase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0005234 extracellularly glutamate-gated ion channel activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0022892 substrate-specific transporter activity Gains GO:0004714 transmembrane receptor protein tyrosine kinase activity Gains GO:0004035 alkaline phosphatase activity Gains GO:0015269 calcium-activated potassium channel activity Gains GO:0005227 calcium activated cation channel activity Gains GO:0005231 excitatory extracellular ligand-gated ion channel activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0019199 transmembrane receptor protein kinase activity Gains GO:0003887 DNA-directed DNA polymerase activity Gains GO:0070851 growth factor receptor binding Gains GO:0042834 peptidoglycan binding Gains GO:0005154 epidermal growth factor receptor binding Gains GO:0022839 ion gated channel activity Gains GO:0005261 cation channel activity Gains GO:0042393 histone binding Gains GO:0003700 DNA binding transcription factor activity Gains GO:0015293 symporter activity Gains GO:0005253 anion channel activity Gains GO:0008527 taste receptor activity Losses GO:0052689 carboxylic ester hydrolase activity Losses GO:0016787 hydrolase activity Losses GO:0061505 DNA topoisomerase II activity Losses GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Losses GO:0016775 phosphotransferase activity, nitrogenous group as acceptor Losses GO:0033041 sweet taste receptor activity Losses GO:0000182 rDNA binding Losses GO:0038023 signaling receptor activity Losses GO:0016298 lipase activity Losses GO:0003916 DNA topoisomerase activity Losses GO:0004871 signal transducer activity Losses GO:0035586 purinergic receptor activity Losses GO:0003696 satellite DNA binding Losses GO:0009881 photoreceptor activity Losses GO:0004872 receptor activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0000155 phosphorelay sensor kinase activity Losses GO:0004673 protein histidine kinase activity Losses GO:0060089 molecular transducer activity Losses GO:0003823 antigen binding Losses GO:0003677 DNA binding Losses GO:0099600 transmembrane receptor activity Losses GO:0004180 carboxypeptidase activity Losses GO:0004623 phospholipase A2 activity Losses GO:0004806 triglyceride lipase activity Losses GO:0016174 NAD(P)H oxidase activity Losses GO:0019955 cytokine binding Losses GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Losses GO:0008238 exopeptidase activity Losses GO:0035250 UDP-galactosyltransferase activity Losses GO:0016798 hydrolase activity, acting on glycosyl bonds Losses GO:0015179 L-amino acid transmembrane transporter activity Losses GO:0047915 ganglioside galactosyltransferase activity Losses GO:0004526 ribonuclease P activity Losses GO:0003676 nucleic acid binding Losses GO:0019239 deaminase activity Novel expansions GO:0052689 carboxylic ester hydrolase activity Extinctions GO:0004623 phospholipase A2 activity Extinctions GO:0008527 taste receptor activity Extinctions GO:0004526 ribonuclease P activity Extinctions GO:0008194 UDP-glycosyltransferase activity Extinctions GO:0008172 S-methyltransferase activity Extinctions GO:0015020 glucuronosyltransferase activity Extinctions GO:0004549 tRNA-specific ribonuclease activity Extinctions GO:0016298 lipase activity Extinctions GO:0019120 hydrolase activity, acting on acid halide bonds, in C-halide compounds Extinctions GO:0009378 four-way junction helicase activity Extinctions GO:0004061 arylformamidase activity Extinctions GO:0018786 haloalkane dehalogenase activity Extinctions GO:0050333 thiamin-triphosphatase activity Extinctions GO:0008196 vitellogenin receptor activity Extinctions GO:0030544 Hsp70 protein binding Extinctions GO:0008119 thiopurine S-methyltransferase activity Extinctions GO:0005460 UDP-glucose transmembrane transporter activity Extinctions GO:0005461 UDP-glucuronic acid transmembrane transporter activity Extinctions GO:0004371 glycerone kinase activity Extinctions GO:0003720 telomerase activity Extinctions GO:0003721 telomerase RNA reverse transcriptase activity Extinctions GO:0004419 hydroxymethylglutaryl-CoA lyase activity Extinctions GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Extinctions GO:0003833 beta-alanyl-dopamine synthase activity Extinctions GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity Extinctions GO:0016824 hydrolase activity, acting on acid halide bonds Extinctions GO:0003941 L-serine ammonia-lyase activity Extinctions GO:0004803 transposase activity Extinctions GO:0015078 hydrogen ion transmembrane transporter activity Extinctions GO:0016787 hydrolase activity Extinctions