GO:0022824 transmitter-gated ion channel activity Gains GO:0022835 transmitter-gated channel activity Gains GO:0004970 ionotropic glutamate receptor activity Gains GO:0005234 extracellularly glutamate-gated ion channel activity Gains GO:0005231 excitatory extracellular ligand-gated ion channel activity Gains GO:0008066 glutamate receptor activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0005230 extracellular ligand-gated ion channel activity Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0022834 ligand-gated channel activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Gains GO:0070330 aromatase activity Gains GO:0022857 transmembrane transporter activity Gains GO:0008756 o-succinylbenzoate-CoA ligase activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0034061 DNA polymerase activity Gains GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups Gains GO:0015075 ion transmembrane transporter activity Gains GO:0020037 heme binding Gains GO:0016725 oxidoreductase activity, acting on CH or CH2 groups Gains GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor Gains GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Gains GO:0061731 ribonucleoside-diphosphate reductase activity Gains GO:0046906 tetrapyrrole binding Gains GO:0042302 structural constituent of cuticle Gains GO:0005215 transporter activity Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0016783 sulfurtransferase activity Gains GO:0008010 structural constituent of chitin-based larval cuticle Gains GO:0005310 dicarboxylic acid transmembrane transporter activity Gains GO:0016405 CoA-ligase activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015267 channel activity Gains GO:0022836 gated channel activity Gains GO:0022892 substrate-specific transporter activity Gains GO:0016746 transferase activity, transferring acyl groups Gains GO:0016878 acid-thiol ligase activity Gains GO:1901505 carbohydrate derivative transmembrane transporter activity Gains GO:0017153 sodium:dicarboxylate symporter activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0008061 chitin binding Gains GO:0005214 structural constituent of chitin-based cuticle Gains GO:0016877 ligase activity, forming carbon-sulfur bonds Gains GO:0004104 cholinesterase activity Gains GO:0015645 fatty acid ligase activity Gains GO:0003990 acetylcholinesterase activity Gains GO:0004467 long-chain fatty acid-CoA ligase activity Gains GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Gains GO:0004497 monooxygenase activity Gains GO:0047915 ganglioside galactosyltransferase activity Gains GO:1901682 sulfur compound transmembrane transporter activity Gains GO:0016411 acylglycerol O-acyltransferase activity Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0005342 organic acid transmembrane transporter activity Gains GO:0046943 carboxylic acid transmembrane transporter activity Gains GO:0015144 carbohydrate transmembrane transporter activity Gains GO:0051119 sugar transmembrane transporter activity Gains GO:0015291 secondary active transmembrane transporter activity Gains GO:0030023 extracellular matrix constituent conferring elasticity Gains GO:0042947 glucoside transmembrane transporter activity Gains GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase Gains GO:0008836 diaminopimelate decarboxylase activity Gains GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase Gains GO:0043682 copper-transporting ATPase activity Gains GO:0004757 sepiapterin reductase activity Gains GO:0097493 structural molecule activity conferring elasticity Gains GO:0050897 cobalt ion binding Gains GO:0004557 alpha-galactosidase activity Gains GO:0004586 ornithine decarboxylase activity Gains GO:0003998 acylphosphatase activity Gains GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity Gains GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity Gains GO:0003943 N-acetylgalactosamine-4-sulfatase activity Gains GO:0004666 prostaglandin-endoperoxide synthase activity Gains GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity Gains GO:0004605 phosphatidate cytidylyltransferase activity Gains GO:0052692 raffinose alpha-galactosidase activity Gains GO:0015499 formate transmembrane transporter activity Gains GO:0004072 aspartate kinase activity Gains GO:0047200 tetrahydrodipicolinate N-acetyltransferase activity Gains GO:0004008 copper-exporting ATPase activity Gains GO:0015151 alpha-glucoside transmembrane transporter activity Gains GO:0015106 bicarbonate transmembrane transporter activity Gains GO:0008456 alpha-N-acetylgalactosaminidase activity Gains GO:0005368 taurine transmembrane transporter activity Gains GO:0005369 taurine:sodium symporter activity Gains GO:0019531 oxalate transmembrane transporter activity Gains GO:0004321 fatty-acyl-CoA synthase activity Gains GO:0046981 beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity Gains GO:0004493 methylmalonyl-CoA epimerase activity Gains GO:0008777 acetylornithine deacetylase activity Gains GO:0015574 trehalose transmembrane transporter activity Gains GO:0016209 antioxidant activity Gains GO:0005506 iron ion binding Gains GO:0008236 serine-type peptidase activity Gains GO:0017171 serine hydrolase activity Gains GO:0005343 organic acid:sodium symporter activity Gains GO:0008514 organic anion transmembrane transporter activity Gains GO:0015294 solute:cation symporter activity Gains GO:0004871 signal transducer activity Losses GO:0004872 receptor activity Losses GO:0038023 signaling receptor activity Losses GO:0060089 molecular transducer activity Losses GO:0046873 metal ion transmembrane transporter activity Losses GO:0022890 inorganic cation transmembrane transporter activity Losses GO:0008324 cation transmembrane transporter activity Losses GO:0004714 transmembrane receptor protein tyrosine kinase activity Losses GO:0099600 transmembrane receptor activity Losses GO:0015079 potassium ion transmembrane transporter activity Losses GO:0019199 transmembrane receptor protein kinase activity Losses GO:0005267 potassium channel activity Losses GO:0005500 juvenile hormone binding Losses GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0015077 monovalent inorganic cation transmembrane transporter activity Losses GO:0005102 receptor binding Losses GO:0015075 ion transmembrane transporter activity Losses GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Losses GO:0005515 protein binding Losses GO:0022836 gated channel activity Losses GO:0043169 cation binding Losses GO:0022843 voltage-gated cation channel activity Losses GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Losses GO:0047429 nucleoside-triphosphate diphosphatase activity Losses GO:0032453 histone demethylase activity (H3-K4 specific) Losses GO:0005249 voltage-gated potassium channel activity Losses GO:0005261 cation channel activity Losses GO:0022857 transmembrane transporter activity Losses GO:0099094 ligand-gated cation channel activity Losses GO:0042562 hormone binding Losses GO:0046872 metal ion binding Losses GO:0005509 calcium ion binding Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0004197 cysteine-type endopeptidase activity Losses GO:0022804 active transmembrane transporter activity Losses GO:0005244 voltage-gated ion channel activity Losses GO:0022832 voltage-gated channel activity Losses GO:0004497 monooxygenase activity Losses GO:0005506 iron ion binding Losses GO:0005544 calcium-dependent phospholipid binding Losses GO:0042169 SH2 domain binding Losses GO:0008013 beta-catenin binding Losses GO:0032451 demethylase activity Losses GO:0032452 histone demethylase activity Losses GO:0019840 isoprenoid binding Losses GO:0008199 ferric iron binding Losses GO:0015294 solute:cation symporter activity Losses GO:0015081 sodium ion transmembrane transporter activity Losses GO:0015108 chloride transmembrane transporter activity Losses GO:0046914 transition metal ion binding Losses GO:0016301 kinase activity Losses GO:0004672 protein kinase activity Losses GO:0022892 substrate-specific transporter activity Losses GO:0015103 inorganic anion transmembrane transporter activity Losses GO:0008395 steroid hydroxylase activity Losses GO:0005328 neurotransmitter:sodium symporter activity Losses GO:0015291 secondary active transmembrane transporter activity Losses GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Losses GO:0022853 active ion transmembrane transporter activity Losses GO:0004713 protein tyrosine kinase activity Losses GO:0016773 phosphotransferase activity, alcohol group as acceptor Losses GO:0005216 ion channel activity Losses GO:0022838 substrate-specific channel activity Losses GO:0070491 repressing transcription factor binding Losses GO:0005215 transporter activity Losses GO:0008134 transcription factor binding Losses GO:0005225 volume-sensitive anion channel activity Losses GO:0043559 insulin binding Losses GO:0008892 guanine deaminase activity Losses GO:0008865 fructokinase activity Losses GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Losses GO:0016743 carboxyl- or carbamoyltransferase activity Losses GO:0008579 JUN kinase phosphatase activity Losses GO:0008511 sodium:potassium:chloride symporter activity Losses GO:0050840 extracellular matrix binding Losses GO:0017151 DEAD/H-box RNA helicase binding Losses GO:0015088 copper uptake transmembrane transporter activity Losses GO:0050564 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity Losses GO:0005534 galactose binding Losses GO:0001784 phosphotyrosine residue binding Losses GO:0016531 copper chaperone activity Losses GO:0016532 superoxide dismutase copper chaperone activity Losses GO:0004598 peptidylamidoglycolate lyase activity Losses GO:0043047 single-stranded telomeric DNA binding Losses GO:0043992 histone acetyltransferase activity (H3-K9 specific) Losses GO:0050699 WW domain binding Losses GO:0003985 acetyl-CoA C-acetyltransferase activity Losses GO:0003986 acetyl-CoA hydrolase activity Losses GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Losses GO:0004503 monophenol monooxygenase activity Losses GO:0008068 extracellularly glutamate-gated chloride channel activity Losses GO:0047493 ceramide cholinephosphotransferase activity Losses GO:0030159 receptor signaling complex scaffold activity Losses GO:0001586 Gi/o-coupled serotonin receptor activity Losses GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity Losses GO:0046875 ephrin receptor binding Losses GO:0019158 mannokinase activity Losses GO:0008927 mannonate dehydratase activity Losses GO:0051010 microtubule plus-end binding Losses GO:0019135 deoxyhypusine monooxygenase activity Losses GO:0072320 volume-sensitive chloride channel activity Losses GO:0036263 L-DOPA monooxygenase activity Losses GO:0036264 dopamine monooxygenase activity Losses GO:0042767 ecdysteroid 22-hydroxylase activity Losses GO:0005009 insulin-activated receptor activity Losses GO:0004097 catechol oxidase activity Losses GO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity Losses GO:0004087 carbamoyl-phosphate synthase (ammonia) activity Losses GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Losses GO:0004070 aspartate carbamoyltransferase activity Losses GO:0004971 AMPA glutamate receptor activity Losses GO:0015277 kainate selective glutamate receptor activity Losses GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity Losses GO:0047880 erythrulose reductase activity Losses GO:0035013 myosuppressin receptor activity Losses GO:0045309 protein phosphorylated amino acid binding Losses GO:0051425 PTB domain binding Losses GO:0080023 3R-hydroxyacyl-CoA dehydratase activity Losses GO:0004396 hexokinase activity Losses GO:0098847 sequence-specific single stranded DNA binding Losses GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific Losses GO:0004340 glucokinase activity Losses GO:0004334 fumarylacetoacetase activity Losses GO:0004454 ketohexokinase activity Losses GO:0033192 calmodulin-dependent protein phosphatase activity Losses GO:0047623 adenosine-phosphate deaminase activity Losses GO:0033188 sphingomyelin synthase activity Losses GO:0003876 AMP deaminase activity Losses GO:0003844 1,4-alpha-glucan branching enzyme activity Losses GO:0004151 dihydroorotase activity Losses GO:0004170 dUTP diphosphatase activity Losses GO:0043560 insulin receptor substrate binding Losses GO:0022824 transmitter-gated ion channel activity Novel expansions GO:0022835 transmitter-gated channel activity Novel expansions GO:0004970 ionotropic glutamate receptor activity Novel expansions GO:0005234 extracellularly glutamate-gated ion channel activity Novel expansions GO:0005231 excitatory extracellular ligand-gated ion channel activity Novel expansions GO:0008066 glutamate receptor activity Novel expansions GO:0030594 neurotransmitter receptor activity Novel expansions GO:0005230 extracellular ligand-gated ion channel activity Novel expansions GO:0022834 ligand-gated channel activity Novel expansions GO:0015276 ligand-gated ion channel activity Novel expansions GO:0008756 o-succinylbenzoate-CoA ligase activity Novel expansions GO:0016877 ligase activity, forming carbon-sulfur bonds Novel expansions GO:0022836 gated channel activity Novel expansions GO:0016405 CoA-ligase activity Novel expansions GO:0016878 acid-thiol ligase activity Novel expansions GO:0005216 ion channel activity Novel expansions GO:0022838 substrate-specific channel activity Novel expansions GO:0022803 passive transmembrane transporter activity Novel expansions GO:0015267 channel activity Novel expansions GO:0022857 transmembrane transporter activity Novel expansions GO:0005215 transporter activity Novel expansions GO:0015075 ion transmembrane transporter activity Novel expansions GO:0004703 G-protein coupled receptor kinase activity Novel expansions GO:0017153 sodium:dicarboxylate symporter activity Novel expansions GO:0015645 fatty acid ligase activity Novel expansions GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor Novel expansions GO:0004784 superoxide dismutase activity Novel expansions GO:0004467 long-chain fatty acid-CoA ligase activity Novel expansions GO:0004888 transmembrane signaling receptor activity Novel expansions GO:0047915 ganglioside galactosyltransferase activity Novel expansions GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Novel expansions GO:0016162 cellulose 1,4-beta-cellobiosidase activity Novel expansions GO:0016174 NAD(P)H oxidase activity Novel expansions GO:0022891 substrate-specific transmembrane transporter activity Novel expansions GO:0099600 transmembrane receptor activity Novel expansions GO:0004525 ribonuclease III activity Novel expansions GO:0032296 double-stranded RNA-specific ribonuclease activity Novel expansions GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors Extinctions GO:0008892 guanine deaminase activity Extinctions GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Extinctions GO:0016531 copper chaperone activity Extinctions GO:0016532 superoxide dismutase copper chaperone activity Extinctions GO:0043047 single-stranded telomeric DNA binding Extinctions GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Extinctions GO:0004503 monophenol monooxygenase activity Extinctions GO:0008927 mannonate dehydratase activity Extinctions GO:0019135 deoxyhypusine monooxygenase activity Extinctions GO:0036263 L-DOPA monooxygenase activity Extinctions GO:0036264 dopamine monooxygenase activity Extinctions GO:0004097 catechol oxidase activity Extinctions GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity Extinctions GO:0098847 sequence-specific single stranded DNA binding Extinctions GO:0004454 ketohexokinase activity Extinctions GO:0046961 proton-transporting ATPase activity, rotational mechanism Extinctions GO:0005549 odorant binding Extinctions GO:0008020 G-protein coupled photoreceptor activity Extinctions GO:0015417 polyamine-transporting ATPase activity Extinctions GO:0015203 polyamine transmembrane transporter activity Extinctions GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism Extinctions GO:0004771 sterol esterase activity Extinctions GO:0016530 metallochaperone activity Extinctions GO:0042162 telomeric DNA binding Extinctions GO:0047429 nucleoside-triphosphate diphosphatase activity Extinctions GO:0042625 ATPase coupled ion transmembrane transporter activity Extinctions GO:0043169 cation binding Extinctions GO:0036442 hydrogen-exporting ATPase activity Extinctions GO:0004872 receptor activity Extinctions