GO:0004984	olfactory receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0004500	dopamine beta-monooxygenase activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0010181	FMN binding	Gains
GO:0005216	ion channel activity	Gains
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
GO:0005245	voltage-gated calcium channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0008146	sulfotransferase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0008237	metallopeptidase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Gains
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Gains
GO:0008332	low voltage-gated calcium channel activity	Gains
GO:0004014	adenosylmethionine decarboxylase activity	Gains
GO:0008449	N-acetylglucosamine-6-sulfatase activity	Gains
GO:0008890	glycine C-acetyltransferase activity	Gains
GO:0051371	muscle alpha-actinin binding	Gains
GO:0098518	polynucleotide phosphatase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0003676	nucleic acid binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0022832	voltage-gated channel activity	Gains
GO:0005244	voltage-gated ion channel activity	Gains
GO:0016615	malate dehydrogenase activity	Gains
GO:0008239	dipeptidyl-peptidase activity	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0004222	metalloendopeptidase activity	Gains
GO:0004518	nuclease activity	Gains
GO:0005215	transporter activity	Gains
GO:0005262	calcium channel activity	Gains
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Gains
GO:0043394	proteoglycan binding	Gains
GO:0043395	heparan sulfate proteoglycan binding	Gains
GO:0042805	actinin binding	Gains
GO:0004948	calcitonin receptor activity	Gains
GO:0016453	C-acetyltransferase activity	Gains
GO:0097642	calcitonin family receptor activity	Gains
GO:0004470	malic enzyme activity	Gains
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	Gains
GO:0051393	alpha-actinin binding	Gains
GO:0004713	protein tyrosine kinase activity	Gains
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	Gains
GO:0070491	repressing transcription factor binding	Gains
GO:0008227	G-protein coupled amine receptor activity	Gains
GO:0008324	cation transmembrane transporter activity	Gains
GO:0046872	metal ion binding	Gains
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
GO:0022836	gated channel activity	Gains
GO:0005261	cation channel activity	Gains
GO:0043169	cation binding	Gains
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0008233	peptidase activity	Losses
GO:0008270	zinc ion binding	Losses
GO:0004175	endopeptidase activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0009055	electron transfer activity	Losses
GO:0003677	DNA binding	Losses
GO:0003676	nucleic acid binding	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0071855	neuropeptide receptor binding	Losses
GO:0050591	quinine 3-monooxygenase activity	Losses
GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
GO:0004803	transposase activity	Losses
GO:0004518	nuclease activity	Losses
GO:0005184	neuropeptide hormone activity	Losses
GO:0046872	metal ion binding	Losses
GO:0004806	triglyceride lipase activity	Losses
GO:0005179	hormone activity	Losses
GO:0043169	cation binding	Losses
GO:0070330	aromatase activity	Losses
GO:0004690	cyclic nucleotide-dependent protein kinase activity	Losses
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
GO:0030246	carbohydrate binding	Losses
GO:0030247	polysaccharide binding	Losses
GO:0001871	pattern binding	Losses
GO:0048018	receptor ligand activity	Losses
GO:0004734	pyrimidodiazepine synthase activity	Losses
GO:0030267	glyoxylate reductase (NADP) activity	Losses
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0097493	structural molecule activity conferring elasticity	Losses
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Losses
GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Losses
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0050111	mycocerosate synthase activity	Losses
GO:0071861	tachykinin receptor binding	Losses
GO:0018445	prothoracicotrophic hormone activity	Losses
GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
GO:0045174	glutathione dehydrogenase (ascorbate) activity	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
GO:0030023	extracellular matrix constituent conferring elasticity	Losses
GO:0005122	torso binding	Losses
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
GO:0042947	glucoside transmembrane transporter activity	Losses
GO:0015574	trehalose transmembrane transporter activity	Losses
GO:0047964	glyoxylate reductase activity	Losses
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0004796	thromboxane-A synthase activity	Losses
GO:0004000	adenosine deaminase activity	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0004497	monooxygenase activity	Losses
GO:0030545	receptor regulator activity	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0004711	ribosomal protein S6 kinase activity	Losses
GO:0015037	peptide disulfide oxidoreductase activity	Losses
GO:0015038	glutathione disulfide oxidoreductase activity	Losses
GO:0008011	structural constituent of pupal chitin-based cuticle	Losses
GO:0004503	monophenol monooxygenase activity	Losses
GO:0003939	L-iditol 2-dehydrogenase activity	Losses
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Losses
GO:0015154	disaccharide transmembrane transporter activity	Losses
GO:0015157	oligosaccharide transmembrane transporter activity	Losses
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Losses
GO:0004337	geranyltranstransferase activity	Losses
GO:0016420	malonyltransferase activity	Losses
GO:0008200	ion channel inhibitor activity	Losses
GO:0016419	S-malonyltransferase activity	Losses
GO:0045735	nutrient reservoir activity	Losses
GO:0005212	structural constituent of eye lens	Losses
GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Losses
GO:0018685	alkane 1-monooxygenase activity	Losses
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	Losses
GO:0016248	channel inhibitor activity	Losses
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0004175	endopeptidase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0071855	neuropeptide receptor binding	Extinctions
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0009055	electron transfer activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0070011	peptidase activity, acting on L-amino acid peptides	Extinctions
GO:0008233	peptidase activity	Extinctions
GO:0048018	receptor ligand activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
GO:0071861	tachykinin receptor binding	Extinctions
GO:0018445	prothoracicotrophic hormone activity	Extinctions
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Extinctions
GO:0005122	torso binding	Extinctions
GO:0001664	G-protein coupled receptor binding	Extinctions
GO:0008200	ion channel inhibitor activity	Extinctions
GO:0016248	channel inhibitor activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0043169	cation binding	Extinctions
GO:0050591	quinine 3-monooxygenase activity	Extinctions
GO:0033777	lithocholate 6beta-hydroxylase activity	Extinctions
GO:0004222	metalloendopeptidase activity	Extinctions