EOG8GB9NT GO:0003677 3/22 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DV82W GO:0080019 172/601 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8DV82W GO:0004043 6/601 L-aminoadipate-semialdehyde dehydrogenase activity molecular_function "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] EOG8DV82W GO:0010025 2/601 wax biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] EOG8DV82W GO:0006629 2/601 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8DV82W GO:0016021 2/601 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DV82W GO:0050062 2/601 long-chain-fatty-acyl-CoA reductase activity molecular_function "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] EOG8DV82W GO:0005777 2/601 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8DV82W GO:0000166 1/601 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8DV82W GO:0003676 1/601 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DV82W GO:0005778 1/601 peroxisomal membrane cellular_component "The lipid bilayer surrounding a peroxisome." [GOC:mah] EOG8DV82W GO:0008340 1/601 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8DV82W GO:0006909 1/601 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8DV82W GO:0016746 1/601 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8XPSZV GO:0003677 197/409 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XPSZV GO:0000786 197/409 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8XPSZV GO:0006334 197/409 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8XPSZV GO:0005634 196/409 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XPSZV GO:0032008 25/409 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8XPSZV GO:0071230 25/409 cellular response to amino acid stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah] EOG8XPSZV GO:0032439 22/409 endosome localization biological_process "Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd] EOG8XPSZV GO:0007040 22/409 lysosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] EOG8XPSZV GO:0001919 22/409 regulation of receptor recycling biological_process "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] EOG8XPSZV GO:0071986 22/409 Ragulator complex cellular_component "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980] EOG8XPSZV GO:0042632 22/409 cholesterol homeostasis biological_process "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] EOG8XPSZV GO:0043410 22/409 positive regulation of MAPK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] EOG8XPSZV GO:0031902 3/409 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8XPSZV GO:0003964 1/409 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8XPSZV GO:0003723 1/409 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8WDGVH GO:0035556 5/22 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8WDGVH GO:0004629 1/22 phospholipase C activity molecular_function "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah] EOG8WDGVH GO:0007268 1/22 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8WDGVH GO:0004871 1/22 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8DV82B GO:0005509 18/61 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DV82B GO:0050829 1/61 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8D294S GO:0005769 1/50 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8D294S GO:0045886 1/50 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8D294S GO:0005886 1/50 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8D294S GO:0042734 1/50 presynaptic membrane cellular_component "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194] EOG8D294S GO:0007399 1/50 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8D294S GO:0030054 1/50 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8D294S GO:0043195 1/50 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8D294S GO:0008219 1/50 cell death biological_process "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis] EOG8D294S GO:0005811 1/50 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8D294S GO:0007274 1/50 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8D294S GO:0030514 1/50 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8WHC36 GO:0004601 1/27 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8V45Q0 GO:0048208 7/39 COPII vesicle coating biological_process "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233] EOG8V45Q0 GO:0000139 7/39 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8V45Q0 GO:0046872 1/39 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8V45Q1 GO:0031409 22/139 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8V45Q1 GO:0005576 19/139 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V45Q1 GO:0036094 7/139 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG8V45Q1 GO:0005215 5/139 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8V45Q1 GO:0008289 2/139 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8SXQSK GO:0003723 28/91 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8SXQSK GO:0035068 1/91 micro-ribonucleoprotein complex cellular_component "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182] EOG8SXQSK GO:0007279 1/91 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8SXQSK GO:0051964 1/91 negative regulation of synapse assembly biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] EOG8SXQSK GO:0043621 1/91 protein self-association molecular_function "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] EOG8SXQSK GO:0007288 1/91 sperm axoneme assembly biological_process "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684] EOG8SXQSK GO:0040011 1/91 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8SXQSK GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SXQSK GO:0050774 1/91 negative regulation of dendrite morphogenesis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8SXQSK GO:0016319 1/91 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8SXQSK GO:0008345 1/91 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8SXQSK GO:0042802 1/91 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8SXQSK GO:0050976 1/91 detection of mechanical stimulus involved in sensory perception of touch biological_process "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG8SXQSK GO:0009794 1/91 regulation of mitotic cell cycle, embryonic biological_process "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] EOG8SXQSK GO:0007409 1/91 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8SXQSK GO:0016758 1/91 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8SXQSK GO:0051028 1/91 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8SXQSK GO:0045448 1/91 mitotic cell cycle, embryonic biological_process "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] EOG8SXQSK GO:0007413 1/91 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8SXQSK GO:0048812 1/91 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8SXQSK GO:0007416 1/91 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8SXQSK GO:0050808 1/91 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG8SXQSK GO:0007614 1/91 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8SXQSK GO:0006417 1/91 regulation of translation biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8SXQSK GO:0031047 1/91 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8SXQSK GO:0048134 1/91 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG8SXQSK GO:0016442 1/91 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG8SXQSK GO:0007420 1/91 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8SXQSK GO:0008049 1/91 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8SXQSK GO:0048813 1/91 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8SXQSK GO:0050802 1/91 circadian sleep/wake cycle, sleep biological_process "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] EOG8SXQSK GO:0042127 1/91 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8SXQSK GO:0007528 1/91 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8SXQSK GO:0045475 1/91 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8SXQSK GO:0007616 1/91 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8SXQSK GO:0007349 1/91 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8SXQSK GO:0008355 1/91 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8SXQSK GO:0045886 1/91 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8SXQSK GO:0007623 1/91 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8SXQSK GO:0051823 1/91 regulation of synapse structural plasticity biological_process "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123] EOG8SXQSK GO:0017148 1/91 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8SXQSK GO:0007310 1/91 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8SXQSK GO:0007601 1/91 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8SXQSK GO:0031507 1/91 heterochromatin assembly biological_process "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] EOG8SXQSK GO:0007411 1/91 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SXQSK GO:0045571 1/91 negative regulation of imaginal disc growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] EOG8SXQSK GO:0007281 1/91 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8SXQSK GO:0005811 1/91 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8SXQSK GO:0007294 1/91 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8SXQSK GO:0048814 1/91 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8SXQSK GO:0050807 1/91 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG8SXQSK GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG898XHJ GO:0008076 3/13 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG898XHJ GO:0005249 3/13 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8VT8DX GO:0006811 1/19 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8VT8DX GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WQ3HX GO:0006915 31/91 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8WQ3HX GO:0004197 31/91 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WQ3HX GO:0005622 8/91 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8WQ3HX GO:0042981 8/91 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8WQ3HX GO:0008285 1/91 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8WQ3HX GO:0031638 1/91 zymogen activation biological_process "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] EOG8WQ3HX GO:0010506 1/91 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8WQ3HX GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WQ3HX GO:0012501 1/91 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8WQ3HX GO:0042803 1/91 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8WQ3HX GO:0016540 1/91 protein autoprocessing biological_process "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] EOG8WQ3HX GO:0035234 1/91 ectopic germ cell programmed cell death biological_process "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] EOG8WQ3HX GO:0046668 1/91 regulation of retinal cell programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] EOG8WQ3HX GO:0007552 1/91 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8WQ3HX GO:0048813 1/91 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8WQ3HX GO:0008258 1/91 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8WQ3HX GO:0004175 1/91 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WQ3HX GO:0046672 1/91 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WQ3HX GO:0007291 1/91 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8WQ3HX GO:0006919 1/91 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8WQ3HX GO:0010623 1/91 developmental programmed cell death biological_process "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] EOG8WQ3HX GO:0007516 1/91 hemocyte development biological_process "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8WQ3HX GO:0007417 1/91 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8WQ3HX GO:0007423 1/91 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8WQ3HX GO:0016322 1/91 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8WQ3HX GO:0045476 1/91 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8WQ3HX GO:0048749 1/91 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8WQ3HX GO:0035071 1/91 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8WQ3HX GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WQ3HX GO:0035070 1/91 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8WQ3HX GO:0001700 1/91 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8WQ3HX GO:0010941 1/91 regulation of cell death biological_process "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] EOG8WQ3HX GO:0008340 1/91 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8WQ3HX GO:0048102 1/91 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8NP9JJ GO:0004674 25/82 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8NP9JJ GO:0005524 25/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NP9JJ GO:0004713 24/82 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8NP9JJ GO:0009103 9/82 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG8NP9JJ GO:0016020 9/82 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NP9JJ GO:0040018 1/82 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8NP9JJ GO:0005737 1/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NP9JJ GO:0030307 1/82 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8NP9JJ GO:0032008 1/82 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG854CF4 GO:0046872 3/28 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG854CF4 GO:0003676 3/28 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616K5 GO:0046873 27/88 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8616K5 GO:0016020 26/88 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8616K5 GO:0016021 1/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616K5 GO:0006829 1/88 zinc II ion transport biological_process "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K5 GO:0005622 1/88 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8616K5 GO:0000139 1/88 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8616K5 GO:0016323 1/88 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8WQ3H4 GO:0032266 1/89 phosphatidylinositol-3-phosphate binding molecular_function "Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] EOG8WQ3H4 GO:0005737 1/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WQ3H4 GO:0000045 1/89 autophagosome assembly biological_process "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] EOG8WQ3H4 GO:0080025 1/89 phosphatidylinositol-3,5-bisphosphate binding molecular_function "Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324] EOG88WFGZ GO:0004252 1/18 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG88WFGZ GO:0046872 1/18 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88WFGZ GO:0003676 1/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M1F GO:0005795 98/220 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8T1M1F GO:0008378 92/220 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8T1M1F GO:0050512 6/220 lactosylceramide 4-alpha-galactosyltransferase activity molecular_function "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] EOG8T1M1F GO:0009247 1/220 glycolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] EOG8T1M1F GO:0006688 1/220 glycosphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] EOG8T1M1F GO:0035248 1/220 alpha-1,4-N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] EOG8T1M1F GO:0016787 1/220 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8T1M1F GO:0008376 1/220 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG8T1M1F GO:0045747 1/220 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8T1M1F GO:0043066 1/220 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8XSP59 GO:0016787 21/80 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XSP59 GO:0004622 1/80 lysophospholipase activity molecular_function "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] EOG8DV827 GO:0009987 1/101 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8WDGV7 GO:0042302 184/825 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8WDGV7 GO:0040003 5/825 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8WDGV7 GO:0031012 5/825 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8WDGV7 GO:0008010 5/825 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8WDGV7 GO:0022008 1/825 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8XKXMS GO:0006979 6/26 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8XKXMS GO:0020037 6/26 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8XKXMS GO:0004601 6/26 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8XKXMS GO:0003676 1/26 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XKXMS GO:0008270 1/26 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XKXMS GO:0004190 1/26 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8RR909 GO:0003677 1/25 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FJBQF GO:0007156 7/40 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8FJBQF GO:0016021 7/40 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FJBQF GO:0005509 7/40 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8FJBQF GO:0005886 5/40 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FJBQM GO:0016021 2/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FJBQM GO:0005230 2/92 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8FJBQM GO:0005886 2/92 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FJBQM GO:0022414 1/92 reproductive process biological_process "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] EOG8FJBQM GO:0030054 1/92 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8FJBQM GO:0007283 1/92 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8FJBQM GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FJBQM GO:0006402 1/92 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG8FJBQM GO:0030014 1/92 CCR4-NOT complex cellular_component "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136] EOG8FJBQM GO:0045202 1/92 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8FJBQM GO:0017148 1/92 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8BZQJK GO:0003824 27/97 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8BZQJK GO:0016301 2/97 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8BZQJK GO:0047710 1/97 bis(5'-adenosyl)-triphosphatase activity molecular_function "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [EC:3.6.1.29, RHEA:13896] EOG8BZQJK GO:0008252 1/97 nucleotidase activity molecular_function "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] EOG818F3G GO:0003723 2/14 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG818F3G GO:0003964 2/14 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG818F3G GO:0004519 1/14 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8WSZSF GO:0016272 26/74 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8WSZSF GO:0006457 26/74 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8WSZSF GO:0006909 1/74 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8WSZSF GO:0048477 1/74 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8T1M38 GO:0016021 25/54 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C5FZD GO:0016491 67/285 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8C5FZD GO:0004503 7/285 monophenol monooxygenase activity molecular_function "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136] EOG8C5FZD GO:0005576 5/285 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8C5FZD GO:0046872 4/285 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C5FZD GO:0042438 3/285 melanin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] EOG8C5FZD GO:0036264 3/285 dopamine monooxygenase activity molecular_function "Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533] EOG8C5FZD GO:0042417 3/285 dopamine metabolic process biological_process "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] EOG8C5FZD GO:0036263 3/285 L-DOPA monooxygenase activity molecular_function "Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533] EOG8C5FZD GO:0004097 2/285 catechol oxidase activity molecular_function "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] EOG8C5FZD GO:0006952 1/285 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8C5FZD GO:0005615 1/285 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8C5FZD GO:0006583 1/285 melanin biosynthetic process from tyrosine biological_process "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] EOG8WSZSJ GO:0006260 20/83 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8WSZSJ GO:0005634 19/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WSZSJ GO:0032508 1/83 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8WSZSJ GO:0000811 1/83 GINS complex cellular_component "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] EOG8WSZSJ GO:0000278 1/83 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8WSZSJ GO:0022008 1/83 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WSZSJ GO:1900087 1/83 positive regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8WSZSJ GO:0046331 1/83 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG87DCWX GO:0016787 125/753 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG87DCWX GO:0003990 29/753 acetylcholinesterase activity molecular_function "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] EOG87DCWX GO:0052689 10/753 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG87DCWX GO:0004104 5/753 cholinesterase activity molecular_function "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] EOG87DCWX GO:0005576 3/753 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87DCWX GO:0005524 1/753 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87DCWX GO:0006730 1/753 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG87DCWX GO:0004013 1/753 adenosylhomocysteinase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] EOG87DCWX GO:0003677 1/753 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87DCWX GO:0016021 1/753 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCWX GO:0006260 1/753 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8P8HZ4 GO:0003995 28/83 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8P8HZ4 GO:0050660 26/83 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8P8HZ4 GO:0036128 1/83 CatSper complex cellular_component "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039] EOG8P8HZ4 GO:0005875 1/83 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8P8HZ4 GO:0005811 1/83 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8S7N4Q GO:0008484 81/332 sulfuric ester hydrolase activity molecular_function "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] EOG8S7N4Q GO:0003943 34/332 N-acetylgalactosamine-4-sulfatase activity molecular_function "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] EOG8S7N4Q GO:0008270 1/332 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N4Q GO:0042742 1/332 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8GB9NN GO:0008270 31/132 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GB9NN GO:0006352 31/132 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG8GB9NN GO:0045893 23/132 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9NN GO:0005634 23/132 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9NN GO:0006355 8/132 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9NN GO:0003743 2/132 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8GB9NN GO:0005667 1/132 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8GB9NN GO:0048812 1/132 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8GB9NN GO:0008134 1/132 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8GB9NN GO:0006359 1/132 regulation of transcription from RNA polymerase III promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators] EOG8GB9NN GO:0006383 1/132 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG87DCWN GO:0016772 137/261 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8S7N42 GO:0005524 53/187 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8S7N42 GO:0004674 50/187 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8S7N42 GO:0035556 8/187 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8S7N42 GO:0000287 8/187 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8S7N42 GO:0016021 3/187 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N42 GO:0005840 3/187 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8S7N42 GO:0006468 2/187 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8S7N42 GO:0005515 2/187 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8S7N42 GO:0004683 2/187 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8S7N42 GO:0004672 2/187 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8S7N42 GO:0004711 1/187 ribosomal protein S6 kinase activity molecular_function "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] EOG8S7N42 GO:0046533 1/187 negative regulation of photoreceptor cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] EOG8S7N42 GO:0008340 1/187 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8S7N42 GO:0046777 1/187 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG8S7N42 GO:0008306 1/187 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG8S7N42 GO:0042308 1/187 negative regulation of protein import into nucleus biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] EOG8S7N42 GO:0005700 1/187 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8S7N42 GO:0035106 1/187 operant conditioning biological_process "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] EOG8S7N42 GO:0018105 1/187 peptidyl-serine phosphorylation biological_process "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] EOG8S7N42 GO:0050941 1/187 negative regulation of pigment cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] EOG8S7N42 GO:0016456 1/187 X chromosome located dosage compensation complex, transcription activating cellular_component "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu] EOG8S7N42 GO:0035175 1/187 histone kinase activity (H3-S10 specific) molecular_function "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] EOG8S7N42 GO:0046580 1/187 negative regulation of Ras protein signal transduction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8S7N42 GO:0031936 1/187 negative regulation of chromatin silencing biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] EOG8S7N42 GO:0005703 1/187 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG8S7N42 GO:0005705 1/187 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8S7N42 GO:0007275 1/187 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8S7N42 GO:0042683 1/187 negative regulation of compound eye cone cell fate specification biological_process "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] EOG8S7N42 GO:0007528 1/187 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8S7N42 GO:0004697 1/187 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8S7N42 GO:0045475 1/187 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8S7N42 GO:0007474 1/187 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8S7N42 GO:0043987 1/187 histone H3-S10 phosphorylation biological_process "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl] EOG8S7N42 GO:0031594 1/187 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8S7N42 GO:0051276 1/187 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8S7N42 GO:0048477 1/187 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8S7N42 GO:0016321 1/187 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8S7N42 GO:0003677 1/187 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8S7N42 GO:0006351 1/187 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8S7N42 GO:0016572 1/187 histone phosphorylation biological_process "The modification of histones by addition of phosphate groups." [GOC:ai] EOG8S7N42 GO:0006325 1/187 chromatin organization biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] EOG8S7N42 GO:0000228 1/187 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8WSZS1 GO:0016765 28/111 transferase activity, transferring alkyl or aryl (other than methyl) groups molecular_function "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8WSZS1 GO:0008834 5/111 di-trans,poly-cis-decaprenylcistransferase activity molecular_function "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] EOG8WSZS1 GO:0052689 1/111 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8WSZS1 GO:0006909 1/111 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8FJBQ4 GO:0016255 14/37 attachment of GPI anchor to protein biological_process "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] EOG8FJBQ4 GO:0042765 14/37 GPI-anchor transamidase complex cellular_component "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] EOG8FJBQ4 GO:0005506 3/37 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8FJBQ4 GO:0031418 3/37 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8FJBQ4 GO:0016706 3/37 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG8FJBQ4 GO:0016491 1/37 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8FJBQ4 GO:0042996 1/37 regulation of Golgi to plasma membrane protein transport biological_process "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] EOG8FJBQ4 GO:0045313 1/37 rhabdomere membrane biogenesis biological_process "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] EOG8WQ3HK GO:0055114 1/79 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8DZ49F GO:0015018 29/89 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] EOG8DZ49F GO:0016020 28/89 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DZ49F GO:0015020 1/89 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG8DZ49F GO:0046872 1/89 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DZ49F GO:0006486 1/89 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8DZ49F GO:0030206 1/89 chondroitin sulfate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] EOG8DZ49F GO:0000139 1/89 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8DZ49F GO:0015012 1/89 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG8DZ49F GO:0030166 1/89 proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] EOG8DZ49F GO:0016021 1/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HP9 GO:0004035 127/508 alkaline phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] EOG879HP9 GO:0016791 75/508 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG879HP9 GO:0035094 1/508 response to nicotine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] EOG879HP9 GO:0003824 1/508 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG879HP9 GO:0016021 1/508 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HP9 GO:0005576 1/508 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG879HP9 GO:0005615 1/508 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG879HP9 GO:0031225 1/508 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG879HP9 GO:0046872 1/508 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG879HP9 GO:0007399 1/508 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG879HP9 GO:0032504 1/508 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG879HP9 GO:0042045 1/508 epithelial fluid transport biological_process "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] EOG879HP9 GO:0005886 1/508 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81G5KP GO:0016881 56/176 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG81G5KP GO:0004842 5/176 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81G5KP GO:0045089 1/176 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG81G5KP GO:0050829 1/176 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG81G5KP GO:0007140 1/176 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG81G5KP GO:0008049 1/176 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG81G5KP GO:0007619 1/176 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG81G5KP GO:0007283 1/176 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG81G5KP GO:0016567 1/176 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG88PQ10 GO:0003677 8/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88PQ10 GO:0003676 2/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86DPJ5 GO:0004252 4/7 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG88PQ18 GO:0005846 5/37 nuclear cap binding complex cellular_component "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] EOG88PQ18 GO:0000339 5/37 RNA cap binding molecular_function "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] EOG88PQ18 GO:0045292 5/37 mRNA cis splicing, via spliceosome biological_process "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897] EOG88PQ18 GO:0051028 5/37 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89PDFX GO:0004721 1/64 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG89CSNJ GO:0004252 1/25 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8D55C1 GO:0005524 27/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D55C1 GO:0004674 27/90 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8D55C1 GO:0007391 1/90 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8D55C1 GO:0045201 1/90 maintenance of neuroblast polarity biological_process "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] EOG8D55C1 GO:0007052 1/90 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8D55C1 GO:0005737 1/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D55C1 GO:0016325 1/90 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8D55C1 GO:0004672 1/90 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8D55C1 GO:0007163 1/90 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8D55C1 GO:0005634 1/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55C1 GO:0046328 1/90 regulation of JNK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8D55C1 GO:0045451 1/90 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8D55C1 GO:0006468 1/90 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8D55C1 GO:0008340 1/90 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8D55C1 GO:0043065 1/90 positive regulation of apoptotic process biological_process "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8D55C1 GO:0055059 1/90 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8D55C1 GO:0030709 1/90 border follicle cell delamination biological_process "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] EOG866Z44 GO:0004871 24/133 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG866Z44 GO:0006351 20/133 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG866Z44 GO:0006355 20/133 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0005634 20/133 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG866Z44 GO:0003677 19/133 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG866Z44 GO:0003678 5/133 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG866Z44 GO:0006281 5/133 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG866Z44 GO:0000723 5/133 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG866Z44 GO:0005524 2/133 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG866Z44 GO:0045944 1/133 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0035147 1/133 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG866Z44 GO:0006357 1/133 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0043565 1/133 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG866Z44 GO:0007427 1/133 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG866Z44 GO:0046982 1/133 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG866Z44 GO:0043234 1/133 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG866Z44 GO:0003700 1/133 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SR0C1 GO:0005525 27/168 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8SR0C1 GO:0007264 27/168 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8SR0C1 GO:0015031 24/168 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8SR0C1 GO:0008168 4/168 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8SR0C1 GO:0030798 3/168 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG8SR0C1 GO:0016740 2/168 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8SR0C1 GO:0006184 1/168 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8SR0C1 GO:0006887 1/168 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8SR0C1 GO:0019010 1/168 farnesoic acid O-methyltransferase activity molecular_function "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] EOG8SR0C1 GO:0048786 1/168 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8SR0C1 GO:0045202 1/168 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8SR0C1 GO:0030054 1/168 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8SR0C1 GO:0006718 1/168 juvenile hormone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] EOG8SR0C1 GO:0035049 1/168 juvenile hormone acid methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] EOG8SR0C1 GO:0007186 1/168 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8SR0C1 GO:0008021 1/168 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8SR0C1 GO:0004871 1/168 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8SR0C1 GO:0007269 1/168 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8SR0C1 GO:0005834 1/168 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG8SR0C1 GO:0048790 1/168 maintenance of presynaptic active zone structure biological_process "The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] EOG8SR0C1 GO:0004767 1/168 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8SR0C1 GO:0016192 1/168 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8D55CJ GO:0008532 5/138 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] EOG8D55CJ GO:0016740 3/138 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8D55CJ GO:0005506 1/138 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8D55CJ GO:0007218 1/138 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8D55CJ GO:0002121 1/138 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8D55CJ GO:0008109 1/138 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] EOG8D55CJ GO:0020037 1/138 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8D55CJ GO:0016705 1/138 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8D55CM GO:0005576 40/210 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8D55CM GO:0005578 2/210 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8D55CM GO:0007411 2/210 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8D55CM GO:0008045 2/210 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8D55CM GO:2000289 2/210 regulation of photoreceptor cell axon guidance biological_process "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah] EOG8D55CM GO:0070983 2/210 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8D55CM GO:0008347 2/210 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8D55CM GO:0016021 1/210 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D55CM GO:0005515 1/210 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D55CM GO:0016200 1/210 synaptic target attraction biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] EOG8D55CM GO:0008039 1/210 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8D55CM GO:0055085 1/210 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8D55CM GO:0007432 1/210 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG84J4ZX GO:0046872 52/224 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84J4ZX GO:0016787 45/224 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG84J4ZX GO:0004177 13/224 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG84J4ZX GO:0005829 1/224 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84J4ZX GO:0006508 1/224 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG84J4ZX GO:0022008 1/224 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84J4ZX GO:0070006 1/224 metalloaminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8H74RZ GO:0003995 3/162 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8H74RZ GO:0050660 3/162 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8H74RZ GO:0003730 1/162 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8H74RZ GO:0005737 1/162 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84J4ZT GO:0006909 1/84 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84J4ZT GO:0005884 1/84 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG84J4ZT GO:0005737 1/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84J4ZT GO:0016021 1/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84J4ZT GO:0003779 1/84 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG84J4ZT GO:0005829 1/84 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84J4ZT GO:0030041 1/84 actin filament polymerization biological_process "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG84J4ZT GO:0005576 1/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG84J4ZT GO:0046872 1/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84J4ZT GO:0005215 1/84 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8H74RS GO:0007155 13/151 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8H74RS GO:0032225 1/151 regulation of synaptic transmission, dopaminergic biological_process "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] EOG8H74RS GO:0000775 1/151 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8H74RS GO:0008270 1/151 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H74RS GO:0007067 1/151 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8H74RS GO:0031463 1/151 Cul3-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] EOG8H74RS GO:0030674 1/151 protein binding, bridging molecular_function "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw] EOG8H74RS GO:0008344 1/151 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8H74RS GO:0045938 1/151 positive regulation of circadian sleep/wake cycle, sleep biological_process "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] EOG8H74RS GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8H74RS GO:0005634 1/151 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84J4ZN GO:0007099 1/86 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG84J4ZN GO:0005813 1/86 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG84J4ZN GO:0005814 1/86 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG84J4ZN GO:0051297 1/86 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG84J4ZN GO:0051298 1/86 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG84J4ZN GO:0010457 1/86 centriole-centriole cohesion biological_process "The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] EOG84J4ZN GO:0007052 1/86 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8VHNQ5 GO:0005840 5/86 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8VHNQ5 GO:0006310 1/86 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8VHNQ5 GO:0003735 1/86 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8VHNQ5 GO:0006302 1/86 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG8VHNQ5 GO:0003677 1/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H74RF GO:0005524 1/37 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H74RF GO:0004674 1/37 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8H74RF GO:0008270 1/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG805VGV GO:0016491 25/68 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG805VGT GO:0031047 1/262 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG805VGT GO:0048477 1/262 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG805VGT GO:0045892 1/262 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG805VGT GO:0005634 1/262 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8KSS23 GO:0005328 6/27 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8KSS23 GO:0016021 6/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KSS26 GO:0003700 1/24 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8KSS26 GO:0008270 1/24 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8KSS26 GO:0043565 1/24 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG805VGF GO:0008270 17/66 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZDZ GO:0003677 24/147 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FTZDZ GO:0005634 2/147 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FTZDZ GO:0045197 1/147 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8FTZDZ GO:0007427 1/147 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0007428 1/147 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8FTZDZ GO:0006355 1/147 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8FTZDZ GO:0035297 1/147 regulation of Malpighian tubule diameter biological_process "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] EOG8FTZDZ GO:0007442 1/147 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG8FTZDZ GO:0016477 1/147 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8FTZDZ GO:0008258 1/147 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8FTZDZ GO:0007426 1/147 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0003700 1/147 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FTZDZ GO:0007010 1/147 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8FTZDZ GO:0007424 1/147 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8FTZDZ GO:0007431 1/147 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8FTZDZ GO:0007443 1/147 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8FTZDZ GO:0035149 1/147 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0008360 1/147 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FTZDZ GO:0003676 1/147 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZDZ GO:0046872 1/147 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FTZDZ GO:0007417 1/147 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8FTZDZ GO:0007391 1/147 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FTZDZ GO:0061024 1/147 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8FTZDZ GO:0008104 1/147 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8FTZDZ GO:0007435 1/147 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8FTZDZ GO:0008406 1/147 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8577PS GO:0016021 7/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V19FS GO:0016787 15/283 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8V19FS GO:0050357 6/283 tropinesterase activity molecular_function "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307] EOG8V19FS GO:0007275 1/283 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8V19FS GO:0003676 1/283 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V19FS GO:0017171 1/283 serine hydrolase activity molecular_function "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase] EOG8V19FS GO:0000166 1/283 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8V19FS GO:0007586 1/283 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8V19FS GO:0008152 1/283 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8V19FS GO:0009636 1/283 response to toxic substance biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] EOG8V19FN GO:0008479 28/76 queuine tRNA-ribosyltransferase activity molecular_function "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] EOG8V19FN GO:0008616 28/76 queuosine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732] EOG8V19FN GO:0008270 18/76 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8V19F7 GO:0050660 31/102 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8V19F7 GO:0008762 30/102 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG8V19F7 GO:0004458 2/102 D-lactate dehydrogenase (cytochrome) activity molecular_function "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] EOG8V19F7 GO:0003824 1/102 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG85QKVN GO:0003700 23/93 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85QKVN GO:0043565 22/93 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85QKVN GO:0005991 1/93 trehalose metabolic process biological_process "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] EOG85QKVN GO:0035074 1/93 pupation biological_process "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] EOG85QKVN GO:0042594 1/93 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG85QKVN GO:0000980 1/93 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG85QKVN GO:0035073 1/93 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG85QKVN GO:0006355 1/93 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85QKVN GO:0007591 1/93 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG85QKVN GO:0001105 1/93 RNA polymerase II transcription coactivator activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG85QKVN GO:0006641 1/93 triglyceride metabolic process biological_process "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732] EOG85QKVN GO:0001102 1/93 RNA polymerase II activating transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] EOG85QKVN GO:0007552 1/93 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG85QKVN GO:0046982 1/93 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG85QKVN GO:0045944 1/93 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG805VG7 GO:0005506 679/2000 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG805VG7 GO:0020037 679/2000 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG805VG7 GO:0016705 629/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG805VG7 GO:0004497 607/2000 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG805VG7 GO:0070330 31/2000 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG805VG7 GO:0005789 25/2000 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG805VG7 GO:0050591 15/2000 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG805VG7 GO:0004796 4/2000 thromboxane-A synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140] EOG805VG7 GO:0031000 2/2000 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG805VG7 GO:0009055 2/2000 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG805VG7 GO:0016712 2/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG805VG7 GO:0017085 2/2000 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG805VG7 GO:0006697 1/2000 ecdysone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] EOG805VG7 GO:0050829 1/2000 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG805VG7 GO:0030178 1/2000 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG805VG7 GO:0017143 1/2000 insecticide metabolic process biological_process "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0046701 1/2000 insecticide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0022416 1/2000 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG805VG7 GO:0042742 1/2000 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG805VG7 GO:0048252 1/2000 lauric acid metabolic process biological_process "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid] EOG805VG7 GO:0016020 1/2000 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VG7 GO:1901563 1/2000 response to camptothecin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] EOG805VG7 GO:0018685 1/2000 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG805VG7 GO:0033777 1/2000 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG805VG7 GO:0002118 1/2000 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG805VG7 GO:0046683 1/2000 response to organophosphorus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] EOG805VG7 GO:0035220 1/2000 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG805VG7 GO:0048638 1/2000 regulation of developmental growth biological_process "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] EOG805VG7 GO:0040040 1/2000 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG805VG7 GO:0046680 1/2000 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG805VG7 GO:0046689 1/2000 response to mercury ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] EOG8W9MKG GO:0018024 23/105 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8W9MKG GO:0042799 2/105 histone methyltransferase activity (H4-K20 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] EOG8W9MKG GO:0016571 2/105 histone methylation biological_process "The modification of histones by addition of methyl groups." [GOC:ai] EOG8W9MKG GO:0006355 2/105 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8W9MKG GO:0007067 2/105 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8W9MKG GO:0005634 2/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8W9MKG GO:0006351 2/105 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8W9MKG GO:0005700 2/105 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8W9MKG GO:0030261 1/105 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8W9MKG GO:0034771 1/105 histone H4-K20 monomethylation biological_process "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] EOG8W9MKG GO:0034770 1/105 histone H4-K20 methylation biological_process "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] EOG8W9MKG GO:0000077 1/105 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG8W9MHS GO:0004970 6/83 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8W9MHS GO:0005234 6/83 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8W9MHS GO:0016020 4/83 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8W9MHS GO:0016021 2/83 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KWN97 GO:0046872 2/23 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KWN97 GO:0003676 2/23 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PP0Z9 GO:0005634 25/59 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PP0Z9 GO:0000079 23/59 regulation of cyclin-dependent protein serine/threonine kinase activity biological_process "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] EOG8PP0Z9 GO:0051301 22/59 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8PP0Z9 GO:0007049 22/59 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8PP0Z9 GO:0045495 1/59 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG8PP0Z9 GO:0000775 1/59 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8PP0Z9 GO:0008608 1/59 attachment of spindle microtubules to kinetochore biological_process "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] EOG8PP0Z9 GO:0009987 1/59 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8PP0Z9 GO:0006974 1/59 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8PP0Z9 GO:0005737 1/59 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PP0Z9 GO:0007079 1/59 mitotic chromosome movement towards spindle pole biological_process "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] EOG8PP0Z9 GO:0005819 1/59 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8PP0Z9 GO:0000086 1/59 G2/M transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] EOG8PP0Z9 GO:0051233 1/59 spindle midzone cellular_component "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] EOG8PP0Z9 GO:0001700 1/59 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8PP0Z9 GO:0035561 1/59 regulation of chromatin binding biological_process "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] EOG8PP0Z9 GO:0000281 1/59 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8PP0Z9 GO:0005515 1/59 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8PP0Z9 GO:0035186 1/59 syncytial blastoderm mitotic cell cycle biological_process "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] EOG8PP0Z9 GO:0016538 1/59 cyclin-dependent protein serine/threonine kinase regulator activity molecular_function "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] EOG8C8B6T GO:0003723 1/13 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DBWV6 GO:0005576 6/108 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8DBWV6 GO:0040007 2/108 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8DBWV6 GO:0005200 1/108 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8DBWV6 GO:0007010 1/108 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8DBWV6 GO:0005884 1/108 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG8DBWV6 GO:0005869 1/108 dynactin complex cellular_component "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] EOG8JWXVG GO:0005634 180/654 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JWXVG GO:0003700 176/654 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8JWXVG GO:0003677 166/654 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JWXVG GO:0006351 164/654 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8JWXVG GO:0045944 7/654 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8JWXVG GO:0007507 3/654 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8JWXVG GO:0006366 3/654 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8JWXVG GO:0061327 3/654 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8JWXVG GO:0035051 3/654 cardiocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] EOG8JWXVG GO:0035050 2/654 embryonic heart tube development biological_process "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] EOG8JWXVG GO:0030381 2/654 chorion-containing eggshell pattern formation biological_process "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] EOG8JWXVG GO:0035223 2/654 leg disc pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf] EOG8JWXVG GO:0000122 2/654 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8JWXVG GO:0003705 2/654 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8JWXVG GO:0003015 2/654 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG8JWXVG GO:0042684 2/654 cardioblast cell fate commitment biological_process "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8JWXVG GO:0042659 2/654 regulation of cell fate specification biological_process "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] EOG8JWXVG GO:0035294 1/654 determination of wing disc primordium biological_process "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238] EOG8JWXVG GO:0007525 1/654 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8JWXVG GO:0007417 1/654 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8JWXVG GO:0014018 1/654 neuroblast fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] EOG8JWXVG GO:0048066 1/654 developmental pigmentation biological_process "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] EOG8JWXVG GO:0022008 1/654 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8JWXVG GO:0007409 1/654 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8JWXVG GO:0007476 1/654 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8JWXVG GO:0001700 1/654 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8JWXVG GO:0007509 1/654 mesoderm migration involved in gastrulation biological_process "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] EOG8JWXVG GO:0001709 1/654 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8JWXVG GO:0000981 1/654 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8JWXVG GO:0014019 1/654 neuroblast development biological_process "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] EOG8JWXVG GO:0005515 1/654 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JWXVG GO:0010629 1/654 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8JWXVG GO:0007280 1/654 pole cell migration biological_process "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] EOG8JWXVG GO:0007402 1/654 ganglion mother cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG8JWXVG GO:0048100 1/654 wing disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] EOG8JWXVG GO:0051890 1/654 regulation of cardioblast differentiation biological_process "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] EOG8JWXVG GO:0048665 1/654 neuron fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] EOG8JWXVG GO:0035265 1/654 organ growth biological_process "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] EOG8JWXVG GO:0001158 1/654 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8JWXVG GO:0007411 1/654 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8JWXVG GO:0001745 1/654 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8JWXVG GO:0007443 1/654 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8JWXVG GO:0001227 1/654 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] EOG8JWXVG GO:0007442 1/654 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG8JWXVG GO:0010468 1/654 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8JWXVG GO:0051960 1/654 regulation of nervous system development biological_process "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] EOG8JWXVG GO:0000977 1/654 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG8JWXVG GO:0007494 1/654 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8JWXVG GO:0007472 1/654 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8JWXVG GO:0001226 1/654 RNA polymerase II transcription corepressor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] EOG8JWXVG GO:0042803 1/654 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8JWXVG GO:0006355 1/654 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8B5RKQ GO:0005622 1/19 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8B5RKQ GO:0007264 1/19 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8B5RKQ GO:0051056 1/19 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8B5RKQ GO:0005085 1/19 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8DBWV2 GO:0005524 24/78 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DBWV2 GO:0017111 23/78 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8DBWV2 GO:0008568 1/78 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8JWXVH GO:0003968 9/121 RNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] EOG8JWXVH GO:0008080 5/121 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8P8J15 GO:0007218 6/46 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8P8J15 GO:0005576 3/46 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8P8J15 GO:0040014 3/46 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8P8J15 GO:0032095 3/46 regulation of response to food biological_process "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] EOG8P8J15 GO:0005184 3/46 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8P8J15 GO:0045793 1/46 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8P8J15 GO:0007623 1/46 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8P8J15 GO:0007186 1/46 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8P8J15 GO:0035177 1/46 larval foraging behavior biological_process "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] EOG8P8J15 GO:0040018 1/46 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P8J15 GO:0090062 1/46 regulation of trehalose metabolic process biological_process "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb] EOG8P8J15 GO:0005615 1/46 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8P8J15 GO:0046628 1/46 positive regulation of insulin receptor signaling pathway biological_process "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8P8J15 GO:0048512 1/46 circadian behavior biological_process "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] EOG8P8J15 GO:0070374 1/46 positive regulation of ERK1 and ERK2 cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah] EOG8P8J15 GO:0043025 1/46 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8P8J15 GO:0005179 1/46 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG8P8J15 GO:0071859 1/46 neuropeptide F receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah] EOG8P8J15 GO:0008343 1/46 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG8P8J15 GO:0030424 1/46 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8P8J15 GO:0008049 1/46 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8P8J15 GO:0030536 1/46 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8P8J15 GO:0010906 1/46 regulation of glucose metabolic process biological_process "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] EOG8P8J15 GO:0071855 1/46 neuropeptide receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] EOG8P8J15 GO:0035264 1/46 multicellular organism growth biological_process "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] EOG8P8J15 GO:0008340 1/46 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8P8J15 GO:0045475 1/46 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8P8J15 GO:0008345 1/46 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG81K1SV GO:0004930 3/37 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG81K1SV GO:0016021 3/37 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81K1SV GO:0004984 3/37 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG81K1SV GO:0005549 3/37 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG81K1SV GO:0005886 2/37 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MPM40 GO:0005525 24/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8MPM40 GO:0003924 23/90 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8MPM40 GO:0003746 2/90 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8MPM40 GO:0005682 1/90 U5 snRNP cellular_component "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] EOG8MPM40 GO:0071011 1/90 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8MPM40 GO:0019013 1/90 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8MPM40 GO:0006414 1/90 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8MPM40 GO:0030529 1/90 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8MPM40 GO:0030532 1/90 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8MPM40 GO:0071013 1/90 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8MPM40 GO:0000398 1/90 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8MPM40 GO:0005829 1/90 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG81K1SR GO:0008270 44/198 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1SR GO:0043154 1/198 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0007423 1/198 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG81K1SR GO:0004842 1/198 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81K1SR GO:0003677 1/198 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81K1SR GO:0007289 1/198 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG81K1SR GO:0007283 1/198 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG81K1SR GO:0019788 1/198 NEDD8 transferase activity molecular_function "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] EOG81K1SR GO:0005737 1/198 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81K1SR GO:0007298 1/198 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG81K1SR GO:0051865 1/198 protein autoubiquitination biological_process "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] EOG81K1SR GO:0006352 1/198 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG81K1SR GO:0008407 1/198 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG81K1SR GO:0009987 1/198 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG81K1SR GO:0007275 1/198 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81K1SR GO:0008354 1/198 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG81K1SR GO:0045035 1/198 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG81K1SR GO:0048800 1/198 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG81K1SR GO:1990001 1/198 inhibition of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137] EOG81K1SR GO:0005634 1/198 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81K1SR GO:0005515 1/198 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81K1SR GO:0046673 1/198 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG81K1SR GO:0031398 1/198 positive regulation of protein ubiquitination biological_process "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] EOG81K1SR GO:0016055 1/198 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG81K1SR GO:0097340 1/198 inhibition of cysteine-type endopeptidase activity biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739] EOG81K1SR GO:0019899 1/198 enzyme binding molecular_function "Interacting selectively and non-covalently with any enzyme." [GOC:jl] EOG81K1SR GO:0090263 1/198 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG81K1SR GO:0043066 1/198 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0042787 1/198 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG81K1SR GO:0006915 1/198 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG81K1SR GO:0004869 1/198 cysteine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] EOG8MPM4H GO:0003676 2/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MPM4H GO:0046872 2/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MPM4H GO:0005634 1/19 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DBWVQ GO:0016021 21/71 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWVQ GO:0015171 1/71 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8DBWVQ GO:0003333 1/71 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8HMMQB GO:0046872 1/22 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HMMQB GO:0003824 1/22 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8JWXV8 GO:0000242 1/91 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8JWXV8 GO:0007283 1/91 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8JWXV8 GO:0035869 1/91 ciliary transition zone cellular_component "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition." [GOC:cilia, GOC:kmv, PMID:21422230] EOG8JWXV8 GO:0042073 1/91 intraciliary transport biological_process "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374] EOG8JWXV8 GO:0042384 1/91 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8JWXV8 GO:0008344 1/91 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8JWXV8 GO:0035082 1/91 axoneme assembly biological_process "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] EOG8JWXV8 GO:0048935 1/91 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG8NP9K1 GO:0008137 9/57 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8NP9K1 GO:0042773 6/57 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8NP9K1 GO:0006120 1/57 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG8NP9K1 GO:0031966 1/57 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG8NP9K1 GO:0016021 1/57 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NP9K1 GO:0070469 1/57 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8NP9K3 GO:0030154 1/86 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8NP9K3 GO:0007275 1/86 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8NP9K3 GO:0016020 1/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NP9K3 GO:0016021 1/86 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NP9K3 GO:0007283 1/86 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8J6V52 GO:0007017 1/82 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8J6V52 GO:0005874 1/82 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8J6V52 GO:0005525 1/82 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8J6V52 GO:0005200 1/82 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG87H83V GO:0005886 1/19 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87H83V GO:0005509 1/19 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG87H83V GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87H83V GO:0007156 1/19 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8J6V50 GO:0016491 6/48 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8J6V50 GO:0016020 1/48 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8J6V50 GO:0045475 1/48 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8J6V50 GO:0005528 1/48 FK506 binding molecular_function "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] EOG8J6V50 GO:0005515 1/48 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8J6V50 GO:0005829 1/48 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8J6V50 GO:0042176 1/48 regulation of protein catabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] EOG8J6V50 GO:0000413 1/48 protein peptidyl-prolyl isomerization biological_process "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] EOG8J6V50 GO:0003755 1/48 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8J6V50 GO:1901873 1/48 regulation of post-translational protein modification biological_process "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] EOG8J6V50 GO:0018208 1/48 peptidyl-proline modification biological_process "The modification of peptidyl-proline." [GOC:go_curators] EOG8NZX91 GO:0016301 1/64 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8NZX96 GO:0009103 15/95 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG8NZX96 GO:0016757 4/95 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8NZX96 GO:0005788 4/95 endoplasmic reticulum lumen cellular_component "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] EOG8NZX96 GO:0008475 1/95 procollagen-lysine 5-dioxygenase activity molecular_function "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] EOG8NZX96 GO:0005581 1/95 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8935Z7 GO:0051258 63/183 protein polymerization biological_process "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] EOG8935Z7 GO:0003924 63/183 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8935Z7 GO:0005874 63/183 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8935Z7 GO:0005525 63/183 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8935Z7 GO:0005200 63/183 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8935Z7 GO:0005737 62/183 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8935Z7 GO:0007017 61/183 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8935Z7 GO:0009987 3/183 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8935Z7 GO:0007052 2/183 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8935Z7 GO:0007094 2/183 mitotic spindle assembly checkpoint biological_process "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] EOG8935Z7 GO:0005819 1/183 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8935Z7 GO:0000902 1/183 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8935Z7 GO:0000235 1/183 astral microtubule cellular_component "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] EOG8935Z7 GO:0005813 1/183 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8935Z7 GO:0005524 1/183 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8935Z7 GO:0000281 1/183 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8935Z7 GO:0042626 1/183 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8935Z7 GO:0016021 1/183 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8935Z7 GO:0051298 1/183 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8935Z7 GO:0019730 1/183 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8935Z7 GO:0017022 1/183 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8935Z7 GO:0005811 1/183 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG812PNT GO:0030785 1/31 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] EOG83N9VW GO:0005634 95/339 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83N9VW GO:0003700 95/339 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG83N9VW GO:0043565 89/339 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83N9VW GO:0019101 1/339 female somatic sex determination biological_process "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] EOG83N9VW GO:0000398 1/339 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG83N9VW GO:0003677 1/339 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83N9VW GO:0007548 1/339 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG83N9VW GO:0045497 1/339 female analia development biological_process "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0001078 1/339 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG83N9VW GO:0008049 1/339 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG83N9VW GO:0045892 1/339 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046661 1/339 male sex differentiation biological_process "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0048086 1/339 negative regulation of developmental pigmentation biological_process "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] EOG83N9VW GO:0045433 1/339 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG83N9VW GO:0018993 1/339 somatic sex determination biological_process "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] EOG83N9VW GO:0006355 1/339 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0042803 1/339 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG83N9VW GO:0045893 1/339 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0048071 1/339 sex-specific pigmentation biological_process "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] EOG83N9VW GO:0045496 1/339 male analia development biological_process "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0007619 1/339 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83N9VW GO:0007283 1/339 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG83N9VW GO:0007417 1/339 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG83N9VW GO:0016199 1/339 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG83N9VW GO:0035215 1/339 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG83N9VW GO:0045944 1/339 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046872 1/339 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83N9VW GO:0003729 1/339 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG83N9VW GO:0045498 1/339 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG83N9VW GO:0005515 1/339 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83N9VW GO:0000122 1/339 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0007483 1/339 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG83N9VW GO:0001077 1/339 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG83N9VW GO:0007530 1/339 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG83N9VW GO:0007486 1/339 imaginal disc-derived female genitalia development biological_process "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0006357 1/339 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0019102 1/339 male somatic sex determination biological_process "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] EOG83N9VW GO:0007485 1/339 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0035263 1/339 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG83N9VW GO:0046660 1/339 female sex differentiation biological_process "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0045570 1/339 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG803081 GO:0003839 43/99 gamma-glutamylcyclotransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] EOG803081 GO:0006750 43/99 glutathione biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] EOG803081 GO:0005576 1/99 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG803081 GO:0042381 1/99 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8T1M2W GO:0016021 4/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T1M2W GO:0005328 4/16 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG81VNJG GO:0035556 6/50 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG81VNJG GO:0046872 6/50 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8T1M2S GO:0016021 30/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T1M2S GO:0006810 28/89 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8T1M2S GO:0005789 12/89 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8T1M2S GO:0009953 12/89 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8T1M2S GO:0000003 2/89 reproduction biological_process "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] EOG8T1M2S GO:0048193 2/89 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG8T1M2S GO:0005215 2/89 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8T1M2S GO:0048042 2/89 regulation of post-mating oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766] EOG8T1M2S GO:0006888 1/89 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG8T1M2S GO:0007030 1/89 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8T1M2S GO:0030554 1/89 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8T1M2S GO:0090263 1/89 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG8T1M2S GO:0070863 1/89 positive regulation of protein exit from endoplasmic reticulum biological_process "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah] EOG8T1M2S GO:0002121 1/89 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8T1M2S GO:0061357 1/89 positive regulation of Wnt protein secretion biological_process "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] EOG8T1M2S GO:0034389 1/89 lipid particle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] EOG8T1M2S GO:0035220 1/89 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8D2950 GO:0003723 24/121 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D2950 GO:0004000 23/121 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8D2950 GO:0006396 23/121 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8D2950 GO:0016491 9/121 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D2950 GO:0004032 2/121 alditol:NADP+ 1-oxidoreductase activity molecular_function "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] EOG8D2950 GO:0046872 1/121 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D2950 GO:0006400 1/121 tRNA modification biological_process "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] EOG8D2950 GO:0008251 1/121 tRNA-specific adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] EOG8D2950 GO:0008033 1/121 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG80306V GO:0008270 329/890 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80306V GO:0004181 329/890 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG80306V GO:0005319 8/890 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG80306V GO:0005615 3/890 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80306V GO:0007586 1/890 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG80306V GO:0022008 1/890 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG80306V GO:0031982 1/890 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG80306V GO:0004180 1/890 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG80306V GO:0005515 1/890 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80306V GO:0005576 1/890 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80306V GO:0016021 1/890 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80306V GO:0004930 1/890 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8D295N GO:0004519 7/42 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8D295N GO:0003964 7/42 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8D295N GO:0003723 6/42 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D295N GO:0046872 1/42 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DV81P GO:0005794 77/199 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8DV81P GO:0016021 77/199 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DV81P GO:0006486 77/199 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8DV81P GO:0008378 68/199 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8DV81P GO:0047915 9/199 ganglioside galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] EOG8DV81P GO:0008039 1/199 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8DV81P GO:0007030 1/199 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8T1M24 GO:0005506 15/66 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8T1M24 GO:0031418 15/66 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8T1M24 GO:0016706 14/66 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG8T1M24 GO:0016705 1/66 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8935ZZ GO:0008234 5/251 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8935ZZ GO:0015074 1/251 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8935ZZ GO:0003964 1/251 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8935ZZ GO:0003723 1/251 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8935ZZ GO:0003676 1/251 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XWJFC GO:0005549 2/52 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG80CKZ6 GO:0006744 19/45 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG80CKZ6 GO:0005743 1/45 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8VT8CH GO:0004419 26/77 hydroxymethylglutaryl-CoA lyase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407] EOG8VT8CH GO:0005875 1/77 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8JWXX4 GO:0008270 2/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D55BK GO:0005524 25/102 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D55BK GO:0004674 24/102 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8D55BK GO:0007165 23/102 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8D55BK GO:0004697 2/102 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8D55BK GO:0006468 1/102 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8D55BK GO:0016301 1/102 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8D55BK GO:0046777 1/102 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG8D55BK GO:0030054 1/102 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8D55BK GO:0090303 1/102 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8D55BK GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D55BK GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55BK GO:0016020 1/102 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8D55BK GO:0032154 1/102 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8D55BK GO:0030027 1/102 lamellipodium cellular_component "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] EOG8D55BK GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D55BK GO:0030496 1/102 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8D55BK GO:0007472 1/102 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8D55BK GO:0005856 1/102 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8D55BK GO:0031532 1/102 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8D55BK GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8D55BK GO:0007391 1/102 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8D55BK GO:0007049 1/102 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8D55BK GO:0004672 1/102 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8D55BK GO:0007155 1/102 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8D55BK GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D55BK GO:0003676 1/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D55BK GO:0051301 1/102 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8Z91CT GO:0043565 37/124 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z91CT GO:0003700 37/124 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z91CT GO:0005634 30/124 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z91CT GO:0032504 1/124 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8Z91CT GO:0005615 1/124 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z91CT GO:0030154 1/124 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8Z91CT GO:0007399 1/124 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8Z91CT GO:0006351 1/124 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG80P6ND GO:0016021 230/726 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6ND GO:0022891 177/726 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0022857 38/726 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0008643 18/726 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG80P6ND GO:0005886 18/726 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6ND GO:0015771 15/726 trehalose transport biological_process "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] EOG80P6ND GO:0015574 15/726 trehalose transmembrane transporter activity molecular_function "Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] EOG80P6ND GO:0032440 8/726 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG80P6ND GO:0016020 2/726 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80P6ND GO:0046427 1/726 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8PVRDQ GO:0004089 5/118 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8PVRDQ GO:0008270 4/118 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRDQ GO:0006730 4/118 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8WSZR4 GO:0003676 24/91 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WSZR4 GO:0004523 22/91 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8WSZR4 GO:0005524 1/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WSZR4 GO:0003723 1/91 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8WSZR4 GO:0003964 1/91 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8WSZR4 GO:0004386 1/91 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8H74SX GO:0005549 3/43 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8H74ST GO:0005622 1/4 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8H74ST GO:0006396 1/4 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8H74SR GO:0035556 25/94 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8H74SR GO:0007616 1/94 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8H74SR GO:0046426 1/94 negative regulation of JAK-STAT cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8H74SR GO:0043697 1/94 cell dedifferentiation biological_process "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] EOG8H74SR GO:0007482 1/94 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8H74SR GO:0048072 1/94 compound eye pigmentation biological_process "Establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG8H74SR GO:0046425 1/94 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG8H74SR GO:0008586 1/94 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8H74SR GO:0005942 1/94 phosphatidylinositol 3-kinase complex cellular_component "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] EOG8H74SR GO:0045873 1/94 negative regulation of sevenless signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] EOG8H74SR GO:0007298 1/94 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8H74SR GO:0030718 1/94 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8H74SR GO:0048802 1/94 notum morphogenesis biological_process "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] EOG8H74SR GO:0035014 1/94 phosphatidylinositol 3-kinase regulator activity molecular_function "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] EOG8H74SR GO:0045677 1/94 negative regulation of R7 cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8H74SR GO:0042059 1/94 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8DRCW7 GO:0022008 1/74 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8B8MV7 GO:0003743 25/83 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8B8MV7 GO:0046872 1/83 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8B8MV7 GO:0006413 1/83 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8B8MV7 GO:0016199 1/83 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8B8MV7 GO:0005850 1/83 eukaryotic translation initiation factor 2 complex cellular_component "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] EOG8B8MV7 GO:0005875 1/83 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8B8MV7 GO:0007052 1/83 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8B8MV7 GO:0000022 1/83 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8B8MV7 GO:0005829 1/83 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84F8QD GO:0003676 4/16 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84F8QD GO:0046872 3/16 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84F8QD GO:0005634 1/16 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84F8QD GO:0008270 1/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B8MVQ GO:0016020 27/89 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82JR5Q GO:0003676 2/37 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82JR5Q GO:0000166 2/37 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8HB10Z GO:0016740 2/151 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8HB10Z GO:0010378 1/151 temperature compensation of the circadian clock biological_process "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] EOG8HB10Z GO:0031514 1/151 motile cilium cellular_component "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8HB10Z GO:0060285 1/151 cilium-dependent cell motility biological_process "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] EOG8HB10Z GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HB10Z GO:0045433 1/151 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG8HB10Z GO:0035082 1/151 axoneme assembly biological_process "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] EOG8HB10Z GO:0030425 1/151 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8HB10Z GO:0007605 1/151 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG86MF0D GO:0016021 3/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86MF0D GO:0005886 3/16 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG86MF0D GO:0050909 3/16 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8PVRD3 GO:0097056 22/75 selenocysteinyl-tRNA(Sec) biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [CHEBI:13166, GOC:yaf, PMID:15317934, UniPathway:UPA00906] EOG8PVRD3 GO:0016785 22/75 transferase activity, transferring selenium-containing groups molecular_function "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8PVRD3 GO:0030170 21/75 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8PVRD3 GO:0016012 1/75 sarcoglycan complex cellular_component "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] EOG85XBCG GO:0004623 1/77 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG8BVV8D GO:0005319 1/3 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG876NDW GO:0004185 1/10 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8NKFB8 GO:0004089 104/367 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8NKFB8 GO:0006730 100/367 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8NKFB8 GO:0008270 99/367 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NKFB8 GO:0031233 1/367 intrinsic component of external side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] EOG876NDJ GO:0008812 3/15 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG876NDJ GO:0050660 3/15 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG876NDJ GO:0006066 3/15 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8GXJ25 GO:0016829 1/84 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8GXJ21 GO:0005549 3/25 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG89GNZ1 GO:0008270 2/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8T1M30 GO:0065007 1/34 biological regulation biological_process "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] EOG8T1M30 GO:0005179 1/34 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG86T5GG GO:0004252 12/41 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GXJ2Q GO:0043234 1/82 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8GXJ2Q GO:0071011 1/82 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8GXJ2Q GO:0022008 1/82 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8GXJ2Q GO:0010389 1/82 regulation of G2/M transition of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] EOG8GXJ2Q GO:0071013 1/82 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8GXJ2Q GO:0000398 1/82 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8GXJ2Q GO:0005515 1/82 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89S8QM GO:0003677 1/25 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DFS46 GO:0008236 25/62 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8DFS46 GO:0016020 24/62 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DFS46 GO:0016021 1/62 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DFS45 GO:0005789 25/116 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8DFS45 GO:0007029 25/116 endoplasmic reticulum organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] EOG8DFS45 GO:0022416 2/116 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8DFS45 GO:0016021 2/116 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DFS45 GO:0006887 2/116 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8DFS45 GO:0001555 2/116 oocyte growth biological_process "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] EOG8DFS45 GO:0051686 1/116 establishment of ER localization biological_process "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai] EOG8DFS45 GO:0008407 1/116 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8DFS45 GO:0007296 1/116 vitellogenesis biological_process "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] EOG8T7BKC GO:0005887 18/112 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T7BKC GO:0004952 18/112 dopamine neurotransmitter receptor activity molecular_function "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] EOG8T7BKC GO:0016021 10/112 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T7BKC GO:0004930 10/112 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8T7BKC GO:0004715 2/112 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8T7BKC GO:0042594 1/112 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8T7BKC GO:0008306 1/112 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG8T7BKC GO:0009744 1/112 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8T7BKC GO:0071329 1/112 cellular response to sucrose stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah] EOG8T7BKC GO:0090328 1/112 regulation of olfactory learning biological_process "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] EOG8T7BKC GO:0007612 1/112 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG8T7BKC GO:0001588 1/112 dopamine neurotransmitter receptor activity, coupled via Gs molecular_function "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260] EOG8T7BKC GO:0040040 1/112 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8T7BKC GO:0007212 1/112 dopamine receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] EOG8T7BKC GO:0007191 1/112 adenylate cyclase-activating dopamine receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling] EOG8T7BKC GO:0043052 1/112 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8T7BKC GO:0008542 1/112 visual learning biological_process "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] EOG8T7BKC GO:0007613 1/112 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG83BQ5H GO:0016020 2/21 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83BQ5H GO:0000155 2/21 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG83BQ5H GO:0005249 2/21 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8QZB47 GO:0008270 5/36 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DBWWW GO:0004930 5/50 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DBWWW GO:0016021 5/50 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWWW GO:0016301 4/50 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8DBWWW GO:0005524 3/50 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DBWWW GO:0046872 1/50 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DBWWW GO:0003676 1/50 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DBWWW GO:0005525 1/50 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8ZKN35 GO:0052689 2/163 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG86X1R2 GO:0005840 4/87 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG86X1R2 GO:0003735 1/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG86X1R2 GO:0005762 1/87 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG86X1R2 GO:0006412 1/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG87H84S GO:0003677 2/10 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87H84S GO:0006355 2/10 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG87H84S GO:0003676 1/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87H84S GO:0008270 1/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8KWN8B GO:0006744 27/93 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8KWN8B GO:0055114 26/93 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8KWN8B GO:0016491 1/93 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8NW20X GO:0035556 22/96 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8NW20X GO:0016021 22/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW20X GO:0000166 22/96 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NW20X GO:0016849 13/96 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8NW20X GO:0009190 13/96 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8NW20X GO:0004383 9/96 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG8NW20X GO:0006182 1/96 cGMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] EOG8NW20T GO:0005549 46/70 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NW20T GO:0004984 46/70 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8NW20T GO:0016021 45/70 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW20T GO:0004930 44/70 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NW20T GO:0005886 42/70 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NW20T GO:0016020 1/70 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NW20T GO:0019236 1/70 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8NW20T GO:0016503 1/70 pheromone receptor activity molecular_function "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [CHEBI:26013, GOC:hjd, ISBN:0198506732] EOG8NW20T GO:0007619 1/70 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8X0Q6Z GO:0046872 23/128 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X0Q6Z GO:0003676 6/128 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X0Q6Z GO:0005634 6/128 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X0Q6Z GO:0003723 1/128 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8X0Q6Z GO:0001522 1/128 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG8X0Q6Z GO:0009982 1/128 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG8BS00N GO:0016021 46/215 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BS00N GO:0015377 45/215 cation:chloride symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] EOG8BS00N GO:0016020 21/215 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BS00N GO:0055085 20/215 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8BS00N GO:0015171 2/215 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8BS00N GO:0005215 2/215 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8BS00N GO:0003333 2/215 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8BS00N GO:0006811 2/215 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8BS00N GO:1902476 1/215 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG8BS00N GO:0008511 1/215 sodium:potassium:chloride symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] EOG8BS00N GO:0006821 1/215 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8BS00N GO:0005886 1/215 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BS00N GO:0035826 1/215 rubidium ion transport biological_process "The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:49847, GOC:yaf] EOG8BS00N GO:0006813 1/215 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG87H840 GO:0004602 4/37 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG87H840 GO:0006979 4/37 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG87H840 GO:0003700 1/37 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG87H840 GO:0043565 1/37 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8FTZGP GO:0006412 26/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8FTZGP GO:0003735 26/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8FTZGP GO:0005840 25/87 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8FTZGP GO:0005762 1/87 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8BS00G GO:0005549 5/25 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8BS00G GO:0005886 5/25 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BS00G GO:0016021 5/25 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BS00G GO:0004984 5/25 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8BS00G GO:0004930 5/25 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8F7QZX GO:0005549 13/36 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8F7QZX GO:0005886 13/36 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8F7QZX GO:0004930 13/36 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8F7QZX GO:0004984 13/36 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8F7QZX GO:0016021 13/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V71Z2 GO:0007165 5/39 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG84N193 GO:0035556 2/27 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8XSP3N GO:0008061 250/966 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005576 250/966 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP3N GO:0006030 246/966 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0004252 27/966 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8XSP3N GO:0005044 26/966 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG8XSP3N GO:0016020 24/966 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XSP3N GO:0006032 4/966 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005975 4/966 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8XSP3N GO:0004568 4/966 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8XSP3N GO:0006955 2/966 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8XSP3N GO:0030247 2/966 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG8XSP3N GO:0030246 2/966 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8XSP3N GO:0006508 1/966 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8XSP3N GO:0007616 1/966 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8XSP3N GO:0004190 1/966 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8XSP3N GO:0007614 1/966 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8X0Q7N GO:0008270 1/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X0Q7N GO:0003676 1/20 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R52K6 GO:0006351 5/31 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8R52K6 GO:0005634 5/31 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8R52K6 GO:0043565 5/31 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8R52K6 GO:0008270 5/31 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R52K6 GO:0003700 5/31 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8ZSCM0 GO:0005634 22/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZSCM0 GO:0030915 22/88 Smc5-Smc6 complex cellular_component "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] EOG8ZSCM0 GO:0006281 22/88 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8FR35K GO:0005576 6/150 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FR35K GO:0055114 1/150 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8FR35K GO:0016117 1/150 carotenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] EOG84QWDR GO:0007615 1/103 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG84QWDR GO:0048789 1/103 cytoskeletal matrix organization at active zone biological_process "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759] EOG84QWDR GO:0008344 1/103 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG84QWDR GO:0007274 1/103 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG84QWDR GO:0048790 1/103 maintenance of presynaptic active zone structure biological_process "The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] EOG84QWDR GO:0007614 1/103 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG84QWDR GO:0007268 1/103 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG84QWDR GO:0031594 1/103 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG84QWDR GO:0048786 1/103 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG84QWDR GO:0007269 1/103 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG84QWDR GO:0048167 1/103 regulation of synaptic plasticity biological_process "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] EOG84QWDR GO:0032440 1/103 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG84QWDR GO:0048788 1/103 cytoskeleton of presynaptic active zone cellular_component "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438] EOG8NW21K GO:0003723 24/86 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NW21K GO:0000178 23/86 exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases." [PMID:10465791] EOG8NW21K GO:0035327 1/86 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8NW21K GO:0010468 1/86 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8NW21K GO:0000176 1/86 nuclear exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] EOG8NW21K GO:0005737 1/86 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NW21K GO:0016787 1/86 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8KH5BP GO:0032259 19/59 methylation biological_process "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] EOG8KH5BP GO:0005845 19/59 mRNA cap binding complex cellular_component "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] EOG8KH5BP GO:0003723 19/59 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8KH5BP GO:0046331 1/59 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8NGK4D GO:0005328 2/21 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8NGK4D GO:0016021 2/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D81M0 GO:0005524 24/84 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D81M0 GO:0043141 24/84 ATP-dependent 5'-3' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] EOG8D81M0 GO:0042127 3/84 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8D81M0 GO:0006355 3/84 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D81M0 GO:0006310 3/84 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8D81M0 GO:0031011 3/84 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG8D81M0 GO:0006281 3/84 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8D81M0 GO:0030111 3/84 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8D81M0 GO:0006351 3/84 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8D81M0 GO:0003713 3/84 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8D81M0 GO:0007049 2/84 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8D81M0 GO:0016568 2/84 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8D81M0 GO:0051301 2/84 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8D81M0 GO:0005634 1/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D81M0 GO:0005515 1/84 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D81M0 GO:0005875 1/84 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8D81M0 GO:0090307 1/84 mitotic spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw] EOG8D81M0 GO:0010628 1/84 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8D81M0 GO:0043486 1/84 histone exchange biological_process "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] EOG8D81M0 GO:0035267 1/84 NuA4 histone acetyltransferase complex cellular_component "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] EOG8D81M0 GO:0007095 1/84 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8D81M0 GO:0035060 1/84 brahma complex cellular_component "A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982] EOG8D81M0 GO:0016573 1/84 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8D81M2 GO:0016013 1/109 syntrophin complex cellular_component "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] EOG8D81M2 GO:0008092 1/109 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG8D81M2 GO:0008582 1/109 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8KH5BG GO:0000166 18/111 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8KH5BG GO:0003676 16/111 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KH5BG GO:0046872 7/111 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C8B7M GO:0016021 24/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D81MM GO:0016491 49/162 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D81MM GO:0004316 1/162 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8D81MM GO:0005811 1/162 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8D81MC GO:0032312 28/95 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8D81MC GO:0008270 28/95 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81MC GO:0008060 28/95 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8D81MC GO:0043547 1/95 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8VT8B2 GO:0004001 38/108 adenosine kinase activity molecular_function "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] EOG8VT8B2 GO:0006166 38/108 purine ribonucleoside salvage biological_process "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] EOG8VT8B2 GO:0016773 27/108 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8VT8B2 GO:0008270 1/108 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VT8B0 GO:0046872 11/68 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VT8B0 GO:0003676 2/68 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VT8B0 GO:0008270 1/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C8B7S GO:0003700 8/63 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8C8B7S GO:0043565 8/63 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8C8B7S GO:0046983 2/63 protein dimerization activity molecular_function "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] EOG8D2963 GO:0007275 1/18 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8D2963 GO:0005634 1/18 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D2963 GO:0006355 1/18 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D2963 GO:0003677 1/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZSCMQ GO:0004386 1/2 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8ZSCMQ GO:0003676 1/2 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZSCMQ GO:0005524 1/2 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8B8MWF GO:0045454 55/184 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8B8MWF GO:0006662 55/184 glycerol ether metabolic process biological_process "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732] EOG8B8MWF GO:0015035 55/184 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8B8MWF GO:0006974 2/184 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8B8MWF GO:0016853 1/184 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG88972C GO:0016021 28/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88972C GO:0006810 22/94 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG88972C GO:0055085 5/94 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG88972C GO:0005811 1/94 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG88972C GO:0005739 1/94 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG88972C GO:0006843 1/94 mitochondrial citrate transport biological_process "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai] EOG88972C GO:0016006 1/94 Nebenkern cellular_component "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] EOG88972C GO:0015746 1/94 citrate transport biological_process "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8NKF8B GO:0005319 30/134 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG8NKF8B GO:0005576 1/134 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF8B GO:0006629 1/134 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8NKF8B GO:0015918 1/134 sterol transport biological_process "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] EOG8NKF8B GO:0005875 1/134 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NKF8B GO:0034196 1/134 acylglycerol transport biological_process "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl] EOG8NKF8B GO:0003700 1/134 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NKF8B GO:0045178 1/134 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8NKF8B GO:0043565 1/134 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NKF8B GO:0004806 1/134 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG8NKF8B GO:0005615 1/134 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8RR8X7 GO:0016021 11/154 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGFN GO:0003677 2/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FFGFN GO:0046872 2/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FFGFN GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FFGFN GO:0008270 1/103 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8P2SJR GO:0005509 2/13 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG86MF1J GO:0016021 1/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86MF1J GO:0008146 1/13 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8CJXZ4 GO:0005874 23/71 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8CJXZ4 GO:0005524 23/71 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CJXZ4 GO:0007018 23/71 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8CJXZ4 GO:0005871 23/71 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8CJXZ4 GO:0003777 23/71 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8CJXZ4 GO:0004871 7/71 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8CJXZ4 GO:0007186 7/71 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8CJXZ4 GO:0005834 7/71 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG8CJXZ4 GO:0050113 1/71 inositol oxygenase activity molecular_function "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699] EOG8CJXZ4 GO:0003676 1/71 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CJXZ4 GO:0008152 1/71 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8CJXZ4 GO:0005737 1/71 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CJXZ4 GO:0005506 1/71 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8CJXZ4 GO:0019310 1/71 inositol catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators] EOG8S7N6K GO:0000166 1/33 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8QJV2H GO:0003676 5/23 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV2H GO:0046872 1/23 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG854CDM GO:0005544 89/289 calcium-dependent phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] EOG854CDM GO:0005509 89/289 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG854CDM GO:0003779 3/289 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG854CDM GO:0061467 1/289 basolateral protein localization biological_process "Any process in which a protein is transported to, or maintained in, basolateral regions of the cell." [GOC:dph] EOG854CDM GO:0003677 1/289 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG854CDM GO:0006351 1/289 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG854CDM GO:0048190 1/289 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG854CDM GO:0007155 1/289 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG854CDM GO:0030011 1/289 maintenance of cell polarity biological_process "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG854CDM GO:0008360 1/289 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG854CDM GO:0030507 1/289 spectrin binding molecular_function "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] EOG854CDM GO:0046872 1/289 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG854CDM GO:0010797 1/289 regulation of multivesicular body size involved in endosome transport biological_process "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] EOG854CDM GO:0032509 1/289 endosome transport via multivesicular body sorting pathway biological_process "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] EOG854CDM GO:0005515 1/289 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG854CDM GO:0005634 1/289 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG854CDM GO:0016020 1/289 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG854CDM GO:0012505 1/289 endomembrane system cellular_component "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] EOG854CDM GO:0005938 1/289 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG854CDM GO:0006357 1/289 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8F4VQV GO:0005524 3/138 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F4VQV GO:0004674 2/138 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8F4VQV GO:0032440 1/138 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8F4VQV GO:0004672 1/138 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8F4VQV GO:0016772 1/138 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8S7N63 GO:0016021 6/38 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N63 GO:0016286 6/38 small conductance calcium-activated potassium channel activity molecular_function "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] EOG86MF19 GO:0000387 24/85 spliceosomal snRNP assembly biological_process "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] EOG86MF19 GO:0005829 1/85 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG86MF19 GO:0005634 1/85 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86MF19 GO:0005856 1/85 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8C5FZ8 GO:0022008 1/89 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C5FZ8 GO:0016020 1/89 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8C5FZ8 GO:0016887 1/89 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8C5FZ8 GO:0005524 1/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T1M1D GO:0005524 24/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T1M1D GO:0004672 21/97 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8T1M1D GO:0004674 3/97 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8T1M1D GO:0004725 1/97 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8T1M1D GO:0046621 1/97 negative regulation of organ growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8T1M1D GO:0035094 1/97 response to nicotine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] EOG8T1M1D GO:0005840 1/97 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8T1M1D GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T1M1D GO:0003735 1/97 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8T1M1D GO:0046872 1/97 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8T1M1D GO:0045471 1/97 response to ethanol biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] EOG8T1M1D GO:0023014 1/97 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8T1M1D GO:0030707 1/97 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8T1M1D GO:0042220 1/97 response to cocaine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl] EOG8T1M1D GO:0035332 1/97 positive regulation of hippo signaling biological_process "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf] EOG8T1M1D GO:0048036 1/97 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8T1M1D GO:0045807 1/97 positive regulation of endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8T1M1D GO:0006414 1/97 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8T1M1D GO:0004697 1/97 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8T1M1D GO:0016319 1/97 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8T1M1D GO:0006468 1/97 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8T1M1D GO:0006915 1/97 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8T1M1D GO:0005886 1/97 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8T1M1D GO:0004702 1/97 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8T1M1D GO:0045178 1/97 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8T1M1D GO:0035329 1/97 hippo signaling biological_process "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423] EOG81VNKN GO:0043565 4/30 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG81VNKN GO:0006351 4/30 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG81VNKN GO:0005634 4/30 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81VNKN GO:0003700 4/30 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81VNKN GO:0003707 4/30 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG81VNKN GO:0008270 4/30 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82JR57 GO:0004674 2/45 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG82JR57 GO:0005524 2/45 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82JR57 GO:0005875 1/45 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG82JR57 GO:0006468 1/45 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG82JR57 GO:0005200 1/45 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG82JR57 GO:0051493 1/45 regulation of cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] EOG82JR57 GO:0030018 1/45 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG82JR57 GO:0048739 1/45 cardiac muscle fiber development biological_process "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] EOG82JR57 GO:0004683 1/45 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG82JR57 GO:0051015 1/45 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG82JR57 GO:0030334 1/45 regulation of cell migration biological_process "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] EOG82JR57 GO:0004687 1/45 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8FFGH2 GO:0005524 27/85 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FFGH2 GO:0051085 27/85 chaperone mediated protein folding requiring cofactor biological_process "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] EOG8FFGH2 GO:0017111 7/85 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8FFGH2 GO:0043104 1/85 positive regulation of GTP cyclohydrolase I activity biological_process "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] EOG8FFGH2 GO:0040011 1/85 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8FFGH2 GO:0048085 1/85 adult chitin-containing cuticle pigmentation biological_process "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8FFGH2 GO:0005783 1/85 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8FFGH2 GO:0042053 1/85 regulation of dopamine metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] EOG8FFGH2 GO:0005788 1/85 endoplasmic reticulum lumen cellular_component "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] EOG85F03R GO:0006030 7/25 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG85F03R GO:0005576 7/25 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85F03R GO:0008061 7/25 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG85F03R GO:0005975 3/25 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG89S8PM GO:0008289 1/13 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8GXJ3G GO:0016020 24/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GXJ3G GO:0022008 1/79 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8GXJ3G GO:0042331 1/79 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8GXJ3G GO:0002168 1/79 instar larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8GXJ3G GO:0033617 1/79 mitochondrial respiratory chain complex IV assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah] EOG8GXJ3G GO:0016021 1/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GXJ3G GO:0005743 1/79 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8GXJ3G GO:0009060 1/79 aerobic respiration biological_process "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] EOG8GXJ3G GO:0007632 1/79 visual behavior biological_process "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] EOG86DPH1 GO:0016020 41/95 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG86DPH1 GO:0030247 31/95 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG86DPH1 GO:0005044 31/95 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG86DPH1 GO:0006955 31/95 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG86DPH1 GO:0006909 1/95 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG86DPH1 GO:0050829 1/95 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG86DPH1 GO:0009617 1/95 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG86DPH1 GO:0006898 1/95 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG8QC3N1 GO:0042073 24/80 intraciliary transport biological_process "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374] EOG8QC3N1 GO:0042384 1/80 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8Z91B7 GO:0005887 1/100 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKFCB GO:0016021 2/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83BQ4D GO:0008146 43/146 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG83BQ4D GO:0008459 4/146 chondroitin 6-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] EOG83BQ4D GO:0016740 1/146 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8KD93T GO:0016020 24/105 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8KD93T GO:0016021 5/105 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89PDDN GO:0005622 26/130 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89PDDN GO:0046872 23/130 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89PDDN GO:0035556 23/130 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG89PDDN GO:0007165 3/130 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG89PDDN GO:0030414 2/130 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG89PDDN GO:0005576 2/130 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG89PDDN GO:0016337 1/130 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG89PDDN GO:0007480 1/130 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG89PDDN GO:0043408 1/130 regulation of MAPK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] EOG89PDDN GO:0048749 1/130 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG89PDDN GO:0034334 1/130 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG83BQ4M GO:0005085 6/45 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG83BQ4M GO:0007264 6/45 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG866Z22 GO:0046872 1/9 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG866Z2N GO:0005525 24/61 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG866Z2N GO:0007264 24/61 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG866Z2N GO:0015031 2/61 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG866Z2N GO:0006412 1/61 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG866Z2N GO:0005840 1/61 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG866Z2N GO:0003735 1/61 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG866Z2N GO:0045202 1/61 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG89PDD6 GO:0004252 2/7 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8QC3NP GO:0005549 19/69 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8QC3NP GO:0005576 1/69 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QC3NP GO:0007606 1/69 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG87SVX1 GO:0004222 2/23 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG87SVX1 GO:0008270 2/23 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83BQ48 GO:0016021 24/57 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83BQ48 GO:0007476 1/57 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG83BQ48 GO:0008805 1/57 carbon-monoxide oxygenase activity molecular_function "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] EOG83BQ48 GO:0007613 1/57 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG83BQ48 GO:0007626 1/57 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8KD932 GO:0006030 20/42 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8KD932 GO:0008061 20/42 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8KD932 GO:0005576 20/42 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG82RGRJ GO:0005576 18/34 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG82RGRJ GO:0005184 1/34 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG82RGRJ GO:0007218 1/34 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG82RGRJ GO:0005615 1/34 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG82RGRJ GO:0097005 1/34 adipokinetic hormone receptor binding molecular_function "Interacting selectively and non-covalently with an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG8642TP GO:0016021 25/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8642TP GO:0015266 1/84 protein channel activity molecular_function "Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [GOC:rb] EOG8642TP GO:0045039 1/84 protein import into mitochondrial inner membrane biological_process "The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008] EOG8642TP GO:0042721 1/84 mitochondrial inner membrane protein insertion complex cellular_component "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765] EOG8Z91BM GO:0005272 54/138 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8Z91BM GO:0016021 53/138 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z91BM GO:0051536 2/138 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8Z91BM GO:0004252 2/138 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8Z91BM GO:0016020 1/138 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z91BM GO:0000439 1/138 core TFIIH complex cellular_component "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] EOG8Z91BM GO:0006289 1/138 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8Z91BM GO:0006355 1/138 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG80P6MN GO:0005509 19/70 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG80P6MN GO:0007219 1/70 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG80P6MN GO:0005112 1/70 Notch binding molecular_function "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] EOG80P6MN GO:0009986 1/70 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG80P6MN GO:0003015 1/70 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG84J4XZ GO:0015991 77/236 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG84J4XZ GO:0015078 74/236 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG84J4XZ GO:0000220 70/236 vacuolar proton-transporting V-type ATPase, V0 domain cellular_component "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] EOG84J4XZ GO:0033179 7/236 proton-transporting V-type ATPase, V0 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG84J4XZ GO:0008553 3/236 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] EOG84J4XZ GO:0016787 3/236 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG84J4XZ GO:0046961 2/236 proton-transporting ATPase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] EOG84J4XZ GO:0007165 1/236 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG84J4XZ GO:0005516 1/236 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG84J4XZ GO:0045202 1/236 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG84J4XZ GO:0005886 1/236 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84J4XZ GO:0033181 1/236 plasma membrane proton-transporting V-type ATPase complex cellular_component "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] EOG84J4XZ GO:0051452 1/236 intracellular pH reduction biological_process "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] EOG84J4XZ GO:0009416 1/236 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG84J4XZ GO:0008021 1/236 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG84J4XZ GO:0005769 1/236 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG84J4XZ GO:0009881 1/236 photoreceptor activity molecular_function "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] EOG8MD0FN GO:0007156 3/51 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8MD0FN GO:0016021 3/51 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MD0FN GO:0005509 3/51 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8MD0FN GO:0005886 3/51 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FFGHB GO:0006950 26/583 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8FFGHB GO:0005212 9/583 structural constituent of eye lens molecular_function "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] EOG8FFGHB GO:0008340 3/583 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8FFGHB GO:0005875 3/583 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8FFGHB GO:0010998 2/583 regulation of translational initiation by eIF2 alpha phosphorylation biological_process "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] EOG8FFGHB GO:0009631 2/583 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG8FFGHB GO:0005515 2/583 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FFGHB GO:0007275 1/583 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FFGHB GO:0017022 1/583 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8FFGHB GO:0042595 1/583 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8FFGHB GO:0009408 1/583 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8FFGHB GO:0007476 1/583 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FFGHB GO:0010506 1/583 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8FFGHB GO:0003779 1/583 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8FFGHB GO:0006497 1/583 protein lipidation biological_process "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] EOG8FFGHB GO:0001666 1/583 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8FFGHB GO:0006979 1/583 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8FFGHB GO:0031427 1/583 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FFGHB GO:0050832 1/583 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8FFGHB GO:0042742 1/583 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG80P6MT GO:0003676 19/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80P6MT GO:0046872 19/89 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80P6MT GO:0016568 2/89 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG80P6MT GO:0006351 2/89 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG80P6MT GO:0005634 2/89 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80P6MT GO:0045944 1/89 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80P6MT GO:0007424 1/89 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG80P6MT GO:0007476 1/89 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG80P6MT GO:0007479 1/89 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG80P6MT GO:0007298 1/89 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG80P6MT GO:0007417 1/89 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG80P6MT GO:0007411 1/89 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG80P6MT GO:0035098 1/89 ESC/E(Z) complex cellular_component "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] EOG80P6MT GO:0007474 1/89 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG80P6MT GO:0008347 1/89 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG80P6MT GO:0006355 1/89 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG80P6MT GO:0042246 1/89 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG80P6MT GO:0007382 1/89 specification of segmental identity, maxillary segment biological_process "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] EOG80P6MT GO:0035091 1/89 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG80P6MT GO:0007418 1/89 ventral midline development biological_process "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] EOG80P6MT GO:0000122 1/89 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8WWV0B GO:0097157 4/52 pre-mRNA intronic binding molecular_function "Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624] EOG8WWV0B GO:0005681 4/52 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8WWV0B GO:0000398 4/52 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG86T5H0 GO:0005789 28/70 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG86T5H0 GO:0016021 28/70 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86T5H0 GO:0006506 28/70 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG86T5H0 GO:0016740 1/70 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8NW21S GO:0071011 1/82 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8NW21S GO:0000398 1/82 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8NW21S GO:0071013 1/82 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8BS01Z GO:0007165 1/42 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8MSGC0 GO:0004601 52/183 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8MSGC0 GO:0006979 52/183 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8MSGC0 GO:0020037 52/183 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8MSGC0 GO:0060967 1/183 negative regulation of gene silencing by RNA biological_process "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] EOG8MSGC0 GO:0016758 1/183 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8MSGC0 GO:0070189 1/183 kynurenine metabolic process biological_process "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph] EOG8MSGC0 GO:0005764 1/183 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8MSGC0 GO:1901216 1/183 positive regulation of neuron death biological_process "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] EOG8MSGC0 GO:0006727 1/183 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8FTZFJ GO:0016020 24/136 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FTZFJ GO:0016200 1/136 synaptic target attraction biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] EOG8FTZFJ GO:0007156 1/136 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8FTZFJ GO:0007413 1/136 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8FTZFJ GO:0007411 1/136 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FTZFJ GO:0030707 1/136 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FTZFJ GO:0005920 1/136 smooth septate junction cellular_component "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] EOG8FTZFJ GO:0007476 1/136 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FTZFJ GO:0007611 1/136 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8FTZFJ GO:0008355 1/136 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8FTZFJ GO:0008039 1/136 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8FTZFJ GO:0016021 1/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FTZFJ GO:0016323 1/136 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8FTZFJ GO:0031594 1/136 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8FTZFJ GO:0004252 1/136 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8FTZFJ GO:0016328 1/136 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG8FTZFJ GO:0005918 1/136 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8FTZFJ GO:0005886 1/136 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FTZFK GO:0003676 18/140 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZFK GO:0046872 18/140 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DFS51 GO:0016020 8/51 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DFS51 GO:0008237 8/51 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8DFS51 GO:0008241 8/51 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8NW21G GO:0016021 29/67 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW21G GO:0004983 27/67 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8NW21G GO:0004930 2/67 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NW21G GO:0007194 1/67 negative regulation of adenylate cyclase activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] EOG8NW21G GO:0004995 1/67 tachykinin receptor activity molecular_function "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] EOG8NW21G GO:0042263 1/67 neuropeptide F receptor activity molecular_function "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021] EOG8NW21G GO:0030536 1/67 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8NW21G GO:0007218 1/67 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8NW21G GO:0050254 1/67 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8NW21G GO:0005887 1/67 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW21G GO:0006950 1/67 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8NW21G GO:0007217 1/67 tachykinin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] EOG8NW21G GO:0008188 1/67 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8NW21G GO:0007186 1/67 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8NW21H GO:0003677 23/84 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NW21H GO:0008168 23/84 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8NW21H GO:0006306 23/84 DNA methylation biological_process "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] EOG8NW21H GO:0003886 2/84 DNA (cytosine-5-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] EOG8NW21H GO:0004379 2/84 glycylpeptide N-tetradecanoyltransferase activity molecular_function "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] EOG8NW21H GO:0090116 1/84 C-5 methylation of cytosine biological_process "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8NW21H GO:0000723 1/84 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8NW21H GO:0030488 1/84 tRNA methylation biological_process "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] EOG8NW21H GO:0008175 1/84 tRNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] EOG8NW21H GO:0009408 1/84 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8NW21H GO:0044026 1/84 DNA hypermethylation biological_process "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/] EOG8NW21H GO:0045089 1/84 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8NW21H GO:0010494 1/84 cytoplasmic stress granule cellular_component "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] EOG8NW21H GO:0008340 1/84 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8NW21H GO:0016363 1/84 nuclear matrix cellular_component "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] EOG8NW21H GO:0006979 1/84 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8NW21H GO:0002230 1/84 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG8NW21H GO:0043045 1/84 DNA methylation involved in embryo development biological_process "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111] EOG8NW21H GO:0005634 1/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NW21H GO:0016458 1/84 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG8BS01G GO:0016021 2/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BS01G GO:0016051 2/13 carbohydrate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] EOG8BS01G GO:0008146 2/13 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8FTZFC GO:0008270 1/18 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZFC GO:0003676 1/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BS01B GO:0005215 139/496 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8BS01B GO:0005622 138/496 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8BS01B GO:0016787 14/496 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BS01B GO:0005811 1/496 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8FTZFG GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89W4VM GO:0005524 27/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89W4VM GO:0006457 26/95 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG89W4VM GO:0005737 25/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89W4VM GO:0044267 1/95 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG89W4VM GO:0006200 1/95 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG89W4VM GO:0007052 1/95 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG89W4VM GO:0005875 1/95 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG89W4VM GO:0022008 1/95 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG89W4VM GO:0005832 1/95 chaperonin-containing T-complex cellular_component "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] EOG89W4VM GO:0042623 1/95 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG89W4VJ GO:0016021 22/239 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89W4VJ GO:0022891 15/239 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG89W4VJ GO:0022857 6/239 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG89W4VJ GO:0008643 1/239 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8J13R9 GO:0000166 23/89 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8J13R9 GO:0003676 22/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J13R9 GO:0003729 1/89 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8B0141 GO:0008612 26/90 peptidyl-lysine modification to peptidyl-hypusine biological_process "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] EOG8B0141 GO:0050983 3/90 deoxyhypusine biosynthetic process from spermidine biological_process "The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN] EOG8B0141 GO:0034038 3/90 deoxyhypusine synthase activity molecular_function "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pde, MetaCyc:2.5.1.46-RXN] EOG89W4V5 GO:0004252 10/46 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8J13RP GO:0005840 27/75 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8J13RP GO:0003735 27/75 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8J13RP GO:0006412 26/75 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8J13RP GO:0006417 12/75 regulation of translation biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8J13RP GO:0042127 12/75 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8J13RP GO:0043022 12/75 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8J13RP GO:0007275 11/75 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8J13RP GO:0006364 11/75 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8J13RP GO:0000461 1/75 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biological_process "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] EOG8J13RP GO:0048542 1/75 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8J13RP GO:0042274 1/75 ribosomal small subunit biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] EOG8J13RP GO:0000447 1/75 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biological_process "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] EOG8J13RP GO:0022627 1/75 cytosolic small ribosomal subunit cellular_component "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] EOG8J13RP GO:0006414 1/75 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8TMTG5 GO:0016021 41/138 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTG5 GO:0004930 24/138 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8TMTG5 GO:0004997 16/138 thyrotropin-releasing hormone receptor activity molecular_function "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] EOG8TMTG5 GO:0005887 1/138 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTG5 GO:0007218 1/138 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8TMTG5 GO:0008227 1/138 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8TMTG5 GO:0042654 1/138 ecdysis-triggering hormone receptor activity molecular_function "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] EOG8TMTG5 GO:0009755 1/138 hormone-mediated signaling pathway biological_process "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] EOG8TMTG5 GO:0022008 1/138 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8TMTG5 GO:0007186 1/138 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8TMTG5 GO:0008188 1/138 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8TMTG5 GO:0048812 1/138 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8TMTG5 GO:0008528 1/138 G-protein coupled peptide receptor activity molecular_function "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] EOG86T5HW GO:0005681 11/34 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG86T5HW GO:0000398 11/34 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG86T5HW GO:0019013 2/34 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG86T5HW GO:0003723 1/34 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG86T5HW GO:0071011 1/34 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG86T5HW GO:0005634 1/34 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86T5HW GO:0071013 1/34 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG86T5HW GO:0030532 1/34 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8NW216 GO:0006909 1/75 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8BS015 GO:0016791 2/16 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8KSS0N GO:0006207 29/92 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG8KSS0N GO:0006222 28/92 UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] EOG8KSS0N GO:0004158 28/92 dihydroorotate oxidase activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444] EOG8KSS0N GO:0016020 27/92 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8KSS0N GO:0004152 2/92 dihydroorotate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076] EOG8KSS0N GO:0005743 1/92 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8KSS0N GO:0044205 1/92 'de novo' UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] EOG8KSS0N GO:0005758 1/92 mitochondrial intermembrane space cellular_component "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] EOG8KSS0N GO:0016021 1/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KSS0N GO:0052888 1/92 obsolete OBSOLETE:dihydroorotate oxidase (fumarate) activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [EC:1.3.98.1, RHEA:30062] EOG8F4VRW GO:0016491 5/67 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F4VRW GO:0016301 1/67 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8MSGCK GO:0005975 2/4 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8MSGCK GO:0006032 2/4 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8MSGCK GO:0004568 2/4 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG87H858 GO:0045893 21/81 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG87H858 GO:0006351 21/81 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG87H858 GO:0071819 21/81 DUBm complex cellular_component "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473] EOG87H858 GO:0016578 21/81 histone deubiquitination biological_process "The modification of histones by removal of ubiquitin groups." [GOC:ai] EOG87H858 GO:0008270 21/81 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87H858 GO:0000124 21/81 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG87H858 GO:0005737 14/81 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87H858 GO:0015031 14/81 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG87H858 GO:0005643 14/81 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG87H858 GO:0016568 14/81 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG87H858 GO:0006406 14/81 mRNA export from nucleus biological_process "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] EOG87H858 GO:0030374 14/81 ligand-dependent nuclear receptor transcription coactivator activity molecular_function "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] EOG87H858 GO:0003713 7/81 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG87H858 GO:0005634 4/81 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87H858 GO:0006325 1/81 chromatin organization biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] EOG87H858 GO:0005515 1/81 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87H858 GO:0007412 1/81 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG87H858 GO:0008347 1/81 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG87H858 GO:0051726 1/81 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG87H858 GO:0006355 1/81 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8MPM68 GO:0005549 4/54 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8R26BZ GO:0007186 5/31 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8R26BZ GO:0003924 5/31 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8R26BZ GO:0004871 5/31 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8R26BZ GO:0019001 5/31 guanyl nucleotide binding molecular_function "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8R26BJ GO:0015991 65/111 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8R26BJ GO:0015078 65/111 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8R26BJ GO:0033179 63/111 proton-transporting V-type ATPase, V0 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG8R26BJ GO:0016787 5/111 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R26BJ GO:0000220 2/111 vacuolar proton-transporting V-type ATPase, V0 domain cellular_component "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] EOG8R26BJ GO:0033181 1/111 plasma membrane proton-transporting V-type ATPase complex cellular_component "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] EOG8R26BJ GO:0005886 1/111 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87Q0NW GO:0006457 25/72 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG87Q0NW GO:0016272 25/72 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG80KBGK GO:0005509 3/14 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8BVVBV GO:0046872 1/9 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DBWTJ GO:0005549 8/45 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8DBWTJ GO:0004984 8/45 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8DBWTJ GO:0016021 7/45 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWTJ GO:0004930 7/45 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DBWTJ GO:0005886 7/45 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8DBWTJ GO:0016020 1/45 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG87Q0P0 GO:0006355 3/24 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG87Q0P0 GO:0005634 3/24 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87H85J GO:0070822 1/107 Sin3-type complex cellular_component "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] EOG89W4X8 GO:0016021 28/112 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2GQ GO:0042302 1098/2997 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8XH2GQ GO:0031012 32/2997 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8XH2GQ GO:0040003 31/2997 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8XH2GQ GO:0008010 31/2997 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8XH2GQ GO:0022008 2/2997 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8XH2GQ GO:0008011 2/2997 structural constituent of pupal chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8XH2GQ GO:0032504 1/2997 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8XH2GQ GO:0048058 1/2997 compound eye corneal lens development biological_process "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid] EOG8XH2GQ GO:0005615 1/2997 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8XH2GQ GO:0005212 1/2997 structural constituent of eye lens molecular_function "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] EOG8XH2GQ GO:0005576 1/2997 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XH2GQ GO:0005509 1/2997 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XH2GQ GO:0007601 1/2997 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8XH2GQ GO:0003824 1/2997 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8XH2GQ GO:0005811 1/2997 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8DBWTW GO:0016021 122/391 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWTW GO:0022857 118/391 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8DBWTW GO:0055085 3/391 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8DBWTW GO:0005215 2/391 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8DBWTW GO:0007390 1/391 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8DBWTW GO:0008643 1/391 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8DBWTW GO:0015695 1/391 organic cation transport biological_process "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] EOG8DBWTW GO:0030307 1/391 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8DBWTW GO:0015101 1/391 organic cation transmembrane transporter activity molecular_function "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8DBWTW GO:0040018 1/391 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8DBWTW GO:0006915 1/391 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8DBWTW GO:0006811 1/391 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8DBWTW GO:0032440 1/391 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8TXF7F GO:0046872 9/77 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG854CCD GO:0006511 26/111 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG854CCD GO:0031461 25/111 cullin-RING ubiquitin ligase complex cellular_component "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] EOG854CCD GO:0001745 1/111 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG854CCD GO:0007291 1/111 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG854CCD GO:0007409 1/111 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG854CCD GO:0007476 1/111 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG854CCD GO:0006919 1/111 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG854CCD GO:0005737 1/111 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG854CCD GO:0007283 1/111 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG854CCD GO:0007423 1/111 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG854CCD GO:0004842 1/111 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG854CCD GO:0030431 1/111 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG854CCD GO:0030162 1/111 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG854CCD GO:0031463 1/111 Cul3-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] EOG854CCD GO:0016567 1/111 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG854CCD GO:0045475 1/111 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG854CCD GO:0045187 1/111 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG854CCD GO:0048813 1/111 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8WQ3K5 GO:0008137 2/82 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8WQ3K5 GO:0003954 1/82 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG822D17 GO:0016021 2/37 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GQSJW GO:0005615 39/119 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8GQSJW GO:0008233 5/119 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8GQSJW GO:0016740 5/119 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8GQSJW GO:0048149 1/119 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8GQSJW GO:0035011 1/119 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8GQSJW GO:0009611 1/119 response to wounding biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] EOG8GQSJW GO:0008063 1/119 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8GQSJW GO:0005576 1/119 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GQSJW GO:0010951 1/119 negative regulation of endopeptidase activity biological_process "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] EOG8GQSJW GO:0004857 1/119 enzyme inhibitor activity molecular_function "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai] EOG8GQSJW GO:0002213 1/119 defense response to insect biological_process "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] EOG8GQSJW GO:0000155 1/119 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8GQSJW GO:0009950 1/119 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8GQSJW GO:0045861 1/119 negative regulation of proteolysis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] EOG8GQSJW GO:0035006 1/119 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8GQSJW GO:0035009 1/119 negative regulation of melanization defense response biological_process "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] EOG8GQSJW GO:0004867 1/119 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8GQSJW GO:0016020 1/119 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GQSJW GO:0050832 1/119 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8CVJP4 GO:0043565 47/146 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CVJP4 GO:0005634 47/146 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CVJP4 GO:0003700 45/146 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CVJP4 GO:0006366 2/146 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8CVJP4 GO:0006357 2/146 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8CVJP4 GO:0000981 2/146 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8CVJP4 GO:0030154 1/146 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8CVJP4 GO:0006355 1/146 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CVJP4 GO:0005840 1/146 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8CVJP4 GO:0042742 1/146 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8CVJP4 GO:0048813 1/146 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8CVJP7 GO:0005801 27/77 cis-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] EOG8CVJP7 GO:0006888 27/77 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG8CVJP7 GO:0016192 1/77 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8CVJP7 GO:0030008 1/77 TRAPP complex cellular_component "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257] EOG8CVJP6 GO:0016758 34/154 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG82FVZW GO:0008903 26/87 hydroxypyruvate isomerase activity molecular_function "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11955] EOG82FVZW GO:0046487 1/87 glyoxylate metabolic process biological_process "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] EOG82FVZW GO:0005576 1/87 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG82FVZQ GO:0007275 1/12 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG82FVZQ GO:0016055 1/12 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8D297B GO:0005524 2/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82FVZ7 GO:0003755 26/72 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG82FVZ7 GO:0006457 26/72 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG82FVZ7 GO:0017176 2/72 phosphatidylinositol N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] EOG82FVZ7 GO:0016021 2/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82FVZ7 GO:0006506 2/72 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG82FVZ7 GO:0071011 1/72 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG82FVZ7 GO:0016853 1/72 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG82FVZ7 GO:0071013 1/72 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG82FVZ7 GO:0000398 1/72 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CVJPB GO:0005549 1/14 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8FR36G GO:0016021 86/188 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FR36G GO:0055085 85/188 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8FR36G GO:0005215 29/188 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FR36G GO:0031427 1/188 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FR36G GO:0052591 1/188 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity molecular_function "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN] EOG8FR36G GO:0006072 1/188 glycerol-3-phosphate metabolic process biological_process "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] EOG8FR36G GO:0022857 1/188 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8FR36G GO:0009331 1/188 glycerol-3-phosphate dehydrogenase complex cellular_component "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] EOG812PP6 GO:0008270 1/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG812PP6 GO:0003677 1/12 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Q2GWK GO:0016021 1/120 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84QWGB GO:0004252 1/10 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8Q2GWH GO:0003676 13/42 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q2GWH GO:0046872 1/42 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84QWGK GO:0042302 90/953 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG84QWGK GO:0032784 4/953 regulation of DNA-templated transcription, elongation biological_process "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG84QWGK GO:0031012 4/953 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG84QWGK GO:0006357 4/953 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG84QWGK GO:0008010 3/953 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG84QWGK GO:0040003 3/953 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG84QWGK GO:0005576 2/953 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG84QWGK GO:0003677 2/953 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84QWGK GO:0008061 2/953 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG84QWGK GO:0006334 1/953 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG84QWGK GO:0022008 1/953 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84QWGK GO:0003676 1/953 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84QWGK GO:0030023 1/953 extracellular matrix constituent conferring elasticity molecular_function "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] EOG84QWGK GO:0005737 1/953 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84QWGK GO:0000786 1/953 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG84QWGK GO:0016874 1/953 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG84QWGK GO:0018149 1/953 peptide cross-linking biological_process "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] EOG84QWGK GO:0005201 1/953 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG84QWGK GO:0005634 1/953 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84QWGK GO:0006030 1/953 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG84QWGK GO:0032992 1/953 protein-carbohydrate complex cellular_component "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other." [GOC:mah] EOG8QFZV3 GO:0005975 201/525 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8QFZV3 GO:0043169 199/525 cation binding molecular_function "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] EOG8QFZV3 GO:0003824 188/525 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QFZV3 GO:0032450 12/525 maltose alpha-glucosidase activity molecular_function "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] EOG8QFZV3 GO:0016740 1/525 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8QFZV3 GO:0003677 1/525 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CG2Q6 GO:0016757 25/179 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8CG2Q6 GO:0006810 4/179 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8CG2Q6 GO:0016021 4/179 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CG2Q6 GO:0004578 2/179 chitobiosyldiphosphodolichol beta-mannosyltransferase activity molecular_function "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] EOG8CG2Q6 GO:0018024 1/179 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8H1D9Z GO:0016021 1/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H1D9B GO:0005524 85/230 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H1D9B GO:0004674 78/230 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8H1D9B GO:0004691 9/230 cAMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] EOG8H1D9B GO:0006468 4/230 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8H1D9B GO:0005952 3/230 cAMP-dependent protein kinase complex cellular_component "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] EOG8H1D9B GO:0007476 2/230 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8H1D9B GO:0005515 2/230 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8H1D9B GO:0007480 1/230 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8H1D9B GO:0007611 1/230 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8H1D9B GO:0007314 1/230 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8H1D9B GO:0050804 1/230 modulation of synaptic transmission biological_process "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] EOG8H1D9B GO:0022008 1/230 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8H1D9B GO:0045187 1/230 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG8H1D9B GO:0007615 1/230 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG8H1D9B GO:0042981 1/230 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8H1D9B GO:0048749 1/230 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8H1D9B GO:0005886 1/230 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8H1D9B GO:0007612 1/230 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG8H1D9B GO:0007622 1/230 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG8H1D9B GO:0007448 1/230 anterior/posterior pattern specification, imaginal disc biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] EOG8H1D9B GO:0040040 1/230 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8H1D9B GO:0004672 1/230 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8H1D9B GO:0019933 1/230 cAMP-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG8H1D9B GO:0048149 1/230 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8H1D9B GO:0007613 1/230 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG8H1D9B GO:0007228 1/230 positive regulation of hh target transcription factor activity biological_process "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] EOG8H1D9B GO:0008103 1/230 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG8H1D9B GO:0045879 1/230 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8H1D9B GO:0008355 1/230 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8H1D9B GO:0007317 1/230 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8H1D9B GO:0045475 1/230 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8H1D9B GO:0048477 1/230 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8H1D9B GO:0008359 1/230 regulation of bicoid mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] EOG8NKF98 GO:0016021 134/389 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF98 GO:0007602 130/389 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8NKF98 GO:0007601 128/389 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8NKF98 GO:0004930 128/389 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NKF98 GO:0018298 122/389 protein-chromophore linkage biological_process "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] EOG8NKF98 GO:0009881 116/389 photoreceptor activity molecular_function "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] EOG8NKF98 GO:0009584 6/389 detection of visible light biological_process "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0008020 6/389 G-protein coupled photoreceptor activity molecular_function "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] EOG8NKF98 GO:0007186 6/389 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8NKF98 GO:0009589 3/389 detection of UV biological_process "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] EOG8NKF98 GO:0016028 3/389 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8NKF98 GO:0007604 2/389 phototransduction, UV biological_process "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0043153 2/389 entrainment of circadian clock by photoperiod biological_process "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] EOG8NKF98 GO:0007605 2/389 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8NKF98 GO:0005767 1/389 secondary lysosome cellular_component "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] EOG8NKF98 GO:0009642 1/389 response to light intensity biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] EOG8NKF98 GO:0008344 1/389 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8NKF98 GO:0042052 1/389 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8NKF98 GO:0043052 1/389 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8NKF98 GO:0008594 1/389 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8NKF98 GO:0016027 1/389 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG8NKF98 GO:0009416 1/389 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8NKF98 GO:0030265 1/389 phospholipase C-activating rhodopsin mediated signaling pathway biological_process "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931] EOG8NKF98 GO:0046673 1/389 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8NKF98 GO:0042331 1/389 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8NKF98 GO:0016038 1/389 absorption of visible light biological_process "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0005771 1/389 multivesicular body cellular_component "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] EOG8NKF98 GO:0016039 1/389 absorption of UV light biological_process "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0005791 1/389 rough endoplasmic reticulum cellular_component "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] EOG8NKF98 GO:0016023 1/389 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG8NKF98 GO:0009588 1/389 UV-A, blue light phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah] EOG8NKF98 GO:0016029 1/389 subrhabdomeral cisterna cellular_component "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] EOG8NKF98 GO:0005515 1/389 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NKF98 GO:0000122 1/389 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NKF98 GO:0071632 1/389 optomotor response biological_process "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] EOG8NKF98 GO:0005886 1/389 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG82C0R5 GO:0008080 11/60 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8FFGG3 GO:0007165 110/271 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8FFGG3 GO:0016021 58/271 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGG3 GO:0000281 2/271 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8FFGG3 GO:0045087 2/271 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8FFGG3 GO:0006967 2/271 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8FFGG3 GO:0008063 2/271 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8FFGG3 GO:0004721 2/271 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8FFGG3 GO:0009620 1/271 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG8FFGG3 GO:0009880 1/271 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8FFGG3 GO:0007352 1/271 zygotic specification of dorsal/ventral axis biological_process "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] EOG8FFGG3 GO:0005737 1/271 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FFGG3 GO:0016201 1/271 synaptic target inhibition biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] EOG8FFGG3 GO:0019732 1/271 antifungal humoral response biological_process "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8FFGG3 GO:0019730 1/271 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8FFGG3 GO:0015026 1/271 coreceptor activity molecular_function "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] EOG8FFGG3 GO:0019901 1/271 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG8FFGG3 GO:0003676 1/271 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FFGG3 GO:0051536 1/271 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8FFGG3 GO:0050832 1/271 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8FFGG3 GO:0004888 1/271 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8FFGG3 GO:0043234 1/271 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8FFGG3 GO:0045610 1/271 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8FFGG3 GO:0070976 1/271 TIR domain binding molecular_function "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] EOG8FFGG3 GO:0009950 1/271 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FFGG3 GO:0007416 1/271 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8FFGG3 GO:0035172 1/271 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8FFGG3 GO:0019955 1/271 cytokine binding molecular_function "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] EOG8FFGG3 GO:0007155 1/271 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8FFGG3 GO:0007507 1/271 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8FFGG3 GO:0005769 1/271 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8FFGG3 GO:0006963 1/271 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG8FFGG3 GO:0005515 1/271 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FFGG3 GO:0002807 1/271 positive regulation of antimicrobial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] EOG8FFGG3 GO:0009897 1/271 external side of plasma membrane cellular_component "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] EOG8FFGG3 GO:0042802 1/271 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8FFGG3 GO:0005121 1/271 Toll binding molecular_function "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] EOG8FFGG3 GO:0050830 1/271 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8FFGG3 GO:0006952 1/271 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8FFGG3 GO:0030097 1/271 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8FFGG3 GO:0005886 1/271 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FFGG3 GO:0009617 1/271 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8FFGG3 GO:0008270 1/271 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FFGG3 GO:0002121 1/271 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8FFGG3 GO:0006955 1/271 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8HB122 GO:0008173 28/72 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG8HB122 GO:0008171 28/72 O-methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] EOG8HB122 GO:0003723 1/72 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HB122 GO:0046872 1/72 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HB122 GO:0034587 1/72 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG8HB122 GO:0030422 1/72 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG8HB122 GO:0035194 1/72 posttranscriptional gene silencing by RNA biological_process "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283] EOG8HB122 GO:0001510 1/72 RNA methylation biological_process "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] EOG8NKF95 GO:0016772 8/57 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8K6JJD GO:0005524 26/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K6JJD GO:0004674 23/82 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8K6JJD GO:0004697 2/82 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8K6JJD GO:0007292 1/82 female gamete generation biological_process "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] EOG8K6JJD GO:0030307 1/82 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8K6JJD GO:0046620 1/82 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8K6JJD GO:0006468 1/82 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8K6JJD GO:0031594 1/82 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8K6JJD GO:0030154 1/82 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8K6JJD GO:0006915 1/82 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8K6JJD GO:0007166 1/82 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8K6JJD GO:0005886 1/82 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8K6JJD GO:0043066 1/82 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8K6JJD GO:0008286 1/82 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG8K6JJD GO:0005737 1/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K6JJD GO:0004672 1/82 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8K6JJD GO:0005829 1/82 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8K6JJD GO:0051124 1/82 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8K6JJD GO:0007283 1/82 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8K6JJD GO:0001558 1/82 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8K6JJD GO:0045793 1/82 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8K6JJD GO:0007476 1/82 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8K6JJD GO:0007548 1/82 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG8K6JJD GO:0006974 1/82 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8K6JJK GO:0008168 24/87 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8K6JJK GO:0003676 21/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K6JJK GO:0006370 1/87 7-methylguanosine mRNA capping biological_process "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] EOG8K6JJK GO:0004483 1/87 mRNA (nucleoside-2'-O-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] EOG8K6JJK GO:0005524 1/87 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K6JJK GO:0097309 1/87 cap1 mRNA methylation biological_process "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356] EOG8K6JJK GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K6JJK GO:0080009 1/87 mRNA methylation biological_process "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] EOG8K6JJM GO:0022891 1/8 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8K6JJM GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGT GO:0016021 11/155 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGT GO:0000139 6/155 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8FFGGT GO:0005351 6/155 sugar:proton symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] EOG8FFGGT GO:0006810 4/155 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8FFGGT GO:0016020 1/155 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FFGGT GO:0004222 1/155 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8FFGGV GO:0005739 1/77 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8FFGGV GO:0006390 1/77 transcription from mitochondrial promoter biological_process "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] EOG8HB12K GO:0003676 5/387 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HB12K GO:0003723 1/387 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HB12K GO:0003964 1/387 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8HB12K GO:0004842 1/387 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8W10T8 GO:0016021 27/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGC GO:0005509 16/78 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8QFZVW GO:0045892 1/39 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8QFZVW GO:0005634 1/39 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QFZVW GO:0008039 1/39 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8TB6R9 GO:0003676 2/22 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TB6R9 GO:0046872 2/22 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TB6R9 GO:0003677 1/22 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TB6R9 GO:0005634 1/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TB6R9 GO:0008270 1/22 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRF7 GO:0008061 1/13 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8PVRF7 GO:0005576 1/13 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PVRF7 GO:0006030 1/13 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG866Z15 GO:0005615 76/159 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG866Z15 GO:0019239 72/159 deaminase activity molecular_function "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] EOG866Z15 GO:0008283 5/159 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG866Z15 GO:0008083 5/159 growth factor activity molecular_function "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] EOG866Z15 GO:0004000 5/159 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG866Z15 GO:0046103 5/159 inosine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] EOG866Z15 GO:0006154 5/159 adenosine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] EOG866Z15 GO:0043103 5/159 hypoxanthine salvage biological_process "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732] EOG866Z15 GO:0016021 1/159 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z15 GO:0042386 1/159 hemocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] EOG866Z15 GO:0016020 1/159 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG866Z15 GO:0006109 1/159 regulation of carbohydrate metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] EOG866Z15 GO:0043617 1/159 cellular response to sucrose starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl] EOG866Z15 GO:0007286 1/159 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8WSZTV GO:0022008 1/75 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WSZTV GO:0005515 1/75 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WSZTS GO:0006334 5/11 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8WSZTS GO:0005634 5/11 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WSZTS GO:0003677 5/11 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8WSZTS GO:0000786 5/11 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8STVJH GO:0016021 8/57 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8STVJH GO:0016491 8/57 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8STVJH GO:0005506 8/57 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8STVJH GO:0006633 8/57 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG876NFQ GO:0046331 1/84 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8HQGZP GO:0016021 64/135 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HQGZP GO:0022891 61/135 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8HQGZP GO:0008643 4/135 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8HQGZP GO:0022857 3/135 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG85TG3G GO:0051213 1/94 dioxygenase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] EOG85TG3G GO:0048244 1/94 phytanoyl-CoA dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068] EOG8MWBKV GO:0004725 22/93 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8MWBKV GO:0007155 1/93 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8MWBKV GO:0008045 1/93 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8MWBKV GO:0007411 1/93 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8MWBKV GO:0007414 1/93 axonal defasciculation biological_process "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] EOG8MWBKV GO:0046331 1/93 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8MWBKV GO:0006470 1/93 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8MWBKV GO:0007409 1/93 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8MWBKV GO:0005001 1/93 transmembrane receptor protein tyrosine phosphatase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8MWBKV GO:0048813 1/93 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8MWBKV GO:0007415 1/93 defasciculation of motor neuron axon biological_process "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] EOG8MWBKV GO:0016021 1/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MWBKV GO:0035335 1/93 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8MWBKV GO:0050254 1/93 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8MWBKV GO:0030424 1/93 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8MWBKV GO:0005886 1/93 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8ZGRS8 GO:0003676 1/32 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZGRS8 GO:0008270 1/32 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZGRS8 GO:0005634 1/32 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MSGDQ GO:0003676 3/26 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MSGDQ GO:0046872 3/26 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KSS1F GO:0000166 21/83 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8KSS1F GO:0003676 16/83 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KSS1F GO:0003746 3/83 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8KSS1F GO:0017053 2/83 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG8KSS1F GO:0007070 2/83 negative regulation of transcription from RNA polymerase II promoter during mitosis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] EOG8KSS1F GO:0005634 2/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8KSS1F GO:0003723 2/83 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8KSS1F GO:0005694 2/83 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8KSS1F GO:0006351 1/83 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8KSS1F GO:0006368 1/83 transcription elongation from RNA polymerase II promoter biological_process "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] EOG8KSS1F GO:0008023 1/83 transcription elongation factor complex cellular_component "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] EOG8KSS1F GO:0032021 1/83 NELF complex cellular_component "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] EOG8KSS1F GO:0003729 1/83 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8KSS1F GO:0022008 1/83 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KSS1F GO:0034244 1/83 negative regulation of transcription elongation from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] EOG8KSS1F GO:0045944 1/83 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8KSS1F GO:0005515 1/83 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KSS1F GO:0000122 1/83 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8KSS1F GO:0032785 1/83 negative regulation of DNA-templated transcription, elongation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8KSS12 GO:0004252 2/12 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8ZGRSF GO:0004402 1/113 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8ZGRSF GO:0042384 1/113 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8ZGRSF GO:0005509 1/113 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8ZGRSF GO:0031513 1/113 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8ZGRSF GO:0035058 1/113 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG87Q0N4 GO:0005525 24/80 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG87Q0N4 GO:0015031 24/80 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG87Q0N4 GO:0007264 23/80 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG87Q0N4 GO:0034334 1/80 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG87Q0N4 GO:0030866 1/80 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG87Q0N4 GO:0032794 1/80 GTPase activating protein binding molecular_function "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] EOG87Q0N4 GO:0031410 1/80 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG87Q0N4 GO:0007317 1/80 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG87Q0N4 GO:0007349 1/80 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG87Q0N4 GO:0048210 1/80 Golgi vesicle fusion to target membrane biological_process "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG87Q0N4 GO:0046664 1/80 dorsal closure, amnioserosa morphology change biological_process "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] EOG87Q0N4 GO:0055037 1/80 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG87Q0N4 GO:0008103 1/80 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG87Q0N4 GO:0003924 1/80 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG87Q0N4 GO:0022416 1/80 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG87Q0N4 GO:0032482 1/80 Rab protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] EOG87Q0N4 GO:0070732 1/80 spindle envelope cellular_component "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] EOG87Q0N4 GO:0007112 1/80 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG87Q0N4 GO:0045202 1/80 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG87Q0N4 GO:0031982 1/80 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG87Q0N4 GO:0005635 1/80 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG87Q0N4 GO:0045169 1/80 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG87Q0N4 GO:0032154 1/80 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG87Q0N4 GO:0048477 1/80 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG87Q0N4 GO:0042998 1/80 positive regulation of Golgi to plasma membrane protein transport biological_process "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] EOG87Q0N4 GO:0050807 1/80 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG87Q0N4 GO:0005737 1/80 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87Q0N4 GO:0005768 1/80 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG87Q0N4 GO:0048471 1/80 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG87Q0N4 GO:0005811 1/80 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG87Q0N4 GO:0042052 1/80 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG87Q0N4 GO:0007298 1/80 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG87Q0N4 GO:0030718 1/80 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG87Q0N4 GO:0007391 1/80 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG87Q0N4 GO:0032403 1/80 protein complex binding molecular_function "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] EOG87Q0N4 GO:0048599 1/80 oocyte development biological_process "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] EOG87Q0N4 GO:2000039 1/80 regulation of trichome morphogenesis biological_process "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol] EOG87Q0N4 GO:0001745 1/80 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG87Q0N4 GO:0042078 1/80 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG87Q0N4 GO:0019730 1/80 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG87Q0N4 GO:0045886 1/80 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG87Q0N4 GO:0006897 1/80 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG87Q0N4 GO:0051642 1/80 centrosome localization biological_process "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG87Q0N4 GO:0060187 1/80 cell pole cellular_component "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] EOG87Q0N4 GO:0005515 1/80 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87Q0N4 GO:0007394 1/80 dorsal closure, elongation of leading edge cells biological_process "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] EOG87Q0N4 GO:0006184 1/80 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG87Q0N4 GO:0043025 1/80 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG87Q0N4 GO:0048749 1/80 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG87Q0N4 GO:0005794 1/80 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG87Q0N4 GO:0030723 1/80 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG87Q0N4 GO:0045478 1/80 fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] EOG87Q0N4 GO:0030140 1/80 trans-Golgi network transport vesicle cellular_component "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] EOG87Q0N4 GO:0048137 1/80 spermatocyte division biological_process "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] EOG87Q0N4 GO:0043195 1/80 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG87Q0N4 GO:0000916 1/80 actomyosin contractile ring contraction biological_process "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] EOG87Q0N4 GO:0031532 1/80 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG87Q0N4 GO:0005776 1/80 autophagosome cellular_component "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] EOG87Q0N4 GO:0016360 1/80 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG89GNXB GO:0008532 4/91 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] EOG89GNXB GO:0016740 1/91 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG89GNXB GO:0016757 1/91 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8X3KGV GO:0005509 8/38 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8X3KGV GO:0007229 1/38 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG89GNXD GO:0004500 2/176 dopamine beta-monooxygenase activity molecular_function "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120] EOG89GNXD GO:0008293 1/176 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG89GNXD GO:0008362 1/176 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG89GNXD GO:0001838 1/176 embryonic epithelial tube formation biological_process "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] EOG89GNXD GO:0035158 1/176 regulation of tube diameter, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] EOG89GNXD GO:0042626 1/176 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG89GNXD GO:0035151 1/176 regulation of tube size, open tracheal system biological_process "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] EOG89GNXD GO:0016021 1/176 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89GNXD GO:0035152 1/176 regulation of tube architecture, open tracheal system biological_process "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] EOG89GNXD GO:0006031 1/176 chitin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG89GNXD GO:0005524 1/176 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89GNXD GO:0060439 1/176 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG89GNXD GO:0007424 1/176 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG89GNXD GO:0007362 1/176 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG89GNXD GO:0006035 1/176 cuticle chitin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] EOG8NCPTB GO:0016746 24/265 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8NCPTB GO:0000502 4/265 proteasome complex cellular_component "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] EOG8NCPTB GO:0016021 2/265 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NCPTB GO:0005838 1/265 proteasome regulatory particle cellular_component "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] EOG8NCPTB GO:0006508 1/265 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8NCPTB GO:0008541 1/265 proteasome regulatory particle, lid subcomplex cellular_component "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] EOG8NCPTB GO:0003735 1/265 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8NCPTB GO:0005875 1/265 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NCPTB GO:0006412 1/265 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8NCPTB GO:0005840 1/265 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8NCPTB GO:0043161 1/265 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG8DRCTF GO:0050353 18/85 trimethyllysine dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14184] EOG8DRCTF GO:0045329 18/85 carnitine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] EOG8DRCTF GO:0031418 18/85 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8DRCTF GO:0005506 18/85 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8DRCTF GO:0003676 6/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DRCTF GO:0016491 2/85 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8DRCTF GO:0051213 2/85 dioxygenase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] EOG8DRCTF GO:0008336 1/85 gamma-butyrobetaine dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031] EOG870X03 GO:0005783 25/90 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG870X03 GO:0016021 25/90 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG870X03 GO:0005811 1/90 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG870X03 GO:0006621 1/90 protein retention in ER lumen biological_process "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] EOG870X03 GO:0005786 1/90 signal recognition particle, endoplasmic reticulum targeting cellular_component "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] EOG870X03 GO:0005048 1/90 signal sequence binding molecular_function "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] EOG8DRCTS GO:0005853 48/165 eukaryotic translation elongation factor 1 complex cellular_component "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] EOG8DRCTS GO:0003746 48/165 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8DRCTS GO:0006414 2/165 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8DRCTS GO:0005875 1/165 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DRCTS GO:0005829 1/165 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8DRCTS GO:0005811 1/165 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8J13Q1 GO:0004252 4/19 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8QZB2Z GO:0005739 3/87 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8QZB2Z GO:0032543 2/87 mitochondrial translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] EOG8QZB2Z GO:0070681 2/87 glutaminyl-tRNAGln biosynthesis via transamidation biological_process "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] EOG8QZB2Z GO:0030956 2/87 glutamyl-tRNA(Gln) amidotransferase complex cellular_component "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] EOG8QZB2Z GO:0006450 2/87 regulation of translational fidelity biological_process "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] EOG8QZB2Z GO:0003887 2/87 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8QZB2Z GO:0050567 2/87 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG8QZB2Z GO:0005524 2/87 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QZB2Z GO:0006264 1/87 mitochondrial DNA replication biological_process "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] EOG8QZB2Z GO:0005515 1/87 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QZB2Z GO:0000002 1/87 mitochondrial genome maintenance biological_process "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] EOG8QZB2Z GO:0005760 1/87 gamma DNA polymerase complex cellular_component "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] EOG8QZB2Z GO:0006261 1/87 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG8QZB2Z GO:0004812 1/87 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8QZB2Z GO:0007005 1/87 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8BS026 GO:0007156 1/35 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8BS026 GO:0005509 1/35 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8BS026 GO:0005886 1/35 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TMTJN GO:0016020 3/21 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TMTJN GO:0016757 3/21 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8PP0WT GO:0006886 29/133 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8PP0WT GO:0008565 28/133 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8PP0WT GO:0016192 28/133 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8PP0WT GO:0005794 27/133 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8PP0WT GO:0030131 27/133 clathrin adaptor complex cellular_component "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] EOG8PP0WT GO:0008021 1/133 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8PP0WT GO:0007269 1/133 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8PP0WT GO:0030136 1/133 clathrin-coated vesicle cellular_component "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] EOG8PP0WT GO:0005802 1/133 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG8PP0WT GO:0030117 1/133 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG8PP0WT GO:0033363 1/133 secretory granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] EOG8PP0WT GO:0006901 1/133 vesicle coating biological_process "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] EOG8PP0WT GO:0035652 1/133 cargo loading into clathrin-coated vesicle biological_process "Formation of a protein complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins that are going to be transported by a vesicle." [PMID:16162817] EOG8PP0WT GO:0030121 1/133 AP-1 adaptor complex cellular_component "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] EOG8PP0WT GO:0030135 1/133 coated vesicle cellular_component "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] EOG8PP0WT GO:0048749 1/133 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8PP0WT GO:0016183 1/133 synaptic vesicle coating biological_process "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709] EOG8PP0WT GO:0055037 1/133 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG8PP0WT GO:0030141 1/133 secretory granule cellular_component "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] EOG8XD660 GO:0016787 32/178 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XD660 GO:0006044 28/178 N-acetylglucosamine metabolic process biological_process "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] EOG8XD660 GO:0004342 28/178 glucosamine-6-phosphate deaminase activity molecular_function "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175] EOG8XD660 GO:0005975 27/178 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8XD660 GO:0006043 4/178 glucosamine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] EOG8XD660 GO:0005737 4/178 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XD660 GO:0006091 4/178 generation of precursor metabolites and energy biological_process "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] EOG8XD660 GO:0051301 2/178 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8XD660 GO:0016021 1/178 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD660 GO:0004527 1/178 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8XD660 GO:0046872 1/178 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PRW77 GO:0003796 126/416 lysozyme activity molecular_function "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] EOG8PRW77 GO:0016998 121/416 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8PRW77 GO:0016021 20/416 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PRW77 GO:0005886 10/416 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PRW77 GO:0006811 10/416 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8PRW77 GO:0005230 10/416 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PRW77 GO:0019835 9/416 cytolysis biological_process "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] EOG8PRW77 GO:0042742 8/416 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8PRW77 GO:0030054 8/416 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8PRW77 GO:0045202 8/416 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PRW77 GO:0048102 1/416 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8PRW77 GO:0035071 1/416 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8PRW77 GO:0050829 1/416 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8PRW77 GO:0032504 1/416 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8PRW77 GO:0004568 1/416 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8PRW77 GO:0005615 1/416 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8PRW77 GO:0045824 1/416 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8XD665 GO:0000079 26/90 regulation of cyclin-dependent protein serine/threonine kinase activity biological_process "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] EOG8XD665 GO:0006355 26/90 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG87H863 GO:0042302 5/29 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG87H860 GO:0005634 21/59 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87H860 GO:0051726 21/59 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG87H860 GO:0006950 20/59 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG87H860 GO:0046662 1/59 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG87H860 GO:0007254 1/59 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8RBSZH GO:0006355 1/87 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RBSZH GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BS02J GO:0003700 1/41 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8BS02J GO:0005634 1/41 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2F4 GO:0016021 22/77 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2F4 GO:0004930 20/77 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8XH2F4 GO:0007186 1/77 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8XH2F4 GO:0008188 1/77 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8XH2F4 GO:0004983 1/77 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8XH2F4 GO:0007218 1/77 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8QZB29 GO:0000062 23/79 fatty-acyl-CoA binding molecular_function "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] EOG8QZB24 GO:0005272 158/406 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8QZB24 GO:0016021 144/406 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QZB24 GO:0016020 15/406 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QZB24 GO:0003964 2/406 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8QZB24 GO:0003723 2/406 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8QZB24 GO:0007638 1/406 mechanosensory behavior biological_process "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] EOG8QZB24 GO:0043022 1/406 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8QZB24 GO:0050975 1/406 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG8QZB24 GO:0050966 1/406 detection of mechanical stimulus involved in sensory perception of pain biological_process "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG8QZB24 GO:0044736 1/406 acid-sensing ion channel activity molecular_function "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl] EOG8QZB24 GO:0030425 1/406 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8QZB24 GO:0048266 1/406 behavioral response to pain biological_process "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] EOG8QZB24 GO:0008345 1/406 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8QZB24 GO:0043025 1/406 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8QZB24 GO:0042256 1/406 mature ribosome assembly biological_process "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] EOG8QZB24 GO:0035725 1/406 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8QZB24 GO:0030424 1/406 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8CVJQV GO:0016020 1/24 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CVJQV GO:0005215 1/24 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG84F8R0 GO:0003774 6/72 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG84F8R0 GO:0016459 6/72 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG84F8R0 GO:0005524 3/72 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84F8R0 GO:0004871 1/72 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG84F8R0 GO:0016021 1/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84F8R0 GO:0004725 1/72 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG86X1Q7 GO:0046872 68/241 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86X1Q7 GO:0003676 66/241 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86X1Q7 GO:0007366 3/241 periodic partitioning by pair rule gene biological_process "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG86X1Q7 GO:0045893 3/241 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0045944 3/241 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0016348 3/241 imaginal disc-derived leg joint morphogenesis biological_process "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG86X1Q7 GO:0000122 3/241 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0005634 3/241 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86X1Q7 GO:0045892 3/241 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0003677 2/241 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86X1Q7 GO:0007350 2/241 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1Q7 GO:0000981 2/241 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG86X1Q7 GO:0006366 2/241 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86X1Q7 GO:0009880 1/241 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG86X1Q7 GO:0006351 1/241 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86X1Q7 GO:0007480 1/241 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG86X1Q7 GO:0007443 1/241 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG86X1Q7 GO:0046331 1/241 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG86X1Q7 GO:0035220 1/241 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG86X1Q7 GO:0048619 1/241 embryonic hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG86X1Q7 GO:0007442 1/241 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG86X1Q7 GO:0006909 1/241 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG86X1Q7 GO:0003700 1/241 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86X1Q7 GO:0048617 1/241 embryonic foregut morphogenesis biological_process "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG86X1Q7 GO:0007362 1/241 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1Q7 GO:0006357 1/241 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0006355 1/241 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG822D0C GO:0008270 56/152 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG822D0C GO:0016491 51/152 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG822D0C GO:0003939 5/152 L-iditol 2-dehydrogenase activity molecular_function "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] EOG8FR37J GO:0016021 8/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FR37J GO:0016020 8/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Q2GVX GO:0006629 59/262 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8Q2GVX GO:0016788 45/262 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8Q2GVX GO:0016298 13/262 lipase activity molecular_function "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] EOG8Q2GVX GO:0004197 2/262 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8Q2GVX GO:0004622 1/262 lysophospholipase activity molecular_function "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] EOG8Q2GVX GO:0006909 1/262 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8VMHZG GO:0005230 6/66 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8VMHZG GO:0016021 6/66 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VMHZC GO:0007264 2/8 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8VMHZC GO:0005525 2/8 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8616HZ GO:0007155 51/345 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8616HZ GO:0005524 32/345 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616HZ GO:0004672 17/345 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8616HZ GO:0004713 14/345 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8616HZ GO:0004714 7/345 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8616HZ GO:0004715 1/345 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8616HZ GO:0007169 1/345 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8616HZ GO:0006468 1/345 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8616HZ GO:0018108 1/345 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8616HZ GO:0016020 1/345 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TXF69 GO:0005975 35/158 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8TXF69 GO:0004553 35/158 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8TXF69 GO:0005576 3/158 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TXF69 GO:0005215 2/158 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8TXF69 GO:0045088 1/158 regulation of innate immune response biological_process "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8TXF69 GO:0006955 1/158 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8TXF69 GO:0045087 1/158 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8TXF69 GO:0002758 1/158 innate immune response-activating signal transduction biological_process "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8TXF69 GO:0008329 1/158 signaling pattern recognition receptor activity molecular_function "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor] EOG8TXF69 GO:0050830 1/158 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8TXF69 GO:0001872 1/158 (1->3)-beta-D-glucan binding molecular_function "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] EOG8TXF69 GO:0005515 1/158 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TXF69 GO:0030247 1/158 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG8TXF69 GO:0009253 1/158 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8TXF69 GO:0046658 1/158 anchored component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8TXF69 GO:0001530 1/158 lipopolysaccharide binding molecular_function "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] EOG8TXF69 GO:0002221 1/158 pattern recognition receptor signaling pathway biological_process "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] EOG8TXF69 GO:0042834 1/158 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG8FBM6X GO:0003676 2/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FBM6X GO:0005634 1/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FBM6X GO:0008270 1/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FBM6X GO:0046872 1/10 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FBM6Z GO:0048489 1/53 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8FBM6Z GO:0007269 1/53 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8FBM6Z GO:0009612 1/53 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG8FBM6Z GO:0030139 1/53 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG8FBM6Z GO:0007629 1/53 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8FBM6Z GO:0048488 1/53 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8FBM6Z GO:0008021 1/53 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8FBM6Z GO:0016079 1/53 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8FBM6Z GO:0030054 1/53 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8FBM6Z GO:0005515 1/53 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8284HJ GO:0016021 2/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284HJ GO:0008146 2/16 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8JQ6CM GO:0008289 2/67 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8C2KT9 GO:0030242 1/15 pexophagy biological_process "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] EOG8C2KT9 GO:0006914 1/15 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8C2KT9 GO:0032258 1/15 CVT pathway biological_process "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] EOG84F8RX GO:0035220 1/77 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG84F8RX GO:0048749 1/77 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG84F8RX GO:0006909 1/77 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84F8RX GO:0045742 1/77 positive regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG84F8RX GO:0090303 1/77 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG84F8RX GO:0042060 1/77 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG84F8RX GO:0005634 1/77 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84F8RX GO:0022416 1/77 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG86X1QB GO:0042438 3/94 melanin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] EOG86X1QB GO:0005576 3/94 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG86X1QB GO:0048067 3/94 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG86X1QB GO:0004167 3/94 dopachrome isomerase activity molecular_function "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044] EOG86X1QB GO:0042435 2/94 indole-containing compound biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl] EOG86X1QB GO:0006583 2/94 melanin biosynthetic process from tyrosine biological_process "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] EOG86X1QB GO:0048066 2/94 developmental pigmentation biological_process "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] EOG8CVJQ1 GO:0003677 1/63 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84F8RN GO:0016021 1/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPD9 GO:0016059 1/103 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG8VDSCS GO:0003707 29/102 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8VDSCS GO:0005634 29/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VDSCS GO:0006351 28/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8VDSCS GO:0003700 28/102 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8VDSCS GO:0008270 20/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VDSCS GO:0043565 19/102 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8VDSCS GO:0003677 7/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VDSCS GO:0007365 1/102 periodic partitioning biological_process "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] EOG8VDSCS GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VDSCS GO:0040034 1/102 regulation of development, heterochronic biological_process "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] EOG8VDSCS GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8VDSCS GO:0007552 1/102 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8VDSCS GO:0035074 1/102 pupation biological_process "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] EOG8VDSCS GO:0042048 1/102 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8VDSCS GO:0035626 1/102 juvenile hormone mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] EOG8VDSCS GO:0048813 1/102 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8VDSCS GO:0002165 1/102 instar larval or pupal development biological_process "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8VDSCS GO:0008134 1/102 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8VDSCS GO:0055088 1/102 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8VDSCS GO:0007480 1/102 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8VDSCS GO:0045944 1/102 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8VDSCS GO:0008219 1/102 cell death biological_process "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis] EOG8VDSCS GO:0000976 1/102 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8VDSCS GO:0009725 1/102 response to hormone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] EOG8VDSCS GO:0004879 1/102 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8VDSCS GO:0006357 1/102 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8VDSCS GO:0046982 1/102 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8VDSCS GO:0016319 1/102 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8VDSCS GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8VDSCS GO:0035075 1/102 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG8VDSCS GO:0001077 1/102 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8VDSCS GO:0035073 1/102 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG8W6RBK GO:0046872 3/18 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RR8Z9 GO:0016021 18/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z0DPX GO:0006952 31/85 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8Z0DPX GO:0042742 3/85 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8Z0DPX GO:0045087 3/85 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8Z0DPX GO:0005576 2/85 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z0DPX GO:0019731 1/85 antibacterial humoral response biological_process "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8Z0DPX GO:0050830 1/85 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8Z0DPX GO:0009617 1/85 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8Z0DPX GO:0005615 1/85 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z0DPX GO:0006959 1/85 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8SJ7TR GO:0030308 1/118 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8SJ7TR GO:0048190 1/118 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8SJ7TR GO:0005634 1/118 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SJ7TR GO:0000122 1/118 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0006351 1/118 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SJ7TR GO:0045892 1/118 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0005515 1/118 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SJ7TR GO:0070491 1/118 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8SJ7TR GO:0007474 1/118 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8SJ7TR GO:0046843 1/118 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8SJ7TR GO:0048592 1/118 eye morphogenesis biological_process "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] EOG8SJ7TR GO:0006355 1/118 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0007362 1/118 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8SJ7TR GO:0043565 1/118 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CG2PV GO:0006355 26/177 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CG2PV GO:0044237 19/177 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8CG2PV GO:0003743 5/177 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8CG2PV GO:0005737 1/177 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CG2PV GO:0071456 1/177 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8CG2PV GO:0005085 1/177 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8CG2PV GO:0005829 1/177 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8CG2PV GO:0000398 1/177 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CG2PV GO:0071013 1/177 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8CG2PV GO:0016853 1/177 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8CG2PV GO:0022008 1/177 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CG2PV GO:0006446 1/177 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8CG2PV GO:0043087 1/177 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8CG2PV GO:0005851 1/177 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG8CG2PV GO:0046523 1/177 S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992] EOG8CG2PV GO:0071011 1/177 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CG2PV GO:0006413 1/177 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8CJXX1 GO:0004842 21/112 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8CJXX1 GO:0016874 1/112 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8CJXX1 GO:0040011 1/112 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8CJXX1 GO:0042787 1/112 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8CJXX1 GO:0005938 1/112 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8CJXX1 GO:0007623 1/112 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8CJXX1 GO:0048935 1/112 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG8CJXX1 GO:0007616 1/112 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8CJXX1 GO:0005737 1/112 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CJXX1 GO:0005634 1/112 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CJXX1 GO:0048813 1/112 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG82NMFM GO:0005249 2/25 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG82NMFM GO:0008076 2/25 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8QFZWB GO:0004674 1/33 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG86HJVB GO:0004252 2/3 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG82NMFK GO:0043565 15/62 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82NMFK GO:0005634 15/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CG2PH GO:0016758 25/94 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8CG2PH GO:0005789 25/94 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8CG2PH GO:0008299 3/94 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8CG2PH GO:0005524 3/94 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CG2PH GO:0004496 3/94 mevalonate kinase activity molecular_function "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068] EOG8CG2PH GO:0005737 3/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CG2PH GO:0040003 1/94 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8CG2PH GO:0006486 1/94 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8CG2PH GO:0016301 1/94 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8CG2PH GO:0016021 1/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XKXN2 GO:0005524 52/210 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XKXN2 GO:0004713 50/210 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8XKXN2 GO:0004714 5/210 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8XKXN2 GO:0006468 3/210 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8XKXN2 GO:0018108 3/210 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8XKXN2 GO:0007435 3/210 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8XKXN2 GO:0007165 2/210 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8XKXN2 GO:0016021 2/210 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XKXN2 GO:0016055 2/210 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8XKXN2 GO:0005886 2/210 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XKXN2 GO:0016204 2/210 determination of muscle attachment site biological_process "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] EOG8XKXN2 GO:0007411 2/210 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8XKXN2 GO:0016203 2/210 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8XKXN2 GO:0016301 1/210 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8XKXN2 GO:0017147 1/210 Wnt-protein binding molecular_function "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] EOG8XKXN2 GO:0008355 1/210 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8XKXN2 GO:0007482 1/210 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8XKXN2 GO:0030424 1/210 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8XKXN2 GO:0016201 1/210 synaptic target inhibition biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] EOG8XKXN2 GO:0008045 1/210 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8XKXN2 GO:0046331 1/210 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XKXN2 GO:0016199 1/210 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8XKXN2 GO:0007611 1/210 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8XKXN2 GO:0007613 1/210 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG8XKXN6 GO:0033961 66/183 cis-stilbene-oxide hydrolase activity molecular_function "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] EOG8XKXN6 GO:0004301 3/183 epoxide hydrolase activity molecular_function "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] EOG8XKXN6 GO:0004602 2/183 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8XKXN6 GO:0006979 2/183 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8XKXN6 GO:0016787 1/183 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XKXN6 GO:0003824 1/183 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8F4VSW GO:0016021 252/803 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F4VSW GO:0006633 246/803 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8F4VSW GO:0016740 246/803 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8F4VSW GO:0009922 7/803 fatty acid elongase activity molecular_function "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] EOG8F4VSW GO:0030497 7/803 fatty acid elongation biological_process "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] EOG8F4VSW GO:0022008 1/803 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8F4VSW GO:0051225 1/803 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8F4VSW GO:0007112 1/803 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8F4VSW GO:0042761 1/803 very long-chain fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators] EOG8F4VSW GO:0007110 1/803 meiosis I cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8F4VSW GO:0000915 1/803 actomyosin contractile ring assembly biological_process "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] EOG8F4VSW GO:0007111 1/803 meiosis II cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8F4VSW GO:0030176 1/803 integral component of endoplasmic reticulum membrane cellular_component "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] EOG8F4VSW GO:0000212 1/803 meiotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] EOG8TXF6F GO:0016021 73/311 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TXF6F GO:0055085 69/311 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8TXF6F GO:0005432 3/311 calcium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] EOG8TXF6F GO:0003824 1/311 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8TXF6F GO:0015293 1/311 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8TXF6F GO:0005886 1/311 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TXF6F GO:0006816 1/311 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8TXF6F GO:0006814 1/311 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8TXF6F GO:0008273 1/311 calcium, potassium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] EOG8TXF6F GO:0035725 1/311 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8F4VSP GO:0008270 5/34 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F4VSP GO:0003700 5/34 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8F4VSP GO:0005634 5/34 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F4VSP GO:0043565 5/34 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8F4VSP GO:0006351 1/34 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG84QWFB GO:0016021 15/70 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84QWFB GO:0022857 13/70 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG84QWFB GO:0055085 2/70 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG84QWFB GO:0005215 2/70 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8X6FPK GO:0005524 38/127 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FPK GO:0004674 37/127 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8X6FPK GO:0050321 3/127 tau-protein kinase activity molecular_function "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] EOG8X6FPK GO:0004672 2/127 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8X6FPK GO:0006468 2/127 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8X6FPK GO:0030054 1/127 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8X6FPK GO:0016301 1/127 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8X6FPK GO:0005634 1/127 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X6FPK GO:0045879 1/127 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8X6FPK GO:0072347 1/127 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG8X6FPK GO:0045475 1/127 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8X6FPK GO:0032436 1/127 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] EOG8X6FPK GO:0016055 1/127 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8X6FPK GO:0008355 1/127 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8X6FPK GO:0048477 1/127 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8X6FPK GO:0030178 1/127 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8X6FPK GO:0045169 1/127 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8X6FPK GO:0035293 1/127 chitin-based larval cuticle pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8X6FPK GO:0045610 1/127 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8X6FPK GO:0005813 1/127 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8X6FPK GO:0031594 1/127 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8X6FPK GO:0090163 1/127 establishment of epithelial cell planar polarity biological_process "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8X6FPK GO:0007219 1/127 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8X6FPK GO:0072686 1/127 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8X6FPK GO:0005737 1/127 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X6FPK GO:0045886 1/127 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8X6FPK GO:0007623 1/127 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8X6FPK GO:0007367 1/127 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8X6FPK GO:0008407 1/127 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8X6FPK GO:0042306 1/127 regulation of protein import into nucleus biological_process "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] EOG8X6FPK GO:0005515 1/127 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8X6FPK GO:0046959 1/127 habituation biological_process "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] EOG8X6FPK GO:0009649 1/127 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG8X6FPK GO:0005938 1/127 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8X6FPK GO:0030162 1/127 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8X6FPK GO:0043508 1/127 negative regulation of JUN kinase activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl] EOG8X6FPK GO:0035309 1/127 wing and notum subfield formation biological_process "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] EOG8X6FPK GO:0030424 1/127 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8X6FPK GO:0007622 1/127 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG8X6FPK GO:0005654 1/127 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8X6FPK GO:0045732 1/127 positive regulation of protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] EOG8X6FPK GO:0007143 1/127 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8X6FPK GO:0042752 1/127 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG8X6FPK GO:0051124 1/127 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8X6FPK GO:0030589 1/127 pseudocleavage involved in syncytial blastoderm formation biological_process "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8X6FPK GO:0003382 1/127 epithelial cell morphogenesis biological_process "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8X6FPK GO:0045842 1/127 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8X6FPK GO:0007423 1/127 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8X6FPK GO:0035324 1/127 female germline ring canal cellular_component "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420] EOG8X6FPK GO:0070507 1/127 regulation of microtubule cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8X6FPK GO:0048232 1/127 male gamete generation biological_process "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] EOG8X6FPK GO:0007507 1/127 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8X6FPK GO:0035019 1/127 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG8X6FPK GO:0030707 1/127 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8X6FPK GO:0070884 1/127 regulation of calcineurin-NFAT signaling cascade biological_process "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] EOG8X6FPK GO:0007051 1/127 spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] EOG8F4VSG GO:0016491 199/611 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F4VSG GO:0047886 2/611 farnesol dehydrogenase activity molecular_function "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700] EOG8F4VSG GO:0004316 1/611 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8F4VSG GO:0016063 1/611 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8F4VSG GO:0022008 1/611 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8R52GV GO:0006464 26/89 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8R52GV GO:0005524 2/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R52GV GO:0004835 1/89 tubulin-tyrosine ligase activity molecular_function "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] EOG8R52GW GO:0016021 27/113 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R52GW GO:0055085 27/113 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8TXF6Z GO:0006030 11/39 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8TXF6Z GO:0005576 11/39 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TXF6Z GO:0008061 11/39 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XKXNR GO:0005524 1/71 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XKXNR GO:0032039 1/71 integrator complex cellular_component "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] EOG8XKXNR GO:0005634 1/71 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XKXNR GO:0034472 1/71 snRNA 3'-end processing biological_process "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] EOG8XKXNR GO:0017111 1/71 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8M680D GO:0016706 1/59 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG8F20HJ GO:0005506 142/475 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8F20HJ GO:0020037 142/475 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8F20HJ GO:0016705 139/475 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8F20HJ GO:0004497 138/475 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8F20HJ GO:0005789 5/475 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8F20HJ GO:0070330 1/475 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8F20HJ GO:0033777 1/475 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG8F20HJ GO:0050591 1/475 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG8F20HJ GO:0033780 1/475 taurochenodeoxycholate 6alpha-hydroxylase activity molecular_function "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] EOG8F20HJ GO:0035220 1/475 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8CRPDW GO:0003867 29/99 4-aminobutyrate transaminase activity molecular_function "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] EOG8CRPDW GO:0009448 29/99 gamma-aminobutyric acid metabolic process biological_process "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] EOG8CRPDW GO:0030170 29/99 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8T4G96 GO:0006012 27/98 galactose metabolic process biological_process "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] EOG8T4G96 GO:0004335 27/98 galactokinase activity molecular_function "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556] EOG8T4G96 GO:0005524 27/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T4G96 GO:0005737 27/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4G96 GO:0033858 2/98 N-acetylgalactosamine kinase activity molecular_function "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] EOG8T4G94 GO:0004568 2/15 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8T4G94 GO:0005975 2/15 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8T4G94 GO:0006032 2/15 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8T4G98 GO:0046872 7/51 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8T4G98 GO:0006886 6/51 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8W6RB3 GO:0044237 22/91 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8W6RB3 GO:0003743 7/91 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8W6RB3 GO:0006413 1/91 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8W6RB3 GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8W6RB3 GO:0005851 1/91 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG8W6RB3 GO:0030234 1/91 enzyme regulator activity molecular_function "Binds to and modulates the activity of an enzyme." [GOC:mah] EOG8W6RB3 GO:0006446 1/91 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8W6RB3 GO:0043087 1/91 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8W6RB3 GO:0005829 1/91 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8W6RB3 GO:0050790 1/91 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8W6RB3 GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W6RB3 GO:0005085 1/91 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8VHNMS GO:0008299 25/81 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8VHNMS GO:0004163 25/81 diphosphomevalonate decarboxylase activity molecular_function "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735] EOG8VHNMS GO:0005524 23/81 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VHNMV GO:0019205 5/29 nucleobase-containing compound kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] EOG8VHNMV GO:0005524 5/29 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VHNMV GO:0006139 5/29 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG8VHNMV GO:0004017 1/29 adenylate kinase activity molecular_function "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] EOG8X3KFV GO:0016021 13/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X3KFV GO:0005886 13/21 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8X3KFV GO:0050909 13/21 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8X3KFW GO:0005524 27/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X3KFW GO:0004674 25/97 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8X3KFW GO:0004672 3/97 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8X3KFW GO:0004712 2/97 protein serine/threonine/tyrosine kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] EOG8X3KFW GO:0016772 2/97 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8X3KFW GO:0071011 1/97 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8X3KFW GO:0022008 1/97 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8X3KFW GO:0008360 1/97 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8X3KFW GO:0000398 1/97 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8X3KFW GO:0071013 1/97 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8X3KFW GO:0006468 1/97 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8X3KFW GO:0007155 1/97 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8HQH1R GO:0016020 1/50 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HQH1R GO:0016192 1/50 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8Z6529 GO:0005509 18/118 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8Z6529 GO:0005576 11/118 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z6529 GO:0030414 11/118 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8Z6529 GO:0051539 2/118 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8Z6529 GO:0008362 1/118 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8Z6529 GO:0007475 1/118 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG8Z6529 GO:0005201 1/118 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8Z6529 GO:0031012 1/118 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8Z6529 GO:0040005 1/118 chitin-based cuticle attachment to epithelium biological_process "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8Z6529 GO:0007424 1/118 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8Z6529 GO:0046331 1/118 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8KD91F GO:0006207 26/89 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG8KD91F GO:0004590 26/89 orotidine-5'-phosphate decarboxylase activity molecular_function "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599] EOG8KD91F GO:0044205 24/89 'de novo' UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] EOG8KD91F GO:0004588 23/89 orotate phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] EOG8KD91F GO:0005875 1/89 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8KD91F GO:0009116 1/89 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8KD91F GO:0006221 1/89 pyrimidine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8Q87B6 GO:0003676 81/261 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q87B6 GO:0046872 68/261 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Q87B6 GO:0008270 14/261 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Q87B6 GO:0005634 5/261 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Q87B6 GO:0005198 1/261 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8Q87B6 GO:0019953 1/261 sexual reproduction biological_process "A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546] EOG8Q87B6 GO:0030141 1/261 secretory granule cellular_component "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] EOG8Q87B6 GO:0005576 1/261 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8KD91N GO:0004197 14/39 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8KD91N GO:0006915 13/39 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8KD91K GO:0003824 9/64 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KD91K GO:0016301 2/64 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8KD91K GO:0004721 2/64 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG80P6QB GO:0005856 1/66 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG80P6QB GO:0009966 1/66 regulation of signal transduction biological_process "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] EOG80P6QB GO:0008360 1/66 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG80P6QB GO:0005198 1/66 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG80P6QB GO:0005737 1/66 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80P6QB GO:0005886 1/66 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8GMXDT GO:0007165 1/12 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8GMXDT GO:0005622 1/12 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG87WR3B GO:0008430 32/95 selenium binding molecular_function "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] EOG82588M GO:0003824 21/84 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG82588M GO:0046872 2/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KD91X GO:0000022 1/80 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG825885 GO:0005634 1/317 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG825885 GO:0005576 1/317 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG825885 GO:0003743 1/317 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG825885 GO:0050830 1/317 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG825885 GO:0032504 1/317 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG825885 GO:0002759 1/317 regulation of antimicrobial humoral response biological_process "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] EOG825885 GO:0050829 1/317 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG825885 GO:0005615 1/317 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG825880 GO:0004252 24/106 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG825880 GO:0008237 1/106 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG825880 GO:0016020 1/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG825880 GO:0008241 1/106 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG825880 GO:0006508 1/106 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG825880 GO:0008233 1/106 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8Z652P GO:0005234 3/56 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8Z652P GO:0016020 3/56 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z652P GO:0004970 3/56 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8Z652P GO:0015276 2/56 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8Z652P GO:0009593 2/56 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8Z652P GO:0036081 2/56 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8Z652P GO:0034220 2/56 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8Z652P GO:0016021 2/56 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z652P GO:0050909 1/56 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG87WR31 GO:0008152 1/101 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG81VNGV GO:0016874 2/32 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8RFP7V GO:0016021 12/199 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RFP7V GO:0007519 1/199 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG8RFP7V GO:0016020 1/199 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RFP7V GO:0007520 1/199 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8RFP7N GO:0030246 26/95 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8CVJMR GO:0016772 33/148 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8CVJMR GO:0016301 3/148 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8Q87BK GO:0005524 58/185 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Q87BK GO:0003677 33/185 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Q87BK GO:0004386 33/185 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8Q87BK GO:0003676 6/185 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q87BK GO:0017111 3/185 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8Q87BK GO:0005634 2/185 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Q87BK GO:0016740 2/185 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8Q87BK GO:0034454 1/185 microtubule anchoring at centrosome biological_process "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] EOG8Q87BK GO:0006355 1/185 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Q87BK GO:0007143 1/185 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8Q87BK GO:0005509 1/185 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8Q87BK GO:0006353 1/185 DNA-templated transcription, termination biological_process "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] EOG8Q87BK GO:0016021 1/185 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Q87BK GO:0008094 1/185 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8Q87BK GO:0000381 1/185 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8Q87BK GO:0007156 1/185 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8Q87BK GO:0007283 1/185 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8Q87BK GO:0005737 1/185 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Q87BK GO:0006200 1/185 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8CVJMV GO:0000166 3/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CVJMV GO:0003676 3/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CVJMV GO:0051301 3/103 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8CVJMV GO:0045842 1/103 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8CVJMV GO:0000398 1/103 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CVJMV GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CVJMV GO:0008054 1/103 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8CVJMV GO:0090302 1/103 APC-Cdc20 complex activity molecular_function "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] EOG8CVJMV GO:0009987 1/103 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8CVJMV GO:0005680 1/103 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG8CVJMV GO:0071011 1/103 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CVJMV GO:0000278 1/103 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8CVJMV GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CVJMV GO:0007067 1/103 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8KD919 GO:0005272 8/35 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8KD919 GO:0016021 5/35 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD919 GO:0016020 3/35 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VHNM9 GO:0004663 13/91 Rab geranylgeranyltransferase activity molecular_function "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] EOG8VHNM9 GO:0005968 13/91 Rab-protein geranylgeranyltransferase complex cellular_component "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217] EOG8VHNM9 GO:0006886 13/91 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8VHNM9 GO:0016740 2/91 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8VHNM9 GO:0007269 1/91 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8VHNM9 GO:0008021 1/91 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8VHNM9 GO:0005096 1/91 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8VHNM9 GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VHNM9 GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VHNM9 GO:0048471 1/91 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8VHNM9 GO:0000922 1/91 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8VHNM9 GO:0016192 1/91 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8VHNM9 GO:0005818 1/91 aster cellular_component "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] EOG8VHNM9 GO:0007049 1/91 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8W10WG GO:0005840 35/107 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8W10WG GO:0003735 34/107 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8W10WG GO:0006412 34/107 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8W10WG GO:0007052 1/107 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8W10WG GO:0000022 1/107 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8MD0DV GO:0004222 27/147 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8MD0DV GO:0008270 19/147 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MD0DV GO:0004190 1/147 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG80VZ4Q GO:0000139 1/92 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG80VZ4Q GO:0015031 1/92 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG80VZ4Q GO:0000301 1/92 retrograde transport, vesicle recycling within Golgi biological_process "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] EOG80VZ4Q GO:0070273 1/92 phosphatidylinositol-4-phosphate binding molecular_function "Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah] EOG80VZ4Q GO:0007224 1/92 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG80VZ4Q GO:0005794 1/92 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG80VZ4Q GO:0031985 1/92 Golgi cisterna cellular_component "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] EOG8HQH14 GO:0008270 1/114 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HQH11 GO:0004930 1/17 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8HQH11 GO:0016021 1/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FN711 GO:0008270 47/130 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FN711 GO:0004126 46/130 cytidine deaminase activity molecular_function "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] EOG8FN711 GO:0016787 1/130 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8K6JKH GO:0051056 2/110 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8K6JKH GO:0005622 2/110 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8K6JKH GO:0005096 2/110 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8K6JKH GO:0032851 1/110 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8K6JKH GO:0000139 1/110 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8K6JKH GO:0035418 1/110 protein localization to synapse biological_process "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] EOG8K6JKH GO:0060078 1/110 regulation of postsynaptic membrane potential biological_process "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef] EOG8K6JKH GO:0017112 1/110 Rab guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8K6JKH GO:0016021 1/110 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K6JKH GO:0017137 1/110 Rab GTPase binding molecular_function "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] EOG8K6JKH GO:0016023 1/110 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG8K6JKH GO:0045467 1/110 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8K6JKH GO:0005794 1/110 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8K6JKH GO:0007411 1/110 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8K6JKH GO:0050808 1/110 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG8K6JKH GO:0032483 1/110 regulation of Rab protein signal transduction biological_process "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] EOG8FN6Z7 GO:0003676 19/196 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J3ZZ8 GO:0003723 26/75 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8J3ZZ8 GO:0000178 25/75 exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases." [PMID:10465791] EOG8J3ZZ8 GO:0004527 3/75 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8J3ZZ8 GO:0010468 1/75 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8J3ZZ8 GO:0000176 1/75 nuclear exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] EOG8J3ZZ8 GO:0016787 1/75 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8J3ZZ8 GO:0005737 1/75 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XD65W GO:0070526 25/104 tRNA threonylcarbamoyladenosine modification biological_process "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706] EOG8XD65W GO:0016747 25/104 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8XD65W GO:0046872 25/104 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XD65W GO:0005634 25/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XD65W GO:0005737 25/104 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XD65W GO:0016787 2/104 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XD65W GO:0022008 1/104 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8XD65W GO:0008237 1/104 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8SJ7WV GO:0006412 1/19 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8SJ7WV GO:0005840 1/19 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8SJ7WV GO:0003735 1/19 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG85TG21 GO:0003676 23/101 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85TG21 GO:0004527 19/101 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG85TG21 GO:0004535 3/101 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG85TG21 GO:0008233 3/101 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG85TG21 GO:0004221 2/101 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG85TG21 GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85TG21 GO:0000289 1/101 nuclear-transcribed mRNA poly(A) tail shortening biological_process "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] EOG8SJ7W6 GO:0003676 14/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SJ7W6 GO:0008270 14/99 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SJ7W6 GO:0004504 1/99 peptidylglycine monooxygenase activity molecular_function "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] EOG8SJ7W6 GO:0005507 1/99 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8SJ7W6 GO:0006518 1/99 peptide metabolic process biological_process "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators] EOG8SJ7W6 GO:0016020 1/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8J13PH GO:0006355 1/82 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8J13PH GO:0048188 1/82 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG8J13PH GO:0006351 1/82 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J13PH GO:0046427 1/82 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8J13PH GO:0051568 1/82 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8J13PH GO:0003676 1/82 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J13PH GO:0044666 1/82 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8J13PJ GO:0016021 33/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J13PJ GO:0046923 33/103 ER retention sequence binding molecular_function "Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] EOG8J13PJ GO:0006621 33/103 protein retention in ER lumen biological_process "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] EOG8J13PJ GO:0015031 29/103 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8J13PJ GO:0005783 29/103 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8J13PJ GO:0046872 1/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8J13PJ GO:0003676 1/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8P8HZ7 GO:0004252 2/19 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8P8HZ0 GO:0016020 5/26 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8P8HZ0 GO:0005234 5/26 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8P8HZ0 GO:0004970 5/26 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8J13PM GO:0006506 24/76 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG8J13PM GO:0016758 23/76 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8J13PM GO:0016021 2/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J13PM GO:0005789 2/76 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8J13PM GO:0097502 1/76 mannosylation biological_process "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm] EOG8J13PM GO:0000030 1/76 mannosyltransferase activity molecular_function "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm] EOG8P8HZ2 GO:0007616 1/83 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8P8HZ2 GO:0007274 1/83 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8WWV27 GO:0006811 2/34 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8WWV27 GO:0016021 2/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FN6ZF GO:0016020 1/20 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FN6ZF GO:0007156 1/20 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8FN6ZF GO:0005509 1/20 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XD659 GO:0016021 1/109 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FBM7V GO:0004298 35/96 threonine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8FBM7V GO:0005839 35/96 proteasome core complex cellular_component "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] EOG8FBM7V GO:0051603 34/96 proteolysis involved in cellular protein catabolic process biological_process "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] EOG8FBM7V GO:0005634 29/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FBM7V GO:0005737 29/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FBM7V GO:0051297 1/96 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8FBM7V GO:0006974 1/96 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8FBM7V GO:0009987 1/96 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8FBM7V GO:0022008 1/96 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8FBM7V GO:0000022 1/96 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8FBM7V GO:0007052 1/96 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8FBM7V GO:0008283 1/96 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8FBM7V GO:0043161 1/96 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG8MKQWW GO:0005634 3/12 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MKQWW GO:0008270 3/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MKQWW GO:0003676 3/12 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FBM7H GO:0004970 1/31 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8FBM7H GO:0016020 1/31 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FBM7H GO:0005234 1/31 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG83FKB4 GO:0016779 24/97 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG83FKB4 GO:0003983 3/97 UTP:glucose-1-phosphate uridylyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892] EOG834ZNQ GO:0005089 4/37 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG84TRPF GO:0005524 26/204 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84TRPF GO:0004672 23/204 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG84TRPF GO:0004683 2/204 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG84TRPF GO:0004674 1/204 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG84TRPF GO:0016081 1/204 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG84TRPF GO:0040012 1/204 regulation of locomotion biological_process "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] EOG84TRPF GO:0031594 1/204 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG84TRPF GO:0016301 1/204 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG84TRPF GO:0008049 1/204 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG84TRPF GO:0046928 1/204 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG84TRPF GO:0007628 1/204 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG84TRPF GO:0061174 1/204 type I terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] EOG84TRPF GO:0007274 1/204 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG84TRPF GO:0007616 1/204 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG84TRPF GO:0042043 1/204 neurexin family protein binding molecular_function "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512] EOG84TRPF GO:0046331 1/204 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG84TRPF GO:2000331 1/204 regulation of terminal button organization biological_process "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] EOG84TRPF GO:1900073 1/204 regulation of neuromuscular synaptic transmission biological_process "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG84TRPF GO:0008360 1/204 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG84TRPF GO:0016080 1/204 synaptic vesicle targeting biological_process "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] EOG84TRPF GO:0004385 1/204 guanylate kinase activity molecular_function "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] EOG84TRPF GO:0007298 1/204 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG84TRPF GO:0008344 1/204 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG84TRPF GO:1900244 1/204 positive regulation of synaptic vesicle endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] EOG84TRPF GO:0005886 1/204 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84TRPF GO:0048488 1/204 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG84TRPF GO:0040011 1/204 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG84TRPF GO:0006468 1/204 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG84TRPF GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84TRPF GO:0007163 1/204 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG84TRPF GO:0072375 1/204 medium-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375] EOG84TRPF GO:0007615 1/204 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG84TRPF GO:0007269 1/204 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG84TRPF GO:0005954 1/204 calcium- and calmodulin-dependent protein kinase complex cellular_component "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] EOG84TRPF GO:0004713 1/204 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG84TRPF GO:0008582 1/204 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG84TRPF GO:0007155 1/204 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG81ZHR9 GO:0030170 31/121 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81ZHR9 GO:0008483 26/121 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG81ZHR9 GO:0004587 5/121 ornithine-oxo-acid transaminase activity molecular_function "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] EOG81ZHR9 GO:0005759 2/121 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG81ZHR9 GO:0055129 2/121 L-proline biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] EOG81ZHR9 GO:0022008 1/121 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG81ZHR9 GO:0005739 1/121 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG85XBCR GO:0007018 1/69 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG85XBCR GO:0006200 1/69 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG85XBCR GO:0005875 1/69 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG85XBCR GO:0042623 1/69 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG85XBCR GO:0030286 1/69 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG86X1RX GO:0042981 1/29 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG86X1RX GO:0005622 1/29 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8B2WBV GO:0003824 5/146 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8B2WBV GO:0016787 2/146 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8B2WBV GO:0005789 1/146 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8B2WBV GO:0030433 1/146 ER-associated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] EOG8B2WBV GO:0006950 1/146 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8B2WBV GO:0033961 1/146 cis-stilbene-oxide hydrolase activity molecular_function "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] EOG8B2WBV GO:0008233 1/146 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8B2WBV GO:0016021 1/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B2WBV GO:0006515 1/146 misfolded or incompletely synthesized protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] EOG86X1RS GO:0046872 2/18 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86X1RS GO:0003676 2/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84F8QM GO:0005975 94/390 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG84F8QM GO:0004553 93/390 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG84F8QM GO:0008422 1/390 beta-glucosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] EOG84F8QM GO:0008970 1/390 phosphatidylcholine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] EOG84F8QM GO:0052740 1/390 1-acyl-2-lysophosphatidylserine acylhydrolase activity molecular_function "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] EOG84F8QM GO:0052739 1/390 phosphatidylserine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034] EOG86X1RP GO:0003700 1/19 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86X1RP GO:0043565 1/19 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG86X1RP GO:0005634 1/19 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JT2Q3 GO:0003676 2/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JT2Q3 GO:0046872 1/6 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JT2Q3 GO:0008270 1/6 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8JT2Q3 GO:0005634 1/6 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V9X5D GO:0003676 7/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B2WB2 GO:0008270 3/35 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B2WB2 GO:0035556 1/35 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8B2WB2 GO:0046872 1/35 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MKQW4 GO:0008157 1/118 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG83FKBZ GO:0016021 40/109 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83FKBZ GO:0006810 28/109 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG83FKBZ GO:0055085 11/109 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG83FKBZ GO:0005739 2/109 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG83FKBZ GO:0015117 1/109 thiosulfate transmembrane transporter activity molecular_function "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai] EOG83FKBZ GO:0015729 1/109 oxaloacetate transport biological_process "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG83FKBZ GO:0015140 1/109 malate transmembrane transporter activity molecular_function "Enables the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] EOG83FKBZ GO:1902356 1/109 oxaloacetate(2-) transmembrane transport biological_process "The directed movement of oxaloacetate(2-) across a membrane." [GOC:dph, GOC:TermGenie, PMID:18682385] EOG83FKBZ GO:1902358 1/109 sulfate transmembrane transport biological_process "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] EOG83FKBZ GO:0008272 1/109 sulfate transport biological_process "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG83FKBZ GO:0015131 1/109 oxaloacetate transmembrane transporter activity molecular_function "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai] EOG83FKBZ GO:0015116 1/109 sulfate transmembrane transporter activity molecular_function "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] EOG83FKBZ GO:0015141 1/109 succinate transmembrane transporter activity molecular_function "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732] EOG83FKBZ GO:0071422 1/109 succinate transmembrane transport biological_process "A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG83FKBZ GO:0071423 1/109 malate transmembrane transport biological_process "A process in which a malate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG83FKBZ GO:0035435 1/109 phosphate ion transmembrane transport biological_process "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] EOG83FKBZ GO:0005315 1/109 inorganic phosphate transmembrane transporter activity molecular_function "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] EOG83FKBZ GO:0015709 1/109 thiosulfate transport biological_process "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG834ZPQ GO:0005634 23/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG834ZPQ GO:0008270 23/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG834ZPQ GO:0003676 2/86 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85MQKS GO:0004867 66/258 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG85MQKS GO:0004064 3/258 arylesterase activity molecular_function "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] EOG85MQKS GO:0005576 1/258 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QRKKZ GO:0008138 24/91 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8QRKKZ GO:0006470 24/91 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG883GNT GO:0003964 338/1363 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG883GNT GO:0003723 333/1363 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG883GNT GO:0008270 44/1363 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG883GNT GO:0003676 19/1363 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GNT GO:0004519 4/1363 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG883GNT GO:0004523 3/1363 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG883GNT GO:0006511 2/1363 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG883GNT GO:0046872 2/1363 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG883GNT GO:0005634 1/1363 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG883GNT GO:0016020 1/1363 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG883GNT GO:0034450 1/1363 ubiquitin-ubiquitin ligase activity molecular_function "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] EOG883GNT GO:0005524 1/1363 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG883GNT GO:0004674 1/1363 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG883GNT GO:0015074 1/1363 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG883GNT GO:0006281 1/1363 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG883GNT GO:0000723 1/1363 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG883GNT GO:0003677 1/1363 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG883GNT GO:0000786 1/1363 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG883GNT GO:0003678 1/1363 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG883GNT GO:0016758 1/1363 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG883GNT GO:0006334 1/1363 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG883GNT GO:0000151 1/1363 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG84XMZQ GO:0005549 69/258 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NGK1D GO:0008270 118/444 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NGK1D GO:0008237 118/444 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8NGK1D GO:0004177 19/444 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8NGK1D GO:0033227 1/444 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8NGK1D GO:0004463 1/444 leukotriene-A4 hydrolase activity molecular_function "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327] EOG8NGK1D GO:0006508 1/444 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8NGK1G GO:0004725 25/171 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8NGK1G GO:0050254 2/171 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8NGK1G GO:0001700 1/171 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8NGK1G GO:0005001 1/171 transmembrane receptor protein tyrosine phosphatase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8NGK1G GO:0008201 1/171 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8NGK1G GO:0048675 1/171 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8NGK1G GO:0005925 1/171 focal adhesion cellular_component "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] EOG8NGK1G GO:0005515 1/171 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NGK1G GO:0005875 1/171 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NGK1G GO:0016021 1/171 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NGK1G GO:0007412 1/171 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8NGK1G GO:0048841 1/171 regulation of axon extension involved in axon guidance biological_process "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] EOG8NGK1G GO:0007399 1/171 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8NGK1G GO:0035335 1/171 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8NGK1G GO:0030424 1/171 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8NGK1G GO:0032093 1/171 SAM domain binding molecular_function "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] EOG8NGK1G GO:0005886 1/171 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NGK1G GO:0048477 1/171 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8NGK1G GO:0007155 1/171 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8NGK1G GO:0008045 1/171 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8NGK1G GO:0045467 1/171 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8NGK1G GO:0007411 1/171 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8NGK1G GO:0051124 1/171 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8NGK1G GO:0008594 1/171 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8NGK1G GO:0008360 1/171 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8NGK1G GO:0016162 1/171 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG8NGK1G GO:0031290 1/171 retinal ganglion cell axon guidance biological_process "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] EOG8NGK1G GO:0006470 1/171 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG83N9T2 GO:0006783 26/87 heme biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] EOG83N9T2 GO:0004325 26/87 ferrochelatase activity molecular_function "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587] EOG83N9T2 GO:0005875 1/87 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG83N9T2 GO:0051537 1/87 2 iron, 2 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG83N9T2 GO:0005743 1/87 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG83N9T2 GO:0046872 1/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M681H GO:0005634 28/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M681H GO:0006355 1/96 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8M681H GO:0035102 1/96 PRC1 complex cellular_component "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] EOG8M681H GO:0005730 1/96 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8M681H GO:0016458 1/96 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG8M681H GO:0000785 1/96 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8M681H GO:0001047 1/96 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG8M681H GO:0045892 1/96 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8M681H GO:0035186 1/96 syncytial blastoderm mitotic cell cycle biological_process "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] EOG8M681H GO:0005725 1/96 intercalary heterochromatin cellular_component "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] EOG8M681H GO:0003682 1/96 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8M681H GO:0022008 1/96 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8M681H GO:0035064 1/96 methylated histone binding molecular_function "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] EOG8M681H GO:0016787 1/96 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8M681H GO:0042060 1/96 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8M681H GO:0007385 1/96 specification of segmental identity, abdomen biological_process "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] EOG8M681H GO:2001229 1/96 negative regulation of response to gamma radiation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol] EOG8M681H GO:0016322 1/96 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8QJV2V GO:0008146 160/572 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QJV2V GO:0004027 62/572 alcohol sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] EOG8QJV2V GO:0004304 10/572 estrone sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] EOG8QJV2V GO:0005829 3/572 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QJV2V GO:0051923 3/572 sulfation biological_process "The addition of a sulfate group to a molecule." [http://www.onelook.com] EOG8QJV2V GO:0006805 2/572 xenobiotic metabolic process biological_process "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] EOG8QJV2V GO:0004062 1/572 aryl sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] EOG8QJV2Z GO:0007606 16/1207 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0005515 9/1207 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QJV2Z GO:0016021 3/1207 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV2Z GO:0008039 1/1207 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8QJV2Z GO:0050914 1/1207 sensory perception of salty taste biological_process "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0002115 1/1207 store-operated calcium entry biological_process "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] EOG8QJV2Z GO:0035199 1/1207 salt aversion biological_process "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] EOG8QJV2Z GO:0048149 1/1207 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8QJV2Z GO:0005886 1/1207 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TXF5Z GO:0005267 9/49 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8TXF5Z GO:0016021 9/49 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XPSW6 GO:0008270 224/674 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XPSW6 GO:0004222 224/674 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8XPSW6 GO:0006909 1/674 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8XPSW6 GO:0016020 1/674 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XPSW6 GO:0004175 1/674 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8XPSW6 GO:0032504 1/674 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8XPSW6 GO:0006508 1/674 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8XPSW6 GO:0046331 1/674 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XPSW6 GO:0005615 1/674 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8XPSW6 GO:0022008 1/674 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84XMZF GO:0005509 38/148 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG84XMZF GO:0032440 4/148 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG84XMZF GO:0046331 1/148 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG84XMZF GO:0016056 1/148 rhodopsin mediated signaling pathway biological_process "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] EOG84XMZF GO:0031476 1/148 myosin VI complex cellular_component "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG84XMZF GO:0051533 1/148 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG84XMZF GO:0007052 1/148 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG84XMZF GO:2001020 1/148 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG84XMZF GO:0005737 1/148 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84XMZF GO:0042052 1/148 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG84XMZF GO:0016028 1/148 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG84XMZF GO:0072499 1/148 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG84XMZF GO:0051383 1/148 kinetochore organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG84XMZF GO:0005875 1/148 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG84XMZF GO:0005516 1/148 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG84XMZF GO:0016060 1/148 metarhodopsin inactivation biological_process "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] EOG84XMZF GO:0032036 1/148 myosin heavy chain binding molecular_function "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah] EOG84XMZF GO:0016059 1/148 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG84XMZF GO:0007099 1/148 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG84XMZF GO:0070855 1/148 myosin VI head/neck binding molecular_function "Interacting selectively and non-covalently with the head/neck region of a myosin VI heavy chain." [GOC:sart] EOG84XMZF GO:0007605 1/148 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG84XMZF GO:0030048 1/148 actin filament-based movement biological_process "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] EOG84XMZF GO:0046716 1/148 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG84XMZF GO:0031489 1/148 myosin V binding molecular_function "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG84XMZF GO:0005814 1/148 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG84XMZF GO:0030496 1/148 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG84XMZF GO:0016061 1/148 regulation of light-activated channel activity biological_process "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] EOG84XMZF GO:0031475 1/148 myosin V complex cellular_component "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG84XMZF GO:0016062 1/148 adaptation of rhodopsin mediated signaling biological_process "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] EOG84XMZF GO:0005819 1/148 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG84XMZF GO:0005515 1/148 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84XMZF GO:0000922 1/148 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG84XMZF GO:0006468 1/148 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8F4VRH GO:0008270 24/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F4VRH GO:0003676 1/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KWN78 GO:0046872 26/90 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KWN78 GO:0003676 25/90 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KWN78 GO:0001654 1/90 eye development biological_process "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] EOG8KWN78 GO:0007423 1/90 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8KWN78 GO:0001078 1/90 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8KWN78 GO:0045944 1/90 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8KWN78 GO:0042683 1/90 negative regulation of compound eye cone cell fate specification biological_process "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] EOG8KWN78 GO:0001700 1/90 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8KWN78 GO:0007458 1/90 progression of morphogenetic furrow involved in compound eye morphogenesis biological_process "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] EOG8KWN78 GO:0048813 1/90 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8KWN78 GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KWN78 GO:0005634 1/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8KWN78 GO:0000122 1/90 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8KWN78 GO:0007422 1/90 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8KWN78 GO:0043565 1/90 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8KWN78 GO:0009612 1/90 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG8KWN78 GO:0006366 1/90 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8KWN78 GO:0003705 1/90 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8X9B0N GO:0003676 2/429 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X9B0N GO:0003899 1/429 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8X9B0N GO:0003677 1/429 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X9B0N GO:0006351 1/429 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8X9B0N GO:0031012 1/429 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8X9B0N GO:0004222 1/429 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8X9B0N GO:0008270 1/429 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F4VRB GO:0004970 27/163 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8F4VRB GO:0005234 27/163 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8F4VRB GO:0016020 20/163 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8F4VRB GO:0016021 9/163 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F4VRB GO:0005215 8/163 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8F4VRB GO:0015276 2/163 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8F4VRB GO:0036081 2/163 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8F4VRB GO:0034220 2/163 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8F4VRB GO:0009593 2/163 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8F4VRC GO:0045017 6/108 glycerolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] EOG8F4VRC GO:0004144 6/108 diacylglycerol O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] EOG8KWN71 GO:0005737 24/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8KWN71 GO:0017183 24/84 peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] EOG8KWN71 GO:0006909 1/84 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KWN70 GO:0042765 12/59 GPI-anchor transamidase complex cellular_component "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] EOG8KWN70 GO:0016255 12/59 attachment of GPI anchor to protein biological_process "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] EOG82FVXT GO:0004345 26/101 glucose-6-phosphate dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] EOG82FVXT GO:0050661 26/101 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG82FVXT GO:0006098 26/101 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG82FVXT GO:0051156 3/101 glucose 6-phosphate metabolic process biological_process "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] EOG82FVXT GO:0006739 3/101 NADP metabolic process biological_process "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] EOG8F4VRZ GO:0007229 3/85 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8F4VRZ GO:0051298 1/85 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8F4VRZ GO:0046872 1/85 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82FVXS GO:0016758 251/467 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG82FVXS GO:0015020 15/467 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG82FVXS GO:0030259 7/467 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG82FVXS GO:0016999 4/467 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG82FVXS GO:0030246 4/467 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG82FVXS GO:0003851 1/467 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] EOG8GJ23T GO:0003676 3/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GJ23T GO:0046872 2/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GJ23T GO:0008270 1/13 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ23T GO:0005634 1/13 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X9B0X GO:0000062 71/241 fatty-acyl-CoA binding molecular_function "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] EOG8X9B0X GO:0034464 24/241 BBSome cellular_component "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030] EOG8X9B0X GO:0035058 24/241 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG8X9B0X GO:0004402 2/241 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8X9B0X GO:0042384 1/241 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8X9B0X GO:0008289 1/241 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8X9B0X GO:0006810 1/241 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8X9B0X GO:0005929 1/241 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8X9B0X GO:0042049 1/241 cellular acyl-CoA homeostasis biological_process "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb] EOG8X9B0X GO:0004165 1/241 dodecenoyl-CoA delta-isomerase activity molecular_function "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] EOG8KWN7X GO:0005097 22/84 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG808QNW GO:0016021 2/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG808QNW GO:0055085 2/27 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8GJ238 GO:0004252 2/21 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GJ237 GO:0016021 48/257 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GJ237 GO:0003917 24/257 DNA topoisomerase type I activity molecular_function "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] EOG8GJ237 GO:0003677 24/257 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GJ237 GO:0006265 24/257 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG8GJ237 GO:0005694 23/257 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8GJ237 GO:0008270 22/257 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ237 GO:0042246 1/257 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8GJ237 GO:0006909 1/257 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8GJ237 GO:0005739 1/257 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8GJ237 GO:0005634 1/257 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GJ237 GO:0003916 1/257 DNA topoisomerase activity molecular_function "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] EOG8GJ237 GO:0005524 1/257 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GJ237 GO:0050829 1/257 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8GJ237 GO:0004185 1/257 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GJ237 GO:0000002 1/257 mitochondrial genome maintenance biological_process "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] EOG8GJ237 GO:0048589 1/257 developmental growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] EOG8GJ237 GO:0005215 1/257 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8GJ237 GO:0035010 1/257 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8GJ237 GO:0000724 1/257 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG8X9B08 GO:0019239 1/4 deaminase activity molecular_function "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] EOG83N9TB GO:0005634 2/24 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83N9TB GO:0008270 2/24 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M6819 GO:0032312 2/15 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8M6819 GO:0008270 2/15 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M6819 GO:0008060 2/15 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8Z38VR GO:0016021 33/157 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z38VR GO:0005432 32/157 calcium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] EOG8Z38VR GO:0007154 23/157 cell communication biological_process "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] EOG8Z38VR GO:0005509 1/157 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8Z38VR GO:0035725 1/157 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8Z38VR GO:0055085 1/157 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8Z38VR GO:0007602 1/157 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG83N9TJ GO:0005506 404/1184 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83N9TJ GO:0020037 404/1184 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83N9TJ GO:0016705 391/1184 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83N9TJ GO:0004497 374/1184 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83N9TJ GO:0005789 17/1184 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG83N9TJ GO:0070330 6/1184 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG83N9TJ GO:0052869 6/1184 arachidonic acid omega-hydroxylase activity molecular_function "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041] EOG83N9TJ GO:0018685 6/1184 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG83N9TJ GO:0016539 3/1184 intein-mediated protein splicing biological_process "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] EOG83N9TJ GO:0007165 2/1184 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG83N9TJ GO:0005622 2/1184 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83N9TJ GO:0007618 1/1184 mating biological_process "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] EOG83N9TJ GO:0005201 1/1184 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG83N9TJ GO:0005581 1/1184 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG83N9TJ GO:0050051 1/1184 leukotriene-B4 20-monooxygenase activity molecular_function "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] EOG83N9TJ GO:0052871 1/1184 alpha-tocopherol omega-hydroxylase activity molecular_function "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] EOG83N9TJ GO:0006629 1/1184 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG83N9TJ GO:0005737 1/1184 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83N9TJ GO:0005811 1/1184 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG83N9TS GO:0016021 1/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83N9TS GO:0017080 1/63 sodium channel regulator activity molecular_function "Modulates the activity of a sodium channel." [GOC:mah] EOG83N9TS GO:0002028 1/63 regulation of sodium ion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] EOG8Z38VB GO:0016020 41/234 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z38VB GO:0008654 41/234 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8Z38VB GO:0003841 41/234 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] EOG8Z38VB GO:0016746 6/234 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Z38VB GO:0048149 1/234 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8QJV27 GO:0016787 6/51 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8Z38VN GO:0004252 2/9 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8Z38VN GO:0003824 1/9 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG84XN03 GO:0015016 2/25 [heparan sulfate]-glucosamine N-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8] EOG84XN03 GO:0016787 2/25 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8QFZTJ GO:0008234 32/101 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8QFZTJ GO:0005215 2/101 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8QFZTJ GO:0005576 2/101 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QFZTJ GO:0005875 1/101 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8QFZTJ GO:0005811 1/101 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8STVJJ GO:0009435 27/103 NAD biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] EOG8STVJJ GO:0016779 24/103 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8STVJJ GO:0000309 3/103 nicotinamide-nucleotide adenylyltransferase activity molecular_function "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] EOG8STVJJ GO:0051082 1/103 unfolded protein binding molecular_function "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] EOG8STVJJ GO:0045494 1/103 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG8STVJJ GO:0097062 1/103 dendritic spine maintenance biological_process "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] EOG82NMG9 GO:0005509 105/381 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG82NMG9 GO:0043565 1/381 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82NMG9 GO:0032440 1/381 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG82NMG9 GO:0003700 1/381 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z653R GO:0016192 26/83 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8Z653R GO:0016020 25/83 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z653R GO:0006886 9/83 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8Z653R GO:0005484 1/83 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG8Z653R GO:0035088 1/83 establishment or maintenance of apical/basal cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] EOG8Z653R GO:0007269 1/83 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8Z653R GO:0005769 1/83 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8Z653R GO:0008285 1/83 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8Z653R GO:0045807 1/83 positive regulation of endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8Z653R GO:0035073 1/83 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG8Z653R GO:0005515 1/83 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8Z653R GO:0035264 1/83 multicellular organism growth biological_process "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] EOG8Z653R GO:0034058 1/83 endosomal vesicle fusion biological_process "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] EOG8Z653R GO:0016081 1/83 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG8Z653R GO:0005886 1/83 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8Z653R GO:0048227 1/83 plasma membrane to endosome transport biological_process "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid] EOG8M3CSC GO:0005811 1/109 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG808QRG GO:0016740 1/23 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8D55FW GO:0080019 1/13 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8STVJQ GO:0008236 11/38 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8STVJQ GO:0004180 6/38 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8KWN99 GO:0005524 71/292 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KWN99 GO:0004674 64/292 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8KWN99 GO:0004672 7/292 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8KWN99 GO:0004702 3/292 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8KWN99 GO:0005737 3/292 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8KWN99 GO:0006468 3/292 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8KWN99 GO:0023014 2/292 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8KWN99 GO:0005856 1/292 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8KWN99 GO:0007015 1/292 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8KWN99 GO:0007520 1/292 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8KWN99 GO:0005912 1/292 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8KWN99 GO:0097482 1/292 muscle cell postsynaptic density cellular_component "A postsynaptic density that is part of a muscle cell." [GOC:pr] EOG8KWN99 GO:0045887 1/292 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8KWN99 GO:0019991 1/292 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8KWN99 GO:0045315 1/292 positive regulation of compound eye photoreceptor development biological_process "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG8KWN99 GO:0007010 1/292 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8KWN99 GO:0007254 1/292 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8KWN99 GO:0005913 1/292 cell-cell adherens junction cellular_component "An adherens junction which connects a cell to another cell." [GOC:hb] EOG8KWN99 GO:0008360 1/292 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8KWN99 GO:0000187 1/292 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG8KWN99 GO:0046331 1/292 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8KWN99 GO:0007391 1/292 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8KWN99 GO:0016601 1/292 Rac protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] EOG8KWN99 GO:0007411 1/292 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8KWN99 GO:0050803 1/292 regulation of synapse structure or activity biological_process "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] EOG8KWN99 GO:0005886 1/292 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KWN99 GO:0016328 1/292 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG8KWN99 GO:0048749 1/292 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8KWN99 GO:0005515 1/292 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KWN99 GO:0005925 1/292 focal adhesion cellular_component "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] EOG8KWN99 GO:0016319 1/292 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8KWN99 GO:0007030 1/292 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8KWN99 GO:0007409 1/292 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8KWN99 GO:0007155 1/292 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8KWN99 GO:0030036 1/292 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8KWN99 GO:0050770 1/292 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG8KWN99 GO:0045792 1/292 negative regulation of cell size biological_process "Any process that reduces cell size." [GOC:go_curators] EOG8KWN99 GO:0001751 1/292 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG869T89 GO:0016021 50/144 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG869T89 GO:0004930 47/144 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG869T89 GO:0004715 3/144 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG869T89 GO:0007198 2/144 adenylate cyclase-inhibiting serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] EOG869T89 GO:0007208 2/144 phospholipase C-activating serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] EOG869T89 GO:0007210 2/144 serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] EOG869T89 GO:0004993 2/144 serotonin receptor activity molecular_function "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] EOG869T89 GO:0001586 2/144 Gi/o-coupled serotonin receptor activity molecular_function "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247] EOG869T89 GO:0008227 2/144 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG869T89 GO:0005886 2/144 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG869T89 GO:0007615 1/144 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG869T89 GO:0004977 1/144 melanocortin receptor activity molecular_function "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] EOG869T89 GO:0045187 1/144 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG869T89 GO:0009649 1/144 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG89CSQD GO:0016597 1/69 amino acid binding molecular_function "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] EOG89CSQD GO:0002121 1/69 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG89CSQD GO:0042332 1/69 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG89CSQD GO:0008152 1/69 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8H48HQ GO:0004402 1/81 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8W6RC0 GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8W6RC0 GO:0038032 1/11 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG8W6RC0 GO:0004672 1/11 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8H48HH GO:0009235 4/153 cobalamin metabolic process biological_process "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] EOG8H48HH GO:0005739 4/153 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8H48HH GO:0048488 1/153 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8H48HH GO:0030036 1/153 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8W10VQ GO:0003676 9/29 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W10VQ GO:0046872 9/29 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8W10VX GO:0003747 23/68 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG8J6V5M GO:0005886 2/19 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8J6V5M GO:0016021 2/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J6V5M GO:0004984 2/19 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8J6V5M GO:0004930 2/19 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8J6V5M GO:0005549 2/19 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8BK7K5 GO:0003723 83/200 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BK7K5 GO:0016607 4/200 nuclear speck cellular_component "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] EOG8BK7K5 GO:0005737 1/200 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BK7K5 GO:0071013 1/200 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8BK7K5 GO:0000398 1/200 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8BK7K5 GO:0005634 1/200 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BK7K5 GO:0000381 1/200 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8BK7K5 GO:0022008 1/200 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8BK7K5 GO:0071011 1/200 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8BK7K5 GO:0006915 1/200 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8BK7K5 GO:0007288 1/200 sperm axoneme assembly biological_process "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684] EOG8BK7K5 GO:0010608 1/200 posttranscriptional regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] EOG8BK7K5 GO:0046331 1/200 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8BK7K5 GO:0007291 1/200 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8BK7K4 GO:0006366 2/85 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8BK7K4 GO:0006357 2/85 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8BK7K4 GO:0016592 2/85 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8BK7K4 GO:0005634 2/85 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BK7K4 GO:0001104 2/85 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8BK7K4 GO:0006355 1/85 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BK7K4 GO:0005515 1/85 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8BK7K4 GO:0006351 1/85 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8BK7K3 GO:0008061 2/17 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8BK7K3 GO:0005576 2/17 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BK7K3 GO:0006030 2/17 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG89CSQ4 GO:0042052 1/112 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG89CSQ4 GO:0032414 1/112 positive regulation of ion transmembrane transporter activity biological_process "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] EOG89CSQ4 GO:0046716 1/112 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG89CSQ4 GO:0045475 1/112 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG89CSQ4 GO:0072499 1/112 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG81RSB0 GO:0003968 1/78 RNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] EOG8S7N3Z GO:0003676 32/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S7N3Z GO:0016788 32/100 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8S7N3Z GO:0016442 26/100 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG8S7N3Z GO:0031047 25/100 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8S7N3Z GO:0005811 1/100 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8S7N3Z GO:0005875 1/100 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG82NMGT GO:0008233 1/20 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8D55F0 GO:0005634 25/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55F0 GO:0007049 25/88 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8D55F0 GO:0006281 25/88 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8D55F0 GO:0017111 2/88 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8D55F0 GO:0005524 2/88 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82589C GO:0006351 20/101 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82589C GO:0003677 20/101 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82589C GO:0005634 20/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82589C GO:0006355 20/101 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82589C GO:0007275 19/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG82589C GO:0007423 1/101 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG82589C GO:0007169 1/101 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG82589C GO:0048800 1/101 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG82589C GO:0007476 1/101 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG82589C GO:0007480 1/101 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG82589C GO:0016020 1/101 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82589C GO:0008049 1/101 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG82589C GO:0051536 1/101 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG82589C GO:0004714 1/101 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG82589C GO:0030154 1/101 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG82589C GO:0007399 1/101 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG82589C GO:0009415 1/101 response to water biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] EOG82589C GO:0008343 1/101 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG82589C GO:0005524 1/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JQ6D9 GO:0019464 27/87 glycine decarboxylation via glycine cleavage system biological_process "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] EOG8JQ6D9 GO:0005960 27/87 glycine cleavage complex cellular_component "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] EOG8JQ6D9 GO:0005739 1/87 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8JQ6D9 GO:0035220 1/87 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG89PDCR GO:0006520 45/105 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG89PDCR GO:0004067 26/105 asparaginase activity molecular_function "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] EOG89PDCR GO:0004622 3/105 lysophospholipase activity molecular_function "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] EOG80P6PV GO:0005634 2/367 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80P6PV GO:0032440 2/367 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG80P6PV GO:0007411 2/367 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG80P6PV GO:0003705 2/367 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG80P6PV GO:0006366 2/367 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG80P6PV GO:0045944 2/367 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80P6PV GO:0007417 2/367 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG80P6PV GO:0007399 1/367 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG80P6PV GO:0009950 1/367 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG80P6PV GO:0006355 1/367 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG80P6PV GO:0006909 1/367 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG80P6PV GO:0010468 1/367 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG80P6PV GO:0007420 1/367 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG80P6PV GO:0008134 1/367 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG80P6PV GO:0007442 1/367 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG80P6PV GO:0007350 1/367 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG80P6PV GO:0070983 1/367 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG80P6PV GO:0005737 1/367 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80P6PV GO:0060810 1/367 intracellular mRNA localization involved in pattern specification process biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] EOG80P6PV GO:0030111 1/367 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG80P6PV GO:0002168 1/367 instar larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG80P6PV GO:0003677 1/367 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80P6PV GO:0035120 1/367 post-embryonic appendage morphogenesis biological_process "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] EOG80P6PV GO:0008301 1/367 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG80P6PV GO:0006357 1/367 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80P6PV GO:0043565 1/367 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG80P6PV GO:0003700 1/367 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG80P6PV GO:0005515 1/367 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80P6PV GO:0000122 1/367 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80P6PV GO:0003730 1/367 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG80P6PV GO:0031490 1/367 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG80P6PV GO:0045893 1/367 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8G7FCT GO:0003676 104/318 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G7FCT GO:0016747 1/318 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8G7FCT GO:0046872 1/318 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81C99X GO:0005975 20/89 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG81C99X GO:0004415 20/89 hyalurononglucosaminidase activity molecular_function "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] EOG81C99X GO:0006952 16/89 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8J9QCZ GO:0043565 1/88 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8J9QCZ GO:0006351 1/88 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J9QCZ GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J9QCZ GO:0003700 1/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8J9QCZ GO:0035859 1/88 Seh1-associated complex cellular_component "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] EOG8J9QCZ GO:0008270 1/88 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G7FCH GO:0016021 12/69 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FCH GO:0004984 11/69 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8G7FCH GO:0005549 11/69 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8G7FCH GO:0004930 10/69 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8G7FCH GO:0005886 6/69 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8G7FCH GO:0050909 2/69 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8G7FCH GO:0016020 1/69 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NCPVR GO:0004518 1/47 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8NCPVR GO:0006281 1/47 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8NCPVP GO:0005576 1/22 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NCPVP GO:0005515 1/22 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81C998 GO:0008237 1/12 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG81C998 GO:0008270 1/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8KD90X GO:0016787 24/120 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8KD90X GO:0003824 6/120 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KD90X GO:0046872 3/120 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KD90X GO:0004725 3/120 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG87WR2V GO:0003676 4/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87WR2V GO:0046872 3/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SJ7V7 GO:0006629 32/50 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8SJ7V7 GO:0005576 31/50 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8SJ7V7 GO:0016787 24/50 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8SJ7V7 GO:0003824 8/50 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SJ7V7 GO:0032504 1/50 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8SJ7V7 GO:0005615 1/50 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8XKXPG GO:0004252 1/6 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8XKXPG GO:0005886 1/6 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QZB0V GO:0031418 1/138 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8QZB0V GO:0005506 1/138 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8QZB0V GO:0016705 1/138 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8SJ7TV GO:0008239 20/129 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8SJ7TV GO:0005737 19/129 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SJ7TV GO:0016020 2/129 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8SJ7TV GO:0006508 1/129 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8SJ7TV GO:0005886 1/129 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8SJ7TV GO:0008237 1/129 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8SJ7TV GO:0046872 1/129 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SJ7TV GO:0005272 1/129 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8SJ7TV GO:0003887 1/129 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8SJ7TV GO:0016021 1/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SJ7TV GO:0004177 1/129 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8SJ7TV GO:0003677 1/129 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SJ7TV GO:0005829 1/129 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG81ZHSH GO:0008233 46/128 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG81ZHSH GO:0016740 3/128 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81ZHSH GO:0016603 3/128 glutaminyl-peptide cyclotransferase activity molecular_function "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] EOG81ZHSH GO:0046872 2/128 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81ZHSH GO:0017186 2/128 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase biological_process "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] EOG81ZHSH GO:0005576 2/128 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81ZHSH GO:0004222 1/128 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG81ZHSH GO:0005615 1/128 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG81ZHSH GO:0006508 1/128 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG81ZHSH GO:0032504 1/128 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG81ZHSH GO:0050829 1/128 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG81ZHSH GO:0005739 1/128 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8XKXPH GO:0016020 142/797 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XKXPH GO:0005515 4/797 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XKXPH GO:0015031 1/797 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8XKXPH GO:0046331 1/797 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XKXPH GO:0005789 1/797 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8XKXPH GO:0016021 1/797 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2DM GO:0005634 13/65 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2DM GO:0003700 13/65 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8XH2DM GO:0043565 10/65 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8XH2DM GO:0000976 3/65 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8XH2DM GO:0042981 1/65 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8QRKJV GO:0071011 1/82 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8QRKJV GO:0000398 1/82 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8XH2DP GO:0005524 2/22 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XH2DP GO:0003824 1/22 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8PRW52 GO:0005089 16/67 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8PRW52 GO:0035556 11/67 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8PRW52 GO:0005524 4/67 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PRW52 GO:0004674 2/67 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PRW52 GO:0004713 1/67 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8PRW52 GO:0004672 1/67 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8PRW52 GO:0004683 1/67 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8QRKJ8 GO:0008270 29/198 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QRKJ8 GO:0005634 28/198 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QRKJ8 GO:0003676 28/198 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QRKJ8 GO:0046872 4/198 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8577MX GO:0016021 75/289 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8577MX GO:0006486 74/289 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8577MX GO:0005794 73/289 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8577MX GO:0046872 72/289 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8577MX GO:0016757 70/289 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8577MX GO:0004653 9/289 polypeptide N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] EOG8577MX GO:0000139 3/289 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8577MX GO:0005795 2/289 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8577MX GO:0009312 2/289 oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] EOG8577MX GO:0006493 1/289 protein O-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] EOG8577MX GO:0033628 1/289 regulation of cell adhesion mediated by integrin biological_process "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] EOG8577MX GO:0070278 1/289 extracellular matrix constituent secretion biological_process "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] EOG8577MX GO:0031589 1/289 cell-substrate adhesion biological_process "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] EOG8577MX GO:0032504 1/289 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8577MX GO:0008376 1/289 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG8577MX GO:0016266 1/289 O-glycan processing biological_process "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] EOG8PCD6S GO:0005549 31/116 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8PCD6S GO:0004984 31/116 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8PCD6S GO:0016021 29/116 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PCD6S GO:0004930 29/116 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8PCD6S GO:0005886 20/116 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PCD6S GO:0016020 2/116 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PCD6S GO:0044267 1/116 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG8PCD6S GO:0005524 1/116 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QRKJ0 GO:0008270 49/217 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QRKJ0 GO:0016740 1/217 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8PRW5M GO:0005089 1/26 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8PRW5M GO:0046872 1/26 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PRW5M GO:0035556 1/26 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8MPM42 GO:0045944 1/82 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8MPM42 GO:0007099 1/82 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG8MPM42 GO:0044545 1/82 NSL complex cellular_component "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] EOG8MPM42 GO:0022008 1/82 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MPM42 GO:0007095 1/82 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8MPM42 GO:0005634 1/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2D2 GO:0005524 24/86 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XH2D2 GO:0017111 21/86 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8XH2D2 GO:0008568 2/86 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8XH2D2 GO:0016887 1/86 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8XH2D4 GO:0007267 2/21 cell-cell signaling biological_process "Any process that mediates the transfer of information from one cell to another." [GOC:mah] EOG8T4GB7 GO:0006457 29/94 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8T4GB7 GO:0003755 29/94 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8T4GB7 GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8T4GB7 GO:0000413 1/94 protein peptidyl-prolyl isomerization biological_process "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] EOG8T4GB7 GO:0007173 1/94 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8577MC GO:0008236 1/13 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8577MC GO:0004180 1/13 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8C5G07 GO:0004252 2199/5565 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0006508 98/5565 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8C5G07 GO:0005615 18/5565 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8C5G07 GO:0005576 17/5565 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8C5G07 GO:0007586 11/5565 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8C5G07 GO:0004175 8/5565 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8C5G07 GO:0016021 6/5565 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C5G07 GO:0016787 5/5565 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C5G07 GO:0016301 5/5565 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8C5G07 GO:0008236 5/5565 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0045087 4/5565 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8C5G07 GO:0006629 4/5565 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8C5G07 GO:0006952 3/5565 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8C5G07 GO:0045752 3/5565 positive regulation of Toll signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0050830 3/5565 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0008063 3/5565 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8C5G07 GO:0008233 3/5565 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8C5G07 GO:0005829 3/5565 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8C5G07 GO:0008889 3/5565 glycerophosphodiester phosphodiesterase activity molecular_function "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] EOG8C5G07 GO:0006071 3/5565 glycerol metabolic process biological_process "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] EOG8C5G07 GO:0050832 3/5565 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0022008 2/5565 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C5G07 GO:0050829 2/5565 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0009950 2/5565 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8C5G07 GO:0035006 2/5565 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8C5G07 GO:0007311 2/5565 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8C5G07 GO:0031638 2/5565 zymogen activation biological_process "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] EOG8C5G07 GO:0008270 1/5565 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C5G07 GO:0006964 1/5565 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8C5G07 GO:0005515 1/5565 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8C5G07 GO:0005622 1/5565 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8C5G07 GO:0004435 1/5565 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8C5G07 GO:0048812 1/5565 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8C5G07 GO:0008592 1/5565 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0006967 1/5565 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8C5G07 GO:0003964 1/5565 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8C5G07 GO:0035008 1/5565 positive regulation of melanization defense response biological_process "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035007 1/5565 regulation of melanization defense response biological_process "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035556 1/5565 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8C5G07 GO:0003723 1/5565 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8C5G07 GO:0005581 1/5565 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8C5G07 GO:0004930 1/5565 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8C5G07 GO:0006909 1/5565 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8C5G07 GO:0004180 1/5565 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8C5G07 GO:0006959 1/5565 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8C5G07 GO:0004471 1/5565 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] EOG8C5G07 GO:0016485 1/5565 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8C5G07 GO:0003677 1/5565 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C5G07 GO:0051287 1/5565 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8C5G07 GO:0042060 1/5565 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8C5G03 GO:0003779 2/344 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8C5G03 GO:0006936 1/344 muscle contraction biological_process "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] EOG8C5G03 GO:0051015 1/344 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG8C5G03 GO:0048477 1/344 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8C5G03 GO:0007507 1/344 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8C5G03 GO:0030017 1/344 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8C5G03 GO:0010591 1/344 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8C5G03 GO:0070865 1/344 investment cone cellular_component "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] EOG8C5G03 GO:0045451 1/344 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8C5G03 GO:0007315 1/344 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8C5G03 GO:0048813 1/344 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8S4RZ0 GO:0016021 116/397 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RZ0 GO:0005215 113/397 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8S4RZ0 GO:0055085 6/397 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8S4RZ0 GO:0015267 5/397 channel activity molecular_function "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] EOG8S4RZ0 GO:0003014 3/397 renal system process biological_process "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] EOG8S4RZ0 GO:0016020 3/397 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RZ0 GO:0015250 1/397 water channel activity molecular_function "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] EOG8S4RZ0 GO:0046662 1/397 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG8S4RZ0 GO:0006833 1/397 water transport biological_process "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8S4RZ0 GO:0030104 1/397 water homeostasis biological_process "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] EOG8S4RZ2 GO:0003746 2/49 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8QNQCZ GO:0016607 14/50 nuclear speck cellular_component "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] EOG8QNQCZ GO:0045944 14/50 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8QNQCZ GO:0007219 14/50 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8QNQCZ GO:0003713 14/50 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8B2WC5 GO:0016301 3/89 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8B2WC5 GO:0006915 2/89 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8B2WC5 GO:0051124 1/89 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8B2WC5 GO:0031932 1/89 TORC2 complex cellular_component "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787] EOG8B2WC5 GO:0048813 1/89 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8B2WC5 GO:0005829 1/89 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8B2WC5 GO:0003676 1/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B2WC5 GO:0001932 1/89 regulation of protein phosphorylation biological_process "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] EOG8QNQCJ GO:0016758 26/75 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8QNQCJ GO:0030246 26/75 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8QNQCJ GO:0030259 26/75 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG8KWN6J GO:0008233 14/79 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8QNQCC GO:0016021 1/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QNQCC GO:0015171 1/3 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG87M4CW GO:0008270 37/166 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87M4CW GO:0016491 33/166 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG87M4CW GO:0003960 3/166 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG87M4CW GO:0047522 1/166 15-oxoprostaglandin 13-oxidase activity molecular_function "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] EOG87M4CW GO:0036132 1/166 13-prostaglandin reductase activity molecular_function "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869] EOG87M4CZ GO:0050909 1/5 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG87M4CZ GO:0016021 1/5 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87M4CZ GO:0005886 1/5 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG83N9WH GO:0003677 1/68 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XWJCG GO:0005525 86/367 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8XWJCG GO:0006184 86/367 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8XWJCG GO:0016020 86/367 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XWJCG GO:0007264 81/367 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8XWJCG GO:0007165 5/367 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8XWJCG GO:0005622 1/367 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8XWJCG GO:0004767 1/367 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8XWJCG GO:0006909 1/367 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG87M4C7 GO:0008440 27/89 inositol-1,4,5-trisphosphate 3-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023] EOG87M4C7 GO:0005737 1/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87M4C7 GO:0006979 1/89 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8FFGG4 GO:0005524 1/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FFGG4 GO:0006183 1/14 GTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8FFGG4 GO:0003676 1/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FFGG4 GO:0006241 1/14 CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG8FFGG4 GO:0004550 1/14 nucleoside diphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] EOG8FFGG4 GO:0046872 1/14 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FFGG4 GO:0006228 1/14 UTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] EOG87M4C0 GO:0003677 12/39 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88SK7C GO:0005085 23/53 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG88SK7C GO:0007264 23/53 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG88SK7C GO:0005622 23/53 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG88SK7M GO:0016021 28/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88SK7H GO:0006749 99/277 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG88SK7H GO:0003840 99/277 gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] EOG88SK7H GO:0003810 1/277 protein-glutamine gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] EOG88SK7H GO:0032504 1/277 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG88SK7H GO:0048812 1/277 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG88SK7H GO:0005615 1/277 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8B2WCC GO:0020037 1/8 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8B2WCC GO:0016705 1/8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8B2WCC GO:0005506 1/8 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8B2WCC GO:0004497 1/8 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8QNQC4 GO:0006811 2/32 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8QNQC4 GO:0005921 2/32 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG8QNQC4 GO:0016021 1/32 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QVFSM GO:0004930 4/25 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8QVFSM GO:0016021 4/25 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QVFSM GO:0004984 4/25 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8QVFSM GO:0005886 4/25 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QVFSM GO:0005549 4/25 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8HHRHG GO:0016021 111/321 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HHRHG GO:0055085 111/321 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8HHRHG GO:0008260 2/321 3-oxoacid CoA-transferase activity molecular_function "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] EOG8HHRHG GO:0005886 1/321 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HHRHG GO:0005215 1/321 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8HHRHG GO:0006171 1/321 cAMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] EOG8HHRHG GO:0004016 1/321 adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] EOG80GG71 GO:0003676 20/947 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG71 GO:0008270 20/947 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80GG71 GO:0003677 3/947 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80GG71 GO:0005634 3/947 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80GG71 GO:0004190 2/947 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG80GG71 GO:0003964 2/947 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG80GG71 GO:0003723 2/947 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG80GG71 GO:0000786 1/947 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG80GG71 GO:0015074 1/947 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80GG71 GO:0004812 1/947 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG80GG71 GO:0006334 1/947 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8GQSMF GO:0008270 22/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSMF GO:0016740 1/97 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8VMHVF GO:0009116 27/102 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8VMHVF GO:0004731 27/102 purine-nucleoside phosphorylase activity molecular_function "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] EOG8HDWBM GO:0030246 1/19 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8F20J7 GO:0004252 15/61 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG869T9G GO:0005524 6/26 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG869T9G GO:0004672 6/26 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG869T9G GO:0004579 1/26 dolichyl-diphosphooligosaccharide-protein glycotransferase activity molecular_function "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] EOG8GQSMS GO:0008270 4/247 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSMS GO:0009631 1/247 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG883GM7 GO:0008137 27/76 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG883GM7 GO:0005739 22/76 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG883GM7 GO:0006120 5/76 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG883GM7 GO:0005747 5/76 mitochondrial respiratory chain complex I cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] EOG883GM6 GO:0000166 27/120 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG883GM6 GO:0003676 20/120 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GM6 GO:0022008 1/120 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG883GM6 GO:0030182 1/120 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG883GM6 GO:0003729 1/120 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG883GM6 GO:0005634 1/120 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTK0X GO:0004252 2/8 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8S4S1H GO:0008081 1/2 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG8S4S1H GO:0005634 1/2 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S4S1H GO:0006281 1/2 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8TTK0F GO:0004950 1/14 chemokine receptor activity molecular_function "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] EOG8TTK0F GO:0006935 1/14 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG8TTK0F GO:0016021 1/14 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV3B GO:0004252 3/7 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG883GMT GO:0005634 62/209 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG883GMT GO:0043565 61/209 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG883GMT GO:0003700 60/209 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG883GMT GO:0006366 3/209 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG883GMT GO:0045317 3/209 equator specification biological_process "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] EOG883GMT GO:0001745 3/209 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG883GMT GO:0042693 2/209 muscle cell fate commitment biological_process "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators] EOG883GMT GO:0007474 2/209 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG883GMT GO:0006355 2/209 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG883GMT GO:0003705 2/209 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG883GMT GO:0045893 2/209 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG883GMT GO:0003677 2/209 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG883GMT GO:0045944 2/209 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG883GMT GO:0007476 2/209 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG883GMT GO:0000981 1/209 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG883GMT GO:0006909 1/209 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG883GMT GO:0001700 1/209 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG883GMT GO:0000122 1/209 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG883GMT GO:0035310 1/209 notum cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] EOG883GMT GO:0048813 1/209 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG883GMT GO:0007422 1/209 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG883GMT GO:0042803 1/209 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG883GMT GO:0007224 1/209 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG883GMT GO:0046843 1/209 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG883GMT GO:0097374 1/209 sensory neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr] EOG8QJV3F GO:0004252 41/104 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8QJV3F GO:0006508 3/104 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8TTK03 GO:0005549 21/96 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8TTK03 GO:0004984 21/96 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8TTK03 GO:0004930 17/96 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8TTK03 GO:0016021 17/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TTK03 GO:0005886 8/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TTK03 GO:0016020 4/96 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z38WG GO:0015074 1/84 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8Z38WG GO:0003676 1/84 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG7T GO:0000166 14/31 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG80GG7T GO:0030366 14/31 molybdopterin synthase activity molecular_function "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] EOG80GG7T GO:0019008 14/31 molybdopterin synthase complex cellular_component "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] EOG80GG7T GO:0006777 14/31 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG80GG7T GO:0005829 14/31 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG80GG7T GO:0016573 1/31 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG80GG7T GO:0005671 1/31 Ada2/Gcn5/Ada3 transcription activator complex cellular_component "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] EOG80GG7T GO:0006338 1/31 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG80GG7T GO:0005700 1/31 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG80GG7V GO:0015031 18/54 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG80GG7V GO:0046872 18/54 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80GG7V GO:0005739 17/54 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80GG7V GO:0005743 1/54 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG80GG7V GO:0071456 1/54 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8F20JW GO:0016021 38/62 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20JW GO:0006810 36/62 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8F20JW GO:0048193 2/62 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG8F20JW GO:0005215 2/62 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8F20JW GO:0005783 1/62 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8F20JW GO:0000003 1/62 reproduction biological_process "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] EOG8F20JW GO:0061357 1/62 positive regulation of Wnt protein secretion biological_process "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] EOG8F20JW GO:0090263 1/62 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG8F20JW GO:0048042 1/62 regulation of post-mating oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766] EOG8F20JW GO:0022008 1/62 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8GQSM4 GO:0004252 19/72 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GQSM4 GO:0003824 1/72 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8GQSM4 GO:0016787 1/72 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8GQSM4 GO:0006508 1/72 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8SBHFB GO:0005761 23/78 mitochondrial ribosome cellular_component "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] EOG812PK8 GO:0005509 40/112 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG812PK8 GO:0004222 39/112 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG812PK8 GO:0008270 38/112 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG812PK8 GO:0016485 2/112 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG812PK8 GO:0008586 2/112 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG812PK8 GO:0010629 2/112 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG812PK8 GO:0030513 1/112 positive regulation of BMP signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] EOG812PK8 GO:0007378 1/112 amnioserosa formation biological_process "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238] EOG812PK8 GO:0008045 1/112 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG812PK8 GO:0008293 1/112 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG812PK8 GO:0009880 1/112 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG812PK8 GO:0007411 1/112 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG812PK8 GO:0005576 1/112 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG812PK8 GO:0016874 1/112 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG812PK8 GO:0007362 1/112 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG812PK8 GO:0006508 1/112 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG812PK8 GO:0007313 1/112 maternal specification of dorsal/ventral axis, oocyte, soma encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG812PK8 GO:0017015 1/112 regulation of transforming growth factor beta receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] EOG812PK8 GO:0007415 1/112 defasciculation of motor neuron axon biological_process "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] EOG8KPWQW GO:0018149 31/132 peptide cross-linking biological_process "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] EOG8KPWQW GO:0003810 29/132 protein-glutamine gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] EOG8KPWQW GO:0046872 22/132 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KPWQW GO:0042381 1/132 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8KPWQW GO:0045087 1/132 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG89CSR7 GO:0030529 1/79 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG89CSR7 GO:0019013 1/79 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8NCPWH GO:0000166 13/97 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NCPWH GO:0008270 13/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NCPWH GO:0003676 13/97 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPWH GO:0007303 1/97 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8NCPWH GO:0005634 1/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NCPWH GO:0045475 1/97 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8NCPWH GO:0071011 1/97 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8NCPWH GO:0008062 1/97 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG8NCPWH GO:0007067 1/97 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8NCPWH GO:0003723 1/97 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NCPWH GO:0007562 1/97 eclosion biological_process "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] EOG8NCPWH GO:0071013 1/97 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8NCPWH GO:0000398 1/97 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8NCPWH GO:0030036 1/97 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8NCPWH GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NCPWH GO:0008104 1/97 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8NCPWH GO:0045804 1/97 negative regulation of eclosion biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators] EOG8NCPWH GO:0009790 1/97 embryo development biological_process "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG8NCPWH GO:0007623 1/97 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8NCPWH GO:0003729 1/97 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG89626J GO:0003677 1/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RZ1F9 GO:0022008 1/86 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8HMMQM GO:0006909 1/103 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8HMMQM GO:0005871 1/103 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8HMMQM GO:0060632 1/103 regulation of microtubule-based movement biological_process "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] EOG8HMMQM GO:0007018 1/103 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8HMMQM GO:0045451 1/103 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG82JR67 GO:0046872 2/10 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82JR67 GO:0003677 1/10 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82JR67 GO:0003676 1/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82JR64 GO:0005634 65/228 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82JR64 GO:0006351 60/228 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82JR64 GO:0007275 58/228 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG82JR64 GO:0003700 57/228 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82JR64 GO:0043565 44/228 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82JR64 GO:0000976 11/228 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG82JR64 GO:0003677 9/228 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82JR64 GO:0006355 8/228 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82JR64 GO:0000977 3/228 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG82JR64 GO:0007367 2/228 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG82JR64 GO:0022008 2/228 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82JR64 GO:0007366 1/228 periodic partitioning by pair rule gene biological_process "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG82JR64 GO:0007435 1/228 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG82JR64 GO:0005737 1/228 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82JR64 GO:0045944 1/228 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG82JR64 GO:0007419 1/228 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG82JR64 GO:0060025 1/228 regulation of synaptic activity biological_process "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] EOG82JR64 GO:0004000 1/228 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG82JR64 GO:0006366 1/228 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG82JR64 GO:0003705 1/228 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG82JR64 GO:0007268 1/228 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8BVV7F GO:0005507 45/236 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8BVV7F GO:0016715 41/236 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG8BVV7F GO:0004500 4/236 dopamine beta-monooxygenase activity molecular_function "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120] EOG8BVV7F GO:0008345 1/236 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8BVV7F GO:0016021 1/236 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BVV7F GO:0006589 1/236 octopamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] EOG8BVV7F GO:0043059 1/236 regulation of forward locomotion biological_process "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators] EOG8BVV7F GO:0008049 1/236 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8BVV7F GO:0002121 1/236 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8BVV7F GO:0007612 1/236 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG8BVV7F GO:0040011 1/236 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8BVV7F GO:0055114 1/236 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8BVV7F GO:0030728 1/236 ovulation biological_process "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] EOG8BVV7F GO:0006355 1/236 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BVV7F GO:0048047 1/236 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8BVV7F GO:0071927 1/236 octopamine signaling pathway biological_process "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245] EOG8BVV7F GO:0003677 1/236 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BVV7F GO:0005576 1/236 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BVV7F GO:0034472 1/236 snRNA 3'-end processing biological_process "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] EOG8BVV7F GO:0007613 1/236 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG8BVV7F GO:0050795 1/236 regulation of behavior biological_process "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] EOG8BVV7F GO:0007629 1/236 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8BVV7F GO:0002118 1/236 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG8BVV7F GO:0048149 1/236 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8909Q4 GO:0005089 2/26 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8STVK9 GO:0001522 25/81 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG8STVK9 GO:0042254 25/81 ribosome biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] EOG8STVK9 GO:0005524 4/81 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8STVK9 GO:0004672 3/81 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8STVK9 GO:0006364 1/81 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8STVK9 GO:0004674 1/81 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8STVK9 GO:0005732 1/81 small nucleolar ribonucleoprotein complex cellular_component "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8STVK9 GO:0003723 1/81 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8STVK9 GO:0022008 1/81 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8STVK9 GO:0005576 1/81 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8STVK9 GO:0005634 1/81 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVK9 GO:0016772 1/81 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8DRCSQ GO:0016021 19/71 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DRCSQ GO:0005743 19/71 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8DRCSQ GO:0005509 3/71 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DRCSQ GO:0005739 1/71 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DRCSQ GO:0022008 1/71 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8STVK1 GO:0016021 23/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8STVK1 GO:0008527 22/84 taste receptor activity molecular_function "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] EOG8STVK1 GO:0005886 4/84 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8STVK1 GO:0050909 1/84 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8STVK7 GO:0008270 1/17 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8STVK7 GO:0046872 1/17 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8STVK7 GO:0003676 1/17 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8STVK7 GO:0005634 1/17 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BVV9G GO:0004535 1/69 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG8N5Z9W GO:0031011 25/90 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG8STVKM GO:0008418 27/98 protein-N-terminal asparagine amidohydrolase activity molecular_function "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481] EOG8STVKM GO:0004067 1/98 asparaginase activity molecular_function "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] EOG8BVV9J GO:0005634 48/163 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BVV9J GO:0006367 28/163 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8BVV9J GO:0030529 22/163 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8BVV9J GO:0003723 20/163 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BVV9J GO:0003743 5/163 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8BVV9J GO:0019013 4/163 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8BVV9J GO:0005669 1/163 transcription factor TFIID complex cellular_component "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] EOG8BVV9J GO:0030532 1/163 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8BVV9J GO:0008406 1/163 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8BVV9J GO:0007281 1/163 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8BVV9J GO:0000398 1/163 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8BVV9J GO:0071013 1/163 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8BVV9J GO:0007052 1/163 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8BVV9J GO:0045495 1/163 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG8BVV9J GO:0005681 1/163 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8BVV9J GO:0051123 1/163 RNA polymerase II transcriptional preinitiation complex assembly biological_process "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047] EOG8BVV9J GO:0015030 1/163 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG8BVV9J GO:0008134 1/163 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8BVV9J GO:0071011 1/163 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8BVV9J GO:0006355 1/163 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RFP9H GO:0005634 5/30 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RFP9H GO:0043565 5/30 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RFP9H GO:0003700 5/30 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8HTC6S GO:0005549 2/44 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8H48KM GO:0019843 25/70 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8H48KM GO:0006412 25/70 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8H48KM GO:0003735 25/70 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8H48KM GO:0005840 24/70 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8H48KM GO:0005762 1/70 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8H48KM GO:0006919 1/70 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8H48KM GO:0005739 1/70 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8J3ZX5 GO:0000902 18/57 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8J3ZX5 GO:0005737 17/57 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8J3ZX5 GO:0016477 1/57 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8J3ZX5 GO:0003779 1/57 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8J3ZX5 GO:0030864 1/57 cortical actin cytoskeleton cellular_component "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] EOG8J3ZX5 GO:0005874 1/57 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8J3ZX5 GO:0005886 1/57 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8J3ZX5 GO:0005923 1/57 bicellular tight junction cellular_component "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] EOG8J3ZX5 GO:0005856 1/57 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8J3ZX5 GO:0032438 1/57 melanosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] EOG8FFGGB GO:0016021 20/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGB GO:0004930 10/129 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FFGGB GO:0016499 5/129 orexin receptor activity molecular_function "Combining with orexin to initiate a change in cell activity." [GOC:ai] EOG8FFGGB GO:0007631 5/129 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8FFGGB GO:0004983 5/129 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8FFGGB GO:0004715 1/129 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8FFGGB GO:0003723 1/129 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FFGGB GO:0050254 1/129 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8FFGGB GO:0003964 1/129 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8FN6XN GO:0000166 26/99 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8FN6XN GO:0003887 26/99 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8FN6XN GO:0003677 23/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FN6XN GO:0003676 2/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FN6XN GO:0003700 1/99 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FN6XN GO:0000738 1/99 DNA catabolic process, exonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG8FN6XN GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FN6XN GO:0005875 1/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8FN6XN GO:0006261 1/99 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG8FN6XN GO:0043565 1/99 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8FN6XN GO:0008296 1/99 3'-5'-exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] EOG8FN6XN GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8FN6XN GO:0046872 1/99 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FN6XN GO:0051539 1/99 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8FN6XN GO:0043625 1/99 delta DNA polymerase complex cellular_component "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] EOG8FN6XN GO:0006974 1/99 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG82C0Q4 GO:0046872 32/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82C0Q4 GO:0003676 30/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0Q4 GO:0016458 2/102 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG82C0Q4 GO:0043565 2/102 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82C0Q4 GO:0005634 2/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82C0Q4 GO:0005515 2/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82C0Q4 GO:0003677 2/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82C0Q4 GO:0005704 1/102 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG82C0Q4 GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0006310 1/102 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG82C0Q4 GO:0010629 1/102 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG82C0Q4 GO:0031011 1/102 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG82C0Q4 GO:0006342 1/102 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG82C0Q4 GO:0048813 1/102 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG82C0Q4 GO:0045892 1/102 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0000980 1/102 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG82C0Q4 GO:0003682 1/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG82C0Q4 GO:0000790 1/102 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG82C0Q4 GO:0048096 1/102 chromatin-mediated maintenance of transcription biological_process "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] EOG82C0Q4 GO:0005703 1/102 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG82C0Q4 GO:0006281 1/102 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG82C0Q4 GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82C0Q4 GO:0006265 1/102 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG82C0Q4 GO:0031490 1/102 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG82C0Q4 GO:0005700 1/102 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8TF32N GO:0005524 2/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF32N GO:0003777 2/11 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8TF32N GO:0007018 2/11 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8TF32N GO:0005871 1/11 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8577NG GO:0004012 3/29 phospholipid-translocating ATPase activity molecular_function "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] EOG8577NG GO:0005524 3/29 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8577NG GO:0000287 3/29 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8577NG GO:0016021 3/29 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FN6XQ GO:0016491 9/70 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8FN6XQ GO:0005507 9/70 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG80041X GO:0008076 1/10 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG80041X GO:0005249 1/10 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8577N7 GO:0005097 13/64 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8X99ZV GO:0003677 1/8 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J3ZXH GO:0016772 2/16 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8QRKM7 GO:0008553 1/73 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] EOG80CKZM GO:0009107 23/135 lipoate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] EOG80CKZM GO:0016415 23/135 octanoyltransferase activity molecular_function "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] EOG80CKZM GO:0005739 22/135 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80CKZM GO:0033819 22/135 lipoyl(octanoyl) transferase activity molecular_function "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181] EOG80CKZM GO:0006464 22/135 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG80CKZM GO:0008408 18/135 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG80CKZM GO:0003676 18/135 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80CKZM GO:0005634 12/135 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80CKZM GO:0045950 12/135 negative regulation of mitotic recombination biological_process "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] EOG80CKZM GO:0046872 12/135 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80CKZM GO:0090305 11/135 nucleic acid phosphodiester bond hydrolysis biological_process "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG80CKZM GO:0016874 5/135 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG80CKZM GO:0009249 1/135 protein lipoylation biological_process "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] EOG80CKZM GO:0000738 1/135 DNA catabolic process, exonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG80CKZM GO:0005737 1/135 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80CKZM GO:0008310 1/135 single-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG80CKZM GO:0008311 1/135 double-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG8QRKM1 GO:0006412 1/39 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8QRKM1 GO:0003735 1/39 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8QRKM1 GO:0005840 1/39 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG85MQM4 GO:0046873 26/70 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG85MQM4 GO:0016020 25/70 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85MQM4 GO:0005622 1/70 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG85MQM4 GO:0003676 1/70 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85MQM4 GO:0016323 1/70 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG85MQM4 GO:0046872 1/70 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XKXQ7 GO:0004129 43/117 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8XKXQ7 GO:0005740 43/117 mitochondrial envelope cellular_component "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] EOG8XKXQ7 GO:0005811 1/117 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8B2WDB GO:0005921 5/25 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG8B2WDB GO:0006811 4/25 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG85HVFD GO:0004871 2/14 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8VDSFV GO:0046872 3/37 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZSCHP GO:0003676 128/391 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZSCHP GO:0005634 126/391 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZSCHP GO:0008270 126/391 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZSCHP GO:0046872 28/391 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZSCHP GO:0005739 24/391 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8ZSCHP GO:0003677 23/391 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZSCHP GO:0005840 3/391 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8ZSCHP GO:0007349 1/391 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8ZSCHP GO:0045143 1/391 homologous chromosome segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] EOG8ZSCHP GO:0007143 1/391 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8ZSCHP GO:0007279 1/391 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8ZSCHP GO:0006366 1/391 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8ZSCHP GO:0006357 1/391 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8ZSCHP GO:0007343 1/391 egg activation biological_process "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] EOG8ZSCHP GO:0000987 1/391 core promoter proximal region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8ZSCHP GO:0045944 1/391 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80S2WK GO:0032504 1/61 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG80S2WK GO:0007409 1/61 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG80S2WK GO:0035207 1/61 negative regulation of hemocyte proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG80S2WK GO:0005886 1/61 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80S2WK GO:0005615 1/61 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80S2WF GO:0006030 1/14 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80S2WF GO:0008061 1/14 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80S2WF GO:0005576 1/14 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CZDW8 GO:0005524 45/139 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CZDW8 GO:0008568 43/139 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8CZDW8 GO:0051013 43/139 microtubule severing biological_process "The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234] EOG8CZDW8 GO:0005813 41/139 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8CZDW8 GO:0030496 41/139 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8CZDW8 GO:0000922 41/139 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8CZDW8 GO:0005874 41/139 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8CZDW8 GO:0007126 41/139 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8CZDW8 GO:0005737 39/139 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CZDW8 GO:0008017 2/139 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8CZDW8 GO:0008352 2/139 katanin complex cellular_component "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] EOG8CZDW8 GO:0007017 2/139 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8CZDW8 GO:0017111 1/139 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8CZDW8 GO:0031252 1/139 cell leading edge cellular_component "The area of a motile cell closest to the direction of movement." [GOC:pg] EOG8CZDW8 GO:0005694 1/139 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8CZDW8 GO:0016358 1/139 dendrite development biological_process "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8CZDW8 GO:0005938 1/139 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8CZDW8 GO:0070462 1/139 plus-end specific microtubule depolymerization biological_process "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148] EOG8CZDW8 GO:0000070 1/139 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8CZDW8 GO:0022416 1/139 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8CZDW8 GO:0005875 1/139 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8CZDW8 GO:0035220 1/139 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8CZDW8 GO:0050775 1/139 positive regulation of dendrite morphogenesis biological_process "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8CZDW8 GO:0017022 1/139 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8CZDW8 GO:0007019 1/139 microtubule depolymerization biological_process "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] EOG8CZDW8 GO:0006200 1/139 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8CZDW8 GO:0031122 1/139 cytoplasmic microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] EOG8CZDW8 GO:0016322 1/139 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8CZDW8 GO:0030336 1/139 negative regulation of cell migration biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] EOG8CZDW8 GO:0008582 1/139 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG80S2WC GO:0006629 148/439 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG80S2WC GO:0005576 148/439 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80S2WC GO:0008970 88/439 phosphatidylcholine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] EOG80S2WC GO:0016787 52/439 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80S2WC GO:0052739 12/439 phosphatidylserine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034] EOG80S2WC GO:0052740 12/439 1-acyl-2-lysophosphatidylserine acylhydrolase activity molecular_function "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] EOG80S2WC GO:0004806 11/439 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG80S2WC GO:0003824 3/439 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG80S2WC GO:0003676 1/439 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80S2WC GO:0008270 1/439 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80S2WC GO:0022008 1/439 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8QZB1D GO:0016491 42/141 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8QZB1D GO:0005811 2/141 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8QZB1D GO:0008270 1/141 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QZB1D GO:0047131 1/141 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity molecular_function "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH." [EC:1.5.1.9, RHEA:24523] EOG8QZB1D GO:0035220 1/141 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8QZB1D GO:0022416 1/141 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8C5G1W GO:0006122 23/67 mitochondrial electron transport, ubiquinol to cytochrome c biological_process "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] EOG8C5G1W GO:0005750 23/67 mitochondrial respiratory chain complex III cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] EOG8C5G1W GO:0007286 1/67 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8C5G1W GO:0008121 1/67 ubiquinol-cytochrome-c reductase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] EOG8QZB1F GO:0003899 26/112 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8QZB1F GO:0006351 25/112 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8QZB1F GO:0003677 12/112 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QZB1F GO:0005875 1/112 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8QZB1F GO:0006383 1/112 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8QZB1F GO:0006360 1/112 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8QZB1T GO:0003824 11/66 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QZB1T GO:0009063 8/66 cellular amino acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] EOG8QZB1T GO:0007165 1/66 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8B2WD1 GO:0003700 1/33 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8B2WD1 GO:0007275 1/33 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8B2WD1 GO:0043565 1/33 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8B2WD1 GO:0006351 1/33 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8B2WD1 GO:0005634 1/33 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89S8NR GO:0008076 1/27 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG89S8NR GO:0005249 1/27 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8VDSF8 GO:0003676 3/73 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSF8 GO:0004526 3/73 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8VDSF8 GO:0008033 3/73 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8VDSF8 GO:0005634 3/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VDSF8 GO:0016021 1/73 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K3PBX GO:0004871 4/42 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8K3PBX GO:0004842 4/42 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8K3PBX GO:0005634 4/42 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K3PBX GO:0005509 4/42 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8K3PBX GO:0007166 4/42 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8K3PBX GO:0023051 4/42 regulation of signaling biological_process "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] EOG8QRKMQ GO:0055114 1/70 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG837TXH GO:0005576 6/76 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG837TXH GO:0008061 6/76 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0006030 6/76 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0005201 1/76 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG837TXH GO:0031012 1/76 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG837TXH GO:0005581 1/76 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8QRKMD GO:0003700 1/46 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8QRKMD GO:0043565 1/46 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85MQMP GO:0016051 25/85 carbohydrate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] EOG85MQMP GO:0016021 25/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85MQMP GO:0008146 23/85 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG85MQMP GO:0047756 2/85 chondroitin 4-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] EOG8616K8 GO:0016021 29/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616K8 GO:0055085 28/137 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8616K8 GO:0015293 1/137 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8616K8 GO:0006816 1/137 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0008273 1/137 calcium, potassium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] EOG8616K8 GO:0035725 1/137 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8616K8 GO:0006814 1/137 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0048749 1/137 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8616K8 GO:0048812 1/137 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG83N9V0 GO:0008168 22/81 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG83N9V0 GO:0016568 1/81 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG83N9V0 GO:0005730 1/81 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG83N9V0 GO:0006364 1/81 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG83N9V0 GO:0035064 1/81 methylated histone binding molecular_function "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] EOG83N9V0 GO:0006351 1/81 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG83N9V0 GO:0005677 1/81 chromatin silencing complex cellular_component "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] EOG83N9V0 GO:0000183 1/81 chromatin silencing at rDNA biological_process "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] EOG83N9V0 GO:0033553 1/81 rDNA heterochromatin cellular_component "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah] EOG8616K3 GO:0005737 26/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8616K3 GO:0016149 26/108 translation release factor activity, codon specific molecular_function "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] EOG8616K3 GO:0003747 1/108 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG8M3CPQ GO:0007165 3/23 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8M3CPP GO:0004066 31/97 asparagine synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] EOG8M3CPP GO:0070981 27/97 L-asparagine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] EOG8M3CPP GO:0005524 27/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CPP GO:0006529 4/97 asparagine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] EOG8M3CPP GO:0008152 1/97 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8NGK3Q GO:0016021 4/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NGK3Q GO:0007155 4/19 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8M3CPN GO:0008234 57/151 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8M3CPN GO:0016929 3/151 SUMO-specific protease activity molecular_function "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] EOG8M3CPN GO:0016926 3/151 protein desumoylation biological_process "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] EOG8M3CPN GO:0060997 1/151 dendritic spine morphogenesis biological_process "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] EOG8M3CPN GO:0005643 1/151 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8M3CPN GO:0006508 1/151 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8M3CPN GO:0021952 1/151 central nervous system projection neuron axonogenesis biological_process "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8M3CPN GO:0016485 1/151 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8M3CPN GO:0005637 1/151 nuclear inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] EOG8M3CPN GO:0005634 1/151 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M3CPN GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8M3CPN GO:0071456 1/151 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG87M4BS GO:0006207 2/33 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG87M4BS GO:0004070 2/33 aspartate carbamoyltransferase activity molecular_function "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016] EOG87M4BS GO:0006520 2/33 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG87M4BS GO:0016597 2/33 amino acid binding molecular_function "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] EOG87M4BS GO:0016812 1/33 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] EOG841SSX GO:0009055 1/59 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG841SSX GO:0051536 1/59 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG81RS7Z GO:0016740 46/887 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81RS7Z GO:0004364 41/887 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG81RS7Z GO:0006749 24/887 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG81RS7Z GO:0018833 4/887 DDT-dehydrochlorinase activity molecular_function "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220] EOG81RS7Z GO:0005515 2/887 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81RS7Z GO:0005576 2/887 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81RS7Z GO:0004602 2/887 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG81RS7Z GO:0009408 1/887 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG81RS7Z GO:0055114 1/887 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG81RS7Z GO:0022008 1/887 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG81RS7Z GO:0008152 1/887 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG80GG6X GO:0005615 2/61 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80GG6D GO:0006355 22/78 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG80GG6D GO:0001745 1/78 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8WWTZW GO:0004013 26/98 adenosylhomocysteinase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] EOG8WWTZW GO:0006730 26/98 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG841SSB GO:0031418 27/127 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG841SSB GO:0005506 27/127 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG841SSB GO:0016706 26/127 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG841SSB GO:0005634 10/127 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG841SSB GO:0006355 9/127 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG841SSB GO:0046872 4/127 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG841SSB GO:0031543 1/127 peptidyl-proline dioxygenase activity molecular_function "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462] EOG841SSB GO:0030307 1/127 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG841SSB GO:0019511 1/127 peptidyl-proline hydroxylation biological_process "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] EOG841SSB GO:0060439 1/127 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG841SSB GO:0001666 1/127 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG841SSB GO:0000124 1/127 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG841SSB GO:0005654 1/127 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG841SSB GO:0008104 1/127 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG841SSB GO:0007430 1/127 terminal branching, open tracheal system biological_process "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG841SSB GO:0071456 1/127 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG841SSB GO:0043970 1/127 histone H3-K9 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] EOG841SSB GO:0006974 1/127 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG841SSB GO:0006611 1/127 protein export from nucleus biological_process "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] EOG8S1WMX GO:0016772 29/143 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8QNQBR GO:0016773 6/53 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8QNQBR GO:0016798 4/53 hydrolase activity, acting on glycosyl bonds molecular_function "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] EOG8QNQBR GO:0016616 2/53 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8QNQBR GO:0006094 1/53 gluconeogenesis biological_process "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] EOG8QNQBR GO:0005524 1/53 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QNQBR GO:0005975 1/53 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8QNQBR GO:0004736 1/53 pyruvate carboxylase activity molecular_function "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847] EOG8QNQBR GO:0004075 1/53 biotin carboxylase activity molecular_function "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] EOG8QNQBR GO:0044262 1/53 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG8QNQBP GO:0005581 1/64 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8R267P GO:0015074 2/184 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8R267P GO:0003676 2/184 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R267P GO:0004190 2/184 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8R267P GO:0008157 1/184 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8R267P GO:0003723 1/184 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8R267P GO:0008270 1/184 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R267P GO:0003964 1/184 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8R267S GO:0016020 18/70 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8R267S GO:0005215 18/70 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG81NX11 GO:0003700 24/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81NX11 GO:0005667 24/88 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG81NX11 GO:0005634 24/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81NX11 GO:0004871 24/88 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG81NX11 GO:0005737 24/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81NX11 GO:0003677 24/88 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81NX11 GO:0006351 24/88 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG81NX11 GO:0046982 1/88 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG81NX11 GO:0008062 1/88 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG81NX11 GO:0007622 1/88 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG81NX11 GO:0032922 1/88 circadian regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] EOG81NX11 GO:0045475 1/88 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG81NX11 GO:0045187 1/88 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG81NX11 GO:0005515 1/88 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81NX11 GO:0048148 1/88 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG81NX11 GO:0042594 1/88 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG81NX11 GO:0000122 1/88 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG81NX11 GO:0045944 1/88 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG81NX11 GO:0007623 1/88 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG81NX11 GO:0045893 1/88 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8QNQBD GO:0004623 1/31 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG84XMX3 GO:0046872 29/119 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84XMX3 GO:0004222 24/119 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG84XMX3 GO:0003824 5/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG84XMX3 GO:0005739 1/119 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG84XMX3 GO:0031122 1/119 cytoplasmic microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] EOG84XMX3 GO:0005811 1/119 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG84XMX3 GO:0005875 1/119 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG84XMX3 GO:0008121 1/119 ubiquinol-cytochrome-c reductase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] EOG8D2953 GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D2953 GO:0004930 1/16 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG83N9VH GO:0004222 2/5 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG83N9VH GO:0008270 2/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8616KJ GO:0003676 1/15 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616KJ GO:0000166 1/15 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8616KB GO:0016757 1/70 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG83N9VC GO:0035556 3/44 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8HMMT0 GO:0008076 53/210 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8HMMT0 GO:0005249 52/210 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8HMMT0 GO:0051260 48/210 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8HMMT0 GO:0005251 2/210 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8HMMT0 GO:0004114 2/210 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG8HMMT0 GO:0030431 1/210 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8HMMT0 GO:0046872 1/210 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HMMT0 GO:0006813 1/210 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8HMMT0 GO:0005886 1/210 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TTK14 GO:0033743 30/101 peptide-methionine (R)-S-oxide reductase activity molecular_function "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24167] EOG8TTK14 GO:0006979 30/101 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8TTK14 GO:0030091 30/101 protein repair biological_process "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] EOG8TTK14 GO:0008113 2/101 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG8TTK14 GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTK14 GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TTK14 GO:0008270 1/101 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S1WQM GO:0005634 12/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WQM GO:0003700 12/62 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8S1WQB GO:0003697 24/79 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG8S1WQB GO:0006260 23/79 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8S1WQB GO:0005739 15/79 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8S1WQB GO:0020037 2/79 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8S1WQB GO:0016705 2/79 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8S1WQB GO:0005506 2/79 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8S1WQB GO:0000262 1/79 mitochondrial chromosome cellular_component "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] EOG8S1WQB GO:0006264 1/79 mitochondrial DNA replication biological_process "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] EOG8S1WQB GO:0004497 1/79 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8S1WQB GO:0000002 1/79 mitochondrial genome maintenance biological_process "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] EOG81RS9W GO:0003700 3/37 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81RS9W GO:0003677 3/37 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8323FZ GO:0042384 14/36 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8323FZ GO:0034464 14/36 BBSome cellular_component "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030] EOG82JR5H GO:0016020 86/342 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82JR5H GO:0008236 85/342 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG82JR5H GO:0006508 7/342 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG82JR5H GO:0008239 2/342 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG82JR5H GO:0016491 1/342 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG82JR5H GO:0005576 1/342 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RZ1GB GO:0008137 2/87 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8RZ1GB GO:0003954 1/87 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8HTC7D GO:0003723 26/76 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HTC7D GO:0000178 25/76 exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases." [PMID:10465791] EOG8HTC7D GO:0004527 5/76 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8HTC7D GO:0005652 1/76 nuclear lamina cellular_component "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] EOG8HTC7D GO:0000176 1/76 nuclear exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] EOG8HTC7D GO:0010468 1/76 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8HTC7D GO:0005737 1/76 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8H48JJ GO:0045177 1/82 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8H48JJ GO:0008362 1/82 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8H48JJ GO:0007424 1/82 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8H48JJ GO:0007475 1/82 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG8H48JJ GO:0040005 1/82 chitin-based cuticle attachment to epithelium biological_process "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8H48J3 GO:0005634 15/33 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8H48J3 GO:0008270 15/33 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H48J3 GO:0003676 14/33 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BK7M4 GO:0015031 26/73 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8BK7M4 GO:0042059 1/73 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8BK7M4 GO:0008593 1/73 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8BK7M4 GO:0043162 1/73 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] EOG8BK7M4 GO:0000815 1/73 ESCRT III complex cellular_component "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] EOG8KH58S GO:0005544 1/96 calcium-dependent phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] EOG8KH58S GO:0016600 1/96 flotillin complex cellular_component "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] EOG8KH58S GO:0007155 1/96 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8KH58S GO:0005198 1/96 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8KH58S GO:0035011 1/96 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8KH58S GO:0005886 1/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KH58S GO:0005509 1/96 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8V9X6G GO:0006562 1/37 proline catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8V9X6G GO:0004657 1/37 proline dehydrogenase activity molecular_function "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] EOG8TTK1P GO:0016757 2/68 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG82JR58 GO:0016747 4/28 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG82VBXX GO:0051861 22/64 glycolipid binding molecular_function "Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1] EOG82VBXX GO:0005737 22/64 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82VBXX GO:0017089 22/64 glycolipid transporter activity molecular_function "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai] EOG8K3PCT GO:0008063 2/10 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8642S7 GO:0000166 27/117 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8642S7 GO:0003676 25/117 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8642S7 GO:0003729 1/117 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8642S7 GO:0006397 1/117 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8642S7 GO:0008380 1/117 RNA splicing biological_process "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] EOG8642S7 GO:0043484 1/117 regulation of RNA splicing biological_process "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] EOG8642S7 GO:0007173 1/117 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8642S7 GO:0005634 1/117 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8642S6 GO:0005975 5/14 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8642S6 GO:0004553 5/14 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG81RS97 GO:0004402 1/77 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG81RS97 GO:0006520 1/77 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG81RS97 GO:0009058 1/77 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG81RS97 GO:0030170 1/77 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81RS97 GO:0070822 1/77 Sin3-type complex cellular_component "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] EOG81RS97 GO:0008483 1/77 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG81RS97 GO:0005634 1/77 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81RS97 GO:0005875 1/77 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8V9X6T GO:0005634 35/122 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V9X6T GO:0003700 34/122 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8V9X6T GO:0000976 23/122 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8V9X6T GO:0043565 12/122 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8V9X6T GO:0051450 2/122 myoblast proliferation biological_process "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] EOG8V9X6T GO:0007501 2/122 mesodermal cell fate specification biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] EOG8V9X6T GO:0007417 2/122 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8V9X6T GO:0007519 2/122 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG8V9X6T GO:0007507 2/122 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8V9X6T GO:0008544 2/122 epidermis development biological_process "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] EOG8V9X6T GO:0007480 2/122 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8V9X6T GO:0045664 2/122 regulation of neuron differentiation biological_process "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] EOG8V9X6T GO:0016477 2/122 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8V9X6T GO:0007483 2/122 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG8V9X6T GO:0007517 2/122 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8V9X6T GO:0042659 2/122 regulation of cell fate specification biological_process "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] EOG8V9X6T GO:0006355 2/122 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8V9X6T GO:0007520 2/122 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8V9X6T GO:0048666 1/122 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8V9X6T GO:1901739 1/122 regulation of myoblast fusion biological_process "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] EOG8V9X6T GO:0048813 1/122 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8V9X6T GO:0000122 1/122 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8V9X6T GO:0003705 1/122 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8V9X6T GO:0006366 1/122 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8BVV83 GO:0009166 125/386 nucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG8BVV83 GO:0046872 81/386 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BVV83 GO:0000166 80/386 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8BVV83 GO:0016788 75/386 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8BVV83 GO:0016787 38/386 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BVV83 GO:0008253 12/386 5'-nucleotidase activity molecular_function "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] EOG8BVV83 GO:0016311 2/386 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8BVV83 GO:0017110 1/386 nucleoside-diphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] EOG8BVV83 GO:0005524 1/386 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BVV83 GO:0017111 1/386 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8BVV83 GO:0005576 1/386 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BVV83 GO:0045134 1/386 uridine-diphosphatase activity molecular_function "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] EOG8TTK1H GO:0006457 19/41 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8TTK1H GO:0016272 19/41 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8TTK1H GO:0008796 1/41 bis(5'-nucleosyl)-tetraphosphatase activity molecular_function "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] EOG87SVX9 GO:0031012 5/52 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG87SVX9 GO:0004222 5/52 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG87SVX9 GO:0008270 5/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DJNBJ GO:0006788 22/75 heme oxidation biological_process "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] EOG8DJNBJ GO:0004392 22/75 heme oxygenase (decyclizing) activity molecular_function "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] EOG8DJNBJ GO:0042168 1/75 heme metabolic process biological_process "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653] EOG8Z0DKH GO:0008278 28/90 cohesin complex cellular_component "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095] EOG8Z0DKH GO:0007064 28/90 mitotic sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] EOG8Z0DKH GO:0003682 28/90 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8Z0DKH GO:0005524 27/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z0DKH GO:0006310 23/90 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8Z0DKH GO:0005634 23/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z0DKH GO:0006281 23/90 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8Z0DKH GO:0010629 1/90 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8Z0DKH GO:0005700 1/90 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8Z0DKH GO:0016322 1/90 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8Z0DKH GO:0048813 1/90 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8Z0DKH GO:0016319 1/90 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8Z0DKH GO:0035327 1/90 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8DJNBF GO:0005634 23/89 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DJNBF GO:0003700 23/89 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DJNBF GO:0043565 22/89 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8DJNBF GO:0007501 1/89 mesodermal cell fate specification biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] EOG8DJNBF GO:0000122 1/89 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8DJNBF GO:0000976 1/89 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8DJNBF GO:0004000 1/89 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8DJNBF GO:0007521 1/89 muscle cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] EOG8DJNBF GO:0007517 1/89 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8DNHKP GO:0008270 3/46 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z0DKS GO:0004252 7/30 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8DJNBZ GO:0003700 1/21 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DJNBZ GO:0005634 1/21 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DJNBZ GO:0043565 1/21 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82C0RB GO:0003676 26/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0RB GO:0004527 25/100 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG89627W GO:0008033 5/68 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG89627W GO:0005524 5/68 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89627W GO:0016740 1/68 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8SN449 GO:0003700 27/71 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SN449 GO:0003677 27/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SN449 GO:0005634 17/71 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN449 GO:0000390 9/71 spliceosomal complex disassembly biological_process "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] EOG8SN449 GO:0071008 9/71 U2-type post-mRNA release spliceosomal complex cellular_component "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] EOG8SN449 GO:0071011 1/71 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8SN449 GO:0071013 1/71 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8SN449 GO:0000398 1/71 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8JHFW9 GO:0009013 19/74 succinate-semialdehyde dehydrogenase [NAD(P)+] activity molecular_function "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] EOG8JHFW9 GO:0009450 17/74 gamma-aminobutyric acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] EOG8JHFW9 GO:0016620 6/74 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8JHFW9 GO:0004777 1/74 succinate-semialdehyde dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] EOG8JHFW3 GO:0016491 83/244 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8JHFW3 GO:0046592 2/244 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG8JHFW3 GO:0046872 1/244 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JHFW3 GO:0050232 1/244 putrescine oxidase activity molecular_function "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] EOG8JHFW3 GO:0005615 1/244 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JHFW3 GO:0003676 1/244 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RBT1Z GO:0030425 1/38 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8RBT1Z GO:0030178 1/38 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8RBT1Z GO:0035082 1/38 axoneme assembly biological_process "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] EOG8RBT1Z GO:0007286 1/38 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8RBT1Z GO:0007367 1/38 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8ZW7SH GO:0008270 1/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DNHK8 GO:0000155 1/71 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8DNHK8 GO:0022008 1/71 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8DNHK8 GO:0016020 1/71 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZW7SX GO:0005634 18/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZW7SX GO:0003677 18/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZW7SX GO:0007517 18/105 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8ZW7SX GO:0006355 17/105 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8ZW7SX GO:0006351 1/105 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8ZW7SX GO:0016204 1/105 determination of muscle attachment site biological_process "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] EOG8ZW7SX GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZW7SX GO:0016202 1/105 regulation of striated muscle tissue development biological_process "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] EOG8ZW7SX GO:0003700 1/105 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8ZW7SX GO:0007526 1/105 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8ZW7SX GO:0030154 1/105 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8ZW7SP GO:0006457 23/79 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8ZW7SP GO:0003755 23/79 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8ZW7SP GO:0000398 1/79 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8ZW7SP GO:0071013 1/79 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8ZW7SP GO:0071011 1/79 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG851H6J GO:0003700 8/59 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG851H6J GO:0005634 8/59 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CNT6H GO:0006511 2/15 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8CNT6C GO:0003964 574/3445 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8CNT6C GO:0003723 549/3445 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CNT6C GO:0008270 159/3445 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CNT6C GO:0003676 89/3445 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CNT6C GO:0004523 26/3445 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8CNT6C GO:0005198 8/3445 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8CNT6C GO:0005882 8/3445 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8CNT6C GO:0004519 5/3445 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8CNT6C GO:0003677 5/3445 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CNT6C GO:0046872 4/3445 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CNT6C GO:0015074 4/3445 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CNT6C GO:0016021 3/3445 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CNT6C GO:0004871 2/3445 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8CNT6C GO:0000166 1/3445 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CNT6C GO:0006310 1/3445 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8CNT6C GO:0004555 1/3445 alpha,alpha-trehalase activity molecular_function "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] EOG8CNT6C GO:0016874 1/3445 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8CNT6C GO:0005991 1/3445 trehalose metabolic process biological_process "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] EOG8CNT6C GO:0016881 1/3445 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8CNT6C GO:0016020 1/3445 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CNT6C GO:0005549 1/3445 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8CNT6C GO:0005622 1/3445 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8CNT6C GO:0005215 1/3445 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8CNT6C GO:0080019 1/3445 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8CNT6C GO:0003887 1/3445 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8CNT6C GO:0016787 1/3445 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8CNT6C GO:0022857 1/3445 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8CNT6C GO:0004984 1/3445 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8CNT6S GO:0003677 2/21 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG851H6T GO:0004252 3/63 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG851H6T GO:0005509 3/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG851H6T GO:0016021 3/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85B3X4 GO:0005576 4/40 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85B3X4 GO:0008061 4/40 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG85B3X4 GO:0006030 4/40 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG85MQNG GO:0016301 8/464 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG85MQNG GO:0005576 3/464 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85MQNG GO:0004672 1/464 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG85MQNG GO:0045297 1/464 post-mating behavior biological_process "The specific behavior of an organism following mating." [GOC:bf, GOC:pr] EOG85MQNG GO:0006468 1/464 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG85MQNG GO:0004674 1/464 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG837TWZ GO:0007267 4/48 cell-cell signaling biological_process "Any process that mediates the transfer of information from one cell to another." [GOC:mah] EOG837TWZ GO:0007275 4/48 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8THZ75 GO:0007064 1/17 mitotic sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] EOG8THZ75 GO:0008278 1/17 cohesin complex cellular_component "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095] EOG8THZ75 GO:0003682 1/17 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8C5G2Q GO:0046872 27/45 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C5G2Q GO:0055065 2/45 metal ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] EOG8C5G2Q GO:0010038 2/45 response to metal ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] EOG8C5G2Q GO:0005507 1/45 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8C5G2Q GO:0005515 1/45 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W3W2J GO:0000166 28/119 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8W3W2J GO:0003676 27/119 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W3W2J GO:0003729 1/119 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG85B3XV GO:0031083 1/80 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG85B3XV GO:0005515 1/80 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85B3XV GO:0008057 1/80 eye pigment granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] EOG8THZ7H GO:0005524 51/170 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8THZ7H GO:0005737 49/170 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8THZ7H GO:0017111 47/170 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8THZ7H GO:0030163 47/170 protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] EOG8THZ7H GO:0008233 8/170 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8THZ7H GO:0008568 3/170 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8THZ7H GO:0008540 2/170 proteasome regulatory particle, base subcomplex cellular_component "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] EOG8THZ7H GO:0005838 2/170 proteasome regulatory particle cellular_component "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] EOG8THZ7H GO:0006508 2/170 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8THZ7H GO:0043161 2/170 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG8THZ7H GO:0006974 2/170 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8THZ7H GO:0005634 1/170 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8THZ7H GO:0001673 1/170 male germ cell nucleus cellular_component "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] EOG8THZ7H GO:0042026 1/170 protein refolding biological_process "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] EOG8THZ7H GO:0000022 1/170 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8THZ7H GO:0007052 1/170 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8THZ7H GO:0008283 1/170 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8THZ7H GO:0000502 1/170 proteasome complex cellular_component "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] EOG8THZ7H GO:0009987 1/170 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8THZ7X GO:0006564 29/91 L-serine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] EOG8THZ7X GO:0004617 29/91 phosphoglycerate dehydrogenase activity molecular_function "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] EOG8THZ7X GO:0051287 28/91 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8THZ7X GO:0048037 1/91 cofactor binding molecular_function "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] EOG8THZ7S GO:0003824 23/86 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8THZ7S GO:0033608 2/86 formyl-CoA transferase activity molecular_function "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16548] EOG8THZ7S GO:0016740 1/86 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8X0Q8F GO:0016459 3/36 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8X0Q8F GO:0005524 3/36 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X0Q8F GO:0003774 3/36 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8S4RX3 GO:0046872 5/16 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S4RX3 GO:0003676 5/16 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R52HJ GO:0030246 155/416 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8R52HJ GO:0005615 3/416 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8R52HJ GO:0032504 3/416 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8R52HJ GO:0005534 3/416 galactose binding molecular_function "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732] EOG8R52HJ GO:0046692 2/416 sperm competition biological_process "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] EOG8R52HJ GO:0046008 2/416 regulation of female receptivity, post-mating biological_process "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] EOG8R52HJ GO:0008104 2/416 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8R52HJ GO:0008233 2/416 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8R52HJ GO:0016339 1/416 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG8R52HJ GO:0016787 1/416 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R52HJ GO:0009986 1/416 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8R52HJ GO:0009166 1/416 nucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG8R52HJ GO:0016020 1/416 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8R52HJ GO:0005515 1/416 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8R52HJ GO:0005576 1/416 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S4RX5 GO:0004252 53/134 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8S4RX5 GO:0005576 2/134 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S4RX5 GO:0003824 1/134 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S4RX5 GO:0006508 1/134 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8K0T2W GO:0004402 3/114 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8K0T2W GO:0005875 1/114 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8K0T2W GO:0055059 1/114 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8K0T2W GO:0061343 1/114 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG8K0T2W GO:0007015 1/114 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8K0T2W GO:0004871 1/114 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8K0T2W GO:0005886 1/114 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8K0T2W GO:0045176 1/114 apical protein localization biological_process "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] EOG80S2X2 GO:0006412 25/152 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG80S2X2 GO:0003735 25/152 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG80S2X2 GO:0015935 24/152 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG80S2X2 GO:0005763 1/152 mitochondrial small ribosomal subunit cellular_component "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] EOG80S2X2 GO:0004402 1/152 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG89KJ64 GO:0022008 1/31 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG89KJ64 GO:0046716 1/31 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG89KJ64 GO:0003677 1/31 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89KJ64 GO:0006355 1/31 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG89KJ64 GO:0035363 1/31 histone locus body cellular_component "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] EOG8S1WNX GO:0045886 1/122 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8S1WNX GO:0000932 1/122 cytoplasmic mRNA processing body cellular_component "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] EOG8S1WNX GO:0005737 1/122 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8S1WNX GO:0033962 1/122 cytoplasmic mRNA processing body assembly biological_process "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] EOG89KJ62 GO:0050909 4/15 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG89KJ62 GO:0005886 4/15 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89KJ62 GO:0016021 4/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZSCK6 GO:0005875 1/56 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG834ZMX GO:0005622 8/30 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG834ZMX GO:0005215 8/30 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8S1WNN GO:0016021 25/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S1WNN GO:0016485 25/76 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8S1WNN GO:0055037 1/76 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG8S1WNN GO:0007219 1/76 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8S1WNN GO:0045314 1/76 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG8S1WNN GO:0007010 1/76 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8S1WNN GO:0046331 1/76 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8S1WNN GO:0070765 1/76 gamma-secretase complex cellular_component "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368] EOG8S1WNN GO:0006509 1/76 membrane protein ectodomain proteolysis biological_process "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] EOG8S1WNN GO:0008594 1/76 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8S1WNN GO:0005770 1/76 late endosome cellular_component "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] EOG8S1WNN GO:0007220 1/76 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8S1WNN GO:0045463 1/76 R8 cell development biological_process "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] EOG8JDKNP GO:0006351 3/23 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8JDKNP GO:0005634 3/23 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JDKNP GO:0043565 3/23 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8JDKNP GO:0003700 3/23 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RV569 GO:0035556 24/79 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG84BDGG GO:0005524 1/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84BDGG GO:0003676 1/90 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84BDGG GO:0005703 1/90 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG84BDGG GO:0003779 1/90 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG84BDGG GO:0008026 1/90 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG84BDGG GO:0005634 1/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84BDGG GO:0006979 1/90 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG84BDGG GO:0005664 1/90 nuclear origin of replication recognition complex cellular_component "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] EOG84BDGG GO:0006260 1/90 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG812PKG GO:0005615 81/266 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG812PKG GO:0004866 81/266 endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] EOG812PKG GO:0006909 2/266 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG812PKG GO:0050830 1/266 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG812PKG GO:0032504 1/266 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG812PKG GO:0050829 1/266 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG84BDGT GO:0007155 4/21 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG84BDGT GO:0042246 4/21 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG84BDGT GO:0016021 4/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MKQXD GO:0016706 20/157 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG8MKQXD GO:0006281 15/157 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8MKQXD GO:0003677 14/157 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MKQXD GO:0005622 13/157 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MKQXD GO:0004519 12/157 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8MKQXD GO:0003906 2/157 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] EOG8MKQXD GO:0005634 1/157 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MKQXD GO:0004518 1/157 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8MKQXD GO:0090305 1/157 nucleic acid phosphodiester bond hydrolysis biological_process "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG8MKQXD GO:0006974 1/157 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8MKQXD GO:0000737 1/157 DNA catabolic process, endonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG8MKQXD GO:0046872 1/157 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MKQXD GO:0008408 1/157 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG8MKQXD GO:0008440 1/157 inositol-1,4,5-trisphosphate 3-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023] EOG8R52HZ GO:0042302 1/116 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG83JFJJ GO:0035556 82/275 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG83JFJJ GO:0016021 78/275 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83JFJJ GO:0000166 76/275 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG83JFJJ GO:0004016 72/275 adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] EOG83JFJJ GO:0009190 12/275 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG83JFJJ GO:0016849 11/275 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG83JFJJ GO:0006171 3/275 cAMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] EOG83JFJJ GO:0007611 1/275 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG83JFJJ GO:0007186 1/275 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG83JFJJ GO:0001582 1/275 detection of chemical stimulus involved in sensory perception of sweet taste biological_process "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] EOG83JFJJ GO:0046872 1/275 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83JFJJ GO:0007614 1/275 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG83JFJJ GO:0007619 1/275 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83JFJJ GO:0007617 1/275 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG83JFJJ GO:0001661 1/275 conditioned taste aversion biological_process "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] EOG83JFJJ GO:0007591 1/275 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG83JFJJ GO:0005524 1/275 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83JFJJ GO:0007612 1/275 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG83JFJJ GO:0007268 1/275 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG83JFJJ GO:0004383 1/275 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG83JFJJ GO:0008306 1/275 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG83JFJJ GO:0042302 1/275 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG83JFJJ GO:0009744 1/275 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG83JFJJ GO:0008340 1/275 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG83JFJJ GO:0016020 1/275 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83JFJJ GO:0010353 1/275 response to trehalose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] EOG83JFJJ GO:0048149 1/275 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG83JFJJ GO:0008294 1/275 calcium- and calmodulin-responsive adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] EOG83JFJJ GO:0009408 1/275 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG83JFJJ GO:0007625 1/275 grooming behavior biological_process "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] EOG83JFJJ GO:0007613 1/275 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG83JFJJ GO:0003676 1/275 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83JFJJ GO:0010738 1/275 regulation of protein kinase A signaling biological_process "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] EOG83JFJJ GO:0019933 1/275 cAMP-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG83JFJJ GO:0031000 1/275 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG83JFJJ GO:0090328 1/275 regulation of olfactory learning biological_process "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] EOG83JFJJ GO:0030431 1/275 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG83JFJJ GO:0048675 1/275 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG83JFJJ GO:0004930 1/275 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG83JFJJ GO:0008355 1/275 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG83JFJJ GO:0007274 1/275 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG83JFJJ GO:0007528 1/275 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG83JFJJ GO:0006979 1/275 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8RV56H GO:0005215 33/156 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8RV56H GO:0016021 31/156 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV56H GO:0016020 3/156 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RV56H GO:0005886 1/156 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RV56H GO:0055085 1/156 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8RV56H GO:0007399 1/156 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8RV56H GO:0006812 1/156 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8RV56H GO:0007398 1/156 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8RV56H GO:0016337 1/156 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG8RV56H GO:0007498 1/156 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8RV56H GO:0015267 1/156 channel activity molecular_function "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] EOG8RV56H GO:0031410 1/156 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8RV56H GO:0005912 1/156 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8RV56H GO:0046331 1/156 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RV56H GO:0044719 1/156 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG8RV56H GO:0030707 1/156 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8RV56H GO:0007219 1/156 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8RV56H GO:0005261 1/156 cation channel activity molecular_function "Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8RV56J GO:0004527 5/83 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8RV56J GO:0000176 1/83 nuclear exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] EOG8RV56J GO:0035327 1/83 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8RV56J GO:0010468 1/83 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8RV56J GO:0005652 1/83 nuclear lamina cellular_component "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] EOG8RV56J GO:0009022 1/83 tRNA nucleotidyltransferase activity molecular_function "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] EOG8RV56J GO:0005737 1/83 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K0T24 GO:0008270 2/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K0T24 GO:0003677 2/20 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8K0T24 GO:0005634 2/20 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JDKPV GO:0005549 46/151 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8JDKPV GO:0007606 2/151 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8JDKPV GO:0007608 2/151 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8JDKPV GO:0006810 2/151 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8JDKPV GO:0019236 2/151 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8JDKPV GO:0042048 2/151 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8JDKPV GO:0005576 2/151 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JDKPV GO:0045471 1/151 response to ethanol biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] EOG8JDKPV GO:0005550 1/151 pheromone binding molecular_function "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] EOG8JDKPV GO:0035274 1/151 diphenyl phthalate binding molecular_function "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] EOG8JDKPV GO:0035275 1/151 dibutyl phthalate binding molecular_function "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] EOG8JDKPV GO:0007619 1/151 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG869T7S GO:0004252 36/209 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG869T7S GO:0016787 1/209 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG869T7S GO:0006508 1/209 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG80GG5C GO:0046872 107/320 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80GG5C GO:0003676 107/320 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG5C GO:0016787 102/320 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80GG5C GO:0006309 4/320 apoptotic DNA fragmentation biological_process "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] EOG80GG5C GO:0005739 4/320 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80GG5C GO:0004518 4/320 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG80GG5C GO:0004519 1/320 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8TTJZ5 GO:0016021 1/33 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81NX27 GO:0016881 21/87 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG81NX27 GO:0004842 3/87 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8TTJZ3 GO:0008270 1/13 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80GG5D GO:0016491 3/12 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG893610 GO:0003700 20/51 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG893610 GO:0043565 20/51 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG893610 GO:0005634 20/51 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG893610 GO:0022008 1/51 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8M3CQ8 GO:0004402 2/84 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8K3PBS GO:0016740 5/476 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8K3PBS GO:0016021 5/476 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K3PBS GO:0003676 1/476 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K3PBS GO:0008270 1/476 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N8TKG GO:0005549 42/224 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NS5W0 GO:0007015 2/3 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8NS5W0 GO:2000601 2/3 positive regulation of Arp2/3 complex-mediated actin nucleation biological_process "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] EOG81NX2Z GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81NX2Z GO:0005328 1/6 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG81NX2H GO:0003677 2/69 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81NX2H GO:0003676 2/69 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TTJZK GO:0005509 1/17 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8SBHDH GO:0003999 26/88 adenine phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] EOG8SBHDH GO:0005737 24/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SBHDH GO:0009116 24/88 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8SBHDH GO:0006168 24/88 adenine salvage biological_process "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] EOG8SBHDH GO:0044209 2/88 AMP salvage biological_process "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350] EOG8SBHDH GO:0006166 2/88 purine ribonucleoside salvage biological_process "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] EOG8GB9P4 GO:0006334 304/573 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8GB9P4 GO:0000786 304/573 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8GB9P4 GO:0003677 304/573 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GB9P4 GO:0005634 303/573 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9P4 GO:0005515 23/573 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GB9P4 GO:0008360 2/573 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8GB9P4 GO:0007140 2/573 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8GB9P4 GO:0005700 2/573 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8GB9P4 GO:0007155 2/573 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8GB9P4 GO:0003747 1/573 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG80GG54 GO:0004970 1/22 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG80GG54 GO:0016020 1/22 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80GG54 GO:0005234 1/22 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RBT0G GO:0009072 27/84 aromatic amino acid family metabolic process biological_process "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] EOG8RBT0G GO:0003868 27/84 4-hydroxyphenylpyruvate dioxygenase activity molecular_function "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] EOG8RBT0G GO:0046872 22/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RBT0G GO:0004462 1/84 lactoylglutathione lyase activity molecular_function "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072] EOG880M9F GO:0003676 6/22 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG880M9F GO:0046872 6/22 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PK4P5 GO:0016021 1/40 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81RS89 GO:0055085 250/817 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG81RS89 GO:0005215 250/817 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG81RS89 GO:0016021 249/817 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81RS89 GO:0016020 2/817 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81RS89 GO:0006814 1/817 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG81RS89 GO:0051780 1/817 behavioral response to nutrient biological_process "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] EOG81RS89 GO:0008343 1/817 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG81RS89 GO:0016323 1/817 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG81RS89 GO:0015293 1/817 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG81RS89 GO:0007156 1/817 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG81RS89 GO:0005509 1/817 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8RZ1D6 GO:0016021 14/44 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1D6 GO:0050909 12/44 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8RZ1D6 GO:0005886 12/44 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RZ1D6 GO:0008527 2/44 taste receptor activity molecular_function "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] EOG8RZ1D8 GO:0003676 55/523 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RZ1D8 GO:0016301 3/523 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8RZ1D8 GO:0046872 2/523 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RZ1D8 GO:0005524 1/523 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RZ1D8 GO:0004743 1/523 pyruvate kinase activity molecular_function "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] EOG8RZ1D8 GO:0000287 1/523 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8RZ1D8 GO:0003723 1/523 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RZ1D8 GO:0008270 1/523 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RZ1D8 GO:0006096 1/523 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8RZ1D8 GO:0030955 1/523 potassium ion binding molecular_function "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] EOG8RZ1D8 GO:0004672 1/523 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8RZ1D8 GO:0003964 1/523 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8PK4P8 GO:0006629 27/100 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8PK4P8 GO:0005576 26/100 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PK4P8 GO:0004806 12/100 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG8PK4P8 GO:0016787 12/100 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8PK4P8 GO:0003824 3/100 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8PK4P8 GO:0007476 1/100 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG86Q982 GO:0008375 26/98 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG86Q982 GO:0030158 26/98 protein xylosyltransferase activity molecular_function "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] EOG86Q982 GO:0016020 24/98 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG86Q982 GO:0006024 24/98 glycosaminoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] EOG86Q982 GO:0042732 2/98 D-xylose metabolic process biological_process "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] EOG86Q982 GO:0030206 2/98 chondroitin sulfate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] EOG86Q982 GO:0005789 2/98 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG86Q982 GO:0000139 2/98 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG86Q982 GO:0015012 2/98 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG86Q982 GO:0016021 2/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q982 GO:0050650 2/98 chondroitin sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] EOG86Q982 GO:0016740 1/98 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG86Q981 GO:0008081 10/74 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG86Q981 GO:0003824 10/74 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG86Q981 GO:0046872 10/74 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86Q981 GO:0008168 5/74 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG86Q981 GO:0042594 1/74 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG86Q981 GO:0008893 1/74 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity molecular_function "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] EOG86Q981 GO:0016787 1/74 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG86Q981 GO:0015971 1/74 guanosine tetraphosphate catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] EOG86Q981 GO:0008728 1/74 GTP diphosphokinase activity molecular_function "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] EOG8ZW7RX GO:0016021 44/122 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZW7RX GO:0006810 39/122 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8ZW7RX GO:0055085 4/122 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8ZW7RX GO:0006310 2/122 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8ZW7RX GO:0015074 2/122 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8ZW7RX GO:0003677 2/122 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZW7RX GO:0035435 1/122 phosphate ion transmembrane transport biological_process "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] EOG8ZW7RX GO:0015114 1/122 phosphate ion transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] EOG8ZW7RX GO:0005811 1/122 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8ZW7RX GO:0048190 1/122 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8ZW7RX GO:0006817 1/122 phosphate ion transport biological_process "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8ZW7RX GO:0005743 1/122 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8ZW7RP GO:0005634 37/138 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZW7RP GO:0003684 37/138 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8ZW7RP GO:0006289 37/138 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8RZ1DR GO:0016021 64/210 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DR GO:0004930 63/210 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8RZ1DR GO:0007218 4/210 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8RZ1DR GO:0007186 3/210 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8RZ1DR GO:0008188 3/210 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8RZ1DR GO:0007193 2/210 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8RZ1DR GO:0008344 2/210 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8RZ1DR GO:0035013 2/210 myosuppressin receptor activity molecular_function "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] EOG8RZ1DR GO:0005887 2/210 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DR GO:0002209 1/210 behavioral defense response biological_process "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8RZ1DR GO:0008345 1/210 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8RZ1DX GO:0006633 132/423 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RZ1DX GO:0016021 132/423 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DX GO:0016717 92/423 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG8RZ1DX GO:0004768 40/423 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG8RZ1DX GO:0005783 36/423 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8RZ1DX GO:0005506 35/423 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8RZ1DX GO:0060179 1/423 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8RZ1DX GO:0042811 1/423 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0004984 1/423 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8RZ1DX GO:0010506 1/423 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8RZ1DX GO:0007619 1/423 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8RZ1DX GO:0005811 1/423 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8RZ1DX GO:0048047 1/423 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8RZ1DX GO:0042810 1/423 pheromone metabolic process biological_process "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0042593 1/423 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG8RZ1DX GO:0070328 1/423 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8RZ1DX GO:0000281 1/423 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8RZ1DX GO:0006909 1/423 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8RZ1DX GO:0031410 1/423 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8RZ1DX GO:0019216 1/423 regulation of lipid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] EOG8RZ1DX GO:0005549 1/423 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8RZ1DX GO:0009744 1/423 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8RZ1DX GO:0006723 1/423 cuticle hydrocarbon biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] EOG86Q98W GO:0005840 1/8 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8PK4PD GO:0005524 81/297 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PK4PD GO:0004674 77/297 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PK4PD GO:0006468 5/297 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8PK4PD GO:0004683 4/297 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8PK4PD GO:0042594 2/297 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8PK4PD GO:0004672 2/297 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8PK4PD GO:0045169 1/297 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8PK4PD GO:0007015 1/297 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8PK4PD GO:0031594 1/297 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8PK4PD GO:0009798 1/297 axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] EOG8PK4PD GO:0055088 1/297 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8PK4PD GO:0061174 1/297 type I terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] EOG8PK4PD GO:0007317 1/297 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8PK4PD GO:0019730 1/297 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8PK4PD GO:0007318 1/297 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8PK4PD GO:0008360 1/297 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PK4PD GO:0000226 1/297 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8PK4PD GO:0030111 1/297 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8PK4PD GO:0007294 1/297 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8PK4PD GO:0007298 1/297 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PK4PD GO:0001737 1/297 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8PK4PD GO:0005938 1/297 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8PK4PD GO:0090176 1/297 microtubule cytoskeleton organization involved in establishment of planar polarity biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8PK4PD GO:0030709 1/297 border follicle cell delamination biological_process "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] EOG8PK4PD GO:0016323 1/297 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8PK4PD GO:0009994 1/297 oocyte differentiation biological_process "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] EOG8PK4PD GO:0051663 1/297 oocyte nucleus localization involved in oocyte dorsal/ventral axis specification biological_process "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8PK4PD GO:0045451 1/297 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8PK4PD GO:0045172 1/297 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8PK4PD GO:0050321 1/297 tau-protein kinase activity molecular_function "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] EOG8PK4PD GO:0007314 1/297 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8PK4PD GO:0009948 1/297 anterior/posterior axis specification biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PK4PD GO:0045185 1/297 maintenance of protein location biological_process "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] EOG8PK4PD GO:0030707 1/297 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PK4PD GO:0051124 1/297 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8PK4PD GO:0016325 1/297 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG81RS8C GO:0020037 56/125 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG81RS8C GO:0005506 56/125 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG81RS8C GO:0016705 53/125 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG81RS8C GO:0004497 47/125 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG81RS8C GO:0070330 2/125 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG81RS8C GO:0007552 1/125 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG81RS8C GO:0035210 1/125 prepupal development biological_process "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm] EOG81RS8C GO:0007304 1/125 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG81RS8C GO:0005789 1/125 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG81RS8C GO:0016712 1/125 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG81RS8C GO:0007480 1/125 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG81RS8C GO:0035074 1/125 pupation biological_process "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] EOG81RS8C GO:0008395 1/125 steroid hydroxylase activity molecular_function "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544] EOG81RS8C GO:0046344 1/125 ecdysteroid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] EOG81RS8C GO:0016021 1/125 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZW7R0 GO:0007165 29/97 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8ZW7R0 GO:0005622 29/97 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8ZW7R0 GO:0005096 6/97 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8ZW7R0 GO:0007480 1/97 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8ZW7R0 GO:0005543 1/97 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8ZW7R1 GO:0003824 7/38 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8ZW7R1 GO:0005975 7/38 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8RZ1DM GO:0016772 18/78 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Q87FD GO:0055114 2/35 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8N333S GO:0030837 26/94 negative regulation of actin filament polymerization biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] EOG8N333S GO:0005622 22/94 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8N333S GO:0005856 4/94 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8N333S GO:0005938 4/94 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8N333S GO:0005737 2/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8N333S GO:0030833 2/94 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8N333S GO:0003779 2/94 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8N333S GO:0005886 2/94 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8N333S GO:0007298 1/94 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8N333S GO:0008407 1/94 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8N333S GO:0010591 1/94 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8N333S GO:0030042 1/94 actin filament depolymerization biological_process "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] EOG8N333S GO:0007274 1/94 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8N333S GO:0016319 1/94 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8N333S GO:0016301 1/94 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8N333S GO:0048488 1/94 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8ZPHBF GO:0004672 2/20 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8ZPHBF GO:0005524 2/20 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPHBF GO:0016772 1/20 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8RNDQC GO:0016021 30/176 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RNDQC GO:0006633 28/176 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RNDQC GO:0016740 28/176 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8RNDQC GO:0016491 26/176 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8RNDQC GO:0009922 2/176 fatty acid elongase activity molecular_function "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] EOG8RNDQC GO:0030497 2/176 fatty acid elongation biological_process "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] EOG8RNDQC GO:0070524 2/176 11-beta-hydroxysteroid dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] EOG8RNDQC GO:0042759 1/176 long-chain fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators] EOG8RNDQC GO:0042811 1/176 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RNDQC GO:0018454 1/176 acetoacetyl-CoA reductase activity molecular_function "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] EOG8RNDQC GO:0019368 1/176 fatty acid elongation, unsaturated fatty acid biological_process "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] EOG8RNDQC GO:0004316 1/176 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8RNDQB GO:0003684 24/88 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8RNDQB GO:0006289 24/88 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8RNDQB GO:0008534 24/88 oxidized purine nucleobase lesion DNA N-glycosylase activity molecular_function "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] EOG8RNDQB GO:0006284 23/88 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8RNDQB GO:0006974 1/88 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8RNDQB GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RNDQB GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8G7FDF GO:0003729 28/101 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8G7FDF GO:0005849 28/101 mRNA cleavage factor complex cellular_component "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] EOG8G7FDF GO:0006378 28/101 mRNA polyadenylation biological_process "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] EOG8G7FDF GO:0016787 24/101 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8G7FDF GO:0006379 1/101 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG8X99X5 GO:0005622 2/114 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8X99X5 GO:0008270 2/114 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X99X5 GO:0035194 1/114 posttranscriptional gene silencing by RNA biological_process "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283] EOG8X99X5 GO:0005634 1/114 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X99X5 GO:0043186 1/114 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8BP3TD GO:0046872 25/89 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BP3TD GO:0004462 25/89 lactoylglutathione lyase activity molecular_function "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072] EOG8G1PX5 GO:0016301 40/136 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8G1PX5 GO:0005524 36/136 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G1PX5 GO:0004054 3/136 arginine kinase activity molecular_function "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22943] EOG8G1PX5 GO:0016310 1/136 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8G1PX5 GO:0005576 1/136 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TF30P GO:0005524 74/266 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF30P GO:0016021 72/266 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TF30P GO:0005024 59/266 transforming growth factor beta-activated receptor activity molecular_function "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] EOG8TF30P GO:0004702 9/266 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8TF30P GO:0004675 9/266 transmembrane receptor protein serine/threonine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30] EOG8TF30P GO:0004672 3/266 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8TF30P GO:0007179 3/266 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8TF30P GO:0006468 3/266 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8TF30P GO:0004674 3/266 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8TF30P GO:0007476 3/266 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8TF30P GO:0005025 3/266 transforming growth factor beta receptor activity, type I molecular_function "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:REACT_6945.1] EOG8TF30P GO:0042078 2/266 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG8TF30P GO:0007448 2/266 anterior/posterior pattern specification, imaginal disc biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] EOG8TF30P GO:0008101 2/266 decapentaplegic signaling pathway biological_process "A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827] EOG8TF30P GO:0045887 2/266 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8TF30P GO:0030707 2/266 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8TF30P GO:0007304 2/266 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8TF30P GO:0009953 2/266 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8TF30P GO:0030509 2/266 BMP signaling pathway biological_process "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034] EOG8TF30P GO:0005515 2/266 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TF30P GO:0001745 2/266 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8TF30P GO:0030718 2/266 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8TF30P GO:0005886 2/266 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TF30P GO:0010862 1/266 positive regulation of pathway-restricted SMAD protein phosphorylation biological_process "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] EOG8TF30P GO:0050431 1/266 transforming growth factor beta binding molecular_function "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732] EOG8TF30P GO:0045824 1/266 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8TF30P GO:0045705 1/266 negative regulation of salivary gland boundary specification biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] EOG8TF30P GO:0007488 1/266 histoblast morphogenesis biological_process "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] EOG8TF30P GO:0007391 1/266 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8TF30P GO:0030514 1/266 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8TF30P GO:0008358 1/266 maternal determination of anterior/posterior axis, embryo biological_process "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8TF30P GO:0001763 1/266 morphogenesis of a branching structure biological_process "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] EOG8TF30P GO:0007165 1/266 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8TF30P GO:0035215 1/266 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8TF30P GO:0016361 1/266 activin receptor activity, type I molecular_function "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] EOG8TF30P GO:0048179 1/266 activin receptor complex cellular_component "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651] EOG8TF30P GO:0040018 1/266 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8TF30P GO:0030513 1/266 positive regulation of BMP signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] EOG8TF30P GO:0045927 1/266 positive regulation of growth biological_process "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG8TF30P GO:0007346 1/266 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8TF30P GO:0008582 1/266 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8TF30P GO:0030512 1/266 negative regulation of transforming growth factor beta receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] EOG8TF30P GO:0007181 1/266 transforming growth factor beta receptor complex assembly biological_process "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway] EOG8TF30P GO:0010629 1/266 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8TF30P GO:0005887 1/266 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TF30P GO:0046845 1/266 branched duct epithelial cell fate determination, open tracheal system biological_process "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] EOG8TF30P GO:0007455 1/266 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8TF30P GO:0007411 1/266 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8TF30P GO:0048666 1/266 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8TF30P GO:0004703 1/266 G-protein coupled receptor kinase activity molecular_function "Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate." [GOC:dph] EOG8TF30P GO:0048185 1/266 activin binding molecular_function "Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah] EOG8TF30P GO:0007300 1/266 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8TF30P GO:0032924 1/266 activin receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] EOG8TF30P GO:0007015 1/266 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8TF30P GO:0050829 1/266 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8TF30P GO:0048477 1/266 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8TF30P GO:0061327 1/266 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8TF30P GO:0009411 1/266 response to UV biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] EOG8TF30P GO:0048813 1/266 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8TF30P GO:0007274 1/266 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8TF30P GO:0090254 1/266 cell elongation involved in imaginal disc-derived wing morphogenesis biological_process "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8TF30P GO:0007507 1/266 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8TF30P GO:0007424 1/266 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8TF30P GO:0005769 1/266 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8TF30P GO:0048636 1/266 positive regulation of muscle organ development biological_process "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] EOG8TF30P GO:0035222 1/266 wing disc pattern formation biological_process "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] EOG8TF30P GO:0005771 1/266 multivesicular body cellular_component "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] EOG8TF30P GO:0022407 1/266 regulation of cell-cell adhesion biological_process "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] EOG8TF30P GO:0006357 1/266 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8TF30P GO:0048100 1/266 wing disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] EOG8TF30P GO:0045570 1/266 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG8TF30P GO:0016319 1/266 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8TF30P GO:0016477 1/266 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8TF30P GO:0045595 1/266 regulation of cell differentiation biological_process "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] EOG8TF30P GO:0007405 1/266 neuroblast proliferation biological_process "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] EOG8J9QD9 GO:0008233 12/75 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8J9QD9 GO:0004180 4/75 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8J9QD9 GO:0004177 3/75 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8J9QD9 GO:0008168 1/75 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8J9QD9 GO:0003676 1/75 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80ZTCK GO:0006814 84/227 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG80ZTCK GO:0016020 82/227 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80ZTCK GO:0055085 82/227 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG80ZTCK GO:0005215 82/227 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG80ZTCK GO:0008340 2/227 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG80ZTCK GO:0015141 2/227 succinate transmembrane transporter activity molecular_function "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732] EOG80ZTCK GO:0015744 2/227 succinate transport biological_process "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:0006848 2/227 pyruvate transport biological_process "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:0071422 2/227 succinate transmembrane transport biological_process "A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG80ZTCK GO:0005887 2/227 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80ZTCK GO:0015137 2/227 citrate transmembrane transporter activity molecular_function "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai] EOG80ZTCK GO:0015746 2/227 citrate transport biological_process "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:1901475 2/227 pyruvate transmembrane transport biological_process "The directed movement of pyruvate across a membrane." [GOC:TermGenie] EOG80ZTCK GO:0050833 2/227 pyruvate transmembrane transporter activity molecular_function "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai] EOG80ZTCK GO:0000077 1/227 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG80ZTCK GO:0016323 1/227 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG80ZTCK GO:0005886 1/227 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80ZTCK GO:0010889 1/227 regulation of sequestering of triglyceride biological_process "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] EOG80ZTCK GO:0030896 1/227 checkpoint clamp complex cellular_component "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] EOG8PZMMR GO:0017040 2/119 ceramidase activity molecular_function "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] EOG8PZMMR GO:0006665 2/119 sphingolipid metabolic process biological_process "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8PZMMR GO:0005576 2/119 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PZMMR GO:0005737 1/119 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PZMMR GO:0016079 1/119 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8PZMMR GO:0046514 1/119 ceramide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai] EOG8PZMMR GO:0031629 1/119 synaptic vesicle fusion to presynaptic membrane biological_process "Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009] EOG8PZMMR GO:0007268 1/119 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8PZMMR GO:0009415 1/119 response to water biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] EOG8PZMMR GO:0006950 1/119 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8PZMMR GO:0045494 1/119 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG8PZMMR GO:0035187 1/119 hatching behavior biological_process "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] EOG8PZMMS GO:0004077 26/86 biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] EOG8PZMMS GO:0006464 25/86 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8PZMMS GO:0009408 1/86 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8PZMMS GO:0018054 1/86 peptidyl-lysine biotinylation biological_process "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] EOG8PZMMS GO:0004080 1/86 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity molecular_function "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] EOG8PZMMS GO:0071110 1/86 histone biotinylation biological_process "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] EOG8PZMMS GO:0005700 1/86 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG80ZTCN GO:0004843 35/93 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG80ZTCN GO:0005622 34/93 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG80ZTCN GO:0006511 34/93 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG80ZTCN GO:0008242 30/93 omega peptidase activity molecular_function "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] EOG80ZTCN GO:0004221 3/93 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG80ZTCN GO:0043161 1/93 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG80ZTCN GO:0005838 1/93 proteasome regulatory particle cellular_component "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] EOG80ZTCN GO:0022008 1/93 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG80ZTCS GO:0016021 2/73 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80ZTCT GO:0016787 26/181 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80ZTCT GO:0052689 3/181 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG80ZTCT GO:0008152 1/181 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG80ZTCT GO:0005737 1/181 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PCD5T GO:0003676 1/34 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PCD5T GO:0008270 1/34 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z919S GO:0005524 27/100 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z919S GO:0004674 21/100 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8Z919S GO:0004672 5/100 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8Z919S GO:0035234 1/100 ectopic germ cell programmed cell death biological_process "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] EOG8Z919S GO:0071480 1/100 cellular response to gamma radiation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] EOG8Z919S GO:0006915 1/100 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8Z919S GO:0006468 1/100 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8Z919S GO:0000077 1/100 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG8Z919S GO:0005634 1/100 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z919S GO:0004683 1/100 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8Z919S GO:0050321 1/100 tau-protein kinase activity molecular_function "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] EOG8Z919S GO:0051091 1/100 positive regulation of sequence-specific DNA binding transcription factor activity biological_process "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] EOG8Z919S GO:0004697 1/100 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8Z919S GO:0006974 1/100 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8Z919S GO:0006919 1/100 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8Z919S GO:0045944 1/100 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Z919S GO:0072332 1/100 intrinsic apoptotic signaling pathway by p53 class mediator biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] EOG8Z919S GO:0006282 1/100 regulation of DNA repair biological_process "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] EOG8Z919S GO:0016607 1/100 nuclear speck cellular_component "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] EOG8Z919S GO:0007281 1/100 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8Z919S GO:0008630 1/100 intrinsic apoptotic signaling pathway in response to DNA damage biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG8Z919V GO:0008241 93/395 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8Z919V GO:0016020 92/395 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z919V GO:0008237 91/395 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8Z919V GO:0004180 14/395 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8Z919V GO:0005615 2/395 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z919V GO:0016491 2/395 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8Z919V GO:0006508 2/395 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8Z919V GO:0045938 1/395 positive regulation of circadian sleep/wake cycle, sleep biological_process "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] EOG8Z919V GO:0007289 1/395 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG8Z919V GO:0009609 1/395 response to symbiotic bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732] EOG8Z919V GO:0005576 1/395 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z919V GO:0046872 1/395 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Z919V GO:0004222 1/395 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8Z919V GO:0007291 1/395 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8Z919V GO:0007507 1/395 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8Z919V GO:0003700 1/395 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z919V GO:0016021 1/395 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z919V GO:0005634 1/395 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z919V GO:0005515 1/395 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8Z919V GO:0030431 1/395 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8Z919V GO:0007552 1/395 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8Z919V GO:0008270 1/395 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z919V GO:0043565 1/395 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z919Z GO:0046873 25/52 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8Z919Z GO:0016020 25/52 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DNHJQ GO:0000166 1/920 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8DNHJQ GO:0003676 1/920 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MWBNT GO:0005509 3/46 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG80ZTC6 GO:0016772 15/28 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8J9QDF GO:0004930 24/78 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8J9QDF GO:0016021 24/78 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J9QDF GO:0004984 24/78 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8J9QDF GO:0005549 24/78 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8J9QDF GO:0005886 5/78 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84N172 GO:0008270 1/48 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84N172 GO:0003964 1/48 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG84N172 GO:0003676 1/48 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84N172 GO:0003723 1/48 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8G7FD5 GO:0016021 54/201 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FD5 GO:0005242 54/201 inward rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] EOG8G7FD5 GO:0004672 2/201 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8G7FD5 GO:0042391 2/201 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8G7FD5 GO:0071805 2/201 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8G7FD5 GO:0035220 2/201 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8G7FD5 GO:0005524 2/201 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G7FD5 GO:0006813 2/201 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8G7FD5 GO:0045475 1/201 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8G7FD5 GO:0048812 1/201 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8G7FD5 GO:0090099 1/201 negative regulation of decapentaplegic signaling pathway biological_process "Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb] EOG84N174 GO:0004252 3/34 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8W3W33 GO:0003676 4/9 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W3W33 GO:0000166 4/9 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG837TV0 GO:0004252 5/25 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8W3W35 GO:0016020 22/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8W3W35 GO:0004602 1/79 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8W3W35 GO:0006979 1/79 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG83XXHD GO:0005452 24/93 inorganic anion exchanger activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] EOG83XXHD GO:0016021 24/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZSCJW GO:0003735 27/96 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8ZSCJW GO:0006412 27/96 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8ZSCJW GO:0005840 27/96 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8ZSCJW GO:0019843 3/96 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8ZSCJW GO:0000228 1/96 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8ZSCJW GO:0005730 1/96 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8ZSCJW GO:0022008 1/96 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8ZSCJW GO:0000022 1/96 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8ZSCJW GO:0007052 1/96 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8ZSCJW GO:0005737 1/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VDSDV GO:0043565 1/16 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8VDSDV GO:0006351 1/16 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8VDSDV GO:0005634 1/16 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VDSDV GO:0003700 1/16 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8VDSDV GO:0008270 1/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89KJ5B GO:0035556 19/128 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG89KJ5B GO:0046872 17/128 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GTNV0 GO:0006281 5/111 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8GTNV0 GO:0003677 5/111 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GTNV0 GO:0035220 1/111 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8GTNV0 GO:0022416 1/111 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8GTNV0 GO:0005634 1/111 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GTNV0 GO:0048749 1/111 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8JDKQV GO:0005249 6/63 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8JDKQV GO:0008076 6/63 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8B2WF9 GO:0005739 3/84 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8B2WF9 GO:0042742 1/84 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG851H5H GO:0008270 15/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CNT7B GO:0000045 25/85 autophagosome assembly biological_process "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] EOG8CNT7B GO:0005737 25/85 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CNT7B GO:0006914 1/85 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8CNT7B GO:0016236 1/85 macroautophagy biological_process "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] EOG8CNT7B GO:0035071 1/85 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8CNT7B GO:0048102 1/85 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8ZSCJ6 GO:0006869 23/125 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8ZSCJ6 GO:0033868 1/125 Goodpasture-antigen-binding protein kinase activity molecular_function "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] EOG8B2WF4 GO:0016021 1/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B2WF4 GO:0004930 1/17 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8M0HH4 GO:0030246 43/188 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8W3W3Q GO:0016021 2/10 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W3W3Q GO:0042246 2/10 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8W3W3Q GO:0007155 2/10 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG83JFK2 GO:0016772 13/83 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG83JFK2 GO:0003676 2/83 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83JFK2 GO:0046872 1/83 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8W3W3C GO:0006744 25/67 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8W3W3C GO:0031314 22/67 extrinsic component of mitochondrial inner membrane cellular_component "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] EOG8W3W3C GO:0005743 1/67 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG87M4DK GO:0003700 1/13 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG87M4DK GO:0043565 1/13 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG87M4DK GO:0005634 1/13 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87M4DC GO:0016787 24/73 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG87M4DC GO:0051726 1/73 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8QJV6H GO:0005634 2/3 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QJV6H GO:0008270 2/3 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M3CRM GO:0006030 1/386 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8M3CRM GO:0008010 1/386 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8M3CRM GO:0005578 1/386 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8M3CRM GO:0005576 1/386 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8M3CRM GO:0008061 1/386 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8M3CRM GO:0040003 1/386 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8M3CRM GO:0022008 1/386 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8B5RMD GO:0016791 1/7 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG89360G GO:0003676 70/406 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89360G GO:0005634 11/406 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89360G GO:0003700 9/406 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG89360G GO:0003707 9/406 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG89360G GO:0006351 8/406 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG89360G GO:0046872 3/406 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89360G GO:0003964 2/406 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG89360G GO:0003723 2/406 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG89360G GO:0005506 1/406 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG89360G GO:0042981 1/406 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG89360G GO:0003677 1/406 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89360G GO:0008270 1/406 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89360G GO:0019058 1/406 viral life cycle biological_process "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] EOG89360G GO:0005622 1/406 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89360G GO:0006886 1/406 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG883GJB GO:0004252 5/39 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG89360X GO:0006614 26/87 SRP-dependent cotranslational protein targeting to membrane biological_process "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] EOG89360X GO:0008312 26/87 7S RNA binding molecular_function "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] EOG89360X GO:0048500 25/87 signal recognition particle cellular_component "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] EOG89360X GO:0005786 1/87 signal recognition particle, endoplasmic reticulum targeting cellular_component "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] EOG8B5RMT GO:0003824 2/15 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8B5RMT GO:0009063 1/15 cellular amino acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] EOG89360P GO:0016021 60/147 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TQPQM GO:0042254 26/103 ribosome biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] EOG8TQPQM GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82NMDS GO:0016021 30/109 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82NMDS GO:0055085 30/109 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8N333H GO:0004252 26/45 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8N333H GO:0006508 2/45 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8N333H GO:0016787 1/45 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8N333H GO:0022008 1/45 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8N333H GO:0004175 1/45 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG886BT3 GO:0016021 44/166 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BT3 GO:0004930 37/166 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG886BT3 GO:0050254 5/166 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG886BT3 GO:0005000 4/166 vasopressin receptor activity molecular_function "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] EOG886BT3 GO:0016500 3/166 protein-hormone receptor activity molecular_function "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] EOG886BT3 GO:0055088 1/166 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG886BT3 GO:0070328 1/166 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG886BT3 GO:0016042 1/166 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG886BT3 GO:0097004 1/166 adipokinetic hormone binding molecular_function "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG886BT3 GO:0097003 1/166 adipokinetic hormone receptor activity molecular_function "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG886BT3 GO:0033500 1/166 carbohydrate homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] EOG886BT3 GO:0005887 1/166 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BT3 GO:0007218 1/166 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG886BT3 GO:0008188 1/166 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG886BT3 GO:0007186 1/166 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8B5RM4 GO:0003676 25/321 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B5RM4 GO:0005576 12/321 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8B5RM4 GO:0032504 4/321 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8B5RM4 GO:0004867 3/321 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8B5RM4 GO:0005615 3/321 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8B5RM4 GO:0008104 1/321 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8B5RM4 GO:0004386 1/321 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8B5RM4 GO:0046692 1/321 sperm competition biological_process "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] EOG8B5RM4 GO:0046008 1/321 regulation of female receptivity, post-mating biological_process "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] EOG8B5RM4 GO:0050829 1/321 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG893604 GO:0003743 27/86 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG893604 GO:0005850 27/86 eukaryotic translation initiation factor 2 complex cellular_component "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] EOG893604 GO:0006413 1/86 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG893604 GO:0005851 1/86 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG893604 GO:0000022 1/86 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG893604 GO:0005829 1/86 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG893604 GO:0007052 1/86 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG893604 GO:0005875 1/86 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG893605 GO:0006355 25/99 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG893605 GO:0006289 25/99 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG893605 GO:0000439 25/99 core TFIIH complex cellular_component "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] EOG893605 GO:0006366 1/99 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG893605 GO:0009411 1/99 response to UV biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] EOG893605 GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG893605 GO:0001113 1/99 transcriptional open complex formation at RNA polymerase II promoter biological_process "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] EOG893605 GO:0005675 1/99 holo TFIIH complex cellular_component "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] EOG893605 GO:0006367 1/99 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG893605 GO:0001111 1/99 promoter clearance from RNA polymerase II promoter biological_process "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] EOG893605 GO:0003743 1/99 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8B5RM8 GO:0016021 2/18 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B5RM8 GO:0004930 2/18 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8B5RM8 GO:0016055 2/18 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8B5RM8 GO:0007275 2/18 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8M3CR2 GO:0051726 1/67 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8M3CR2 GO:0051349 1/67 positive regulation of lyase activity biological_process "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] EOG8WSZRS GO:0004197 68/247 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WSZRS GO:0006915 68/247 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8WSZRS GO:0010623 2/247 developmental programmed cell death biological_process "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] EOG8WSZRS GO:0016322 2/247 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8WSZRS GO:0045476 2/247 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8WSZRS GO:0005737 2/247 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRS GO:0012501 2/247 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8WSZRS GO:0005515 2/247 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WSZRS GO:0046672 1/247 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WSZRS GO:0009267 1/247 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8WSZRS GO:0035103 1/247 sterol regulatory element binding protein cleavage biological_process "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525] EOG8WSZRS GO:0010165 1/247 response to X-ray biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] EOG8WSZRS GO:0007275 1/247 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8WSZRS GO:0030036 1/247 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8WSZRS GO:0048515 1/247 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8WSZRS GO:0007300 1/247 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8WSZRS GO:0048477 1/247 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8WSZRS GO:0097194 1/247 execution phase of apoptosis biological_process "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] EOG8WSZRS GO:0007015 1/247 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8WSZRS GO:0035071 1/247 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8WSZRS GO:0046668 1/247 regulation of retinal cell programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] EOG8WSZRS GO:0016239 1/247 positive regulation of macroautophagy biological_process "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] EOG8WSZRS GO:0010508 1/247 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8WSZRS GO:0035070 1/247 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8WSZRS GO:1900074 1/247 negative regulation of neuromuscular synaptic transmission biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG8WSZRS GO:0007303 1/247 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8WSZRS GO:0097200 1/247 cysteine-type endopeptidase activity involved in execution phase of apoptosis molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase] EOG8WSZRS GO:0048102 1/247 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8PZMQM GO:0005742 22/54 mitochondrial outer membrane translocase complex cellular_component "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] EOG8PZMQM GO:0030150 22/54 protein import into mitochondrial matrix biological_process "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] EOG8VQD4W GO:0015934 25/162 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG8VQD4W GO:0003735 25/162 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8VQD4W GO:0006412 25/162 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8VQD4W GO:0070403 23/162 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG8VQD4W GO:0051298 1/162 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8VQD4W GO:0046872 1/162 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VQD4W GO:0016787 1/162 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8VQD4W GO:0000022 1/162 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8VQD4W GO:0007052 1/162 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8VQD4W GO:0008340 1/162 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8PZMQG GO:0072546 24/77 ER membrane protein complex cellular_component "A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, PMID:19325107] EOG8VQD4K GO:0006807 66/157 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG8VQD4K GO:0016810 49/157 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] EOG8VQD4K GO:0000257 15/157 nitrilase activity molecular_function "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] EOG8VQD4K GO:0004328 2/157 formamidase activity molecular_function "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21951] EOG8VQD4J GO:0042246 3/15 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8VQD4J GO:0007155 3/15 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8VQD4J GO:0016021 3/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TTK3J GO:0046872 1/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TTK3J GO:0003676 1/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H1DBR GO:0005576 2/77 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8H1DBR GO:0008543 2/77 fibroblast growth factor receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] EOG8H1DBR GO:0006935 1/77 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG8H1DBR GO:0007430 1/77 terminal branching, open tracheal system biological_process "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8H1DBR GO:0046847 1/77 filopodium assembly biological_process "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] EOG8H1DBR GO:0007424 1/77 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8H1DBR GO:0035215 1/77 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8H1DBR GO:0000187 1/77 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG8H1DBR GO:0035231 1/77 cytoneme assembly biological_process "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901] EOG8H1DBR GO:0005104 1/77 fibroblast growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] EOG8H1DBR GO:0035152 1/77 regulation of tube architecture, open tracheal system biological_process "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] EOG8H1DBR GO:0007426 1/77 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8H1DBR GO:0007429 1/77 secondary branching, open tracheal system biological_process "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8H1DBR GO:0007427 1/77 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8H1DBR GO:0007428 1/77 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8H1DBR GO:0050918 1/77 positive chemotaxis biological_process "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] EOG8H1DBR GO:0001763 1/77 morphogenesis of a branching structure biological_process "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] EOG8H1DBR GO:0008347 1/77 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8323DS GO:0004602 3/9 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8323DS GO:0006979 3/9 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8ZCWKK GO:0006334 4/18 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8ZCWKK GO:0005634 4/18 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZCWKK GO:0000786 4/18 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8ZCWKK GO:0003677 4/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8W6R9Z GO:0005576 1/44 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8KM1JK GO:0098519 21/62 nucleotide phosphatase activity, acting on free nucleotides molecular_function "Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate." [GOC:dos] EOG8KM1JK GO:0005524 12/62 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1JK GO:0017111 12/62 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8KM1JK GO:0007476 1/62 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8KM1JK GO:0016740 1/62 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8WDGS0 GO:0010629 1/97 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8WDGS0 GO:0042826 1/97 histone deacetylase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] EOG8WDGS0 GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WDGS0 GO:0046872 1/97 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M947F GO:0005975 32/195 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8M947F GO:0004553 32/195 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8M947F GO:0045088 1/195 regulation of innate immune response biological_process "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8M947F GO:0032491 1/195 detection of molecule of fungal origin biological_process "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] EOG8M947F GO:0009986 1/195 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8M947F GO:0002758 1/195 innate immune response-activating signal transduction biological_process "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8M947F GO:0045087 1/195 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8M947F GO:0002221 1/195 pattern recognition receptor signaling pathway biological_process "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] EOG8M947F GO:0051607 1/195 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8M947F GO:0008329 1/195 signaling pattern recognition receptor activity molecular_function "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor] EOG8M947F GO:0001872 1/195 (1->3)-beta-D-glucan binding molecular_function "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] EOG8M947F GO:0009620 1/195 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG8M947F GO:0005576 1/195 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8WDGSR GO:0005622 7/98 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8WDGSR GO:0005215 7/98 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8WDGSR GO:0005501 1/98 retinoid binding molecular_function "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] EOG8WDGSR GO:0007602 1/98 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8WDGSR GO:0016063 1/98 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8PK4Q6 GO:0005578 1/15 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8PK4Q6 GO:0005886 1/15 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PK4Q6 GO:0031225 1/15 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG83R61F GO:0031409 16/120 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG83R61F GO:0005576 11/120 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG83R61F GO:0005215 4/120 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG83R61F GO:0036094 3/120 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG83R61F GO:0030682 3/120 evasion or tolerance of host defense response biological_process "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] EOG83R61F GO:0005501 2/120 retinoid binding molecular_function "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] EOG8V9X4Z GO:0008234 1/23 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8V9X4Z GO:0008270 1/23 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NS5VS GO:0005975 25/144 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8NS5VS GO:0016853 25/144 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8NS5VS GO:0030246 25/144 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8NS5VS GO:0034389 1/144 lipid particle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] EOG8NS5VS GO:0007030 1/144 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8V9X4V GO:0072546 27/83 ER membrane protein complex cellular_component "A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, PMID:19325107] EOG8ZCWK8 GO:0007165 21/84 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8ZCWK8 GO:0005509 21/84 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8ZCWK8 GO:0005578 21/84 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8ZCWK8 GO:0030513 1/84 positive regulation of BMP signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] EOG8ZCWK8 GO:0043395 1/84 heparan sulfate proteoglycan binding molecular_function "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732] EOG8ZCWK8 GO:0044719 1/84 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG8ZCWK8 GO:0030510 1/84 regulation of BMP signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] EOG8ZCWK8 GO:0008340 1/84 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8ZCWK8 GO:0030718 1/84 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8ZCWK8 GO:0005576 1/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG83R61V GO:0020037 24/59 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83R61V GO:0005506 24/59 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83R61V GO:0016705 23/59 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83R61V GO:0004497 22/59 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83R61V GO:0070330 1/59 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8QNQ9H GO:0003951 39/105 NAD+ kinase activity molecular_function "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] EOG8QNQ9H GO:0007205 36/105 protein kinase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] EOG8QNQ9H GO:0004143 36/105 diacylglycerol kinase activity molecular_function "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] EOG8QNQ9H GO:0017050 2/105 D-erythro-sphingosine kinase activity molecular_function "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] EOG8QNQ9H GO:0016310 2/105 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8QNQ9H GO:0006665 2/105 sphingolipid metabolic process biological_process "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8QNQ9H GO:0001729 2/105 ceramide kinase activity molecular_function "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] EOG8QNQ9H GO:0007629 1/105 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8QNQ9H GO:0018991 1/105 oviposition biological_process "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] EOG8V9X4G GO:0030239 1/60 myofibril assembly biological_process "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] EOG8V9X4G GO:0004222 1/60 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8V9X4G GO:0016021 1/60 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V9X4G GO:0019867 1/60 outer membrane cellular_component "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] EOG8STVN8 GO:0008270 1/6 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8STVN8 GO:0046872 1/6 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8STVN8 GO:0005634 1/6 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MWBMX GO:0005622 143/592 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MWBMX GO:0005215 143/592 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8MWBMX GO:0022008 1/592 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MWBMX GO:0016787 1/592 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8N06WX GO:0000166 3/10 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8N06WX GO:0003676 2/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87DCX7 GO:0008061 105/374 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87DCX7 GO:0006030 105/374 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87DCX7 GO:0005576 103/374 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87DCX7 GO:0005615 2/374 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG87DCX7 GO:0010716 1/374 negative regulation of extracellular matrix disassembly biological_process "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] EOG87DCX7 GO:0032504 1/374 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG87DCX7 GO:0040003 1/374 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8909Q3 GO:0004984 23/76 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8909Q3 GO:0005549 23/76 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8909Q3 GO:0004930 18/76 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8909Q3 GO:0016021 18/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8909Q3 GO:0005886 12/76 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8909Q3 GO:0016020 5/76 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8909Q2 GO:0003684 3/10 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8909Q2 GO:0006289 3/10 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8909Q2 GO:0005634 3/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N06WF GO:0008430 23/64 selenium binding molecular_function "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] EOG8N06WF GO:0045454 23/64 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8HHRKM GO:0016021 6/37 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HHRKM GO:0004935 4/37 adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] EOG8HHRKM GO:0004930 2/37 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8HHRKM GO:0004715 1/37 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8KPWR3 GO:0016021 25/110 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KPWR3 GO:0004252 24/110 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8KPWR3 GO:0005783 1/110 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8KPWR3 GO:0015031 1/110 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8KPWR3 GO:0008270 1/110 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8KPWR3 GO:0010841 1/110 positive regulation of circadian sleep/wake cycle, wakefulness biological_process "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb] EOG8KPWR3 GO:0003676 1/110 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KPWR3 GO:0030431 1/110 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8KPWR3 GO:0042059 1/110 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8KPWR3 GO:0005789 1/110 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8KPWR3 GO:0006508 1/110 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8KPWR3 GO:0042058 1/110 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG85QKVG GO:0005840 31/100 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG85QKVG GO:0003735 31/100 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG85QKVG GO:0006412 31/100 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG85QKVG GO:0007052 1/100 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG85QKVG GO:0051298 1/100 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG85QKVG GO:0000022 1/100 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG85QKVG GO:0051297 1/100 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8SN42X GO:0003824 27/204 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN42X GO:0004802 3/204 transketolase activity molecular_function "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] EOG8SN42X GO:0005875 2/204 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8SN42X GO:0031122 2/204 cytoplasmic microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] EOG8SN42X GO:0090063 1/204 positive regulation of microtubule nucleation biological_process "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] EOG8SN42X GO:0000922 1/204 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8SN42X GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SN42X GO:0005813 1/204 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8SN42X GO:0007067 1/204 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8SN42X GO:0007029 1/204 endoplasmic reticulum organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] EOG8SN42X GO:0008017 1/204 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8SN42X GO:0007143 1/204 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8SN42X GO:0048477 1/204 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8SN42X GO:0035371 1/204 microtubule plus-end cellular_component "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] EOG8SN42X GO:0045450 1/204 bicoid mRNA localization biological_process "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] EOG8SN42X GO:0031935 1/204 regulation of chromatin silencing biological_process "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] EOG8SN42X GO:0007344 1/204 pronuclear fusion biological_process "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] EOG8SN42X GO:0016325 1/204 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8SN42X GO:0005811 1/204 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8SN42X GO:0007017 1/204 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8SN42X GO:0000022 1/204 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8SN42X GO:0007411 1/204 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SN42X GO:0015631 1/204 tubulin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] EOG8J9QGG GO:0016021 3/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J9QGG GO:0005230 3/30 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG85QKV1 GO:0004984 5/30 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG85QKV1 GO:0016021 5/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85QKV1 GO:0004930 5/30 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG85QKV1 GO:0005549 5/30 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG85QKV1 GO:0005886 4/30 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MWBM9 GO:0016705 16/69 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8MWBM9 GO:0020037 16/69 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8MWBM9 GO:0005506 16/69 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8MWBM9 GO:0004497 15/69 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG87DCXC GO:0005549 2/6 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG87DCXC GO:0004930 2/6 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG87DCXC GO:0016021 2/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCXC GO:0004984 2/6 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG87DCXC GO:0005886 1/6 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88GZJ8 GO:0003743 2/77 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG88GZJ8 GO:0009987 1/77 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG88GZJ8 GO:0005515 1/77 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88GZJ8 GO:0045944 1/77 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG88GZJ8 GO:0005669 1/77 transcription factor TFIID complex cellular_component "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] EOG88GZJ8 GO:0006367 1/77 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8909QR GO:0008080 45/106 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8909QR GO:0016747 20/106 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG89625W GO:0010508 1/97 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG89625W GO:0046330 1/97 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG89625W GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89625W GO:0030054 1/97 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG89625W GO:0034599 1/97 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG89625W GO:0009267 1/97 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8PZMN4 GO:0004252 6/26 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8B013D GO:0005549 5/41 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8B013D GO:0004930 5/41 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8B013D GO:0016021 5/41 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B013D GO:0004984 5/41 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8B013D GO:0005886 5/41 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8S4RVZ GO:0004252 5/28 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C2KQW GO:0004474 6/15 malate synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184] EOG8C2KQW GO:0006097 6/15 glyoxylate cycle biological_process "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] EOG851H4V GO:0046872 1/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG851H4V GO:0031225 1/13 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG851H4V GO:0008235 1/13 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG851H4V GO:0008239 1/13 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG851H4V GO:0016805 1/13 dipeptidase activity molecular_function "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] EOG851H4X GO:0016021 117/291 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG851H4X GO:0007155 117/291 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG851H4X GO:0048102 2/291 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG851H4X GO:0005044 2/291 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG851H4X GO:0016063 2/291 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG851H4X GO:0007602 2/291 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG851H4X GO:0035071 2/291 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG851H4X GO:0006898 2/291 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG851H4X GO:0002433 1/291 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis biological_process "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] EOG851H4X GO:0006909 1/291 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG851H4X GO:0006911 1/291 phagocytosis, engulfment biological_process "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] EOG851H4X GO:0006915 1/291 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG851H4X GO:0006955 1/291 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG851H4X GO:0046867 1/291 carotenoid transport biological_process "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] EOG851H4X GO:0016116 1/291 carotenoid metabolic process biological_process "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] EOG851H4X GO:0042116 1/291 macrophage activation biological_process "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] EOG851H4X GO:0005886 1/291 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG851H4X GO:0050764 1/291 regulation of phagocytosis biological_process "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] EOG851H4X GO:0004872 1/291 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG851H4X GO:0043052 1/291 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG851H4X GO:0005764 1/291 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG85B3Z6 GO:0019789 31/81 SUMO transferase activity molecular_function "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] EOG85B3Z6 GO:0000724 31/81 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG85B3Z6 GO:0030915 31/81 Smc5-Smc6 complex cellular_component "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] EOG85B3Z6 GO:0008270 1/81 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88KTV9 GO:0016301 1/63 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8QRKN6 GO:0000276 38/99 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) cellular_component "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] EOG8QRKN6 GO:0015986 38/99 ATP synthesis coupled proton transport biological_process "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] EOG8QRKN6 GO:0015078 37/99 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8QRKN6 GO:0005811 1/99 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8QRKN6 GO:0008553 1/99 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] EOG85F03X GO:0016020 1/13 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85F03X GO:0005234 1/13 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG85F03X GO:0004970 1/13 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8TF31F GO:0005875 2/137 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8TF31F GO:0003676 1/137 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TF31F GO:0008270 1/137 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SFCKV GO:0003676 9/43 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SFCKV GO:0006310 9/43 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8SFCKV GO:0006260 9/43 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8SFCKV GO:0005524 9/43 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SFCKV GO:0043140 9/43 ATP-dependent 3'-5' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] EOG8SFCKV GO:0006281 9/43 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8SFCKV GO:0005622 6/43 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8PZMND GO:0008080 3/16 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8PZMND GO:0016747 1/16 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8284GG GO:0016602 22/84 CCAAT-binding factor complex cellular_component "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bm, PMID:7828851] EOG8284GG GO:0043565 22/84 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8284GG GO:0003700 22/84 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8284GG GO:0009987 1/84 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8284GG GO:0007411 1/84 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8284GG GO:0003887 1/84 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8RJJH7 GO:0001510 26/88 RNA methylation biological_process "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] EOG8RJJH7 GO:0008168 26/88 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8RJJH7 GO:0051301 2/88 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8RJJH7 GO:0006364 1/88 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8284GZ GO:0003700 29/114 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8284GZ GO:0043565 29/114 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8284GZ GO:0005634 26/114 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8284GZ GO:0007275 17/114 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8284GZ GO:0022008 1/114 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8284GZ GO:0006351 1/114 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG83N9SZ GO:0005975 52/148 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG83N9SZ GO:0004565 47/148 beta-galactosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] EOG83N9SZ GO:0004553 5/148 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG83N9SZ GO:0048102 1/148 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG83N9SZ GO:0035071 1/148 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8VQD5Z GO:0045089 1/11 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8VQD5Z GO:0050829 1/11 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG847J7B GO:0004252 8/26 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG847J7B GO:0006030 1/26 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG847J7B GO:0005576 1/26 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG847J7B GO:0008061 1/26 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8R7XQH GO:0046872 2/18 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG847J7X GO:0001700 1/101 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG86HJS8 GO:0005524 50/177 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86HJS8 GO:0019205 33/177 nucleobase-containing compound kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] EOG86HJS8 GO:0006139 33/177 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG86HJS8 GO:0004017 17/177 adenylate kinase activity molecular_function "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] EOG86HJS8 GO:0046034 14/177 ATP metabolic process biological_process "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] EOG86HJS8 GO:0005737 14/177 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86HJS8 GO:0046939 1/177 nucleotide phosphorylation biological_process "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] EOG86HJS8 GO:0004849 1/177 uridine kinase activity molecular_function "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] EOG83N9SM GO:0004252 3/15 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8VQD57 GO:0005789 26/85 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8VQD57 GO:0016021 26/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VQD57 GO:0016758 26/85 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8VQD57 GO:0006506 26/85 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG8616N8 GO:0003676 7/1106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616N8 GO:0003677 3/1106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8616N8 GO:0008270 3/1106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8616N8 GO:0003964 2/1106 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8616N8 GO:0015074 2/1106 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8616N8 GO:0003723 2/1106 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8616N8 GO:0004190 1/1106 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8616N8 GO:0008237 1/1106 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8F7R2N GO:0003676 9/101 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F7R2N GO:0008270 9/101 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F7R2N GO:0046872 1/101 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8F7R2N GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K0T48 GO:0016021 1/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K0T48 GO:0030054 1/13 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8K0T48 GO:0045211 1/13 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8K0T48 GO:0004889 1/13 acetylcholine-activated cation-selective channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] EOG86HJSW GO:0016740 1/28 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8X9B1C GO:0003700 1/17 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X9B1C GO:0008270 1/17 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X9B1C GO:0043565 1/17 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8284G8 GO:0016021 294/728 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284G8 GO:0055085 283/728 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8284G8 GO:0005215 14/728 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8284G8 GO:0015114 10/728 phosphate ion transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] EOG8284G8 GO:0005886 2/728 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8284G8 GO:0006814 2/728 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8284G8 GO:0015293 2/728 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8284G8 GO:0005314 1/728 high-affinity glutamate transmembrane transporter activity molecular_function "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] EOG8284G8 GO:0015321 1/728 sodium-dependent phosphate transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] EOG8284G8 GO:0051938 1/728 L-glutamate import biological_process "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] EOG8284G8 GO:0048190 1/728 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8284G8 GO:0006541 1/728 glutamine metabolic process biological_process "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] EOG8284G8 GO:0035725 1/728 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8284G8 GO:0001666 1/728 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8284G8 GO:0007005 1/728 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8284G8 GO:0035435 1/728 phosphate ion transmembrane transport biological_process "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] EOG8284G8 GO:0044341 1/728 sodium-dependent phosphate transport biological_process "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl] EOG8284G8 GO:0005436 1/728 sodium:phosphate symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] EOG8284G8 GO:0004930 1/728 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8HX7F1 GO:0005524 29/93 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HX7F1 GO:0003677 29/93 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8HX7F1 GO:0042555 27/93 MCM complex cellular_component "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] EOG8HX7F1 GO:0005634 27/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HX7F1 GO:0006270 27/93 DNA replication initiation biological_process "The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] EOG8HX7F1 GO:0003678 27/93 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8HX7F1 GO:0006260 3/93 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8HX7F1 GO:0030261 1/93 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8HX7F1 GO:0016020 1/93 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HX7F1 GO:0008234 1/93 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8HX7F1 GO:0032508 1/93 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8HX7F1 GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8HX7F1 GO:0022008 1/93 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8HX7F1 GO:0005272 1/93 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8HX7F1 GO:0046872 1/93 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HX7F1 GO:0051301 1/93 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8HX7F1 GO:0046331 1/93 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8HX7F1 GO:0007049 1/93 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8HX7F6 GO:0004867 1/109 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8WDGRM GO:0003735 47/309 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8WDGRM GO:0005840 47/309 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8WDGRM GO:0006412 47/309 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WDGRM GO:0005875 4/309 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8WDGRM GO:0005634 4/309 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGRM GO:0005829 3/309 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8WDGRM GO:0003950 3/309 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG8WDGRM GO:0009987 2/309 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8WDGRM GO:0022008 1/309 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WDGRM GO:0046872 1/309 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WDGRM GO:2000242 1/309 negative regulation of reproductive process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] EOG8WDGRM GO:0051438 1/309 regulation of ubiquitin-protein transferase activity biological_process "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] EOG8WDGRM GO:0010992 1/309 ubiquitin homeostasis biological_process "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb] EOG8WDGRM GO:0031386 1/309 protein tag molecular_function "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators] EOG8WDGRM GO:0006464 1/309 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8WDGRM GO:0045116 1/309 protein neddylation biological_process "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] EOG8WDGRM GO:0048812 1/309 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8WDGRM GO:0008283 1/309 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8WDGRM GO:0007141 1/309 male meiosis I biological_process "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] EOG8WDGRM GO:0048515 1/309 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8WDGRM GO:0030431 1/309 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8WDGRM GO:0031647 1/309 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8WDGRM GO:0006511 1/309 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8WDGRM GO:0030162 1/309 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8WDGRM GO:0008589 1/309 regulation of smoothened signaling pathway biological_process "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8WDGRM GO:0022625 1/309 cytosolic large ribosomal subunit cellular_component "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] EOG8WDGRM GO:0006909 1/309 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8WDGRM GO:0008340 1/309 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG83V290 GO:0004478 2/15 methionine adenosyltransferase activity molecular_function "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] EOG83V290 GO:0006556 2/15 S-adenosylmethionine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] EOG83V290 GO:0005524 2/15 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83V290 GO:0006730 1/15 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG83V290 GO:0046872 1/15 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WDGRQ GO:0004970 1/6 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8WDGRQ GO:0005234 1/6 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8WDGRQ GO:0016020 1/6 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M946H GO:0008270 1/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M946H GO:0003676 1/5 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PP105 GO:0007049 34/103 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8PP105 GO:0006221 13/103 pyrimidine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8PP105 GO:0045747 1/103 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8PP105 GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PP105 GO:0006207 1/103 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG873S63 GO:0008270 19/457 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG873S63 GO:0046872 3/457 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG873S63 GO:0016020 1/457 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG873S63 GO:0007165 1/457 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG873S63 GO:0016192 1/457 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG873S67 GO:0005525 24/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG873S67 GO:0003924 23/90 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG83R62C GO:0003677 25/78 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83R62C GO:0003682 24/78 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG83R62C GO:0005634 23/78 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83R62C GO:0008270 21/78 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83R62C GO:0006338 1/78 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG83R62C GO:0006355 1/78 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83R62C GO:0000124 1/78 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG83R62C GO:0035066 1/78 positive regulation of histone acetylation biological_process "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] EOG83R62C GO:0005700 1/78 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG83R62C GO:0043966 1/78 histone H3 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] EOG83R62C GO:0006351 1/78 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG83R62C GO:0005515 1/78 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83R62C GO:0035222 1/78 wing disc pattern formation biological_process "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] EOG83R62C GO:0007412 1/78 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8ZGRVD GO:0005549 3/12 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG81K1VF GO:0071011 1/77 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG81K1VF GO:0000398 1/77 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG81K1VF GO:0071013 1/77 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG873S6X GO:0005549 2/23 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG873S6Z GO:0006979 2/89 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG873S6Z GO:0008344 1/89 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG81K1VN GO:0003676 2/52 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81K1VN GO:0000502 1/52 proteasome complex cellular_component "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] EOG8TTJXT GO:0005581 13/81 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8TTJXT GO:0005201 12/81 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG83FK9M GO:0008270 74/433 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83FK9M GO:0009058 72/433 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG83FK9M GO:0016491 46/433 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG83FK9M GO:0016747 38/433 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG83FK9M GO:0016788 37/433 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG83FK9M GO:0004313 36/433 [acyl-carrier-protein] S-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] EOG83FK9M GO:0004315 35/433 3-oxoacyl-[acyl-carrier-protein] synthase activity molecular_function "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] EOG83FK9M GO:0004319 35/433 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity molecular_function "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] EOG83FK9M GO:0016295 35/433 myristoyl-[acyl-carrier-protein] hydrolase activity molecular_function "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727] EOG83FK9M GO:0004320 35/433 oleoyl-[acyl-carrier-protein] hydrolase activity molecular_function "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] EOG83FK9M GO:0016296 35/433 palmitoyl-[acyl-carrier-protein] hydrolase activity molecular_function "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549] EOG83FK9M GO:0004316 35/433 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG83FK9M GO:0004314 35/433 [acyl-carrier-protein] S-malonyltransferase activity molecular_function "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] EOG83FK9M GO:0004317 35/433 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] EOG83FK9M GO:0016740 23/433 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG83FK9M GO:0004312 19/433 fatty acid synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] EOG83FK9M GO:0047451 3/433 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN] EOG83FK9M GO:0003960 2/433 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG83FK9M GO:0005811 2/433 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG83FK9M GO:0050111 1/433 mycocerosate synthase activity molecular_function "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591] EOG8TTJXX GO:0008270 50/79 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TTJXX GO:0008237 50/79 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8TTJXX GO:0004177 6/79 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8TTJXX GO:0006508 2/79 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8TTJXZ GO:0006464 16/27 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8TTJXZ GO:0004835 2/27 tubulin-tyrosine ligase activity molecular_function "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] EOG8TTJXZ GO:0005634 1/27 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTJXZ GO:0007283 1/27 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8TTJXZ GO:0070735 1/27 protein-glycine ligase activity molecular_function "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510] EOG8TTJXZ GO:0018094 1/27 protein polyglycylation biological_process "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] EOG8TTJXZ GO:0070736 1/27 protein-glycine ligase activity, initiating molecular_function "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510] EOG8TTJXZ GO:0042384 1/27 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8TTJXZ GO:0005930 1/27 axoneme cellular_component "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] EOG8TTJXZ GO:0035082 1/27 axoneme assembly biological_process "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] EOG8TTJXZ GO:0005874 1/27 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8TTJXZ GO:0007291 1/27 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8TTJXZ GO:0070737 1/27 protein-glycine ligase activity, elongating molecular_function "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510] EOG8TTJXZ GO:0015630 1/27 microtubule cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] EOG83FK9Z GO:0008080 10/93 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG83FK9Z GO:0000785 9/93 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG83FK9Z GO:0007062 9/93 sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194] EOG83FK9Z GO:0034421 9/93 post-translational protein acetylation biological_process "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah] EOG83FK9Z GO:0006275 9/93 regulation of DNA replication biological_process "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] EOG83FK9Z GO:0046872 2/93 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83FK9Z GO:0000790 1/93 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG83FK9Z GO:0007064 1/93 mitotic sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] EOG83FK9Z GO:0016407 1/93 acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] EOG83FK9Z GO:0008152 1/93 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG83FK9Z GO:0007052 1/93 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG83V29G GO:0042384 1/79 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG88D3BT GO:0005750 33/98 mitochondrial respiratory chain complex III cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] EOG88D3BT GO:0006122 33/98 mitochondrial electron transport, ubiquinol to cytochrome c biological_process "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] EOG88D3BT GO:0016491 3/98 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG88D3BT GO:0008340 1/98 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG88D3BT GO:0000302 1/98 response to reactive oxygen species biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] EOG88D3BT GO:0008121 1/98 ubiquinol-cytochrome-c reductase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] EOG88D3BT GO:0034551 1/98 mitochondrial respiratory chain complex III assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc] EOG82FW14 GO:0016020 26/128 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82FW14 GO:0016192 26/128 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG82FW14 GO:0006886 26/128 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG82FW14 GO:0005484 1/128 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG82FW14 GO:0016740 1/128 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG82FW10 GO:0003954 1/72 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8Z6542 GO:0004930 5/35 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8Z6542 GO:0016021 5/35 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z6542 GO:0007275 5/35 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8Z6542 GO:0016055 5/35 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8X3KHJ GO:0008270 126/815 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X3KHJ GO:0003676 118/815 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X3KHJ GO:0003964 12/815 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8X3KHJ GO:0003723 12/815 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8X3KHJ GO:0003677 1/815 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X3KHJ GO:0016192 1/815 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8X3KHJ GO:0015074 1/815 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8X3KHJ GO:0016020 1/815 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82Z746 GO:0005634 4/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82Z746 GO:0008270 4/62 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82Z746 GO:0003677 3/62 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82Z746 GO:0003676 3/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82Z746 GO:0046872 2/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8909PV GO:0016021 2/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8909PV GO:0005886 2/21 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8909PV GO:0050909 2/21 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8CC6F8 GO:0008270 1/103 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CC6F8 GO:0035859 1/103 Seh1-associated complex cellular_component "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] EOG8BGCCF GO:0030246 20/118 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BGCCF GO:0016787 2/118 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BGCCF GO:0006614 1/118 SRP-dependent cotranslational protein targeting to membrane biological_process "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] EOG8BGCCF GO:0008312 1/118 7S RNA binding molecular_function "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] EOG8BGCCF GO:0048500 1/118 signal recognition particle cellular_component "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] EOG8BZQGT GO:0016021 35/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BZQGT GO:0005230 25/146 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8BZQGT GO:0005886 21/146 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BZQGT GO:0006811 10/146 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8BZQGT GO:1902476 1/146 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG8BZQGT GO:0005254 1/146 chloride channel activity molecular_function "Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8BZQGT GO:0006821 1/146 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8BZQGT GO:0022008 1/146 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8HMMQN GO:0005634 25/145 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HMMQN GO:0005737 8/145 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HMMQN GO:0030512 8/145 negative regulation of transforming growth factor beta receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] EOG8HMMQN GO:0003714 8/145 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8HMMQN GO:0003677 2/145 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8HMMQN GO:0030514 2/145 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8HMMQN GO:0000122 1/145 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8HMMQN GO:0070410 1/145 co-SMAD binding molecular_function "Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] EOG8HMMQN GO:0007474 1/145 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8CC6FJ GO:0030659 2/135 cytoplasmic vesicle membrane cellular_component "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] EOG8CC6FJ GO:0005856 2/135 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8CC6FJ GO:0005886 2/135 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8CC6FJ GO:0048471 2/135 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8CC6FJ GO:0015031 2/135 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8CC6FJ GO:0030029 1/135 actin filament-based process biological_process "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] EOG8CC6FJ GO:0045010 1/135 actin nucleation biological_process "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] EOG8CC6FJ GO:0005515 1/135 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CC6FJ GO:0045451 1/135 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8CC6FJ GO:0007315 1/135 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8CC6FJ GO:0008017 1/135 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8CC6FJ GO:0007304 1/135 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8CC6FJ GO:0051639 1/135 actin filament network formation biological_process "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai] EOG8CC6FJ GO:0005938 1/135 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8CC6FJ GO:0048477 1/135 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8CC6FJ GO:0007015 1/135 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8CC6FJ GO:0005737 1/135 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CC6FJ GO:0030717 1/135 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8CC6FJ GO:0051493 1/135 regulation of cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] EOG8CC6FJ GO:0003779 1/135 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8CC6FJ GO:0016192 1/135 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8CC6FJ GO:0030036 1/135 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8CC6FJ GO:0007275 1/135 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8CC6FJ GO:0007316 1/135 pole plasm RNA localization biological_process "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG82Z74T GO:0016905 2/93 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG82Z74T GO:0044666 1/93 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG82Z74T GO:0005875 1/93 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG82Z74T GO:0048188 1/93 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG82Z74T GO:0005634 1/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82Z74T GO:0007095 1/93 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG82Z74T GO:0006338 1/93 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG82Z74T GO:0044545 1/93 NSL complex cellular_component "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] EOG82Z74T GO:0051568 1/93 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG82Z74T GO:0022008 1/93 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82Z74T GO:0005671 1/93 Ada2/Gcn5/Ada3 transcription activator complex cellular_component "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] EOG82Z74T GO:0016573 1/93 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8CC6FF GO:0005524 25/87 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CC6FF GO:0003676 25/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CC6FF GO:0008026 23/87 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8CC6FF GO:0004004 1/87 ATP-dependent RNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] EOG8CC6FF GO:0006200 1/87 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8CC6FF GO:0022008 1/87 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CC6FF GO:0004386 1/87 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8CRPFQ GO:0016021 23/139 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPFQ GO:0008080 21/139 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG82Z74N GO:0005549 3/9 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG82Z74N GO:0016021 3/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82Z74N GO:0004984 3/9 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG82Z74N GO:0004930 3/9 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG82Z74N GO:0005886 3/9 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8SBHC8 GO:0005525 1/32 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8CC6FZ GO:0005886 1/101 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8CC6FZ GO:0007275 1/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8CC6FZ GO:0005198 1/101 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8CC6FZ GO:0006629 1/101 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8CC6FZ GO:0016021 1/101 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CC6FZ GO:0016627 1/101 oxidoreductase activity, acting on the CH-CH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8CC6FZ GO:0016600 1/101 flotillin complex cellular_component "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] EOG8CC6FZ GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZCWJJ GO:0003677 1/20 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N335V GO:0043565 29/151 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8N335V GO:0003700 29/151 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8N335V GO:0005634 15/151 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N335V GO:0006351 13/151 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8N335V GO:0010259 12/151 multicellular organismal aging biological_process "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] EOG8N335V GO:0019216 12/151 regulation of lipid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] EOG8N335V GO:0030308 12/151 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8N335V GO:0006355 12/151 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8N335V GO:0042593 12/151 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG8N335V GO:0008285 12/151 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8N335V GO:0046627 12/151 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8N335V GO:0005737 12/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8N335V GO:0007049 11/151 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8N335V GO:0030154 10/151 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8N335V GO:0009617 1/151 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8N335V GO:0034599 1/151 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG8N335V GO:0008301 1/151 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG8N335V GO:0046626 1/151 regulation of insulin receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8N335V GO:0016241 1/151 regulation of macroautophagy biological_process "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] EOG8N335V GO:0010888 1/151 negative regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG8N335V GO:0001578 1/151 microtubule bundle formation biological_process "A process that results in a parallel arrangement of microtubules." [GOC:dph] EOG8N335V GO:0036099 1/151 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG8N335V GO:2000253 1/151 positive regulation of feeding behavior biological_process "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] EOG8N335V GO:0005515 1/151 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8N335V GO:0001077 1/151 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8N335V GO:0008340 1/151 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8N335V GO:0009267 1/151 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8N335V GO:0007476 1/151 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8N335V GO:0006974 1/151 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8N335V GO:0046872 1/151 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8N335V GO:0045944 1/151 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8N335V GO:0045893 1/151 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8N335V GO:0005829 1/151 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8N335V GO:0045792 1/151 negative regulation of cell size biological_process "Any process that reduces cell size." [GOC:go_curators] EOG8N335V GO:0035206 1/151 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8N335V GO:0040008 1/151 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG8N335V GO:0009888 1/151 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8N335V GO:0008286 1/151 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG8N335V GO:0007389 1/151 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8N335V GO:0048813 1/151 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8N335V GO:0006171 1/151 cAMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] EOG8N335V GO:0006979 1/151 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8N335V GO:0005977 1/151 glycogen metabolic process biological_process "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] EOG8N335V GO:0007623 1/151 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8N335V GO:0019901 1/151 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG8N335V GO:0001745 1/151 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8N335V GO:0034198 1/151 cellular response to amino acid starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] EOG8N335V GO:0001558 1/151 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8N335V GO:0003677 1/151 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N335V GO:0010506 1/151 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8N335V GO:1900078 1/151 positive regulation of cellular response to insulin stimulus biological_process "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] EOG8N335V GO:0040015 1/151 negative regulation of multicellular organism growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8N335Q GO:0003682 1/12 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG88D3B0 GO:0005886 1/28 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88D3B0 GO:0016021 1/28 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88D3B0 GO:0004984 1/28 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG88D3B0 GO:0004930 1/28 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG88D3B0 GO:0005549 1/28 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8Q87DM GO:0005622 4/16 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8Q87DM GO:0005215 4/16 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8ZCWJX GO:0005975 67/249 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8ZCWJX GO:0004370 42/249 glycerol kinase activity molecular_function "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647] EOG8ZCWJX GO:0006072 39/249 glycerol-3-phosphate metabolic process biological_process "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] EOG8ZCWJX GO:0016773 25/249 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8ZCWJX GO:0016301 22/249 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8ZCWJX GO:0046167 2/249 glycerol-3-phosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] EOG8MGVR2 GO:0022008 1/85 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MGVR2 GO:0005730 1/85 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8RNDS2 GO:0005525 26/112 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8RNDS2 GO:0007264 26/112 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8RNDS2 GO:0008060 23/112 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8RNDS2 GO:0032312 23/112 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8RNDS2 GO:0005622 23/112 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8RNDS2 GO:0008270 23/112 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RNDS2 GO:0016020 8/112 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RNDS2 GO:0006184 8/112 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8RNDS2 GO:0043547 1/112 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8HDW8F GO:0006886 37/164 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8HDW8F GO:0048193 24/164 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG8HDW8F GO:0016020 23/164 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HDW8F GO:0007269 2/164 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8HDW8F GO:0042147 1/164 retrograde transport, endosome to Golgi biological_process "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] EOG8HDW8F GO:0005886 1/164 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HDW8F GO:0016081 1/164 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG8HDW8F GO:0051726 1/164 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8HDW8F GO:0016021 1/164 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HDW8F GO:0006906 1/164 vesicle fusion biological_process "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] EOG8HDW8F GO:0016082 1/164 synaptic vesicle priming biological_process "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] EOG8HDW8F GO:0005483 1/164 soluble NSF attachment protein activity molecular_function "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] EOG8HDW8F GO:0016192 1/164 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8HDW8F GO:0005737 1/164 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HDW8F GO:0048190 1/164 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8HDW8F GO:0005484 1/164 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG8RNDS4 GO:0005634 23/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RNDS4 GO:0003700 22/92 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RNDS4 GO:0000976 16/92 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8RNDS4 GO:0043565 7/92 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RNDS4 GO:0007417 1/92 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8RNDS4 GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RNDS4 GO:0000122 1/92 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RNDS4 GO:0030182 1/92 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8RNDS4 GO:0006366 1/92 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8RNDS4 GO:0003705 1/92 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8RNDS4 GO:0010629 1/92 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8RNDS4 GO:0045944 1/92 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RNDS4 GO:0070491 1/92 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8G1PZ0 GO:0016881 44/171 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8G1PZ0 GO:0004842 6/171 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8G1PZ0 GO:0005524 2/171 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G1PZ0 GO:0048477 1/171 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8G1PZ0 GO:0051276 1/171 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8G1PZ0 GO:0007140 1/171 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8G1PZ0 GO:0007067 1/171 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8G1PZ0 GO:0006511 1/171 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8G1PZ0 GO:0031647 1/171 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8G1PZ0 GO:0005515 1/171 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8G1PZ0 GO:0005875 1/171 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8G1PZ0 GO:0016567 1/171 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8G1PZ0 GO:0045676 1/171 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8G1PZ0 GO:0048132 1/171 female germ-line stem cell asymmetric division biological_process "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] EOG8G1PZ0 GO:0007286 1/171 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8G1PZ0 GO:0001745 1/171 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8G1PZ0 GO:0019915 1/171 lipid storage biological_process "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] EOG8G1PZ0 GO:0022008 1/171 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8G1PZ0 GO:0030718 1/171 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8G1PZ0 GO:0001751 1/171 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8G1PZ0 GO:0016322 1/171 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8G1PZ0 GO:0008054 1/171 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG85F04T GO:0005525 11/88 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG85F04T GO:0000184 3/88 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG85F04T GO:0042332 1/88 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG85F04T GO:0005622 1/88 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8G7FFM GO:0005634 384/651 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G7FFM GO:0000786 384/651 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8G7FFM GO:0003677 384/651 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8G7FFM GO:0006334 384/651 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8G7FFM GO:0005811 50/651 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8G7FFM GO:0051298 17/651 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8G7FFM GO:0006281 1/651 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8G7FFM GO:0005701 1/651 polytene chromosome chromocenter cellular_component "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] EOG8G7FFM GO:0071168 1/651 protein localization to chromatin biological_process "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] EOG8G7FFM GO:0005700 1/651 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8G7FFM GO:0006974 1/651 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8G7FFM GO:0005694 1/651 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8G7FFM GO:0007275 1/651 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG85F04G GO:0005576 1/201 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85F04G GO:0046427 1/201 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8JHFX7 GO:0003676 22/75 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JHFX5 GO:0006412 39/111 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8JHFX5 GO:0003735 37/111 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8JHFX5 GO:0015935 37/111 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG8JHFX5 GO:0003723 36/111 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8JHFX5 GO:0005840 2/111 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8JHFX5 GO:0005737 1/111 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JHFX5 GO:0005875 1/111 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8JHFX5 GO:0007052 1/111 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8JHFX5 GO:0000022 1/111 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8JHFX5 GO:0022008 1/111 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8JHFX5 GO:0005730 1/111 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8JHFX5 GO:0000228 1/111 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG85XB9P GO:0004531 31/91 deoxyribonuclease II activity molecular_function "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] EOG85XB9P GO:0005622 1/91 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG85XB9P GO:0006308 1/91 DNA catabolic process biological_process "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] EOG85XB9P GO:0045476 1/91 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG85XB9P GO:0006309 1/91 apoptotic DNA fragmentation biological_process "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] EOG8CG2R8 GO:0003676 293/3952 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CG2R8 GO:0015074 167/3952 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CG2R8 GO:0008270 165/3952 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CG2R8 GO:0003723 66/3952 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CG2R8 GO:0003964 66/3952 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8CG2R8 GO:0004190 48/3952 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8CG2R8 GO:0005634 3/3952 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CG2R8 GO:0005509 3/3952 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8CG2R8 GO:0003677 3/3952 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CG2R8 GO:0016021 2/3952 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CG2R8 GO:0007166 2/3952 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8CG2R8 GO:0004842 2/3952 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8CG2R8 GO:0023051 2/3952 regulation of signaling biological_process "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] EOG8CG2R8 GO:0046872 2/3952 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CG2R8 GO:0004871 2/3952 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8CG2R8 GO:0003700 1/3952 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CG2R8 GO:0016620 1/3952 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8CG2R8 GO:0004527 1/3952 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8CG2R8 GO:0005524 1/3952 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CG2R8 GO:0055085 1/3952 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8CG2R8 GO:0043565 1/3952 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CG2R8 GO:0004518 1/3952 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8CG2R8 GO:0004672 1/3952 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8CG2R8 GO:0004725 1/3952 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8CG2R8 GO:0005840 1/3952 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8CG2R8 GO:0006412 1/3952 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8CG2R8 GO:0022857 1/3952 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8CG2R8 GO:0019031 1/3952 viral envelope cellular_component "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] EOG8CG2R8 GO:0003735 1/3952 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8CG2R8 GO:0016491 1/3952 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8CG2R8 GO:0005975 1/3952 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8P5NR3 GO:0003735 25/81 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8P5NR3 GO:0006412 25/81 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8P5NR3 GO:0005840 24/81 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8P5NR3 GO:0005762 1/81 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8P5NR2 GO:0008026 26/85 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8P5NR2 GO:0005524 26/85 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8P5NR2 GO:0003676 26/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8P5NR2 GO:0008152 1/85 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8P5NR2 GO:0005737 1/85 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P5NR2 GO:0004386 1/85 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8P5NR5 GO:0005524 1/16 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88GZKC GO:0005576 69/178 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88GZKC GO:0005615 10/178 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG88GZKC GO:0008286 3/178 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG88GZKC GO:0005158 3/178 insulin receptor binding molecular_function "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] EOG88GZKC GO:0060180 2/178 female mating behavior biological_process "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG88GZKC GO:0040007 1/178 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG88GZKC GO:0040009 1/178 regulation of growth rate biological_process "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] EOG88GZKC GO:0040014 1/178 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG88GZKC GO:0008340 1/178 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG88GZKC GO:0060250 1/178 germ-line stem-cell niche homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] EOG88GZKC GO:0046620 1/178 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG88GZKC GO:0009758 1/178 carbohydrate utilization biological_process "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg] EOG88GZKC GO:0070328 1/178 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG88GZKC GO:0030536 1/178 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG88GZKC GO:0030307 1/178 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG88GZKC GO:0008284 1/178 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG88GZKC GO:0040018 1/178 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG88GZKC GO:0008361 1/178 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG88GZKC GO:2000252 1/178 negative regulation of feeding behavior biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] EOG8P5NRB GO:0008897 13/48 holo-[acyl-carrier-protein] synthase activity molecular_function "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] EOG8P5NRB GO:0000287 13/48 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8P5NRB GO:0009059 13/48 macromolecule biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] EOG8N06VM GO:0005506 35/104 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8N06VM GO:0016705 35/104 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8N06VM GO:0020037 35/104 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8N06VM GO:0004497 34/104 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG815JTD GO:0004970 151/510 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG815JTD GO:0005234 151/510 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG815JTD GO:0030054 151/510 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG815JTD GO:0045211 149/510 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG815JTD GO:0016021 148/510 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG815JTD GO:0035235 8/510 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG815JTD GO:0034220 8/510 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG815JTD GO:0015277 7/510 kainate selective glutamate receptor activity molecular_function "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] EOG815JTD GO:0030425 6/510 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG815JTD GO:0008328 6/510 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG815JTD GO:0035249 5/510 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG815JTD GO:0005886 3/510 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG815JTD GO:0031594 3/510 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG815JTD GO:1900073 2/510 regulation of neuromuscular synaptic transmission biological_process "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG815JTD GO:0045202 2/510 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG815JTD GO:0036081 2/510 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG815JTD GO:0007274 2/510 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG815JTD GO:0008066 1/510 glutamate receptor activity molecular_function "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] EOG815JTD GO:0005215 1/510 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG815JTD GO:0043179 1/510 rhythmic excitation biological_process "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433] EOG815JTD GO:0051968 1/510 positive regulation of synaptic transmission, glutamatergic biological_process "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] EOG815JTD GO:0048812 1/510 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG815JTD GO:0007268 1/510 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG815JTD GO:0005509 1/510 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG815JTD GO:0046928 1/510 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG815JTD GO:0097482 1/510 muscle cell postsynaptic density cellular_component "A postsynaptic density that is part of a muscle cell." [GOC:pr] EOG815JTD GO:1900075 1/510 positive regulation of neuromuscular synaptic transmission biological_process "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG815JTD GO:0016020 1/510 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG815JTD GO:0060025 1/510 regulation of synaptic activity biological_process "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] EOG8SN43Q GO:0016491 14/77 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8SN43Q GO:0016630 1/77 protochlorophyllide reductase activity molecular_function "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] EOG85QKWD GO:0003700 19/42 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85F048 GO:0045454 13/79 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG85F048 GO:0016021 1/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85F048 GO:0016853 1/79 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8JHFXS GO:0003700 1/15 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8JHFXS GO:0043565 1/15 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8JHFXS GO:0005634 1/15 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JHFXP GO:0008237 2/17 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8G7FF7 GO:0008233 1/67 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8G7FF7 GO:0007521 1/67 muscle cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] EOG8G7FF7 GO:0005576 1/67 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8SN43C GO:0046872 2/22 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG815JTT GO:0005634 2/8 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG815JTT GO:0008270 2/8 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG815JTT GO:0003676 2/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG815JTT GO:0046872 1/8 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HHRK7 GO:0043565 6/42 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8HHRK7 GO:0005634 6/42 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HHRK7 GO:0003700 6/42 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86HJRM GO:0003676 4/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZH9 GO:0003677 23/70 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FTZH9 GO:0003899 23/70 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8FTZH9 GO:0008270 23/70 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZH9 GO:0006351 22/70 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0005665 1/70 DNA-directed RNA polymerase II, core complex cellular_component "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8FTZH9 GO:0006360 1/70 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0006366 1/70 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8FTZH9 GO:0006383 1/70 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0005736 1/70 DNA-directed RNA polymerase I complex cellular_component "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8FTZH9 GO:0005666 1/70 DNA-directed RNA polymerase III complex cellular_component "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG86HJRP GO:0005576 5/38 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG86HJRP GO:0005615 1/38 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8RV55G GO:0005634 1/45 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RV55G GO:0005886 1/45 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RV55G GO:0005737 1/45 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RV55G GO:0042826 1/45 histone deacetylase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] EOG8RV55G GO:0010629 1/45 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG837TTQ GO:0004842 32/106 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG837TTQ GO:0008270 20/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG837TTQ GO:0005886 1/106 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG837TTQ GO:0030509 1/106 BMP signaling pathway biological_process "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034] EOG837TTQ GO:0004252 1/106 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG837TTQ GO:0040011 1/106 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG837TTQ GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG837TTQ GO:0005515 1/106 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG837TTQ GO:0007628 1/106 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG837TTQ GO:0016567 1/106 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG837TTQ GO:0006914 1/106 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG837TTQ GO:0016023 1/106 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG837TTQ GO:0045886 1/106 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG837TTQ GO:2000331 1/106 regulation of terminal button organization biological_process "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] EOG837TTQ GO:0008582 1/106 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG837TTQ GO:0050808 1/106 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG837TTQ GO:0006351 1/106 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG837TTQ GO:0030514 1/106 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8W3W1S GO:0007156 53/168 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8W3W1S GO:0005509 53/168 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8W3W1S GO:0005886 52/168 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8W3W1S GO:0016021 52/168 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W3W1S GO:0030286 3/168 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8W3W1S GO:0003777 3/168 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8W3W1S GO:0007018 3/168 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8W3W1S GO:0001539 3/168 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG8W3W1S GO:0030031 3/168 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8W3W1S GO:0050839 2/168 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8W3W1S GO:0016339 2/168 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG8W3W1S GO:0004872 2/168 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8W3W1S GO:0048846 2/168 axon extension involved in axon guidance biological_process "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] EOG8W3W1S GO:0005887 2/168 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W3W1S GO:0004022 2/168 alcohol dehydrogenase (NAD) activity molecular_function "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] EOG8W3W1S GO:0045463 2/168 R8 cell development biological_process "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] EOG8W3W1S GO:0045467 2/168 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8W3W1S GO:0016318 2/168 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8W3W1S GO:0030425 1/168 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8W3W1S GO:0004725 1/168 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8W3W1S GO:0007413 1/168 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8W3W1S GO:0008013 1/168 beta-catenin binding molecular_function "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] EOG8W3W1S GO:0030424 1/168 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8W3W1S GO:0045296 1/168 cadherin binding molecular_function "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] EOG8W3W1S GO:0005515 1/168 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W3W1S GO:0050774 1/168 negative regulation of dendrite morphogenesis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8W3W1S GO:0007412 1/168 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8W3W1S GO:0005911 1/168 cell-cell junction cellular_component "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] EOG8W3W1S GO:0031290 1/168 retinal ganglion cell axon guidance biological_process "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] EOG8W3W1S GO:0048814 1/168 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8W3W1S GO:0007411 1/168 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8W3W1S GO:0048841 1/168 regulation of axon extension involved in axon guidance biological_process "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] EOG8W3W1S GO:0042803 1/168 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8W3W1S GO:0048675 1/168 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8W3W1S GO:0044331 1/168 cell-cell adhesion mediated by cadherin biological_process "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970] EOG8RV55J GO:0000375 2/91 RNA splicing, via transesterification reactions biological_process "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] EOG8RV55J GO:0005634 2/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RV55J GO:0000381 2/91 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8RV55J GO:0006397 2/91 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8RV55J GO:0007539 1/91 primary sex determination, soma biological_process "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] EOG8RV55J GO:0019099 1/91 female germ-line sex determination biological_process "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] EOG8RV55J GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RV55J GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RV55J GO:0007530 1/91 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG8RV55J GO:0007275 1/91 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG870WZS GO:0019843 28/92 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG870WZS GO:0003735 27/92 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG870WZS GO:0015935 27/92 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG870WZS GO:0006412 27/92 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG870WZS GO:0000228 1/92 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG870WZS GO:0005622 1/92 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG870WZS GO:0005730 1/92 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG870WZS GO:0005840 1/92 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG870WZS GO:0005737 1/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG870WZS GO:0000022 1/92 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG870WZS GO:0007052 1/92 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8VX4NW GO:0045454 1/41 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8VX4NW GO:0008430 1/41 selenium binding molecular_function "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] EOG879HMZ GO:0016772 69/190 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG879HMZ GO:0016301 11/190 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG879HMZ GO:0017022 1/190 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG879HMZ GO:0022008 1/190 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8RJJGS GO:0004252 4/14 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG870WZG GO:0005794 1/70 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG870WZG GO:0048193 1/70 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG870WZG GO:0000139 1/70 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG870WZG GO:0032440 1/70 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG870WZG GO:0007030 1/70 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG870WZG GO:0016021 1/70 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG870WZG GO:0042803 1/70 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8GTNT9 GO:0016787 15/26 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8GTNT9 GO:0052689 5/26 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8GTNT9 GO:0005576 4/26 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GTNT9 GO:0007618 1/26 mating biological_process "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] EOG8GTNT9 GO:0005615 1/26 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8GTNT9 GO:0046662 1/26 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG8GTNT9 GO:0042811 1/26 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8GTNT9 GO:0030728 1/26 ovulation biological_process "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] EOG8GTNT9 GO:0046008 1/26 regulation of female receptivity, post-mating biological_process "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] EOG8GTNT9 GO:0032504 1/26 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8GTNT9 GO:0046693 1/26 sperm storage biological_process "The retention of sperm by a female following mating." [PMID:10885514] EOG8GTNT9 GO:0007619 1/26 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83XXJS GO:0016021 1/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83XXJS GO:0000139 1/80 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG83XXJS GO:0015031 1/80 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG870WZN GO:0005524 52/162 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG870WZN GO:0016226 48/162 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG870WZN GO:0051539 48/162 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG870WZN GO:0046872 48/162 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG870WZN GO:0005737 33/162 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG870WZN GO:0005829 15/162 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG870WZN GO:0051536 15/162 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG870WZN GO:0017111 11/162 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG83XXJW GO:0016787 19/49 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG83XXJW GO:0008967 1/49 phosphoglycolate phosphatase activity molecular_function "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372] EOG8GTNT0 GO:0003676 5/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GTNT0 GO:0015074 4/105 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8GTNT0 GO:0008270 2/105 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG870WZ5 GO:0002098 24/71 tRNA wobble uridine modification biological_process "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] EOG870WZ5 GO:0000049 24/71 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG870WZ5 GO:0034227 24/71 tRNA thio-modification biological_process "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] EOG870WZ5 GO:0032447 21/71 protein urmylation biological_process "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] EOG870WZ5 GO:0016779 21/71 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG870WZ5 GO:0005829 15/71 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG870WZ5 GO:0005737 7/71 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG870WZ5 GO:0016757 1/71 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SR09G GO:0004252 2/21 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8CNT5J GO:0016773 12/40 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8CNT5J GO:0004001 4/40 adenosine kinase activity molecular_function "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] EOG8CNT5J GO:0006166 3/40 purine ribonucleoside salvage biological_process "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] EOG8CNT5J GO:0016301 1/40 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG870WZ8 GO:0004984 2/7 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG870WZ8 GO:0005549 2/7 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG870WZ8 GO:0005886 1/7 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG870WZ8 GO:0004930 1/7 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG870WZ8 GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG870WZ8 GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CNT5M GO:0007165 8/439 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8CNT5M GO:0016021 1/439 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CNT5M GO:0022891 1/439 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8CNT5M GO:0006909 1/439 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8CNT5M GO:0035330 1/439 regulation of hippo signaling biological_process "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] EOG8CNT5M GO:0031410 1/439 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8CNT5P GO:0008061 3/19 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8CNT5P GO:0005576 3/19 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CNT5P GO:0006030 3/19 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8DFS3C GO:0005634 3/9 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DFS3C GO:0003676 3/9 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DFS3C GO:0008270 3/9 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DFS3C GO:0003677 1/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DFS3C GO:0006355 1/9 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8DFS3C GO:0004129 1/9 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8DFS3C GO:0046872 1/9 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RJJG3 GO:0005887 1/86 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RWG GO:0004003 29/96 ATP-dependent DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] EOG8S4RWG GO:0000439 29/96 core TFIIH complex cellular_component "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] EOG8S4RWG GO:0006289 29/96 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8S4RWG GO:0010224 1/96 response to UV-B biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] EOG8S4RWG GO:0006366 1/96 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8S4RWG GO:0001671 1/96 ATPase activator activity molecular_function "Binds to and increases the ATP hydrolysis activity of an ATPase." [GOC:ajp] EOG8S4RWG GO:0006367 1/96 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8S4RWG GO:2001141 1/96 regulation of RNA biosynthetic process biological_process "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] EOG8S4RWG GO:0032781 1/96 positive regulation of ATPase activity biological_process "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] EOG8S4RWG GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S4RWG GO:0005675 1/96 holo TFIIH complex cellular_component "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] EOG8CNT5W GO:0030060 17/34 L-malate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] EOG8CNT5W GO:0006108 17/34 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG8CNT5W GO:0044262 17/34 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG8CNT5W GO:0006099 3/34 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8CNT5W GO:0005811 1/34 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8CNT5W GO:0005739 1/34 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8CNT5W GO:0035070 1/34 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8CNT5W GO:0035209 1/34 pupal development biological_process "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu] EOG8CNT5W GO:0043068 1/34 positive regulation of programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8CNT5W GO:0043067 1/34 regulation of programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8CNT5W GO:0016615 1/34 malate dehydrogenase activity molecular_function "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] EOG8CNT5W GO:0006919 1/34 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG83XXJ5 GO:0006511 23/108 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG83XXJ5 GO:0008234 16/108 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG83XXJ5 GO:0004221 2/108 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG83XXJ5 GO:0045880 1/108 positive regulation of smoothened signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG83XXJ5 GO:0016579 1/108 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG83XXJ5 GO:0008587 1/108 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG83XXJ5 GO:0090263 1/108 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG83XXJ5 GO:0005737 1/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83XXJ5 GO:0004843 1/108 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG8S4RWM GO:0005634 28/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S4RWM GO:0003684 28/103 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8S4RWM GO:0000012 28/103 single strand break repair biological_process "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] EOG8S4RWM GO:0006285 1/103 base-excision repair, AP site formation biological_process "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] EOG8S4RWM GO:0046331 1/103 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8S4RWM GO:0006974 1/103 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8S4RWM GO:0046872 1/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S4RWM GO:0003676 1/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JT2MQ GO:0016020 22/118 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8JT2MQ GO:0004805 15/118 trehalose-phosphatase activity molecular_function "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] EOG8JT2MQ GO:0005992 15/118 trehalose biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] EOG8JT2MQ GO:0007179 1/118 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8JT2MQ GO:0003700 1/118 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8JT2MQ GO:0005667 1/118 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8JT2MQ GO:0006351 1/118 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8JT2MQ GO:0005634 1/118 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86HJR0 GO:0005549 11/53 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG86HJR0 GO:0005576 1/53 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QJV4S GO:0042302 18/47 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8QJV4S GO:0008010 1/47 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8QJV4S GO:0032504 1/47 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8QJV4S GO:0031012 1/47 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8QJV4S GO:0040003 1/47 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8QJV4S GO:0005615 1/47 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8M0HHH GO:0005737 18/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8M0HHH GO:0030145 18/89 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG8M0HHH GO:0016462 18/89 pyrophosphatase activity molecular_function "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] EOG8M0HHH GO:0016787 3/89 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8M0HHH GO:0050909 1/89 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8M0HHH GO:0016021 1/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M0HHH GO:0019889 1/89 pteridine metabolic process biological_process "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732] EOG8M0HHH GO:0005886 1/89 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8M0HHH GO:0048072 1/89 compound eye pigmentation biological_process "Establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG8R7XR8 GO:0005509 3/106 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8R7XR8 GO:0007394 1/106 dorsal closure, elongation of leading edge cells biological_process "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] EOG8R7XR8 GO:0007422 1/106 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8R7XR8 GO:0035262 1/106 gonad morphogenesis biological_process "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] EOG8R7XR8 GO:0035071 1/106 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8R7XR8 GO:0035297 1/106 regulation of Malpighian tubule diameter biological_process "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] EOG8R7XR8 GO:0048102 1/106 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8R7XR8 GO:0048567 1/106 ectodermal digestive tract morphogenesis biological_process "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] EOG8R7XR8 GO:0007390 1/106 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8R7XR8 GO:0046328 1/106 regulation of JNK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8R7XR8 GO:0004559 1/106 alpha-mannosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] EOG8R7XR8 GO:0007442 1/106 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG8R7XR8 GO:0002009 1/106 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8R7XR8 GO:0008360 1/106 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8R7XR8 GO:0046329 1/106 negative regulation of JNK cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8R7XR8 GO:0007443 1/106 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8R7XR8 GO:0005975 1/106 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8R7XR8 GO:0007435 1/106 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8R7XR8 GO:0008406 1/106 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8R7XR8 GO:0008104 1/106 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8R7XR8 GO:0007391 1/106 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8R7XR8 GO:0007417 1/106 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG898XGP GO:0008201 1/22 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG898XGP GO:0046914 1/22 transition metal ion binding molecular_function "Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] EOG870WXS GO:0016491 43/81 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG870WXS GO:0008336 4/81 gamma-butyrobetaine dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031] EOG870WXS GO:0051213 1/81 dioxygenase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] EOG8V45NQ GO:0006457 68/221 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8V45NQ GO:0005524 68/221 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V45NQ GO:0006950 67/221 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8V45NQ GO:0005737 7/221 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8V45NQ GO:0005811 2/221 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8V45NQ GO:0005515 2/221 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8V45NQ GO:0019094 1/221 pole plasm mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8V45NQ GO:0007283 1/221 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8V45NQ GO:0007052 1/221 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8V45NQ GO:0008595 1/221 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8V45NQ GO:0048471 1/221 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8V45NQ GO:0008293 1/221 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8V45NQ GO:0008285 1/221 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8V45NQ GO:0009408 1/221 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8V45NQ GO:0005615 1/221 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8V45NQ GO:0008360 1/221 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8V45NQ GO:0005705 1/221 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8V45NQ GO:0045187 1/221 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG8V45NQ GO:0009631 1/221 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG8V45NQ GO:0061031 1/221 endodermal digestive tract morphogenesis biological_process "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf] EOG8V45NQ GO:0051082 1/221 unfolded protein binding molecular_function "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] EOG8V45NQ GO:0048477 1/221 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8V45NQ GO:0007015 1/221 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8V45NQ GO:0005813 1/221 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8V45NQ GO:0010529 1/221 negative regulation of transposition biological_process "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] EOG8V45NQ GO:0007494 1/221 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8V45NQ GO:0007098 1/221 centrosome cycle biological_process "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] EOG898XGG GO:0006888 24/78 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG898XGG GO:0016021 24/78 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG898XGG GO:0000139 24/78 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG898XGG GO:0005801 24/78 cis-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] EOG898XGG GO:0015031 22/78 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG898XGG GO:0016192 1/78 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG898XGG GO:0000138 1/78 Golgi trans cisterna cellular_component "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] EOG898XGG GO:0005484 1/78 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG898XGG GO:0006891 1/78 intra-Golgi vesicle-mediated transport biological_process "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] EOG873S7X GO:0008137 1/77 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG873S7X GO:0003954 1/77 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8JT2M3 GO:0000166 71/254 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8JT2M3 GO:0003676 65/254 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JT2M3 GO:0030529 4/254 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8JT2M3 GO:0019013 3/254 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8JT2M3 GO:0005737 2/254 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JT2M3 GO:0003729 2/254 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8JT2M3 GO:0042078 1/254 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG8JT2M3 GO:0017148 1/254 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8JT2M3 GO:0048024 1/254 regulation of mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] EOG8JT2M3 GO:0003697 1/254 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG8JT2M3 GO:0003727 1/254 single-stranded RNA binding molecular_function "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] EOG8JT2M3 GO:0046331 1/254 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8JT2M3 GO:0007298 1/254 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8JT2M3 GO:0000900 1/254 translation repressor activity, nucleic acid binding molecular_function "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw] EOG8JT2M3 GO:0007411 1/254 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8JT2M3 GO:0003723 1/254 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8JT2M3 GO:0048864 1/254 stem cell development biological_process "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] EOG8JT2M3 GO:0045182 1/254 translation regulator activity molecular_function "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] EOG8JT2M3 GO:0043234 1/254 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8JT2M3 GO:0022416 1/254 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8JT2M3 GO:0005844 1/254 polysome cellular_component "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871] EOG8JT2M3 GO:0005634 1/254 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JT2M3 GO:0045727 1/254 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG8JT2M3 GO:0008266 1/254 poly(U) RNA binding molecular_function "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] EOG8JT2M3 GO:0003730 1/254 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8JT2M3 GO:0071456 1/254 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8JT2M3 GO:0006417 1/254 regulation of translation biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8JT2M3 GO:0019827 1/254 stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] EOG8JT2M3 GO:0005654 1/254 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8JT2M3 GO:0048027 1/254 mRNA 5'-UTR binding molecular_function "Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid] EOG8JT2M3 GO:0007319 1/254 negative regulation of oskar mRNA translation biological_process "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] EOG8JT2M3 GO:0001709 1/254 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8JT2M3 GO:0045451 1/254 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8JT2M3 GO:0005515 1/254 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SBHCW GO:0016301 1/55 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8G4K50 GO:0005506 29/76 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8G4K50 GO:0020037 29/76 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8G4K50 GO:0016705 27/76 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8G4K50 GO:0004497 26/76 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8G4K50 GO:0070330 2/76 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8G4K50 GO:0005789 1/76 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG886BVX GO:0003729 28/83 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG886BVX GO:0005634 1/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG886BVX GO:0005515 1/83 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG886BVX GO:0007275 1/83 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG886BVX GO:0006398 1/83 histone mRNA 3'-end processing biological_process "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah] EOG886BVX GO:0005737 1/83 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG886BVX GO:0035613 1/83 RNA stem-loop binding molecular_function "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] EOG8SBHCG GO:0008270 27/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SBHCG GO:0016740 2/93 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8SBHCG GO:0046329 1/93 negative regulation of JNK cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8SBHCG GO:0031252 1/93 cell leading edge cellular_component "The area of a motile cell closest to the direction of movement." [GOC:pg] EOG8SBHCG GO:0007475 1/93 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG8SBHCG GO:0009880 1/93 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8SBHCG GO:0008258 1/93 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8SBHCG GO:0007391 1/93 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8SBHCD GO:0016757 26/102 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SBHCD GO:0046872 1/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SBHCD GO:0003676 1/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B8MTS GO:0003676 55/199 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B8MTS GO:0008270 42/199 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B8MTS GO:0046872 14/199 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8B8MTS GO:0045944 1/199 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8B8MTS GO:0008594 1/199 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8B8MTS GO:0008407 1/199 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8B8MTS GO:0016360 1/199 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG8B8MTS GO:0005700 1/199 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8B8MTS GO:0007423 1/199 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8B8MTS GO:0007411 1/199 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8B8MTS GO:0048666 1/199 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8B8MTS GO:0007601 1/199 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8B8MTS GO:0007219 1/199 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8B8MTS GO:0042051 1/199 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG8B8MTS GO:0007422 1/199 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8B8MTS GO:0043066 1/199 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8B8MTS GO:0043565 1/199 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8B8MTS GO:0006366 1/199 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8B8MTS GO:0003705 1/199 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8B8MTS GO:0003700 1/199 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8B8MTS GO:0048813 1/199 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8B8MTS GO:0045465 1/199 R8 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] EOG8B8MTS GO:0000122 1/199 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8B8MTS GO:0005634 1/199 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8B8MTS GO:0043425 1/199 bHLH transcription factor binding molecular_function "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] EOG8SBHCN GO:0005622 94/418 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8SBHCN GO:0005215 94/418 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8SBHCN GO:0046872 2/418 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SBHCN GO:0003676 2/418 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SBHCN GO:0046331 1/418 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8SBHCN GO:0016918 1/418 retinal binding molecular_function "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [CHEBI:15035, GOC:curators, ISBN:0198506732] EOG8SBHCN GO:0016787 1/418 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8SBHC3 GO:0016853 1/71 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG85XB9C GO:0016491 19/49 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG85XB9C GO:0005829 1/49 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG85XB9C GO:0030586 1/49 [methionine synthase] reductase activity molecular_function "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] EOG85XB9C GO:0016709 1/49 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG886BV8 GO:0005615 1/103 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG886BV8 GO:0070891 1/103 lipoteichoic acid binding molecular_function "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680] EOG886BV8 GO:0030882 1/103 lipid antigen binding molecular_function "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461] EOG886BV8 GO:0055092 1/103 sterol homeostasis biological_process "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl] EOG886BV8 GO:0001530 1/103 lipopolysaccharide binding molecular_function "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] EOG886BV8 GO:0045456 1/103 ecdysteroid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] EOG886BV8 GO:0008039 1/103 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG886BV8 GO:0042834 1/103 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG886BV8 GO:0015918 1/103 sterol transport biological_process "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] EOG886BV8 GO:0061057 1/103 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG8284FH GO:0007165 43/170 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8284FH GO:0000159 43/170 protein phosphatase type 2A complex cellular_component "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] EOG8284FH GO:0008601 43/170 protein phosphatase type 2A regulator activity molecular_function "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai] EOG8284FH GO:0008270 3/170 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8284FH GO:0005634 3/170 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8284FH GO:0003676 3/170 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8284FH GO:0006914 2/170 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8284FH GO:0043066 1/170 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8284FH GO:0051726 1/170 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8284FH GO:0051225 1/170 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8284FH GO:0070328 1/170 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8284FH GO:0007059 1/170 chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] EOG8284FH GO:0007528 1/170 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8284FH GO:0008340 1/170 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8284FH GO:0007274 1/170 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8284FH GO:0006470 1/170 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8284FH GO:0046872 1/170 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8284FH GO:0050790 1/170 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8G4K5V GO:0005887 1/75 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81G5MZ GO:0016021 2/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81G5MZ GO:0004930 2/13 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG847J8D GO:0005549 1/8 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG847J8D GO:0005886 1/8 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG847J8D GO:0004930 1/8 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG847J8D GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG847J8D GO:0004984 1/8 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8R7XRX GO:0016020 1/21 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8577Q2 GO:0016272 24/76 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8577Q2 GO:0006457 24/76 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8GF610 GO:0001539 1/2 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG8GF610 GO:0005198 1/2 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8GF610 GO:0003774 1/2 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8GF610 GO:0009288 1/2 bacterial-type flagellum cellular_component "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] EOG847J8Q GO:0006364 24/71 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG847J8Q GO:0006379 24/71 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG847J8Q GO:0003723 24/71 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG847J8Q GO:0000172 24/71 ribonuclease MRP complex cellular_component "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] EOG847J8Q GO:0008033 22/71 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG847J8Q GO:0004540 21/71 ribonuclease activity molecular_function "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] EOG847J8Q GO:0030677 13/71 ribonuclease P complex cellular_component "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] EOG847J8Q GO:0005655 11/71 nucleolar ribonuclease P complex cellular_component "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] EOG847J8Q GO:0004526 3/71 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG847J8Q GO:0001682 2/71 tRNA 5'-leader removal biological_process "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] EOG847J8Q GO:0003677 1/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8R7XRH GO:0048067 1/35 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG8R7XRH GO:0005576 1/35 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8R7XRH GO:0016853 1/35 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8R7XRH GO:0042438 1/35 melanin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] EOG873S78 GO:0005509 2/17 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8R7XRC GO:0005524 49/160 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R7XRC GO:0004674 46/160 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8R7XRC GO:0004672 2/160 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8R7XRC GO:0004708 2/160 MAP kinase kinase activity molecular_function "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684] EOG8R7XRC GO:0004702 2/160 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8R7XRC GO:0048082 2/160 regulation of adult chitin-containing cuticle pigmentation biological_process "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] EOG8R7XRC GO:0006468 2/160 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8R7XRC GO:0007257 1/160 activation of JUN kinase activity biological_process "The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf] EOG8R7XRC GO:0040018 1/160 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8R7XRC GO:0023014 1/160 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8R7XRC GO:0000187 1/160 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG8R7XRC GO:0007314 1/160 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8R7XRC GO:0045793 1/160 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8R7XRC GO:0005737 1/160 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8R7XRC GO:0007309 1/160 oocyte axis specification biological_process "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8R7XRC GO:0000165 1/160 MAPK cascade biological_process "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] EOG8R7XRC GO:0048666 1/160 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8R7XRC GO:0002385 1/160 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8R7XRC GO:0048812 1/160 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8R7XRC GO:0030424 1/160 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8R7XRC GO:0001934 1/160 positive regulation of protein phosphorylation biological_process "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] EOG8R7XRC GO:0004697 1/160 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8R7XRC GO:0046330 1/160 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8R7XRC GO:0031435 1/160 mitogen-activated protein kinase kinase kinase binding molecular_function "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] EOG8R7XRC GO:0008545 1/160 JUN kinase kinase activity molecular_function "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] EOG8X6FQM GO:0051920 68/238 peroxiredoxin activity molecular_function "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] EOG8X6FQM GO:0016209 57/238 antioxidant activity molecular_function "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] EOG8X6FQM GO:0004601 11/238 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8X6FQM GO:0042744 3/238 hydrogen peroxide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] EOG8X6FQM GO:0008379 3/238 thioredoxin peroxidase activity molecular_function "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] EOG8X6FQM GO:0045454 2/238 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8X6FQM GO:0006974 2/238 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8X6FQM GO:0005829 2/238 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8X6FQM GO:0005515 2/238 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8X6FQM GO:0008340 2/238 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8X6FQM GO:0008354 1/238 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8X6FQM GO:0005576 1/238 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8X6FQM GO:0007281 1/238 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8X6FQM GO:0007155 1/238 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8X6FQM GO:0043066 1/238 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8X6FQM GO:0005875 1/238 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8X6FQM GO:0042594 1/238 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8X6FQM GO:0005783 1/238 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8X6FQM GO:0006979 1/238 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8X6FQM GO:0006909 1/238 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8X6FQM GO:0005739 1/238 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8X6FQM GO:0097190 1/238 apoptotic signaling pathway biological_process "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] EOG8CRPGH GO:0005622 9/25 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8CRPGH GO:0005085 9/25 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8CRPGH GO:0007264 9/25 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8DZ4B4 GO:0006457 25/80 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8DZ4B4 GO:0016272 25/80 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8DZ4B2 GO:0006412 26/93 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8DZ4B2 GO:0005840 26/93 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8DZ4B2 GO:0003735 26/93 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8DZ4B2 GO:0007052 1/93 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8DZ4B2 GO:0000022 1/93 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8DZ4B2 GO:0051298 1/93 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8GB9M3 GO:0035556 14/47 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8GB9M3 GO:0005089 14/47 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8GB9M3 GO:0003676 1/47 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9M3 GO:0015074 1/47 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80KBDJ GO:0008270 11/85 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80KBDJ GO:0003676 10/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80KBDJ GO:0004190 2/85 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG80KBDJ GO:0015074 1/85 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80KBDJ GO:0003964 1/85 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG80KBDJ GO:0003723 1/85 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8ZCWMT GO:0008137 37/99 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8ZCWMT GO:0042773 37/99 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8ZCWMT GO:0005743 37/99 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8Z655V GO:0043565 4/23 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z655V GO:0003700 4/23 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z655V GO:0005634 1/23 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZCWMV GO:0003677 1/17 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C2KS5 GO:0004672 12/35 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8C2KS5 GO:0005524 12/35 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GB9MZ GO:0050660 281/974 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8GB9MZ GO:0008812 249/974 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8GB9MZ GO:0006066 249/974 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8GB9MZ GO:0016614 32/974 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8GB9MZ GO:0004198 12/974 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8GB9MZ GO:0005622 12/974 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8GB9MZ GO:0004344 11/974 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG8GB9MZ GO:0005509 10/974 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GB9MZ GO:0016491 9/974 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GB9MZ GO:0045455 9/974 ecdysteroid metabolic process biological_process "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] EOG8GB9MZ GO:0008270 1/974 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GB9MZ GO:0006915 1/974 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8GB9MZ GO:0042600 1/974 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8GB9MZ GO:0004190 1/974 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8GB9MZ GO:0003676 1/974 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9MZ GO:0004197 1/974 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8GB9MZ GO:0046331 1/974 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8GB9MZ GO:0015074 1/974 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8TQPSG GO:0005509 1/13 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TQPSG GO:0007156 1/13 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8TQPSG GO:0016020 1/13 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZCWM0 GO:0008076 30/110 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8ZCWM0 GO:0005249 30/110 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8ZCWM0 GO:0051260 26/110 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8ZCWM0 GO:0008345 1/110 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8ZCWM0 GO:0060025 1/110 regulation of synaptic activity biological_process "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] EOG8ZCWM0 GO:0048675 1/110 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8ZCWM0 GO:0016021 1/110 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZCWM0 GO:0045187 1/110 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG8ZCWM0 GO:0030431 1/110 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8ZCWM0 GO:0048150 1/110 behavioral response to ether biological_process "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid] EOG8ZCWM0 GO:0048047 1/110 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8ZCWM0 GO:0009584 1/110 detection of visible light biological_process "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8ZCWM0 GO:0007637 1/110 proboscis extension reflex biological_process "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] EOG8ZCWM0 GO:0050909 1/110 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8ZCWM0 GO:0001508 1/110 action potential biological_process "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] EOG8ZCWM0 GO:0007619 1/110 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8ZCWM0 GO:0022843 1/110 voltage-gated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8ZCWM0 GO:0005251 1/110 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8ZCWM0 GO:0007611 1/110 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8ZCWM0 GO:0007629 1/110 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8ZCWM0 GO:0006813 1/110 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8M945K GO:0050660 36/104 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8M945K GO:0008812 33/104 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8M945K GO:0006066 33/104 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8M945K GO:0016614 4/104 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8M945K GO:0004344 3/104 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG8M945K GO:0016491 2/104 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8M945K GO:0045455 2/104 ecdysteroid metabolic process biological_process "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] EOG8M945K GO:0007498 1/104 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8SXQVH GO:0016021 8/54 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SXQVH GO:0004930 8/54 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8SXQVH GO:0007218 1/54 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8SXQVH GO:0050254 1/54 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8GF5WK GO:0003857 19/86 3-hydroxyacyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] EOG8GF5WK GO:0006631 19/86 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG8GF5WK GO:0070403 16/86 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG8GF5WK GO:0008440 6/86 inositol-1,4,5-trisphosphate 3-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023] EOG8GF5WK GO:0050662 3/86 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8GF5WK GO:0052723 1/86 inositol hexakisphosphate 1-kinase activity molecular_function "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] EOG8GF5WK GO:0000832 1/86 inositol hexakisphosphate 5-kinase activity molecular_function "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN] EOG8GF5WK GO:0052724 1/86 inositol hexakisphosphate 3-kinase activity molecular_function "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] EOG8SXQVM GO:0003747 24/79 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG8SXQVM GO:0016740 1/79 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8GF5WG GO:0004930 3/19 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8GF5WG GO:0016021 3/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJZ0B GO:0016020 1/22 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CJZ0B GO:0005024 1/22 transforming growth factor beta-activated receptor activity molecular_function "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] EOG8SXQVS GO:0016021 32/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SXQVS GO:0015031 32/100 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8SXQVS GO:0005789 32/100 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8SXQVS GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SXQVS GO:0006979 1/100 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8SXQVS GO:0008355 1/100 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8SXQVS GO:0007616 1/100 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8SXQVS GO:0045178 1/100 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8SXQVS GO:0008105 1/100 asymmetric protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] EOG8SXQVS GO:0007611 1/100 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8SXQVS GO:0005886 1/100 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8CJZ0M GO:0007275 7/34 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8CJZ0M GO:0016021 7/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJZ0M GO:0007219 7/34 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8GF5WR GO:0009253 197/521 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8GF5WR GO:0008745 196/521 N-acetylmuramoyl-L-alanine amidase activity molecular_function "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] EOG8GF5WR GO:0008270 180/521 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GF5WR GO:0045087 14/521 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8GF5WR GO:0005576 12/521 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GF5WR GO:0042834 11/521 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG8GF5WR GO:0006955 10/521 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8GF5WR GO:0050830 5/521 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8GF5WR GO:0005515 4/521 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GF5WR GO:0061057 3/521 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG8GF5WR GO:0002221 3/521 pattern recognition receptor signaling pathway biological_process "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] EOG8GF5WR GO:0016019 3/521 peptidoglycan receptor activity molecular_function "Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity." [PMID:14698226] EOG8GF5WR GO:0045824 3/521 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8GF5WR GO:0008329 2/521 signaling pattern recognition receptor activity molecular_function "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor] EOG8GF5WR GO:0008340 2/521 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8GF5WR GO:0009617 2/521 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8GF5WR GO:0005887 2/521 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GF5WR GO:0019731 2/521 antibacterial humoral response biological_process "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8GF5WR GO:0006964 1/521 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8GF5WR GO:0042742 1/521 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8GF5WR GO:0044214 1/521 spanning component of plasma membrane cellular_component "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd] EOG8GF5WR GO:0006965 1/521 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] EOG8GF5WR GO:0001875 1/521 lipopolysaccharide receptor activity molecular_function "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] EOG8GF5WR GO:0000270 1/521 peptidoglycan metabolic process biological_process "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8GF5WR GO:0008233 1/521 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8GF5WR GO:0046983 1/521 protein dimerization activity molecular_function "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] EOG8GF5WR GO:0032500 1/521 muramyl dipeptide binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] EOG8GF5WR GO:0008592 1/521 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8GF5WR GO:0051607 1/521 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8GF5WR GO:0031240 1/521 external side of cell outer membrane cellular_component "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] EOG8GF5WR GO:0045089 1/521 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8GF5WR GO:0006963 1/521 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG8GF5WR GO:0008063 1/521 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8GF5WR GO:0016327 1/521 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG8GF5WR GO:0005875 1/521 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8GF5WR GO:0016021 1/521 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GF5WR GO:0007165 1/521 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8GF5WR GO:0031663 1/521 lipopolysaccharide-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975] EOG8GF5WR GO:0006909 1/521 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8GF5WR GO:0004040 1/521 amidase activity molecular_function "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] EOG8GF5WR GO:0032494 1/521 response to peptidoglycan biological_process "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] EOG8GF5WR GO:0050829 1/521 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8GF5WR GO:0035007 1/521 regulation of melanization defense response biological_process "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] EOG8GF5WR GO:0019730 1/521 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8GF5WR GO:0004180 1/521 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8GF5WR GO:0046329 1/521 negative regulation of JNK cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8GF5WR GO:0002920 1/521 regulation of humoral immune response biological_process "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] EOG8GF5WR GO:0061060 1/521 negative regulation of peptidoglycan recognition protein signaling pathway biological_process "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] EOG8M945T GO:0016021 82/190 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M945T GO:0022857 58/190 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8M945T GO:0055085 24/190 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8M945T GO:0005215 10/190 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG88D39Z GO:0006744 32/131 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG88D39Z GO:0008425 32/131 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] EOG88D39Z GO:0008689 2/131 3-demethylubiquinone-9 3-O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] EOG88D39Z GO:0008757 1/131 S-adenosylmethionine-dependent methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] EOG88D39Z GO:0006470 1/131 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG88D39Z GO:0017017 1/131 MAP kinase tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] EOG88D39Z GO:0030798 1/131 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG88D39Z GO:0042060 1/131 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG88D39Z GO:0004395 1/131 hexaprenyldihydroxybenzoate methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] EOG8909S1 GO:0007173 1/74 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8909S1 GO:0005154 1/74 epidermal growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] EOG8909S1 GO:0007298 1/74 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8909S1 GO:0008586 1/74 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8909S1 GO:0005576 1/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8909S1 GO:0007267 1/74 cell-cell signaling biological_process "Any process that mediates the transfer of information from one cell to another." [GOC:mah] EOG8909S1 GO:0007477 1/74 notum development biological_process "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] EOG8909S1 GO:0008284 1/74 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG8909S1 GO:0016203 1/74 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8909S1 GO:0007476 1/74 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8909S1 GO:0007479 1/74 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8909S1 GO:0030031 1/74 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8909S1 GO:0045742 1/74 positive regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8909S1 GO:0008355 1/74 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8909S1 GO:0005515 1/74 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8909S1 GO:0035310 1/74 notum cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] EOG8909S1 GO:0008201 1/74 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8909S1 GO:0007420 1/74 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8909S1 GO:0007494 1/74 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8909S1 GO:0007482 1/74 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8909S1 GO:0007474 1/74 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8909S1 GO:0007422 1/74 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8909S1 GO:0043066 1/74 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG88D3C2 GO:0003700 25/99 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88D3C2 GO:0005634 25/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88D3C2 GO:0043565 24/99 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG88D3C2 GO:0007494 1/99 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG88D3C2 GO:0030154 1/99 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG88D3C2 GO:0046982 1/99 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG88D3C2 GO:0045944 1/99 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG88D3C2 GO:0035284 1/99 brain segmentation biological_process "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] EOG88D3C2 GO:0006366 1/99 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG88D3C2 GO:0000976 1/99 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG88D3C2 GO:0001709 1/99 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG88D3C2 GO:0004000 1/99 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG88D3C2 GO:0007420 1/99 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8MGVQ4 GO:0005576 2/21 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8MGVQ4 GO:0005184 2/21 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8MGVQ4 GO:0045823 2/21 positive regulation of heart contraction biological_process "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] EOG8MGVQ4 GO:0007218 2/21 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8KM1H0 GO:0003676 24/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KM1H0 GO:0005524 24/88 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1H0 GO:0008026 23/88 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8KM1H0 GO:0006200 1/88 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8KM1H0 GO:0008299 1/88 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8KM1H0 GO:0004004 1/88 ATP-dependent RNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] EOG8KM1H0 GO:0004421 1/88 hydroxymethylglutaryl-CoA synthase activity molecular_function "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191] EOG8KM1HG GO:0016747 7/18 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8KM1HG GO:0003824 3/18 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8MGVQJ GO:0051568 1/78 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8MGVQJ GO:0044666 1/78 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8MGVQJ GO:0048188 1/78 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG8MGVQJ GO:0030317 1/78 sperm motility biological_process "Any process involved in the controlled movement of a sperm cell." [GOC:jl] EOG8MGVQJ GO:0046331 1/78 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8MGVQJ GO:0006351 1/78 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8MGVQJ GO:0006355 1/78 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG815JW5 GO:0007165 23/94 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG815JW5 GO:0005622 23/94 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG815JW5 GO:0046961 1/94 proton-transporting ATPase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] EOG815JW5 GO:0033178 1/94 proton-transporting two-sector ATPase complex, catalytic domain cellular_component "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] EOG815JW5 GO:0007480 1/94 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG815JW5 GO:0015991 1/94 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8KM1HT GO:0006096 47/135 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8KM1HT GO:0004739 47/135 pyruvate dehydrogenase (acetyl-transferring) activity molecular_function "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] EOG8KM1HT GO:0043231 46/135 intracellular membrane-bounded organelle cellular_component "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] EOG8KM1HT GO:0016624 3/135 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] EOG8KM1HT GO:0005739 1/135 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG88PQ29 GO:0005634 1/18 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88PQ28 GO:0005887 1/73 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8909SX GO:0003677 2/12 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8909SX GO:0005634 2/12 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZKN3X GO:0007165 1/11 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8ZCWMQ GO:0000723 130/891 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8ZCWMQ GO:0006281 130/891 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8ZCWMQ GO:0003678 130/891 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8ZCWMQ GO:0005524 46/891 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZCWMQ GO:0004386 20/891 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8ZCWMQ GO:0003676 5/891 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZCWMQ GO:0005634 2/891 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZCWMQ GO:0003677 2/891 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZCWMQ GO:0008234 1/891 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8ZCWMQ GO:0006508 1/891 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8ZCWMQ GO:0008270 1/891 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZCWMQ GO:0046872 1/891 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JQ6BG GO:0016021 23/284 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JQ6BG GO:0005216 21/284 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8JQ6BG GO:0005249 4/284 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8JQ6BG GO:0006812 2/284 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8JQ6BG GO:0004692 2/284 cGMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] EOG8JQ6BG GO:0005887 2/284 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JQ6BG GO:0019935 2/284 cyclic-nucleotide-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG8JQ6BG GO:0042391 2/284 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8JQ6BG GO:0005221 2/284 intracellular cyclic nucleotide activated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] EOG8JQ6BG GO:0071805 2/284 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8JQ6BG GO:0017071 2/284 intracellular cyclic nucleotide activated cation channel complex cellular_component "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] EOG8JQ6BG GO:0005223 1/284 intracellular cGMP activated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] EOG8JQ6BG GO:0005222 1/284 intracellular cAMP activated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] EOG8JQ6BG GO:0030553 1/284 cGMP binding molecular_function "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] EOG8JQ6BG GO:0007603 1/284 phototransduction, visible light biological_process "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8JQ6BJ GO:0016021 4/26 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JQ6BJ GO:0005886 4/26 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8JQ6BJ GO:0050909 4/26 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8FXTNH GO:0010891 1/99 negative regulation of sequestering of triglyceride biological_process "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] EOG8FXTNH GO:0010883 1/99 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG8FXTNH GO:0009269 1/99 response to desiccation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] EOG8FXTNH GO:0005975 1/99 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8FXTNH GO:0006629 1/99 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8BCH1X GO:0016021 1/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CZDXB GO:0005975 21/49 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8CZDXB GO:0016757 18/49 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8CZDXB GO:0003945 2/49 N-acetyllactosamine synthase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] EOG8CZDXB GO:0005794 1/49 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8CZDXB GO:0033842 1/49 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] EOG8CZDXB GO:0009247 1/49 glycolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] EOG8CZDXB GO:0008376 1/49 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG8CZDXB GO:0006044 1/49 N-acetylglucosamine metabolic process biological_process "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] EOG8FXTNV GO:0051536 2/6 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8FXTNV GO:0009228 2/6 thiamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] EOG8FXTNV GO:0004789 1/6 thiamine-phosphate diphosphorylase activity molecular_function "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22331] EOG837TVC GO:0005634 2/4 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG837TVC GO:0008270 2/4 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG837TVC GO:0003676 2/4 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HHRJV GO:0030246 2/7 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8THZ9B GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8THZ9B GO:0005230 1/16 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG85F05T GO:0043565 1/21 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85F05T GO:0003700 1/21 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG886BTJ GO:0005524 22/171 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG886BTJ GO:0035091 22/171 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG886BTJ GO:0004672 21/171 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG886BTJ GO:0005635 1/171 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG886BTJ GO:0048477 1/171 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG886BTJ GO:0043234 1/171 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG886BTJ GO:0016772 1/171 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG886BTJ GO:0016301 1/171 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG886BTJ GO:0051445 1/171 regulation of meiotic cell cycle biological_process "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG886BTJ GO:0007346 1/171 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG85F05F GO:0008289 41/142 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG85F05F GO:0005215 41/142 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG85F05F GO:0005875 1/142 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG85F05F GO:0007616 1/142 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG85F05C GO:0005525 15/37 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG85F05C GO:0007264 15/37 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG85F05C GO:0016020 15/37 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85F05C GO:0005622 14/37 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG85F05C GO:0006184 1/37 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8DZ49K GO:0042246 31/108 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8DZ49K GO:0007155 31/108 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8DZ49K GO:0016021 31/108 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GB9MV GO:0005337 31/96 nucleoside transmembrane transporter activity molecular_function "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] EOG8GB9MV GO:0016021 31/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GB9MV GO:0007268 1/96 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8GB9MV GO:0008306 1/96 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG8GB9MV GO:0005886 1/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8GB9MV GO:0090281 1/96 negative regulation of calcium ion import biological_process "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] EOG8WM77M GO:0016787 11/62 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8WM77M GO:0052689 1/62 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG88KTTB GO:0016021 4/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88KTTB GO:0005615 2/84 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8WM77F GO:0048812 1/145 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8WM77F GO:0007156 1/145 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8WM77F GO:0005887 1/145 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WM77F GO:0042802 1/145 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG88KTTR GO:0006334 177/356 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG88KTTR GO:0003677 177/356 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88KTTR GO:0000786 177/356 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG88KTTR GO:0005634 177/356 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G4K4Z GO:0003676 3/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G4K4Z GO:0008270 2/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G4K4Z GO:0005634 2/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G4K4Z GO:0046872 1/10 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81G5JC GO:0008236 2/13 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8G4K4R GO:0016534 28/115 cyclin-dependent protein kinase 5 activator activity molecular_function "Binds to and increases the activity of cyclin-dependent protein kinase 5." [GOC:mah] EOG8G4K4R GO:0016533 28/115 cyclin-dependent protein kinase 5 holoenzyme complex cellular_component "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152] EOG8G4K4R GO:0016301 6/115 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8G4K4R GO:0007409 1/115 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8G4K4R GO:0004693 1/115 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8G4K4R GO:0043025 1/115 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8G4K4R GO:0035011 1/115 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8G4K4R GO:0030426 1/115 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8G4K4R GO:0030424 1/115 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8G4K4R GO:0030425 1/115 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8G4K4R GO:0070059 1/115 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] EOG8G4K4R GO:0008045 1/115 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8G4K4R GO:0008344 1/115 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8G4K4R GO:0071902 1/115 positive regulation of protein serine/threonine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] EOG8G4K4R GO:0008340 1/115 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8JMB4B GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JMB4B GO:0004672 2/10 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8VX4M3 GO:0022008 1/82 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8VX4M3 GO:0004462 1/82 lactoylglutathione lyase activity molecular_function "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072] EOG8VX4M3 GO:0016829 1/82 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8JMB4D GO:0016021 37/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JMB4D GO:0004930 32/124 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8JMB4D GO:0004993 3/124 serotonin receptor activity molecular_function "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] EOG8JMB4D GO:0071928 2/124 tyramine signaling pathway biological_process "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245] EOG8JMB4D GO:0007186 2/124 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8JMB4D GO:0071418 2/124 cellular response to amine stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] EOG8JMB4D GO:0008227 2/124 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8JMB4D GO:0005887 2/124 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JMB4D GO:0008226 1/124 tyramine receptor activity molecular_function "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] EOG8JMB4D GO:0007193 1/124 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8JMB4D GO:1900738 1/124 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G-protein coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] EOG8JMB4D GO:0004715 1/124 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8JMB4D GO:0007211 1/124 octopamine or tyramine signaling pathway biological_process "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] EOG8VX4M0 GO:0008270 76/1021 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VX4M0 GO:0003676 72/1021 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VX4M0 GO:0003964 70/1021 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VX4M0 GO:0015074 70/1021 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8VX4M0 GO:0003723 69/1021 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VX4M0 GO:0005198 14/1021 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8VX4M0 GO:0005882 14/1021 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8VX4M0 GO:0004190 10/1021 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8VX4M0 GO:0003677 4/1021 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4M0 GO:0005634 2/1021 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CJXXC GO:0016021 9/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXXC GO:0005886 9/30 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8CJXXC GO:0050909 9/30 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG88SK90 GO:0004222 5/34 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG88SK90 GO:0008270 5/34 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8JMB4Q GO:0004252 7/21 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8JMB4Q GO:0005581 1/21 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8R7XSV GO:0008270 2/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG847J9M GO:0016301 1/22 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG847J9M GO:0051301 1/22 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG847J9R GO:0007218 20/65 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG847J9R GO:0005615 1/65 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG847J9R GO:0005179 1/65 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG847J9R GO:0010459 1/65 negative regulation of heart rate biological_process "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] EOG847J9R GO:0006942 1/65 regulation of striated muscle contraction biological_process "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] EOG847J9R GO:0008345 1/65 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG847J9R GO:0002209 1/65 behavioral defense response biological_process "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG847J9R GO:0008344 1/65 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG847J9R GO:1900075 1/65 positive regulation of neuromuscular synaptic transmission biological_process "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG847J9R GO:0045822 1/65 negative regulation of heart contraction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] EOG847J9R GO:0071855 1/65 neuropeptide receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] EOG847J9R GO:0005576 1/65 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG847J9S GO:0016301 1/25 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8PG8FN GO:0016884 30/131 carbon-nitrogen ligase activity, with glutamine as amido-N-donor molecular_function "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] EOG8PG8FN GO:0050567 1/131 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG8VQD3H GO:0016787 3/112 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8VQD3H GO:0005634 1/112 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VQD3H GO:0003677 1/112 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VQD37 GO:0042132 28/180 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] EOG8VQD37 GO:0005975 27/180 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8VQD37 GO:0006886 23/180 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8VQD37 GO:0016192 23/180 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8VQD37 GO:0008270 20/180 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VQD37 GO:0006727 1/180 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8VQD37 GO:0035556 1/180 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8VQD37 GO:0006487 1/180 protein N-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] EOG8VQD37 GO:0007041 1/180 lysosomal transport biological_process "The directed movement of substances into, out of or within a lysosome." [GOC:ai] EOG8VQD37 GO:0006897 1/180 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8VQD37 GO:0030897 1/180 HOPS complex cellular_component "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] EOG8VQD37 GO:0008340 1/180 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8VQD37 GO:0016020 1/180 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VQD37 GO:0007220 1/180 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8VQD37 GO:0035542 1/180 regulation of SNARE complex assembly biological_process "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] EOG8VQD37 GO:0033227 1/180 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8VQD37 GO:0003830 1/180 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] EOG8VQD37 GO:0046907 1/180 intracellular transport biological_process "The directed movement of substances within a cell." [GOC:ai] EOG8R7XS7 GO:0008113 31/96 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG8R7XS7 GO:0006979 30/96 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8R7XS7 GO:0030091 30/96 protein repair biological_process "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] EOG8R7XS7 GO:0048812 1/96 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8R7XS7 GO:0048102 1/96 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8R7XS7 GO:0008340 1/96 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8R7XS7 GO:0034599 1/96 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG8R7XS7 GO:0035071 1/96 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8R7XS7 GO:0000096 1/96 sulfur amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] EOG8PG8F4 GO:0016021 1/77 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F7R0M GO:0050909 1/4 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8F7R0M GO:0005886 1/4 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8F7R0M GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV581 GO:0016021 6/66 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV581 GO:0005789 6/66 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8RV581 GO:0033116 6/66 endoplasmic reticulum-Golgi intermediate compartment membrane cellular_component "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730] EOG8RV581 GO:0012507 6/66 ER to Golgi transport vesicle membrane cellular_component "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] EOG847J90 GO:0008270 4/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87M4F8 GO:0046872 7/47 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG87M4F8 GO:0003676 6/47 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FR35F GO:0035220 1/86 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8FR35F GO:0045214 1/86 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8FR35F GO:0048734 1/86 proboscis morphogenesis biological_process "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc] EOG8FR35F GO:0007527 1/86 adult somatic muscle development biological_process "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8FR35F GO:0004725 1/86 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8FR35F GO:0048802 1/86 notum morphogenesis biological_process "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] EOG87Q0KV GO:0016021 10/29 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87Q0KV GO:0008527 10/29 taste receptor activity molecular_function "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] EOG87Q0KV GO:0005886 1/29 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PP112 GO:0005509 1/8 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG87Q0KT GO:0004222 16/41 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG85HVCR GO:0004252 60/114 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG85HVCR GO:0006508 2/114 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG85HVCR GO:0006281 1/114 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG85HVCR GO:0005634 1/114 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JMB48 GO:0044237 25/89 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8JMB48 GO:0050662 25/89 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8JMB48 GO:0003824 22/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8JMB48 GO:0048040 2/89 UDP-glucuronate decarboxylase activity molecular_function "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23919] EOG8JMB48 GO:0008460 1/89 dTDP-glucose 4,6-dehydratase activity molecular_function "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224] EOG8JMB48 GO:0003676 1/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JMB48 GO:0000166 1/89 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8RJJFP GO:0005234 64/194 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RJJFP GO:0016020 63/194 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RJJFP GO:0004970 63/194 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8RJJFP GO:0034220 3/194 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8RJJFP GO:0036081 3/194 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8RJJFP GO:0016021 3/194 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RJJFP GO:0015276 2/194 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RJJFP GO:0050907 1/194 detection of chemical stimulus involved in sensory perception biological_process "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG8RJJFP GO:0005215 1/194 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8RJJFP GO:0009593 1/194 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8RJJFP GO:0050911 1/194 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG8RJJFQ GO:0006355 23/92 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RJJFQ GO:0003677 23/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RJJFQ GO:0005681 21/92 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8RJJFQ GO:0006397 20/92 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8RJJFQ GO:0008380 20/92 RNA splicing biological_process "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] EOG8RJJFQ GO:0005634 2/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RJJFQ GO:0071011 1/92 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8RJJFQ GO:0003676 1/92 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RJJFQ GO:0000398 1/92 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8RJJFQ GO:0071013 1/92 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8RJJFQ GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JMB40 GO:0005634 32/118 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JMB40 GO:0006281 32/118 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8JMB40 GO:0008081 31/118 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG8JMB40 GO:0007417 1/118 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8JMB40 GO:0017005 1/118 3'-tyrosyl-DNA phosphodiesterase activity molecular_function "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265] EOG8JMB40 GO:0004527 1/118 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8JMB40 GO:0005737 1/118 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JMB40 GO:0017119 1/118 Golgi transport complex cellular_component "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] EOG8JMB40 GO:0006886 1/118 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8JMB40 GO:0045197 1/118 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8WDGTF GO:0003700 40/149 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8WDGTF GO:0005634 40/149 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGTF GO:0043565 33/149 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8WDGTF GO:0000976 6/149 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8WDGTF GO:0000980 1/149 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG8WDGTF GO:0001700 1/149 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8WDGTF GO:0014019 1/149 neuroblast development biological_process "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] EOG8WDGTF GO:0010468 1/149 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8WDGTF GO:0007420 1/149 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8WDGTF GO:0048813 1/149 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8WDGTF GO:0007419 1/149 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8WDGTF GO:0035284 1/149 brain segmentation biological_process "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] EOG8WDGTF GO:0007389 1/149 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8WDGTF GO:0035288 1/149 anterior head segmentation biological_process "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] EOG8WDGTF GO:0001158 1/149 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8WDGTF GO:0003677 1/149 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8WDGTF GO:0007409 1/149 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8WDGTF GO:0007424 1/149 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8WDGTF GO:0035277 1/149 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8WDGTG GO:0006974 1/83 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8XPSXS GO:0006457 31/96 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8XPSXS GO:0000774 31/96 adenyl-nucleotide exchange factor activity molecular_function "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] EOG8XPSXS GO:0005759 28/96 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8XPSXS GO:0016853 1/96 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8XPSXS GO:0004750 1/96 ribulose-phosphate 3-epimerase activity molecular_function "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13680] EOG8XPSXS GO:0022008 1/96 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C2KRQ GO:0005549 3/46 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG81K1T5 GO:0051287 73/226 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG81K1T5 GO:0016616 67/226 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG81K1T5 GO:0030267 4/226 glyoxylate reductase (NADP) activity molecular_function "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] EOG81K1T5 GO:0047964 2/226 glyoxylate reductase activity molecular_function "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] EOG81K1T5 GO:0004617 1/226 phosphoglycerate dehydrogenase activity molecular_function "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] EOG81K1T5 GO:0005576 1/226 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81K1T5 GO:0048037 1/226 cofactor binding molecular_function "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] EOG81K1T5 GO:0003676 1/226 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84QWHN GO:0008270 9/22 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84QWHN GO:0016491 1/22 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8WHC14 GO:0005975 86/174 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WHC14 GO:0004568 85/174 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8WHC14 GO:0006032 84/174 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WHC14 GO:0005576 10/174 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8WHC14 GO:0007444 9/174 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8WHC14 GO:0008084 9/174 imaginal disc growth factor receptor binding molecular_function "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah] EOG8WHC14 GO:0007275 1/174 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8WHC14 GO:0006036 1/174 cuticle chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] EOG8WHC14 GO:0005615 1/174 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8WHC14 GO:0008061 1/174 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WHC14 GO:0004553 1/174 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8M945X GO:0004970 15/52 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8M945X GO:0005234 15/52 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8M945X GO:0016021 8/52 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M945X GO:0016020 8/52 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M945X GO:0005215 3/52 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8M945X GO:0015276 1/52 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8M945X GO:0050907 1/52 detection of chemical stimulus involved in sensory perception biological_process "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG8M945X GO:0036081 1/52 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8M945X GO:0034220 1/52 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8GF5VT GO:0003676 5/20 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GF5VT GO:0008270 4/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GF5VT GO:0005634 4/20 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GF5VT GO:0046872 1/20 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81K1TV GO:0015918 4/343 sterol transport biological_process "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] EOG81K1TV GO:0001530 1/343 lipopolysaccharide binding molecular_function "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] EOG81K1TV GO:0030882 1/343 lipid antigen binding molecular_function "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461] EOG81K1TV GO:0008270 1/343 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1TV GO:0022008 1/343 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG81K1TV GO:0005615 1/343 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG81K1TV GO:0070891 1/343 lipoteichoic acid binding molecular_function "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680] EOG81K1TV GO:0061057 1/343 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG81K1TV GO:0042834 1/343 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG8NP9HM GO:0006904 24/108 vesicle docking involved in exocytosis biological_process "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] EOG8NP9HM GO:0016020 2/108 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NP9HM GO:0005737 2/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NP9HM GO:0016192 1/108 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8NP9HM GO:0000149 1/108 SNARE binding molecular_function "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] EOG8NP9HM GO:0006909 1/108 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8NP9HM GO:0048190 1/108 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8NP9HM GO:0022008 1/108 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8NP9HM GO:0000902 1/108 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG81K1TZ GO:0016740 9/88 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81K1TZ GO:0006633 9/88 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG81K1TZ GO:0016021 9/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJZ0H GO:0008033 18/41 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8CJZ0H GO:0004540 18/41 ribonuclease activity molecular_function "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] EOG898XDM GO:0016021 2/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG898XDM GO:0005549 1/34 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG898XDM GO:0004930 1/34 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG898XDM GO:0004984 1/34 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG898XDM GO:0005886 1/34 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MGVPJ GO:0003676 23/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MGVPJ GO:0004527 20/88 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8MGVPJ GO:0008859 1/88 exoribonuclease II activity molecular_function "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] EOG8WSZQM GO:0016021 181/562 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WSZQM GO:0015116 160/562 sulfate transmembrane transporter activity molecular_function "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] EOG8WSZQM GO:0008271 20/562 secondary active sulfate transmembrane transporter activity molecular_function "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] EOG8WSZQM GO:0055085 1/562 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8WSZQM GO:0045434 1/562 negative regulation of female receptivity, post-mating biological_process "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] EOG8MGVPB GO:0030170 33/110 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8MGVPB GO:0006520 30/110 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8MGVPB GO:0016829 26/110 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8MGVPB GO:0004793 4/110 threonine aldolase activity molecular_function "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] EOG8MGVPB GO:0003824 3/110 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81C9BM GO:0016616 1/68 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG81C9BM GO:0051287 1/68 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG81C9BM GO:0000287 1/68 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG82Z762 GO:0016021 1/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81C9BN GO:0004364 2/39 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG81C9BN GO:0016740 1/39 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81C9BN GO:0006749 1/39 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG8909RZ GO:0003735 27/107 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8909RZ GO:0005840 27/107 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8909RZ GO:0006412 27/107 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8909RZ GO:0000022 2/107 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8909RZ GO:0007052 2/107 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG89628M GO:0005525 2/19 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8GJ242 GO:0004252 4/22 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8JQ6CX GO:0003677 5/35 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89GNWR GO:0016779 4/45 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG89GNWR GO:0016740 1/45 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8JQ6CD GO:0007156 2/20 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8JQ6CD GO:0005509 2/20 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8JQ6CD GO:0005886 1/20 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8JQ6CD GO:0016020 1/20 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPD1 GO:0005509 18/84 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8CRPD1 GO:0005615 1/84 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8CRPD1 GO:0009986 1/84 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8CRPD1 GO:0000902 1/84 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8CRPD1 GO:0016021 1/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPD1 GO:0010378 1/84 temperature compensation of the circadian clock biological_process "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] EOG8CRPD1 GO:0005515 1/84 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CRPD1 GO:0031513 1/84 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8CRPD1 GO:0005201 1/84 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8CRPD1 GO:0005576 1/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CRPD1 GO:0042052 1/84 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8909RK GO:0005549 1/26 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG89GNWD GO:0007156 23/117 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG89GNWD GO:0005509 23/117 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG89GNWD GO:0016021 22/117 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89GNWD GO:0005886 22/117 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89GNWD GO:0004022 1/117 alcohol dehydrogenase (NAD) activity molecular_function "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] EOG89GNWD GO:0005887 1/117 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89GNWD GO:0016339 1/117 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG8RBSZQ GO:0005840 34/187 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8RBSZQ GO:0006412 34/187 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8RBSZQ GO:0003735 34/187 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8RBSZQ GO:0046872 23/187 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RBSZQ GO:0003676 18/187 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RBSZQ GO:0005524 6/187 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RBSZQ GO:0006457 5/187 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8RBSZQ GO:0005737 2/187 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RBSZQ GO:0042274 1/187 ribosomal small subunit biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] EOG8RBSZQ GO:0006955 1/187 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8RBSZQ GO:0022627 1/187 cytosolic small ribosomal subunit cellular_component "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] EOG8RBSZQ GO:0044267 1/187 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG8RBSZQ GO:0000022 1/187 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8RBSZQ GO:0007052 1/187 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8RBSZQ GO:0051298 1/187 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8RBSZQ GO:0006364 1/187 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8RBSZV GO:0005524 31/210 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RBSZV GO:0007018 31/210 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8RBSZV GO:0005871 31/210 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8RBSZV GO:0003777 31/210 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8RBSZV GO:0005874 30/210 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8RBSZV GO:0005249 21/210 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8RBSZV GO:0016021 17/210 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RBSZV GO:0016020 3/210 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RBSZV GO:0004871 2/210 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8RBSZV GO:0005819 1/210 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8RBSZV GO:0007422 1/210 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8RBSZV GO:0030496 1/210 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8RBSZV GO:0042391 1/210 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8RBSZV GO:0001709 1/210 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8RBSZV GO:0022008 1/210 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8RBSZV GO:0007605 1/210 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8RBSZV GO:0035323 1/210 male germline ring canal cellular_component "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420] EOG8RBSZV GO:0098549 1/210 somatic ring canal cellular_component "A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects." [GOC:dos, PMID:22135360, PMID:670316] EOG8RBSZV GO:0005828 1/210 kinetochore microtubule cellular_component "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] EOG8RBSZV GO:0070507 1/210 regulation of microtubule cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8RBSZV GO:0007525 1/210 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8RBSZV GO:0035324 1/210 female germline ring canal cellular_component "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420] EOG8RBSZV GO:0008152 1/210 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8RBSZV GO:0032507 1/210 maintenance of protein location in cell biological_process "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] EOG8RBSZV GO:0000916 1/210 actomyosin contractile ring contraction biological_process "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] EOG8RBSZV GO:0007224 1/210 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG8RBSZV GO:0005813 1/210 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8RBSZV GO:0070938 1/210 contractile ring cellular_component "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] EOG8RBSZV GO:0032154 1/210 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8RBSZV GO:0008076 1/210 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8RBSZV GO:0000281 1/210 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8RBSZV GO:0005634 1/210 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RBSZV GO:0051298 1/210 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8RBSZV GO:0006813 1/210 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8RBSZV GO:0016321 1/210 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8RBSZV GO:0000915 1/210 actomyosin contractile ring assembly biological_process "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] EOG8RBSZV GO:0005930 1/210 axoneme cellular_component "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] EOG8RBSZV GO:0071805 1/210 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8RBSZV GO:0051533 1/210 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8RBSZV GO:0030111 1/210 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8RBSZV GO:0007052 1/210 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8JQ6CJ GO:0006030 35/74 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8JQ6CJ GO:0008061 35/74 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8JQ6CJ GO:0005576 35/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8X6FPD GO:0020037 75/249 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8X6FPD GO:0004601 75/249 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8X6FPD GO:0006979 74/249 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8X6FPD GO:0042600 2/249 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8X6FPD GO:0042744 1/249 hydrogen peroxide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] EOG8X6FPD GO:0008270 1/249 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X6FPD GO:0022008 1/249 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8X6FPD GO:0046872 1/249 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X6FPD GO:0007306 1/249 eggshell chorion assembly biological_process "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8X6FPD GO:0005576 1/249 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8X6FPD GO:0006909 1/249 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8STVMX GO:0043565 28/91 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8STVMX GO:0005622 27/91 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8STVMX GO:0004402 1/91 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8STVMX GO:0006338 1/91 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8STVMX GO:0005671 1/91 Ada2/Gcn5/Ada3 transcription activator complex cellular_component "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] EOG8STVMX GO:0003887 1/91 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8STVMX GO:0046982 1/91 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8STVMX GO:0006974 1/91 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8STVMX GO:0042766 1/91 nucleosome mobilization biological_process "The movement of nucleosomes along a DNA fragment." [PMID:12006495] EOG8STVMX GO:0016573 1/91 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8STVMX GO:0008623 1/91 CHRAC cellular_component "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192] EOG8STVMX GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG886BTH GO:0016021 56/247 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BTH GO:0055085 55/247 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG886BTH GO:0005743 55/247 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG886BTH GO:0005215 54/247 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG886BTH GO:0031532 24/247 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG886BTH GO:0007155 24/247 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG886BTH GO:0005811 2/247 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG886BTH GO:0009612 1/247 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG886BTH GO:0034599 1/247 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG886BTH GO:0007268 1/247 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG886BTH GO:0040011 1/247 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG886BTH GO:0051480 1/247 cytosolic calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph] EOG886BTH GO:0007475 1/247 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG886BTH GO:0015866 1/247 ADP transport biological_process "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG886BTH GO:0005471 1/247 ATP:ADP antiporter activity molecular_function "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] EOG886BTH GO:0005925 1/247 focal adhesion cellular_component "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] EOG886BTH GO:0051560 1/247 mitochondrial calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] EOG886BTH GO:0006839 1/247 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG886BTH GO:0008340 1/247 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG886BTH GO:0015867 1/247 ATP transport biological_process "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG886BTH GO:0007629 1/247 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG886BTH GO:0070050 1/247 neuron cellular homeostasis biological_process "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] EOG886BTH GO:0048489 1/247 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG886BTH GO:0016203 1/247 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG886BTH GO:0003779 1/247 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG886BTH GO:0051124 1/247 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG886BTH GO:0001508 1/247 action potential biological_process "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] EOG886BTH GO:0046716 1/247 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8909R7 GO:0005524 41/133 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8909R7 GO:0005737 27/133 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8909R7 GO:0006436 27/133 tryptophanyl-tRNA aminoacylation biological_process "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8909R7 GO:0004830 27/133 tryptophan-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] EOG8909R7 GO:0017111 3/133 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8909R7 GO:0003993 2/133 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8CRPDJ GO:0003676 26/107 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CRPDJ GO:0000166 26/107 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CRPDJ GO:0005848 1/107 mRNA cleavage stimulating factor complex cellular_component "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] EOG8CRPDJ GO:0022008 1/107 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CRPDJ GO:0016491 1/107 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8CRPDJ GO:0003729 1/107 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8CRPDJ GO:0006379 1/107 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG8CRPDJ GO:0016301 1/107 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8CRPDJ GO:0010181 1/107 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8909R3 GO:0005249 2/37 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8909R3 GO:0051260 2/37 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8909R3 GO:0008076 2/37 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG87SVWG GO:0004930 3/19 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG87SVWG GO:0016021 3/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87SVWG GO:0050254 1/19 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG87SVWF GO:0016433 24/72 rRNA (adenine) methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [EC:2.1.1.-] EOG8X6FPS GO:0017187 23/74 peptidyl-glutamic acid carboxylation biological_process "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] EOG8X6FPS GO:0008488 23/74 gamma-glutamyl carboxylase activity molecular_function "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194] EOG8X6FPS GO:0018214 1/74 protein carboxylation biological_process "The addition of a carboxy group to a protein amino acid." [GOC:ai] EOG8X6FPP GO:0004657 30/95 proline dehydrogenase activity molecular_function "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] EOG8X6FPP GO:0006562 30/95 proline catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8X6FPP GO:0006537 29/95 glutamate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] EOG8X6FPP GO:0007626 1/95 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8X6FPP GO:0005759 1/95 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8X6FPP GO:0042331 1/95 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8X6FPP GO:0010133 1/95 proline catabolic process to glutamate biological_process "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] EOG8X6FPP GO:0005739 1/95 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8X6FPP GO:0071949 1/95 FAD binding molecular_function "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] EOG8XWJGB GO:0000166 4/7 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8XWJGB GO:0003676 3/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X6FPX GO:0003824 177/787 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8X6FPX GO:0047077 20/787 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity molecular_function "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] EOG8X6FPX GO:0016874 19/787 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8X6FPX GO:0004497 7/787 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8X6FPX GO:0008756 4/787 o-succinylbenzoate-CoA ligase activity molecular_function "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] EOG8X6FPX GO:0004467 2/787 long-chain fatty acid-CoA ligase activity molecular_function "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3] EOG8X6FPX GO:0005524 2/787 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FPX GO:0006637 1/787 acyl-CoA metabolic process biological_process "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] EOG8X6FPX GO:0046627 1/787 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8X6FPX GO:0046949 1/787 fatty-acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] EOG8X6FPX GO:0005777 1/787 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8X6FPX GO:0019433 1/787 triglyceride catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] EOG8X6FPX GO:0001676 1/787 long-chain fatty acid metabolic process biological_process "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] EOG8X6FPX GO:0004321 1/787 fatty-acyl-CoA synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] EOG8X6FPX GO:0071616 1/787 acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] EOG8X6FPX GO:0016021 1/787 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X6FPX GO:0042626 1/787 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0009062 1/787 fatty acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] EOG8X6FPX GO:0016887 1/787 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0008218 1/787 bioluminescence biological_process "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] EOG8FXTQ5 GO:0005525 42/125 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8FXTQ5 GO:0007264 42/125 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8FXTQ5 GO:0015031 37/125 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8FXTQ5 GO:0045202 2/125 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8FXTQ5 GO:0055037 2/125 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG8FXTQ5 GO:0004767 2/125 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8FXTQ5 GO:0006184 1/125 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8FXTQ5 GO:0005769 1/125 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8FXTQ5 GO:0007422 1/125 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8FXTQ5 GO:0036313 1/125 phosphatidylinositol 3-kinase catalytic subunit binding molecular_function "Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214] EOG8FXTQ5 GO:0003924 1/125 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8FXTQ5 GO:0005515 1/125 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FXTQ5 GO:0030866 1/125 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTQ9 GO:0003677 343/539 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FXTQ9 GO:0000786 343/539 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8FXTQ9 GO:0005634 343/539 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FXTQ9 GO:0006334 343/539 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8FXTQ9 GO:0005811 111/539 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8FXTQ9 GO:0005515 23/539 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8MGVP3 GO:0008270 14/476 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MGVP3 GO:0003676 4/476 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FJBS3 GO:0003676 72/1100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FJBS3 GO:0003964 71/1100 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8FJBS3 GO:0004523 69/1100 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8FJBS3 GO:0003723 34/1100 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FJBS3 GO:0008270 8/1100 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FJBS3 GO:0004519 1/1100 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8FJBS3 GO:0004842 1/1100 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8X3KFR GO:0006351 34/94 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8X3KFR GO:0005634 34/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X3KFR GO:0007275 32/94 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8X3KFR GO:0003700 31/94 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X3KFR GO:0043565 30/94 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8X3KFR GO:0003677 3/94 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X3KFR GO:0006355 3/94 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8X3KFR GO:0000122 2/94 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8X3KFR GO:0048749 2/94 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8X3KFR GO:0001654 1/94 eye development biological_process "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] EOG8X3KFR GO:0007435 1/94 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8X3KFR GO:0007477 1/94 notum development biological_process "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] EOG8X3KFR GO:0001745 1/94 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8X3KFR GO:0035214 1/94 eye-antennal disc development biological_process "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8X3KFR GO:0007469 1/94 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG8X3KFR GO:0000977 1/94 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG8DZ48W GO:0017017 24/121 MAP kinase tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] EOG8DZ48W GO:0004725 19/121 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8DZ48W GO:0006470 7/121 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8DZ48W GO:0008138 2/121 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8DZ48W GO:0043409 1/121 negative regulation of MAPK cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] EOG8DZ48W GO:0016791 1/121 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8DZ48W GO:0002385 1/121 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8DZ48W GO:0005737 1/121 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DZ48W GO:0042127 1/121 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8DZ48W GO:0007428 1/121 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8DZ48W GO:0016337 1/121 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG8DZ48W GO:0035160 1/121 maintenance of epithelial integrity, open tracheal system biological_process "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] EOG8DZ48W GO:0007474 1/121 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8DZ48R GO:0005975 38/107 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8DZ48R GO:0006032 38/107 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8DZ48R GO:0004568 38/107 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8DZ48R GO:0008061 26/107 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8DZ48R GO:0005576 25/107 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8DZ48R GO:0005615 1/107 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8BZQKM GO:0003964 7/71 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BZQKM GO:0004519 6/71 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8BZQKM GO:0003723 2/71 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8JHFZ3 GO:0008270 3/50 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8JHFZ3 GO:0006886 3/50 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8JHFZ3 GO:0006888 3/50 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG8JHFZ3 GO:0030127 3/50 COPII vesicle coat cellular_component "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] EOG8P5NSH GO:0003677 1/24 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P5NSH GO:0043565 1/24 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8P5NSH GO:0003700 1/24 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8WM78K GO:0005975 2/30 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WM78K GO:0004568 1/30 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8WM78K GO:0004553 1/30 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8WM78K GO:0006032 1/30 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82586J GO:0005089 29/101 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG82586J GO:0046928 1/101 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG82586J GO:0035011 1/101 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG82586J GO:0007480 1/101 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG82586J GO:0031594 1/101 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG82586J GO:0016740 1/101 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG85B3WR GO:0005578 4/23 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG85B3WR GO:0008237 4/23 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG85B3WR GO:0008270 4/23 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WM78W GO:0007099 2/20 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG8WM78W GO:0010457 2/20 centriole-centriole cohesion biological_process "The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] EOG82RGN8 GO:0005506 11/48 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG82RGN8 GO:0020037 11/48 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG82RGN8 GO:0016705 11/48 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG82RGN8 GO:0004497 10/48 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG84J50K GO:0003824 10/53 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG84J50K GO:0016787 6/53 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG84J50K GO:0033961 1/53 cis-stilbene-oxide hydrolase activity molecular_function "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] EOG8PVRCK GO:0072487 23/79 MSL complex cellular_component "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852] EOG8PVRCK GO:0043984 23/79 histone H4-K16 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl] EOG8PVRCK GO:0005694 1/79 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8PVRCK GO:0000805 1/79 X chromosome cellular_component "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] EOG8PVRCK GO:0031936 1/79 negative regulation of chromatin silencing biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] EOG8PVRCK GO:0046536 1/79 dosage compensation complex cellular_component "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah] EOG8PVRCK GO:0009047 1/79 dosage compensation by hyperactivation of X chromosome biological_process "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] EOG8PVRCK GO:0016457 1/79 dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome biological_process "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl] EOG8PVRCK GO:0003682 1/79 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8PVRCK GO:0007549 1/79 dosage compensation biological_process "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] EOG8PVRCK GO:0005515 1/79 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8PVRCK GO:0016456 1/79 X chromosome located dosage compensation complex, transcription activating cellular_component "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu] EOG8PVRCK GO:0003677 1/79 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Z0DNX GO:0007275 2/27 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8Z0DNX GO:0016021 2/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z0DNX GO:0007154 2/27 cell communication biological_process "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] EOG8PCD93 GO:0005509 5/22 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8PCD93 GO:0005886 5/22 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PCD93 GO:0007156 5/22 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8WM783 GO:0008270 10/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WM783 GO:0003676 1/61 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WM785 GO:0005856 5/44 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8PVRCV GO:0004871 24/95 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8PVRCV GO:0005634 23/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PVRCV GO:0003677 22/95 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8PVRCV GO:0006351 22/95 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8PVRCV GO:0006355 16/95 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8PVRCV GO:0005737 7/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PVRCV GO:0003700 6/95 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8PVRCV GO:0005667 6/95 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8PVRCV GO:0048477 1/95 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8PVRCV GO:0051726 1/95 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8PVRCV GO:0010508 1/95 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8PVRCV GO:0032869 1/95 cellular response to insulin stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] EOG8PVRCV GO:0071456 1/95 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8PVRCV GO:0030308 1/95 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8PVRCV GO:0030334 1/95 regulation of cell migration biological_process "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] EOG8PVRCV GO:0003989 1/95 acetyl-CoA carboxylase activity molecular_function "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] EOG8PVRCV GO:0006974 1/95 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8PVRCV GO:0060438 1/95 trachea development biological_process "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG8PVRCV GO:0045944 1/95 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8PVRCP GO:0003676 30/107 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PVRCP GO:0008270 13/107 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRCP GO:0005634 13/107 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PVRCP GO:0006351 11/107 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8PVRCP GO:0003700 11/107 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8PVRCP GO:0006366 1/107 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8PVRCP GO:0006357 1/107 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8PVRCP GO:0046872 1/107 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PVRCP GO:0048813 1/107 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8PVRCP GO:0000981 1/107 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8DZ480 GO:0004252 7/26 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8DZ489 GO:0000922 70/210 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8DZ489 GO:0005815 68/210 microtubule organizing center cellular_component "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] EOG8DZ489 GO:0000226 41/210 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8DZ489 GO:0007020 29/210 microtubule nucleation biological_process "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] EOG8DZ489 GO:0005875 2/210 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DZ489 GO:0008275 2/210 gamma-tubulin small complex cellular_component "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] EOG8DZ489 GO:0043015 2/210 gamma-tubulin binding molecular_function "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl] EOG8DZ489 GO:0008017 2/210 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8DZ489 GO:0003677 2/210 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DZ489 GO:0007052 2/210 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8DZ489 GO:0007017 2/210 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8DZ489 GO:0051297 2/210 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8DZ489 GO:0005874 2/210 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8DZ489 GO:0003676 2/210 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DZ489 GO:0046872 2/210 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DZ489 GO:0051726 1/210 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8DZ489 GO:0007067 1/210 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8DZ489 GO:0007140 1/210 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8DZ489 GO:0051225 1/210 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8DZ489 GO:0007283 1/210 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8DZ489 GO:0007126 1/210 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8DZ489 GO:0030953 1/210 astral microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] EOG8DZ489 GO:0043147 1/210 meiotic spindle stabilization biological_process "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] EOG8DZ489 GO:0022008 1/210 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8THZ80 GO:0016787 3/145 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8THZ80 GO:0016791 3/145 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8THZ80 GO:0016311 2/145 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8ZPH8V GO:0003676 3/97 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZPH8V GO:0005634 3/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZPH8V GO:0046872 2/97 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZPH8V GO:0008270 2/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZPH8V GO:0004721 1/97 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8ZPH8S GO:0005524 25/108 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPH8S GO:0004674 22/108 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8ZPH8S GO:0017119 15/108 Golgi transport complex cellular_component "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] EOG8ZPH8S GO:0006891 15/108 intra-Golgi vesicle-mediated transport biological_process "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] EOG8ZPH8S GO:0008353 2/108 RNA polymerase II carboxy-terminal domain kinase activity molecular_function "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] EOG8ZPH8S GO:0007290 1/108 spermatid nucleus elongation biological_process "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8ZPH8S GO:0051301 1/108 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8ZPH8S GO:0007275 1/108 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8ZPH8S GO:0000916 1/108 actomyosin contractile ring contraction biological_process "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] EOG8ZPH8S GO:0000398 1/108 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8ZPH8S GO:0015031 1/108 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8ZPH8S GO:0071013 1/108 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8ZPH8S GO:0007111 1/108 meiosis II cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8ZPH8S GO:0004672 1/108 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8ZPH8S GO:0061024 1/108 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8ZPH8S GO:0005794 1/108 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8ZPH8S GO:0007110 1/108 meiosis I cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8ZPH8S GO:0043147 1/108 meiotic spindle stabilization biological_process "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] EOG8ZPH8S GO:0004693 1/108 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8ZPH8S GO:0000139 1/108 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8ZPH8S GO:0007112 1/108 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8ZPH8S GO:0071011 1/108 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8ZPH8S GO:0006468 1/108 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8BCH22 GO:0016758 383/1077 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8BCH22 GO:0030259 14/1077 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG8BCH22 GO:0015020 13/1077 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG8BCH22 GO:0030246 12/1077 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BCH22 GO:0016999 11/1077 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG8BCH22 GO:0016740 3/1077 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8BCH22 GO:0004181 1/1077 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG8BCH22 GO:0008168 1/1077 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8BCH22 GO:0003851 1/1077 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] EOG8BCH22 GO:0008270 1/1077 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BCH22 GO:0003676 1/1077 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BCH22 GO:0002121 1/1077 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8BCH24 GO:0005975 8/20 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8BCH24 GO:0003824 8/20 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG89S8N8 GO:0005741 27/90 mitochondrial outer membrane cellular_component "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] EOG89S8N8 GO:0008308 27/90 voltage-gated anion channel activity molecular_function "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729] EOG89S8N8 GO:0015288 1/90 porin activity molecular_function "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] EOG89S8N8 GO:0007291 1/90 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG89S8N8 GO:0006811 1/90 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89S8N8 GO:0007005 1/90 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG89S8N8 GO:0005856 1/90 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG89S8N8 GO:0046930 1/90 pore complex cellular_component "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] EOG89S8N8 GO:0016006 1/90 Nebenkern cellular_component "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] EOG89S8N8 GO:0007602 1/90 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG89S8N8 GO:0030382 1/90 sperm mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] EOG89S8N8 GO:0005875 1/90 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG89S8N8 GO:0005739 1/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG89S8N8 GO:0005811 1/90 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG88SK8M GO:0009420 1/10 bacterial-type flagellum filament cellular_component "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] EOG88SK8M GO:0005198 1/10 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG88SK8M GO:0001539 1/10 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG88D38R GO:0005524 25/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88D38R GO:0017111 21/89 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG88D38R GO:0016887 1/89 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG88D38W GO:0016788 294/950 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG88D38W GO:0016042 262/950 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG88D38W GO:0006629 148/950 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG88D38W GO:0004806 8/950 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG88D38W GO:0005615 5/950 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG88D38W GO:0032504 5/950 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG88D38W GO:0016298 4/950 lipase activity molecular_function "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] EOG88D38W GO:0030246 1/950 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG88D38W GO:0016787 1/950 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG88D38W GO:0003676 1/950 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88D38W GO:0007586 1/950 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG88D38W GO:0042632 1/950 cholesterol homeostasis biological_process "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] EOG88D38W GO:0006886 1/950 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG88D38W GO:0048812 1/950 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG88D38W GO:0016192 1/950 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG88D38W GO:0005576 1/950 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88D38W GO:0030132 1/950 clathrin coat of coated pit cellular_component "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] EOG88D38W GO:0030130 1/950 clathrin coat of trans-Golgi network vesicle cellular_component "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] EOG88D38W GO:0005198 1/950 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG88D38W GO:0031410 1/950 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG88D38W GO:0070328 1/950 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG88D38W GO:0004771 1/950 sterol esterase activity molecular_function "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] EOG8SFCNG GO:0005525 27/147 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8SFCNG GO:0003924 25/147 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8SFCNG GO:0003743 5/147 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8SFCNG GO:0004781 1/147 sulfate adenylyltransferase (ATP) activity molecular_function "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] EOG8SFCNG GO:0005737 1/147 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SFCNG GO:0017151 1/147 DEAD/H-box RNA helicase binding molecular_function "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl] EOG8SFCNG GO:0006413 1/147 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG89S8NF GO:0003729 27/87 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG89S8NF GO:0006376 27/87 mRNA splice site selection biological_process "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] EOG89S8NF GO:0005685 27/87 U1 snRNP cellular_component "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah] EOG89S8NF GO:0071011 1/87 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG89S8NF GO:0000398 1/87 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8F7R11 GO:0016021 3/229 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F7R11 GO:0006909 3/229 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8F7R11 GO:0042742 2/229 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8F7R11 GO:0005886 1/229 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8F7R11 GO:0006910 1/229 phagocytosis, recognition biological_process "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149] EOG8F7R11 GO:0046331 1/229 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8F7R11 GO:0009986 1/229 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8F7R11 GO:0005615 1/229 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8F7R11 GO:0006898 1/229 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG8F7R11 GO:0005044 1/229 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG8F7R11 GO:0008233 1/229 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8F7R11 GO:0042834 1/229 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG8ZPH84 GO:0003824 20/113 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8ZPH84 GO:0007030 3/113 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8ZPH84 GO:0043001 3/113 Golgi to plasma membrane protein transport biological_process "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] EOG8ZPH84 GO:0016787 2/113 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZPH84 GO:0004300 1/113 enoyl-CoA hydratase activity molecular_function "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] EOG8ZPH84 GO:0003860 1/113 3-hydroxyisobutyryl-CoA hydrolase activity molecular_function "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] EOG8ZPH81 GO:0009072 28/106 aromatic amino acid family metabolic process biological_process "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] EOG8ZPH81 GO:0004334 28/106 fumarylacetoacetase activity molecular_function "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247] EOG8ZPH81 GO:0003723 5/106 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8ZPH81 GO:0008173 5/106 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG8ZPH81 GO:0006396 5/106 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8BCH2Q GO:0016021 1/112 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BCH2Q GO:0003333 1/112 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8BCH2Q GO:0005765 1/112 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG8BCH2Q GO:0015171 1/112 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8ZPH88 GO:0004222 11/65 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8ZPH88 GO:0008270 6/65 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZPH88 GO:0008237 2/65 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8ZPH88 GO:0004190 1/65 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8D81N2 GO:0005525 25/86 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8D81N2 GO:0006184 25/86 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8D81N2 GO:0007264 25/86 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8D81N2 GO:0016020 25/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8D81N2 GO:0004767 2/86 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8R7XT1 GO:0035556 18/60 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG873S5S GO:0005524 3/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG873S5S GO:0005856 3/14 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG873S5S GO:0005737 3/14 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG873S5K GO:0016021 1/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG873S5K GO:0007219 1/27 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG873S5K GO:0045746 1/27 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG873S5K GO:0007423 1/27 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG873S5K GO:0005515 1/27 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG873S5K GO:0030863 1/27 cortical cytoskeleton cellular_component "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] EOG873S5K GO:0008356 1/27 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG873S5K GO:0005737 1/27 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG873S5K GO:0005769 1/27 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG873S5K GO:0005112 1/27 Notch binding molecular_function "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] EOG873S5K GO:0005886 1/27 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG873S5K GO:0045035 1/27 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG873S5K GO:0003007 1/27 heart morphogenesis biological_process "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] EOG873S5K GO:0007422 1/27 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG873S5K GO:0005770 1/27 late endosome cellular_component "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] EOG8R2692 GO:0003964 5/107 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8R2692 GO:0004519 5/107 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8R2692 GO:0005581 3/107 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8R2692 GO:0016021 1/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R2692 GO:0003723 1/107 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8R2692 GO:0016787 1/107 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R2692 GO:0003676 1/107 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R2692 GO:0046872 1/107 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8R2692 GO:0005886 1/107 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8JWXTK GO:0006310 11/62 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8JWXTK GO:0003676 11/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JWXTK GO:0008026 11/62 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8JWXTK GO:0005524 11/62 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M67ZK GO:0005783 2/92 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8M67ZK GO:0046872 1/92 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81G5K1 GO:0020037 134/349 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG81G5K1 GO:0005506 134/349 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG81G5K1 GO:0016705 98/349 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG81G5K1 GO:0004497 92/349 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG81G5K1 GO:0070330 36/349 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG81G5K1 GO:0005789 2/349 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG81G5K1 GO:0009055 1/349 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG81G5K1 GO:0018676 1/349 (S)-limonene 7-monooxygenase activity molecular_function "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23435] EOG81G5K1 GO:0004508 1/349 steroid 17-alpha-monooxygenase activity molecular_function "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] EOG81G5K1 GO:0007423 1/349 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8Q5C5Q GO:0042302 30/139 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8Q5C5Q GO:0005581 1/139 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8R269F GO:0004252 2/9 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG81G5KT GO:0016021 1/87 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81G5KT GO:0005515 1/87 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81G5KT GO:0005886 1/87 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81G5KT GO:0002028 1/87 regulation of sodium ion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] EOG80KBCK GO:0005089 9/44 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG80KBCK GO:0035556 1/44 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8R269C GO:0008146 30/99 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8R269C GO:0016021 30/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R269C GO:0045570 1/99 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG8R269C GO:0008587 1/99 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8R269C GO:0007424 1/99 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8R269C GO:0007428 1/99 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8R269C GO:0008543 1/99 fibroblast growth factor receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] EOG8R269C GO:0003700 1/99 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8R269C GO:0015012 1/99 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG8R269C GO:0022416 1/99 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8R269C GO:0060828 1/99 regulation of canonical Wnt signaling pathway biological_process "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] EOG8R269C GO:0090097 1/99 regulation of decapentaplegic signaling pathway biological_process "Any process that modulates the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb] EOG80KBCM GO:0035556 30/108 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG80KBCM GO:0004435 25/108 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG80KBCM GO:0004871 24/108 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG80KBCM GO:0005509 20/108 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG80KBCM GO:0006629 18/108 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG80KBCM GO:0009395 11/108 phospholipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG80KBCM GO:0008081 4/108 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG80KBCM GO:0030307 1/108 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG80KBCM GO:0007298 1/108 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG80KBCM GO:0032868 1/108 response to insulin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] EOG80KBCM GO:0032065 1/108 cortical protein anchoring biological_process "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] EOG80KBCM GO:0005938 1/108 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG80KBCM GO:0045596 1/108 negative regulation of cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] EOG80KBCM GO:0042059 1/108 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG80KBCM GO:0005543 1/108 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8BP3ST GO:0006535 2/10 cysteine biosynthetic process from serine biological_process "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] EOG8Q5C5D GO:0005739 24/87 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q5C5D GO:0005840 4/87 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8Q5C5D GO:0006412 1/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8Q5C5D GO:0005762 1/87 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8Q5C5D GO:0003735 1/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8Q5C5D GO:0005763 1/87 mitochondrial small ribosomal subunit cellular_component "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] EOG8JWXT7 GO:0007519 1/166 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG8JWXT7 GO:0008307 1/166 structural constituent of muscle molecular_function "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] EOG8JWXT7 GO:0016203 1/166 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8JWXT7 GO:0000794 1/166 condensed nuclear chromosome cellular_component "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] EOG8JWXT7 GO:0007062 1/166 sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194] EOG8JWXT7 GO:0035206 1/166 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8JWXT7 GO:0007522 1/166 visceral muscle development biological_process "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] EOG8JWXT7 GO:0007525 1/166 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8JWXT7 GO:0030018 1/166 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8JWXT7 GO:0003779 1/166 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8JWXT7 GO:0007076 1/166 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8JWXT7 GO:0040011 1/166 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8JWXT7 GO:0007517 1/166 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8JWXT7 GO:0007520 1/166 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8JWXT7 GO:0030017 1/166 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8JWXT7 GO:0045214 1/166 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8JWXT7 GO:0007498 1/166 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8JWXT7 GO:0005875 1/166 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8JWXT7 GO:0016301 1/166 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8R52H1 GO:0005524 5/39 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R52H1 GO:0003777 5/39 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8R52H1 GO:0005871 5/39 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8R52H1 GO:0007018 5/39 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8R52H1 GO:0005874 4/39 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8D81NQ GO:0048190 1/53 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG873S59 GO:0003824 14/96 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG873S52 GO:0050660 110/344 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG873S52 GO:0009055 107/344 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG873S52 GO:0051537 105/344 2 iron, 2 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG873S52 GO:0016614 104/344 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG873S52 GO:0005506 90/344 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG873S52 GO:0046872 23/344 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG873S52 GO:0016491 9/344 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG873S52 GO:0008762 6/344 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG873S52 GO:0051536 2/344 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG873S52 GO:0018492 1/344 carbon-monoxide dehydrogenase (acceptor) activity molecular_function "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] EOG873S52 GO:0007155 1/344 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG873S52 GO:0016020 1/344 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PG8GS GO:0004930 1/10 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8PG8GS GO:0016021 1/10 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PG8GQ GO:0016192 23/103 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8PG8GQ GO:0016021 22/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PG8GN GO:0051647 1/85 nucleus localization biological_process "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8PG8GN GO:0045214 1/85 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8PG8GN GO:0008594 1/85 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8PG8GN GO:0048786 1/85 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8PG8GN GO:0016337 1/85 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG8PG8GN GO:0051643 1/85 endoplasmic reticulum localization biological_process "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8PG8GN GO:0002121 1/85 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8PG8GN GO:0051646 1/85 mitochondrion localization biological_process "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8PG8GN GO:0048788 1/85 cytoskeleton of presynaptic active zone cellular_component "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438] EOG8PG8GN GO:0007286 1/85 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8J6V70 GO:0006334 1/4 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8J6V70 GO:0000786 1/4 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8J6V70 GO:0003677 1/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J6V70 GO:0005634 1/4 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D81NF GO:0046872 1/74 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D81NF GO:0003677 1/74 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8D81NF GO:0006355 1/74 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D81NH GO:0003676 14/76 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D81NH GO:0046872 14/76 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D81NH GO:0008270 13/76 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81NH GO:0022008 1/76 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG880MC4 GO:0007156 1/33 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG880MC4 GO:0016021 1/33 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG880MC4 GO:0005509 1/33 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GJ25Q GO:0003700 1/31 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8GJ25Q GO:0043565 1/31 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8GJ25Q GO:0005634 1/31 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NZX77 GO:0015074 206/1674 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8NZX77 GO:0003964 173/1674 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8NZX77 GO:0003723 170/1674 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NZX77 GO:0003676 151/1674 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NZX77 GO:0008270 67/1674 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NZX77 GO:0004190 64/1674 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8NZX77 GO:0004523 2/1674 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8NZX77 GO:0003677 2/1674 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NZX77 GO:0003899 1/1674 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8NZX77 GO:0043565 1/1674 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NZX77 GO:0005634 1/1674 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NZX77 GO:0003700 1/1674 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NZX77 GO:0004519 1/1674 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8NZX77 GO:0046872 1/1674 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NZX77 GO:0019048 1/1674 modulation by virus of host morphology or physiology biological_process "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945] EOG8NZX77 GO:0019031 1/1674 viral envelope cellular_component "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] EOG8NZX77 GO:0006351 1/1674 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8NZX77 GO:0008233 1/1674 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8HB11D GO:0046872 1/12 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GJ25J GO:0006888 25/68 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG8GJ25J GO:0005622 25/68 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8SXQT1 GO:0015450 24/96 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] EOG8SXQT1 GO:0006886 24/96 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8SXQT1 GO:0005743 23/96 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8SXQT1 GO:0071456 1/96 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8SXQT1 GO:0016787 1/96 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XWJD7 GO:0038032 22/98 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG8XWJD7 GO:0005057 21/98 receptor signaling protein activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] EOG8XWJD7 GO:0030695 15/98 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8XWJD7 GO:0014045 1/98 establishment of endothelial blood-brain barrier biological_process "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] EOG8XWJD7 GO:0008069 1/98 dorsal/ventral axis specification, ovarian follicular epithelium biological_process "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8XWJD7 GO:0009786 1/98 regulation of asymmetric cell division biological_process "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] EOG8XWJD7 GO:0000578 1/98 embryonic axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] EOG8XWJD7 GO:0007186 1/98 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8XWJD7 GO:0008105 1/98 asymmetric protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] EOG8XWJD7 GO:0005096 1/98 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8XWJD7 GO:0005886 1/98 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XWJD7 GO:0045179 1/98 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8XWJD7 GO:0010001 1/98 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8XWJD7 GO:0005515 1/98 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XWJD7 GO:0043547 1/98 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8XWJD7 GO:0007310 1/98 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8XWJD7 GO:0001965 1/98 G-protein alpha-subunit binding molecular_function "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] EOG8XWJD7 GO:0016324 1/98 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8XWJD7 GO:0009408 1/98 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8XWJD7 GO:0005092 1/98 GDP-dissociation inhibitor activity molecular_function "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] EOG8XWJD7 GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XWJD7 GO:0003015 1/98 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG8XWJD7 GO:0060857 1/98 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG8XWJD7 GO:0050790 1/98 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8XWJD7 GO:0007049 1/98 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8XWJD7 GO:0055059 1/98 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8XWJD7 GO:0008277 1/98 regulation of G-protein coupled receptor protein signaling pathway biological_process "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] EOG8XWJD7 GO:0006979 1/98 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8XWJD7 GO:0019991 1/98 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8XWJD7 GO:0050832 1/98 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8XWJD7 GO:0030866 1/98 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8XWJD7 GO:0007419 1/98 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8XWJD7 GO:0032291 1/98 axon ensheathment in central nervous system biological_process "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] EOG8XWJD7 GO:0007303 1/98 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8XWJD7 GO:0042594 1/98 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG86Q97J GO:0016491 34/115 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG86Q97J GO:0032934 25/115 sterol binding molecular_function "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah] EOG86Q97J GO:0047936 1/115 glucose 1-dehydrogenase [NAD(P)] activity molecular_function "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] EOG86Q97J GO:0050038 1/115 L-xylulose reductase (NADP+) activity molecular_function "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17028] EOG86Q97J GO:0005875 1/115 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG86Q97J GO:0033814 1/115 propanoyl-CoA C-acyltransferase activity molecular_function "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] EOG86Q97J GO:0005811 1/115 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG86Q97J GO:0005777 1/115 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG87SVVX GO:0008270 2/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XSP44 GO:0005576 10/25 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP44 GO:0008061 10/25 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP44 GO:0006030 10/25 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87SVVQ GO:0016746 26/80 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG87SVVQ GO:0032048 1/80 cardiolipin metabolic process biological_process "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] EOG87SVVQ GO:0007291 1/80 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG87SVVQ GO:0007006 1/80 mitochondrial membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG87SVVQ GO:0016021 1/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87SVVQ GO:0006644 1/80 phospholipid metabolic process biological_process "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG87SVVQ GO:0032049 1/80 cardiolipin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] EOG87SVVQ GO:0005739 1/80 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG87SVVQ GO:0032577 1/80 phosphatidylcholine:cardiolipin O-linoleoyltransferase activity molecular_function "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] EOG8H48NS GO:0005634 1/9 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8H48NS GO:0008270 1/9 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8W10WC GO:0042302 17/30 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8W10WC GO:0008010 1/30 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8W10WC GO:0031012 1/30 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8W10WC GO:0040003 1/30 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG80S2WJ GO:0016491 161/516 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80S2WJ GO:0004032 11/516 alditol:NADP+ 1-oxidoreductase activity molecular_function "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] EOG80S2WJ GO:0035220 1/516 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG80S2WJ GO:0047006 1/516 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity molecular_function "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] EOG80S2WJ GO:0016319 1/516 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG80S2WJ GO:0008106 1/516 alcohol dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] EOG80S2WJ GO:0022416 1/516 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8C2KQH GO:0005886 7/25 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8C2KQH GO:0016021 7/25 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C2KQH GO:0050909 7/25 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8XSP4J GO:0003676 4/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XSP4J GO:0008270 4/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XSP4J GO:0005634 4/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6GF GO:0000166 26/93 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CC6GF GO:0003676 25/93 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CC6GF GO:0003729 1/93 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8CC6GF GO:0005875 1/93 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8T1M49 GO:0006605 39/99 protein targeting biological_process "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] EOG8T1M49 GO:0015450 39/99 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] EOG8T1M49 GO:0016020 37/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8T1M49 GO:0005789 2/99 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8T1M49 GO:0016021 2/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T1M49 GO:0010507 1/99 negative regulation of autophagy biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8T1M49 GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8D293P GO:0035091 13/80 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG8D293P GO:0038032 12/80 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG86Q976 GO:0003700 74/252 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86Q976 GO:0005634 74/252 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86Q976 GO:0043565 73/252 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG86Q976 GO:0001745 2/252 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG86Q976 GO:0048749 2/252 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG86Q976 GO:0045944 1/252 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86Q976 GO:0007455 1/252 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG86Q976 GO:0001744 1/252 optic lobe placode formation biological_process "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] EOG86Q976 GO:0007623 1/252 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG86Q976 GO:0000976 1/252 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG86Q976 GO:0008406 1/252 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG86Q976 GO:0007503 1/252 fat body development biological_process "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] EOG86Q976 GO:0048812 1/252 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG86Q976 GO:0007283 1/252 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG86Q976 GO:0001751 1/252 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG86Q976 GO:0001746 1/252 Bolwig's organ morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] EOG86Q976 GO:0008347 1/252 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG86Q976 GO:0009649 1/252 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG86Q976 GO:0006366 1/252 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86Q976 GO:0003705 1/252 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG86Q976 GO:0007520 1/252 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG86Q976 GO:0035271 1/252 ring gland development biological_process "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098] EOG86Q976 GO:0007458 1/252 progression of morphogenetic furrow involved in compound eye morphogenesis biological_process "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] EOG86Q976 GO:0008134 1/252 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG86Q976 GO:0007498 1/252 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG86Q976 GO:0048813 1/252 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG86Q976 GO:0005515 1/252 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86Q974 GO:0016021 45/122 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q974 GO:0004930 38/122 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG86Q974 GO:0004983 8/122 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG86Q974 GO:0050254 4/122 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG86Q974 GO:0008188 2/122 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG86Q974 GO:0007186 2/122 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG86Q974 GO:0005887 2/122 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q974 GO:0007218 2/122 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG86Q974 GO:0008261 2/122 allatostatin receptor activity molecular_function "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] EOG86Q974 GO:0005840 1/122 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8XWJDD GO:0016021 70/167 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJDG GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GJ255 GO:0033897 31/97 ribonuclease T2 activity molecular_function "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1] EOG8GJ255 GO:0003723 31/97 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GJ255 GO:0032504 1/97 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8GJ255 GO:0090501 1/97 RNA phosphodiester bond hydrolysis biological_process "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG8GJ255 GO:0006401 1/97 RNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] EOG8GJ255 GO:0004540 1/97 ribonuclease activity molecular_function "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] EOG8GJ255 GO:0005615 1/97 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8NS5RG GO:0004503 2/265 monophenol monooxygenase activity molecular_function "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136] EOG8NS5RG GO:0008045 1/265 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8NS5RG GO:0016201 1/265 synaptic target inhibition biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] EOG8NS5RG GO:0005811 1/265 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8NS5RG GO:0046872 1/265 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NS5RG GO:0005616 1/265 larval serum protein complex cellular_component "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] EOG8NS5RG GO:0045735 1/265 nutrient reservoir activity molecular_function "Functions in the storage of nutritious substrates." [GOC:ai] EOG8NS5RG GO:0016491 1/265 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8SR0BM GO:0005634 28/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SR0BM GO:0003707 26/104 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8SR0BM GO:0043565 22/104 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8SR0BM GO:0008270 22/104 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR0BM GO:0006351 19/104 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SR0BM GO:0003700 19/104 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SR0BM GO:0004879 8/104 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8SR0BM GO:0003677 6/104 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SR0BM GO:0048842 1/104 positive regulation of axon extension involved in axon guidance biological_process "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] EOG8SR0BM GO:0030522 1/104 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG8SR0BM GO:0031103 1/104 axon regeneration biological_process "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] EOG8SR0BM GO:0020037 1/104 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8SR0BM GO:0022008 1/104 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SR0BM GO:0007411 1/104 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SR0BM GO:0016322 1/104 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8SR0BM GO:0048526 1/104 imaginal disc-derived wing expansion biological_process "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] EOG8SR0BM GO:0016319 1/104 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8SR0BM GO:0004887 1/104 thyroid hormone receptor activity molecular_function "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling] EOG8SR0BK GO:0005741 40/123 mitochondrial outer membrane cellular_component "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] EOG8SR0BK GO:0055085 38/123 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8SR0BK GO:0006811 2/123 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8SR0BK GO:0006626 2/123 protein targeting to mitochondrion biological_process "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] EOG8SR0BK GO:0015288 2/123 porin activity molecular_function "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] EOG8SR0BK GO:0046930 2/123 pore complex cellular_component "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] EOG8SR0BK GO:0042719 1/123 mitochondrial intermembrane space protein transporter complex cellular_component "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] EOG8SR0BK GO:0071456 1/123 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8SR0BK GO:0005739 1/123 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG88PQ0W GO:0006633 27/107 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG88PQ0W GO:0016705 27/107 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG88PQ0W GO:0016021 27/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88PQ0W GO:0006629 4/107 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG88PQ0W GO:0016006 1/107 Nebenkern cellular_component "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] EOG88PQ0W GO:0042284 1/107 sphingolipid delta-4 desaturase activity molecular_function "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141] EOG88PQ0W GO:0007053 1/107 spindle assembly involved in male meiosis biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] EOG88PQ0W GO:0070938 1/107 contractile ring cellular_component "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] EOG88PQ0W GO:0005886 1/107 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88PQ0W GO:0005739 1/107 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG88PQ0W GO:0007283 1/107 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG88PQ0W GO:0004768 1/107 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG88PQ0V GO:0016021 2/14 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88PQ0V GO:0005230 2/14 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8QC3KT GO:0006914 27/90 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8QC3KT GO:0050829 1/90 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8QC3KT GO:0035071 1/90 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8QC3KT GO:0030097 1/90 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8QC3KT GO:0045824 1/90 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8QC3KT GO:0009306 1/90 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG8QC3KT GO:0006897 1/90 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8QC3KT GO:0006979 1/90 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8QC3KT GO:0048102 1/90 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8SR0BB GO:0016021 2/24 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SR0BB GO:0004930 1/24 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8P2SG7 GO:0005267 23/95 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8P2SG7 GO:0016021 23/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88PQ0M GO:0035556 24/111 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG88PQ0M GO:0046872 24/111 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88PQ0M GO:0005089 23/111 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG88PQ0M GO:0016477 1/111 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG88PQ0M GO:0016740 1/111 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG88PQ0M GO:0004697 1/111 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG88PQ0M GO:0072499 1/111 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG88PQ0M GO:0007015 1/111 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG88PQ0M GO:0032314 1/111 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG88PQ0M GO:0007520 1/111 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG88PQ0M GO:0007391 1/111 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG88PQ0M GO:0007411 1/111 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG88PQ0M GO:0007417 1/111 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG88PQ0M GO:0031532 1/111 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG88PQ0M GO:0032863 1/111 activation of GTPase activity biological_process "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] EOG88PQ0M GO:0030676 1/111 Rac guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG88PQ0M GO:0007155 1/111 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG88PQ0M GO:0007409 1/111 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG88PQ0M GO:0007424 1/111 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG88PQ0M GO:0035011 1/111 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG88PQ0M GO:0008360 1/111 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8S7N55 GO:0003824 1/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S7N57 GO:0016559 21/64 peroxisome fission biological_process "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] EOG8S7N57 GO:0005779 21/64 integral component of peroxisomal membrane cellular_component "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] EOG8S7N57 GO:0007031 1/64 peroxisome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] EOG8Z0DMK GO:0006914 26/78 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8Z0DMK GO:0015031 26/78 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8Z0DMK GO:0005737 25/78 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z0DMK GO:0005829 1/78 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QC3KD GO:0005737 1/120 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QC3KD GO:0005543 1/120 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8003ZR GO:0046872 25/81 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FXTP0 GO:0035267 28/86 NuA4 histone acetyltransferase complex cellular_component "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] EOG8FXTP0 GO:0006338 28/86 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8FXTP0 GO:0043967 28/86 histone H4 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] EOG8FXTP0 GO:0043968 28/86 histone H2A acetylation biological_process "The modification of histone H2A by the addition of an acetyl group." [GOC:jl] EOG8FXTP0 GO:0006281 28/86 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8FXTP0 GO:0045892 28/86 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8FXTP0 GO:0003682 15/86 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8FXTP0 GO:0008168 3/86 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8FXTP0 GO:0006909 1/86 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8P5NQB GO:0016020 20/138 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG889719 GO:0005524 280/803 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG889719 GO:0016021 278/803 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG889719 GO:0042626 272/803 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008559 6/803 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG889719 GO:0032440 5/803 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG889719 GO:0003676 2/803 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG889719 GO:0016887 2/803 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008270 2/803 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG889719 GO:0042060 1/803 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG889719 GO:0000776 1/803 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG889719 GO:0048190 1/803 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG889719 GO:0006200 1/803 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG889719 GO:0034508 1/803 centromere complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] EOG889719 GO:0046688 1/803 response to copper ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] EOG889719 GO:0034059 1/803 response to anoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] EOG889719 GO:0046331 1/803 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG889719 GO:0007275 1/803 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG889719 GO:0010043 1/803 response to zinc ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] EOG889719 GO:0031427 1/803 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG889719 GO:0001666 1/803 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG889719 GO:0043492 1/803 ATPase activity, coupled to movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] EOG8003ZG GO:0043565 20/88 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8003ZG GO:0003700 19/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8003ZG GO:0046872 6/88 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8003ZG GO:0003676 2/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8003ZG GO:0005634 2/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8003ZG GO:0010866 1/88 regulation of triglyceride biosynthetic process biological_process "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] EOG8003ZG GO:0002385 1/88 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8003ZG GO:0031453 1/88 positive regulation of heterochromatin assembly biological_process "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] EOG8003ZG GO:0031618 1/88 nuclear pericentric heterochromatin cellular_component "Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993] EOG8003ZG GO:0051403 1/88 stress-activated MAPK cascade biological_process "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] EOG8003ZG GO:0045944 1/88 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8003ZG GO:0005701 1/88 polytene chromosome chromocenter cellular_component "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] EOG8003ZG GO:0009651 1/88 response to salt stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] EOG8003ZG GO:0005509 1/88 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8003ZG GO:0070829 1/88 heterochromatin maintenance biological_process "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] EOG8003ZG GO:0001077 1/88 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8003ZG GO:0042803 1/88 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8003ZG GO:0034605 1/88 cellular response to heat biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] EOG8003ZG GO:0005704 1/88 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG8003ZG GO:0030431 1/88 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8003ZG GO:0071470 1/88 cellular response to osmotic stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] EOG8SR09N GO:0003676 2/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SR09N GO:0008270 1/19 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR09N GO:0046872 1/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FJBRF GO:0042302 572/1336 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8FJBRF GO:0040003 37/1336 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8FJBRF GO:0008010 37/1336 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0031012 37/1336 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8FJBRF GO:0005576 13/1336 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FJBRF GO:0008363 8/1336 larval chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8FJBRF GO:0005215 7/1336 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FJBRF GO:0008011 2/1336 structural constituent of pupal chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0005615 1/1336 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8FJBRF GO:0032504 1/1336 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8FJBRF GO:0042381 1/1336 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG844P0S GO:0003676 1/115 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FJBRD GO:0030554 25/161 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8FJBRD GO:0016301 7/161 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8FJBRD GO:0005634 1/161 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FJBRD GO:0045787 1/161 positive regulation of cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] EOG8FJBRD GO:0006629 1/161 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8FJBRD GO:2001020 1/161 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8FJBRD GO:0005737 1/161 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FJBRD GO:0030730 1/161 sequestering of triglyceride biological_process "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] EOG8FJBRD GO:0042595 1/161 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8FJBRD GO:0009267 1/161 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8FJBRD GO:0006914 1/161 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8FJBRD GO:0042632 1/161 cholesterol homeostasis biological_process "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] EOG8B8MTJ GO:0000166 3/22 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8B8MTJ GO:0003676 3/22 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88971B GO:0005524 59/204 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88971B GO:0004713 35/204 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG88971B GO:0016021 30/204 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88971B GO:0004714 21/204 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG88971B GO:0007169 19/204 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG88971B GO:0016020 13/204 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88971B GO:0004672 4/204 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG88971B GO:0061327 1/204 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG88971B GO:0045087 1/204 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG88971B GO:0007015 1/204 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG88971B GO:0043066 1/204 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG88971B GO:0045610 1/204 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG88971B GO:0007419 1/204 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG88971B GO:0038202 1/204 TORC1 signaling biological_process "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] EOG88971B GO:0008360 1/204 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG88971B GO:0036335 1/204 intestinal stem cell homeostasis biological_process "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] EOG88971B GO:0035099 1/204 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG88971B GO:0019730 1/204 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG88971B GO:0030031 1/204 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG88971B GO:0007443 1/204 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG88971B GO:0048803 1/204 imaginal disc-derived male genitalia morphogenesis biological_process "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] EOG88971B GO:0007298 1/204 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG88971B GO:0007435 1/204 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG88971B GO:0000022 1/204 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG88971B GO:0043410 1/204 positive regulation of MAPK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] EOG88971B GO:0030097 1/204 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG88971B GO:0005886 1/204 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88971B GO:0006468 1/204 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG88971B GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88971B GO:0007516 1/204 hemocyte development biological_process "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG88971B GO:0006974 1/204 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG88971B GO:0018108 1/204 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG88971B GO:0035172 1/204 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG88971B GO:0032869 1/204 cellular response to insulin stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] EOG88971B GO:0030036 1/204 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8B8MTT GO:0019310 25/78 inositol catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators] EOG8B8MTT GO:0005506 25/78 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8B8MTT GO:0005737 25/78 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B8MTT GO:0050113 25/78 inositol oxygenase activity molecular_function "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699] EOG8FXTPN GO:0004935 31/147 adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] EOG8FXTPN GO:0016021 31/147 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FXTPN GO:0004715 3/147 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8FXTPN GO:0005886 1/147 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FXTPN GO:0005840 1/147 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8SR09W GO:0005634 27/143 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SR09W GO:0043704 1/143 photoreceptor cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] EOG8SR09W GO:0016319 1/143 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8SR09W GO:0005515 1/143 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SR09W GO:0007483 1/143 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG8SR09W GO:0042051 1/143 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG8SR09W GO:0035263 1/143 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG8SR09W GO:0010629 1/143 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8SR09W GO:0048749 1/143 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8SR09W GO:0030182 1/143 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8SR09W GO:0007411 1/143 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SR09W GO:0006351 1/143 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SR09W GO:0007479 1/143 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8SR09W GO:0035215 1/143 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8SR09W GO:0035211 1/143 spermathecum morphogenesis biological_process "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] EOG8SR09W GO:0048098 1/143 antennal joint development biological_process "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid] EOG8FXTPJ GO:0008478 26/87 pyridoxal kinase activity molecular_function "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] EOG8FXTPJ GO:0009443 26/87 pyridoxal 5'-phosphate salvage biological_process "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] EOG8K6JN8 GO:0038032 1/10 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG8QC3K8 GO:0030414 2/87 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8QC3K8 GO:0008233 2/87 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG86DPK0 GO:0005634 8/63 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86DPK0 GO:0003700 8/63 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86DPK0 GO:0045927 1/63 positive regulation of growth biological_process "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG86DPK0 GO:0035212 1/63 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG86DPK0 GO:0045893 1/63 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86DPK0 GO:0006351 1/63 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86DPK0 GO:0010506 1/63 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG86DPK0 GO:0008283 1/63 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG86DPK0 GO:0009880 1/63 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG86DPK0 GO:0045746 1/63 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG86DPK0 GO:0008361 1/63 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG86DPK0 GO:0003677 1/63 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86DPK0 GO:0009987 1/63 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG86DPK0 GO:0044719 1/63 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG86DPK0 GO:0022008 1/63 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG86DPK0 GO:0001558 1/63 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG86DPK0 GO:0040018 1/63 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG86DPK0 GO:0030307 1/63 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG86DPK0 GO:0005515 1/63 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86DPK0 GO:0046620 1/63 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG86DPK0 GO:0048639 1/63 positive regulation of developmental growth biological_process "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] EOG86DPK0 GO:0042981 1/63 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG86DPK0 GO:0043234 1/63 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG86DPK0 GO:0006355 1/63 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86DPK0 GO:0042023 1/63 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG86DPK0 GO:0048477 1/63 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG86DPK0 GO:0009792 1/63 embryo development ending in birth or egg hatching biological_process "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG86DPK0 GO:0051726 1/63 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8SR0B3 GO:0003707 25/92 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8SR0B3 GO:0005634 25/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SR0B3 GO:0006351 24/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SR0B3 GO:0003700 24/92 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SR0B3 GO:0008270 23/92 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR0B3 GO:0043565 22/92 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8SR0B3 GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SR0B3 GO:0016321 1/92 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8SR0B3 GO:0035211 1/92 spermathecum morphogenesis biological_process "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] EOG8SR0B3 GO:0030522 1/92 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG8SR0B3 GO:0006919 1/92 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8SR0B3 GO:0060968 1/92 regulation of gene silencing biological_process "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] EOG8SR0B3 GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SR0B3 GO:0045433 1/92 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG8SR0B3 GO:0000978 1/92 RNA polymerase II core promoter proximal region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] EOG8SR0B3 GO:0004879 1/92 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8SR0B3 GO:0035072 1/92 ecdysone-mediated induction of salivary gland cell autophagic cell death biological_process "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] EOG8SR0B2 GO:0016772 23/60 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SFCMW GO:0016021 1/12 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SFCMW GO:0006633 1/12 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8SFCMW GO:0016717 1/12 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG83BQ33 GO:0004177 167/275 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG83BQ33 GO:0005737 163/275 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ33 GO:0030145 163/275 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG83BQ33 GO:0008235 163/275 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG83BQ33 GO:0005622 4/275 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83BQ33 GO:0005615 1/275 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG83BQ33 GO:0003676 1/275 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83BQ33 GO:0032504 1/275 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG83BQ33 GO:0016319 1/275 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG83BQ33 GO:0016706 1/275 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG83BQ33 GO:0007498 1/275 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG83BQ33 GO:0015074 1/275 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG88D39J GO:0031409 3/20 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG88D39J GO:0005576 2/20 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88D39H GO:0016021 1/54 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87WR49 GO:0005634 23/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87WR49 GO:0006351 21/84 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GTNSQ GO:0005524 13/54 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GTNSQ GO:0004713 13/54 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8GTNSQ GO:0016301 2/54 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8GXJ49 GO:0046872 13/71 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GXJ49 GO:0003677 7/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GXJ49 GO:0003676 3/71 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GXJ47 GO:0015031 27/80 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8GXJ47 GO:0046872 27/80 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GXJ47 GO:0005739 26/80 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8GXJ47 GO:0005743 1/80 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8C5G1K GO:0005634 23/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8C5G1K GO:0006260 22/88 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8C5G1K GO:0046331 1/88 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8C5G1K GO:0048477 1/88 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8C5G1K GO:0030261 1/88 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8C5G1K GO:0022008 1/88 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C5G1K GO:0000811 1/88 GINS complex cellular_component "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] EOG8C5G1K GO:0006271 1/88 DNA strand elongation involved in DNA replication biological_process "The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194] EOG8C5G1K GO:1900087 1/88 positive regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8C5G1K GO:0032784 1/88 regulation of DNA-templated transcription, elongation biological_process "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8C5G1K GO:0032508 1/88 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8C5G1K GO:0010468 1/88 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8C5G1K GO:0016021 1/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C5G1K GO:0004930 1/88 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8C5G1K GO:0005777 1/88 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8323CB GO:0005634 1/7 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8323CB GO:0008270 1/7 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8323CB GO:0003676 1/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XD65F GO:0016757 22/102 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8XD65F GO:0016055 4/102 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8XD65F GO:0008120 3/102 ceramide glucosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] EOG8XD65F GO:0005789 1/102 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8XD65F GO:0043066 1/102 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8XD65F GO:0008152 1/102 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8XD65F GO:0000139 1/102 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8BCH3W GO:0010506 1/87 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8BCH3W GO:0006914 1/87 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8BCH3W GO:0034273 1/87 ATG1/UKL1 kinase complex cellular_component "A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598] EOG8BCH3W GO:0005829 1/87 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8BCH3W GO:0000407 1/87 pre-autophagosomal structure cellular_component "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] EOG8N5ZDF GO:0006457 2/40 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8FXTND GO:0046872 5/104 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FXTND GO:0004842 1/104 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8FXTND GO:0000151 1/104 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG8BZQHW GO:0005509 30/90 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8BZQHW GO:0004623 30/90 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG8BZQHW GO:0016042 30/90 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8BZQHW GO:0005576 27/90 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BZQHW GO:0006644 27/90 phospholipid metabolic process biological_process "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8BCH36 GO:0003676 34/97 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BCH36 GO:0004523 31/97 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8BCH36 GO:0000287 9/97 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8BCH36 GO:0090502 1/97 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG8WM79F GO:0005509 13/66 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8WM79F GO:0004571 13/66 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity molecular_function "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] EOG8WM79F GO:0016020 13/66 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84J51S GO:0005509 2/4 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG84J51S GO:0007156 2/4 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG84J51S GO:0016021 2/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84J51S GO:0005886 1/4 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG83BQ3X GO:0007281 1/98 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG83BQ3X GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ3X GO:0019099 1/98 female germ-line sex determination biological_process "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] EOG83BQ3X GO:0018992 1/98 germ-line sex determination biological_process "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] EOG83BQ3X GO:0048134 1/98 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG83BQ3X GO:0051276 1/98 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG83BQ3X GO:0048477 1/98 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG83BQ3X GO:0032877 1/98 positive regulation of DNA endoreduplication biological_process "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] EOG82587M GO:0030246 9/45 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG82587M GO:0008233 1/45 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG88D395 GO:0003700 3/10 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88D395 GO:0005634 3/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88D395 GO:0043565 3/10 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83BQ3N GO:0006950 2/33 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG80ZTFM GO:0007409 1/126 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG80ZTFM GO:0022008 1/126 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82587R GO:0006457 26/86 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG82587R GO:0003755 1/86 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG87WR4P GO:0008355 2/112 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG87WR4P GO:0005783 2/112 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG87WR4P GO:0007298 2/112 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG87WR4P GO:0008284 2/112 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG87WR4P GO:0016318 1/112 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG87WR4P GO:0007438 1/112 oenocyte development biological_process "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] EOG87WR4P GO:0043066 1/112 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG87WR4P GO:0035225 1/112 determination of genital disc primordium biological_process "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] EOG87WR4P GO:0042058 1/112 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG87WR4P GO:0000086 1/112 G2/M transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] EOG87WR4P GO:0046673 1/112 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG87WR4P GO:0016021 1/112 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87WR4P GO:0007432 1/112 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG87WR4P GO:0048149 1/112 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG87WR4P GO:0007421 1/112 stomatogastric nervous system development biological_process "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] EOG87WR4P GO:0003015 1/112 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG87WR4P GO:0005576 1/112 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87WR4P GO:0061331 1/112 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG87WR4P GO:0007422 1/112 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG87WR4P GO:0005789 1/112 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG87WR4P GO:0050769 1/112 positive regulation of neurogenesis biological_process "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] EOG87WR4P GO:0005886 1/112 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87WR4P GO:0000139 1/112 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG87WR4P GO:0048749 1/112 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG87WR4P GO:0045742 1/112 positive regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG87WR4P GO:0046845 1/112 branched duct epithelial cell fate determination, open tracheal system biological_process "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] EOG87WR4P GO:0005515 1/112 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87WR4P GO:0045470 1/112 R8 cell-mediated photoreceptor organization biological_process "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339] EOG87WR4P GO:0022008 1/112 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG87WR4P GO:0016330 1/112 second mitotic wave involved in compound eye morphogenesis biological_process "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] EOG87WR4P GO:0007476 1/112 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG87WR4P GO:0007424 1/112 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG87WR4P GO:0035277 1/112 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG87WR4P GO:0045741 1/112 positive regulation of epidermal growth factor-activated receptor activity biological_process "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] EOG87WR4P GO:0005794 1/112 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG87WR4P GO:0000165 1/112 MAPK cascade biological_process "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] EOG87WR4P GO:0007173 1/112 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG87WR4P GO:0005154 1/112 epidermal growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] EOG87WR4P GO:0048865 1/112 stem cell fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] EOG8VX4K3 GO:0005524 51/166 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VX4K3 GO:0016887 50/166 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8VX4K3 GO:0015438 1/166 teichoic-acid-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40] EOG8VX4K3 GO:0015408 1/166 ferric-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] EOG8VX4K8 GO:0016747 17/20 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8G4K6G GO:0016020 1/44 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80KBDD GO:0003677 16/43 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80KBDD GO:0022008 1/43 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MGVNG GO:0003755 24/87 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8MGVNG GO:0006457 24/87 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8MGVNG GO:0071013 1/87 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8MGVNG GO:0000398 1/87 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG805VF4 GO:0055085 23/108 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG805VF4 GO:0016021 23/108 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R268K GO:0016747 22/101 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8R268K GO:0040003 1/101 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8R268K GO:0030421 1/101 defecation biological_process "The expulsion of feces from the rectum." [GOC:mah] EOG8R268K GO:0048477 1/101 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8R268K GO:0007586 1/101 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8R268K GO:0022600 1/101 digestive system process biological_process "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] EOG805VF0 GO:0016021 70/329 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG805VF0 GO:0022857 41/329 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG805VF0 GO:0055085 29/329 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG805VF0 GO:0005215 13/329 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG805VF0 GO:0008643 1/329 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8R268N GO:0016021 22/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R268N GO:0004930 20/88 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8R268N GO:0004965 2/88 G-protein coupled GABA receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] EOG8R268B GO:0016021 28/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R268B GO:0004930 26/103 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8R268B GO:0008188 1/103 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8R268B GO:0007186 1/103 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8R268B GO:0007218 1/103 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG805VF8 GO:0004252 8/35 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8JT2NK GO:0003998 88/203 acylphosphatase activity molecular_function "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] EOG8JT2NK GO:0008152 5/203 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8JT2NK GO:0005737 2/203 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JT2NK GO:0044237 1/203 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8JT2NK GO:0016787 1/203 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R268X GO:0005230 8/35 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8R268X GO:0005886 7/35 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8R268X GO:0016021 7/35 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R268X GO:0045202 5/35 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8R268X GO:0030054 5/35 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8R268X GO:0016020 1/35 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NW22Z GO:0016021 69/289 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW22Z GO:0004930 45/289 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NW22Z GO:0004935 13/289 adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] EOG8NW22Z GO:0005886 11/289 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NW22Z GO:0004993 7/289 serotonin receptor activity molecular_function "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] EOG8NW22Z GO:0043565 4/289 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NW22Z GO:0004715 4/289 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8NW22Z GO:0003700 4/289 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NW22Z GO:0007186 3/289 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8NW22Z GO:0010579 3/289 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway biological_process "Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] EOG8NW22Z GO:0008227 3/289 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8NW22Z GO:0004989 3/289 octopamine receptor activity molecular_function "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai] EOG8NW22Z GO:0005887 3/289 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW22Z GO:0007189 3/289 adenylate cyclase-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8NW22Z GO:0004977 2/289 melanocortin receptor activity molecular_function "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] EOG8NW22Z GO:0045886 1/289 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8NW22Z GO:0007188 1/289 adenylate cyclase-modulating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] EOG8NW22Z GO:0045887 1/289 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8W3W4V GO:0003676 1/3 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NW22F GO:0007298 1/70 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8NW22F GO:0005634 1/70 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NW22F GO:0005886 1/70 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87Q0MQ GO:0016616 4/47 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG87Q0MQ GO:0044262 3/47 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG87Q0MQ GO:0005975 1/47 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8VX4KS GO:0046872 11/348 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VX4KS GO:0005737 1/348 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VX4KS GO:0010629 1/348 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8VX4KS GO:0042826 1/348 histone deacetylase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] EOG8VX4KS GO:0005634 1/348 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG879HN5 GO:0005506 116/248 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG879HN5 GO:0020037 116/248 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG879HN5 GO:0016705 114/248 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG879HN5 GO:0004497 107/248 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG879HN5 GO:0031966 7/248 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG879HN5 GO:0017085 3/248 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG879HN5 GO:0008386 2/248 cholesterol monooxygenase (side-chain-cleaving) activity molecular_function "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] EOG879HN5 GO:0046680 2/248 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG879HN5 GO:0005739 1/248 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG879HN5 GO:0030342 1/248 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity molecular_function "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] EOG879HN5 GO:0055114 1/248 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG87Q0MJ GO:0016747 2/5 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]