GO:0005179 hormone activity Gains GO:0048018 receptor ligand activity Gains GO:0031409 pigment binding Gains GO:0030545 receptor regulator activity Gains GO:0004803 transposase activity Gains GO:0005184 neuropeptide hormone activity Gains GO:0005214 structural constituent of chitin-based cuticle Gains GO:0042302 structural constituent of cuticle Gains GO:0008010 structural constituent of chitin-based larval cuticle Gains GO:0019206 nucleoside kinase activity Gains GO:0098772 molecular function regulator Gains GO:0004797 thymidine kinase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0019205 nucleobase-containing compound kinase activity Gains GO:0004385 guanylate kinase activity Gains GO:0016504 peptidase activator activity Gains GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Gains GO:0008559 xenobiotic transmembrane transporting ATPase activity Gains GO:0042910 xenobiotic transmembrane transporter activity Gains GO:0019136 deoxynucleoside kinase activity Gains GO:0042043 neurexin family protein binding Gains GO:0033743 peptide-methionine (R)-S-oxide reductase activity Gains GO:0018454 acetoacetyl-CoA reductase activity Gains GO:0061134 peptidase regulator activity Gains GO:0019201 nucleotide kinase activity Gains GO:0003964 RNA-directed DNA polymerase activity Losses GO:0034061 DNA polymerase activity Losses GO:0003676 nucleic acid binding Losses GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0038023 signaling receptor activity Losses GO:0043565 sequence-specific DNA binding Losses GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding Losses GO:0003700 DNA binding transcription factor activity Losses GO:0099600 transmembrane receptor activity Losses GO:0016779 nucleotidyltransferase activity Losses GO:0004871 signal transducer activity Losses GO:0003677 DNA binding Losses GO:1901363 heterocyclic compound binding Losses GO:0004714 transmembrane receptor protein tyrosine kinase activity Losses GO:0097159 organic cyclic compound binding Losses GO:0005452 inorganic anion exchanger activity Losses GO:0140097 catalytic activity, acting on DNA Losses GO:0046914 transition metal ion binding Losses GO:0008270 zinc ion binding Losses GO:0019199 transmembrane receptor protein kinase activity Losses GO:0060089 molecular transducer activity Losses GO:0004872 receptor activity Losses GO:0016772 transferase activity, transferring phosphorus-containing groups Losses GO:0000976 transcription regulatory region sequence-specific DNA binding Losses GO:0140110 transcription regulator activity Losses GO:1990837 sequence-specific double-stranded DNA binding Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0070001 aspartic-type peptidase activity Losses GO:0015103 inorganic anion transmembrane transporter activity Losses GO:0004867 serine-type endopeptidase inhibitor activity Losses GO:0046872 metal ion binding Losses GO:0032947 protein complex scaffold activity Losses GO:0043169 cation binding Losses GO:0004560 alpha-L-fucosidase activity Losses GO:0022833 mechanically gated channel activity Losses GO:0030366 molybdopterin synthase activity Losses GO:0015928 fucosidase activity Losses GO:0008381 mechanically-gated ion channel activity Losses GO:0008475 procollagen-lysine 5-dioxygenase activity Losses GO:0044212 transcription regulatory region DNA binding Losses GO:0015075 ion transmembrane transporter activity Losses GO:0000975 regulatory region DNA binding Losses GO:0001067 regulatory region nucleic acid binding Losses GO:0005509 calcium ion binding Losses GO:0016162 cellulose 1,4-beta-cellobiosidase activity Losses GO:0004620 phospholipase activity Losses GO:0008509 anion transmembrane transporter activity Losses GO:0005261 cation channel activity Losses GO:0005488 binding Losses GO:0046873 metal ion transmembrane transporter activity Losses GO:0015291 secondary active transmembrane transporter activity Losses GO:0004368 glycerol-3-phosphate dehydrogenase activity Losses GO:0015321 sodium-dependent phosphate transmembrane transporter activity Losses GO:0004344 glucose dehydrogenase activity Losses GO:0008241 peptidyl-dipeptidase activity Losses GO:0004430 1-phosphatidylinositol 4-kinase activity Losses GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Losses GO:0008756 o-succinylbenzoate-CoA ligase activity Losses GO:0000340 RNA 7-methylguanosine cap binding Losses GO:0008812 choline dehydrogenase activity Losses GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity Losses GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Losses GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Losses GO:0070815 peptidyl-lysine 5-dioxygenase activity Losses GO:0005078 MAP-kinase scaffold activity Losses GO:0008190 eukaryotic initiation factor 4E binding Losses GO:0016740 transferase activity Losses GO:0022891 substrate-specific transmembrane transporter activity Losses GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Losses GO:0003690 double-stranded DNA binding Losses GO:0022892 substrate-specific transporter activity Losses GO:0022857 transmembrane transporter activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0031369 translation initiation factor binding Losses GO:0035251 UDP-glucosyltransferase activity Losses GO:0004713 protein tyrosine kinase activity Losses GO:0016782 transferase activity, transferring sulfur-containing groups Losses GO:0005216 ion channel activity Losses GO:0001012 RNA polymerase II regulatory region DNA binding Losses GO:0003964 RNA-directed DNA polymerase activity Extinctions GO:0003676 nucleic acid binding Extinctions GO:0030366 molybdopterin synthase activity Extinctions GO:0034061 DNA polymerase activity Extinctions GO:0005452 inorganic anion exchanger activity Extinctions GO:0032947 protein complex scaffold activity Extinctions GO:0016782 transferase activity, transferring sulfur-containing groups Extinctions GO:0140097 catalytic activity, acting on DNA Extinctions GO:0008378 galactosyltransferase activity Extinctions GO:1901363 heterocyclic compound binding Extinctions GO:0016209 antioxidant activity Extinctions GO:0097159 organic cyclic compound binding Extinctions GO:0016779 nucleotidyltransferase activity Extinctions GO:0015438 teichoic-acid-transporting ATPase activity Extinctions GO:0015162 teichoic acid transmembrane transporter activity Extinctions GO:0008747 N-acetylneuraminate lyase activity Extinctions GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity Extinctions GO:0019841 retinol binding Extinctions GO:0045174 glutathione dehydrogenase (ascorbate) activity Extinctions GO:0004734 pyrimidodiazepine synthase activity Extinctions GO:0042979 ornithine decarboxylase regulator activity Extinctions GO:0005504 fatty acid binding Extinctions GO:0008073 ornithine decarboxylase inhibitor activity Extinctions GO:0008022 protein C-terminus binding Extinctions GO:0008919 lipopolysaccharide glucosyltransferase I activity Extinctions GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity Extinctions GO:0031434 mitogen-activated protein kinase kinase binding Extinctions GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity Extinctions GO:0030159 receptor signaling complex scaffold activity Extinctions GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor Extinctions GO:0016648 oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor Extinctions GO:0033041 sweet taste receptor activity Extinctions GO:0016405 CoA-ligase activity Extinctions GO:0004601 peroxidase activity Extinctions GO:0016684 oxidoreductase activity, acting on peroxide as acceptor Extinctions