GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0004984 olfactory receptor activity Gains GO:0005549 odorant binding Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0008270 zinc ion binding Gains GO:0046914 transition metal ion binding Gains GO:0038023 signaling receptor activity Gains GO:0043169 cation binding Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0016779 nucleotidyltransferase activity Gains GO:0046872 metal ion binding Gains GO:0004872 receptor activity Gains GO:0008527 taste receptor activity Gains GO:0003676 nucleic acid binding Gains GO:0004930 G-protein coupled receptor activity Gains GO:0060089 molecular transducer activity Gains GO:0004871 signal transducer activity Gains GO:0008233 peptidase activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0099600 transmembrane receptor activity Gains GO:0005488 binding Gains GO:0008238 exopeptidase activity Gains GO:0004175 endopeptidase activity Gains GO:0004180 carboxypeptidase activity Gains GO:0004869 cysteine-type endopeptidase inhibitor activity Gains GO:0042169 SH2 domain binding Gains GO:1901363 heterocyclic compound binding Gains GO:0003677 DNA binding Gains GO:0097159 organic cyclic compound binding Gains GO:0008235 metalloexopeptidase activity Gains GO:0004435 phosphatidylinositol phospholipase C activity Gains GO:0004629 phospholipase C activity Gains GO:0016405 CoA-ligase activity Gains GO:0000155 phosphorelay sensor kinase activity Gains GO:0042562 hormone binding Gains GO:0004673 protein histidine kinase activity Gains GO:0043167 ion binding Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0004866 endopeptidase inhibitor activity Gains GO:0016775 phosphotransferase activity, nitrogenous group as acceptor Gains GO:0016878 acid-thiol ligase activity Gains GO:0004181 metallocarboxypeptidase activity Gains GO:0016208 AMP binding Gains GO:0043560 insulin receptor substrate binding Gains GO:0043559 insulin binding Gains GO:0008251 tRNA-specific adenosine deaminase activity Gains GO:0005104 fibroblast growth factor receptor binding Gains GO:0004321 fatty-acyl-CoA synthase activity Gains GO:0003720 telomerase activity Gains GO:0003721 telomerase RNA reverse transcriptase activity Gains GO:0008741 ribulokinase activity Gains GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Gains GO:0005550 pheromone binding Gains GO:0070615 nucleosome-dependent ATPase activity Gains GO:0051425 PTB domain binding Gains GO:0005009 insulin-activated receptor activity Gains GO:0008061 chitin binding Gains GO:0061135 endopeptidase regulator activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0005201 extracellular matrix structural constituent Gains GO:0030414 peptidase inhibitor activity Gains GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity Gains GO:0004032 alditol:NADP+ 1-oxidoreductase activity Gains GO:0004033 aldo-keto reductase (NADP) activity Gains GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity Gains GO:0008106 alcohol dehydrogenase (NADP+) activity Gains GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity Gains GO:0004371 glycerone kinase activity Gains GO:0004326 tetrahydrofolylpolyglutamate synthase activity Gains GO:0004463 leukotriene-A4 hydrolase activity Gains GO:0004470 malic enzyme activity Gains GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity Gains GO:0052723 inositol hexakisphosphate 1-kinase activity Gains GO:0052724 inositol hexakisphosphate 3-kinase activity Gains GO:0005520 insulin-like growth factor binding Gains GO:0019788 NEDD8 transferase activity Gains GO:0022833 mechanically gated channel activity Gains GO:0050062 long-chain-fatty-acyl-CoA reductase activity Gains GO:0003997 acyl-CoA oxidase activity Gains GO:0003987 acetate-CoA ligase activity Gains GO:0005080 protein kinase C binding Gains GO:0004649 poly(ADP-ribose) glycohydrolase activity Gains GO:0000828 inositol hexakisphosphate kinase activity Gains GO:0000832 inositol hexakisphosphate 5-kinase activity Gains GO:0008381 mechanically-gated ion channel activity Gains GO:0032033 myosin II light chain binding Gains GO:0004867 serine-type endopeptidase inhibitor activity Gains GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Losses GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding Losses GO:0042302 structural constituent of cuticle Losses GO:0003700 DNA binding transcription factor activity Losses GO:0004736 pyruvate carboxylase activity Losses GO:0005024 transforming growth factor beta-activated receptor activity Losses GO:0004675 transmembrane receptor protein serine/threonine kinase activity Losses GO:0016418 S-acetyltransferase activity Losses GO:0043565 sequence-specific DNA binding Losses GO:0005214 structural constituent of chitin-based cuticle Losses GO:0008241 peptidyl-dipeptidase activity Losses GO:0004075 biotin carboxylase activity Losses GO:0140110 transcription regulator activity Losses GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding Losses GO:0004879 nuclear receptor activity Losses GO:0016840 carbon-nitrogen lyase activity Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0003707 steroid hormone receptor activity Losses GO:0003677 DNA binding Losses GO:0044212 transcription regulatory region DNA binding Losses GO:0001067 regulatory region nucleic acid binding Losses GO:0000975 regulatory region DNA binding Losses GO:0004803 transposase activity Losses GO:0008134 transcription factor binding Losses GO:0004000 adenosine deaminase activity Losses GO:0044877 macromolecular complex binding Losses GO:0004872 receptor activity Losses GO:0032403 protein complex binding Losses GO:0000976 transcription regulatory region sequence-specific DNA binding Losses GO:0038023 signaling receptor activity Losses GO:0008010 structural constituent of chitin-based larval cuticle Losses GO:0043855 cyclic nucleotide-gated ion channel activity Losses GO:0050431 transforming growth factor beta binding Losses GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity Losses GO:0004997 thyrotropin-releasing hormone receptor activity Losses GO:0004946 bombesin receptor activity Losses GO:0050111 mycocerosate synthase activity Losses GO:0009703 nitrate reductase (NADH) activity Losses GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Losses GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Losses GO:0005125 cytokine activity Losses GO:0016815 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Losses GO:0008255 ecdysis-triggering hormone activity Losses GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0004329 formate-tetrahydrofolate ligase activity Losses GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity Losses GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity Losses GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Losses GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity Losses GO:0005221 intracellular cyclic nucleotide activated cation channel activity Losses GO:0005222 intracellular cAMP activated cation channel activity Losses GO:0005223 intracellular cGMP activated cation channel activity Losses GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity Losses GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Losses GO:0042301 phosphate ion binding Losses GO:0004477 methenyltetrahydrofolate cyclohydrolase activity Losses GO:0003873 6-phosphofructo-2-kinase activity Losses GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors Losses GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Losses GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Losses GO:0004796 thromboxane-A synthase activity Losses GO:0001222 transcription corepressor binding Losses GO:0001226 RNA polymerase II transcription corepressor binding Losses GO:0050093 methanol dehydrogenase activity Losses GO:0047880 erythrulose reductase activity Losses GO:0000257 nitrilase activity Losses GO:0016361 activin receptor activity, type I Losses GO:0005025 transforming growth factor beta receptor activity, type I Losses GO:0008940 nitrate reductase activity Losses GO:0070037 rRNA (pseudouridine) methyltransferase activity Losses GO:0047536 2-aminoadipate transaminase activity Losses GO:0042654 ecdysis-triggering hormone receptor activity Losses GO:0004055 argininosuccinate synthase activity Losses GO:0004056 argininosuccinate lyase activity Losses GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016879 ligase activity, forming carbon-nitrogen bonds Losses GO:1990837 sequence-specific double-stranded DNA binding Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0001653 peptide receptor activity Losses GO:0016885 ligase activity, forming carbon-carbon bonds Losses GO:0060089 molecular transducer activity Losses GO:0004871 signal transducer activity Losses GO:0004312 fatty acid synthase activity Losses GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Losses GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Losses GO:0019199 transmembrane receptor protein kinase activity Losses GO:0008227 G-protein coupled amine receptor activity Losses GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Losses GO:0004032 alditol:NADP+ 1-oxidoreductase activity Losses GO:0004033 aldo-keto reductase (NADP) activity Losses GO:0043874 acireductone synthase activity Losses GO:0008443 phosphofructokinase activity Losses GO:0008106 alcohol dehydrogenase (NADP+) activity Losses GO:0016843 amine-lyase activity Losses GO:0016844 strictosidine synthase activity Losses GO:0008271 secondary active sulfate transmembrane transporter activity Losses GO:0004370 glycerol kinase activity Losses GO:0004328 formamidase activity Losses GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity Losses GO:0050591 quinine 3-monooxygenase activity Losses GO:0001221 transcription cofactor binding Losses GO:0001224 RNA polymerase II transcription cofactor binding Losses GO:0005500 juvenile hormone binding Losses GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity Losses GO:0030553 cGMP binding Losses GO:0030523 dihydrolipoamide S-acyltransferase activity Losses GO:0004884 ecdysteroid hormone receptor activity Losses GO:0004821 histidine-tRNA ligase activity Losses GO:0000146 microfilament motor activity Losses GO:0004686 elongation factor-2 kinase activity Losses GO:0048185 activin binding Losses GO:0033777 lithocholate 6beta-hydroxylase activity Losses GO:0016420 malonyltransferase activity Losses GO:0016419 S-malonyltransferase activity Losses GO:0017002 activin-activated receptor activity Losses GO:0050308 sugar-phosphatase activity Losses GO:0018685 alkane 1-monooxygenase activity Losses GO:0019239 deaminase activity Losses GO:0003690 double-stranded DNA binding Losses GO:0016417 S-acyltransferase activity Losses GO:0004736 pyruvate carboxylase activity Extinctions GO:0004075 biotin carboxylase activity Extinctions GO:0016840 carbon-nitrogen lyase activity Extinctions GO:0042302 structural constituent of cuticle Extinctions GO:0016885 ligase activity, forming carbon-carbon bonds Extinctions GO:0016815 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Extinctions GO:0008255 ecdysis-triggering hormone activity Extinctions GO:0047880 erythrulose reductase activity Extinctions GO:0000257 nitrilase activity Extinctions GO:0070037 rRNA (pseudouridine) methyltransferase activity Extinctions GO:0004055 argininosuccinate synthase activity Extinctions GO:0004056 argininosuccinate lyase activity Extinctions GO:0016879 ligase activity, forming carbon-nitrogen bonds Extinctions GO:0003743 translation initiation factor activity Extinctions GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding Extinctions GO:0004879 nuclear receptor activity Extinctions GO:0003707 steroid hormone receptor activity Extinctions GO:0016843 amine-lyase activity Extinctions GO:0016844 strictosidine synthase activity Extinctions GO:0004328 formamidase activity Extinctions GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity Extinctions GO:0030523 dihydrolipoamide S-acyltransferase activity Extinctions GO:0004821 histidine-tRNA ligase activity Extinctions GO:0000146 microfilament motor activity Extinctions GO:0004686 elongation factor-2 kinase activity Extinctions GO:0003676 nucleic acid binding Extinctions GO:0016286 small conductance calcium-activated potassium channel activity Extinctions GO:0016842 amidine-lyase activity Extinctions GO:0016418 S-acetyltransferase activity Extinctions GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Extinctions GO:0016874 ligase activity Extinctions GO:0002039 p53 binding Extinctions GO:0008135 translation factor activity, RNA binding Extinctions