GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Gains
GO:0015294	solute:cation symporter activity	Gains
GO:0015293	symporter activity	Gains
GO:0015291	secondary active transmembrane transporter activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0015295	solute:proton symporter activity	Gains
GO:0005351	sugar:proton symporter activity	Gains
GO:0005402	cation:sugar symporter activity	Gains
GO:0000156	phosphorelay response regulator activity	Gains
GO:0015144	carbohydrate transmembrane transporter activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0016149	translation release factor activity, codon specific	Gains
GO:0051119	sugar transmembrane transporter activity	Gains
GO:0005343	organic acid:sodium symporter activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0022804	active transmembrane transporter activity	Gains
GO:0048037	cofactor binding	Gains
GO:0017153	sodium:dicarboxylate symporter activity	Gains
GO:0030170	pyridoxal phosphate binding	Gains
GO:0070279	vitamin B6 binding	Gains
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
GO:0016491	oxidoreductase activity	Gains
GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
GO:0019842	vitamin binding	Gains
GO:0015370	solute:sodium symporter activity	Gains
GO:0019238	cyclohydrolase activity	Gains
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Gains
GO:0043115	precorrin-2 dehydrogenase activity	Gains
GO:0016151	nickel cation binding	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0046943	carboxylic acid transmembrane transporter activity	Gains
GO:0005342	organic acid transmembrane transporter activity	Gains
GO:0008514	organic anion transmembrane transporter activity	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0015035	protein disulfide oxidoreductase activity	Gains
GO:0016829	lyase activity	Gains
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0008483	transaminase activity	Gains
GO:0016769	transferase activity, transferring nitrogenous groups	Gains
GO:0003824	catalytic activity	Gains
GO:0015081	sodium ion transmembrane transporter activity	Gains
GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
GO:0016500	protein-hormone receptor activity	Gains
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
GO:0008324	cation transmembrane transporter activity	Gains
GO:0015296	anion:cation symporter activity	Gains
GO:0004736	pyruvate carboxylase activity	Gains
GO:0008658	penicillin binding	Gains
GO:0004070	aspartate carbamoyltransferase activity	Gains
GO:0016774	phosphotransferase activity, carboxyl group as acceptor	Gains
GO:0008169	C-methyltransferase activity	Gains
GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
GO:0008113	peptide-methionine (S)-S-oxide reductase activity	Gains
GO:0043682	copper-transporting ATPase activity	Gains
GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
GO:0015036	disulfide oxidoreductase activity	Gains
GO:0016763	transferase activity, transferring pentosyl groups	Gains
GO:0008509	anion transmembrane transporter activity	Gains
GO:0016462	pyrophosphatase activity	Gains
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0008079	translation termination factor activity	Gains
GO:0003747	translation release factor activity	Gains
GO:0016615	malate dehydrogenase activity	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
GO:0016209	antioxidant activity	Gains
GO:0009055	electron transfer activity	Gains
GO:0042302	structural constituent of cuticle	Losses
GO:0005179	hormone activity	Losses
GO:0004016	adenylate cyclase activity	Losses
GO:0019136	deoxynucleoside kinase activity	Losses
GO:0004797	thymidine kinase activity	Losses
GO:0015183	L-aspartate transmembrane transporter activity	Losses
GO:0015501	glutamate:sodium symporter activity	Losses
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Losses
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Losses
GO:0005184	neuropeptide hormone activity	Losses
GO:0003729	mRNA binding	Losses
GO:0048037	cofactor binding	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0035250	UDP-galactosyltransferase activity	Losses
GO:0004364	glutathione transferase activity	Losses
GO:0048018	receptor ligand activity	Losses
GO:0005201	extracellular matrix structural constituent	Losses
GO:0004629	phospholipase C activity	Losses
GO:0004435	phosphatidylinositol phospholipase C activity	Losses
GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Losses
GO:0015278	calcium-release channel activity	Losses
GO:0005416	cation:amino acid symporter activity	Losses
GO:0099604	ligand-gated calcium channel activity	Losses
GO:0005283	sodium:amino acid symporter activity	Losses
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0030545	receptor regulator activity	Losses
GO:0008378	galactosyltransferase activity	Losses
GO:0016740	transferase activity	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0009881	photoreceptor activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0008889	glycerophosphodiester phosphodiesterase activity	Losses
GO:0000828	inositol hexakisphosphate kinase activity	Losses
GO:0000832	inositol hexakisphosphate 5-kinase activity	Losses
GO:0052723	inositol hexakisphosphate 1-kinase activity	Losses
GO:0052724	inositol hexakisphosphate 3-kinase activity	Losses
GO:0015556	C4-dicarboxylate transmembrane transporter activity	Losses
GO:0047915	ganglioside galactosyltransferase activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0005509	calcium ion binding	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0050662	coenzyme binding	Losses
GO:0015172	acidic amino acid transmembrane transporter activity	Losses
GO:0005313	L-glutamate transmembrane transporter activity	Losses
GO:0072341	modified amino acid binding	Losses
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
GO:0017048	Rho GTPase binding	Losses
GO:0015179	L-amino acid transmembrane transporter activity	Losses
GO:0005217	intracellular ligand-gated ion channel activity	Losses
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0048018	receptor ligand activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0140104	molecular carrier activity	Extinctions
GO:0051192	prosthetic group binding	Extinctions
GO:0031177	phosphopantetheine binding	Extinctions
GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
GO:0008613	diuretic hormone activity	Extinctions
GO:0019784	NEDD8-specific protease activity	Extinctions
GO:0001888	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Extinctions
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	Extinctions
GO:0015562	efflux transmembrane transporter activity	Extinctions
GO:0000036	acyl carrier activity	Extinctions
GO:0019706	protein-cysteine S-palmitoyltransferase activity	Extinctions
GO:0019707	protein-cysteine S-acyltransferase activity	Extinctions