Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00005 PF12698 PF00005 1 0 1 0 0 0 PF00009 0 1 0 0 0 0 PF00009 PF03144 PF14492 0 0 2 0 0 0 PF00013 0 1 0 0 0 0 PF00018 PF00069 1 0 0 0 0 0 PF00018 PF02759 1 0 0 0 0 0 PF00018 PF14604 1 0 0 0 0 0 PF00019 0 1 0 0 0 0 PF00035 0 1 0 0 0 0 PF00043 0 2 0 0 0 0 PF00053 PF00008 1 0 0 0 0 0 PF00053 PF00052 PF00053 PF02210 1 0 0 0 0 0 PF00069 0 2 0 0 0 0 PF00069 PF07679 1 0 38 0 0 0 PF00069 PF10409 1 0 0 0 0 0 PF00077 PF00665 1 0 0 0 0 0 PF00084 0 1 0 0 0 0 PF00090 PF05986 1 0 0 0 0 0 PF00095 PF00084 1 0 0 0 0 0 PF00096 PF13912 PF12874 1 0 0 0 0 0 PF00097 PF00642 1 0 0 0 0 0 PF00098 PF00270 PF00271 1 0 0 0 0 0 PF00106 PF13561 1 0 0 0 0 0 PF00108 0 0 3 0 0 0 PF00108 PF02803 0 1 0 0 0 0 PF00134 0 1 0 0 0 0 PF00168 PF00616 0 0 2 0 0 0 PF00211 0 1 0 0 0 0 PF00233 0 1 0 0 0 0 PF00258 0 1 0 0 0 0 PF00261 0 1 0 0 0 0 PF00270 PF00271 0 1 0 0 0 0 PF00271 PF04408 0 1 0 0 0 0 PF00289 PF02786 PF02785 0 1 3 0 0 0 PF00318 0 1 0 0 0 0 PF00373 PF09380 PF00769 0 1 0 0 0 0 PF00385 PF00176 PF00271 1 0 2 0 0 0 PF00394 PF07731 0 0 1 0 0 0 PF00397 0 1 0 0 0 0 PF00400 PF00160 1 0 0 0 0 0 PF00412 PF00788 1 0 0 0 0 0 PF00435 PF10541 1 0 0 0 0 0 PF00530 0 0 3 0 0 0 PF00536 0 1 0 0 0 0 PF00567 0 1 0 0 0 0 PF00575 0 1 0 0 0 0 PF00578 0 0 1 0 0 0 PF00587 PF03129 1 0 2 0 0 0 PF00595 PF00621 1 0 0 0 0 0 PF00609 0 0 6 0 0 0 PF00610 0 1 6 0 0 0 PF00617 0 1 0 0 0 0 PF00618 0 1 5 0 0 0 PF00620 0 1 0 0 0 0 PF00653 0 1 0 0 0 0 PF00667 PF00175 0 1 0 0 0 0 PF00670 0 1 0 0 0 0 PF00675 0 1 3 0 0 0 PF00682 PF02436 PF00364 0 1 0 0 0 0 PF00688 0 1 0 0 0 0 PF00781 PF00609 0 1 3 0 0 0 PF00784 0 1 0 0 0 0 PF00787 0 1 0 0 0 0 PF00789 0 1 0 0 0 0 PF00822 0 0 0 0 1 0 PF00916 0 1 0 0 0 0 PF00955 0 1 0 0 0 0 PF01074 0 1 6 0 0 0 PF01074 PF09261 0 1 0 0 0 0 PF01079 0 1 0 0 0 0 PF01085 0 1 0 0 0 0 PF01094 0 1 0 0 0 0 PF01094 PF10613 1 0 6 0 0 0 PF01138 PF03725 PF03726 PF01138 0 1 0 0 0 0 PF01146 0 0 0 0 1 0 PF01207 PF00035 1 0 0 0 0 0 PF01249 0 0 0 0 1 0 PF01290 0 1 0 0 0 0 PF01369 0 0 2 0 0 0 PF01382 0 0 0 0 1 0 PF01392 0 1 0 0 0 0 PF01411 0 0 3 0 0 0 PF01421 0 1 0 0 0 0 PF01479 0 0 1 0 0 0 PF01534 0 1 0 0 0 0 PF01562 0 1 0 0 0 0 PF01590 0 1 0 0 0 0 PF01602 0 0 11 0 0 0 PF01715 0 1 0 0 0 0 PF01740 0 1 0 0 0 0 PF01749 PF00514 0 0 1 0 0 0 PF01846 0 1 0 0 0 0 PF01926 0 1 0 0 0 0 PF02036 0 1 0 0 0 0 PF02141 PF03455 0 1 0 0 0 0 PF02171 0 1 0 0 0 0 PF02188 0 0 2 0 0 0 PF02190 0 1 2 0 0 0 PF02204 PF12796 PF00023 1 0 0 0 0 0 PF02212 0 0 5 0 0 0 PF02259 PF08771 PF00454 PF02260 0 0 1 0 0 0 PF02262 0 0 3 0 0 0 PF02263 0 0 1 0 0 0 PF02274 0 0 0 0 1 0 PF02285 0 0 0 0 1 0 PF02358 0 0 1 0 0 0 PF02363 0 0 0 0 1 0 PF02366 0 0 2 0 0 0 PF02494 0 1 0 0 0 0 PF02671 PF08295 0 0 1 0 0 0 PF02736 PF00063 0 0 2 0 0 0 PF02798 0 1 3 0 0 0 PF02824 0 0 5 0 0 0 PF02825 PF02862 1 0 0 0 0 0 PF02889 0 1 9 0 0 0 PF02984 0 1 0 0 0 0 PF03016 0 1 0 0 0 0 PF03028 0 1 0 0 0 0 PF03097 0 0 3 0 0 0 PF03184 PF05225 1 0 0 0 0 0 PF03200 0 0 1 0 0 0 PF03456 0 1 5 0 0 0 PF03530 0 0 2 0 0 0 PF03810 0 1 0 0 0 0 PF03876 0 1 1 0 0 0 PF03945 0 0 0 0 0 1 PF04065 0 1 0 0 0 0 PF04153 0 1 0 0 0 0 PF04840 0 1 0 0 0 0 PF04841 0 1 0 0 0 0 PF04937 0 1 0 0 0 0 PF05033 PF00856 0 1 0 0 0 0 PF05188 0 1 1 0 0 0 PF05192 PF00488 0 1 0 0 0 0 PF05193 0 1 0 0 0 0 PF05221 0 1 0 0 0 0 PF05225 PF03184 1 0 0 0 0 0 PF05225 PF03221 1 0 0 0 0 0 PF05225 PF03221 PF03184 1 0 0 0 0 0 PF05380 PF00665 1 0 0 0 0 0 PF05485 PF13359 1 0 0 0 0 0 PF05593 PF15636 0 1 0 0 0 0 PF05699 0 1 0 0 0 0 PF05729 PF12796 PF00023 1 0 0 0 0 0 PF05773 PF00270 PF00271 PF04408 PF07717 1 0 0 0 0 0 PF05874 0 0 0 0 1 0 PF05920 0 1 0 0 0 0 PF06071 0 1 0 0 0 0 PF06650 0 1 3 0 0 0 PF06733 0 0 3 0 0 0 PF06757 0 0 0 0 1 0 PF07562 PF00003 0 1 0 0 0 0 PF07565 0 1 0 0 0 0 PF07707 PF01344 1 0 0 0 0 0 PF07717 0 1 4 0 0 0 PF07748 0 1 6 0 0 0 PF07776 PF00096 PF13894 PF00096 PF12874 1 0 0 0 0 0 PF07776 PF12874 PF13894 1 0 0 0 0 0 PF07776 PF12874 PF13894 PF12874 1 0 0 0 0 0 PF07776 PF13894 PF12874 PF13894 1 0 0 0 0 0 PF07776 PF13909 1 0 0 0 0 0 PF07776 PF13912 PF12874 1 0 0 0 0 0 PF07974 0 1 0 0 0 0 PF08040 0 0 0 0 1 0 PF08393 0 1 0 0 0 0 PF08441 0 0 1 0 0 0 PF08544 0 0 2 0 0 0 PF08699 PF02170 0 1 0 0 0 0 PF08991 0 0 0 0 1 0 PF09258 0 1 0 0 0 0 PF09261 PF07748 0 1 0 0 0 0 PF09325 0 1 0 0 0 0 PF09379 0 1 10 0 0 0 PF09379 PF00373 PF09380 PF13920 1 0 0 0 0 0 PF09409 0 1 0 0 0 0 PF09811 PF13679 1 0 0 0 0 0 PF10373 0 0 1 0 0 0 PF10433 0 0 1 0 0 0 PF11601 PF02214 PF00520 0 1 0 0 0 0 PF11705 0 0 1 0 0 0 PF11879 0 1 0 0 0 0 PF11901 0 1 0 0 0 0 PF11987 0 1 0 0 0 0 PF12145 0 0 1 0 0 0 PF12171 0 1 0 0 0 0 PF12248 0 1 0 0 0 0 PF12257 0 1 0 0 0 0 PF12356 PF00179 0 1 0 0 0 0 PF12474 0 1 0 0 0 0 PF12494 0 0 0 0 1 0 PF12624 PF16908 0 1 3 0 0 0 PF12706 0 0 1 0 0 0 PF12718 0 1 0 0 0 0 PF12755 0 0 1 0 0 0 PF12774 0 1 0 0 0 0 PF12775 PF12780 0 1 0 0 0 0 PF12777 PF12781 PF03028 0 1 0 0 0 0 PF12780 PF12777 0 0 2 0 0 0 PF12780 PF12777 PF12781 0 1 0 0 0 0 PF12796 0 1 0 0 0 0 PF12872 0 1 0 0 0 0 PF12874 PF13894 PF13912 PF12874 1 0 0 0 0 0 PF12895 PF13424 1 0 0 0 0 0 PF13417 0 1 2 0 0 0 PF13513 0 1 0 0 0 0 PF13540 0 0 1 0 0 0 PF13564 0 0 0 0 1 0 PF13637 PF12796 PF00520 1 0 0 0 0 0 PF13672 0 0 0 0 1 0 PF13855 PF13306 PF01582 1 0 0 0 0 0 PF13857 PF12796 1 0 0 0 0 0 PF13894 PF00096 PF12874 1 0 0 0 0 0 PF13912 PF12874 PF13894 1 0 0 0 0 0 PF13918 0 0 1 0 0 0 PF13920 0 1 0 0 0 0 PF13923 0 1 0 0 0 0 PF14223 PF00098 1 0 0 0 0 0 PF14637 PF14638 0 0 1 0 0 0 PF14786 0 1 0 0 0 0 PF14960 0 0 0 0 1 0 PF15936 PF00412 1 0 0 0 0 0 PF16114 PF02629 PF00549 PF00285 0 0 1 0 0 0 PF16122 0 1 0 0 0 0 PF16214 0 1 3 0 0 0 PF16482 0 1 0 0 0 0 PF16493 0 1 0 0 0 0 PF16909 0 1 0 0 0 0 PF16910 PF06650 0 1 0 0 0 0