GO:0003964 RNA-directed DNA polymerase activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0034061 DNA polymerase activity Gains GO:0030695 GTPase regulator activity Gains GO:0060589 nucleoside-triphosphatase regulator activity Gains GO:0003676 nucleic acid binding Gains GO:0005096 GTPase activator activity Gains GO:0022836 gated channel activity Gains GO:0046872 metal ion binding Gains GO:0008234 cysteine-type peptidase activity Gains GO:0043169 cation binding Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0003677 DNA binding Gains GO:0008028 monocarboxylic acid transmembrane transporter activity Gains GO:0005488 binding Gains GO:0016779 nucleotidyltransferase activity Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0008233 peptidase activity Gains GO:0004518 nuclease activity Gains GO:0004222 metalloendopeptidase activity Gains GO:0003678 DNA helicase activity Gains GO:0099600 transmembrane receptor activity Gains GO:0004175 endopeptidase activity Gains GO:0003777 microtubule motor activity Gains GO:0004867 serine-type endopeptidase inhibitor activity Gains GO:0036081 extracellular ammonia-gated ion channel activity Gains GO:0004435 phosphatidylinositol phospholipase C activity Gains GO:0004629 phospholipase C activity Gains GO:0060089 molecular transducer activity Gains GO:0004715 non-membrane spanning protein tyrosine kinase activity Gains GO:0022832 voltage-gated channel activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0046914 transition metal ion binding Gains GO:0098772 molecular function regulator Gains GO:0015125 bile acid transmembrane transporter activity Gains GO:0005109 frizzled binding Gains GO:0008508 bile acid:sodium symporter activity Gains GO:0005319 lipid transporter activity Gains GO:0005262 calcium channel activity Gains GO:0097159 organic cyclic compound binding Gains GO:0030234 enzyme regulator activity Gains GO:1901363 heterocyclic compound binding Gains GO:0004871 signal transducer activity Gains GO:0004872 receptor activity Gains GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Gains GO:0005261 cation channel activity Gains GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Gains GO:0004888 transmembrane signaling receptor activity Gains GO:0004519 endonuclease activity Gains GO:0016787 hydrolase activity Gains GO:0004697 protein kinase C activity Gains GO:0038023 signaling receptor activity Gains GO:0030414 peptidase inhibitor activity Gains GO:0008270 zinc ion binding Gains GO:0019904 protein domain specific binding Gains GO:0004866 endopeptidase inhibitor activity Gains GO:0015276 ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0008092 cytoskeletal protein binding Gains GO:0004857 enzyme inhibitor activity Gains GO:0005102 receptor binding Gains GO:0008017 microtubule binding Gains GO:0003774 motor activity Gains GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Gains GO:0004672 protein kinase activity Gains GO:0001664 G-protein coupled receptor binding Gains GO:0033868 Goodpasture-antigen-binding protein kinase activity Gains GO:0004342 glucosamine-6-phosphate deaminase activity Gains GO:0005178 integrin binding Gains GO:0005248 voltage-gated sodium channel activity Gains GO:0050113 inositol oxygenase activity Gains GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential Gains GO:0004654 polyribonucleotide nucleotidyltransferase activity Gains GO:0016929 SUMO-specific protease activity Gains GO:0030594 neurotransmitter receptor activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0015296 anion:cation symporter activity Gains GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses Gains GO:0016405 CoA-ligase activity Gains GO:0061135 endopeptidase regulator activity Gains GO:0015085 calcium ion transmembrane transporter activity Gains GO:0015631 tubulin binding Gains GO:0008236 serine-type peptidase activity Gains GO:0003682 chromatin binding Gains GO:0008199 ferric iron binding Gains GO:0051082 unfolded protein binding Gains GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Gains GO:1901618 organic hydroxy compound transmembrane transporter activity Gains GO:0004835 tubulin-tyrosine ligase activity Gains GO:0003747 translation release factor activity Gains GO:0005245 voltage-gated calcium channel activity Gains GO:0008079 translation termination factor activity Gains GO:0097003 adipokinetic hormone receptor activity Losses GO:0097004 adipokinetic hormone binding Losses GO:0017046 peptide hormone binding Losses GO:0008010 structural constituent of chitin-based larval cuticle Losses GO:0016744 transferase activity, transferring aldehyde or ketonic groups Losses GO:0008238 exopeptidase activity Losses GO:0042277 peptide binding Losses GO:0042834 peptidoglycan binding Losses GO:0042302 structural constituent of cuticle Losses GO:0005214 structural constituent of chitin-based cuticle Losses GO:0033218 amide binding Losses GO:0016500 protein-hormone receptor activity Losses GO:0003950 NAD+ ADP-ribosyltransferase activity Losses GO:0004869 cysteine-type endopeptidase inhibitor activity Losses GO:0004721 phosphoprotein phosphatase activity Losses GO:0016763 transferase activity, transferring pentosyl groups Losses GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Losses GO:0042562 hormone binding Losses GO:0016746 transferase activity, transferring acyl groups Losses GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups Losses GO:0005041 low-density lipoprotein receptor activity Losses GO:0042947 glucoside transmembrane transporter activity Losses GO:0004014 adenosylmethionine decarboxylase activity Losses GO:0015151 alpha-glucoside transmembrane transporter activity Losses GO:0004034 aldose 1-epimerase activity Losses GO:0030023 extracellular matrix constituent conferring elasticity Losses GO:0032500 muramyl dipeptide binding Losses GO:0047980 hippurate hydrolase activity Losses GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Losses GO:0015220 choline transmembrane transporter activity Losses GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Losses GO:0052826 inositol hexakisphosphate 2-phosphatase activity Losses GO:0050093 methanol dehydrogenase activity Losses GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0004325 ferrochelatase activity Losses GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity Losses GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity Losses GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Losses GO:0004446 inositol-hexakisphosphate phosphatase activity Losses GO:0015574 trehalose transmembrane transporter activity Losses GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity Losses GO:0035237 corazonin receptor activity Losses GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0004146 dihydrofolate reductase activity Losses GO:0097493 structural molecule activity conferring elasticity Losses GO:0000404 heteroduplex DNA loop binding Losses GO:0000406 double-strand/single-strand DNA junction binding Losses GO:0008805 carbon-monoxide oxygenase activity Losses GO:0004793 threonine aldolase activity Losses GO:0004756 selenide, water dikinase activity Losses GO:0015098 molybdate ion transmembrane transporter activity Losses GO:0050111 mycocerosate synthase activity Losses GO:0004802 transketolase activity Losses GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity Losses GO:0016622 oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor Losses GO:0050262 ribosylnicotinamide kinase activity Losses GO:0003984 acetolactate synthase activity Losses GO:0030586 [methionine synthase] reductase activity Losses GO:0003919 FMN adenylyltransferase activity Losses GO:0001875 lipopolysaccharide receptor activity Losses GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity Losses GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Losses GO:0016019 peptidoglycan receptor activity Losses GO:0015412 ATPase-coupled molybdate transmembrane transporter activity Losses GO:0016918 retinal binding Losses GO:0030983 mismatched DNA binding Losses GO:0016829 lyase activity Losses GO:0016830 carbon-carbon lyase activity Losses GO:0004180 carboxypeptidase activity Losses GO:0004312 fatty acid synthase activity Losses GO:0016791 phosphatase activity Losses GO:0003824 catalytic activity Losses GO:0004866 endopeptidase inhibitor activity Losses GO:0004040 amidase activity Losses GO:0015154 disaccharide transmembrane transporter activity Losses GO:0015157 oligosaccharide transmembrane transporter activity Losses GO:0019788 NEDD8 transferase activity Losses GO:0008329 signaling pattern recognition receptor activity Losses GO:0038187 pattern recognition receptor activity Losses GO:0033777 lithocholate 6beta-hydroxylase activity Losses GO:0017018 myosin phosphatase activity Losses GO:0016420 malonyltransferase activity Losses GO:0016419 S-malonyltransferase activity Losses GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity Losses GO:0031386 protein tag Losses GO:0003834 beta-carotene 15,15'-monooxygenase activity Losses GO:0004142 diacylglycerol cholinephosphotransferase activity Losses GO:0005212 structural constituent of eye lens Losses GO:0016781 phosphotransferase activity, paired acceptors Losses GO:0000403 Y-form DNA binding Losses GO:0030228 lipoprotein particle receptor activity Losses GO:0031208 POZ domain binding Losses GO:0004817 cysteine-tRNA ligase activity Losses GO:0008613 diuretic hormone activity Losses GO:0032135 DNA insertion or deletion binding Losses GO:0032137 guanine/thymine mispair binding Losses GO:0005501 retinoid binding Losses GO:0032138 single base insertion or deletion binding Losses GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity Losses GO:0003913 DNA photolyase activity Losses GO:0003904 deoxyribodipyrimidine photo-lyase activity Losses GO:0008011 structural constituent of pupal chitin-based cuticle Losses GO:0050591 quinine 3-monooxygenase activity Losses GO:0070011 peptidase activity, acting on L-amino acid peptides Losses GO:0061135 endopeptidase regulator activity Losses GO:0004869 cysteine-type endopeptidase inhibitor activity Extinctions GO:0005041 low-density lipoprotein receptor activity Extinctions GO:0004034 aldose 1-epimerase activity Extinctions GO:0032500 muramyl dipeptide binding Extinctions GO:0047980 hippurate hydrolase activity Extinctions GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Extinctions GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Extinctions GO:0052826 inositol hexakisphosphate 2-phosphatase activity Extinctions GO:0050093 methanol dehydrogenase activity Extinctions GO:0004325 ferrochelatase activity Extinctions GO:0004446 inositol-hexakisphosphate phosphatase activity Extinctions GO:0035237 corazonin receptor activity Extinctions GO:0004146 dihydrofolate reductase activity Extinctions GO:0008805 carbon-monoxide oxygenase activity Extinctions GO:0004793 threonine aldolase activity Extinctions GO:0015098 molybdate ion transmembrane transporter activity Extinctions GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity Extinctions GO:0016622 oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor Extinctions GO:0050262 ribosylnicotinamide kinase activity Extinctions GO:0003984 acetolactate synthase activity Extinctions GO:0030586 [methionine synthase] reductase activity Extinctions GO:0003919 FMN adenylyltransferase activity Extinctions GO:0001875 lipopolysaccharide receptor activity Extinctions GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity Extinctions GO:0016019 peptidoglycan receptor activity Extinctions GO:0015412 ATPase-coupled molybdate transmembrane transporter activity Extinctions GO:0016918 retinal binding Extinctions GO:0004866 endopeptidase inhibitor activity Extinctions GO:0061135 endopeptidase regulator activity Extinctions GO:0008238 exopeptidase activity Extinctions GO:0042277 peptide binding Extinctions GO:0030414 peptidase inhibitor activity Extinctions GO:0004040 amidase activity Extinctions GO:0019788 NEDD8 transferase activity Extinctions GO:0008329 signaling pattern recognition receptor activity Extinctions GO:0038187 pattern recognition receptor activity Extinctions GO:0033777 lithocholate 6beta-hydroxylase activity Extinctions GO:0097003 adipokinetic hormone receptor activity Extinctions GO:0097004 adipokinetic hormone binding Extinctions GO:0003834 beta-carotene 15,15'-monooxygenase activity Extinctions GO:0004142 diacylglycerol cholinephosphotransferase activity Extinctions GO:0030228 lipoprotein particle receptor activity Extinctions GO:0031208 POZ domain binding Extinctions GO:0004817 cysteine-tRNA ligase activity Extinctions GO:0008613 diuretic hormone activity Extinctions GO:0005501 retinoid binding Extinctions GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity Extinctions GO:0003913 DNA photolyase activity Extinctions GO:0003904 deoxyribodipyrimidine photo-lyase activity Extinctions GO:0050591 quinine 3-monooxygenase activity Extinctions GO:0033218 amide binding Extinctions GO:0061134 peptidase regulator activity Extinctions GO:0017046 peptide hormone binding Extinctions GO:0004307 ethanolaminephosphotransferase activity Extinctions GO:0004463 leukotriene-A4 hydrolase activity Extinctions GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Extinctions GO:0003681 bent DNA binding Extinctions GO:0004814 arginine-tRNA ligase activity Extinctions GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Extinctions GO:0048244 phytanoyl-CoA dioxygenase activity Extinctions