GO:0046914 transition metal ion binding Gains GO:0008270 zinc ion binding Gains GO:0016615 malate dehydrogenase activity Gains GO:0046872 metal ion binding Gains GO:0043169 cation binding Gains GO:0033743 peptide-methionine (R)-S-oxide reductase activity Gains GO:0004866 endopeptidase inhibitor activity Gains GO:0061135 endopeptidase regulator activity Gains GO:0070330 aromatase activity Gains GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Gains GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Gains GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity Gains GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Gains GO:0004368 glycerol-3-phosphate dehydrogenase activity Gains GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Gains GO:0004559 alpha-mannosidase activity Gains GO:0030414 peptidase inhibitor activity Gains GO:0004857 enzyme inhibitor activity Gains GO:0005507 copper ion binding Gains GO:0003696 satellite DNA binding Gains GO:0030060 L-malate dehydrogenase activity Gains GO:0015923 mannosidase activity Gains GO:0016229 steroid dehydrogenase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0061134 peptidase regulator activity Gains GO:0019201 nucleotide kinase activity Gains GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Gains GO:0004017 adenylate kinase activity Gains GO:0004303 estradiol 17-beta-dehydrogenase activity Gains GO:0004497 monooxygenase activity Gains GO:0019205 nucleobase-containing compound kinase activity Gains GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Gains GO:0004869 cysteine-type endopeptidase inhibitor activity Gains GO:0019206 nucleoside kinase activity Gains GO:0046933 proton-transporting ATP synthase activity, rotational mechanism Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Gains GO:0043167 ion binding Gains GO:0004415 hyalurononglucosaminidase activity Gains GO:0035198 miRNA binding Gains GO:0004164 diphthine synthase activity Gains GO:0005275 amine transmembrane transporter activity Gains GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Gains GO:0004131 cytosine deaminase activity Gains GO:0004105 choline-phosphate cytidylyltransferase activity Gains GO:0004108 citrate (Si)-synthase activity Gains GO:0008836 diaminopimelate decarboxylase activity Gains GO:0080023 3R-hydroxyacyl-CoA dehydratase activity Gains GO:0016603 glutaminyl-peptide cyclotransferase activity Gains GO:0036440 citrate synthase activity Gains GO:0004586 ornithine decarboxylase activity Gains GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity Gains GO:0004516 nicotinate phosphoribosyltransferase activity Gains GO:0016936 galactoside binding Gains GO:0032454 histone demethylase activity (H3-K9 specific) Gains GO:0008046 axon guidance receptor activity Gains GO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity Gains GO:0005094 Rho GDP-dissociation inhibitor activity Gains GO:0015250 water channel activity Gains GO:0070379 high mobility group box 1 binding Gains GO:0052869 arachidonic acid omega-hydroxylase activity Gains GO:0052870 tocopherol omega-hydroxylase activity Gains GO:0052871 alpha-tocopherol omega-hydroxylase activity Gains GO:0004062 aryl sulfotransferase activity Gains GO:0004027 alcohol sulfotransferase activity Gains GO:0050051 leukotriene-B4 20-monooxygenase activity Gains GO:0005372 water transmembrane transporter activity Gains GO:0004369 glycerol-3-phosphate oxidase activity Gains GO:0004352 glutamate dehydrogenase (NAD+) activity Gains GO:0004353 glutamate dehydrogenase [NAD(P)+] activity Gains GO:0004372 glycine hydroxymethyltransferase activity Gains GO:0005430 synaptic vesicle amine transmembrane transporter activity Gains GO:0036082 extracellular phenylacetaldehyde-gated ion channel activity Gains GO:0004304 estrone sulfotransferase activity Gains GO:0016776 phosphotransferase activity, phosphate group as acceptor Gains GO:0018024 histone-lysine N-methyltransferase activity Gains GO:0016278 lysine N-methyltransferase activity Gains GO:0016279 protein-lysine N-methyltransferase activity Gains GO:0022824 transmitter-gated ion channel activity Losses GO:0022835 transmitter-gated channel activity Losses GO:0004970 ionotropic glutamate receptor activity Losses GO:0005234 extracellularly glutamate-gated ion channel activity Losses GO:0004180 carboxypeptidase activity Losses GO:0005231 excitatory extracellular ligand-gated ion channel activity Losses GO:0008238 exopeptidase activity Losses GO:0008066 glutamate receptor activity Losses GO:0033777 lithocholate 6beta-hydroxylase activity Losses GO:0048531 beta-1,3-galactosyltransferase activity Losses GO:0003680 AT DNA binding Losses GO:0050591 quinine 3-monooxygenase activity Losses GO:2001070 starch binding Losses GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity Losses GO:0030594 neurotransmitter receptor activity Losses GO:0004602 glutathione peroxidase activity Losses GO:0005506 iron ion binding Losses GO:0008241 peptidyl-dipeptidase activity Losses GO:0045735 nutrient reservoir activity Losses GO:0004771 sterol esterase activity Losses GO:0046914 transition metal ion binding Losses GO:0008061 chitin binding Losses GO:0005230 extracellular ligand-gated ion channel activity Losses GO:0004806 triglyceride lipase activity Losses GO:0070011 peptidase activity, acting on L-amino acid peptides Losses GO:0008233 peptidase activity Losses GO:0001871 pattern binding Losses GO:0030247 polysaccharide binding Losses GO:0016853 isomerase activity Losses GO:0008889 glycerophosphodiester phosphodiesterase activity Losses GO:0004971 AMPA glutamate receptor activity Losses GO:0003964 RNA-directed DNA polymerase activity Losses GO:0008237 metallopeptidase activity Losses GO:0009982 pseudouridine synthase activity Losses GO:0016803 ether hydrolase activity Losses GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Losses GO:0004523 RNA-DNA hybrid ribonuclease activity Losses GO:0022834 ligand-gated channel activity Losses GO:0015276 ligand-gated ion channel activity Losses GO:0052689 carboxylic ester hydrolase activity Losses GO:0005216 ion channel activity Losses GO:0008195 phosphatidate phosphatase activity Losses GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Losses GO:0022838 substrate-specific channel activity Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0070001 aspartic-type peptidase activity Losses GO:0008010 structural constituent of chitin-based larval cuticle Losses GO:0022803 passive transmembrane transporter activity Losses GO:0015267 channel activity Losses GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Losses GO:0038023 signaling receptor activity Losses GO:0008270 zinc ion binding Losses GO:0008378 galactosyltransferase activity Losses GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Losses GO:0042947 glucoside transmembrane transporter activity Losses GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity Losses GO:0050357 tropinesterase activity Losses GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds Losses GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Losses GO:0008774 acetaldehyde dehydrogenase (acetylating) activity Losses GO:0005225 volume-sensitive anion channel activity Losses GO:0017159 pantetheine hydrolase activity Losses GO:0015026 coreceptor activity Losses GO:0070576 vitamin D 24-hydroxylase activity Losses GO:0070513 death domain binding Losses GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Losses GO:0004796 thromboxane-A synthase activity Losses GO:0004782 sulfinoalanine decarboxylase activity Losses GO:0004747 ribokinase activity Losses GO:0004865 protein serine/threonine phosphatase inhibitor activity Losses GO:0004850 uridine phosphorylase activity Losses GO:0001758 retinal dehydrogenase activity Losses GO:0004807 triose-phosphate isomerase activity Losses GO:0016034 maleylacetoacetate isomerase activity Losses GO:0070976 TIR domain binding Losses GO:0003911 DNA ligase (NAD+) activity Losses GO:0008093 cytoskeletal adaptor activity Losses GO:0050840 extracellular matrix binding Losses GO:0015151 alpha-glucoside transmembrane transporter activity Losses GO:0008967 phosphoglycolate phosphatase activity Losses GO:0015245 fatty acid transporter activity Losses GO:0047747 cholate-CoA ligase activity Losses GO:0018833 DDT-dehydrochlorinase activity Losses GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity Losses GO:0004068 aspartate 1-decarboxylase activity Losses GO:0030544 Hsp70 protein binding Losses GO:0008495 protoheme IX farnesyltransferase activity Losses GO:0015574 trehalose transmembrane transporter activity Losses GO:0072320 volume-sensitive chloride channel activity Losses GO:0005324 long-chain fatty acid transporter activity Losses GO:0004351 glutamate decarboxylase activity Losses GO:0005436 sodium:phosphate symporter activity Losses GO:0004334 fumarylacetoacetase activity Losses GO:0004301 epoxide hydrolase activity Losses GO:0022857 transmembrane transporter activity Losses GO:0008061 chitin binding Extinctions GO:0008241 peptidyl-dipeptidase activity Extinctions GO:0004180 carboxypeptidase activity Extinctions GO:0009982 pseudouridine synthase activity Extinctions GO:0008238 exopeptidase activity Extinctions GO:0022824 transmitter-gated ion channel activity Extinctions GO:0022835 transmitter-gated channel activity Extinctions GO:0004970 ionotropic glutamate receptor activity Extinctions GO:0005234 extracellularly glutamate-gated ion channel activity Extinctions GO:0005231 excitatory extracellular ligand-gated ion channel activity Extinctions GO:0008066 glutamate receptor activity Extinctions GO:0016866 intramolecular transferase activity Extinctions GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds Extinctions GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Extinctions GO:0070513 death domain binding Extinctions GO:0004865 protein serine/threonine phosphatase inhibitor activity Extinctions GO:0004807 triose-phosphate isomerase activity Extinctions GO:0003911 DNA ligase (NAD+) activity Extinctions GO:0008093 cytoskeletal adaptor activity Extinctions GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity Extinctions GO:0030544 Hsp70 protein binding Extinctions GO:0008495 protoheme IX farnesyltransferase activity Extinctions GO:0004334 fumarylacetoacetase activity Extinctions GO:0030594 neurotransmitter receptor activity Extinctions GO:0001871 pattern binding Extinctions GO:0030247 polysaccharide binding Extinctions GO:0046914 transition metal ion binding Extinctions