EOG8TQPVB GO:0008234 1/2 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG822CZN GO:0004725 2/100 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG822CZN GO:0045035 1/100 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG822CZN GO:0045747 1/100 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG822CZN GO:0005938 1/100 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG822CZN GO:0003779 1/100 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8DV82M GO:0006281 5/13 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8DV82M GO:0003684 5/13 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8DV82M GO:0003887 5/13 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8DV82J GO:0008270 9/27 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DV82K GO:0033862 1/12 UMP kinase activity molecular_function "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] EOG8DV82K GO:0005737 1/12 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DV82K GO:0006221 1/12 pyrimidine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8TXF8V GO:0000166 1/3 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8GB9NN GO:0008270 31/132 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GB9NN GO:0006352 31/132 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG8GB9NN GO:0045893 23/132 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9NN GO:0005634 23/132 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9NN GO:0006355 8/132 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9NN GO:0003743 2/132 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8GB9NN GO:0005667 1/132 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8GB9NN GO:0048812 1/132 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8GB9NN GO:0008134 1/132 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8GB9NN GO:0006359 1/132 regulation of transcription from RNA polymerase III promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators] EOG8GB9NN GO:0006383 1/132 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8SXQSC GO:0016192 2/112 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8SXQSC GO:0006886 2/112 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8SXQSC GO:0030117 1/112 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG8SXQSC GO:0003677 1/112 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SXQSC GO:0031513 1/112 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8SXQSC GO:0042384 1/112 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8SXQSC GO:0030990 1/112 intraciliary transport particle cellular_component "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] EOG8SXQSC GO:0007018 1/112 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8SXQSC GO:0005871 1/112 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8SXQSC GO:0035058 1/112 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG8SXQSC GO:0004674 1/112 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8SXQSC GO:0005524 1/112 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SXQSC GO:0005929 1/112 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8SXQSC GO:0005198 1/112 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8SXQSC GO:0007275 1/112 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8W9MK5 GO:0045454 56/189 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8W9MK5 GO:0009055 52/189 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8W9MK5 GO:0015035 52/189 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8SXQSM GO:0005319 38/153 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG8SXQSM GO:0006801 5/153 superoxide metabolic process biological_process "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] EOG8SXQSM GO:0046872 5/153 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SXQSM GO:0055114 5/153 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8V45Q1 GO:0031409 22/139 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8V45Q1 GO:0005576 19/139 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V45Q1 GO:0036094 7/139 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG8V45Q1 GO:0005215 5/139 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8V45Q1 GO:0008289 2/139 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8WQ3HM GO:0006979 15/20 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8WQ3HM GO:0020037 15/20 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8WQ3HM GO:0004601 15/20 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8WQ3HM GO:0004666 2/20 prostaglandin-endoperoxide synthase activity molecular_function "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] EOG854CFB GO:0003676 9/34 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG854CFB GO:0003677 1/34 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG854CFB GO:0005576 1/34 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8J6V63 GO:0008234 42/98 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8J6V63 GO:0000338 1/98 protein deneddylation biological_process "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] EOG8J6V63 GO:0019784 1/98 NEDD8-specific protease activity molecular_function "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] EOG8J6V63 GO:0043065 1/98 positive regulation of apoptotic process biological_process "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8SXQSQ GO:0008270 6/40 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SXQSQ GO:0005634 6/40 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SXQSQ GO:0003676 1/40 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SXQSP GO:0007224 24/89 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG8SXQSP GO:0016021 24/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SXQSP GO:0004930 24/89 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8SXQSP GO:0007275 23/89 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8SXQSP GO:0048846 1/89 axon extension involved in axon guidance biological_process "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] EOG8SXQSP GO:0090004 1/89 positive regulation of establishment of protein localization to plasma membrane biological_process "Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb] EOG8SXQSP GO:0045746 1/89 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8SXQSP GO:0001570 1/89 vasculogenesis biological_process "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] EOG8SXQSP GO:0001746 1/89 Bolwig's organ morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] EOG8SXQSP GO:0021938 1/89 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation biological_process "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] EOG8SXQSP GO:0007346 1/89 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8SXQSP GO:0045880 1/89 positive regulation of smoothened signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8SXQSP GO:0030707 1/89 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8SXQSP GO:0003007 1/89 heart morphogenesis biological_process "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] EOG8SXQSP GO:0035019 1/89 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG8SXQSP GO:2000134 1/89 negative regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8SXQSP GO:0048663 1/89 neuron fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] EOG8SXQSP GO:0042981 1/89 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8SXQSP GO:0007193 1/89 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8SXQSP GO:0017147 1/89 Wnt-protein binding molecular_function "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] EOG8SXQSP GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SXQSP GO:0048099 1/89 anterior/posterior lineage restriction, imaginal disc biological_process "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402] EOG8SXQSP GO:0060070 1/89 canonical Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] EOG8SXQSP GO:0005887 1/89 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SXQSP GO:0048100 1/89 wing disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] EOG8SXQSP GO:0043025 1/89 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8SXQSP GO:0005886 1/89 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8SXQSP GO:0021696 1/89 cerebellar cortex morphogenesis biological_process "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] EOG8SXQSP GO:0010002 1/89 cardioblast differentiation biological_process "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8SXQSP GO:0005768 1/89 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG8SXQSP GO:0005737 1/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SXQSP GO:0008406 1/89 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8SXQSP GO:0002052 1/89 positive regulation of neuroblast proliferation biological_process "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] EOG8SXQSP GO:0008158 1/89 hedgehog receptor activity molecular_function "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137] EOG8SXQSP GO:0007455 1/89 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8SXQSP GO:0042813 1/89 Wnt-activated receptor activity molecular_function "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators] EOG8SXQSP GO:0048592 1/89 eye morphogenesis biological_process "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] EOG8SXQSP GO:0004888 1/89 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8SXQSP GO:0016055 1/89 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8SXQSP GO:0031102 1/89 neuron projection regeneration biological_process "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] EOG8SXQSP GO:0007350 1/89 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8SXQSP GO:0030165 1/89 PDZ domain binding molecular_function "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] EOG8SXQSP GO:0007165 1/89 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8SXQSP GO:0007368 1/89 determination of left/right symmetry biological_process "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] EOG8SXQSP GO:0060830 1/89 ciliary receptor clustering involved in smoothened signaling pathway biological_process "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] EOG8SXQSP GO:0005929 1/89 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8SXQSP GO:0043066 1/89 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8NP9J8 GO:0046872 23/203 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NP9J8 GO:0008270 11/203 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NP9J8 GO:0003676 6/203 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NP9J8 GO:0015074 1/203 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8NP9J8 GO:0005634 1/203 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NP9J8 GO:0003723 1/203 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NP9J8 GO:0003964 1/203 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VT8DX GO:0006811 1/19 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8VT8DX GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NP9J5 GO:0000166 61/177 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NP9J5 GO:0003723 58/177 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NP9J5 GO:0003729 3/177 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8NP9J5 GO:0005634 2/177 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NP9J5 GO:0016592 2/177 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8NP9J5 GO:0001104 2/177 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8NP9J5 GO:0008266 2/177 poly(U) RNA binding molecular_function "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] EOG8NP9J5 GO:0031441 1/177 negative regulation of mRNA 3'-end processing biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] EOG8NP9J5 GO:0007319 1/177 negative regulation of oskar mRNA translation biological_process "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] EOG8NP9J5 GO:0051252 1/177 regulation of RNA metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] EOG8NP9J5 GO:0048477 1/177 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8NP9J5 GO:0060856 1/177 establishment of blood-brain barrier biological_process "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG8NP9J5 GO:0007293 1/177 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8NP9J5 GO:0007399 1/177 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8NP9J5 GO:0008049 1/177 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8NP9J5 GO:0036093 1/177 germ cell proliferation biological_process "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] EOG8NP9J5 GO:0015030 1/177 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG8NP9J5 GO:0009790 1/177 embryo development biological_process "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG8NP9J5 GO:0016491 1/177 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8NP9J5 GO:0003676 1/177 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NP9J5 GO:0000900 1/177 translation repressor activity, nucleic acid binding molecular_function "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw] EOG8NP9J5 GO:0007417 1/177 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8NP9J5 GO:0005737 1/177 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NP9J5 GO:0003730 1/177 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8NP9J5 GO:0007281 1/177 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8WQ3HZ GO:0016021 2/55 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WQ3HZ GO:0008137 1/55 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8WQ3HZ GO:0045263 1/55 proton-transporting ATP synthase complex, coupling factor F(o) cellular_component "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] EOG8WQ3HZ GO:0070469 1/55 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8WQ3HZ GO:0055114 1/55 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8WQ3HZ GO:0015986 1/55 ATP synthesis coupled proton transport biological_process "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] EOG8WQ3HZ GO:0016020 1/55 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8WQ3HZ GO:0005743 1/55 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8WQ3HZ GO:0022904 1/55 respiratory electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] EOG8WQ3HZ GO:0015078 1/55 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8WQ3HZ GO:0050136 1/55 NADH dehydrogenase (quinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN] EOG8VQD62 GO:0003677 1/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V45QS GO:0007219 2/34 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8V45QS GO:0016021 2/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V45QS GO:0007275 2/34 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG854CF8 GO:0000287 1/6 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG854CF8 GO:0009165 1/6 nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG854CF8 GO:0009156 1/6 ribonucleoside monophosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG854CF8 GO:0004749 1/6 ribose phosphate diphosphokinase activity molecular_function "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612] EOG8616K5 GO:0046873 27/88 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8616K5 GO:0016020 26/88 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8616K5 GO:0016021 1/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616K5 GO:0006829 1/88 zinc II ion transport biological_process "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K5 GO:0005622 1/88 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8616K5 GO:0000139 1/88 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8616K5 GO:0016323 1/88 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8VT8D2 GO:0004514 4/11 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736] EOG8VT8D2 GO:0009435 4/11 NAD biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] EOG8W9MKD GO:0004719 26/111 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] EOG8W9MKD GO:0005737 1/111 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W9MKD GO:0006479 1/111 protein methylation biological_process "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] EOG8W9MKD GO:0042742 1/111 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8WHC3H GO:0004190 2/39 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8WQ3H8 GO:0030170 3/22 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8WQ3H8 GO:0008483 2/22 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8WQ3H8 GO:0005524 1/22 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WQ3H8 GO:0005975 1/22 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WQ3H8 GO:0009058 1/22 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8WQ3H8 GO:0004015 1/22 adenosylmethionine-8-amino-7-oxononanoate transaminase activity molecular_function "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864] EOG8WQ3H8 GO:0009102 1/22 biotin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] EOG8WQ3H8 GO:0008974 1/22 phosphoribulokinase activity molecular_function "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19368] EOG8NP9JT GO:0048813 2/154 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8NP9JT GO:0071013 1/154 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8NP9JT GO:0000398 1/154 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8NP9JT GO:0048666 1/154 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8NP9JT GO:0007517 1/154 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8NP9JT GO:0071011 1/154 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8SXQS9 GO:0004559 100/219 alpha-mannosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] EOG8SXQS9 GO:0030246 96/219 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8SXQS9 GO:0006013 96/219 mannose metabolic process biological_process "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732] EOG8SXQS9 GO:0008270 92/219 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SXQS9 GO:0005975 8/219 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8SXQS9 GO:0015923 4/219 mannosidase activity molecular_function "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] EOG8SXQS9 GO:0003723 1/219 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8SXQS9 GO:0001522 1/219 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG8SXQS9 GO:0009982 1/219 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG8SXQS9 GO:0005576 1/219 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8DV825 GO:0003856 1/8 3-dehydroquinate synthase activity molecular_function "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971] EOG8DV822 GO:0016021 12/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5VR GO:0030031 1/4 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8NS5VR GO:0003777 1/4 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8NS5VR GO:0007018 1/4 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8NS5VR GO:0001539 1/4 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG8B5RKZ GO:0005525 1/13 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG81VNM5 GO:0003676 2/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KM1GR GO:0005506 1/100 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8KM1GR GO:0022008 1/100 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KM1GR GO:0016705 1/100 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8KM1GR GO:0020037 1/100 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8XKXMX GO:0046872 22/110 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XKXMX GO:0016491 17/110 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8XKXMX GO:0005739 4/110 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8XKXMX GO:0047988 4/110 hydroxyacid-oxoacid transhydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] EOG8XKXMX GO:0015993 4/110 molecular hydrogen transport biological_process "The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG8XKXMX GO:0050093 1/110 methanol dehydrogenase activity molecular_function "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404] EOG8FJBQQ GO:0035556 24/94 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8FJBQQ GO:0008293 1/94 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8FJBQQ GO:0007173 1/94 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8FJBQQ GO:0038202 1/94 TORC1 signaling biological_process "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] EOG8FJBQQ GO:0007426 1/94 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FJBQQ GO:0035011 1/94 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8T1M34 GO:0004843 29/94 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG8T1M34 GO:0006511 29/94 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8T1M34 GO:0005622 28/94 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8T1M34 GO:0016579 1/94 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG8T1M34 GO:0004221 1/94 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG8T1M34 GO:0005875 1/94 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8T1M37 GO:0005829 11/94 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8T1M37 GO:0005634 11/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8T1M37 GO:0005875 11/94 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8T1M37 GO:0005200 11/94 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8T1M37 GO:0008017 11/94 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8T1M37 GO:0005819 11/94 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8T1M37 GO:0005874 11/94 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8T1M37 GO:0031116 11/94 positive regulation of microtubule polymerization biological_process "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] EOG8T1M31 GO:0015627 2/9 type II protein secretion system complex cellular_component "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] EOG8T1M31 GO:0008565 2/9 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8T1M31 GO:0005524 2/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T1M31 GO:0015628 2/9 protein secretion by the type II secretion system biological_process "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] EOG8T1M31 GO:0017111 1/9 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG83R61V GO:0020037 24/59 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83R61V GO:0005506 24/59 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83R61V GO:0016705 23/59 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83R61V GO:0004497 22/59 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83R61V GO:0070330 1/59 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8CC6J4 GO:0016538 44/138 cyclin-dependent protein serine/threonine kinase regulator activity molecular_function "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] EOG8CC6J4 GO:0007049 42/138 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8CC6J4 GO:0051301 42/138 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8CC6J4 GO:0016301 9/138 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8CC6J4 GO:0005515 2/138 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CC6J4 GO:0016740 2/138 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8CC6J4 GO:0007488 1/138 histoblast morphogenesis biological_process "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] EOG8CC6J4 GO:0007113 1/138 endomitotic cell cycle biological_process "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] EOG8CC6J4 GO:0008054 1/138 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8CC6J4 GO:0007057 1/138 spindle assembly involved in female meiosis I biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] EOG8CC6J4 GO:0006468 1/138 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8CC6J4 GO:0035186 1/138 syncytial blastoderm mitotic cell cycle biological_process "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] EOG8CC6J4 GO:0007144 1/138 female meiosis I biological_process "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] EOG8CC6J4 GO:0004693 1/138 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8CC6J4 GO:0000278 1/138 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8CC6J4 GO:0051225 1/138 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8CC6J4 GO:0007143 1/138 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8CC6J4 GO:0019005 1/138 SCF ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] EOG8CC6J4 GO:0007067 1/138 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8RR8XT GO:0005524 30/112 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RR8XT GO:0004478 30/112 methionine adenosyltransferase activity molecular_function "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] EOG8RR8XT GO:0006556 30/112 S-adenosylmethionine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] EOG8RR8XT GO:0006730 28/112 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8RR8XT GO:0046872 28/112 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RR8XT GO:0022416 1/112 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8RR8XT GO:0035220 1/112 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG87DCWX GO:0016787 125/753 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG87DCWX GO:0003990 29/753 acetylcholinesterase activity molecular_function "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] EOG87DCWX GO:0052689 10/753 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG87DCWX GO:0004104 5/753 cholinesterase activity molecular_function "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] EOG87DCWX GO:0005576 3/753 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87DCWX GO:0005524 1/753 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87DCWX GO:0006730 1/753 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG87DCWX GO:0004013 1/753 adenosylhomocysteinase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] EOG87DCWX GO:0003677 1/753 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87DCWX GO:0016021 1/753 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCWX GO:0006260 1/753 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8S7N4Q GO:0008484 81/332 sulfuric ester hydrolase activity molecular_function "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] EOG8S7N4Q GO:0003943 34/332 N-acetylgalactosamine-4-sulfatase activity molecular_function "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] EOG8S7N4Q GO:0008270 1/332 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N4Q GO:0042742 1/332 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG87DCWC GO:0005524 24/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87DCWC GO:0004674 23/98 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG87DCWC GO:0004712 10/98 protein serine/threonine/tyrosine kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] EOG87DCWC GO:0046777 8/98 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG87DCWC GO:0008355 1/98 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG87DCWC GO:0006468 1/98 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG87DCWC GO:2000253 1/98 positive regulation of feeding behavior biological_process "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] EOG87DCWC GO:0007632 1/98 visual behavior biological_process "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] EOG87DCWC GO:0005634 1/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87DCWC GO:0007399 1/98 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG87DCWC GO:0030154 1/98 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG87DCWC GO:0004672 1/98 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG87DCWC GO:0045927 1/98 positive regulation of growth biological_process "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG87DCWC GO:0035332 1/98 positive regulation of hippo signaling biological_process "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf] EOG87DCWC GO:0007623 1/98 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG87DCWC GO:0007611 1/98 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8M3CPC GO:0008270 5/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M3CPC GO:0006511 4/37 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8M3CPC GO:0008234 2/37 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG87DCWN GO:0016772 137/261 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG812PM2 GO:0005634 17/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG812PM2 GO:0005737 17/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG812PM2 GO:0070328 1/95 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG812PM2 GO:0009744 1/95 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG812PM2 GO:0006897 1/95 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG812PM2 GO:0016028 1/95 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG812PM2 GO:0016059 1/95 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG812PM2 GO:0042593 1/95 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG87DCW5 GO:0016021 28/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCW5 GO:0022891 26/107 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG87DCW5 GO:0008643 4/107 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG87DCW5 GO:0032440 2/107 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG87DCW5 GO:0022857 2/107 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8ZW7X5 GO:0003676 1/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZW7X5 GO:0008270 1/7 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG812PMC GO:0005267 5/40 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG812PMC GO:0016021 5/40 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG844P37 GO:0004064 1/37 arylesterase activity molecular_function "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] EOG8WSZS7 GO:0005509 28/94 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8WSZS7 GO:0035191 1/94 nuclear axial expansion biological_process "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] EOG8WSZS7 GO:0030496 1/94 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8WSZS7 GO:0005886 1/94 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WSZS7 GO:0005938 1/94 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8WSZS7 GO:0032154 1/94 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8WSZS7 GO:0035317 1/94 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG8WSZS7 GO:0001736 1/94 establishment of planar polarity biological_process "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] EOG8WSZS7 GO:0016460 1/94 myosin II complex cellular_component "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8WSZS7 GO:0051233 1/94 spindle midzone cellular_component "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] EOG8WSZS7 GO:0090254 1/94 cell elongation involved in imaginal disc-derived wing morphogenesis biological_process "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8WSZS7 GO:0007349 1/94 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8WSZS7 GO:0005912 1/94 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8WSZS7 GO:0000281 1/94 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8WSZS7 GO:0060288 1/94 formation of a compartment boundary biological_process "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] EOG8WSZS7 GO:0019749 1/94 cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] EOG8WSZS7 GO:0022008 1/94 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WSZS7 GO:0030707 1/94 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8WSZS7 GO:0016324 1/94 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8WSZS7 GO:0032036 1/94 myosin heavy chain binding molecular_function "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah] EOG8WSZS7 GO:0035159 1/94 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG8WSZS7 GO:0035277 1/94 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8WSZS7 GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZS7 GO:0032956 1/94 regulation of actin cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] EOG8WSZS7 GO:0030048 1/94 actin filament-based movement biological_process "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] EOG8WSZS7 GO:0007298 1/94 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8WSZS7 GO:0007300 1/94 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8WSZS7 GO:0042060 1/94 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8WSZS7 GO:0035183 1/94 female germline ring canal inner rim cellular_component "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] EOG8V9X4G GO:0030239 1/60 myofibril assembly biological_process "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] EOG8V9X4G GO:0004222 1/60 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8V9X4G GO:0016021 1/60 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V9X4G GO:0019867 1/60 outer membrane cellular_component "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] EOG818F38 GO:0004623 1/89 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG8V45Q2 GO:0015171 1/8 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8V45Q2 GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KH57R GO:0005509 8/78 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8KH57R GO:0004714 1/78 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8KH57R GO:0016787 1/78 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG86Q96V GO:0016772 12/72 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Q2GX5 GO:0016020 2/9 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Q2GX5 GO:0005524 1/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Q2GX5 GO:0005215 1/9 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8Q2GX5 GO:0015439 1/9 heme-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] EOG84J4Z8 GO:0016746 22/107 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG84J4Z8 GO:0005509 18/107 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG84J4Z8 GO:0005789 1/107 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG84J4Z8 GO:0000139 1/107 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG84J4Z8 GO:0047184 1/107 1-acylglycerophosphocholine O-acyltransferase activity molecular_function "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] EOG84J4Z8 GO:0005794 1/107 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG84J4Z8 GO:0005783 1/107 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG84J4Z8 GO:0008654 1/107 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG84J4Z8 GO:0016021 1/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80GG6Z GO:0016021 2/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80GG6Z GO:0035307 1/91 positive regulation of protein dephosphorylation biological_process "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] EOG80GG6Z GO:0071595 1/91 Nem1-Spo7 phosphatase complex cellular_component "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591] EOG80GG6Z GO:0006629 1/91 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG80GG6Z GO:0010867 1/91 positive regulation of triglyceride biosynthetic process biological_process "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] EOG80GG6Z GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80GG6Z GO:0031965 1/91 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG8ZGRTM GO:0050839 1/154 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8ZGRTM GO:0031362 1/154 anchored component of external side of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8KM1GX GO:0005524 26/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1GX GO:0006298 26/99 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8KM1GX GO:0030983 25/99 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8KM1GX GO:0008094 1/99 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8KM1GX GO:0000400 1/99 four-way junction DNA binding molecular_function "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] EOG8KM1GX GO:0032138 1/99 single base insertion or deletion binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] EOG8KM1GX GO:0000228 1/99 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8KM1GX GO:0045910 1/99 negative regulation of DNA recombination biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] EOG8KM1GX GO:0000710 1/99 meiotic mismatch repair biological_process "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] EOG8KM1GX GO:0008630 1/99 intrinsic apoptotic signaling pathway in response to DNA damage biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG8KM1GX GO:0007131 1/99 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8KM1GX GO:0006200 1/99 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8KM1GX GO:0006281 1/99 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8KM1GX GO:0003684 1/99 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8KM1GX GO:0009411 1/99 response to UV biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] EOG8KM1GX GO:0043570 1/99 maintenance of DNA repeat elements biological_process "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] EOG8KM1GX GO:0032301 1/99 MutSalpha complex cellular_component "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] EOG8KM1GX GO:0032137 1/99 guanine/thymine mispair binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk] EOG8ZGRTH GO:0003935 1/14 GTP cyclohydrolase II activity molecular_function "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707] EOG8ZGRTH GO:0009231 1/14 riboflavin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] EOG8ZGRTD GO:0016021 22/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZGRTD GO:0005918 1/92 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8ZGRTD GO:0007476 1/92 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8N06WZ GO:0016998 21/74 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG88PQ10 GO:0003677 8/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88PQ10 GO:0003676 2/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88PQ11 GO:0003995 2/6 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG88PQ12 GO:0007165 2/96 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG89PDFX GO:0004721 1/64 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG89CSNV GO:0004357 26/101 glutamate-cysteine ligase activity molecular_function "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288] EOG89CSNV GO:0006750 26/101 glutathione biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] EOG89CSNV GO:0006974 1/101 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG89CSNV GO:0005921 1/101 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG89CSNV GO:0005524 1/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89CSNV GO:0006811 1/101 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89CSNV GO:0017109 1/101 glutamate-cysteine ligase complex cellular_component "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] EOG89CSNV GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89CSNV GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89CSNV GO:0006749 1/101 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG89CSNV GO:0016021 1/101 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89CSNV GO:0048471 1/101 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG89CSNN GO:0005524 1/19 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89CSNN GO:0017111 1/19 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8D55C3 GO:0003676 2/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83V2F4 GO:0016021 1/2 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83V2F4 GO:0055085 1/2 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG83V2F4 GO:0005215 1/2 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG866Z44 GO:0004871 24/133 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG866Z44 GO:0006351 20/133 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG866Z44 GO:0006355 20/133 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0005634 20/133 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG866Z44 GO:0003677 19/133 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG866Z44 GO:0003678 5/133 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG866Z44 GO:0006281 5/133 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG866Z44 GO:0000723 5/133 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG866Z44 GO:0005524 2/133 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG866Z44 GO:0045944 1/133 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0035147 1/133 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG866Z44 GO:0006357 1/133 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG866Z44 GO:0043565 1/133 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG866Z44 GO:0007427 1/133 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG866Z44 GO:0046982 1/133 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG866Z44 GO:0043234 1/133 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG866Z44 GO:0003700 1/133 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8J6V67 GO:0043190 1/6 ATP-binding cassette (ABC) transporter complex cellular_component "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] EOG8J6V67 GO:0015417 1/6 polyamine-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] EOG8J6V67 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D55CK GO:0008270 22/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D55CK GO:0035556 3/94 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8D55CK GO:0070822 1/94 Sin3-type complex cellular_component "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] EOG8D55CJ GO:0008532 5/138 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] EOG8D55CJ GO:0016740 3/138 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8D55CJ GO:0005506 1/138 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8D55CJ GO:0007218 1/138 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8D55CJ GO:0002121 1/138 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8D55CJ GO:0008109 1/138 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] EOG8D55CJ GO:0020037 1/138 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8D55CJ GO:0016705 1/138 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8D55CM GO:0005576 40/210 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8D55CM GO:0005578 2/210 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8D55CM GO:0007411 2/210 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8D55CM GO:0008045 2/210 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8D55CM GO:2000289 2/210 regulation of photoreceptor cell axon guidance biological_process "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah] EOG8D55CM GO:0070983 2/210 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8D55CM GO:0008347 2/210 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8D55CM GO:0016021 1/210 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D55CM GO:0005515 1/210 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D55CM GO:0016200 1/210 synaptic target attraction biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] EOG8D55CM GO:0008039 1/210 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8D55CM GO:0055085 1/210 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8D55CM GO:0007432 1/210 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG8W10SX GO:0005524 13/74 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8W10SX GO:0003676 13/74 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W10SX GO:0008026 11/74 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8W10SX GO:0004386 2/74 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG88PQ1J GO:0016740 2/6 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG88PQ1J GO:0005524 2/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88PQ1J GO:0008033 2/6 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG88PQ1J GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88PQ1J GO:0007049 1/6 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8H74RX GO:0004842 17/55 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8H74RX GO:0000151 17/55 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG8H74RX GO:0008270 2/55 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H74RX GO:0006412 1/55 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8H74RX GO:0005840 1/55 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8H74RX GO:0003735 1/55 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG84J4ZX GO:0046872 52/224 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84J4ZX GO:0016787 45/224 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG84J4ZX GO:0004177 13/224 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG84J4ZX GO:0005829 1/224 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84J4ZX GO:0006508 1/224 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG84J4ZX GO:0022008 1/224 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84J4ZX GO:0070006 1/224 metalloaminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG84J4ZW GO:0016021 7/20 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84J4ZW GO:0006885 4/20 regulation of pH biological_process "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG84J4ZW GO:0015385 4/20 sodium:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] EOG84J4ZW GO:0015299 3/20 solute:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] EOG84J4ZT GO:0006909 1/84 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84J4ZT GO:0005884 1/84 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG84J4ZT GO:0005737 1/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84J4ZT GO:0016021 1/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84J4ZT GO:0003779 1/84 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG84J4ZT GO:0005829 1/84 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84J4ZT GO:0030041 1/84 actin filament polymerization biological_process "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG84J4ZT GO:0005576 1/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG84J4ZT GO:0046872 1/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84J4ZT GO:0005215 1/84 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8N06WM GO:0004252 1/12 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG84J4ZP GO:0016020 25/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VHNQ9 GO:0006810 1/3 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8VHNQ9 GO:0030288 1/3 outer membrane-bounded periplasmic space cellular_component "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu] EOG8H74RF GO:0005524 1/37 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H74RF GO:0004674 1/37 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8H74RF GO:0008270 1/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VHNQ3 GO:0005230 4/24 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8VHNQ3 GO:0016021 4/24 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FTZDC GO:0008270 20/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZDC GO:0051371 3/93 muscle alpha-actinin binding molecular_function "Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] EOG8FTZDC GO:0001952 3/93 regulation of cell-matrix adhesion biological_process "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] EOG8FTZDC GO:0015629 3/93 actin cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] EOG8FTZDC GO:0030018 1/93 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8FTZDC GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FTZDC GO:0003779 1/93 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8FTZDC GO:0005927 1/93 muscle tendon junction cellular_component "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] EOG8FTZDC GO:0030239 1/93 myofibril assembly biological_process "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] EOG8FTZDC GO:0061061 1/93 muscle structure development biological_process "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] EOG8V71XF GO:0005524 27/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V71XF GO:0017111 24/90 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8V71XF GO:0008568 3/90 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8V71XF GO:0005813 1/90 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8V71XF GO:0016787 1/90 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8V71XF GO:0046034 1/90 ATP metabolic process biological_process "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] EOG8V71XF GO:0005694 1/90 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8V71XF GO:0000287 1/90 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8V71XF GO:0036078 1/90 minus-end specific microtubule depolymerization biological_process "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528] EOG8V71XF GO:0000070 1/90 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8V71XF GO:0006200 1/90 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8V71XF GO:0051013 1/90 microtubule severing biological_process "The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234] EOG86T5F8 GO:0003777 25/103 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG86T5F8 GO:0005871 25/103 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG86T5F8 GO:0007018 25/103 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG86T5F8 GO:0005524 25/103 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86T5F8 GO:0005874 21/103 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG86T5F8 GO:0005737 2/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86T5F8 GO:0048812 1/103 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8Z0DPG GO:0016772 1/18 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Z0DPG GO:0016301 1/18 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8T7BJT GO:0005524 13/41 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T7BJT GO:0004674 12/41 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8T7BJT GO:0004683 1/41 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG805VGZ GO:0003676 1/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG805VGZ GO:0004523 1/10 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8KSS27 GO:0016905 1/5 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG8V71XK GO:0016998 2/8 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8Z0DPP GO:0016998 5/10 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8Z0DPP GO:0003796 5/10 lysozyme activity molecular_function "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] EOG8Z0DPP GO:0009253 5/10 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8V71XQ GO:0004190 2/10 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8FTZDZ GO:0003677 24/147 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FTZDZ GO:0005634 2/147 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FTZDZ GO:0045197 1/147 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8FTZDZ GO:0007427 1/147 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0007428 1/147 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8FTZDZ GO:0006355 1/147 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8FTZDZ GO:0035297 1/147 regulation of Malpighian tubule diameter biological_process "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] EOG8FTZDZ GO:0007442 1/147 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG8FTZDZ GO:0016477 1/147 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8FTZDZ GO:0008258 1/147 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8FTZDZ GO:0007426 1/147 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0003700 1/147 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FTZDZ GO:0007010 1/147 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8FTZDZ GO:0007424 1/147 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8FTZDZ GO:0007431 1/147 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8FTZDZ GO:0007443 1/147 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8FTZDZ GO:0035149 1/147 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG8FTZDZ GO:0008360 1/147 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FTZDZ GO:0003676 1/147 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZDZ GO:0046872 1/147 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FTZDZ GO:0007417 1/147 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8FTZDZ GO:0007391 1/147 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FTZDZ GO:0061024 1/147 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8FTZDZ GO:0008104 1/147 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8FTZDZ GO:0007435 1/147 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8FTZDZ GO:0008406 1/147 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8S1WMX GO:0016772 29/143 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8V19FP GO:0016021 24/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V19FP GO:0005216 23/98 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8V19FP GO:0070588 1/98 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8V19FP GO:0001964 1/98 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8V19FP GO:0048148 1/98 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG8V19FP GO:0040040 1/98 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8V19FP GO:0007605 1/98 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8V19FP GO:0010996 1/98 response to auditory stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] EOG8V19FP GO:0043052 1/98 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8V19FP GO:0007608 1/98 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8V19FP GO:0007629 1/98 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8V19FP GO:0009408 1/98 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8V19FP GO:0048060 1/98 negative gravitaxis biological_process "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] EOG8V19FP GO:0006816 1/98 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8V19FP GO:0005262 1/98 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8ZKN2V GO:0035091 2/15 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG8ZKN2V GO:0016301 1/15 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8ZKN2P GO:0006783 1/7 heme biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] EOG8ZKN2P GO:0004325 1/7 ferrochelatase activity molecular_function "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587] EOG84J527 GO:0003676 1/17 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GJZ GO:0016021 1/188 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG883GJZ GO:0006909 1/188 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8ZKN28 GO:0008168 24/162 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8ZKN28 GO:0030798 11/162 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG8ZKN25 GO:0008168 1/8 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8V19F3 GO:0007522 1/69 visceral muscle development biological_process "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] EOG8V19F3 GO:0007435 1/69 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8V19F3 GO:0005576 1/69 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V19F3 GO:0007411 1/69 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8V19F3 GO:0007171 1/69 activation of transmembrane receptor protein tyrosine kinase activity biological_process "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] EOG8V19F3 GO:0061176 1/69 type Ib terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc] EOG8V19F3 GO:0061177 1/69 type Is terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc] EOG8V19F3 GO:0051124 1/69 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8V19F3 GO:0005615 1/69 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8V19F3 GO:0008021 1/69 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8V19F3 GO:0007509 1/69 mesoderm migration involved in gastrulation biological_process "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] EOG8V19F3 GO:1900074 1/69 negative regulation of neuromuscular synaptic transmission biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG8V19F3 GO:0042051 1/69 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG8V19F3 GO:0043410 1/69 positive regulation of MAPK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] EOG8V19F3 GO:0030297 1/69 transmembrane receptor protein tyrosine kinase activator activity molecular_function "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] EOG8V19F3 GO:0042694 1/69 muscle cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] EOG8V19F7 GO:0050660 31/102 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8V19F7 GO:0008762 30/102 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG8V19F7 GO:0004458 2/102 D-lactate dehydrogenase (cytochrome) activity molecular_function "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] EOG8V19F7 GO:0003824 1/102 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG88WFGK GO:0004056 22/73 argininosuccinate lyase activity molecular_function "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] EOG88WFGK GO:0042450 22/73 arginine biosynthetic process via ornithine biological_process "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl] EOG88WFGK GO:0005524 2/73 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88WFGK GO:0016887 2/73 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG88WFGK GO:0016020 1/73 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88WFGK GO:0005215 1/73 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG805VG7 GO:0005506 679/2000 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG805VG7 GO:0020037 679/2000 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG805VG7 GO:0016705 629/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG805VG7 GO:0004497 607/2000 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG805VG7 GO:0070330 31/2000 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG805VG7 GO:0005789 25/2000 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG805VG7 GO:0050591 15/2000 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG805VG7 GO:0004796 4/2000 thromboxane-A synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140] EOG805VG7 GO:0031000 2/2000 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG805VG7 GO:0009055 2/2000 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG805VG7 GO:0016712 2/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG805VG7 GO:0017085 2/2000 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG805VG7 GO:0006697 1/2000 ecdysone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] EOG805VG7 GO:0050829 1/2000 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG805VG7 GO:0030178 1/2000 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG805VG7 GO:0017143 1/2000 insecticide metabolic process biological_process "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0046701 1/2000 insecticide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0022416 1/2000 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG805VG7 GO:0042742 1/2000 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG805VG7 GO:0048252 1/2000 lauric acid metabolic process biological_process "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid] EOG805VG7 GO:0016020 1/2000 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VG7 GO:1901563 1/2000 response to camptothecin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] EOG805VG7 GO:0018685 1/2000 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG805VG7 GO:0033777 1/2000 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG805VG7 GO:0002118 1/2000 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG805VG7 GO:0046683 1/2000 response to organophosphorus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] EOG805VG7 GO:0035220 1/2000 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG805VG7 GO:0048638 1/2000 regulation of developmental growth biological_process "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] EOG805VG7 GO:0040040 1/2000 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG805VG7 GO:0046680 1/2000 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG805VG7 GO:0046689 1/2000 response to mercury ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] EOG86T5FR GO:0003677 24/90 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86T5FR GO:0016491 24/90 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG86T5FR GO:0050660 20/90 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG86T5FR GO:0034720 20/90 histone H3-K4 demethylation biological_process "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah] EOG86T5FR GO:0005634 20/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86T5FR GO:0006355 20/90 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86T5FR GO:0008168 5/90 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG86T5FR GO:0046592 2/90 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG86T5FR GO:0006351 1/90 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86T5FR GO:0006325 1/90 chromatin organization biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] EOG86T5FR GO:0008593 1/90 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG86T5FR GO:0070828 1/90 heterochromatin organization biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] EOG86T5FR GO:0017053 1/90 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG86T5FR GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86T5FR GO:0007474 1/90 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG86T5FR GO:0005694 1/90 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG86T5FR GO:0048477 1/90 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG86T5FR GO:0016458 1/90 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG85QKVJ GO:0046872 6/14 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85QKVJ GO:0042732 6/14 D-xylose metabolic process biological_process "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] EOG85QKVJ GO:0009045 6/14 xylose isomerase activity molecular_function "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] EOG85QKVJ GO:0006098 6/14 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG85QKVJ GO:0030246 1/14 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG85QKVJ GO:0003700 1/14 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85QKVJ GO:0003677 1/14 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG805VG9 GO:0004140 24/80 dephospho-CoA kinase activity molecular_function "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18248] EOG805VG9 GO:0015937 24/80 coenzyme A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] EOG805VG9 GO:0005524 24/80 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KSS2H GO:0003677 2/6 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8KSS2H GO:0003700 2/6 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8KSS2H GO:0000156 1/6 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8V71X1 GO:0004185 56/160 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8V71X1 GO:0005576 1/160 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V71X1 GO:0033227 1/160 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8QC3MN GO:0030246 46/187 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8QC3MN GO:0006810 2/187 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8QC3MN GO:0016021 2/187 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QC3MN GO:0016020 1/187 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QC3MN GO:0008233 1/187 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8WHC2P GO:0008080 6/57 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8J6V5F GO:0004649 27/84 poly(ADP-ribose) glycohydrolase activity molecular_function "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] EOG8J6V5F GO:0005975 27/84 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8J6V5F GO:0006909 1/84 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8J6V5F GO:0005634 1/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J6V5F GO:0036099 1/84 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG8J6V5F GO:0006342 1/84 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8J6V5F GO:0035065 1/84 regulation of histone acetylation biological_process "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] EOG8J6V5F GO:0051457 1/84 maintenance of protein location in nucleus biological_process "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] EOG8J6V5F GO:0005654 1/84 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8J6V5F GO:0030576 1/84 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG8J6V5F GO:0009408 1/84 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8J6V5F GO:0043484 1/84 regulation of RNA splicing biological_process "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] EOG8J6V5C GO:0006799 1/7 polyphosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732] EOG8J6V5C GO:0009358 1/7 polyphosphate kinase complex cellular_component "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] EOG8J6V5C GO:0008976 1/7 polyphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] EOG8J6V5N GO:0016747 1/8 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8V45RT GO:0003676 4/35 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J6V5R GO:0003676 8/63 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J6V5R GO:0015074 7/63 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8J6V5R GO:0005634 2/63 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DJN9T GO:0005272 31/100 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8DJN9T GO:0016021 27/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DJN9T GO:0016020 4/100 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DJN9T GO:0008049 1/100 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8DJN9T GO:0019236 1/100 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8DJN9T GO:0002121 1/100 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8C8B6T GO:0003723 1/13 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8PP0Z6 GO:0003979 2/5 UDP-glucose 6-dehydrogenase activity molecular_function "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23599] EOG8PP0Z6 GO:0000271 2/5 polysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] EOG8PP0Z6 GO:0051287 2/5 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8DBWV5 GO:0003824 1/4 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8DBWV7 GO:0016491 22/94 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8DBWV7 GO:0047545 2/94 2-hydroxyglutarate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] EOG8DBWV7 GO:0005811 1/94 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8DBWV0 GO:0005856 25/104 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8DBWV0 GO:0019898 24/104 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8DBWV0 GO:0005737 24/104 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DBWV0 GO:0008092 1/104 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG8B5RKS GO:0004185 64/157 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8642T8 GO:0005975 1/10 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8642T8 GO:0016857 1/10 racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] EOG8P8J15 GO:0007218 6/46 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8P8J15 GO:0005576 3/46 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8P8J15 GO:0040014 3/46 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8P8J15 GO:0032095 3/46 regulation of response to food biological_process "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] EOG8P8J15 GO:0005184 3/46 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8P8J15 GO:0045793 1/46 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8P8J15 GO:0007623 1/46 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8P8J15 GO:0007186 1/46 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8P8J15 GO:0035177 1/46 larval foraging behavior biological_process "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] EOG8P8J15 GO:0040018 1/46 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P8J15 GO:0090062 1/46 regulation of trehalose metabolic process biological_process "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb] EOG8P8J15 GO:0005615 1/46 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8P8J15 GO:0046628 1/46 positive regulation of insulin receptor signaling pathway biological_process "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8P8J15 GO:0048512 1/46 circadian behavior biological_process "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] EOG8P8J15 GO:0070374 1/46 positive regulation of ERK1 and ERK2 cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah] EOG8P8J15 GO:0043025 1/46 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8P8J15 GO:0005179 1/46 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG8P8J15 GO:0071859 1/46 neuropeptide F receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah] EOG8P8J15 GO:0008343 1/46 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG8P8J15 GO:0030424 1/46 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8P8J15 GO:0008049 1/46 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8P8J15 GO:0030536 1/46 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8P8J15 GO:0010906 1/46 regulation of glucose metabolic process biological_process "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] EOG8P8J15 GO:0071855 1/46 neuropeptide receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] EOG8P8J15 GO:0035264 1/46 multicellular organism growth biological_process "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] EOG8P8J15 GO:0008340 1/46 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8P8J15 GO:0045475 1/46 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8P8J15 GO:0008345 1/46 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8QVFVQ GO:0045263 2/22 proton-transporting ATP synthase complex, coupling factor F(o) cellular_component "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] EOG8QVFVQ GO:0046716 1/22 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8QVFVQ GO:0008340 1/22 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8QVFVQ GO:0005739 1/22 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8QVFVQ GO:0046933 1/22 proton-transporting ATP synthase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] EOG8QVFVQ GO:0005743 1/22 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8QVFVQ GO:0015992 1/22 proton transport biological_process "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG8QVFVQ GO:0008553 1/22 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] EOG8QVFVQ GO:0016021 1/22 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QVFVQ GO:0015078 1/22 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8QVFVQ GO:0040011 1/22 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8QVFVQ GO:0042776 1/22 mitochondrial ATP synthesis coupled proton transport biological_process "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] EOG8QVFVQ GO:0015986 1/22 ATP synthesis coupled proton transport biological_process "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] EOG8QVFVQ GO:0070050 1/22 neuron cellular homeostasis biological_process "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] EOG8B5RKB GO:0004683 23/137 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8B5RKB GO:0005524 23/137 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8B5RKB GO:0004674 2/137 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8B5RKB GO:0005954 2/137 calcium- and calmodulin-dependent protein kinase complex cellular_component "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] EOG8B5RKB GO:0060278 1/137 regulation of ovulation biological_process "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] EOG8B5RKB GO:0008049 1/137 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8B5RKB GO:0005515 1/137 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8B5RKB GO:0006468 1/137 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8B5RKB GO:0005516 1/137 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8B5RKB GO:0007616 1/137 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8B5RKB GO:0051489 1/137 regulation of filopodium assembly biological_process "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG8B5RKB GO:0007528 1/137 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8B5RKB GO:0005886 1/137 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8B5RKB GO:0048786 1/137 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8B5RKB GO:0030424 1/137 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8B5RKB GO:0007268 1/137 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8B5RKB GO:0007619 1/137 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8B5RKB GO:0008582 1/137 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8B5RKB GO:0045211 1/137 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8B5RKB GO:0007611 1/137 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8B5RKB GO:0030425 1/137 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8B5RKC GO:0005525 26/96 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8B5RKC GO:0003924 26/96 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8B5RKC GO:0045727 24/96 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG8B5RKC GO:0005759 24/96 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8B5RKC GO:0006412 24/96 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8B5RKC GO:0005743 24/96 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8B5RKC GO:0043022 24/96 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8B5RKC GO:0008831 1/96 dTDP-4-dehydrorhamnose reductase activity molecular_function "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799] EOG8B5RKC GO:0045226 1/96 extracellular polysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] EOG8NZXBH GO:0003676 1/3 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JWXVZ GO:0003677 3/13 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JWXVZ GO:0003676 1/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MPM40 GO:0005525 24/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8MPM40 GO:0003924 23/90 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8MPM40 GO:0003746 2/90 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8MPM40 GO:0005682 1/90 U5 snRNP cellular_component "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] EOG8MPM40 GO:0071011 1/90 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8MPM40 GO:0019013 1/90 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8MPM40 GO:0006414 1/90 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8MPM40 GO:0030529 1/90 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8MPM40 GO:0030532 1/90 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8MPM40 GO:0071013 1/90 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8MPM40 GO:0000398 1/90 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8MPM40 GO:0005829 1/90 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG81K1SR GO:0008270 44/198 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1SR GO:0043154 1/198 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0007423 1/198 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG81K1SR GO:0004842 1/198 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81K1SR GO:0003677 1/198 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81K1SR GO:0007289 1/198 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG81K1SR GO:0007283 1/198 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG81K1SR GO:0019788 1/198 NEDD8 transferase activity molecular_function "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] EOG81K1SR GO:0005737 1/198 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81K1SR GO:0007298 1/198 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG81K1SR GO:0051865 1/198 protein autoubiquitination biological_process "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] EOG81K1SR GO:0006352 1/198 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG81K1SR GO:0008407 1/198 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG81K1SR GO:0009987 1/198 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG81K1SR GO:0007275 1/198 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81K1SR GO:0008354 1/198 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG81K1SR GO:0045035 1/198 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG81K1SR GO:0048800 1/198 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG81K1SR GO:1990001 1/198 inhibition of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137] EOG81K1SR GO:0005634 1/198 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81K1SR GO:0005515 1/198 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81K1SR GO:0046673 1/198 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG81K1SR GO:0031398 1/198 positive regulation of protein ubiquitination biological_process "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] EOG81K1SR GO:0016055 1/198 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG81K1SR GO:0097340 1/198 inhibition of cysteine-type endopeptidase activity biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739] EOG81K1SR GO:0019899 1/198 enzyme binding molecular_function "Interacting selectively and non-covalently with any enzyme." [GOC:jl] EOG81K1SR GO:0090263 1/198 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG81K1SR GO:0043066 1/198 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0042787 1/198 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG81K1SR GO:0006915 1/198 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG81K1SR GO:0004869 1/198 cysteine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] EOG81K1SS GO:0007476 1/91 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG81K1SS GO:0048149 1/91 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG81K1SS GO:0048865 1/91 stem cell fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] EOG81K1SS GO:0007601 1/91 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG81K1SS GO:0042461 1/91 photoreceptor cell development biological_process "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] EOG81K1SS GO:0001751 1/91 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG81K1SS GO:0097038 1/91 perinuclear endoplasmic reticulum cellular_component "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] EOG81K1SS GO:0007421 1/91 stomatogastric nervous system development biological_process "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] EOG81K1SS GO:0005794 1/91 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG81K1SS GO:0007173 1/91 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG81K1SS GO:0005789 1/91 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG81K1SS GO:0005886 1/91 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81K1SS GO:0035225 1/91 determination of genital disc primordium biological_process "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] EOG81K1SS GO:0000139 1/91 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG81K1SS GO:0042058 1/91 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG81K1SS GO:0048477 1/91 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG81K1SS GO:0061331 1/91 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG81K1SS GO:0016318 1/91 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG81K1SS GO:0046667 1/91 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG81K1SS GO:0000042 1/91 protein targeting to Golgi biological_process "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] EOG81K1SS GO:0007422 1/91 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG81K1SS GO:0007498 1/91 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG81K1SS GO:0038004 1/91 epidermal growth factor receptor ligand maturation biological_process "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524] EOG81K1SS GO:0016021 1/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81K1SS GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81K1SS GO:0005783 1/91 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG81K1SS GO:0046845 1/91 branched duct epithelial cell fate determination, open tracheal system biological_process "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] EOG8B5RK6 GO:0006355 6/47 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8B5RK6 GO:0005634 6/47 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8B5RK6 GO:0004402 2/47 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8B5RK0 GO:0005622 12/79 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8B5RK0 GO:0008270 12/79 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B5RK1 GO:0005634 27/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8B5RK1 GO:0006886 21/102 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8B5RK1 GO:0006810 4/102 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8B5RK1 GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8B5RK1 GO:0035048 1/102 splicing factor protein import into nucleus biological_process "The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf] EOG8B5RK1 GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B5RK1 GO:0006606 1/102 protein import into nucleus biological_process "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] EOG8B5RK1 GO:0048024 1/102 regulation of mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] EOG8B5RK1 GO:0022008 1/102 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8B5RK9 GO:0000166 24/84 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8B5RK9 GO:0003676 23/84 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B5RK9 GO:0005515 1/84 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8B5RK9 GO:0045451 1/84 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8B5RK9 GO:0007315 1/84 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8B5RK9 GO:0008298 1/84 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8B5RK9 GO:0048477 1/84 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8B5RK9 GO:0008270 1/84 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B5RK9 GO:0048134 1/84 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG8B5RK9 GO:0046011 1/84 regulation of oskar mRNA translation biological_process "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] EOG8B5RK9 GO:0005737 1/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B5RK9 GO:0046012 1/84 positive regulation of oskar mRNA translation biological_process "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators] EOG8B5RK9 GO:0007294 1/84 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8B5RK9 GO:0007309 1/84 oocyte axis specification biological_process "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8B5RK9 GO:0007281 1/84 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8B5RK9 GO:0005622 1/84 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8B5RK9 GO:0007314 1/84 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8B5RK9 GO:0006378 1/84 mRNA polyadenylation biological_process "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] EOG8B5RK9 GO:0045727 1/84 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG8B5RK9 GO:0000578 1/84 embryonic axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] EOG8B5RK9 GO:0007310 1/84 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8B5RK9 GO:0003729 1/84 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG81K1S4 GO:0008270 26/90 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1S4 GO:0004842 23/90 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81K1S4 GO:0007520 1/90 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG81K1S4 GO:0004623 1/90 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG81K1S4 GO:0032038 1/90 myosin II heavy chain binding molecular_function "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah] EOG81K1S4 GO:0046872 1/90 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81K1S4 GO:0031430 1/90 M band cellular_component "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] EOG81K1S4 GO:0030018 1/90 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG81K1S4 GO:0032033 1/90 myosin II light chain binding molecular_function "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah] EOG81K1S4 GO:0046716 1/90 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG81K1S4 GO:0005737 1/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VX4M0 GO:0008270 76/1021 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VX4M0 GO:0003676 72/1021 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VX4M0 GO:0003964 70/1021 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VX4M0 GO:0015074 70/1021 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8VX4M0 GO:0003723 69/1021 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VX4M0 GO:0005198 14/1021 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8VX4M0 GO:0005882 14/1021 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8VX4M0 GO:0004190 10/1021 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8VX4M0 GO:0003677 4/1021 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4M0 GO:0005634 2/1021 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WHC22 GO:0005615 1/51 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8WHC22 GO:0032504 1/51 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8KWN9X GO:0004190 7/59 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8KWN9X GO:0003676 1/59 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WHC29 GO:0016021 24/126 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WHC29 GO:0007517 24/126 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8WHC29 GO:0016012 24/126 sarcoglycan complex cellular_component "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] EOG8WHC29 GO:0005882 1/126 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8WHC29 GO:0005198 1/126 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8WHC29 GO:0008270 1/126 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83BQ4K GO:0016021 22/111 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83BQ4K GO:0004930 22/111 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG83BQ4K GO:0007472 1/111 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG83BQ4K GO:0007476 1/111 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG83BQ4K GO:0007186 1/111 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG83BQ4K GO:0005886 1/111 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG83BQ4K GO:0007509 1/111 mesoderm migration involved in gastrulation biological_process "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] EOG83BQ4K GO:0070252 1/111 actin-mediated cell contraction biological_process "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] EOG83BQ4K GO:0008340 1/111 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG83BQ4K GO:0007369 1/111 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG83BQ4K GO:0042594 1/111 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8J6V56 GO:0043161 1/92 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG8J6V56 GO:0006289 1/92 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8J6V56 GO:0003684 1/92 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8J6V56 GO:0070628 1/92 proteasome binding molecular_function "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] EOG8J6V56 GO:0042982 1/92 amyloid precursor protein metabolic process biological_process "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] EOG8J6V56 GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8J6V51 GO:0004372 2/16 glycine hydroxymethyltransferase activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] EOG8J6V51 GO:0006544 2/16 glycine metabolic process biological_process "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] EOG8J6V51 GO:0030170 2/16 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8J6V51 GO:0035999 2/16 tetrahydrofolate interconversion biological_process "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] EOG8J6V51 GO:0006563 2/16 L-serine metabolic process biological_process "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] EOG8J6V51 GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J6V51 GO:0055085 1/16 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8J6V51 GO:0008168 1/16 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8PP0ZR GO:0005576 4/20 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PP0ZR GO:0007218 1/20 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8QRKK2 GO:0008146 88/156 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QRKK2 GO:0016021 87/156 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QRKK2 GO:0009950 1/156 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8QRKK2 GO:0016485 1/156 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8QRKK2 GO:0030173 1/156 integral component of Golgi membrane cellular_component "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] EOG8QRKK2 GO:0008063 1/156 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8QRKK2 GO:0005694 1/156 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8QRKK2 GO:0048477 1/156 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8QRKK2 GO:0040014 1/156 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8QRKK2 GO:0005794 1/156 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8QRKK2 GO:0007313 1/156 maternal specification of dorsal/ventral axis, oocyte, soma encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8QRKK2 GO:0004394 1/156 heparan sulfate 2-O-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] EOG8QRKK2 GO:0009880 1/156 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8QRKK2 GO:0005634 1/156 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QRKK2 GO:0005515 1/156 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WDGV7 GO:0042302 184/825 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8WDGV7 GO:0040003 5/825 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8WDGV7 GO:0031012 5/825 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8WDGV7 GO:0008010 5/825 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8WDGV7 GO:0022008 1/825 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8VT8C5 GO:0009378 2/13 four-way junction helicase activity molecular_function "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] EOG8VT8C5 GO:0006310 2/13 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8VT8C5 GO:0006281 2/13 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8VT8C5 GO:0005524 2/13 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VT8C5 GO:0003677 2/13 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83FKB6 GO:0016021 17/49 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83FKB6 GO:0015171 17/49 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG89GP1V GO:0005975 1/3 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG89GP1V GO:0004553 1/3 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG812PNT GO:0030785 1/31 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] EOG8RBT3B GO:0005525 1/2 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8RBT3B GO:0003924 1/2 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8DV812 GO:0005643 30/119 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8DV812 GO:0006810 29/119 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8DV812 GO:0006909 1/119 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8DV812 GO:0007184 1/119 SMAD protein import into nucleus biological_process "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] EOG8DV812 GO:0030718 1/119 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8DV812 GO:0005515 1/119 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8T1M2J GO:0016788 2/29 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8T1M2J GO:0003676 2/29 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M2J GO:0010529 1/29 negative regulation of transposition biological_process "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] EOG8T1M2J GO:0043186 1/29 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8T1M2J GO:0030717 1/29 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8DV816 GO:0003676 2/32 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DV816 GO:0000166 2/32 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8DV815 GO:0018738 19/140 S-formylglutathione hydrolase activity molecular_function "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964] EOG8DV815 GO:0046294 19/140 formaldehyde catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] EOG8DV815 GO:0052689 2/140 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8T1M2G GO:0003676 3/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M2G GO:0046872 3/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DV819 GO:0005524 21/84 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DV819 GO:0004674 20/84 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8DV819 GO:0004672 2/84 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8DV819 GO:0007274 1/84 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8DV819 GO:0043069 1/84 negative regulation of programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8DV819 GO:0006979 1/84 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8DV819 GO:0005739 1/84 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DV819 GO:0010821 1/84 regulation of mitochondrion organization biological_process "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] EOG8DV819 GO:0000266 1/84 mitochondrial fission biological_process "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] EOG8DV819 GO:0005515 1/84 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DV819 GO:0030382 1/84 sperm mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] EOG8DV819 GO:0035234 1/84 ectopic germ cell programmed cell death biological_process "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] EOG8DV819 GO:0007005 1/84 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8DV819 GO:0000422 1/84 mitophagy biological_process "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] EOG8DV819 GO:0090141 1/84 positive regulation of mitochondrial fission biological_process "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8DV819 GO:0048749 1/84 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8DV819 GO:0042787 1/84 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8DV819 GO:0005737 1/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DV819 GO:0010637 1/84 negative regulation of mitochondrial fusion biological_process "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] EOG8DV819 GO:0043524 1/84 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8DV819 GO:0016006 1/84 Nebenkern cellular_component "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] EOG8DV819 GO:0048078 1/84 positive regulation of compound eye pigmentation biological_process "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG80306B GO:0005524 24/86 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80306B GO:0017111 22/86 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG80306B GO:0008568 1/86 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG80306B GO:0007031 1/86 peroxisome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] EOG8T1M2C GO:0005737 24/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T1M2C GO:0008033 23/90 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8T1M2C GO:0016783 22/90 sulfurtransferase activity molecular_function "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] EOG8T1M2C GO:0008168 3/90 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8T1M2C GO:0004808 2/90 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] EOG8T1M2C GO:0000049 1/90 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG8T1M2C GO:0016740 1/90 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8T1M2C GO:0005739 1/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8T1M2C GO:0005524 1/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81VNJS GO:0005525 12/48 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG81VNJS GO:0007264 12/48 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8NGK30 GO:0016491 28/91 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8NGK30 GO:0050221 1/91 prostaglandin-E2 9-reductase activity molecular_function "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] EOG803085 GO:0003676 2/11 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG803085 GO:0046872 2/11 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG803085 GO:0008270 2/11 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H1D8X GO:0016301 2/101 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8H1D8X GO:0007424 1/101 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8H1D8X GO:0005918 1/101 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8H1D8X GO:0016328 1/101 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG8H1D8X GO:0035001 1/101 dorsal trunk growth, open tracheal system biological_process "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] EOG8H1D8X GO:0035159 1/101 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG8H1D8X GO:0035151 1/101 regulation of tube size, open tracheal system biological_process "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] EOG8H1D8X GO:0019991 1/101 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8T1M2V GO:0005634 43/158 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8T1M2V GO:0003677 43/158 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8T1M2V GO:0006355 41/158 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8T1M2V GO:0006351 41/158 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8T1M2V GO:0045892 2/158 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8T1M2V GO:0005515 2/158 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8T1M2V GO:0000122 2/158 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8T1M2V GO:0001078 2/158 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8T1M2V GO:0007366 2/158 periodic partitioning by pair rule gene biological_process "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8T1M2V GO:0000902 1/158 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8T1M2V GO:0031323 1/158 regulation of cellular metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] EOG8T1M2V GO:0007460 1/158 R8 cell fate commitment biological_process "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG8T1M2V GO:0007530 1/158 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG8T1M2V GO:0001666 1/158 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8T1M2V GO:0000978 1/158 RNA polymerase II core promoter proximal region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] EOG8T1M2V GO:0008345 1/158 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8T1M2V GO:0007549 1/158 dosage compensation biological_process "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] EOG8T1M2V GO:0048813 1/158 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8T1M2V GO:0008134 1/158 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8T1M2V GO:0070888 1/158 E-box binding molecular_function "Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799] EOG8T1M2V GO:0035239 1/158 tube morphogenesis biological_process "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] EOG8T1M2V GO:0007540 1/158 sex determination, establishment of X:A ratio biological_process "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete] EOG8T1M2V GO:0007424 1/158 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8T1M2V GO:0007431 1/158 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8T1M2V GO:0007435 1/158 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8T1M2V GO:0035289 1/158 posterior head segmentation biological_process "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] EOG8T1M2V GO:0061024 1/158 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8T1M2V GO:0035290 1/158 trunk segmentation biological_process "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] EOG8T1M2V GO:0008344 1/158 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8T1M2V GO:0007219 1/158 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8T1M2V GO:0002052 1/158 positive regulation of neuroblast proliferation biological_process "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] EOG80306S GO:0008270 1/116 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D2950 GO:0003723 24/121 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D2950 GO:0004000 23/121 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8D2950 GO:0006396 23/121 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8D2950 GO:0016491 9/121 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D2950 GO:0004032 2/121 alditol:NADP+ 1-oxidoreductase activity molecular_function "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] EOG8D2950 GO:0046872 1/121 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D2950 GO:0006400 1/121 tRNA modification biological_process "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] EOG8D2950 GO:0008251 1/121 tRNA-specific adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] EOG8D2950 GO:0008033 1/121 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG80306V GO:0008270 329/890 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80306V GO:0004181 329/890 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG80306V GO:0005319 8/890 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG80306V GO:0005615 3/890 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80306V GO:0007586 1/890 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG80306V GO:0022008 1/890 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG80306V GO:0031982 1/890 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG80306V GO:0004180 1/890 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG80306V GO:0005515 1/890 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80306V GO:0005576 1/890 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80306V GO:0016021 1/890 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80306V GO:0004930 1/890 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DV81R GO:0016192 2/15 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8DV81R GO:0016021 2/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DV81P GO:0005794 77/199 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8DV81P GO:0016021 77/199 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DV81P GO:0006486 77/199 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8DV81P GO:0008378 68/199 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8DV81P GO:0047915 9/199 ganglioside galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] EOG8DV81P GO:0008039 1/199 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8DV81P GO:0007030 1/199 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8D295H GO:0004422 3/17 hypoxanthine phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] EOG8D295H GO:0006166 2/17 purine ribonucleoside salvage biological_process "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] EOG8D295H GO:0005737 2/17 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D295H GO:0016491 1/17 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D295H GO:0005507 1/17 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8D295H GO:0009116 1/17 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8D295H GO:0016740 1/17 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8D295H GO:0052657 1/17 guanine phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] EOG8DV81Z GO:0005524 9/42 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DV81Z GO:0004674 7/42 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8DV81Z GO:0004672 1/42 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8DV81Z GO:0004683 1/42 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8ZCWQ5 GO:0016811 1/2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG8DV81C GO:0016740 2/140 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8D295V GO:0004852 32/94 uroporphyrinogen-III synthase activity molecular_function "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968] EOG8D295V GO:0033014 32/94 tetrapyrrole biosynthetic process biological_process "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] EOG8935ZQ GO:0008234 56/92 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8935ZQ GO:0005576 2/92 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8935ZQ GO:0032504 1/92 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8935ZQ GO:0006508 1/92 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8935ZQ GO:0006030 1/92 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8935ZQ GO:0008061 1/92 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8935ZQ GO:0005615 1/92 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8935ZP GO:0005524 7/35 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8935ZP GO:0004674 6/35 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8935ZP GO:0004693 1/35 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8935ZM GO:0003676 1/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NZX9F GO:0022904 25/88 respiratory electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] EOG8NZX9F GO:0005743 25/88 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8NZX9F GO:0016651 22/88 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8NZX9F GO:0008137 3/88 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG84TRPN GO:0007154 3/8 cell communication biological_process "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] EOG84TRPN GO:0016021 3/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HDW7P GO:0008017 1/94 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8HDW7P GO:0007017 1/94 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8HDW7P GO:0005875 1/94 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8HDW7P GO:0008152 1/94 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8D55BK GO:0005524 25/102 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D55BK GO:0004674 24/102 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8D55BK GO:0007165 23/102 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8D55BK GO:0004697 2/102 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8D55BK GO:0006468 1/102 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8D55BK GO:0016301 1/102 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8D55BK GO:0046777 1/102 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG8D55BK GO:0030054 1/102 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8D55BK GO:0090303 1/102 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8D55BK GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D55BK GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55BK GO:0016020 1/102 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8D55BK GO:0032154 1/102 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8D55BK GO:0030027 1/102 lamellipodium cellular_component "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] EOG8D55BK GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D55BK GO:0030496 1/102 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8D55BK GO:0007472 1/102 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8D55BK GO:0005856 1/102 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8D55BK GO:0031532 1/102 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8D55BK GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8D55BK GO:0007391 1/102 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8D55BK GO:0007049 1/102 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8D55BK GO:0004672 1/102 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8D55BK GO:0007155 1/102 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8D55BK GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D55BK GO:0003676 1/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D55BK GO:0051301 1/102 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8PVRDD GO:0004526 24/98 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8PVRDD GO:0001682 21/98 tRNA 5'-leader removal biological_process "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] EOG8PVRDD GO:0006396 3/98 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8HDW7V GO:0007155 26/98 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8HDW7V GO:0004222 26/98 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8HDW7V GO:0016020 26/98 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HDW7V GO:0005737 2/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HDW7V GO:0008406 2/98 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8HDW7V GO:0007100 2/98 mitotic centrosome separation biological_process "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] EOG8HDW7V GO:0007052 2/98 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8HDW7V GO:0008233 2/98 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8HDW7V GO:0045842 2/98 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8HDW7V GO:0006338 2/98 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8HDW7V GO:0003676 2/98 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HDW7V GO:0008354 2/98 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8HDW7V GO:0046872 2/98 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HDW7V GO:0051298 2/98 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8HDW7V GO:0007420 2/98 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8HDW7V GO:0007076 2/98 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8HDW7V GO:0008270 2/98 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HDW7V GO:0007444 2/98 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8HDW7V GO:0031252 1/98 cell leading edge cellular_component "The area of a motile cell closest to the direction of movement." [GOC:pg] EOG8D55BM GO:0005634 5/89 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55BM GO:0008286 5/89 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG8D55BM GO:0005159 5/89 insulin-like growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl] EOG8D55BM GO:0005737 5/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D55BM GO:0043231 5/89 intracellular membrane-bounded organelle cellular_component "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] EOG8D55BM GO:0010259 5/89 multicellular organismal aging biological_process "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] EOG8D55BM GO:0048009 5/89 insulin-like growth factor receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] EOG8D55BM GO:0005158 5/89 insulin receptor binding molecular_function "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] EOG8D55BM GO:0007296 5/89 vitellogenesis biological_process "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] EOG8D55BM GO:0048477 4/89 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8D55BM GO:0040008 4/89 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG8D55BM GO:0060250 1/89 germ-line stem-cell niche homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] EOG8D55BM GO:0042594 1/89 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8D55BM GO:0007285 1/89 primary spermatocyte growth biological_process "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] EOG8D55BM GO:0008355 1/89 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8D55BM GO:0007295 1/89 growth of a germarium-derived egg chamber biological_process "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8D55BM GO:0040014 1/89 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8D55BM GO:0000902 1/89 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8D55BM GO:0007568 1/89 aging biological_process "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] EOG8D55BM GO:0045793 1/89 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8D55BM GO:0034059 1/89 response to anoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] EOG8D55BM GO:0048133 1/89 male germ-line stem cell asymmetric division biological_process "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid] EOG8D55BM GO:0046620 1/89 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8D55BM GO:0030307 1/89 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8D55BM GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D55BM GO:0042169 1/89 SH2 domain binding molecular_function "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] EOG8D55BM GO:0008340 1/89 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8D55BM GO:0046622 1/89 positive regulation of organ growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8D55BM GO:0008361 1/89 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG8D55BM GO:0008152 1/89 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8D55BM GO:0005829 1/89 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8D55BM GO:0050778 1/89 positive regulation of immune response biological_process "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] EOG8D55BM GO:0043548 1/89 phosphatidylinositol 3-kinase binding molecular_function "Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] EOG8D55BM GO:0035159 1/89 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG8D55BM GO:0040018 1/89 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8Z91CT GO:0043565 37/124 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z91CT GO:0003700 37/124 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z91CT GO:0005634 30/124 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z91CT GO:0032504 1/124 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8Z91CT GO:0005615 1/124 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z91CT GO:0030154 1/124 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8Z91CT GO:0007399 1/124 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8Z91CT GO:0006351 1/124 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG80P6NX GO:0008168 1/5 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG80P6NF GO:0016021 97/327 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6NF GO:0004995 41/327 tachykinin receptor activity molecular_function "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] EOG80P6NF GO:0005886 40/327 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6NF GO:0004983 35/327 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG80P6NF GO:0006935 33/327 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG80P6NF GO:0004950 33/327 chemokine receptor activity molecular_function "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] EOG80P6NF GO:0004930 13/327 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG80P6NF GO:0050254 8/327 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG80P6NF GO:0007186 3/327 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG80P6NF GO:0008188 3/327 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG80P6NF GO:0007218 3/327 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG80P6NF GO:0007217 2/327 tachykinin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] EOG80P6NF GO:0005887 2/327 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6NF GO:0050911 1/327 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG80P6NF GO:0050805 1/327 negative regulation of synaptic transmission biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] EOG80P6NF GO:0042048 1/327 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG80P6NF GO:0007166 1/327 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG80P6NF GO:0004715 1/327 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG80P6NF GO:0001653 1/327 peptide receptor activity molecular_function "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] EOG80P6NF GO:0002121 1/327 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG879HP9 GO:0004035 127/508 alkaline phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] EOG879HP9 GO:0016791 75/508 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG879HP9 GO:0035094 1/508 response to nicotine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] EOG879HP9 GO:0003824 1/508 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG879HP9 GO:0016021 1/508 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HP9 GO:0005576 1/508 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG879HP9 GO:0005615 1/508 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG879HP9 GO:0031225 1/508 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG879HP9 GO:0046872 1/508 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG879HP9 GO:0007399 1/508 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG879HP9 GO:0032504 1/508 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG879HP9 GO:0042045 1/508 epithelial fluid transport biological_process "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] EOG879HP9 GO:0005886 1/508 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6ND GO:0016021 230/726 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6ND GO:0022891 177/726 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0022857 38/726 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0008643 18/726 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG80P6ND GO:0005886 18/726 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6ND GO:0015771 15/726 trehalose transport biological_process "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] EOG80P6ND GO:0015574 15/726 trehalose transmembrane transporter activity molecular_function "Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] EOG80P6ND GO:0032440 8/726 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG80P6ND GO:0016020 2/726 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80P6ND GO:0046427 1/726 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG86MF06 GO:0016757 26/93 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG86MF06 GO:0006488 1/93 dolichol-linked oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309] EOG86MF06 GO:0006486 1/93 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG86MF06 GO:0000009 1/93 alpha-1,6-mannosyltransferase activity molecular_function "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248] EOG86MF06 GO:0005789 1/93 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG86MF06 GO:0052917 1/93 dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.260, RHEA:29538] EOG86MF06 GO:0016021 1/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86MF06 GO:0005783 1/93 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG86MF06 GO:0097502 1/93 mannosylation biological_process "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm] EOG8HDW7F GO:0030983 1/5 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8HDW7F GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HDW7F GO:0006298 1/5 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8HDW7G GO:0008061 12/13 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8HDW7G GO:0005576 12/13 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HDW7G GO:0006030 12/13 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG86MF08 GO:0008270 34/105 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG86MF08 GO:0003676 30/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86MF08 GO:0016874 3/105 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG86MF08 GO:0007095 1/105 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG86MF08 GO:0005652 1/105 nuclear lamina cellular_component "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] EOG86MF08 GO:0003677 1/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86MF08 GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86MF08 GO:0005700 1/105 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG86MF08 GO:0045089 1/105 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG86MF08 GO:0035012 1/105 polytene chromosome, telomeric region cellular_component "The terminal region of a polytene chromosome." [GOC:bf] EOG86MF08 GO:0022008 1/105 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG86MF08 GO:0005634 1/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86MF08 GO:0046426 1/105 negative regulation of JAK-STAT cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG86MF08 GO:0007446 1/105 imaginal disc growth biological_process "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] EOG86MF08 GO:0046425 1/105 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG86MF08 GO:0030097 1/105 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG86MF08 GO:0050829 1/105 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG86MF08 GO:0030261 1/105 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG86MF08 GO:0048749 1/105 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG86MF08 GO:0051276 1/105 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG86MF08 GO:0005654 1/105 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG86MF08 GO:0042176 1/105 regulation of protein catabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] EOG8WSZR6 GO:0004055 20/77 argininosuccinate synthase activity molecular_function "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] EOG8WSZR6 GO:0005524 20/77 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WSZR6 GO:0006526 20/77 arginine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732] EOG8WSZR6 GO:0000050 3/77 urea cycle biological_process "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732] EOG87DCVW GO:0016021 3/24 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCVW GO:0007156 3/24 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG87DCVW GO:0005886 3/24 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87DCVW GO:0005509 3/24 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8H74SV GO:0042384 1/126 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8H74SR GO:0035556 25/94 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8H74SR GO:0007616 1/94 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8H74SR GO:0046426 1/94 negative regulation of JAK-STAT cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8H74SR GO:0043697 1/94 cell dedifferentiation biological_process "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] EOG8H74SR GO:0007482 1/94 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8H74SR GO:0048072 1/94 compound eye pigmentation biological_process "Establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG8H74SR GO:0046425 1/94 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG8H74SR GO:0008586 1/94 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8H74SR GO:0005942 1/94 phosphatidylinositol 3-kinase complex cellular_component "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] EOG8H74SR GO:0045873 1/94 negative regulation of sevenless signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] EOG8H74SR GO:0007298 1/94 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8H74SR GO:0030718 1/94 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8H74SR GO:0048802 1/94 notum morphogenesis biological_process "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] EOG8H74SR GO:0035014 1/94 phosphatidylinositol 3-kinase regulator activity molecular_function "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] EOG8H74SR GO:0045677 1/94 negative regulation of R7 cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8H74SR GO:0042059 1/94 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8D55DT GO:0030246 3/5 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG866Z2P GO:0008270 25/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG866Z2P GO:0016810 22/86 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] EOG866Z2P GO:0004132 2/86 dCMP deaminase activity molecular_function "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] EOG866Z2P GO:0016787 1/86 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG866Z2P GO:0009165 1/86 nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG818F46 GO:0008270 1/173 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG818F46 GO:0003682 1/173 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG818F46 GO:0003676 1/173 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HB109 GO:0005634 3/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HB109 GO:0051028 3/90 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8HB109 GO:0004386 1/90 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8HB109 GO:0005524 1/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HB109 GO:0016887 1/90 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8HB109 GO:0005875 1/90 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8HB109 GO:0004519 1/90 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG818F40 GO:0006030 2/4 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG818F40 GO:0008061 2/4 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG818F40 GO:0005576 2/4 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG847J9W GO:0043565 5/19 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG847J9W GO:0005634 5/19 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PG8FK GO:0035556 2/12 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8PG8FK GO:0009190 2/12 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8PG8FK GO:0016849 2/12 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8FJBQJ GO:0004064 2/99 arylesterase activity molecular_function "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] EOG8FJBQJ GO:0016021 1/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FJBQJ GO:1901739 1/99 regulation of myoblast fusion biological_process "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] EOG8FJBPK GO:0016459 33/148 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8FJBPK GO:0003774 33/148 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8FJBPK GO:0005524 30/148 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FJBPK GO:0032440 2/148 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8FJBPK GO:0060361 1/148 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG8FJBPK GO:0045214 1/148 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8FJBPK GO:0031672 1/148 A band cellular_component "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] EOG8FJBPK GO:0030017 1/148 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8FJBPK GO:0007527 1/148 adult somatic muscle development biological_process "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8FJBPK GO:0042803 1/148 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8FJBPK GO:0007427 1/148 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FJBPK GO:0042623 1/148 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8FJBPK GO:0050821 1/148 protein stabilization biological_process "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] EOG8FJBPK GO:0006936 1/148 muscle contraction biological_process "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] EOG8FJBPK GO:0040011 1/148 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8FJBPK GO:0007517 1/148 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8FJBPK GO:0005863 1/148 striated muscle myosin thick filament cellular_component "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] EOG8FJBPK GO:0005859 1/148 muscle myosin complex cellular_component "A filament of myosin found in a muscle cell of any type." [GOC:mah] EOG8FJBPK GO:0007298 1/148 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FJBPK GO:0006941 1/148 striated muscle contraction biological_process "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] EOG8FJBPK GO:0006200 1/148 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8FJBPK GO:0042692 1/148 muscle cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] EOG8FJBPK GO:0030898 1/148 actin-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] EOG8FJBPK GO:0005703 1/148 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG8FJBPK GO:0008307 1/148 structural constituent of muscle molecular_function "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] EOG8FJBPK GO:0030241 1/148 skeletal muscle myosin thick filament assembly biological_process "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] EOG8FJBPK GO:0031033 1/148 myosin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] EOG8FJBPK GO:0030239 1/148 myofibril assembly biological_process "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] EOG8FJBPM GO:0005622 25/102 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8FJBPM GO:0007165 24/102 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8FJBPM GO:0016021 24/102 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FJBPM GO:0007275 23/102 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FJBPM GO:0004872 23/102 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8FJBPM GO:0016199 1/102 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8FJBPM GO:0017154 1/102 semaphorin receptor activity molecular_function "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958] EOG8FJBPM GO:0071889 1/102 14-3-3 protein binding molecular_function "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237] EOG8FJBPM GO:0008201 1/102 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8FJBPM GO:0007411 1/102 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FJBPM GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FJBPM GO:2000305 1/102 semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance biological_process "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol] EOG8FJBPM GO:0008045 1/102 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8HB10R GO:0007155 28/106 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8HB10R GO:0005198 28/106 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8HB10R GO:0015629 28/106 actin cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] EOG8HB10R GO:0003779 1/106 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG88973W GO:0003777 1/6 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG88973W GO:0005871 1/6 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG88973W GO:0007018 1/6 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8B8MX0 GO:0003899 22/57 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8B8MX0 GO:0003677 22/57 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B8MX0 GO:0006351 21/57 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8B8MX0 GO:0006366 1/57 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8B8MX0 GO:0005736 1/57 DNA-directed RNA polymerase I complex cellular_component "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0006383 1/57 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8B8MX0 GO:0005666 1/57 DNA-directed RNA polymerase III complex cellular_component "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0005665 1/57 DNA-directed RNA polymerase II, core complex cellular_component "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0006360 1/57 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8KM1GS GO:0005524 24/131 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1GS GO:0004714 22/131 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8KM1GS GO:0016021 21/131 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KM1GS GO:0007169 21/131 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8KM1GS GO:0004713 3/131 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8KM1GS GO:0005886 2/131 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KM1GS GO:0007601 2/131 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8KM1GS GO:0007465 1/131 R7 cell fate commitment biological_process "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG8KM1GS GO:0005887 1/131 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KM1GS GO:0045678 1/131 positive regulation of R7 cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8KM1GS GO:0005515 1/131 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KM1GS GO:0045464 1/131 R8 cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] EOG8KM1GS GO:0006468 1/131 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8KM1GS GO:0045466 1/131 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG8KM1GS GO:0042067 1/131 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG8KM1GS GO:0018108 1/131 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8KM1GS GO:0008293 1/131 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8KM1GS GO:0046534 1/131 positive regulation of photoreceptor cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] EOG8KM1GS GO:0008595 1/131 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8KM1GS GO:0045467 1/131 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8WSZRB GO:0001104 1/93 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8WSZRB GO:0016592 1/93 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG86MF0N GO:0005525 1/12 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG86MF0N GO:0006614 1/12 SRP-dependent cotranslational protein targeting to membrane biological_process "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] EOG86MF0N GO:0017111 1/12 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8WSZRD GO:0008173 1/5 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG8WSZRD GO:0005737 1/5 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRD GO:0006364 1/5 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG86MF0H GO:0016021 42/109 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86MF0H GO:0055085 40/109 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG86MF0H GO:0008643 2/109 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG86MF0H GO:0005789 1/109 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG86MF0H GO:0005797 1/109 Golgi medial cisterna cellular_component "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] EOG86MF0H GO:0015780 1/109 nucleotide-sugar transport biological_process "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] EOG86MF0H GO:0005338 1/109 nucleotide-sugar transmembrane transporter activity molecular_function "Enables the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] EOG86MF0H GO:0005783 1/109 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG86MF0H GO:0015788 1/109 UDP-N-acetylglucosamine transport biological_process "The directed movement of UDP-N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] EOG86MF0H GO:0005462 1/109 UDP-N-acetylglucosamine transmembrane transporter activity molecular_function "Enables the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG86MF0H GO:0015790 1/109 UDP-xylose transport biological_process "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] EOG86MF0H GO:0036084 1/109 GDP-fucose import into endoplasmic reticulum lumen biological_process "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] EOG86MF0H GO:0036066 1/109 protein O-linked fucosylation biological_process "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734] EOG86MF0H GO:0005464 1/109 UDP-xylose transmembrane transporter activity molecular_function "Enables the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] EOG86MF0H GO:0005457 1/109 GDP-fucose transmembrane transporter activity molecular_function "Enables the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG86MF0H GO:0015783 1/109 GDP-fucose transport biological_process "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] EOG86MF0H GO:0005794 1/109 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG86MF0H GO:0015012 1/109 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG8QC3M0 GO:0003676 1/127 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S7N7H GO:0004450 1/2 isocitrate dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] EOG8S7N7H GO:0006099 1/2 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8WSZRZ GO:0005737 1/8 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRZ GO:0009001 1/8 serine O-acetyltransferase activity molecular_function "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24563] EOG8WSZRZ GO:0006535 1/8 cysteine biosynthetic process from serine biological_process "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] EOG8PVRD2 GO:0042026 1/10 protein refolding biological_process "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] EOG8PVRD2 GO:0005737 1/10 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PVRD2 GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DRCX6 GO:0009186 3/7 deoxyribonucleoside diphosphate metabolic process biological_process "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG8DRCX6 GO:0055114 3/7 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8WSZRR GO:0016779 3/118 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8WSZRR GO:0043631 2/118 RNA polyadenylation biological_process "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl] EOG8WSZRR GO:0005737 2/118 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRR GO:0046872 2/118 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WSZRR GO:0005515 2/118 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WSZRR GO:0004652 2/118 polynucleotide adenylyltransferase activity molecular_function "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] EOG8WSZRR GO:0005524 2/118 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WSZRR GO:0003723 2/118 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8WSZRR GO:0007052 1/118 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8WSZRR GO:0007343 1/118 egg activation biological_process "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] EOG8WSZRR GO:0043005 1/118 neuron projection cellular_component "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] EOG8WSZRR GO:0035046 1/118 pronuclear migration biological_process "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363] EOG8WSZRR GO:0006378 1/118 mRNA polyadenylation biological_process "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] EOG8WSZRR GO:0002805 1/118 regulation of antimicrobial peptide biosynthetic process biological_process "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] EOG8WSZRR GO:0003887 1/118 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8WSZRR GO:0006397 1/118 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8WSZRR GO:0035044 1/118 sperm aster formation biological_process "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] EOG8WSZRR GO:0007616 1/118 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8WSZRR GO:0007344 1/118 pronuclear fusion biological_process "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] EOG8WSZRR GO:0008298 1/118 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8WSZRR GO:0007056 1/118 spindle assembly involved in female meiosis biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] EOG8WSZRR GO:0048477 1/118 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8WSZRR GO:0001556 1/118 oocyte maturation biological_process "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] EOG8WSZRR GO:0005654 1/118 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8WSZRS GO:0004197 68/247 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WSZRS GO:0006915 68/247 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8WSZRS GO:0010623 2/247 developmental programmed cell death biological_process "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] EOG8WSZRS GO:0016322 2/247 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8WSZRS GO:0045476 2/247 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8WSZRS GO:0005737 2/247 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRS GO:0012501 2/247 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8WSZRS GO:0005515 2/247 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WSZRS GO:0046672 1/247 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WSZRS GO:0009267 1/247 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8WSZRS GO:0035103 1/247 sterol regulatory element binding protein cleavage biological_process "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525] EOG8WSZRS GO:0010165 1/247 response to X-ray biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] EOG8WSZRS GO:0007275 1/247 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8WSZRS GO:0030036 1/247 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8WSZRS GO:0048515 1/247 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8WSZRS GO:0007300 1/247 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8WSZRS GO:0048477 1/247 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8WSZRS GO:0097194 1/247 execution phase of apoptosis biological_process "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] EOG8WSZRS GO:0007015 1/247 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8WSZRS GO:0035071 1/247 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8WSZRS GO:0046668 1/247 regulation of retinal cell programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] EOG8WSZRS GO:0016239 1/247 positive regulation of macroautophagy biological_process "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] EOG8WSZRS GO:0010508 1/247 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8WSZRS GO:0035070 1/247 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8WSZRS GO:1900074 1/247 negative regulation of neuromuscular synaptic transmission biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG8WSZRS GO:0007303 1/247 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8WSZRS GO:0097200 1/247 cysteine-type endopeptidase activity involved in execution phase of apoptosis molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase] EOG8WSZRS GO:0048102 1/247 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8WSZRT GO:0006412 1/14 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WSZRT GO:0005840 1/14 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8WSZRT GO:0003735 1/14 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG866Z30 GO:0034587 1/86 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG866Z30 GO:0046331 1/86 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG866Z30 GO:0005739 1/86 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG844P2S GO:0000502 1/50 proteasome complex cellular_component "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] EOG80ZTD6 GO:0000166 33/98 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG80ZTD6 GO:0003676 31/98 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80ZTD6 GO:0005829 2/98 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG80ZTD6 GO:0006413 2/98 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG80ZTD6 GO:0003729 2/98 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG80ZTD6 GO:0003743 2/98 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG80ZTD6 GO:0005875 1/98 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NKFB8 GO:0004089 104/367 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8NKFB8 GO:0006730 100/367 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8NKFB8 GO:0008270 99/367 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NKFB8 GO:0031233 1/367 intrinsic component of external side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] EOG8DRCV0 GO:0016787 2/6 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8DRCV0 GO:0006284 2/6 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8DRCV0 GO:0051539 1/6 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8DRCV3 GO:0003676 3/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DRCV3 GO:0015074 3/252 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8DRCV3 GO:0003723 2/252 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DRCV3 GO:0008270 2/252 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DRCV3 GO:0003964 2/252 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8DRCV3 GO:0004190 1/252 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG876NDB GO:0005524 142/420 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG876NDB GO:0006950 24/420 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG876NDB GO:0005875 8/420 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG876NDB GO:0009408 7/420 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG876NDB GO:0032440 7/420 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG876NDB GO:0001666 6/420 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG876NDB GO:0035080 6/420 heat shock-mediated polytene chromosome puffing biological_process "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] EOG876NDB GO:0006986 4/420 response to unfolded protein biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] EOG876NDB GO:0005811 3/420 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG876NDB GO:0005515 2/420 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG876NDB GO:0031427 2/420 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG876NDB GO:0016021 1/420 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG876NDB GO:0031209 1/420 SCAR complex cellular_component "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570] EOG876NDB GO:0042594 1/420 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG876NDB GO:0005634 1/420 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG876NDB GO:0006909 1/420 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG876NDB GO:0007528 1/420 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG876NDB GO:0007010 1/420 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG876NDB GO:0030866 1/420 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG876NDB GO:0007520 1/420 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG876NDB GO:0000902 1/420 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG876NDB GO:0048471 1/420 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG876NDB GO:0030031 1/420 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG876NDB GO:0008407 1/420 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG876NDB GO:0008360 1/420 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG876NDB GO:0008340 1/420 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG876NDB GO:0001764 1/420 neuron migration biological_process "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] EOG876NDB GO:0005886 1/420 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG876NDB GO:0007417 1/420 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG876NDB GO:0030036 1/420 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG876NDB GO:0007409 1/420 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG876NDB GO:0022008 1/420 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8NKFB5 GO:0005509 25/70 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NKFB5 GO:0016787 2/70 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8NKFB5 GO:0004198 1/70 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8NKFB5 GO:0006508 1/70 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8NKFB5 GO:0005737 1/70 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKFB5 GO:0046330 1/70 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8DRCV4 GO:0003743 18/79 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8DRCV4 GO:0006413 2/79 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8DRCV4 GO:0032790 1/79 ribosome disassembly biological_process "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] EOG8DRCV4 GO:0006446 1/79 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8DRCV4 GO:0043024 1/79 ribosomal small subunit binding molecular_function "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators] EOG8DRCV4 GO:0008135 1/79 translation factor activity, RNA binding molecular_function "Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] EOG8DRCV4 GO:0005739 1/79 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DRCV4 GO:0001732 1/79 formation of cytoplasmic translation initiation complex biological_process "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] EOG84J53R GO:0000166 1/25 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86T5GX GO:0008137 44/138 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG86T5GX GO:0048038 43/138 quinone binding molecular_function "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] EOG86T5GX GO:0051539 43/138 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG86T5GX GO:0046872 43/138 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86T5GX GO:0032981 1/138 mitochondrial respiratory chain complex I assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] EOG86T5GX GO:0051536 1/138 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG86T5GX GO:0000302 1/138 response to reactive oxygen species biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] EOG86T5GX GO:0008340 1/138 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8GXJ22 GO:0003677 23/90 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GXJ22 GO:0006355 23/90 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GXJ22 GO:0005634 22/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GXJ22 GO:0006351 22/90 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GXJ22 GO:0042752 1/90 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG8GXJ22 GO:0000122 1/90 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GXJ22 GO:0048813 1/90 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8GXJ22 GO:0005739 1/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8GXJ22 GO:0003700 1/90 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8GXJ22 GO:0032922 1/90 circadian regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] EOG8GXJ22 GO:0008137 1/90 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8GXJ28 GO:0043565 24/84 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8GXJ28 GO:0005634 24/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GXJ28 GO:0006351 23/84 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GXJ28 GO:0003700 23/84 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8GXJ28 GO:0045944 1/84 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GXJ28 GO:0048937 1/84 lateral line nerve glial cell development biological_process "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] EOG8GXJ28 GO:0009888 1/84 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8GXJ28 GO:0003690 1/84 double-stranded DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] EOG8GXJ28 GO:0048846 1/84 axon extension involved in axon guidance biological_process "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] EOG8GXJ28 GO:0008301 1/84 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG8GXJ28 GO:0003705 1/84 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8GXJ28 GO:0006366 1/84 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8GXJ28 GO:0048485 1/84 sympathetic nervous system development biological_process "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] EOG8GXJ28 GO:0007422 1/84 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8GXJ28 GO:0007389 1/84 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8GXJ28 GO:0048484 1/84 enteric nervous system development biological_process "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr] EOG8GXJ28 GO:0000122 1/84 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GXJ28 GO:0008134 1/84 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8GXJ28 GO:0005667 1/84 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8GXJ28 GO:0051090 1/84 regulation of sequence-specific DNA binding transcription factor activity biological_process "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] EOG8MSGBZ GO:0005509 37/188 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8MSGBZ GO:0016787 4/188 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8MSGBZ GO:0030170 1/188 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8MSGBZ GO:0008890 1/188 glycine C-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739] EOG8MSGBZ GO:0097206 1/188 nephrocyte filtration biological_process "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] EOG8MSGBZ GO:0005875 1/188 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8MSGBZ GO:0004714 1/188 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8MSGBZ GO:0009058 1/188 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8SFCKZ GO:0006188 30/121 IMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] EOG8SFCKZ GO:0003876 30/121 AMP deaminase activity molecular_function "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] EOG8SFCKZ GO:0005515 1/121 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86T5GG GO:0004252 12/41 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8J3ZWX GO:0005215 1/12 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8J3ZWX GO:0055085 1/12 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8J3ZWX GO:0016020 1/12 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VHNPN GO:0000105 1/3 histidine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] EOG8VHNPN GO:0004424 1/3 imidazoleglycerol-phosphate dehydratase activity molecular_function "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11043] EOG8TQPQ7 GO:0005737 1/4 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TQPQ7 GO:0015976 1/4 carbon utilization biological_process "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] EOG8TQPQ7 GO:0008270 1/4 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TQPQ7 GO:0004089 1/4 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8TQPQ7 GO:0008772 1/4 [isocitrate dehydrogenase (NADP+)] kinase activity molecular_function "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] EOG8TQPQ7 GO:0006006 1/4 glucose metabolic process biological_process "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] EOG8TQPQ7 GO:0016791 1/4 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG86T5G8 GO:0006260 9/99 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG86T5G8 GO:0003677 9/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86T5G8 GO:0005524 4/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86T5G8 GO:0009378 3/99 four-way junction helicase activity molecular_function "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] EOG86T5G8 GO:0006281 3/99 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG86T5G8 GO:0006310 3/99 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG86T5G8 GO:0000166 3/99 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86T5G8 GO:0004386 2/99 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG86T5G8 GO:0017111 2/99 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG86T5G7 GO:0016491 31/106 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG86T5G7 GO:0004303 2/106 estradiol 17-beta-dehydrogenase activity molecular_function "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] EOG89GNZJ GO:0003676 1/9 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89GNZJ GO:0031167 1/9 rRNA methylation biological_process "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] EOG89GNZJ GO:0008168 1/9 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG80P6MR GO:0005524 15/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80P6MR GO:0008026 14/82 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG80P6MR GO:0003676 14/82 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80P6MR GO:0008270 13/82 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80P6MR GO:0006310 9/82 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG80P6MR GO:0008299 1/82 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG80P6MR GO:0045740 1/82 positive regulation of DNA replication biological_process "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] EOG80P6MR GO:0036292 1/82 DNA rewinding biological_process "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634] EOG80P6MR GO:0048477 1/82 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG80P6MR GO:0006302 1/82 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG80P6MR GO:0032508 1/82 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG80P6MR GO:0005634 1/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80P6MR GO:0008094 1/82 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG80P6MR GO:0007307 1/82 eggshell chorion gene amplification biological_process "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] EOG80P6MR GO:0051301 1/82 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG80P6MR GO:0010971 1/82 positive regulation of G2/M transition of mitotic cell cycle biological_process "Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] EOG80P6MR GO:0008284 1/82 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG80P6MR GO:0003678 1/82 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG80P6MR GO:0004452 1/82 isopentenyl-diphosphate delta-isomerase activity molecular_function "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23287] EOG80P6MR GO:0003697 1/82 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG80P6MR GO:0005737 1/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80P6MR GO:0004386 1/82 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG80P6MR GO:0006284 1/82 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG80P6MR GO:0006260 1/82 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG80P6MR GO:0006200 1/82 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG80P6MR GO:0002164 1/82 larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] EOG80P6MR GO:0007095 1/82 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG80P6MR GO:0043140 1/82 ATP-dependent 3'-5' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] EOG8V45NJ GO:0016021 27/114 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V45NJ GO:0005524 27/114 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V45NJ GO:0005388 27/114 calcium-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] EOG8V45NJ GO:0046872 26/114 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8V45NJ GO:0005886 1/114 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8V45NJ GO:0006874 1/114 cellular calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] EOG84N188 GO:0007218 10/22 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG84N188 GO:0007586 2/22 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG84N188 GO:0035177 2/22 larval foraging behavior biological_process "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] EOG84N188 GO:0005576 2/22 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG84N188 GO:0032095 2/22 regulation of response to food biological_process "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] EOG84N188 GO:0035176 2/22 social behavior biological_process "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] EOG84N188 GO:0030536 2/22 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG84N188 GO:0005184 2/22 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG84N188 GO:0007623 1/22 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG84N188 GO:0007186 1/22 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG84N188 GO:0048512 1/22 circadian behavior biological_process "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] EOG84N188 GO:0006950 1/22 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG84N188 GO:0071859 1/22 neuropeptide F receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah] EOG84N188 GO:0008049 1/22 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG84N188 GO:0008345 1/22 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG84N188 GO:0045475 1/22 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG89GNZD GO:0042302 65/232 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG89GNZD GO:0040003 2/232 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG89GNZD GO:0008010 2/232 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG89GNZD GO:0031012 2/232 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8GXJ2J GO:0016772 11/72 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG876ND9 GO:0003676 2/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG876ND9 GO:0015074 2/78 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80ZTDS GO:0007476 1/92 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG80ZTDS GO:0005887 1/92 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG876ND1 GO:0020037 2/18 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG876ND1 GO:0006979 2/18 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG876ND1 GO:0005509 2/18 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG876ND1 GO:0004601 2/18 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG876ND1 GO:0016021 1/18 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DRCVB GO:0007525 1/66 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8DRCVB GO:0000981 1/66 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8DRCVB GO:0005634 1/66 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DRCVB GO:0007498 1/66 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8DRCVB GO:0043425 1/66 bHLH transcription factor binding molecular_function "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] EOG8DRCVB GO:0003677 1/66 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DRCVB GO:0007474 1/66 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8DRCVB GO:0046982 1/66 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8DRCVB GO:0016203 1/66 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8DRCVB GO:0033627 1/66 cell adhesion mediated by integrin biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] EOG8DRCVB GO:0006355 1/66 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8DRCVB GO:0006357 1/66 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8DRCVB GO:0006366 1/66 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG83BQ5X GO:0006836 19/49 neurotransmitter transport biological_process "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] EOG83BQ5X GO:0005326 1/49 neurotransmitter transporter activity molecular_function "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] EOG83BQ5X GO:0048786 1/49 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG83BQ5X GO:0050804 1/49 modulation of synaptic transmission biological_process "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] EOG83BQ5X GO:0051124 1/49 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG83BQ5X GO:0043195 1/49 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG83BQ5X GO:0046928 1/49 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG83BQ5X GO:0016079 1/49 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG83BQ5X GO:0007274 1/49 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG83BQ5X GO:0016020 1/49 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG876ND6 GO:0005262 69/269 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG876ND6 GO:0016021 63/269 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG876ND6 GO:0016020 5/269 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG876ND6 GO:0005515 3/269 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG876ND6 GO:0006816 3/269 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG876ND6 GO:0034703 3/269 cation channel complex cellular_component "An ion channel complex through which cations pass." [GOC:mah] EOG876ND6 GO:0050908 3/269 detection of light stimulus involved in visual perception biological_process "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG876ND6 GO:0016028 3/269 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG876ND6 GO:0009416 3/269 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG876ND6 GO:0046982 2/269 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG876ND6 GO:0071454 2/269 cellular response to anoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah] EOG876ND6 GO:0005886 2/269 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG876ND6 GO:0042802 2/269 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG876ND6 GO:0007605 2/269 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG876ND6 GO:0008086 2/269 light-activated voltage-gated calcium channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport] EOG876ND6 GO:0019722 2/269 calcium-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] EOG876ND6 GO:0015279 2/269 store-operated calcium channel activity molecular_function "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710] EOG876ND6 GO:0005261 2/269 cation channel activity molecular_function "Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG876ND6 GO:0006812 2/269 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG876ND6 GO:0035997 2/269 rhabdomere microvillus membrane cellular_component "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] EOG876ND6 GO:0070588 2/269 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG876ND6 GO:0007603 2/269 phototransduction, visible light biological_process "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG876ND6 GO:0005516 2/269 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG876ND6 GO:0016027 2/269 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG876ND6 GO:0015075 1/269 ion transmembrane transporter activity molecular_function "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] EOG876ND6 GO:0050962 1/269 detection of light stimulus involved in sensory perception biological_process "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] EOG876ND6 GO:0030425 1/269 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG876ND6 GO:0016787 1/269 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG876ND6 GO:0030246 1/269 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG876ND6 GO:0005622 1/269 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG876ND6 GO:0005874 1/269 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG876ND6 GO:0007608 1/269 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG876ND6 GO:0008104 1/269 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG876ND6 GO:0007589 1/269 body fluid secretion biological_process "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] EOG876ND6 GO:0005218 1/269 intracellular ligand-gated calcium channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG876ND6 GO:0030845 1/269 phospholipase C-inhibiting G-protein coupled receptor signaling pathway biological_process "A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098] EOG876ND6 GO:0006811 1/269 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG876ND6 GO:0042803 1/269 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG876ND6 GO:0008355 1/269 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG876ND6 GO:0016740 1/269 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG876ND6 GO:0008377 1/269 light-induced release of internally sequestered calcium ion biological_process "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] EOG876ND6 GO:0000226 1/269 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG89PDGC GO:0008270 4/28 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83BQ5G GO:0030246 9/20 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8FFGHG GO:0005886 1/92 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FFGHG GO:0007561 1/92 imaginal disc eversion biological_process "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] EOG8FFGHG GO:0019898 1/92 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8FFGHG GO:0016849 1/92 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8FFGHG GO:0009190 1/92 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8FFGHG GO:0035556 1/92 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8BZQKC GO:0004867 16/20 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8BZQKC GO:0046331 1/20 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8QZB47 GO:0008270 5/36 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BP3VH GO:0003676 10/61 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BP3VH GO:0008270 10/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PRW6M GO:0030246 3/12 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG87H84B GO:0051297 3/38 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG87H84B GO:0003924 3/38 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG87H84B GO:0000242 3/38 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG87H84B GO:0005874 3/38 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG87H84B GO:0005525 3/38 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG87H84B GO:0051258 3/38 protein polymerization biological_process "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] EOG8TMTHS GO:0016021 8/56 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTHS GO:0005743 8/56 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8TMTHS GO:0005615 2/56 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8TMTHS GO:0004866 2/56 endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] EOG8NW204 GO:0008705 3/10 methionine synthase activity molecular_function "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11175] EOG8NW204 GO:0031419 3/10 cobalamin binding molecular_function "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] EOG8NW204 GO:0008270 3/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NW204 GO:0008898 3/10 S-adenosylmethionine-homocysteine S-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] EOG8NW204 GO:0005622 2/10 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8NW204 GO:0042558 2/10 pteridine-containing compound metabolic process biological_process "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] EOG8FTZG2 GO:0051301 1/86 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8FTZG2 GO:0005783 1/86 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8FTZG2 GO:0005506 1/86 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8FTZG2 GO:0031418 1/86 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8FTZG2 GO:0004656 1/86 procollagen-proline 4-dioxygenase activity molecular_function "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] EOG8FTZG2 GO:0016702 1/86 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] EOG8FTZG0 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FTZG0 GO:0006281 1/6 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8FTZG0 GO:0030870 1/6 Mre11 complex cellular_component "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] EOG8WWV18 GO:0043005 32/118 neuron projection cellular_component "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] EOG8WWV18 GO:0005737 1/118 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WWV18 GO:0005484 1/118 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG8WWV18 GO:0031629 1/118 synaptic vesicle fusion to presynaptic membrane biological_process "Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009] EOG8WWV18 GO:0016192 1/118 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8WWV18 GO:0043195 1/118 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8WWV18 GO:0006893 1/118 Golgi to plasma membrane transport biological_process "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] EOG8WWV18 GO:0048489 1/118 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8WWV18 GO:0048172 1/118 regulation of short-term neuronal synaptic plasticity biological_process "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] EOG8WWV18 GO:0007269 1/118 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8WWV18 GO:0016020 1/118 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8WWV18 GO:0007274 1/118 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8WWV18 GO:0006906 1/118 vesicle fusion biological_process "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] EOG8WWV18 GO:0016082 1/118 synaptic vesicle priming biological_process "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] EOG8WWV18 GO:0005515 1/118 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WWV18 GO:0000149 1/118 SNARE binding molecular_function "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] EOG8WWV18 GO:0030054 1/118 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8WWV18 GO:0016081 1/118 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG8WWV18 GO:0005886 1/118 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WWV18 GO:0031201 1/118 SNARE complex cellular_component "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] EOG8577Q2 GO:0016272 24/76 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8577Q2 GO:0006457 24/76 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8TMTHF GO:0003676 194/895 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TMTHF GO:0003677 58/895 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TMTHF GO:0004519 19/895 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8TMTHF GO:0003964 19/895 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8TMTHF GO:0003723 5/895 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8TMTHF GO:0015074 3/895 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8TMTHF GO:0005524 2/895 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TMTHF GO:0005525 1/895 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8TMTHF GO:0006313 1/895 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8TMTHF GO:0004736 1/895 pyruvate carboxylase activity molecular_function "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847] EOG8TMTHF GO:0006094 1/895 gluconeogenesis biological_process "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] EOG8TMTHF GO:0046872 1/895 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TMTHF GO:0004075 1/895 biotin carboxylase activity molecular_function "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] EOG8TMTHF GO:0004674 1/895 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8TMTHF GO:0004252 1/895 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8TMTHF GO:0008270 1/895 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TMTHF GO:0005634 1/895 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TMTHF GO:0003924 1/895 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8TMTHF GO:0016021 1/895 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTHF GO:0004803 1/895 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8TMTH9 GO:0016788 7/67 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8TMTH9 GO:0003676 7/67 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TMTFW GO:0007426 1/114 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8TMTFW GO:0007165 1/114 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8TMTFW GO:0005515 1/114 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TMTFW GO:0005913 1/114 cell-cell adherens junction cellular_component "An adherens junction which connects a cell to another cell." [GOC:hb] EOG8TMTFW GO:0001751 1/114 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8TMTFW GO:0008293 1/114 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8TMTFW GO:0008586 1/114 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8TMTFW GO:0005737 1/114 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TMTFW GO:0008595 1/114 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8TMTFW GO:0005886 1/114 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TMTFW GO:0007476 1/114 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8TMTFW GO:0007265 1/114 Ras protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] EOG8TMTFW GO:0045177 1/114 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8NW20X GO:0035556 22/96 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8NW20X GO:0016021 22/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW20X GO:0000166 22/96 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NW20X GO:0016849 13/96 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8NW20X GO:0009190 13/96 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8NW20X GO:0004383 9/96 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG8NW20X GO:0006182 1/96 cGMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] EOG8JT2P2 GO:0016192 20/79 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8JT2P2 GO:0016020 20/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8JT2P2 GO:0097352 1/79 autophagosome maturation biological_process "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139] EOG8JT2P2 GO:0000149 1/79 SNARE binding molecular_function "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] EOG8JT2P2 GO:0000046 1/79 autophagosome maturation biological_process "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139] EOG8JT2P2 GO:0005484 1/79 SNAP receptor activity molecular_function "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] EOG8JT2P2 GO:0006887 1/79 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8JT2P2 GO:0031201 1/79 SNARE complex cellular_component "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] EOG8JT2P2 GO:0005886 1/79 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8JT2P2 GO:0006886 1/79 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8JT2P2 GO:0070050 1/79 neuron cellular homeostasis biological_process "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] EOG8JT2P2 GO:0000421 1/79 autophagosome membrane cellular_component "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete] EOG8JT2P2 GO:0016081 1/79 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG8BS00V GO:0003964 1/142 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BS00V GO:0003723 1/142 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BS00S GO:0006281 28/109 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8BS00S GO:0006629 1/109 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8BS00S GO:0007095 1/109 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8X0Q6Z GO:0046872 23/128 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X0Q6Z GO:0003676 6/128 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X0Q6Z GO:0005634 6/128 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X0Q6Z GO:0003723 1/128 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8X0Q6Z GO:0001522 1/128 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG8X0Q6Z GO:0009982 1/128 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG83FKBM GO:0003676 2/20 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZGR GO:0003700 21/56 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FTZGR GO:0043565 21/56 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8FTZGR GO:0005634 21/56 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BS00J GO:0005524 26/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BS00J GO:0003677 25/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BS00J GO:0004386 22/99 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8BS00J GO:0016817 2/99 hydrolase activity, acting on acid anhydrides molecular_function "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] EOG8BS00J GO:0003678 1/99 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8BS00J GO:0000790 1/99 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG8BS00J GO:0003676 1/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BS00J GO:0006338 1/99 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8BS00J GO:0006281 1/99 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8BS00J GO:0006351 1/99 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8BS00J GO:0005700 1/99 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8BS00J GO:0040034 1/99 regulation of development, heterochronic biological_process "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] EOG8BS00J GO:0006200 1/99 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8BS00J GO:0016887 1/99 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8BS00J GO:0006310 1/99 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8BS00J GO:0031011 1/99 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG8BS00J GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BS00J GO:0010468 1/99 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8BS00J GO:0005515 1/99 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8BS00J GO:0045892 1/99 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BS00J GO:0032508 1/99 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8BS00J GO:0000975 1/99 regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] EOG8NW20G GO:0005524 19/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NW20G GO:0004672 18/95 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8NW20G GO:0016772 6/95 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8NW20G GO:0004535 1/95 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG8NW20G GO:0006397 1/95 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8NW20G GO:0046872 1/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NW20G GO:0000932 1/95 cytoplasmic mRNA processing body cellular_component "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] EOG8NW20G GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NW20D GO:0005524 9/61 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NW20D GO:0004713 6/61 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8NW20D GO:0004715 2/61 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8NW20D GO:0004672 1/61 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8X0Q6K GO:0005525 27/110 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8X0Q6K GO:0005524 22/110 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X0Q6K GO:0043023 19/110 ribosomal large subunit binding molecular_function "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators] EOG8X0Q6K GO:0016887 19/110 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8X0Q6K GO:0005737 19/110 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X0Q6K GO:0043022 19/110 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8X0Q6K GO:0006139 3/110 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG8X0Q6K GO:0019205 3/110 nucleobase-containing compound kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] EOG8X0Q6K GO:0007264 1/110 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8X0Q6K GO:0046872 1/110 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X0Q6K GO:0006418 1/110 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG8X0Q6K GO:0004812 1/110 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8X0Q6K GO:0015031 1/110 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG83FKBK GO:0004634 1/3 phosphopyruvate hydratase activity molecular_function "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732] EOG83FKBK GO:0000015 1/3 phosphopyruvate hydratase complex cellular_component "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] EOG83FKBK GO:0006096 1/3 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG83FKBK GO:0000287 1/3 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG89W4WC GO:0005737 24/86 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89W4WC GO:0061024 1/86 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG89W4WC GO:0016020 1/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG89W4WC GO:0007296 1/86 vitellogenesis biological_process "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] EOG89W4WC GO:0030100 1/86 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG84N196 GO:0008188 1/7 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG84N196 GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80KBF0 GO:0003677 8/40 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80KBF0 GO:0003887 8/40 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG80KBF0 GO:0006281 6/40 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG89W4WM GO:0008157 1/112 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8VX4MW GO:0043066 1/89 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8VX4MW GO:1990050 1/89 phosphatidic acid transporter activity molecular_function "Enables the directed movement of phosphatidic acid into, out of or within a cell, or between cells. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293] EOG8VX4MW GO:0015914 1/89 phospholipid transport biological_process "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] EOG8VX4MW GO:0000910 1/89 cytokinesis biological_process "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] EOG8VX4MW GO:0000226 1/89 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8VX4MW GO:0048813 1/89 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8VX4MW GO:0005758 1/89 mitochondrial intermembrane space cellular_component "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] EOG8VX4MW GO:0030061 1/89 mitochondrial crista cellular_component "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732] EOG8VX4MW GO:0070584 1/89 mitochondrion morphogenesis biological_process "The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah] EOG8VX4MW GO:0005739 1/89 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG89W4WT GO:0015628 1/9 protein secretion by the type II secretion system biological_process "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] EOG89W4WT GO:0008565 1/9 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG89W4WT GO:0015627 1/9 type II protein secretion system complex cellular_component "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] EOG805VDW GO:0016020 82/211 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VDW GO:0005215 82/211 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG805VDW GO:0031427 1/211 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FR35V GO:0016021 33/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FR35V GO:0015299 32/136 solute:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] EOG8FR35V GO:0000166 1/136 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8FR35V GO:0035725 1/136 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8FR35V GO:0015385 1/136 sodium:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] EOG8FR35V GO:0003676 1/136 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FR35V GO:0003096 1/136 renal sodium ion transport biological_process "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] EOG8FR35V GO:0005903 1/136 brush border cellular_component "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] EOG8QRKKK GO:0016747 2/7 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG84F8T2 GO:0006809 1/5 nitric oxide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] EOG84F8T2 GO:0004517 1/5 nitric-oxide synthase activity molecular_function "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] EOG8FR35F GO:0035220 1/86 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8FR35F GO:0045214 1/86 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8FR35F GO:0048734 1/86 proboscis morphogenesis biological_process "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc] EOG8FR35F GO:0007527 1/86 adult somatic muscle development biological_process "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8FR35F GO:0004725 1/86 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8FR35F GO:0048802 1/86 notum morphogenesis biological_process "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] EOG8FR35D GO:0008270 17/109 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FR35D GO:0016491 4/109 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8FR35D GO:0004725 2/109 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8FR35D GO:0043914 1/109 NADPH:sulfur oxidoreductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625] EOG8FR35D GO:0006098 1/109 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG8FR35D GO:0019417 1/109 sulfur oxidation biological_process "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] EOG8FR35D GO:0016709 1/109 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG8FR35D GO:0071949 1/109 FAD binding molecular_function "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] EOG8FR35D GO:0003779 1/109 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8FR35D GO:0043195 1/109 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8FR35D GO:0005829 1/109 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8FR35D GO:0007411 1/109 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FR35D GO:0016322 1/109 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8FR35D GO:0070995 1/109 NADPH oxidation biological_process "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah] EOG8FR35D GO:0055114 1/109 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8FR35D GO:0005886 1/109 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FR35D GO:0004345 1/109 glucose-6-phosphate dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] EOG8FR35D GO:0030047 1/109 actin modification biological_process "Covalent modification of an actin molecule." [GOC:mah] EOG8FR35D GO:0048813 1/109 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8FR35D GO:0050661 1/109 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG8FR35D GO:0045214 1/109 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8FR35D GO:0030042 1/109 actin filament depolymerization biological_process "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] EOG8QVFW1 GO:0016021 2/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QVFW1 GO:0004930 2/3 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8QVFW1 GO:0007218 1/3 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8D296V GO:0005634 6/48 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JWXW3 GO:0005576 1/22 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JWXW3 GO:0042742 1/22 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8JWXW3 GO:0045087 1/22 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8JWXW3 GO:0042832 1/22 defense response to protozoan biological_process "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] EOG8JWXW3 GO:0050777 1/22 negative regulation of immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] EOG81G5MK GO:0046872 2/8 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FR35K GO:0005576 6/150 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FR35K GO:0055114 1/150 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8FR35K GO:0016117 1/150 carotenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] EOG8NGK4V GO:0003723 1/7 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NGK4V GO:0003964 1/7 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VT8BC GO:0003824 1/101 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8VT8BC GO:0035075 1/101 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG8VT8BC GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VT8BC GO:0008344 1/101 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8VT8BC GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VT8BC GO:0006351 1/101 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8VT8BC GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8VT8BC GO:0007275 1/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8VT8BC GO:0004402 1/101 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8VT8BC GO:0071254 1/101 cytoplasmic U snRNP body cellular_component "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] EOG8VT8BC GO:0007591 1/101 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG8VT8BC GO:0006355 1/101 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8VT8BC GO:0007629 1/101 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8JMB48 GO:0044237 25/89 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8JMB48 GO:0050662 25/89 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8JMB48 GO:0003824 22/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8JMB48 GO:0048040 2/89 UDP-glucuronate decarboxylase activity molecular_function "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23919] EOG8JMB48 GO:0008460 1/89 dTDP-glucose 4,6-dehydratase activity molecular_function "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224] EOG8JMB48 GO:0003676 1/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JMB48 GO:0000166 1/89 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8M948P GO:0006357 1/4 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8M948P GO:0051726 1/4 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG84QWDX GO:0035317 1/95 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG84QWDX GO:0005938 1/95 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG84QWDX GO:0035017 1/95 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG84QWDX GO:0048800 1/95 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG84QWDX GO:0009913 1/95 epidermal cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] EOG8VT8BH GO:0007126 16/158 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8VT8BH GO:0005737 16/158 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VT8BH GO:0005634 16/158 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VT8BH GO:0031047 16/158 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8VT8BH GO:0007275 15/158 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8VT8BH GO:0006351 14/158 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8VT8BH GO:0030718 14/158 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8VT8BH GO:0048471 14/158 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8VT8BH GO:0043186 14/158 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8VT8BH GO:0045892 14/158 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8VT8BH GO:0048477 14/158 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8VT8BH GO:0034587 14/158 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG8VT8BH GO:0044212 14/158 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG8VT8BH GO:0007283 14/158 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8VT8BH GO:0060964 14/158 regulation of gene silencing by miRNA biological_process "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb] EOG8VT8BH GO:0003677 2/158 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VT8BH GO:0030154 2/158 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8VT8BH GO:0019094 1/158 pole plasm mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8VT8BH GO:0031023 1/158 microtubule organizing center organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] EOG8VT8BH GO:0048600 1/158 oocyte fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators] EOG8VT8BH GO:0007317 1/158 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8VT8BH GO:0007312 1/158 oocyte nucleus migration involved in oocyte dorsal/ventral axis specification biological_process "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] EOG8VT8BH GO:0007010 1/158 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8VT8BH GO:0010586 1/158 miRNA metabolic process biological_process "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] EOG8VT8BH GO:0008298 1/158 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8VT8BH GO:0003723 1/158 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VT8BH GO:0010529 1/158 negative regulation of transposition biological_process "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] EOG8VT8BH GO:0009950 1/158 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8VT8BH GO:0003964 1/158 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VT8BH GO:0008104 1/158 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8VT8BH GO:0016325 1/158 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8VT8BH GO:0007314 1/158 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8VT8BH GO:0043565 1/158 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8VT8BT GO:0003995 32/99 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8VT8BT GO:0050660 31/99 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8VT8BT GO:0043958 2/99 acryloyl-CoA reductase activity molecular_function "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] EOG8VT8BT GO:0005811 1/99 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8VT8BT GO:0005739 1/99 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8VT8BT GO:0005759 1/99 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8VT8BT GO:0005875 1/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8VT8BT GO:0006635 1/99 fatty acid beta-oxidation biological_process "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] EOG8VT8BT GO:0005524 1/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80S304 GO:0003677 2/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VT8BQ GO:0050662 23/81 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8VT8BQ GO:0044237 23/81 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8VT8BQ GO:0003824 22/81 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8VT8BQ GO:0003978 1/81 UDP-glucose 4-epimerase activity molecular_function "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] EOG8D81M4 GO:0008270 14/51 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81M4 GO:0003779 1/51 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8D81M6 GO:0016021 1/64 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D81MM GO:0016491 49/162 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D81MM GO:0004316 1/162 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8D81MM GO:0005811 1/162 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG87Q0QX GO:0007264 1/2 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG87Q0QX GO:0016020 1/2 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG87Q0QX GO:0005525 1/2 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG87Q0QX GO:0006184 1/2 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8J6V4T GO:0003676 23/90 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J6V4T GO:0071011 1/90 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8J6V4T GO:0071013 1/90 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8J6V4T GO:0000398 1/90 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8VT8B7 GO:0016021 27/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VT8B7 GO:0008270 4/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VT8B7 GO:0035045 1/94 sperm plasma membrane disassembly biological_process "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] EOG8VT8B7 GO:0001669 1/94 acrosomal vesicle cellular_component "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] EOG8VT8B7 GO:0035042 1/94 fertilization, exchange of chromosomal proteins biological_process "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001] EOG8VT8B7 GO:0035041 1/94 sperm chromatin decondensation biological_process "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001] EOG8D81MZ GO:0008270 2/13 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81MZ GO:0003960 1/13 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG8D81MZ GO:0016491 1/13 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8C8B7Z GO:0016787 2/8 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C8B7Z GO:0033883 1/8 pyridoxal phosphatase activity molecular_function "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] EOG8WQ3J1 GO:0051301 1/62 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8Q2GZC GO:0003676 1/58 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q2GZC GO:0004523 1/58 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8Q2GZC GO:0007165 1/58 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8VT8B9 GO:0016021 63/217 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VT8B9 GO:0004930 44/217 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8VT8B9 GO:0001607 19/217 neuromedin U receptor activity molecular_function "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] EOG8VT8B9 GO:0036401 3/217 pyrokinin receptor activity molecular_function "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060] EOG8VT8B9 GO:0050254 3/217 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8VT8B9 GO:0007218 3/217 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8VT8B9 GO:0005887 3/217 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VT8B9 GO:0007186 3/217 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8VT8B9 GO:0008188 3/217 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8VT8B9 GO:0001653 1/217 peptide receptor activity molecular_function "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] EOG8QVFWC GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QVFWC GO:0005024 1/7 transforming growth factor beta-activated receptor activity molecular_function "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] EOG8JWXWH GO:0005743 1/4 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8JWXWH GO:0070469 1/4 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8JWXWH GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JWXWH GO:0008137 1/4 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8JWXWH GO:0006120 1/4 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG8D2962 GO:0003964 185/1227 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8D2962 GO:0003723 151/1227 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D2962 GO:0004519 49/1227 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8D2962 GO:0006355 11/1227 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D2962 GO:0003676 2/1227 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D2962 GO:0003677 2/1227 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8D2962 GO:0008270 1/1227 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D2962 GO:0046872 1/1227 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D2962 GO:0008234 1/1227 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8D2962 GO:0050660 1/1227 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8D2962 GO:0016021 1/1227 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D2962 GO:0008033 1/1227 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8D2962 GO:0005634 1/1227 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D2962 GO:0022857 1/1227 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8NKF8F GO:0004842 31/105 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8NKF8F GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKF8F GO:0016874 1/105 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8NKF8F GO:0005634 1/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NKF8F GO:0042787 1/105 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8B8MWF GO:0045454 55/184 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8B8MWF GO:0006662 55/184 glycerol ether metabolic process biological_process "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732] EOG8B8MWF GO:0015035 55/184 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8B8MWF GO:0006974 2/184 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8B8MWF GO:0016853 1/184 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8J13NZ GO:0005524 28/93 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8J13NZ GO:0003676 28/93 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J13NZ GO:0008026 26/93 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8J13NZ GO:0004386 3/93 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8J13NZ GO:0008152 1/93 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8J13NZ GO:0005634 1/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J13NZ GO:0000381 1/93 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG81VNK5 GO:0003824 1/3 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81VNK5 GO:0044237 1/3 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG81VNK5 GO:0050662 1/3 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8NKF8J GO:0008270 7/45 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NKF8J GO:0004181 7/45 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG88972N GO:0003824 36/99 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG88972N GO:0016853 1/99 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG88972N GO:0004165 1/99 dodecenoyl-CoA delta-isomerase activity molecular_function "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] EOG88972N GO:0071456 1/99 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG88972N GO:0006909 1/99 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG81VNK1 GO:0001539 1/52 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG81VNK1 GO:0003774 1/52 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG81VNK1 GO:0009288 1/52 bacterial-type flagellum cellular_component "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] EOG8RR8X6 GO:0007018 9/40 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8RR8X6 GO:0003777 9/40 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG88972Q GO:0016021 3/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RR8X5 GO:0016021 27/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RR8X5 GO:0046872 26/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RR8X5 GO:0005524 26/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RR8X5 GO:0005388 24/95 calcium-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] EOG8RR8X5 GO:0019829 3/95 cation-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] EOG8RR8X5 GO:0033017 3/95 sarcoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] EOG8RR8X5 GO:0005783 2/95 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8RR8X5 GO:0016529 2/95 sarcoplasmic reticulum cellular_component "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] EOG8RR8X5 GO:0005811 1/95 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8RR8X5 GO:1901896 1/95 positive regulation of calcium-transporting ATPase activity biological_process "Any process that activates or increases the frequency, rate or extent of calcium-transporting ATPase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] EOG8RR8X5 GO:0048863 1/95 stem cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] EOG8RR8X5 GO:0007629 1/95 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8RR8X5 GO:0036335 1/95 intestinal stem cell homeostasis biological_process "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] EOG8RR8X5 GO:0060047 1/95 heart contraction biological_process "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] EOG8RR8X5 GO:0070588 1/95 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8RR8X5 GO:0030322 1/95 stabilization of membrane potential biological_process "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] EOG8RR8X5 GO:0007274 1/95 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8RR8X5 GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RR8X5 GO:0005635 1/95 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG8RR8X5 GO:0051282 1/95 regulation of sequestering of calcium ion biological_process "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] EOG8RR8X5 GO:0006874 1/95 cellular calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] EOG8NKF8R GO:0005759 1/13 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8NKF8R GO:0005743 1/13 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8NKF8R GO:0005525 1/13 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8NKF8R GO:0043022 1/13 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8NKF8R GO:0003924 1/13 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8NKF8R GO:0006412 1/13 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8NKF8R GO:0045727 1/13 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG81NX41 GO:0016021 3/67 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q9BT GO:0003723 1/2 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8323CW GO:0016620 1/6 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8CC6JD GO:0008270 4/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CC6JD GO:0005634 4/52 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6JD GO:0046872 1/52 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CC6JD GO:0016568 1/52 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG82VBW1 GO:0032012 25/98 regulation of ARF protein signal transduction biological_process "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] EOG82VBW1 GO:0005086 25/98 ARF guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG82VBW1 GO:0005524 1/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82VBW1 GO:0005802 1/98 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG82VBW1 GO:0043087 1/98 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG82VBW1 GO:0005515 1/98 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82VBW1 GO:0005097 1/98 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG82VBW1 GO:0016192 1/98 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG82VBW1 GO:0004672 1/98 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG86MF1H GO:0004871 28/103 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG86MF1H GO:0005634 24/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86MF1H GO:0006355 23/103 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86MF1H GO:0006351 23/103 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86MF1H GO:0003677 23/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86MF1H GO:0003700 2/103 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86MF1H GO:0046982 1/103 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG86MF1H GO:0043565 1/103 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG86MF1H GO:0006366 1/103 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86MF1H GO:0005667 1/103 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG86MF1H GO:0000981 1/103 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG86MF1H GO:0072175 1/103 epithelial tube formation biological_process "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] EOG86MF1H GO:0048813 1/103 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG86MF1H GO:0045944 1/103 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86MF1H GO:0046331 1/103 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG86MF1H GO:0007443 1/103 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG86MF1H GO:0007431 1/103 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG86MF1H GO:0035277 1/103 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG86MF1H GO:0007424 1/103 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG86MF1H GO:0007425 1/103 epithelial cell fate determination, open tracheal system biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] EOG86MF1H GO:0005737 1/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86MF1H GO:0007435 1/103 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8CJXZ5 GO:0005524 23/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CJXZ5 GO:0004713 20/91 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8CJXZ5 GO:0004674 2/91 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8CJXZ5 GO:0004715 2/91 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8CJXZ5 GO:0004672 2/91 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8CJXZ5 GO:0007015 1/91 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8CJXZ5 GO:0045177 1/91 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8CJXZ5 GO:0006468 1/91 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8CJXZ5 GO:0001700 1/91 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8CJXZ5 GO:0045873 1/91 negative regulation of sevenless signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] EOG8CJXZ5 GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8MGVN3 GO:0006898 1/103 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG8MGVN3 GO:0007298 1/103 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8MGVN3 GO:0005875 1/103 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG86MF1T GO:0008270 1/7 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG86MF1T GO:0003712 1/7 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG86MF1T GO:0004402 1/7 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG86MF1T GO:0005634 1/7 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86MF1T GO:0006355 1/7 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CJXZ6 GO:0015937 6/89 coenzyme A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] EOG8CJXZ6 GO:0005524 6/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CJXZ6 GO:0004594 6/89 pantothenate kinase activity molecular_function "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] EOG8CJXZ6 GO:0016301 1/89 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8TXF89 GO:0006353 1/33 DNA-templated transcription, termination biological_process "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] EOG8TXF5N GO:0005248 20/130 voltage-gated sodium channel activity molecular_function "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8TXF5N GO:0001518 20/130 voltage-gated sodium channel complex cellular_component "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] EOG8TXF5N GO:0005216 8/130 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8TXF5N GO:0016021 8/130 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TXF5N GO:0005886 1/130 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TXF5N GO:0035725 1/130 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8TXF5N GO:0006814 1/130 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8TXF5N GO:0007608 1/130 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8TXF5N GO:0008270 1/130 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TXF5N GO:0003723 1/130 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8TXF5N GO:0042048 1/130 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8TXF5N GO:0022843 1/130 voltage-gated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8TXF5N GO:0086010 1/130 membrane depolarization during action potential biological_process "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] EOG8TXF5N GO:0003964 1/130 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8TXF5N GO:0019228 1/130 neuronal action potential biological_process "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] EOG8CJXZ8 GO:0005515 1/80 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CJXZ8 GO:0016021 1/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXZ8 GO:0019005 1/80 SCF ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] EOG8CJXZ8 GO:0031647 1/80 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8CJXZ8 GO:0009952 1/80 anterior/posterior pattern specification biological_process "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8323CN GO:0016114 1/10 terpenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] EOG8323CN GO:0005525 1/10 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8323CN GO:0046429 1/10 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431] EOG82VBWX GO:0005525 3/15 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG82VBWX GO:0000917 2/15 barrier septum assembly biological_process "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle] EOG8S7N61 GO:0016491 24/82 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8S7N61 GO:0045454 1/82 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8S7N61 GO:0043066 1/82 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8S7N61 GO:0051920 1/82 peroxiredoxin activity molecular_function "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] EOG8S7N61 GO:0045824 1/82 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8S7N61 GO:0004601 1/82 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8S7N61 GO:0005829 1/82 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8S7N61 GO:0005634 1/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S7N61 GO:0006979 1/82 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8S7N61 GO:0005739 1/82 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8S7N61 GO:0008340 1/82 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG86MF17 GO:0046872 3/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CJXZR GO:0016021 21/53 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXZR GO:0004930 20/53 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8CJXZR GO:0005887 1/53 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXZR GO:0007218 1/53 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8CJXZR GO:0035236 1/53 proctolin receptor activity molecular_function "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] EOG8CJXZR GO:0008188 1/53 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8CJXZR GO:0007186 1/53 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8MGVNX GO:0008455 37/112 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] EOG8MGVNX GO:0016021 37/112 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MGVNX GO:0009312 37/112 oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] EOG8MGVNX GO:0005795 36/112 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8MGVNX GO:0006487 1/112 protein N-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] EOG8MGVNX GO:0005797 1/112 Golgi medial cisterna cellular_component "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] EOG8MGVNX GO:0008375 1/112 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG82VBWF GO:0005681 1/115 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG82VBWF GO:0000398 1/115 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8RR8XB GO:0005737 1/114 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RR8XB GO:0050839 1/114 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8RR8XB GO:0016081 1/114 synaptic vesicle docking biological_process "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] EOG8RR8XB GO:0016080 1/114 synaptic vesicle targeting biological_process "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] EOG8RR8XB GO:0007163 1/114 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8RR8XB GO:0007269 1/114 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8RR8XB GO:0048749 1/114 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8T1M1F GO:0005795 98/220 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8T1M1F GO:0008378 92/220 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8T1M1F GO:0050512 6/220 lactosylceramide 4-alpha-galactosyltransferase activity molecular_function "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] EOG8T1M1F GO:0009247 1/220 glycolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] EOG8T1M1F GO:0006688 1/220 glycosphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] EOG8T1M1F GO:0035248 1/220 alpha-1,4-N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] EOG8T1M1F GO:0016787 1/220 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8T1M1F GO:0008376 1/220 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG8T1M1F GO:0045747 1/220 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8T1M1F GO:0043066 1/220 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81VNKX GO:0003676 5/17 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80307Z GO:0005576 10/13 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80307Z GO:0008061 10/13 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80307Z GO:0006030 10/13 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80307Z GO:0005201 1/13 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG80307Z GO:0031012 1/13 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8T1M1Q GO:0003824 16/77 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8T1M1Q GO:0004528 4/77 phosphodiesterase I activity molecular_function "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] EOG8T1M1Q GO:0046872 2/77 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8T1M1Q GO:0003676 2/77 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M1Q GO:0035529 1/77 NADH pyrophosphatase activity molecular_function "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750] EOG8T1M1Q GO:0016787 1/77 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8HB112 GO:0016021 34/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HB112 GO:0055085 34/136 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8HB112 GO:0005886 12/136 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HB112 GO:0005215 12/136 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG889726 GO:0005975 1/3 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG889726 GO:0004553 1/3 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG889726 GO:0043169 1/3 cation binding molecular_function "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] EOG818F59 GO:0003950 20/49 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG8TXF5Q GO:0016021 1/33 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TXF5Q GO:0008158 1/33 hedgehog receptor activity molecular_function "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137] EOG8MD0F0 GO:0004725 5/56 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8MD0F0 GO:0050254 3/56 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8NCPSW GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NCPSW GO:0022416 1/95 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8NCPSW GO:0005634 1/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NCPSW GO:0000122 1/95 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NCPSW GO:0017053 1/95 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG8NCPSW GO:0003682 1/95 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8NCPSW GO:0045747 1/95 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8NCPSW GO:0045572 1/95 positive regulation of imaginal disc growth biological_process "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] EOG8NCPSW GO:0030162 1/95 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8NCPSW GO:0042058 1/95 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8NCPSW GO:0070491 1/95 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8NCPSW GO:0042676 1/95 compound eye cone cell fate commitment biological_process "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] EOG8NCPSW GO:0004402 1/95 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8NCPSW GO:0007049 1/95 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8NCPSW GO:0007601 1/95 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8NCPSW GO:0042461 1/95 photoreceptor cell development biological_process "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] EOG8NCPSW GO:0007219 1/95 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8NCPSW GO:0005700 1/95 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8NCPSW GO:0007173 1/95 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8NCPSW GO:0031065 1/95 positive regulation of histone deacetylation biological_process "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] EOG8NCPSW GO:0005525 1/95 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8NCPSW GO:0035220 1/95 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8GXJ3F GO:0003676 3/16 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86DPH7 GO:0016740 2/7 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG86DPH7 GO:0005737 2/7 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86DPH7 GO:0051539 2/7 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG86DPH7 GO:0006400 2/7 tRNA modification biological_process "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] EOG86DPH2 GO:0016021 4/35 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86DPH2 GO:0004930 3/35 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG86DPH2 GO:0004983 1/35 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG86DPH2 GO:0007218 1/35 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG83N9T9 GO:0003743 27/97 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG83N9T9 GO:0016282 26/97 eukaryotic 43S preinitiation complex cellular_component "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] EOG83N9T9 GO:0006446 26/97 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG83N9T9 GO:0001731 26/97 formation of translation preinitiation complex biological_process "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] EOG83N9T9 GO:0005852 26/97 eukaryotic translation initiation factor 3 complex cellular_component "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] EOG83N9T9 GO:0033290 26/97 eukaryotic 48S preinitiation complex cellular_component "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] EOG83N9T9 GO:0006413 1/97 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG83N9T9 GO:0004402 1/97 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG83N9T9 GO:0005875 1/97 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8BVV85 GO:0003723 8/15 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BVV85 GO:0003964 8/15 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BVV85 GO:0004519 1/15 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8BVV85 GO:0006355 1/15 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG89PDDF GO:0016021 7/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89PDDF GO:0005230 6/19 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG89PDDF GO:0005886 5/19 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89PDDF GO:0030054 3/19 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG89PDDF GO:0045202 3/19 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG89PDDF GO:0006811 1/19 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG83BQ4D GO:0008146 43/146 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG83BQ4D GO:0008459 4/146 chondroitin 6-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] EOG83BQ4D GO:0016740 1/146 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8642T3 GO:0003676 3/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NKFCP GO:0042981 1/3 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8NKFCP GO:0005622 1/3 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83BQ4M GO:0005085 6/45 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG83BQ4M GO:0007264 6/45 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG89PDDJ GO:0003735 26/88 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG89PDDJ GO:0006412 26/88 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG89PDDJ GO:0005840 25/88 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG89PDDJ GO:0005762 1/88 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8642T5 GO:0005524 3/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8642T5 GO:0008559 2/14 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG8642T5 GO:0016021 2/14 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8642T5 GO:0042626 1/14 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8F4VRH GO:0008270 24/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F4VRH GO:0003676 1/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z91BR GO:0003700 85/407 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z91BR GO:0005524 85/407 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z91BR GO:0005634 85/407 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z91BR GO:0003677 84/407 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Z91BR GO:0006351 83/407 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8Z91BR GO:0007031 24/407 peroxisome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] EOG8Z91BR GO:0005779 24/407 integral component of peroxisomal membrane cellular_component "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] EOG8Z91BR GO:0043565 2/407 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z91BR GO:0045944 2/407 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Z91BR GO:0048813 2/407 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8Z91BR GO:0048592 2/407 eye morphogenesis biological_process "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] EOG8Z91BR GO:0001709 1/407 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8Z91BR GO:0007469 1/407 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG8Z91BR GO:0000122 1/407 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Z91BR GO:0042675 1/407 compound eye cone cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] EOG8Z91BR GO:0030154 1/407 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8Z91BR GO:0045165 1/407 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG8Z91BR GO:0048749 1/407 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8Z91BR GO:0006366 1/407 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8Z91BR GO:0003705 1/407 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8Z91BR GO:0035162 1/407 embryonic hemopoiesis biological_process "The stages of blood cell formation that take place within the embryo." [GOC:bf] EOG8Z91BR GO:0007486 1/407 imaginal disc-derived female genitalia development biological_process "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG8Z91BR GO:0030097 1/407 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8Z91BR GO:0035170 1/407 lymph gland crystal cell differentiation biological_process "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] EOG8Z91BR GO:0042688 1/407 crystal cell differentiation biological_process "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] EOG8Z91BR GO:0035163 1/407 embryonic hemocyte differentiation biological_process "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] EOG8Z91BR GO:0045893 1/407 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Z91BR GO:0035211 1/407 spermathecum morphogenesis biological_process "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] EOG8Z91BR GO:0016360 1/407 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG8Z91BR GO:0046672 1/407 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8Z91BR GO:0009987 1/407 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8Z91BR GO:0007419 1/407 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8Z91BR GO:0007165 1/407 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8Z91BR GO:0045892 1/407 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Z91BR GO:0035314 1/407 scab formation biological_process "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788] EOG8Z91BR GO:0044212 1/407 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG8Z91BR GO:0048477 1/407 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8Z91BR GO:0007377 1/407 germ-band extension biological_process "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] EOG8Z91BR GO:0035168 1/407 larval lymph gland hemocyte differentiation biological_process "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069] EOG8Z91BR GO:0045467 1/407 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8Z91BR GO:0035165 1/407 embryonic crystal cell differentiation biological_process "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] EOG8Z91BR GO:0007366 1/407 periodic partitioning by pair rule gene biological_process "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8Z91BR GO:0042060 1/407 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8Z91BR GO:0007411 1/407 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8Z91BR GO:0007400 1/407 neuroblast fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] EOG8Z91BR GO:0007540 1/407 sex determination, establishment of X:A ratio biological_process "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete] EOG8Z91BR GO:0007367 1/407 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8642TN GO:0016491 1/7 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8642TN GO:0008670 1/7 2,4-dienoyl-CoA reductase (NADPH) activity molecular_function "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] EOG8H1D8T GO:0005524 1/104 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H1D8T GO:0004713 1/104 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8H1D8T GO:0042384 1/104 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG82RGRV GO:0008026 1/2 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG82RGRV GO:0005524 1/2 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82RGRV GO:0003676 1/2 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82RGRV GO:0009294 1/2 DNA mediated transformation biological_process "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)] EOG82RGRV GO:0006310 1/2 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG866Z2B GO:0006223 2/10 uracil salvage biological_process "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] EOG866Z2B GO:0004845 2/10 uracil phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13020] EOG8TB6SV GO:0006355 3/17 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8TB6SV GO:0005524 3/17 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TB6SV GO:0017111 3/17 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8TB6SV GO:0000156 2/17 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8TB6SV GO:0043565 1/17 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8XD695 GO:0004672 1/2 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8XD695 GO:0005524 1/2 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z91BG GO:0005524 27/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z91BG GO:0005674 27/92 transcription factor TFIIF complex cellular_component "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] EOG8Z91BG GO:0006367 27/92 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8Z91BG GO:0008026 15/92 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8Z91BG GO:0003824 12/92 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8Z91BG GO:0003743 4/92 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8Z91BG GO:0001096 1/92 TFIIF-class transcription factor binding molecular_function "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] EOG8Z91BG GO:0045944 1/92 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Z91BG GO:0032968 1/92 positive regulation of transcription elongation from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] EOG8Z91BG GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Z91BG GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z91BG GO:0060261 1/92 positive regulation of transcription initiation from RNA polymerase II promoter biological_process "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] EOG8PVRGC GO:0005549 63/151 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8PVRGC GO:0005576 2/151 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PVRGC GO:0007606 2/151 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8PVRGC GO:0005550 2/151 pheromone binding molecular_function "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] EOG8PVRGC GO:0006810 1/151 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG81K1T3 GO:0003676 5/31 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81K1T3 GO:0008270 2/31 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1T3 GO:0005634 2/31 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8H1D8K GO:0019217 1/95 regulation of fatty acid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] EOG8H1D8K GO:0019432 1/95 triglyceride biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732] EOG8H1D8K GO:0003755 1/95 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8H1D8K GO:0007474 1/95 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8H1D8K GO:0010565 1/95 regulation of cellular ketone metabolic process biological_process "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] EOG8H1D8K GO:0006357 1/95 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8H1D8K GO:0003713 1/95 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8H1D8K GO:0008195 1/95 phosphatidate phosphatase activity molecular_function "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr] EOG8H1D8K GO:0055088 1/95 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8H1D8K GO:0030514 1/95 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8H1D8K GO:0005737 1/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8H1D8K GO:0035183 1/95 female germline ring canal inner rim cellular_component "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] EOG8H1D8K GO:0016311 1/95 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8H1D8K GO:0005634 1/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8H1D8K GO:0042594 1/95 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8QC3NM GO:0016020 38/153 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QC3NM GO:0016202 2/153 regulation of striated muscle tissue development biological_process "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] EOG8QC3NM GO:0005515 2/153 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QC3NM GO:0005886 2/153 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QC3NM GO:0007520 2/153 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8QC3NM GO:0007156 2/153 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8QC3NM GO:0001745 2/153 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8QC3NM GO:0005912 1/153 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8QC3NM GO:0036059 1/153 nephrocyte diaphragm assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] EOG8QC3NM GO:0097206 1/153 nephrocyte filtration biological_process "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] EOG8QC3NM GO:0007157 1/153 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8QC3NM GO:0030165 1/153 PDZ domain binding molecular_function "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] EOG8QC3NM GO:0016021 1/153 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QC3NM GO:0005913 1/153 cell-cell adherens junction cellular_component "An adherens junction which connects a cell to another cell." [GOC:hb] EOG8QC3NM GO:0046667 1/153 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG8QC3NM GO:0045177 1/153 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8QC3NM GO:0048749 1/153 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8QC3NM GO:0046666 1/153 retinal cell programmed cell death biological_process "Programmed cell death that occurs in the developing retina." [GOC:bf] EOG8QC3NM GO:0061321 1/153 garland nephrocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] EOG8QC3NM GO:0007523 1/153 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG8QC3NM GO:1901739 1/153 regulation of myoblast fusion biological_process "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] EOG8QC3NM GO:0005917 1/153 nephrocyte diaphragm cellular_component "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] EOG8QC3NM GO:0050839 1/153 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8QC3NM GO:0009986 1/153 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8QC3NM GO:0046331 1/153 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8QC3NM GO:0036058 1/153 filtration diaphragm assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929] EOG8KWN79 GO:0005794 33/98 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8KWN79 GO:0016021 33/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KWN79 GO:0006486 33/98 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8KWN79 GO:0008378 30/98 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8KWN79 GO:0047915 3/98 ganglioside galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] EOG8KWN79 GO:0016757 1/98 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8KWN79 GO:0008152 1/98 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8GXJ31 GO:0007268 2/173 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8GXJ31 GO:0017121 1/173 phospholipid scrambling biological_process "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864] EOG8GXJ31 GO:0048812 1/173 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8GXJ31 GO:0017128 1/173 phospholipid scramblase activity molecular_function "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864] EOG8MD0FT GO:0004725 1/45 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8ZW7T5 GO:0003676 28/39 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZW7T5 GO:0004527 13/39 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8ZW7T5 GO:0008310 1/39 single-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG8ZW7T5 GO:0000175 1/39 3'-5'-exoribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] EOG8ZW7T5 GO:0000738 1/39 DNA catabolic process, exonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG8ZW7T5 GO:0090503 1/39 RNA phosphodiester bond hydrolysis, exonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG8ZW7T5 GO:0008311 1/39 double-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG84QWHN GO:0008270 9/22 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84QWHN GO:0016491 1/22 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80P6MX GO:0016021 41/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86DPHT GO:0030060 1/9 L-malate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] EOG86DPHT GO:0044262 1/9 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG86DPHT GO:0006108 1/9 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG8MD0FD GO:0008270 80/289 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MD0FD GO:0005634 53/289 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MD0FD GO:0016568 52/289 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8MD0FD GO:0016573 33/289 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8MD0FD GO:0008285 32/289 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8MD0FD GO:0070776 31/289 MOZ/MORF histone acetyltransferase complex cellular_component "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358] EOG8MD0FD GO:0043486 1/289 histone exchange biological_process "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] EOG8MD0FD GO:0035267 1/289 NuA4 histone acetyltransferase complex cellular_component "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] EOG8MD0FD GO:0000123 1/289 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8MD0FD GO:0016773 1/289 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8MD0FD GO:0043065 1/289 positive regulation of apoptotic process biological_process "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8MD0FD GO:0070822 1/289 Sin3-type complex cellular_component "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] EOG8MD0FG GO:0007165 2/3 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8FFGHB GO:0006950 26/583 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8FFGHB GO:0005212 9/583 structural constituent of eye lens molecular_function "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] EOG8FFGHB GO:0008340 3/583 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8FFGHB GO:0005875 3/583 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8FFGHB GO:0010998 2/583 regulation of translational initiation by eIF2 alpha phosphorylation biological_process "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] EOG8FFGHB GO:0009631 2/583 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG8FFGHB GO:0005515 2/583 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FFGHB GO:0007275 1/583 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FFGHB GO:0017022 1/583 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8FFGHB GO:0042595 1/583 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8FFGHB GO:0009408 1/583 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8FFGHB GO:0007476 1/583 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FFGHB GO:0010506 1/583 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8FFGHB GO:0003779 1/583 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8FFGHB GO:0006497 1/583 protein lipidation biological_process "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] EOG8FFGHB GO:0001666 1/583 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8FFGHB GO:0006979 1/583 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8FFGHB GO:0031427 1/583 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FFGHB GO:0050832 1/583 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8FFGHB GO:0042742 1/583 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8MD0FC GO:0003676 1/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86DPHS GO:0006355 1/6 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86DPHS GO:0003723 1/6 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FTZFX GO:0016491 152/463 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8FTZFX GO:0016630 12/463 protochlorophyllide reductase activity molecular_function "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] EOG8FTZFX GO:0004316 2/463 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8X0Q7R GO:0003899 43/210 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8X0Q7R GO:0003677 43/210 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X0Q7R GO:0006351 43/210 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8X0Q7R GO:0003676 4/210 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X0Q7R GO:0046872 3/210 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X0Q7R GO:0008270 1/210 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X0Q7R GO:0005634 1/210 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WWV0G GO:0005524 4/41 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WWV0G GO:0004674 3/41 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8WWV0G GO:0004687 1/41 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8BS01X GO:0020037 23/68 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8BS01X GO:0046331 1/68 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8WWV0K GO:0005524 18/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FTZFT GO:0008270 21/90 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZFT GO:0003676 17/90 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZFT GO:0007427 1/90 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FTZFT GO:0016023 1/90 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG8FTZFT GO:0007015 1/90 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8FTZFT GO:0005886 1/90 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FTZFT GO:0007494 1/90 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8FTZFT GO:0060429 1/90 epithelium development biological_process "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] EOG8FTZFT GO:0040003 1/90 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8FTZFT GO:0008258 1/90 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8FTZFT GO:0007391 1/90 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FTZFT GO:0035282 1/90 segmentation biological_process "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] EOG8FTZFT GO:0045296 1/90 cadherin binding molecular_function "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] EOG8FTZFT GO:0048471 1/90 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8FTZFT GO:0016567 1/90 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8PRW6D GO:0016042 15/54 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8PRW6D GO:0004623 15/54 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG8PRW6D GO:0005509 15/54 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8PRW6D GO:0006644 9/54 phospholipid metabolic process biological_process "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8PRW6D GO:0005576 9/54 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BS01Q GO:0051260 26/96 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8BS01Q GO:0005886 1/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BS01Q GO:0004114 1/96 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG8MSGC0 GO:0004601 52/183 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8MSGC0 GO:0006979 52/183 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8MSGC0 GO:0020037 52/183 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8MSGC0 GO:0060967 1/183 negative regulation of gene silencing by RNA biological_process "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] EOG8MSGC0 GO:0016758 1/183 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8MSGC0 GO:0070189 1/183 kynurenine metabolic process biological_process "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph] EOG8MSGC0 GO:0005764 1/183 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8MSGC0 GO:1901216 1/183 positive regulation of neuron death biological_process "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] EOG8MSGC0 GO:0006727 1/183 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8FTZFJ GO:0016020 24/136 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FTZFJ GO:0016200 1/136 synaptic target attraction biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] EOG8FTZFJ GO:0007156 1/136 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8FTZFJ GO:0007413 1/136 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8FTZFJ GO:0007411 1/136 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FTZFJ GO:0030707 1/136 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FTZFJ GO:0005920 1/136 smooth septate junction cellular_component "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] EOG8FTZFJ GO:0007476 1/136 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FTZFJ GO:0007611 1/136 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8FTZFJ GO:0008355 1/136 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8FTZFJ GO:0008039 1/136 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8FTZFJ GO:0016021 1/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FTZFJ GO:0016323 1/136 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8FTZFJ GO:0031594 1/136 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8FTZFJ GO:0004252 1/136 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8FTZFJ GO:0016328 1/136 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG8FTZFJ GO:0005918 1/136 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8FTZFJ GO:0005886 1/136 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FTZFK GO:0003676 18/140 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FTZFK GO:0046872 18/140 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BS01J GO:0003676 32/94 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BS01J GO:0004527 8/94 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8BS01J GO:0008853 1/94 exodeoxyribonuclease III activity molecular_function "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] EOG8BS01J GO:0006950 1/94 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8MSGC6 GO:0003676 1/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MSGC6 GO:0006419 1/10 alanyl-tRNA aminoacylation biological_process "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8MSGC6 GO:0004813 1/10 alanine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] EOG8MSGC6 GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MSGC8 GO:0005622 24/92 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MSGC8 GO:0004198 24/92 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8MSGC8 GO:0005509 24/92 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8MSGC8 GO:0005737 1/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WWV0X GO:0004930 20/67 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8WWV0X GO:0016021 20/67 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WWV0X GO:0007218 2/67 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8WWV0X GO:0050254 1/67 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8WWV0X GO:0007186 1/67 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8WWV0X GO:0008188 1/67 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8PRW6R GO:0016491 44/293 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8PRW6R GO:0004022 8/293 alcohol dehydrogenase (NAD) activity molecular_function "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] EOG8PRW6R GO:0016404 4/293 15-hydroxyprostaglandin dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] EOG8PRW6R GO:0003939 1/293 L-iditol 2-dehydrogenase activity molecular_function "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] EOG8PRW6R GO:0006066 1/293 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8DV831 GO:0005506 14/79 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8DV831 GO:0020037 14/79 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8DV831 GO:0019825 14/79 oxygen binding molecular_function "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] EOG8DV831 GO:0005344 13/79 oxygen transporter activity molecular_function "Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai] EOG8DV831 GO:0015671 1/79 oxygen transport biological_process "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8B014Z GO:0016020 27/111 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8B014Z GO:0046873 27/111 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8GB9P2 GO:0006030 6/7 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8GB9P2 GO:0008061 6/7 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8GB9P2 GO:0005576 6/7 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG89W4VM GO:0005524 27/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89W4VM GO:0006457 26/95 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG89W4VM GO:0005737 25/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89W4VM GO:0044267 1/95 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG89W4VM GO:0006200 1/95 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG89W4VM GO:0007052 1/95 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG89W4VM GO:0005875 1/95 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG89W4VM GO:0022008 1/95 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG89W4VM GO:0005832 1/95 chaperonin-containing T-complex cellular_component "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] EOG89W4VM GO:0042623 1/95 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8P8HXV GO:0015031 2/97 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8P8HXW GO:0005097 25/111 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8P8HXW GO:0033627 1/111 cell adhesion mediated by integrin biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] EOG8P8HXW GO:0009986 1/111 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8P8HXW GO:0005178 1/111 integrin binding molecular_function "Interacting selectively and non-covalently with an integrin." [GOC:ceb] EOG89W4VV GO:0030554 2/15 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG89W4VV GO:0003938 2/15 IMP dehydrogenase activity molecular_function "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] EOG89W4VV GO:0005737 1/15 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89W4VV GO:0046872 1/15 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89W4VV GO:0006164 1/15 purine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG89W4VV GO:0006177 1/15 GMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] EOG8B014C GO:0008299 2/12 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8B014C GO:0016740 1/12 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8B014C GO:0004311 1/12 farnesyltranstransferase activity molecular_function "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17656] EOG8B014F GO:0003700 21/72 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8B014F GO:0043565 21/72 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8B014F GO:0005634 21/72 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8B014F GO:0004000 1/72 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8B014F GO:0003677 1/72 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B014F GO:0048813 1/72 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8B0148 GO:0008233 3/38 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8B0148 GO:0004180 1/38 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG88GZH9 GO:0003700 29/122 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88GZH9 GO:0004871 29/122 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG88GZH9 GO:0005634 29/122 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88GZH9 GO:0005509 28/122 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG88GZH9 GO:0005737 24/122 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88GZH9 GO:0003677 24/122 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88GZH9 GO:0006351 23/122 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88GZH9 GO:0030097 1/122 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG88GZH9 GO:0007530 1/122 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG88GZH9 GO:0006952 1/122 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG88GZH9 GO:0048749 1/122 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG88GZH9 GO:0001077 1/122 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG88GZH9 GO:0002230 1/122 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG88GZH9 GO:0005515 1/122 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88GZH9 GO:0071481 1/122 cellular response to X-ray biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] EOG88GZH9 GO:0045944 1/122 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG88GZH9 GO:0048103 1/122 somatic stem cell division biological_process "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] EOG88GZH9 GO:0008284 1/122 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG88GZH9 GO:0035019 1/122 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG88GZH9 GO:0007476 1/122 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG88GZH9 GO:0007424 1/122 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG88GZH9 GO:0007538 1/122 primary sex determination biological_process "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] EOG88GZH9 GO:0035167 1/122 larval lymph gland hemopoiesis biological_process "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] EOG88GZH9 GO:0019827 1/122 stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] EOG88GZH9 GO:0035172 1/122 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG88GZH9 GO:0007399 1/122 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG88GZH9 GO:0043697 1/122 cell dedifferentiation biological_process "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] EOG88GZH9 GO:0007259 1/122 JAK-STAT cascade biological_process "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] EOG88GZH9 GO:0017145 1/122 stem cell division biological_process "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] EOG88GZH9 GO:0046425 1/122 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG88GZH9 GO:0007526 1/122 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG88GZH9 GO:0030178 1/122 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG88GZH9 GO:0048477 1/122 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG88GZH9 GO:0071222 1/122 cellular response to lipopolysaccharide biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah] EOG88GZH9 GO:0007616 1/122 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG88GZH9 GO:0007379 1/122 segment specification biological_process "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG88GZH9 GO:0035171 1/122 lamellocyte differentiation biological_process "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] EOG88GZH9 GO:0007442 1/122 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG88GZH9 GO:0007350 1/122 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG88GZH9 GO:0008348 1/122 negative regulation of antimicrobial humoral response biological_process "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] EOG88GZH9 GO:0042078 1/122 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG88GZH9 GO:0006959 1/122 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG88GZH9 GO:0007455 1/122 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG88GZH9 GO:0007425 1/122 epithelial cell fate determination, open tracheal system biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] EOG88GZH9 GO:0007298 1/122 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG88GZH9 GO:0030720 1/122 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG88GZH9 GO:0030713 1/122 ovarian follicle cell stalk formation biological_process "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG88GZH9 GO:0030718 1/122 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG89W4V7 GO:0005634 3/113 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89W4V7 GO:0005216 1/113 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG89W4V7 GO:0016021 1/113 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86T5HQ GO:0015411 1/3 taurine-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36] EOG86T5HQ GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86T5HQ GO:0015734 1/3 taurine transport biological_process "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG86T5HQ GO:0016020 1/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BS014 GO:0030170 2/7 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8BS014 GO:0009058 2/7 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8BS014 GO:0003824 1/7 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8BS014 GO:0008483 1/7 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8BS014 GO:0015288 1/7 porin activity molecular_function "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] EOG8BS014 GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BS013 GO:0006030 6/38 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8BS013 GO:0005576 6/38 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BS013 GO:0008061 6/38 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8ZW7S8 GO:0003824 1/78 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8WWV09 GO:0003824 1/13 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8WWV09 GO:0008299 1/13 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8PRW65 GO:0051536 4/17 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8PRW65 GO:0004109 3/17 coproporphyrinogen oxidase activity molecular_function "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260] EOG8PRW65 GO:0006779 3/17 porphyrin-containing compound biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] EOG8PRW65 GO:0005737 3/17 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PRW65 GO:0051989 2/17 coproporphyrinogen dehydrogenase activity molecular_function "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22] EOG83JFMN GO:0051260 26/89 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG83JFMN GO:0004114 1/89 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG83JFMC GO:0003755 1/5 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG83JFMC GO:0006457 1/5 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8284H9 GO:0008061 41/102 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8284H9 GO:0005576 41/102 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8284H9 GO:0006030 41/102 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87H853 GO:0004497 1/3 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG87H853 GO:0005506 1/3 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG87H853 GO:0016705 1/3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG87H853 GO:0020037 1/3 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG87Q0PD GO:0003735 27/91 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG87Q0PD GO:0005840 27/91 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG87Q0PD GO:0006414 27/91 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8DNHKD GO:0005975 1/7 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8DNHKD GO:0000287 1/7 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8DNHKD GO:0042558 1/7 pteridine-containing compound metabolic process biological_process "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] EOG8DNHKD GO:0008966 1/7 phosphoglucosamine mutase activity molecular_function "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23427] EOG83FKD0 GO:0005737 3/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83FKD0 GO:0006886 2/94 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG83FKD0 GO:0090382 1/94 phagosome maturation biological_process "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] EOG83FKD0 GO:0090385 1/94 phagosome-lysosome fusion biological_process "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb] EOG83FKD0 GO:0006955 1/94 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG83FKD0 GO:0016197 1/94 endosomal transport biological_process "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732] EOG83FKD0 GO:0005515 1/94 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83FKD0 GO:0035542 1/94 regulation of SNARE complex assembly biological_process "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] EOG83FKD0 GO:0030897 1/94 HOPS complex cellular_component "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] EOG83FKD0 GO:0033263 1/94 CORVET complex cellular_component "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] EOG8284H5 GO:0016021 71/178 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WHC4H GO:0055085 1/3 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8WHC4H GO:0009306 1/3 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG8WHC4H GO:0016020 1/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GXJ5K GO:0020037 5/12 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8GXJ5K GO:0005506 5/12 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8GXJ5K GO:0016705 2/12 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8GXJ5K GO:0070330 1/12 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8GXJ5K GO:0018685 1/12 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG8GXJ5K GO:0052869 1/12 arachidonic acid omega-hydroxylase activity molecular_function "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041] EOG8GXJ5K GO:0052871 1/12 alpha-tocopherol omega-hydroxylase activity molecular_function "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] EOG8GXJ5K GO:0050051 1/12 leukotriene-B4 20-monooxygenase activity molecular_function "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] EOG86X1PM GO:0004725 23/128 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG86X1PM GO:0005737 3/128 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86X1PM GO:0007362 2/128 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1PM GO:0050254 2/128 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG86X1PM GO:0008293 2/128 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG86X1PM GO:0016311 1/128 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG86X1PM GO:0006911 1/128 phagocytosis, engulfment biological_process "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] EOG86X1PM GO:0007418 1/128 ventral midline development biological_process "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] EOG86X1PM GO:0005515 1/128 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86X1PM GO:0007498 1/128 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG86X1PM GO:0045500 1/128 sevenless signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085] EOG86X1PM GO:0008543 1/128 fibroblast growth factor receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] EOG86X1PM GO:0004726 1/128 non-membrane spanning protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] EOG86X1PM GO:0007427 1/128 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG86X1PM GO:0007428 1/128 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG86X1PM GO:0043066 1/128 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG86X1PM GO:0035335 1/128 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG86X1PM GO:0007465 1/128 R7 cell fate commitment biological_process "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG86X1PM GO:0000278 1/128 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG86X1PM GO:0007444 1/128 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG86X1PM GO:0007173 1/128 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG86X1PM GO:0008595 1/128 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1PM GO:0045314 1/128 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG86X1PM GO:0004728 1/128 receptor signaling protein tyrosine phosphatase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG86X1PM GO:0007424 1/128 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG86X1PM GO:0006470 1/128 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG86X1PM GO:0023014 1/128 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG86X1PM GO:0008069 1/128 dorsal/ventral axis specification, ovarian follicular epithelium biological_process "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8QVFTV GO:0005634 10/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QVFTV GO:0003700 10/97 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8QVFTV GO:0003677 1/97 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QVFTV GO:0000122 1/97 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8QVFTV GO:0006355 1/97 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8QVFTV GO:0006351 1/97 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8QVFTV GO:0046982 1/97 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG84F8SJ GO:0016192 1/4 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG84F8SJ GO:0006886 1/4 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG84F8SJ GO:0030131 1/4 clathrin adaptor complex cellular_component "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] EOG86X1PS GO:0016747 73/270 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG86X1PS GO:0003985 5/270 acetyl-CoA C-acetyltransferase activity molecular_function "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] EOG86X1PS GO:0005811 2/270 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG86X1PS GO:0005739 2/270 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86X1PS GO:0005875 2/270 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG86X1PS GO:0005777 1/270 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG86X1PS GO:0007052 1/270 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG86X1PS GO:0003988 1/270 acetyl-CoA C-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] EOG8QVFTZ GO:0045475 1/86 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8QVFTZ GO:0048699 1/86 generation of neurons biological_process "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] EOG8QVFTZ GO:0010628 1/86 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8QVFTZ GO:0006355 1/86 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82RGP9 GO:0005634 16/49 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82RGP9 GO:0003707 16/49 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG82RGP9 GO:0003700 15/49 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82RGP9 GO:0006351 15/49 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82RGP9 GO:0008270 15/49 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82RGP9 GO:0043565 15/49 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82RGP9 GO:0004879 1/49 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG82RGP9 GO:0030522 1/49 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG8R26BQ GO:0003676 3/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R26BQ GO:0008270 1/14 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R26BQ GO:0005634 1/14 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84F8S1 GO:0008270 1/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG86X1P9 GO:0006355 15/45 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86X1P9 GO:0004871 15/45 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG86X1P9 GO:0003677 15/45 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86X1P9 GO:0005634 15/45 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86X1P9 GO:0006351 15/45 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86X1P9 GO:0030374 1/45 ligand-dependent nuclear receptor transcription coactivator activity molecular_function "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] EOG86X1P9 GO:0007298 1/45 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG86X1P9 GO:0060250 1/45 germ-line stem-cell niche homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] EOG86X1P9 GO:0035258 1/45 steroid hormone receptor binding molecular_function "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf] EOG86X1P9 GO:0048675 1/45 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8B0134 GO:0005977 29/107 glycogen metabolic process biological_process "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] EOG8B0134 GO:0004553 26/107 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8B0134 GO:0016301 5/107 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8B0134 GO:0005886 1/107 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QVFT1 GO:0006457 1/40 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG87Q0NW GO:0006457 25/72 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG87Q0NW GO:0016272 25/72 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG8QVFT9 GO:0005549 3/25 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8XH2GK GO:0005634 21/50 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2GK GO:0006355 20/50 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8XH2GK GO:0003677 1/50 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XH2GK GO:0016204 1/50 determination of muscle attachment site biological_process "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] EOG8XH2GK GO:0007451 1/50 dorsal/ventral lineage restriction, imaginal disc biological_process "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] EOG8XH2GK GO:0007346 1/50 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8XH2GK GO:0007049 1/50 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8XH2GK GO:0048190 1/50 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8XH2GK GO:0006260 1/50 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8XH2GK GO:0007525 1/50 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8XH2GK GO:0044719 1/50 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG8XH2GK GO:0007480 1/50 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8XH2GK GO:0007473 1/50 wing disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] EOG8XH2GK GO:0007476 1/50 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8XH2GK GO:0008022 1/50 protein C-terminus binding molecular_function "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] EOG8XH2GK GO:0035220 1/50 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8XH2GK GO:0045944 1/50 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8XH2GK GO:0001745 1/50 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8XH2GK GO:0005515 1/50 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XH2GK GO:0042127 1/50 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8XH2GK GO:0008587 1/50 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8XH2GK GO:0005524 1/50 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XH2GK GO:0006366 1/50 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8XH2GK GO:0007472 1/50 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8XH2GK GO:0007482 1/50 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8DBWTN GO:0005216 8/47 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8DBWTN GO:0016021 8/47 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWTN GO:0005509 1/47 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DBWTC GO:0016881 1/48 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8284HD GO:0003864 1/6 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] EOG8284HD GO:0015940 1/6 pantothenate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] EOG83FKDZ GO:0016020 1/45 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG89W4X1 GO:0016021 70/141 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89W4X1 GO:0006886 41/141 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG89W4X1 GO:0005744 41/141 mitochondrial inner membrane presequence translocase complex cellular_component "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659] EOG89W4X1 GO:0015450 37/141 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] EOG89W4X1 GO:0008566 4/141 mitochondrial protein-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] EOG89W4X1 GO:0005739 1/141 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG89W4X1 GO:0006626 1/141 protein targeting to mitochondrion biological_process "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] EOG8DBWTW GO:0016021 122/391 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWTW GO:0022857 118/391 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8DBWTW GO:0055085 3/391 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8DBWTW GO:0005215 2/391 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8DBWTW GO:0007390 1/391 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8DBWTW GO:0008643 1/391 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8DBWTW GO:0015695 1/391 organic cation transport biological_process "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] EOG8DBWTW GO:0030307 1/391 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8DBWTW GO:0015101 1/391 organic cation transmembrane transporter activity molecular_function "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8DBWTW GO:0040018 1/391 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8DBWTW GO:0006915 1/391 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8DBWTW GO:0006811 1/391 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8DBWTW GO:0032440 1/391 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8DBWTT GO:0017150 25/88 tRNA dihydrouridine synthase activity molecular_function "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] EOG8DBWTT GO:0050660 25/88 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG854CCM GO:0005739 1/95 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG854CCM GO:0016226 1/95 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG854CCM GO:0008199 1/95 ferric iron binding molecular_function "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] EOG854CCM GO:0004322 1/95 ferroxidase activity molecular_function "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] EOG8TXF7C GO:0003676 5/113 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TXF7C GO:0003677 1/113 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80CKXS GO:0006412 25/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG80CKXS GO:0003735 25/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG80CKXS GO:0015934 24/87 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG80CKXS GO:0005762 1/87 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG80CKXT GO:0055085 25/104 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG80CKXT GO:0016021 25/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80CKXT GO:0042302 1/104 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG854CCK GO:0006298 28/99 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG854CCK GO:0005524 28/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG854CCK GO:0030983 27/99 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG854CCK GO:0032301 10/99 MutSalpha complex cellular_component "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] EOG854CCK GO:0032302 10/99 MutSbeta complex cellular_component "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] EOG854CCK GO:0000228 1/99 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG854CCK GO:0032138 1/99 single base insertion or deletion binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] EOG854CCK GO:0000400 1/99 four-way junction DNA binding molecular_function "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] EOG854CCK GO:0010224 1/99 response to UV-B biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] EOG854CCK GO:0008094 1/99 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG854CCK GO:0000404 1/99 heteroduplex DNA loop binding molecular_function "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] EOG854CCK GO:0010165 1/99 response to X-ray biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] EOG854CCK GO:0000406 1/99 double-strand/single-strand DNA junction binding molecular_function "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] EOG854CCK GO:0006311 1/99 meiotic gene conversion biological_process "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] EOG854CCK GO:0003677 1/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG854CCK GO:0003684 1/99 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG854CCK GO:0045128 1/99 negative regulation of reciprocal meiotic recombination biological_process "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb] EOG854CCK GO:0031573 1/99 intra-S DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw] EOG854CCK GO:0006200 1/99 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG854CCK GO:0000710 1/99 meiotic mismatch repair biological_process "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] EOG854CCK GO:0006302 1/99 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG854CCK GO:0036297 1/99 interstrand cross-link repair biological_process "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477] EOG854CCK GO:0006301 1/99 postreplication repair biological_process "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] EOG854CCK GO:0042771 1/99 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG854CCK GO:0000403 1/99 Y-form DNA binding molecular_function "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] EOG854CCK GO:0032137 1/99 guanine/thymine mispair binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk] EOG854CCK GO:0043570 1/99 maintenance of DNA repeat elements biological_process "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] EOG854CCK GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG854CCD GO:0006511 26/111 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG854CCD GO:0031461 25/111 cullin-RING ubiquitin ligase complex cellular_component "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] EOG854CCD GO:0001745 1/111 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG854CCD GO:0007291 1/111 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG854CCD GO:0007409 1/111 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG854CCD GO:0007476 1/111 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG854CCD GO:0006919 1/111 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG854CCD GO:0005737 1/111 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG854CCD GO:0007283 1/111 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG854CCD GO:0007423 1/111 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG854CCD GO:0004842 1/111 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG854CCD GO:0030431 1/111 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG854CCD GO:0030162 1/111 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG854CCD GO:0031463 1/111 Cul3-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] EOG854CCD GO:0016567 1/111 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG854CCD GO:0045475 1/111 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG854CCD GO:0045187 1/111 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG854CCD GO:0048813 1/111 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8WQ3K4 GO:0032504 1/115 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8WQ3K4 GO:0005615 1/115 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Q2GW0 GO:0000184 26/94 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8TXF7Q GO:0004129 29/141 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8TXF7Q GO:0005739 28/141 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8TXF7Q GO:0008340 1/141 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8TXF7Q GO:0022008 1/141 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG893610 GO:0003700 20/51 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG893610 GO:0043565 20/51 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG893610 GO:0005634 20/51 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG893610 GO:0022008 1/51 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG854CCZ GO:0046872 2/30 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG822D19 GO:0004930 5/10 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG822D19 GO:0016021 5/10 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG822D19 GO:0005886 5/10 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8K3P9D GO:0003677 1/6 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8K3P9D GO:0003899 1/6 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8K3P9D GO:0006351 1/6 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8K3P9D GO:0032549 1/6 ribonucleoside binding molecular_function "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] EOG81VNHR GO:0070700 1/111 BMP receptor binding molecular_function "Interacting selectively and non-covalently with a BMP receptor." [GOC:BHF, GOC:vk] EOG81VNHR GO:0047712 1/111 Cypridina-luciferin 2-monooxygenase activity molecular_function "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] EOG81VNHR GO:0009986 1/111 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG81VNHR GO:0007474 1/111 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG81VNHR GO:0043395 1/111 heparan sulfate proteoglycan binding molecular_function "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732] EOG81VNHR GO:0007476 1/111 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG81VNHR GO:0036122 1/111 BMP binding molecular_function "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034] EOG81VNHR GO:0030510 1/111 regulation of BMP signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] EOG8GQSJR GO:0005622 22/97 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8GQSJR GO:0007165 22/97 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8GQSJR GO:0005096 21/97 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8GQSJR GO:0051056 21/97 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8GQSJR GO:0009408 1/97 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8GQSJR GO:0045886 1/97 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8GQSJR GO:0031235 1/97 intrinsic component of the cytoplasmic side of the plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah] EOG8GQSJR GO:0005099 1/97 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8GQSJR GO:0042066 1/97 perineurial glial growth biological_process "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560] EOG8GQSJR GO:0046580 1/97 negative regulation of Ras protein signal transduction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8GQSJR GO:0040018 1/97 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8GQSJR GO:0032320 1/97 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8GQSJR GO:0046578 1/97 regulation of Ras protein signal transduction biological_process "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8GQSJR GO:0045762 1/97 positive regulation of adenylate cyclase activity biological_process "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] EOG8GQSJR GO:0007614 1/97 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8GQSJR GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GQSJR GO:0019933 1/97 cAMP-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG8GQSJR GO:0040014 1/97 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8GQSJR GO:0007265 1/97 Ras protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] EOG8GQSJR GO:0008355 1/97 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8GQSJR GO:0008340 1/97 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8GQSJR GO:0007616 1/97 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8GQSJR GO:0045475 1/97 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8GQSJR GO:0006979 1/97 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8CVJP6 GO:0016758 34/154 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8QJV5J GO:0016021 23/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV5J GO:0004965 22/129 G-protein coupled GABA receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] EOG8QJV5J GO:0007186 1/129 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG82FVZW GO:0008903 26/87 hydroxypyruvate isomerase activity molecular_function "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11955] EOG82FVZW GO:0046487 1/87 glyoxylate metabolic process biological_process "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] EOG82FVZW GO:0005576 1/87 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81VNH5 GO:0030976 27/97 thiamine pyrophosphate binding molecular_function "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg] EOG81VNH5 GO:0000287 26/97 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG81VNH5 GO:0003824 19/97 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81VNH5 GO:0008949 4/97 oxalyl-CoA decarboxylase activity molecular_function "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19336] EOG81VNH5 GO:0016829 3/97 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG81VNH5 GO:0005777 1/97 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG81VNH5 GO:0070140 1/97 SUMO-specific isopeptidase activity molecular_function "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah] EOG8CVJPP GO:0005543 1/13 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8CVJPD GO:0016021 3/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CVJPD GO:0055085 3/8 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8CVJPD GO:0008643 1/8 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8SR0C4 GO:0046872 59/198 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SR0C4 GO:0004784 57/198 superoxide dismutase activity molecular_function "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] EOG8SR0C4 GO:0005737 11/198 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SR0C4 GO:0006801 4/198 superoxide metabolic process biological_process "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] EOG8SR0C4 GO:0055114 4/198 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8SR0C4 GO:0005507 2/198 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8SR0C4 GO:0008270 2/198 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR0C4 GO:0019430 2/198 removal of superoxide radicals biological_process "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl] EOG8SR0C4 GO:0006979 2/198 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8SR0C4 GO:0005615 1/198 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8SR0C4 GO:0016209 1/198 antioxidant activity molecular_function "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] EOG8SR0C4 GO:0005777 1/198 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8SR0C4 GO:0007568 1/198 aging biological_process "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] EOG8SR0C4 GO:0042803 1/198 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8SR0C4 GO:0008340 1/198 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8SR0C4 GO:0009650 1/198 UV protection biological_process "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] EOG83FKD9 GO:0006030 24/74 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG83FKD9 GO:0008061 24/74 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG83FKD9 GO:0005576 24/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80CKX9 GO:0050660 12/64 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG80CKX9 GO:0008812 11/64 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG80CKX9 GO:0006066 11/64 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG80CKX9 GO:0004344 1/64 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG80CKX9 GO:0016614 1/64 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8935XT GO:0016021 22/122 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8935XT GO:0005216 21/122 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8935XT GO:0005840 1/122 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8935XT GO:0070588 1/122 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8935XT GO:0006412 1/122 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8935XT GO:0007605 1/122 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8935XT GO:0009270 1/122 response to humidity biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] EOG8935XT GO:0003735 1/122 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8935XT GO:0005262 1/122 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8935XT GO:0006816 1/122 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8935XT GO:0004623 1/122 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG8K3P96 GO:0008270 28/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K3P96 GO:0035556 1/97 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8K3P96 GO:0003676 1/97 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K3P96 GO:0016021 1/97 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K3P96 GO:0055085 1/97 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8K3P96 GO:0046331 1/97 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG812PP6 GO:0008270 1/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG812PP6 GO:0003677 1/12 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84QWGG GO:0003677 13/47 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84QWGG GO:0003676 4/47 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84QWGG GO:0046872 2/47 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83N9TJ GO:0005506 404/1184 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83N9TJ GO:0020037 404/1184 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83N9TJ GO:0016705 391/1184 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83N9TJ GO:0004497 374/1184 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83N9TJ GO:0005789 17/1184 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG83N9TJ GO:0070330 6/1184 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG83N9TJ GO:0052869 6/1184 arachidonic acid omega-hydroxylase activity molecular_function "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041] EOG83N9TJ GO:0018685 6/1184 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG83N9TJ GO:0016539 3/1184 intein-mediated protein splicing biological_process "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] EOG83N9TJ GO:0007165 2/1184 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG83N9TJ GO:0005622 2/1184 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83N9TJ GO:0007618 1/1184 mating biological_process "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] EOG83N9TJ GO:0005201 1/1184 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG83N9TJ GO:0005581 1/1184 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG83N9TJ GO:0050051 1/1184 leukotriene-B4 20-monooxygenase activity molecular_function "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] EOG83N9TJ GO:0052871 1/1184 alpha-tocopherol omega-hydroxylase activity molecular_function "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] EOG83N9TJ GO:0006629 1/1184 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG83N9TJ GO:0005737 1/1184 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83N9TJ GO:0005811 1/1184 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8Z38TH GO:0003676 2/152 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z38TH GO:0016788 2/152 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8Z38TH GO:0019090 1/152 mitochondrial rRNA export from mitochondrion biological_process "The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai] EOG8Z38TH GO:0046872 1/152 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Z38TH GO:0045495 1/152 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG8Z38TH GO:0030719 1/152 P granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] EOG8Z38TH GO:0008168 1/152 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8Z38TH GO:0005737 1/152 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z38TH GO:0043186 1/152 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8Z38TH GO:0007281 1/152 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8Z38TH GO:0003677 1/152 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Z38TH GO:0006306 1/152 DNA methylation biological_process "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] EOG8Z38TH GO:0007277 1/152 pole cell development biological_process "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] EOG8Z38TH GO:0003723 1/152 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Z38TH GO:0008298 1/152 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8Z38TH GO:0005739 1/152 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Z38TH GO:0005515 1/152 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8Z38TH GO:0005634 1/152 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z38TH GO:0007315 1/152 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG89PDFN GO:0005549 1/113 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8FR36V GO:0008270 1/8 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG866Z1C GO:0008270 26/120 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG866Z1C GO:0048813 1/120 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG866Z1C GO:0007517 1/120 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG866Z1C GO:0046872 1/120 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG866Z1C GO:0006909 1/120 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8Q87CR GO:0004609 26/93 phosphatidylserine decarboxylase activity molecular_function "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20831] EOG8Q87CR GO:0008654 26/93 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8Q87CR GO:0016021 1/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QFZV0 GO:0005737 1/9 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QFZV0 GO:0008033 1/9 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8QFZV0 GO:0016783 1/9 sulfurtransferase activity molecular_function "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] EOG8QFZV3 GO:0005975 201/525 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8QFZV3 GO:0043169 199/525 cation binding molecular_function "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] EOG8QFZV3 GO:0003824 188/525 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QFZV3 GO:0032450 12/525 maltose alpha-glucosidase activity molecular_function "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] EOG8QFZV3 GO:0016740 1/525 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8QFZV3 GO:0003677 1/525 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CG2Q6 GO:0016757 25/179 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8CG2Q6 GO:0006810 4/179 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8CG2Q6 GO:0016021 4/179 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CG2Q6 GO:0004578 2/179 chitobiosyldiphosphodolichol beta-mannosyltransferase activity molecular_function "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] EOG8CG2Q6 GO:0018024 1/179 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8PVRFT GO:0005507 27/100 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8PVRFT GO:0055070 27/100 copper ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] EOG8CG2Q8 GO:0006281 2/8 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8CG2Q8 GO:0006310 2/8 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8CG2Q8 GO:0003676 2/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CG2Q8 GO:0008821 2/8 crossover junction endodeoxyribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] EOG86MF21 GO:0005509 17/80 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TB6RS GO:0008616 1/7 queuosine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732] EOG8TB6RS GO:0008479 1/7 queuine tRNA-ribosyltransferase activity molecular_function "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] EOG8TB6RH GO:0005509 4/21 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TB6RH GO:0005216 3/21 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8TB6RH GO:0016021 3/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z1T GO:0001522 3/30 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG866Z1T GO:0009982 3/30 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG866Z1T GO:0003723 3/30 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG89PDF5 GO:0001682 1/49 tRNA 5'-leader removal biological_process "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] EOG89PDF5 GO:0004526 1/49 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8N337M GO:0003723 5/12 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8N337M GO:0003964 5/12 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8G1PWV GO:0008061 19/43 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8G1PWV GO:0005576 19/43 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8G1PWV GO:0006030 19/43 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8G1PWV GO:0031012 1/43 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8G1PWV GO:0005201 1/43 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8W10TN GO:0016021 5/18 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W10TN GO:0004930 5/18 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FFGG0 GO:0006310 1/8 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8FFGG0 GO:0003676 1/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FFGG0 GO:0006281 1/8 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8FFGG0 GO:0008409 1/8 5'-3' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] EOG8FFGG0 GO:0030145 1/8 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG8NKF90 GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NKF90 GO:0009058 1/10 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8NKF90 GO:0016874 1/10 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8NKF91 GO:0004871 39/124 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8NKF91 GO:0006351 34/124 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8NKF91 GO:0005634 34/124 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NKF91 GO:0003677 33/124 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NKF91 GO:0006355 20/124 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NKF91 GO:0003700 16/124 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NKF91 GO:0005667 16/124 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8NKF91 GO:0005737 16/124 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKF91 GO:0046982 2/124 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8NKF91 GO:0045944 2/124 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NKF91 GO:0008134 2/124 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8NKF91 GO:0043069 2/124 negative regulation of programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8NKF91 GO:0042803 1/124 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8NKF91 GO:0005500 1/124 juvenile hormone binding molecular_function "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] EOG8NKF91 GO:0050793 1/124 regulation of developmental process biological_process "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] EOG8NKF92 GO:0005524 101/307 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NKF92 GO:0005737 101/307 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKF92 GO:0005856 95/307 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8NKF92 GO:0007010 6/307 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8NKF92 GO:0005200 6/307 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8NKF92 GO:0005884 6/307 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG8NKF92 GO:0000281 3/307 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8NKF92 GO:0005875 3/307 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NKF92 GO:0006909 3/307 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8NKF92 GO:0005811 2/307 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8NKF92 GO:0031011 1/307 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG8NKF92 GO:0002121 1/307 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8NKF92 GO:0016319 1/307 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8NKF92 GO:0051297 1/307 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8NKF92 GO:0007507 1/307 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8NKF92 GO:0014866 1/307 skeletal myofibril assembly biological_process "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] EOG8NKF92 GO:0007291 1/307 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8NKF92 GO:0032507 1/307 maintenance of protein location in cell biological_process "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] EOG8NKF92 GO:0051533 1/307 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8NKF93 GO:0005634 24/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NKF93 GO:0004402 2/93 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8HB127 GO:0008113 2/5 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG8HB127 GO:0006979 2/5 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8HB127 GO:0030091 2/5 protein repair biological_process "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] EOG8FFGG9 GO:0008922 1/5 long-chain fatty acid [acyl-carrier-protein] ligase activity molecular_function "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.20] EOG8MD0GP GO:0005576 6/31 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8MD0GP GO:0030414 6/31 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG80VZ5R GO:0046872 3/8 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8K6JJG GO:0005524 37/100 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K6JJG GO:0042026 36/100 protein refolding biological_process "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] EOG8K6JJG GO:0005737 34/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K6JJG GO:0005759 2/100 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8K6JJG GO:0006950 2/100 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8K6JJG GO:0007283 1/100 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8K6JJG GO:0005811 1/100 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8K6JJG GO:0044267 1/100 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG8K6JJG GO:0007424 1/100 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8K6JJG GO:0030707 1/100 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8K6JJG GO:0005875 1/100 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8K6JJG GO:0005743 1/100 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8K6JJG GO:0007301 1/100 female germline ring canal formation biological_process "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] EOG8K6JJG GO:0005739 1/100 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8K6JJG GO:0007005 1/100 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8K6JJG GO:0034605 1/100 cellular response to heat biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] EOG8K6JJG GO:0048477 1/100 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8K6JJK GO:0008168 24/87 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8K6JJK GO:0003676 21/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K6JJK GO:0006370 1/87 7-methylguanosine mRNA capping biological_process "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] EOG8K6JJK GO:0004483 1/87 mRNA (nucleoside-2'-O-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] EOG8K6JJK GO:0005524 1/87 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K6JJK GO:0097309 1/87 cap1 mRNA methylation biological_process "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356] EOG8K6JJK GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K6JJK GO:0080009 1/87 mRNA methylation biological_process "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] EOG8W10TT GO:0016021 26/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W10TT GO:0004930 25/124 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8W10TT GO:0004993 3/124 serotonin receptor activity molecular_function "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] EOG8W10TT GO:0007626 2/124 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8W10TT GO:0005887 2/124 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W10TT GO:0007631 2/124 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8W10TT GO:0007210 1/124 serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] EOG80VZ5F GO:0016887 2/21 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG80VZ5F GO:0005215 2/21 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG80VZ5F GO:0005524 2/21 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80VZ5F GO:0016021 2/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MD0GC GO:0004385 1/13 guanylate kinase activity molecular_function "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] EOG8MD0GC GO:0006163 1/13 purine nucleotide metabolic process biological_process "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8HB12Z GO:0005576 4/48 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HB12Z GO:0009405 3/48 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8HB12Z GO:0008200 3/48 ion channel inhibitor activity molecular_function "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] EOG8HB12Z GO:0009755 1/48 hormone-mediated signaling pathway biological_process "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] EOG8FFGGP GO:0009058 1/13 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8FFGGP GO:0016779 1/13 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8NKF9P GO:0005576 1/107 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF9Q GO:0016020 55/747 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NKF9Q GO:0007157 8/747 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8NKF9Q GO:0005887 3/747 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF9Q GO:0007415 2/747 defasciculation of motor neuron axon biological_process "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] EOG8NKF9Q GO:0007411 2/747 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8NKF9Q GO:0004252 2/747 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8NKF9Q GO:0005576 1/747 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF9Q GO:0005515 1/747 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NKF9Q GO:0001746 1/747 Bolwig's organ morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] EOG8NKF9Q GO:0016198 1/747 axon choice point recognition biological_process "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] EOG8NKF9Q GO:0008045 1/747 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8NKF9Q GO:0016201 1/747 synaptic target inhibition biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] EOG8NKF9Q GO:0031225 1/747 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8FFGGX GO:0044249 1/3 cellular biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] EOG80VZ53 GO:0007605 1/102 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG80VZ53 GO:0022008 1/102 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8NKF9W GO:0005549 31/63 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NKF9W GO:0005576 3/63 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF9W GO:0007606 3/63 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8T4G8S GO:0006355 38/115 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8T4G8S GO:0005622 38/115 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8FFGGB GO:0016021 20/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGB GO:0004930 10/129 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FFGGB GO:0016499 5/129 orexin receptor activity molecular_function "Combining with orexin to initiate a change in cell activity." [GOC:ai] EOG8FFGGB GO:0007631 5/129 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8FFGGB GO:0004983 5/129 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8FFGGB GO:0004715 1/129 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8FFGGB GO:0003723 1/129 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FFGGB GO:0050254 1/129 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8FFGGB GO:0003964 1/129 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8HB12C GO:0005700 1/145 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8HB12C GO:0044666 1/145 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8HB12C GO:0071557 1/145 histone H3-K27 demethylation biological_process "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638] EOG8HB12C GO:0045746 1/145 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8HB12C GO:1902465 1/145 negative regulation of histone H3-K27 trimethylation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] EOG8HB12C GO:0061086 1/145 negative regulation of histone H3-K27 methylation biological_process "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] EOG8HB12C GO:0042060 1/145 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8HB12C GO:0045893 1/145 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8HB12C GO:0045498 1/145 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG8HB12C GO:0005705 1/145 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8HB12C GO:1990248 1/145 regulation of transcription from RNA polymerase II promoter in response to DNA damage biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129] EOG8HB12C GO:0008168 1/145 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8HB12C GO:0008285 1/145 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8HB12C GO:0071390 1/145 cellular response to ecdysone biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] EOG8HB12C GO:0035078 1/145 induction of programmed cell death by ecdysone biological_process "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf] EOG8HB12C GO:0005515 1/145 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8HB12C GO:0005634 1/145 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HB12C GO:0016577 1/145 histone demethylation biological_process "The modification of histones by removal of methyl groups." [GOC:ai] EOG8HB12C GO:0010508 1/145 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8HB12C GO:0001047 1/145 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG8HB12C GO:0071480 1/145 cellular response to gamma radiation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] EOG8HB12C GO:0051568 1/145 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8HB12C GO:0035072 1/145 ecdysone-mediated induction of salivary gland cell autophagic cell death biological_process "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] EOG8W10T4 GO:0020037 1/7 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8W10T4 GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8W10T4 GO:0009055 1/7 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8W10T4 GO:0003677 1/7 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8W10T4 GO:0004003 1/7 ATP-dependent DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] EOG8W10T0 GO:0005509 4/72 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8PVRF4 GO:0007165 2/16 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8PVRF4 GO:0005622 2/16 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8STVKS GO:0000166 21/64 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8STVKS GO:0003676 21/64 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H1D99 GO:0004518 1/250 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8H1D99 GO:0004812 1/250 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8H1D99 GO:0003677 1/250 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG866Z12 GO:0030170 26/95 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG866Z12 GO:0003870 25/95 5-aminolevulinate synthase activity molecular_function "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924] EOG866Z12 GO:0006782 24/95 protoporphyrinogen IX biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] EOG866Z12 GO:0005759 24/95 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG866Z12 GO:0033014 1/95 tetrapyrrole biosynthetic process biological_process "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] EOG866Z12 GO:0009058 1/95 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG866Z12 GO:0040003 1/95 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG866Z12 GO:0003824 1/95 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG866Z17 GO:0016746 22/86 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG866Z17 GO:0004102 3/86 choline O-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824] EOG866Z17 GO:0007268 1/86 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG866Z17 GO:0007399 1/86 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG866Z17 GO:0005829 1/86 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG866Z17 GO:0005634 1/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG866Z17 GO:0008292 1/86 acetylcholine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] EOG866Z17 GO:0007274 1/86 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG86MF2D GO:0046872 25/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86MF2D GO:0000166 25/102 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86MF2D GO:0003723 23/102 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG86MF2D GO:0006397 20/102 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG86MF2D GO:0003729 1/102 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG86MF2D GO:0010628 1/102 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG86MF2D GO:0046833 1/102 positive regulation of RNA export from nucleus biological_process "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] EOG86MF2D GO:1900364 1/102 negative regulation of mRNA polyadenylation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] EOG86MF2D GO:0045879 1/102 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG86MF2D GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J13QK GO:0030246 3/23 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG876NFV GO:0016881 23/88 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG876NFV GO:0004842 3/88 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG876NFV GO:0051299 1/88 centrosome separation biological_process "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] EOG876NFV GO:0051297 1/88 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG876NFV GO:0043518 1/88 negative regulation of DNA damage response, signal transduction by p53 class mediator biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] EOG876NFV GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG876NFV GO:0019904 1/88 protein domain specific binding molecular_function "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] EOG876NFV GO:0007052 1/88 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG876NFV GO:0006281 1/88 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG876NFV GO:1902166 1/88 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] EOG876NFV GO:0002039 1/88 p53 binding molecular_function "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] EOG876NFV GO:0042787 1/88 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG876NFV GO:0005524 1/88 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG876NFV GO:0000422 1/88 mitophagy biological_process "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] EOG876NFV GO:0032436 1/88 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] EOG876NFV GO:0032456 1/88 endocytic recycling biological_process "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] EOG876NFV GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85TG3S GO:0007155 79/281 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG85TG3S GO:0016021 77/281 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85TG3S GO:0005764 5/281 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG85TG3S GO:0004872 5/281 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG85TG3S GO:0035071 2/281 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG85TG3S GO:0048102 2/281 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG85TG3S GO:0005886 1/281 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85TG3S GO:0005887 1/281 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85TG3S GO:0016020 1/281 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG876NFT GO:0003676 52/239 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG876NFT GO:0046872 1/239 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG876NFT GO:0005634 1/239 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG876NFT GO:0003677 1/239 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CJXXJ GO:0004129 3/43 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8CJXXJ GO:0005506 3/43 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8CJXXJ GO:0009060 3/43 aerobic respiration biological_process "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] EOG8CJXXJ GO:0005743 3/43 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8CJXXJ GO:0016021 3/43 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXXJ GO:0006119 3/43 oxidative phosphorylation biological_process "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] EOG8CJXXJ GO:0020037 3/43 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8CJXXJ GO:0070469 3/43 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8CJXXJ GO:0008137 1/43 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8CJXXJ GO:0030431 1/43 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8HQGZR GO:0031419 24/102 cobalamin binding molecular_function "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] EOG8HQGZR GO:0015889 24/102 cobalamin transport biological_process "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8HQGZR GO:0004047 1/102 aminomethyltransferase activity molecular_function "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] EOG8HQGZR GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HQGZR GO:0003700 1/102 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8HQGZR GO:0006546 1/102 glycine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] EOG8HQGZR GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8HQGZR GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HQGZR GO:0005576 1/102 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HQGZR GO:0003677 1/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8KD921 GO:0016021 48/108 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD921 GO:0030054 47/108 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8KD921 GO:0045202 47/108 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8KD921 GO:0005230 47/108 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8KD921 GO:0005886 47/108 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KD921 GO:0006811 2/108 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8KD921 GO:0006909 1/108 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KD921 GO:0016020 1/108 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG876NFJ GO:0005215 2/17 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG876NFJ GO:0016020 1/17 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG876NFJ GO:0016021 1/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KSS1P GO:0004114 19/86 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG8KSS1P GO:0007601 18/86 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8KSS1P GO:0005737 15/86 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8KSS1P GO:0005634 15/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8KSS1P GO:0005515 1/86 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KSS1P GO:0016319 1/86 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8NCPT8 GO:0015018 43/138 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] EOG8NCPT8 GO:0016020 41/138 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NCPT8 GO:0030166 2/138 proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] EOG8NCPT8 GO:0006688 2/138 glycosphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] EOG8NCPT8 GO:0016021 2/138 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NCPT8 GO:0046987 2/138 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity molecular_function "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] EOG8NCPT8 GO:0046872 2/138 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NCPT8 GO:0046988 2/138 asioloorosomucoid beta-1,3-glucuronosyltransferase activity molecular_function "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] EOG8NCPT8 GO:0000139 2/138 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8NCPT8 GO:0009101 2/138 glycoprotein biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] EOG8NCPT8 GO:0046989 2/138 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity molecular_function "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] EOG8NCPT8 GO:0006486 2/138 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8NCPT8 GO:0007422 1/138 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8ZGRS9 GO:0016747 14/63 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8X3KG1 GO:0043565 75/346 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8X3KG1 GO:0008270 75/346 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X3KG1 GO:0003700 74/346 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X3KG1 GO:0005634 6/346 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X3KG1 GO:0006351 4/346 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8X3KG1 GO:0003707 3/346 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8X3KG1 GO:0006366 2/346 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8X3KG1 GO:0000981 2/346 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8X3KG1 GO:0006357 1/346 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8X3KG1 GO:0001103 1/346 RNA polymerase II repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] EOG8X3KG1 GO:0030154 1/346 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8X3KG1 GO:0046982 1/346 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8X3KG1 GO:0005515 1/346 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8X3KG1 GO:0000122 1/346 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8X3KG1 GO:0061320 1/346 pericardial nephrocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] EOG8X3KG1 GO:0060047 1/346 heart contraction biological_process "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] EOG8X3KG1 GO:0007507 1/346 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8X3KG1 GO:0035050 1/346 embryonic heart tube development biological_process "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] EOG8X3KG1 GO:0045944 1/346 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8X3KG1 GO:0001085 1/346 RNA polymerase II transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] EOG8X3KG1 GO:0045893 1/346 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8X3KG1 GO:0009888 1/346 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8X3KG1 GO:0035051 1/346 cardiocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] EOG8X3KG1 GO:0007398 1/346 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8X3KG1 GO:0007389 1/346 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8X3KG1 GO:0007350 1/346 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8X3KG1 GO:0045892 1/346 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8X3KG1 GO:0048542 1/346 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8X3KG1 GO:0022416 1/346 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8X3KG1 GO:0007510 1/346 cardioblast cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8X3KG1 GO:0000983 1/346 transcription factor activity, RNA polymerase II core promoter sequence-specific molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8X3KG1 GO:0008407 1/346 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8X3KG1 GO:0002805 1/346 regulation of antimicrobial peptide biosynthetic process biological_process "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] EOG8X3KG1 GO:0009887 1/346 organ morphogenesis biological_process "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] EOG8X3KG1 GO:0007391 1/346 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8X3KG1 GO:0007179 1/346 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8X3KG1 GO:0042440 1/346 pigment metabolic process biological_process "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] EOG8X3KG1 GO:0008045 1/346 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8X3KG1 GO:0010002 1/346 cardioblast differentiation biological_process "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG89S8S2 GO:0016020 1/2 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG89S8S2 GO:0008324 1/2 cation transmembrane transporter activity molecular_function "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] EOG8VHNR9 GO:0006096 1/3 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8VHNR9 GO:0004807 1/3 triose-phosphate isomerase activity molecular_function "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18588] EOG8VHNR9 GO:0006094 1/3 gluconeogenesis biological_process "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] EOG89GNXP GO:0000387 24/85 spliceosomal snRNP assembly biological_process "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] EOG89GNXP GO:0005681 24/85 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG89GNXP GO:0000245 5/85 spliceosomal complex assembly biological_process "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] EOG89GNXP GO:0034730 1/85 SmD-containing SMN-Sm protein complex cellular_component "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] EOG89GNXP GO:0008344 1/85 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG89GNXP GO:0007629 1/85 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG89GNXP GO:0071254 1/85 cytoplasmic U snRNP body cellular_component "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] EOG89GNXP GO:0034718 1/85 SMN-Gemin2 complex cellular_component "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] EOG89GNXQ GO:0046872 5/43 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89GNXQ GO:0003676 5/43 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZGRST GO:0045454 33/123 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8ZGRST GO:0009055 33/123 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8ZGRST GO:0015035 33/123 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8ZGRST GO:0046872 1/123 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZGRSQ GO:0000049 1/11 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG8ZGRSQ GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZGRSQ GO:0005737 1/11 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZGRSQ GO:0006424 1/11 glutamyl-tRNA aminoacylation biological_process "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8ZGRSQ GO:0004818 1/11 glutamate-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] EOG8KSS18 GO:0005509 2/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NCPTT GO:0003676 13/210 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPTT GO:0003677 8/210 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NCPTT GO:0003964 1/210 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8NCPTT GO:0003723 1/210 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG89GNXZ GO:0016810 2/10 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] EOG89GNXZ GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89GNXZ GO:0016887 2/10 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG89GNXZ GO:0016020 1/10 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG89GNXZ GO:0016021 1/10 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89GNXZ GO:0008565 1/10 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG89GNXZ GO:0009306 1/10 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG89GNXZ GO:0006807 1/10 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG89GNXZ GO:0005215 1/10 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG89GNXZ GO:0005886 1/10 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RFP6Q GO:0004725 24/96 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8RFP6Q GO:0046872 22/96 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RFP6Q GO:0016791 2/96 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8RFP6Q GO:0006470 1/96 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8RFP6Q GO:0008138 1/96 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8RFP6Q GO:0000278 1/96 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8ZGRSF GO:0004402 1/113 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8ZGRSF GO:0042384 1/113 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG8ZGRSF GO:0005509 1/113 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8ZGRSF GO:0031513 1/113 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8ZGRSF GO:0035058 1/113 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG89GNXB GO:0008532 4/91 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] EOG89GNXB GO:0016740 1/91 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG89GNXB GO:0016757 1/91 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8FN70Z GO:0004089 28/206 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8FN70Z GO:0008270 26/206 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FN70Z GO:0005576 26/206 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FN70Z GO:0003964 2/206 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8FN70Z GO:0003723 1/206 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NCPTH GO:0003676 13/22 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPTH GO:0005634 10/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NCPTH GO:0008270 10/22 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NCPTH GO:0046872 3/22 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NCPTF GO:0005634 39/107 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NCPTF GO:0003700 37/107 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NCPTF GO:0043565 34/107 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NCPTF GO:0000976 5/107 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8NCPTF GO:0007601 3/107 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8NCPTF GO:0008407 2/107 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8NCPTF GO:0007479 2/107 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8NCPTF GO:0007455 2/107 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8NCPTF GO:0050896 2/107 response to stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] EOG8NCPTF GO:0001751 2/107 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8NCPTF GO:0008057 2/107 eye pigment granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] EOG8NCPTF GO:0003705 2/107 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8NCPTF GO:0006366 2/107 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8NCPTF GO:0000122 2/107 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NCPTF GO:0008052 2/107 sensory organ boundary specification biological_process "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] EOG8NCPTF GO:0046331 1/107 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8NCPTF GO:0007275 1/107 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8NCPTF GO:0003677 1/107 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NCPTF GO:0045892 1/107 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NCPTF GO:0016055 1/107 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8NCPTF GO:0004000 1/107 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8ZGRSH GO:0005215 1/7 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8ZGRSH GO:0009055 1/7 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8ZGRSH GO:0008289 1/7 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8ZGRSH GO:0030151 1/7 molybdenum ion binding molecular_function "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] EOG8ZGRSH GO:0008658 1/7 penicillin binding molecular_function "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] EOG8ZGRSH GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZGRSH GO:0016491 1/7 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8XD68G GO:0006561 1/3 proline biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] EOG8XD68G GO:0004735 1/3 pyrroline-5-carboxylate reductase activity molecular_function "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] EOG85TG33 GO:0016021 49/151 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85TG33 GO:0006810 39/151 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG85TG33 GO:0006839 10/151 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG85TG33 GO:0031966 10/151 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG85TG33 GO:0005811 1/151 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG85TG33 GO:0005739 1/151 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG870X03 GO:0005783 25/90 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG870X03 GO:0016021 25/90 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG870X03 GO:0005811 1/90 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG870X03 GO:0006621 1/90 protein retention in ER lumen biological_process "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] EOG870X03 GO:0005786 1/90 signal recognition particle, endoplasmic reticulum targeting cellular_component "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] EOG870X03 GO:0005048 1/90 signal sequence binding molecular_function "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] EOG8HQGZ4 GO:0071011 1/99 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8HQGZ4 GO:0071013 1/99 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8HQGZ4 GO:0030529 1/99 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8HQGZ4 GO:0005686 1/99 U2 snRNP cellular_component "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] EOG8HQGZ4 GO:0000398 1/99 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8HQGZ4 GO:0019013 1/99 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8J13Q7 GO:0020037 23/84 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8J13Q7 GO:0005576 2/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8J13Q7 GO:0032440 1/84 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8DRCTV GO:0005507 3/30 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8DRCTV GO:0004129 3/30 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8DRCTV GO:0005743 2/30 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8DRCTV GO:0016021 2/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DRCTV GO:0070469 2/30 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8DRCTV GO:0022900 2/30 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG8DRCTV GO:0016020 1/30 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZKN13 GO:0031532 25/103 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8ZKN13 GO:0004674 23/103 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8ZKN13 GO:0005524 23/103 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZKN13 GO:0035556 21/103 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8ZKN13 GO:0046872 21/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZKN13 GO:0005083 20/103 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8ZKN13 GO:0004697 2/103 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8ZKN13 GO:0030424 1/103 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8ZKN13 GO:0008154 1/103 actin polymerization or depolymerization biological_process "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] EOG8ZKN13 GO:0008039 1/103 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8ZKN13 GO:0006468 1/103 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8ZKN13 GO:0005515 1/103 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8ZKN13 GO:0030426 1/103 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8ZKN13 GO:0032440 1/103 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8ZKN13 GO:0004672 1/103 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8ZKN13 GO:0030833 1/103 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG81ZHQR GO:0004930 2/34 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG81ZHQR GO:0016021 2/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81ZHQR GO:0004715 1/34 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8B0150 GO:0047057 2/89 vitamin-K-epoxide reductase (warfarin-sensitive) activity molecular_function "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN] EOG8BP3TD GO:0046872 25/89 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BP3TD GO:0004462 25/89 lactoylglutathione lyase activity molecular_function "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072] EOG8HQGZ2 GO:0016021 27/144 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HQGZ2 GO:0005783 24/144 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8HQGZ2 GO:0005220 24/144 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor] EOG8HQGZ2 GO:0005262 6/144 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8HQGZ2 GO:0016020 5/144 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HQGZ2 GO:0005524 3/144 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HQGZ2 GO:0006950 3/144 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8HQGZ2 GO:0006457 3/144 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8HQGZ2 GO:0005216 2/144 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8HQGZ2 GO:0048016 1/144 inositol phosphate-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907] EOG8HQGZ2 GO:0042594 1/144 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8HQGZ2 GO:0030536 1/144 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8HQGZ2 GO:0016319 1/144 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8HQGZ2 GO:0000280 1/144 nuclear division biological_process "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] EOG8HQGZ2 GO:0006979 1/144 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8HQGZ2 GO:0030322 1/144 stabilization of membrane potential biological_process "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] EOG8HQGZ2 GO:0007591 1/144 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG8HQGZ2 GO:0005789 1/144 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8HQGZ2 GO:0006874 1/144 cellular calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] EOG8HQGZ2 GO:0055089 1/144 fatty acid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl] EOG8HQGZ2 GO:0007601 1/144 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8HQGZ2 GO:0060259 1/144 regulation of feeding behavior biological_process "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] EOG8HQGZ2 GO:0050909 1/144 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8HQGZ2 GO:0007608 1/144 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8HQGZ2 GO:0007629 1/144 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8HQGZ2 GO:0051209 1/144 release of sequestered calcium ion into cytosol biological_process "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] EOG8XH2FB GO:0046872 27/96 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XH2FB GO:0003676 16/96 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XH2FB GO:0043433 1/96 negative regulation of sequence-specific DNA binding transcription factor activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] EOG8XH2FB GO:0042440 1/96 pigment metabolic process biological_process "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] EOG8XH2FB GO:0008293 1/96 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8XH2FB GO:0007393 1/96 dorsal closure, leading edge cell fate determination biological_process "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] EOG8XH2FB GO:0003677 1/96 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XH2FB GO:0007391 1/96 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8XH2FB GO:0035167 1/96 larval lymph gland hemopoiesis biological_process "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] EOG8XH2FB GO:0006351 1/96 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8XH2FB GO:0009996 1/96 negative regulation of cell fate specification biological_process "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] EOG8XH2FB GO:0046665 1/96 amnioserosa maintenance biological_process "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] EOG8XH2FB GO:0002805 1/96 regulation of antimicrobial peptide biosynthetic process biological_process "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] EOG8XH2FB GO:0001102 1/96 RNA polymerase II activating transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] EOG8XH2FB GO:0007507 1/96 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8XH2FB GO:0007390 1/96 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8XH2FB GO:0042690 1/96 negative regulation of crystal cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] EOG8XH2FB GO:0008134 1/96 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8XH2FB GO:0016021 1/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2FB GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2FB GO:0048542 1/96 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8XH2FB GO:0022416 1/96 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8XH2FB GO:0008258 1/96 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8XH2FB GO:0000122 1/96 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8XH2FB GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XH2FB GO:0007398 1/96 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8XH2FB GO:0048749 1/96 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8XH2FB GO:0007362 1/96 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8XH2FB GO:0030097 1/96 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8XH2FB GO:0006355 1/96 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RBT4B GO:0008270 2/3 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PP0WM GO:0016021 7/140 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PP0WM GO:0004725 1/140 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8PP0WM GO:0016829 1/140 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8XH2H5 GO:0003964 8/565 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8XH2H5 GO:0003723 6/565 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8XH2H5 GO:0022857 1/565 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8XH2H5 GO:0016021 1/565 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD669 GO:0016301 1/65 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8XD669 GO:0016788 1/65 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8XD669 GO:0003676 1/65 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QRKHT GO:0005524 22/59 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QRKHT GO:0016021 22/59 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QRKHT GO:0004672 21/59 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QRKHT GO:0035556 21/59 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8QRKHT GO:0004383 20/59 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG8QRKHT GO:0000226 1/59 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8QRKHT GO:0016849 1/59 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8QRKHT GO:0005525 1/59 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8QRKHT GO:0005815 1/59 microtubule organizing center cellular_component "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] EOG8QRKHT GO:0004872 1/59 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8QRKHT GO:0005887 1/59 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QRKHT GO:0009190 1/59 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8QRKHT GO:0016772 1/59 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8QRKHT GO:0004930 1/59 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8QRKHT GO:0000922 1/59 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8QRKHT GO:0006182 1/59 cGMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] EOG83FKCV GO:0008270 1/9 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83FKCQ GO:0051726 1/96 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG83FKCQ GO:0046982 1/96 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG83FKCQ GO:0043565 1/96 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83FKCQ GO:0006355 1/96 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83FKCQ GO:0003700 1/96 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG83FKCQ GO:0006909 1/96 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG83FKCQ GO:0030308 1/96 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG83FKCQ GO:0048812 1/96 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG83FKCQ GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83FKCQ GO:0000122 1/96 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83FKCQ GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PRW77 GO:0003796 126/416 lysozyme activity molecular_function "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] EOG8PRW77 GO:0016998 121/416 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8PRW77 GO:0016021 20/416 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PRW77 GO:0005886 10/416 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PRW77 GO:0006811 10/416 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8PRW77 GO:0005230 10/416 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PRW77 GO:0019835 9/416 cytolysis biological_process "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] EOG8PRW77 GO:0042742 8/416 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8PRW77 GO:0030054 8/416 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8PRW77 GO:0045202 8/416 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PRW77 GO:0048102 1/416 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8PRW77 GO:0035071 1/416 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8PRW77 GO:0050829 1/416 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8PRW77 GO:0032504 1/416 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8PRW77 GO:0004568 1/416 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8PRW77 GO:0005615 1/416 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8PRW77 GO:0045824 1/416 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8PRW7J GO:0003677 7/55 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8PRW7J GO:0006355 3/55 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8PRW7J GO:0005634 3/55 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PRW7J GO:0000785 3/55 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8PRW7J GO:0004525 1/55 ribonuclease III activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] EOG8PRW7J GO:0006396 1/55 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8PRW7J GO:0003723 1/55 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8PRW7B GO:0008381 4/7 mechanically-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] EOG8PRW7B GO:0016021 4/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD66F GO:0009396 56/195 folic acid-containing compound biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] EOG8XD66F GO:0004488 51/195 methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815] EOG8XD66F GO:0005524 28/195 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XD66F GO:0004329 28/195 formate-tetrahydrofolate ligase activity molecular_function "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] EOG8XD66F GO:0004477 3/195 methenyltetrahydrofolate cyclohydrolase activity molecular_function "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] EOG8XD66F GO:0000287 2/195 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8XD66F GO:0006730 2/195 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8XD66F GO:0004487 2/195 methylenetetrahydrofolate dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22895] EOG8XD66F GO:0046653 1/195 tetrahydrofolate metabolic process biological_process "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732] EOG8XD66F GO:0006164 1/195 purine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8XD66F GO:0009086 1/195 methionine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8XD66F GO:0000105 1/195 histidine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] EOG8XD66F GO:0008652 1/195 cellular amino acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] EOG8XD66F GO:0005739 1/195 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8XD66F GO:0016746 1/195 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8XD66F GO:0035999 1/195 tetrahydrofolate interconversion biological_process "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] EOG8XD66F GO:0005829 1/195 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8XD66F GO:0019509 1/195 L-methionine biosynthetic process from methylthioadenosine biological_process "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361] EOG8XD66F GO:0005737 1/195 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XD66F GO:0042301 1/195 phosphate ion binding molecular_function "Interacting selectively and non-covalently with phosphate." [GOC:jl] EOG8XD66F GO:0005811 1/195 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8XD66F GO:0043874 1/195 acireductone synthase activity molecular_function "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77] EOG8TMTJ1 GO:0005622 3/32 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8TMTJ1 GO:0005525 3/32 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8TMTJ1 GO:0016020 3/32 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TMTJ1 GO:0007264 3/32 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8JQ6CW GO:0015031 72/218 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8JQ6CW GO:0005525 72/218 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8JQ6CW GO:0007264 72/218 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8JQ6CW GO:0004767 4/218 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8JQ6CW GO:0043025 2/218 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8JQ6CW GO:0005515 1/218 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JQ6CW GO:0006897 1/218 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8JQ6CW GO:0045202 1/218 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8CZDW0 GO:0003676 9/35 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CZDW0 GO:0003677 2/35 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83FKC5 GO:0004402 2/11 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8BS02J GO:0003700 1/41 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8BS02J GO:0005634 1/41 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XD66W GO:0016887 1/3 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8XD66W GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BP3T7 GO:0016491 7/22 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8BP3T7 GO:0005506 4/22 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8BP3T7 GO:0010181 4/22 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8BP3T7 GO:0030586 1/22 [methionine synthase] reductase activity molecular_function "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] EOG8BP3T7 GO:0003958 1/22 NADPH-hemoprotein reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] EOG8ZKN1X GO:0006807 72/199 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG8ZKN1X GO:0016811 72/199 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG8ZKN1X GO:0004435 2/199 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8ZKN1X GO:0035556 2/199 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8ZKN1X GO:0006629 2/199 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8ZKN1X GO:0071110 1/199 histone biotinylation biological_process "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] EOG8ZKN1X GO:0019898 1/199 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8ZKN1X GO:0016787 1/199 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZKN1X GO:0009408 1/199 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8ZKN1X GO:0017159 1/199 pantetheine hydrolase activity molecular_function "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448] EOG8ZKN1X GO:0018054 1/199 peptidyl-lysine biotinylation biological_process "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] EOG8H74RC GO:0016021 8/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H74RC GO:0005524 8/36 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H74RC GO:0042626 8/36 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8H74RC GO:0032440 1/36 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8QZB24 GO:0005272 158/406 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8QZB24 GO:0016021 144/406 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QZB24 GO:0016020 15/406 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QZB24 GO:0003964 2/406 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8QZB24 GO:0003723 2/406 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8QZB24 GO:0007638 1/406 mechanosensory behavior biological_process "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] EOG8QZB24 GO:0043022 1/406 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8QZB24 GO:0050975 1/406 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG8QZB24 GO:0050966 1/406 detection of mechanical stimulus involved in sensory perception of pain biological_process "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG8QZB24 GO:0044736 1/406 acid-sensing ion channel activity molecular_function "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl] EOG8QZB24 GO:0030425 1/406 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8QZB24 GO:0048266 1/406 behavioral response to pain biological_process "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] EOG8QZB24 GO:0008345 1/406 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8QZB24 GO:0043025 1/406 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8QZB24 GO:0042256 1/406 mature ribosome assembly biological_process "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] EOG8QZB24 GO:0035725 1/406 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8QZB24 GO:0030424 1/406 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8ZKN1H GO:0033290 25/92 eukaryotic 48S preinitiation complex cellular_component "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] EOG8ZKN1H GO:0003743 25/92 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8ZKN1H GO:0016282 25/92 eukaryotic 43S preinitiation complex cellular_component "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] EOG8ZKN1H GO:0006446 25/92 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8ZKN1H GO:0001731 25/92 formation of translation preinitiation complex biological_process "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] EOG8ZKN1H GO:0005852 25/92 eukaryotic translation initiation factor 3 complex cellular_component "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] EOG8ZKN1H GO:0007052 1/92 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8ZKN1H GO:0000022 1/92 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8ZKN1H GO:0005829 1/92 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8ZKN1H GO:0006413 1/92 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8ZKN1H GO:0019028 1/92 viral capsid cellular_component "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] EOG8BK7KM GO:0004252 2/15 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8WSZR8 GO:0004725 7/16 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8WSZR8 GO:0050254 2/16 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8XPSVV GO:0007018 3/12 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8XPSVV GO:0005930 3/12 axoneme cellular_component "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] EOG8XPSVV GO:0003777 3/12 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8CVJQV GO:0016020 1/24 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CVJQV GO:0005215 1/24 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8JQ6CX GO:0003677 5/35 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86T5F9 GO:0044666 1/113 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG86T5F9 GO:0003682 1/113 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG86T5F9 GO:0048188 1/113 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG86T5F9 GO:0005515 1/113 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86T5F9 GO:0045927 1/113 positive regulation of growth biological_process "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG86T5F9 GO:0045893 1/113 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86T5F9 GO:0043966 1/113 histone H3 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] EOG86T5F9 GO:0007049 1/113 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG86T5F9 GO:0005634 1/113 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86T5F9 GO:0051568 1/113 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG86T5F9 GO:0006338 1/113 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG86T5F9 GO:0043967 1/113 histone H4 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] EOG86T5F9 GO:0000123 1/113 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG86T5F9 GO:0016573 1/113 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG86T5F9 GO:0003713 1/113 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG84BDKG GO:0004930 1/4 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG84BDKG GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QC3PJ GO:0005525 1/9 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG81RSCK GO:0003676 1/2 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8C5G1W GO:0006122 23/67 mitochondrial electron transport, ubiquinol to cytochrome c biological_process "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] EOG8C5G1W GO:0005750 23/67 mitochondrial respiratory chain complex III cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] EOG8C5G1W GO:0007286 1/67 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8C5G1W GO:0008121 1/67 ubiquinol-cytochrome-c reductase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] EOG8V9X6Q GO:0008270 5/13 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FR37J GO:0016021 8/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FR37J GO:0016020 8/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG847J72 GO:0005737 23/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG847J72 GO:0048312 22/97 intracellular distribution of mitochondria biological_process "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] EOG847J72 GO:0003743 3/97 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG847J72 GO:0051646 1/97 mitochondrion localization biological_process "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG847J72 GO:0055059 1/97 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG847J72 GO:0072686 1/97 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8X6FP2 GO:0005615 1/111 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8X6FP2 GO:0035556 1/111 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8X6FP2 GO:0016021 1/111 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X6FP2 GO:0005875 1/111 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8X6FP2 GO:0005787 1/111 signal peptidase complex cellular_component "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] EOG8X6FP2 GO:0008233 1/111 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8X6FP2 GO:0006465 1/111 signal peptide processing biological_process "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] EOG8Q2GVJ GO:0006887 25/89 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8Q2GVJ GO:0000145 25/89 exocyst cellular_component "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] EOG8Q2GVJ GO:0003677 1/89 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Q2GVJ GO:0006313 1/89 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8Q2GVJ GO:0015074 1/89 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8Q2GVJ GO:0004803 1/89 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8616HZ GO:0007155 51/345 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8616HZ GO:0005524 32/345 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616HZ GO:0004672 17/345 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8616HZ GO:0004713 14/345 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8616HZ GO:0004714 7/345 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8616HZ GO:0004715 1/345 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8616HZ GO:0007169 1/345 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8616HZ GO:0006468 1/345 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8616HZ GO:0018108 1/345 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8616HZ GO:0016020 1/345 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8SN432 GO:0042302 1/83 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8577PF GO:0016787 1/6 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG822D00 GO:0016021 8/62 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG822D00 GO:0022891 5/62 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG822D00 GO:0022857 3/62 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG822D00 GO:0008643 2/62 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8FR374 GO:0006233 1/6 dTDP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732] EOG8FR374 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FR374 GO:0004798 1/6 thymidylate kinase activity molecular_function "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] EOG8FR374 GO:0003676 1/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QZB1P GO:0046872 20/78 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QZB1P GO:0003676 20/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QZB1P GO:0005634 4/78 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FR372 GO:0005509 61/185 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8FR372 GO:0007268 2/185 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8FR372 GO:0007269 2/185 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8FR372 GO:0007528 2/185 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8FR372 GO:0046928 2/185 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG8FR372 GO:0016174 2/185 NAD(P)H oxidase activity molecular_function "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1] EOG8FR372 GO:0031284 1/185 positive regulation of guanylate cyclase activity biological_process "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] EOG8FR372 GO:0008021 1/185 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8FR372 GO:0008048 1/185 calcium sensitive guanylate cyclase activator activity molecular_function "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah] EOG8FR372 GO:0016020 1/185 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FR372 GO:0016192 1/185 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG805VGF GO:0008270 17/66 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG85XBBC GO:0003824 4/53 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG84XMWX GO:0038032 24/101 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG84XMWX GO:0004871 23/101 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG84XMWX GO:0005622 22/101 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG84XMWX GO:0007275 22/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG84XMWX GO:0007447 1/101 imaginal disc pattern formation biological_process "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] EOG84XMWX GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84XMWX GO:0005096 1/101 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG84XMWX GO:0007507 1/101 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG84XMWX GO:0035019 1/101 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG84XMWX GO:0007476 1/101 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG84XMWX GO:0007455 1/101 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG84XMWX GO:0019901 1/101 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG84XMWX GO:0043547 1/101 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG84XMWX GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84XMWX GO:0016055 1/101 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG84XMWX GO:0006909 1/101 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84XMWX GO:0005886 1/101 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84XMWX GO:0030178 1/101 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG84XMWX GO:0048477 1/101 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG84XMWX GO:0008013 1/101 beta-catenin binding molecular_function "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] EOG8CVJQ4 GO:0030314 1/110 junctional membrane complex cellular_component "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] EOG8VDSCF GO:0005524 6/40 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VDSCF GO:0017038 6/40 protein import biological_process "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] EOG8VDSCF GO:0016020 6/40 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VDSCF GO:0006605 3/40 protein targeting biological_process "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] EOG8VDSCF GO:0004386 3/40 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VDSCF GO:0003676 2/40 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSCG GO:0016021 18/59 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VDSCG GO:0004930 17/59 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8VDSCG GO:0005886 16/59 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8VDSCG GO:0051966 1/59 regulation of synaptic transmission, glutamatergic biological_process "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] EOG8VDSCG GO:0007216 1/59 G-protein coupled glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] EOG8VDSCG GO:0001641 1/59 group II metabotropic glutamate receptor activity molecular_function "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] EOG8VDSCG GO:0015485 1/59 cholesterol binding molecular_function "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732] EOG8VDSCG GO:0007196 1/59 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] EOG8VDSCG GO:0001642 1/59 group III metabotropic glutamate receptor activity molecular_function "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] EOG8VDSCG GO:0008066 1/59 glutamate receptor activity molecular_function "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] EOG8VDSCG GO:0042734 1/59 presynaptic membrane cellular_component "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194] EOG8VDSCG GO:0016595 1/59 glutamate binding molecular_function "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] EOG8VDSCG GO:0045121 1/59 membrane raft cellular_component "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198] EOG8VDSCG GO:0004965 1/59 G-protein coupled GABA receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] EOG8VDSCG GO:0007528 1/59 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8VDSCG GO:0005887 1/59 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85XBBW GO:0005615 3/136 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG84TRQR GO:0070613 1/82 regulation of protein processing biological_process "Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah] EOG84TRQR GO:0007311 1/82 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG84TRQR GO:0009951 1/82 polarity specification of dorsal/ventral axis biological_process "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] EOG84TRQR GO:0050708 1/82 regulation of protein secretion biological_process "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] EOG84TRQR GO:0005783 1/82 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG84TRQP GO:0000042 23/87 protein targeting to Golgi biological_process "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] EOG84TRQP GO:0042803 1/87 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG84TRQP GO:0017137 1/87 Rab GTPase binding molecular_function "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] EOG84TRQP GO:0005819 1/87 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG84TRQP GO:0007098 1/87 centrosome cycle biological_process "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] EOG84TRQP GO:0000785 1/87 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG84TRQP GO:0030306 1/87 ADP-ribosylation factor binding molecular_function "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732] EOG84TRQP GO:0048193 1/87 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG84TRQP GO:0048471 1/87 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG84TRQP GO:0000138 1/87 Golgi trans cisterna cellular_component "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] EOG84TRQP GO:0016020 1/87 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84TRQP GO:0005737 1/87 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84F8RJ GO:0007165 24/88 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG84F8RJ GO:0005578 24/88 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG84F8RJ GO:0005509 24/88 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG84XMWK GO:0007605 1/101 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG84XMWK GO:0042384 1/101 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG84XMWK GO:0035721 1/101 intraciliary retrograde transport biological_process "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia] EOG84XMWK GO:0035058 1/101 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG84XMWK GO:0031513 1/101 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8GQSKJ GO:0006355 34/134 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GQSKJ GO:0003677 34/134 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GQSKJ GO:0005634 25/134 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GQSKJ GO:0046872 25/134 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GQSKJ GO:0006351 25/134 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GQSKJ GO:0007275 24/134 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8GQSKJ GO:0035288 1/134 anterior head segmentation biological_process "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] EOG8GQSKJ GO:0009608 1/134 response to symbiont biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] EOG8GQSKJ GO:0007389 1/134 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8GQSKJ GO:0007474 1/134 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8GQSKJ GO:0035203 1/134 regulation of lamellocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] EOG8GQSKJ GO:0045087 1/134 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8GQSKJ GO:0042694 1/134 muscle cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] EOG8GQSKJ GO:0035287 1/134 head segmentation biological_process "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837] EOG8GQSKJ GO:0007526 1/134 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8GQSKJ GO:0001700 1/134 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8GQSKJ GO:0007350 1/134 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8GQSKJ GO:0048813 1/134 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8GQSKJ GO:0046427 1/134 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8GQSKJ GO:0035291 1/134 specification of segmental identity, intercalary segment biological_process "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305] EOG8GQSKJ GO:0007476 1/134 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8GQSKJ GO:0035289 1/134 posterior head segmentation biological_process "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] EOG8GQSKJ GO:0016204 1/134 determination of muscle attachment site biological_process "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] EOG8RR8Z8 GO:0006479 19/80 protein methylation biological_process "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] EOG8RR8Z8 GO:0008168 19/80 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8RR8Z8 GO:0005737 4/80 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RR8Z8 GO:0008469 2/80 histone-arginine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [EC:2.1.1.125] EOG8RR8Z8 GO:0008276 2/80 protein methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] EOG8RR8Z8 GO:0019919 1/80 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine biological_process "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] EOG8RR8Z8 GO:0070611 1/80 histone methyltransferase activity (H3-R2 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [EC:2.1.1.125, GOC:mah, PMID:17898714] EOG8RR8Z8 GO:0034970 1/80 histone H3-R2 methylation biological_process "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah] EOG8RR8Z8 GO:0045893 1/80 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RR8Z8 GO:0005829 1/80 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8RR8Z8 GO:0005634 1/80 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RR8Z8 GO:0016277 1/80 [myelin basic protein]-arginine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126] EOG8RR8Z8 GO:0003713 1/80 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8RR8Z8 GO:0035242 1/80 protein-arginine omega-N asymmetric methyltransferase activity molecular_function "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069] EOG8T4G9D GO:0051010 1/39 microtubule plus-end binding molecular_function "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] EOG8T4G9D GO:0007094 1/39 mitotic spindle assembly checkpoint biological_process "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] EOG8T4G9D GO:0008157 1/39 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8T4G9D GO:0030071 1/39 regulation of mitotic metaphase/anaphase transition biological_process "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah] EOG8T4G9D GO:0000776 1/39 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG8T4G9D GO:0005874 1/39 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8T4G9D GO:0034501 1/39 protein localization to kinetochore biological_process "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] EOG8F20H9 GO:0030091 1/8 protein repair biological_process "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] EOG8F20H9 GO:0006979 1/8 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8F20H9 GO:0008113 1/8 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG8F20H9 GO:0008236 1/8 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8F20H9 GO:0033743 1/8 peptide-methionine (R)-S-oxide reductase activity molecular_function "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24167] EOG8RJJHB GO:0006729 23/84 tetrahydrobiopterin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732] EOG8RJJHB GO:0003874 23/84 6-pyruvoyltetrahydropterin synthase activity molecular_function "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051] EOG8RJJHB GO:0046872 5/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RJJHB GO:0006728 1/84 pteridine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] EOG88974P GO:0004653 1/4 polypeptide N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] EOG8F20H3 GO:0016020 37/163 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8F20H3 GO:0007156 2/163 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8F20H3 GO:0001745 2/163 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8F20H3 GO:0005515 2/163 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8F20H3 GO:0007157 2/163 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8F20H3 GO:0007520 2/163 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8F20H3 GO:0061321 1/163 garland nephrocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] EOG8F20H3 GO:0007155 1/163 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8F20H3 GO:0030036 1/163 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8F20H3 GO:0061330 1/163 Malpighian tubule stellate cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8F20H3 GO:0001751 1/163 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8F20H3 GO:0007523 1/163 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG8F20H3 GO:0007220 1/163 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8F20H3 GO:0005917 1/163 nephrocyte diaphragm cellular_component "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] EOG8F20H3 GO:0010950 1/163 positive regulation of endopeptidase activity biological_process "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] EOG8F20H3 GO:0042067 1/163 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG8F20H3 GO:0007286 1/163 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8F20H3 GO:0016324 1/163 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8F20H3 GO:0097206 1/163 nephrocyte filtration biological_process "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] EOG8F20H3 GO:0016202 1/163 regulation of striated muscle tissue development biological_process "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] EOG8F20H3 GO:0036059 1/163 nephrocyte diaphragm assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] EOG8F20H3 GO:0005913 1/163 cell-cell adherens junction cellular_component "An adherens junction which connects a cell to another cell." [GOC:hb] EOG8F20H3 GO:0005886 1/163 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8F20H3 GO:0045747 1/163 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8GQSKS GO:0008270 24/96 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSKS GO:0004176 19/96 ATP-dependent peptidase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] EOG8GQSKT GO:0003676 25/84 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GQSKT GO:0046872 23/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GQSKT GO:0008270 2/84 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSKT GO:0005634 2/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HX7JZ GO:0005737 1/4 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HX7JZ GO:0009253 1/4 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8HX7JZ GO:0004830 1/4 tryptophan-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] EOG8HX7JZ GO:0006436 1/4 tryptophanyl-tRNA aminoacylation biological_process "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8HX7JZ GO:0005975 1/4 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8HX7JZ GO:0016998 1/4 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8HX7JZ GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HX7JZ GO:0003796 1/4 lysozyme activity molecular_function "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] EOG8CJXX9 GO:0003676 2/47 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CG2PV GO:0006355 26/177 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CG2PV GO:0044237 19/177 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8CG2PV GO:0003743 5/177 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8CG2PV GO:0005737 1/177 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CG2PV GO:0071456 1/177 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8CG2PV GO:0005085 1/177 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8CG2PV GO:0005829 1/177 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8CG2PV GO:0000398 1/177 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CG2PV GO:0071013 1/177 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8CG2PV GO:0016853 1/177 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8CG2PV GO:0022008 1/177 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CG2PV GO:0006446 1/177 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8CG2PV GO:0043087 1/177 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8CG2PV GO:0005851 1/177 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG8CG2PV GO:0046523 1/177 S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992] EOG8CG2PV GO:0071011 1/177 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CG2PV GO:0006413 1/177 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8CJXX4 GO:0016788 17/87 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8CJXX4 GO:0006886 17/87 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8CJXX4 GO:0006505 17/87 GPI anchor metabolic process biological_process "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732] EOG8CJXX4 GO:0008340 1/87 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG84QWF9 GO:0016021 1/41 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84QWF9 GO:0005515 1/41 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QFZWD GO:0000184 5/81 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8QFZWD GO:0035145 5/81 exon-exon junction complex cellular_component "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] EOG8QFZWD GO:0005737 5/81 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QFZWD GO:0005515 1/81 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QFZWD GO:0003723 1/81 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG82NMFK GO:0043565 15/62 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82NMFK GO:0005634 15/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TXF65 GO:0016020 1/8 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TXF65 GO:0017038 1/8 protein import biological_process "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] EOG8TXF65 GO:0005215 1/8 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8TXF65 GO:0042597 1/8 periplasmic space cellular_component "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] EOG8TXF69 GO:0005975 35/158 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8TXF69 GO:0004553 35/158 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8TXF69 GO:0005576 3/158 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TXF69 GO:0005215 2/158 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8TXF69 GO:0045088 1/158 regulation of innate immune response biological_process "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8TXF69 GO:0006955 1/158 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8TXF69 GO:0045087 1/158 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8TXF69 GO:0002758 1/158 innate immune response-activating signal transduction biological_process "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8TXF69 GO:0008329 1/158 signaling pattern recognition receptor activity molecular_function "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor] EOG8TXF69 GO:0050830 1/158 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8TXF69 GO:0001872 1/158 (1->3)-beta-D-glucan binding molecular_function "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] EOG8TXF69 GO:0005515 1/158 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TXF69 GO:0030247 1/158 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG8TXF69 GO:0009253 1/158 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8TXF69 GO:0046658 1/158 anchored component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8TXF69 GO:0001530 1/158 lipopolysaccharide binding molecular_function "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] EOG8TXF69 GO:0002221 1/158 pattern recognition receptor signaling pathway biological_process "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] EOG8TXF69 GO:0042834 1/158 peptidoglycan binding molecular_function "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] EOG8P2SHH GO:0017057 21/85 6-phosphogluconolactonase activity molecular_function "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559] EOG8P2SHH GO:0006098 21/85 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG8P2SHH GO:0005975 2/85 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8CG2P0 GO:0008270 24/92 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CG2P0 GO:0018024 24/92 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8CG2P0 GO:0005634 24/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CG2P0 GO:0003682 24/92 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8CG2P0 GO:0003677 18/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CG2P0 GO:0006355 2/92 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CG2P0 GO:0005524 1/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CG2P0 GO:0048477 1/92 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8CG2P0 GO:0042799 1/92 histone methyltransferase activity (H4-K20 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] EOG8CG2P0 GO:0018991 1/92 oviposition biological_process "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] EOG8CG2P0 GO:0051568 1/92 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8CG2P0 GO:0000785 1/92 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8CG2P0 GO:0046974 1/92 histone methyltransferase activity (H3-K9 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] EOG8CG2P0 GO:0001700 1/92 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8CG2P0 GO:0042802 1/92 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8CG2P0 GO:0048096 1/92 chromatin-mediated maintenance of transcription biological_process "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] EOG8CG2P0 GO:0003727 1/92 single-stranded RNA binding molecular_function "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] EOG8CG2P0 GO:0016571 1/92 histone methylation biological_process "The modification of histones by addition of methyl groups." [GOC:ai] EOG8CG2P0 GO:0008641 1/92 small protein activating enzyme activity molecular_function "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] EOG8CG2P0 GO:0051567 1/92 histone H3-K9 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai] EOG8CG2P0 GO:0034770 1/92 histone H4-K20 methylation biological_process "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] EOG8CG2P0 GO:0042800 1/92 histone methyltransferase activity (H3-K4 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] EOG8CG2P0 GO:0035327 1/92 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8CG2P0 GO:0006351 1/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8CG2P0 GO:0042054 1/92 histone methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43] EOG84QWFM GO:0006777 28/114 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG84QWFM GO:0051539 28/114 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG84QWFM GO:0003824 28/114 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG84QWFM GO:0046872 27/114 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84QWFM GO:0019008 24/114 molybdopterin synthase complex cellular_component "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] EOG84QWFM GO:0005525 1/114 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG84QWFM GO:0061597 1/114 cyclic pyranopterin monophosphate synthase activity molecular_function "Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309] EOG8XKXNC GO:0006904 8/47 vesicle docking involved in exocytosis biological_process "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] EOG8CJXXW GO:0005737 1/5 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CJXXW GO:0016149 1/5 translation release factor activity, codon specific molecular_function "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] EOG8CJXXW GO:0005525 1/5 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8CJXXW GO:0003924 1/5 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG82NMF2 GO:0035556 2/13 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG82NMF2 GO:0009190 2/13 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG82NMF2 GO:0016849 2/13 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG82NMF2 GO:0016020 1/13 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82NMF2 GO:0055085 1/13 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG82NMF2 GO:0004871 1/13 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8F4VSG GO:0016491 199/611 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F4VSG GO:0047886 2/611 farnesol dehydrogenase activity molecular_function "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700] EOG8F4VSG GO:0004316 1/611 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8F4VSG GO:0016063 1/611 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8F4VSG GO:0022008 1/611 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8R52GQ GO:0008237 13/75 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8R52GQ GO:0008270 12/75 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R52GQ GO:0004177 3/75 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8TXF6V GO:0008146 20/85 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8TXF6V GO:0016021 20/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TXF6V GO:0016051 20/85 carbohydrate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] EOG8TXF6W GO:0016020 10/48 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TXF6X GO:0003884 20/91 D-amino-acid oxidase activity molecular_function "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] EOG8TXF6X GO:0016641 4/91 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] EOG8TXF6X GO:0008445 3/91 D-aspartate oxidase activity molecular_function "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1] EOG8TXF6X GO:0005777 1/91 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8CJXXG GO:0005201 9/73 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8CJXXG GO:0005581 9/73 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8F4VSJ GO:0005215 1/6 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8F4VSJ GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20HJ GO:0005506 142/475 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8F20HJ GO:0020037 142/475 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8F20HJ GO:0016705 139/475 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8F20HJ GO:0004497 138/475 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8F20HJ GO:0005789 5/475 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8F20HJ GO:0070330 1/475 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8F20HJ GO:0033777 1/475 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG8F20HJ GO:0050591 1/475 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG8F20HJ GO:0033780 1/475 taurochenodeoxycholate 6alpha-hydroxylase activity molecular_function "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] EOG8F20HJ GO:0035220 1/475 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8F20HH GO:0003951 38/113 NAD+ kinase activity molecular_function "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] EOG8F20HH GO:0006741 38/113 NADP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] EOG8F20HH GO:0019674 37/113 NAD metabolic process biological_process "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] EOG8F20HH GO:0048812 1/113 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8RR8ZT GO:0051539 23/91 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8RR8ZT GO:0016020 23/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RR8ZT GO:0016651 21/91 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8RR8ZT GO:0003954 2/91 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8RR8ZT GO:0005739 1/91 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8F20HF GO:0003677 1/114 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X6FPT GO:0005524 26/68 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FPT GO:0004674 24/68 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8X6FPT GO:0004697 2/68 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8X6FPT GO:0004672 1/68 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8X6FPT GO:0005737 1/68 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X6FPT GO:0048680 1/68 positive regulation of axon regeneration biological_process "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] EOG8X6FPT GO:0045886 1/68 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8X6FPT GO:0007623 1/68 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8X6FPT GO:0045793 1/68 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8X6FPT GO:0008360 1/68 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8X6FPT GO:0050773 1/68 regulation of dendrite development biological_process "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] EOG8X6FPT GO:0019915 1/68 lipid storage biological_process "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] EOG8X6FPT GO:0006979 1/68 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8X6FPT GO:0008286 1/68 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG8X6FPT GO:0043066 1/68 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8X6FPT GO:0040014 1/68 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8X6FPT GO:0035556 1/68 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8X6FPT GO:0006915 1/68 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8X6FPT GO:0008361 1/68 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG8X6FPT GO:0005829 1/68 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8X6FPT GO:0035206 1/68 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8X6FPT GO:0007424 1/68 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8X6FPT GO:0031104 1/68 dendrite regeneration biological_process "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] EOG8X6FPT GO:0009986 1/68 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8X6FPT GO:0040018 1/68 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8X6FPT GO:0035091 1/68 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG8X6FPT GO:0046620 1/68 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8X6FPT GO:0006468 1/68 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8X6FPT GO:0042306 1/68 regulation of protein import into nucleus biological_process "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] EOG8X6FPT GO:0005515 1/68 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8X6FPT GO:0030307 1/68 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8X6FPT GO:0008362 1/68 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8X6FPT GO:0060292 1/68 long term synaptic depression biological_process "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] EOG8X6FPT GO:0043025 1/68 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8X6FPT GO:0007427 1/68 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8X6FPT GO:0005886 1/68 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8X6FPT GO:0046622 1/68 positive regulation of organ growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8RR8ZM GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RR8ZM GO:0006829 1/4 zinc II ion transport biological_process "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8RR8ZM GO:0046873 1/4 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8RR8ZM GO:0015684 1/4 ferrous iron transport biological_process "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8T4G96 GO:0006012 27/98 galactose metabolic process biological_process "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] EOG8T4G96 GO:0004335 27/98 galactokinase activity molecular_function "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556] EOG8T4G96 GO:0005524 27/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T4G96 GO:0005737 27/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4G96 GO:0033858 2/98 N-acetylgalactosamine kinase activity molecular_function "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] EOG8W6RB3 GO:0044237 22/91 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8W6RB3 GO:0003743 7/91 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8W6RB3 GO:0006413 1/91 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8W6RB3 GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8W6RB3 GO:0005851 1/91 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG8W6RB3 GO:0030234 1/91 enzyme regulator activity molecular_function "Binds to and modulates the activity of an enzyme." [GOC:mah] EOG8W6RB3 GO:0006446 1/91 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG8W6RB3 GO:0043087 1/91 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8W6RB3 GO:0005829 1/91 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8W6RB3 GO:0050790 1/91 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8W6RB3 GO:0005737 1/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W6RB3 GO:0005085 1/91 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8TQPR7 GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TQPR7 GO:0005452 1/16 inorganic anion exchanger activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] EOG8X3KFB GO:0016021 22/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X3KFB GO:0055085 21/85 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8X3KFB GO:0008028 1/85 monocarboxylic acid transmembrane transporter activity molecular_function "Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] EOG8X3KFB GO:0015718 1/85 monocarboxylic acid transport biological_process "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8FJBTB GO:0004252 1/2 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8HQH1R GO:0016020 1/50 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HQH1R GO:0016192 1/50 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8VHNMG GO:0006904 28/106 vesicle docking involved in exocytosis biological_process "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] EOG8VHNMG GO:0007317 1/106 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8VHNMG GO:0016020 1/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VHNMG GO:0016082 1/106 synaptic vesicle priming biological_process "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] EOG8VHNMG GO:0000281 1/106 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8VHNMG GO:0000149 1/106 SNARE binding molecular_function "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] EOG8VHNMG GO:0032940 1/106 secretion by cell biological_process "The controlled release of a substance by a cell." [GOC:mah] EOG8VHNMG GO:0007268 1/106 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8VHNMG GO:0006887 1/106 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8VHNMG GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VHNMG GO:0015031 1/106 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8VHNMG GO:0005829 1/106 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8VHNMG GO:0043195 1/106 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8VHNMG GO:0016192 1/106 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8VHNMG GO:0019898 1/106 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8VHNMG GO:0009416 1/106 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8VHNMG GO:0048489 1/106 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8VHNMG GO:0007269 1/106 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG80P6QW GO:0005758 27/73 mitochondrial intermembrane space cellular_component "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] EOG80P6QW GO:0016531 27/73 copper chaperone activity molecular_function "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376] EOG80P6QW GO:0006825 27/73 copper ion transport biological_process "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG87WR3Z GO:0004364 77/178 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG87WR3Z GO:0005737 76/178 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87WR3Z GO:0016782 4/178 transferase activity, transferring sulfur-containing groups molecular_function "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG87WR3Z GO:0045174 4/178 glutathione dehydrogenase (ascorbate) activity molecular_function "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427] EOG87WR3Z GO:0006749 4/178 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG87WR3Z GO:0042803 1/178 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG87WR3Z GO:0055114 1/178 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG87WR3Z GO:0045454 1/178 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG87WR3Z GO:0050829 1/178 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG87WR3Z GO:0009055 1/178 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG87WR3Z GO:0006726 1/178 eye pigment biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] EOG87WR3Z GO:0045824 1/178 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG87WR3Z GO:0004734 1/178 pyrimidodiazepine synthase activity molecular_function "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] EOG87WR3Z GO:0006728 1/178 pteridine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] EOG8Z91D4 GO:0006281 1/11 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8Z91D4 GO:0006355 1/11 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Z91D4 GO:0003684 1/11 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8Z91D4 GO:0003887 1/11 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8Z91D4 GO:0016787 1/11 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8GXJ1K GO:0016020 1/24 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GXJ1K GO:0000155 1/24 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8GXJ1K GO:0005524 1/24 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88GZMR GO:0000166 1/8 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG88GZMR GO:0003676 1/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KD91N GO:0004197 14/39 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8KD91N GO:0006915 13/39 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8KD91K GO:0003824 9/64 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KD91K GO:0016301 2/64 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8KD91K GO:0004721 2/64 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8642V3 GO:0005634 11/33 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8642V3 GO:0043565 11/33 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8642V3 GO:0008270 11/33 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8642V3 GO:0003700 11/33 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8642V3 GO:0006351 7/33 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8642V3 GO:0003707 1/33 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8GMXDV GO:0003841 1/5 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] EOG80P6QB GO:0005856 1/66 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG80P6QB GO:0009966 1/66 regulation of signal transduction biological_process "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] EOG80P6QB GO:0008360 1/66 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG80P6QB GO:0005198 1/66 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG80P6QB GO:0005737 1/66 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80P6QB GO:0005886 1/66 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8Q2GW6 GO:0003995 76/231 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8Q2GW6 GO:0050660 74/231 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8Q2GW6 GO:0048813 1/231 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8Q2GW6 GO:0006367 1/231 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8Q2GW6 GO:0005739 1/231 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q2GW6 GO:0001104 1/231 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8Q2GW6 GO:0006357 1/231 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Q2GW6 GO:0016592 1/231 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8Q2GW6 GO:0043958 1/231 acryloyl-CoA reductase activity molecular_function "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] EOG82588M GO:0003824 21/84 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG82588M GO:0046872 2/84 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG87SVWH GO:0003676 1/38 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87SVWH GO:0008270 1/38 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GXJ1R GO:0005509 23/119 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GXJ1R GO:0004871 23/119 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8GXJ1R GO:0004435 23/119 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8GXJ1R GO:0035556 22/119 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8GXJ1R GO:0006629 22/119 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8GXJ1R GO:0046488 1/119 phosphatidylinositol metabolic process biological_process "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732] EOG8GXJ1R GO:0005515 1/119 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GXJ1R GO:0001580 1/119 detection of chemical stimulus involved in sensory perception of bitter taste biological_process "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] EOG8GXJ1R GO:0046673 1/119 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8GXJ1R GO:0009649 1/119 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG8GXJ1R GO:0016028 1/119 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8GXJ1R GO:0007602 1/119 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8GXJ1R GO:0051482 1/119 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway biological_process "Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling] EOG8GXJ1R GO:0045494 1/119 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG8GXJ1R GO:0002385 1/119 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8GXJ1R GO:0006651 1/119 diacylglycerol biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators] EOG8GXJ1R GO:0016042 1/119 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8GXJ1R GO:0006644 1/119 phospholipid metabolic process biological_process "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8GXJ1R GO:0007601 1/119 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8GXJ1R GO:0005096 1/119 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8GXJ1R GO:0019722 1/119 calcium-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] EOG8GXJ1R GO:0008344 1/119 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8GXJ1R GO:0043153 1/119 entrainment of circadian clock by photoperiod biological_process "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] EOG8GXJ1R GO:0008654 1/119 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8GXJ1R GO:0016059 1/119 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG8GXJ1R GO:0043547 1/119 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8GXJ1R GO:0016027 1/119 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG8GXJ1R GO:0004629 1/119 phospholipase C activity molecular_function "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah] EOG8GXJ1R GO:0008377 1/119 light-induced release of internally sequestered calcium ion biological_process "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] EOG8GXJ1R GO:0016056 1/119 rhodopsin mediated signaling pathway biological_process "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] EOG8GXJ1R GO:0043052 1/119 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8GXJ1S GO:0006099 37/105 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8GXJ1S GO:0003994 37/105 aconitate hydratase activity molecular_function "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] EOG8GXJ1S GO:0051539 36/105 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8GXJ1S GO:0032504 1/105 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8GXJ1S GO:0005811 1/105 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8GXJ1S GO:0005615 1/105 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8GXJ1S GO:0005739 1/105 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG825886 GO:0046331 1/87 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8Q87BP GO:0051287 44/136 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8Q87BP GO:0048038 44/136 quinone binding molecular_function "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] EOG8Q87BP GO:0016651 40/136 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8Q87BP GO:0003954 2/136 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8Q87BP GO:0008137 2/136 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8Q87BP GO:0005739 1/136 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q87BP GO:0048812 1/136 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8Q87BP GO:0046331 1/136 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RFP7X GO:0003735 27/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8RFP7X GO:0006412 27/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8RFP7X GO:0005761 26/87 mitochondrial ribosome cellular_component "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] EOG8RFP7X GO:0005762 1/87 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG8642VD GO:0006334 10/35 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8642VD GO:0003677 10/35 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8642VD GO:0000786 10/35 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8642VD GO:0005634 10/35 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Q87BW GO:0008157 1/98 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8642VG GO:0031965 17/58 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG8642VG GO:0055085 17/58 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8642VG GO:0015031 16/58 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8642VG GO:0005643 16/58 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8642VG GO:0051028 16/58 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8642VG GO:0005811 1/58 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8642VG GO:0000166 1/58 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8642VG GO:0007476 1/58 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG87WR31 GO:0008152 1/101 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8Z6538 GO:0004046 96/196 aminoacylase activity molecular_function "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] EOG8Z6538 GO:0006520 96/196 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8Z6538 GO:0005737 96/196 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z6538 GO:0008237 53/196 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8Z6538 GO:0016787 4/196 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8Z6538 GO:0004180 1/196 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG866Z0T GO:0016021 25/105 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z0T GO:0005524 24/105 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG866Z0T GO:0046872 23/105 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG866Z0T GO:0005388 21/105 calcium-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] EOG866Z0T GO:0019829 4/105 cation-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] EOG866Z0T GO:0071421 1/105 manganese ion transmembrane transport biological_process "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG866Z0T GO:0019722 1/105 calcium-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] EOG866Z0T GO:0005794 1/105 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG866Z0T GO:0005783 1/105 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG866Z0T GO:0005777 1/105 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG866Z0T GO:0070588 1/105 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG866Z0T GO:0015410 1/105 manganese-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35] EOG866Z0T GO:0042044 1/105 fluid transport biological_process "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG866Z0T GO:0051208 1/105 sequestering of calcium ion biological_process "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] EOG866Z0T GO:0006816 1/105 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG866Z0V GO:0016021 18/43 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z0V GO:0042052 1/43 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG866Z0V GO:0035996 1/43 rhabdomere microvillus cellular_component "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] EOG8GMXD6 GO:0019028 1/9 viral capsid cellular_component "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] EOG8KD911 GO:0052689 3/275 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8KD911 GO:0007416 2/275 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8KD911 GO:0016020 2/275 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8KD911 GO:0007155 2/275 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8KD911 GO:0004872 2/275 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8KD911 GO:0042043 2/275 neurexin family protein binding molecular_function "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512] EOG8KD911 GO:0005887 2/275 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD911 GO:0045202 2/275 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8KD911 GO:0009986 2/275 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8KD911 GO:0051932 1/275 synaptic transmission, GABAergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030] EOG8KD911 GO:0006909 1/275 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KD911 GO:0003990 1/275 acetylcholinesterase activity molecular_function "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] EOG8KD911 GO:0022008 1/275 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KD911 GO:0030431 1/275 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG83V2BC GO:0043565 2/7 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83V2BC GO:0003676 1/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z91DM GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z91DM GO:0055085 1/8 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8CVJMV GO:0000166 3/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CVJMV GO:0003676 3/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CVJMV GO:0051301 3/103 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8CVJMV GO:0045842 1/103 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8CVJMV GO:0000398 1/103 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CVJMV GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CVJMV GO:0008054 1/103 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8CVJMV GO:0090302 1/103 APC-Cdc20 complex activity molecular_function "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] EOG8CVJMV GO:0009987 1/103 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8CVJMV GO:0005680 1/103 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG8CVJMV GO:0071011 1/103 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CVJMV GO:0000278 1/103 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8CVJMV GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CVJMV GO:0007067 1/103 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8Z652D GO:0000724 14/80 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG8Z652D GO:0003697 13/80 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG8K6JKV GO:0008270 18/83 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K6JKV GO:0007285 1/83 primary spermatocyte growth biological_process "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] EOG8K6JKV GO:0016558 1/83 protein import into peroxisome matrix biological_process "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772] EOG8K6JKV GO:0007031 1/83 peroxisome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] EOG8K6JKV GO:0048137 1/83 spermatocyte division biological_process "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] EOG8K6JKV GO:0007112 1/83 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8K6JKV GO:0007286 1/83 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8K6JKV GO:0005622 1/83 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MD0DW GO:0016021 27/102 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MD0DW GO:0004252 27/102 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8MD0DW GO:0005509 24/102 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TXF7P GO:0003676 1/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V19FD GO:0050661 38/115 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG8V19FD GO:0045454 38/115 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8V19FD GO:0004791 38/115 thioredoxin-disulfide reductase activity molecular_function "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348] EOG8V19FD GO:0050660 38/115 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8V19FD GO:0009055 5/115 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8V19FD GO:0015035 5/115 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8V19FD GO:0004362 4/115 glutathione-disulfide reductase activity molecular_function "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732] EOG8V19FD GO:0005739 2/115 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8V19FD GO:0042803 1/115 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8V19FD GO:0001666 1/115 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8V19FD GO:0005875 1/115 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8V19FD GO:0008340 1/115 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8V19FD GO:0006974 1/115 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8V19FD GO:0022008 1/115 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8V19FD GO:0016209 1/115 antioxidant activity molecular_function "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] EOG8V19FD GO:0005737 1/115 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89S8R3 GO:0009060 1/2 aerobic respiration biological_process "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] EOG89S8R3 GO:0005743 1/2 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG89S8R3 GO:0006119 1/2 oxidative phosphorylation biological_process "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] EOG89S8R3 GO:0016021 1/2 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89S8R3 GO:0004129 1/2 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG89S8R3 GO:0005506 1/2 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG89S8R3 GO:0070469 1/2 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG89S8R3 GO:0020037 1/2 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8K6JKZ GO:0030246 5/23 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG89CSPN GO:0005524 25/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89CSPN GO:0004674 22/92 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG89CSPN GO:0007165 20/92 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG89CSPN GO:0004672 3/92 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG89CSPN GO:0019732 1/92 antifungal humoral response biological_process "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG89CSPN GO:0008063 1/92 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG89CSPN GO:0048262 1/92 determination of dorsal/ventral asymmetry biological_process "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid] EOG89CSPN GO:0035172 1/92 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG89CSPN GO:0019904 1/92 protein domain specific binding molecular_function "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] EOG89CSPN GO:0009620 1/92 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG89CSPN GO:0007352 1/92 zygotic specification of dorsal/ventral axis biological_process "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] EOG89CSPN GO:0005737 1/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89CSPN GO:0030162 1/92 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG89CSPN GO:0045087 1/92 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG89CSPN GO:0030097 1/92 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG89CSPN GO:0006952 1/92 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG89CSPN GO:0005886 1/92 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89CSPN GO:0009950 1/92 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG89CSPN GO:0004709 1/92 MAP kinase kinase kinase activity molecular_function "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] EOG89CSPN GO:0006915 1/92 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG89CSPN GO:0046777 1/92 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG89CSPN GO:0006468 1/92 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG89CSPN GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8K6JKD GO:0046872 30/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8K6JKD GO:0006801 19/95 superoxide metabolic process biological_process "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] EOG8K6JKD GO:0055114 19/95 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8K6JKD GO:0004784 13/95 superoxide dismutase activity molecular_function "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] EOG8K6JKD GO:0030001 10/95 metal ion transport biological_process "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8K6JKD GO:0016532 2/95 superoxide dismutase copper chaperone activity molecular_function "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278] EOG8K6JKD GO:0005777 1/95 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8K6JKD GO:0006979 1/95 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8K6JKD GO:0008340 1/95 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8K6JKD GO:0005737 1/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K6JKD GO:0050821 1/95 protein stabilization biological_process "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] EOG8K6JKD GO:0008270 1/95 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K6JKD GO:0043085 1/95 positive regulation of catalytic activity biological_process "Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb] EOG8K6JKD GO:0019430 1/95 removal of superoxide radicals biological_process "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl] EOG8MD0DB GO:0016020 1/6 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8MD0DB GO:0008137 1/6 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8MD0DB GO:0042773 1/6 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8MD0DB GO:0051536 1/6 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8MD0DB GO:0009055 1/6 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8X3KF4 GO:0006511 20/94 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8X3KF4 GO:0008234 18/94 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8X3KF4 GO:0050821 1/94 protein stabilization biological_process "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] EOG8X3KF4 GO:0016787 1/94 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8X3KF4 GO:0016579 1/94 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG8X3KF4 GO:0042675 1/94 compound eye cone cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] EOG8X3KF4 GO:0031935 1/94 regulation of chromatin silencing biological_process "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] EOG8X3KF4 GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X3KF4 GO:0004843 1/94 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG8X3KF4 GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80VZ4M GO:0005634 26/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80VZ4M GO:0019773 26/91 proteasome core complex, alpha-subunit complex cellular_component "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] EOG80VZ4M GO:0004298 26/91 threonine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG80VZ4M GO:0005737 25/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80VZ4M GO:0006511 25/91 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG80VZ4M GO:0043161 1/91 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] EOG80VZ4M GO:0005839 1/91 proteasome core complex cellular_component "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] EOG80VZ4M GO:0009987 1/91 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8HQH13 GO:0046872 14/52 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MD0DM GO:0015671 1/79 oxygen transport biological_process "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8MD0DM GO:0019825 1/79 oxygen binding molecular_function "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] EOG8MD0DM GO:0005506 1/79 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8MD0DM GO:0020037 1/79 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8J3ZZ3 GO:0007275 6/40 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8J3ZZ3 GO:0016055 6/40 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8J3ZZ3 GO:0005578 6/40 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8FN6Z7 GO:0003676 19/196 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J3ZZ8 GO:0003723 26/75 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8J3ZZ8 GO:0000178 25/75 exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases." [PMID:10465791] EOG8J3ZZ8 GO:0004527 3/75 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8J3ZZ8 GO:0010468 1/75 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8J3ZZ8 GO:0000176 1/75 nuclear exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] EOG8J3ZZ8 GO:0016787 1/75 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8J3ZZ8 GO:0005737 1/75 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XD65V GO:0016021 24/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD65V GO:0004930 24/94 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8XD65V GO:0008188 1/94 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8XD65V GO:0007204 1/94 positive regulation of cytosolic calcium ion concentration biological_process "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] EOG8XD65V GO:0007186 1/94 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8XD65V GO:0001653 1/94 peptide receptor activity molecular_function "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] EOG8XD65V GO:0005887 1/94 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD65V GO:0007218 1/94 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8XD65V GO:0008345 1/94 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8XD65V GO:0002209 1/94 behavioral defense response biological_process "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8XD65V GO:0008344 1/94 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8XD65Q GO:0004177 27/95 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8XD65Q GO:0030145 26/95 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG8XD65Q GO:0008235 10/95 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG8XD65Q GO:0016805 2/95 dipeptidase activity molecular_function "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] EOG85TG29 GO:0006909 1/92 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8P8HZX GO:0003677 2/3 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P8HZX GO:0006357 2/3 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8P8HZX GO:0032784 2/3 regulation of DNA-templated transcription, elongation biological_process "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8P8HZX GO:0003746 1/3 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG876NG6 GO:0005794 4/12 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG876NG6 GO:0006486 4/12 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG876NG6 GO:0016021 4/12 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG876NG6 GO:0008378 3/12 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG876NG6 GO:0047220 1/12 galactosylxylosylprotein 3-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] EOG8P8HZT GO:0016844 38/131 strictosidine synthase activity molecular_function "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016] EOG8P8HZT GO:0009058 37/131 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8P8HZT GO:0005811 1/131 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8P8HZT GO:0009986 1/131 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8P8HZT GO:0004872 1/131 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8P8HZW GO:0055085 1/9 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8P8HZW GO:0009306 1/9 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG8P8HZW GO:0016020 1/9 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DNHN3 GO:0051252 1/5 regulation of RNA metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] EOG8DNHN3 GO:0008428 1/5 ribonuclease inhibitor activity molecular_function "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] EOG8P8HZN GO:0004594 27/128 pantothenate kinase activity molecular_function "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] EOG8P8HZN GO:0005524 27/128 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8P8HZN GO:0015937 27/128 coenzyme A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] EOG8P8HZN GO:0048870 6/128 cell motility biological_process "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] EOG8P8HZN GO:0031514 6/128 motile cilium cellular_component "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8P8HZN GO:0070328 1/128 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8P8HZN GO:0007059 1/128 chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] EOG8P8HZN GO:0045475 1/128 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8P8HZN GO:0006979 1/128 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8P8HZN GO:0005886 1/128 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8P8HZN GO:0048477 1/128 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8P8HZN GO:0071480 1/128 cellular response to gamma radiation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] EOG8P8HZN GO:0040011 1/128 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8P8HZN GO:0005819 1/128 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8P8HZN GO:0016310 1/128 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8P8HZN GO:0007067 1/128 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8P8HZN GO:0007126 1/128 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8P8HZN GO:0007283 1/128 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8P8HZN GO:0005737 1/128 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P8HZN GO:0061024 1/128 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8P8HZN GO:0007476 1/128 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8J13P4 GO:0016887 1/8 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8J13P4 GO:0005524 1/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8J13P4 GO:0008658 1/8 penicillin binding molecular_function "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] EOG870X14 GO:0016705 4/17 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG870X14 GO:0020037 4/17 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG870X14 GO:0005506 4/17 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8SJ7WF GO:0016491 61/186 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8SJ7WF GO:0004303 2/186 estradiol 17-beta-dehydrogenase activity molecular_function "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] EOG8SJ7WF GO:0006909 1/186 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8SJ7WF GO:0005783 1/186 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8SJ7WF GO:0008285 1/186 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8SJ7WF GO:0007030 1/186 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG876NGV GO:0016021 1/25 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SJ7W6 GO:0003676 14/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SJ7W6 GO:0008270 14/99 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SJ7W6 GO:0004504 1/99 peptidylglycine monooxygenase activity molecular_function "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] EOG8SJ7W6 GO:0005507 1/99 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8SJ7W6 GO:0006518 1/99 peptide metabolic process biological_process "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators] EOG8SJ7W6 GO:0016020 1/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8J13PH GO:0006355 1/82 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8J13PH GO:0048188 1/82 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG8J13PH GO:0006351 1/82 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J13PH GO:0046427 1/82 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8J13PH GO:0051568 1/82 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8J13PH GO:0003676 1/82 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J13PH GO:0044666 1/82 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG85TG2Q GO:0003677 22/84 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P8HZ3 GO:0046355 41/115 mannan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732] EOG8P8HZ3 GO:0004567 41/115 beta-mannosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] EOG8P8HZ3 GO:0004553 1/115 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8P8HZ3 GO:0005975 1/115 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG85TG2K GO:0003682 25/95 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG85TG2K GO:0003677 25/95 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85TG2K GO:0005634 25/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85TG2K GO:0007221 1/95 positive regulation of transcription of Notch receptor target biological_process "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] EOG85TG2K GO:0017053 1/95 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG85TG2K GO:0061086 1/95 negative regulation of histone H3-K27 methylation biological_process "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] EOG85TG2K GO:0045892 1/95 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85TG2K GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85TG2K GO:0006351 1/95 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG85TG2K GO:0003714 1/95 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG85TG2K GO:2000619 1/95 negative regulation of histone H4-K16 acetylation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] EOG85TG2K GO:0016568 1/95 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG85TG2K GO:0045747 1/95 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8J13PV GO:0000234 1/15 phosphoethanolamine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] EOG8J13PV GO:0008610 1/15 lipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8J13PV GO:0008168 1/15 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG85TG2C GO:0016887 3/13 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG85TG2C GO:0005524 3/13 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85TG2C GO:0016020 2/13 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85TG2C GO:0015197 2/13 peptide transporter activity molecular_function "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells." [GOC:ai] EOG81VNHV GO:0006309 21/82 apoptotic DNA fragmentation biological_process "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] EOG81VNHV GO:0005737 21/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81VNHV GO:0016787 20/82 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG81VNHV GO:0005634 20/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81VNHV GO:0005622 2/82 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG81VNHV GO:0006915 2/82 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG81VNHV GO:0000790 1/82 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG81VNHV GO:0004536 1/82 deoxyribonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] EOG8BS036 GO:0008233 1/7 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8CVJN2 GO:0005524 25/94 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CVJN2 GO:0004674 21/94 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8CVJN2 GO:0004693 2/94 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8CVJN2 GO:0004672 2/94 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8CVJN2 GO:0006468 1/94 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8CVJN2 GO:0042302 1/94 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8FN6ZB GO:0008270 33/186 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FN6ZB GO:0003700 32/186 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FN6ZB GO:0005634 32/186 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FN6ZB GO:0043565 31/186 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8FN6ZB GO:0016740 2/186 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8FN6ZB GO:0003677 2/186 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FN6ZB GO:0000977 1/186 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG8FN6ZB GO:0035218 1/186 leg disc development biological_process "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] EOG8FN6ZB GO:0007517 1/186 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8FN6ZB GO:0007450 1/186 dorsal/ventral pattern formation, imaginal disc biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] EOG8FN6ZB GO:0007399 1/186 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8FN6ZB GO:0045165 1/186 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG8FN6ZB GO:0007526 1/186 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8FN6ZB GO:0007559 1/186 histolysis biological_process "The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] EOG8FN6ZB GO:0045944 1/186 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8FN6ZB GO:0007476 1/186 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FN6ZB GO:0007479 1/186 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8FN6ZB GO:0048190 1/186 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8FN6ZB GO:0006351 1/186 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8FN6ZB GO:0007411 1/186 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FN6ZB GO:0036011 1/186 imaginal disc-derived leg segmentation biological_process "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] EOG8FN6ZB GO:0007451 1/186 dorsal/ventral lineage restriction, imaginal disc biological_process "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] EOG81K1V8 GO:0005634 1/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81K1V8 GO:0043565 1/22 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG81K1V8 GO:0003700 1/22 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8XD657 GO:0007088 1/40 regulation of mitotic nuclear division biological_process "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8XD657 GO:0007052 1/40 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8XD657 GO:0005875 1/40 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8XD652 GO:0005543 25/106 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8XD652 GO:0003779 1/106 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8XD652 GO:0016020 1/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XD652 GO:0000155 1/106 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8FBM7Z GO:0005634 25/120 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FBM7Z GO:0003700 25/120 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FBM7Z GO:0006260 25/120 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8FBM7Z GO:0006351 22/120 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8FBM7Z GO:0003677 2/120 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FBM7Z GO:0007179 1/120 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8FBM7Z GO:0005667 1/120 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8MKQWQ GO:0003896 30/107 DNA primase activity molecular_function "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] EOG8MKQWQ GO:0051539 1/107 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8MKQWQ GO:0000278 1/107 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8MKQWQ GO:1990077 1/107 primosome complex cellular_component "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207] EOG8MKQWQ GO:0046872 1/107 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MKQWQ GO:0006261 1/107 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG8MKQWQ GO:0001745 1/107 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8MKQWQ GO:0003887 1/107 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8MKQWQ GO:0003677 1/107 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MKQWQ GO:0005658 1/107 alpha DNA polymerase:primase complex cellular_component "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] EOG8MKQWQ GO:0006260 1/107 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8MKQWJ GO:0003676 3/29 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DBWZ4 GO:0009055 2/12 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8DBWZ4 GO:0020037 2/12 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8DBWZ4 GO:0005506 2/12 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8DBWZ4 GO:0016020 1/12 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DBWZ4 GO:0016614 1/12 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8MKQWH GO:0005524 27/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MKQWH GO:0016021 26/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MKQWH GO:0042626 24/95 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8MKQWH GO:0008559 3/95 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG8MKQWH GO:0006879 1/95 cellular iron ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] EOG8MKQWH GO:0055085 1/95 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8MKQWH GO:0005743 1/95 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8FBM7F GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FBM7F GO:0006424 1/7 glutamyl-tRNA aminoacylation biological_process "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8FBM7F GO:0004818 1/7 glutamate-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] EOG8FBM7F GO:0005737 1/7 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85MQK4 GO:0008270 25/108 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG85MQK4 GO:0030163 25/108 protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] EOG85MQK4 GO:0004842 22/108 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG85MQK4 GO:0016874 2/108 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG83FKB0 GO:0000724 31/106 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG83FKB0 GO:0030915 31/106 Smc5-Smc6 complex cellular_component "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] EOG83FKB0 GO:0051276 4/106 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG83FKB0 GO:0005524 4/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83FKB0 GO:0006974 1/106 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG83FKB0 GO:0033743 1/106 peptide-methionine (R)-S-oxide reductase activity molecular_function "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24167] EOG83FKB0 GO:0031000 1/106 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG85HVDN GO:0070403 1/3 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG85HVDN GO:0003857 1/3 3-hydroxyacyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] EOG85HVDN GO:0006631 1/3 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG81ZHR5 GO:0016772 1/8 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG81ZHR5 GO:0006744 1/8 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG84TRPH GO:0005975 41/141 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG84TRPH GO:0016757 39/141 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG84TRPH GO:0008344 1/141 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG84TRPH GO:0033842 1/141 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] EOG84TRPH GO:0005794 1/141 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG84TRPH GO:0007528 1/141 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG84TRPH GO:0009247 1/141 glycolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] EOG84TRPH GO:0003945 1/141 N-acetyllactosamine synthase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] EOG84TRPH GO:0008376 1/141 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG84TRPH GO:0006044 1/141 N-acetylglucosamine metabolic process biological_process "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] EOG8VX4MS GO:0003677 36/109 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4MS GO:0007469 6/109 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG8VX4MS GO:0007379 6/109 segment specification biological_process "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8VX4MS GO:0003700 6/109 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8VX4MS GO:0005634 6/109 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VX4MS GO:0006351 6/109 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8VX4MS GO:0006355 6/109 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8VX4MS GO:0048749 6/109 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8VX4MS GO:0005515 2/109 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8VX4MS GO:0021556 2/109 central nervous system formation biological_process "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] EOG8B2WBZ GO:0006487 24/82 protein N-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] EOG8B2WBZ GO:0016020 24/82 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8B2WBZ GO:0003830 24/82 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] EOG86X1RX GO:0042981 1/29 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG86X1RX GO:0005622 1/29 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8QZB36 GO:0030246 4/21 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG834ZNH GO:0016020 9/16 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG834ZNH GO:0015321 9/16 sodium-dependent phosphate transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] EOG834ZNH GO:0044237 1/16 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG834ZNH GO:0003824 1/16 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG834ZNH GO:0050662 1/16 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG84F8QM GO:0005975 94/390 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG84F8QM GO:0004553 93/390 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG84F8QM GO:0008422 1/390 beta-glucosidase activity molecular_function "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] EOG84F8QM GO:0008970 1/390 phosphatidylcholine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] EOG84F8QM GO:0052740 1/390 1-acyl-2-lysophosphatidylserine acylhydrolase activity molecular_function "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] EOG84F8QM GO:0052739 1/390 phosphatidylserine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034] EOG84F8Q2 GO:0004871 24/96 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG84F8Q2 GO:0006355 22/96 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84F8Q2 GO:0005634 21/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84F8Q2 GO:0003677 21/96 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84F8Q2 GO:0006351 20/96 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG84F8Q2 GO:0003989 2/96 acetyl-CoA carboxylase activity molecular_function "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] EOG84F8Q2 GO:0006366 1/96 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG84F8Q2 GO:0046982 1/96 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG84F8Q2 GO:0048800 1/96 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG84F8Q2 GO:0000122 1/96 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG84F8Q2 GO:0036011 1/96 imaginal disc-derived leg segmentation biological_process "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] EOG84F8Q2 GO:0048814 1/96 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG84F8Q2 GO:0010092 1/96 specification of organ identity biological_process "The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] EOG84F8Q2 GO:0007469 1/96 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG84F8Q2 GO:0045676 1/96 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG80ZTCQ GO:0003678 1/149 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG80ZTCQ GO:0000723 1/149 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG80ZTCQ GO:0006281 1/149 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG80ZTCQ GO:0003676 1/149 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80ZTCQ GO:0003723 1/149 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG80ZTCQ GO:0003964 1/149 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG84F8Q5 GO:0005089 19/85 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG84F8Q5 GO:0035556 1/85 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG84F8Q5 GO:0007480 1/85 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG85XBC1 GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85XBC1 GO:0004659 1/4 prenyltransferase activity molecular_function "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] EOG85XBC1 GO:0006744 1/4 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8JMB3Q GO:0004842 14/67 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8JMB3Q GO:0008270 14/67 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8JMB3R GO:0005886 1/39 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8JMB3R GO:0016021 1/39 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JMB3R GO:0004930 1/39 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8S4RX8 GO:0003735 1/10 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8S4RX8 GO:0005840 1/10 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8S4RX8 GO:0006412 1/10 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG84TRP1 GO:0016538 20/96 cyclin-dependent protein serine/threonine kinase regulator activity molecular_function "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] EOG84TRP1 GO:0051302 20/96 regulation of cell division biological_process "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] EOG84TRP1 GO:0051726 20/96 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG84TRP1 GO:0016740 2/96 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG84TRP1 GO:0044719 1/96 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG84TRP1 GO:0006909 1/96 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84TRP2 GO:0031227 26/90 intrinsic component of endoplasmic reticulum membrane cellular_component "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] EOG84TRP2 GO:0006024 26/90 glycosaminoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] EOG84TRP2 GO:0016021 26/90 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84TRP2 GO:0015012 26/90 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG84TRP2 GO:0016758 23/90 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG84TRP2 GO:0050508 3/90 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] EOG84TRP2 GO:0015014 1/90 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] EOG84TRP2 GO:0015020 1/90 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG84TRP2 GO:0000139 1/90 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG84TRP2 GO:0008375 1/90 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG84TRP2 GO:0030206 1/90 chondroitin sulfate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] EOG84TRP2 GO:0050509 1/90 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity molecular_function "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] EOG84TRP2 GO:0016055 1/90 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG84TRP2 GO:0005783 1/90 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG84TRP2 GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84TRP2 GO:0007275 1/90 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG84TRP2 GO:0006044 1/90 N-acetylglucosamine metabolic process biological_process "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] EOG84TRP2 GO:0006486 1/90 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG84TRP2 GO:0030210 1/90 heparin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] EOG84TRP2 GO:0005794 1/90 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG84TRP2 GO:0008101 1/90 decapentaplegic signaling pathway biological_process "A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827] EOG84TRP2 GO:0007224 1/90 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG86X1R7 GO:0004518 13/37 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG86X1R7 GO:0003677 13/37 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86X1R7 GO:0008270 7/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG85MQKK GO:0016021 18/54 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85MQKK GO:0005272 18/54 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG85MQKM GO:0005576 18/84 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85MQKM GO:0006629 18/84 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG85MQKM GO:0016787 16/84 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG85MQKM GO:0003824 2/84 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8MKQW8 GO:0016620 2/9 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG85MQKC GO:0005247 35/124 voltage-gated chloride channel activity molecular_function "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG85MQKC GO:0030554 29/124 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG85MQKC GO:0016021 28/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85MQKC GO:0016020 6/124 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85MQKC GO:0006821 1/124 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG85MQKC GO:0034707 1/124 chloride channel complex cellular_component "An ion channel complex through which chloride ions pass." [GOC:mah] EOG85MQKC GO:0015629 1/124 actin cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] EOG8FBM72 GO:0004930 20/109 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FBM72 GO:0016020 20/109 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FBM72 GO:0007218 2/109 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8QRKKJ GO:0016021 19/53 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QRKKJ GO:0046331 1/53 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8QRKKJ GO:0030097 1/53 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8QRKKJ GO:0005802 1/53 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG8QRKKJ GO:0048471 1/53 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG834ZPQ GO:0005634 23/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG834ZPQ GO:0008270 23/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG834ZPQ GO:0003676 2/86 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z38V7 GO:0005874 21/70 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8Z38V7 GO:0000226 21/70 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8Z38V7 GO:0005875 1/70 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8Z38V7 GO:0008017 1/70 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8Z38V7 GO:0007017 1/70 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8Z38V1 GO:0008039 1/38 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG84XMZQ GO:0005549 69/258 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NGK1D GO:0008270 118/444 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NGK1D GO:0008237 118/444 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8NGK1D GO:0004177 19/444 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8NGK1D GO:0033227 1/444 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8NGK1D GO:0004463 1/444 leukotriene-A4 hydrolase activity molecular_function "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327] EOG8NGK1D GO:0006508 1/444 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8NGK1G GO:0004725 25/171 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8NGK1G GO:0050254 2/171 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8NGK1G GO:0001700 1/171 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8NGK1G GO:0005001 1/171 transmembrane receptor protein tyrosine phosphatase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8NGK1G GO:0008201 1/171 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8NGK1G GO:0048675 1/171 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8NGK1G GO:0005925 1/171 focal adhesion cellular_component "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] EOG8NGK1G GO:0005515 1/171 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NGK1G GO:0005875 1/171 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NGK1G GO:0016021 1/171 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NGK1G GO:0007412 1/171 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8NGK1G GO:0048841 1/171 regulation of axon extension involved in axon guidance biological_process "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] EOG8NGK1G GO:0007399 1/171 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8NGK1G GO:0035335 1/171 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8NGK1G GO:0030424 1/171 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8NGK1G GO:0032093 1/171 SAM domain binding molecular_function "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] EOG8NGK1G GO:0005886 1/171 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NGK1G GO:0048477 1/171 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8NGK1G GO:0007155 1/171 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8NGK1G GO:0008045 1/171 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8NGK1G GO:0045467 1/171 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8NGK1G GO:0007411 1/171 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8NGK1G GO:0051124 1/171 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8NGK1G GO:0008594 1/171 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8NGK1G GO:0008360 1/171 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8NGK1G GO:0016162 1/171 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG8NGK1G GO:0031290 1/171 retinal ganglion cell axon guidance biological_process "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] EOG8NGK1G GO:0006470 1/171 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8QJV2M GO:0046331 1/92 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8JQ6D9 GO:0019464 27/87 glycine decarboxylation via glycine cleavage system biological_process "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] EOG8JQ6D9 GO:0005960 27/87 glycine cleavage complex cellular_component "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] EOG8JQ6D9 GO:0005739 1/87 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8JQ6D9 GO:0035220 1/87 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8TXF5S GO:0007229 1/28 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8TXF5S GO:0007155 1/28 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8TXF5S GO:0016021 1/28 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV2W GO:0008484 1/9 sulfuric ester hydrolase activity molecular_function "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] EOG8QJV2V GO:0008146 160/572 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QJV2V GO:0004027 62/572 alcohol sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] EOG8QJV2V GO:0004304 10/572 estrone sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] EOG8QJV2V GO:0005829 3/572 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QJV2V GO:0051923 3/572 sulfation biological_process "The addition of a sulfate group to a molecule." [http://www.onelook.com] EOG8QJV2V GO:0006805 2/572 xenobiotic metabolic process biological_process "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] EOG8QJV2V GO:0004062 1/572 aryl sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] EOG8QJV2Z GO:0007606 16/1207 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0005515 9/1207 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QJV2Z GO:0016021 3/1207 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV2Z GO:0008039 1/1207 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8QJV2Z GO:0050914 1/1207 sensory perception of salty taste biological_process "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0002115 1/1207 store-operated calcium entry biological_process "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] EOG8QJV2Z GO:0035199 1/1207 salt aversion biological_process "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] EOG8QJV2Z GO:0048149 1/1207 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8QJV2Z GO:0005886 1/1207 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XPSW6 GO:0008270 224/674 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XPSW6 GO:0004222 224/674 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8XPSW6 GO:0006909 1/674 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8XPSW6 GO:0016020 1/674 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XPSW6 GO:0004175 1/674 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8XPSW6 GO:0032504 1/674 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8XPSW6 GO:0006508 1/674 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8XPSW6 GO:0046331 1/674 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XPSW6 GO:0005615 1/674 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8XPSW6 GO:0022008 1/674 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82FVXD GO:0003723 1/84 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG82FVXD GO:0004721 1/84 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG82FVXD GO:0009982 1/84 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG82FVXD GO:0016021 1/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82FVXD GO:0006396 1/84 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG82FVXD GO:0005509 1/84 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG82FVXD GO:0001522 1/84 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG82JR9Q GO:0005524 1/2 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82JR9Q GO:0005871 1/2 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG82JR9Q GO:0007018 1/2 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG82JR9Q GO:0003777 1/2 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8F4VRM GO:0005524 26/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F4VRM GO:0004672 21/101 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8F4VRM GO:0004674 2/101 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8F4VRM GO:0004709 2/101 MAP kinase kinase kinase activity molecular_function "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] EOG8F4VRM GO:0004702 1/101 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8F4VRM GO:0035220 1/101 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8F4VRM GO:0023014 1/101 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8F4VRM GO:0008366 1/101 axon ensheathment biological_process "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] EOG8F4VRM GO:0006468 1/101 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8F4VRM GO:0008065 1/101 establishment of blood-nerve barrier biological_process "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] EOG8F4VRM GO:0008362 1/101 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8F4VRM GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82FVXB GO:0005615 7/105 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG82FVXB GO:0010506 7/105 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG82FVXB GO:0003700 1/105 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82FVXB GO:0043565 1/105 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8F20KH GO:0046331 1/71 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8QNQD0 GO:0003677 21/117 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QNQD0 GO:0003676 2/117 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QNQD0 GO:0003964 1/117 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8QNQD0 GO:0003723 1/117 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG84BDJ9 GO:0005840 5/80 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG84BDJ9 GO:0030529 2/80 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG84BDJ9 GO:0005762 2/80 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG84BDJ9 GO:0006412 2/80 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG84BDJ9 GO:0003735 2/80 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG82FVXT GO:0004345 26/101 glucose-6-phosphate dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] EOG82FVXT GO:0050661 26/101 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG82FVXT GO:0006098 26/101 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG82FVXT GO:0051156 3/101 glucose 6-phosphate metabolic process biological_process "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] EOG82FVXT GO:0006739 3/101 NADP metabolic process biological_process "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] EOG82FVXV GO:0006950 1/16 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG82FVXV GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82FVXV GO:0055085 1/16 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8F20KW GO:0009055 2/7 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8F20KW GO:0045454 2/7 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8F20KW GO:0015035 2/7 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG8F20KW GO:0015031 1/7 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8F20KW GO:0051262 1/7 protein tetramerization biological_process "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] EOG8GJ23P GO:0030723 1/143 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8GJ23P GO:0004518 1/143 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8GJ23P GO:0030727 1/143 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG8GJ23P GO:0030717 1/143 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8GJ23P GO:0048471 1/143 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8GJ23P GO:0005737 1/143 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GJ23P GO:0030719 1/143 P granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] EOG8GJ23P GO:0046872 1/143 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GJ23P GO:0005634 1/143 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GJ23P GO:0030422 1/143 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG8GJ23P GO:0048477 1/143 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8GJ23P GO:0034587 1/143 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG8GJ23P GO:0000166 1/143 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8GJ23P GO:0003723 1/143 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GJ23P GO:0009953 1/143 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8GJ23P GO:0005694 1/143 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG82FVXZ GO:0007279 1/76 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG82FVXZ GO:0016480 1/76 negative regulation of transcription from RNA polymerase III promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] EOG82FVXZ GO:0005938 1/76 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG82FVXZ GO:0005643 1/76 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG82FVXZ GO:0007278 1/76 pole cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG82FVXZ GO:0007315 1/76 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG82FVXZ GO:0034399 1/76 nuclear periphery cellular_component "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] EOG82FVXZ GO:0005634 1/76 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82FVXZ GO:0045892 1/76 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NCPV2 GO:0005779 30/89 integral component of peroxisomal membrane cellular_component "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] EOG8NCPV2 GO:0016559 30/89 peroxisome fission biological_process "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] EOG8NCPV2 GO:0046331 1/89 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG808QNS GO:0016620 1/117 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8GMX9R GO:0004930 18/64 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8GMX9R GO:0016021 17/64 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GMX9R GO:0005886 14/64 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8GMX9R GO:0016020 2/64 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GMX9R GO:0007166 1/64 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8GMX9R GO:0007218 1/64 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8GMX9R GO:0004888 1/64 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8KWN7B GO:0005856 1/93 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8KWN7B GO:0005737 1/93 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8KWN7B GO:0035320 1/93 imaginal disc-derived wing hair site selection biological_process "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] EOG8KWN7B GO:0005929 1/93 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8KWN7B GO:0005886 1/93 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8GJ232 GO:0006357 24/106 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GJ232 GO:0032784 24/106 regulation of DNA-templated transcription, elongation biological_process "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8GJ232 GO:0005634 22/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GJ232 GO:0006351 22/106 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GJ232 GO:0003746 2/106 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8GJ232 GO:0000122 1/106 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GJ232 GO:0032785 1/106 negative regulation of DNA-templated transcription, elongation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8GJ232 GO:0007549 1/106 dosage compensation biological_process "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] EOG8GJ232 GO:0016746 1/106 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8GJ232 GO:0046982 1/106 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8GJ232 GO:0007095 1/106 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8GJ232 GO:0006368 1/106 transcription elongation from RNA polymerase II promoter biological_process "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] EOG8GJ232 GO:0032786 1/106 positive regulation of DNA-templated transcription, elongation biological_process "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] EOG8GJ232 GO:0007052 1/106 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8GJ232 GO:0032044 1/106 DSIF complex cellular_component "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865] EOG8GJ232 GO:0008023 1/106 transcription elongation factor complex cellular_component "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] EOG8GJ232 GO:0005700 1/106 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8GJ232 GO:0045944 1/106 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GJ232 GO:0005705 1/106 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8GJ232 GO:0005703 1/106 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG84XMZ1 GO:0006098 5/37 pentose-phosphate shunt biological_process "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] EOG84XMZ1 GO:0004616 5/37 phosphogluconate dehydrogenase (decarboxylating) activity molecular_function "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] EOG84XMZ1 GO:0008442 2/37 3-hydroxyisobutyrate dehydrogenase activity molecular_function "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] EOG84XMZ1 GO:0006573 2/37 valine metabolic process biological_process "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] EOG84XMZ2 GO:0004602 43/144 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG84XMZ2 GO:0006979 43/144 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG84XMZ2 GO:0005794 1/144 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG84XMZ2 GO:0005615 1/144 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG84XMZ2 GO:0047066 1/144 phospholipid-hydroperoxide glutathione peroxidase activity molecular_function "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] EOG84XMZ2 GO:0032504 1/144 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG84XMZ2 GO:0004601 1/144 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8Z38VZ GO:0032440 1/82 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG83N9TS GO:0016021 1/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83N9TS GO:0017080 1/63 sodium channel regulator activity molecular_function "Modulates the activity of a sodium channel." [GOC:mah] EOG83N9TS GO:0002028 1/63 regulation of sodium ion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] EOG8Z38VB GO:0016020 41/234 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z38VB GO:0008654 41/234 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8Z38VB GO:0003841 41/234 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] EOG8Z38VB GO:0016746 6/234 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Z38VB GO:0048149 1/234 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8QJV27 GO:0016787 6/51 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XWJBJ GO:0005198 1/34 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8STVJH GO:0016021 8/57 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8STVJH GO:0016491 8/57 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8STVJH GO:0005506 8/57 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8STVJH GO:0006633 8/57 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8STVJK GO:0005634 36/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVJK GO:0003677 34/106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVJK GO:0008270 34/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8STVJK GO:0018024 34/106 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8STVJK GO:0005694 30/106 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8STVJK GO:0008168 2/106 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8STVJK GO:0051038 2/106 negative regulation of transcription during meiosis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai] EOG8STVJK GO:0006351 2/106 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8STVJK GO:0048477 2/106 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8STVJK GO:0035220 1/106 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8STVJK GO:0060968 1/106 regulation of gene silencing biological_process "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] EOG8STVJK GO:0051567 1/106 histone H3-K9 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai] EOG8STVJK GO:0007275 1/106 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8STVJK GO:0040029 1/106 regulation of gene expression, epigenetic biological_process "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] EOG8STVJK GO:0044026 1/106 DNA hypermethylation biological_process "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/] EOG8STVJK GO:0005700 1/106 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8STVJK GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8STVJK GO:0045814 1/106 negative regulation of gene expression, epigenetic biological_process "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators] EOG8STVJK GO:0010385 1/106 double-stranded methylated DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155] EOG8STVJK GO:0048132 1/106 female germ-line stem cell asymmetric division biological_process "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] EOG8STVJK GO:0002165 1/106 instar larval or pupal development biological_process "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8STVJK GO:0005515 1/106 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8STVJK GO:0045892 1/106 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVJK GO:0046974 1/106 histone methyltransferase activity (H3-K9 specific) molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] EOG82NMG4 GO:0006412 26/112 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG82NMG4 GO:0003735 26/112 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG82NMG4 GO:0015935 25/112 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG82NMG4 GO:0005783 7/112 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG82NMG4 GO:0005840 2/112 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG82NMG4 GO:0051298 1/112 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG82NMG4 GO:0051297 1/112 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG82VBZ1 GO:0003964 6/161 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG82VBZ1 GO:0003676 6/161 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82VBZ1 GO:0003723 6/161 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG82VBZ1 GO:0008270 4/161 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82VBZ1 GO:0015074 3/161 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG82VBZ1 GO:0004190 2/161 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8Z653W GO:0015935 1/13 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG8Z653W GO:0006412 1/13 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8Z653W GO:0019843 1/13 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8Z653W GO:0003735 1/13 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG82NMG1 GO:0005549 18/64 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG82NMG1 GO:0005550 1/64 pheromone binding molecular_function "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] EOG82NMG1 GO:0007606 1/64 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG82NMG1 GO:0005576 1/64 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z653J GO:0005576 30/178 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z653J GO:0008270 1/178 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z653J GO:0004222 1/178 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8Z653J GO:0031012 1/178 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8PG8FH GO:0004252 1/19 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8STVJS GO:0005524 25/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8STVJS GO:0016021 22/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8STVJS GO:0042626 22/91 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8STVJS GO:0016887 2/91 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8STVJS GO:0016020 2/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8STVJS GO:0008559 1/91 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG8STVJS GO:0006810 1/91 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8QFZTV GO:0003824 25/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QFZTV GO:0005509 25/119 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8QFZTV GO:0008936 3/119 nicotinamidase activity molecular_function "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] EOG8QFZTV GO:0003735 1/119 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8QFZTV GO:0043524 1/119 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8QFZTV GO:0008340 1/119 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8QFZTV GO:0005840 1/119 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8QFZTV GO:0006979 1/119 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8QFZTV GO:0006412 1/119 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG80S2X7 GO:0003677 4/29 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80S2X7 GO:0004518 4/29 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG80S2X7 GO:0008270 2/29 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H48HP GO:0016020 2/34 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81RSBD GO:0005759 2/6 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG81RSBD GO:0000774 2/6 adenyl-nucleotide exchange factor activity molecular_function "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] EOG81RSBD GO:0006457 2/6 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG81RSBD GO:0016853 1/6 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8H48HH GO:0009235 4/153 cobalamin metabolic process biological_process "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] EOG8H48HH GO:0005739 4/153 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8H48HH GO:0048488 1/153 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8H48HH GO:0030036 1/153 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG89CSQT GO:0003677 1/129 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89CSQT GO:0006726 1/129 eye pigment biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] EOG89CSQT GO:0008270 1/129 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8W6RC8 GO:0036355 1/5 2-iminoacetate synthase activity molecular_function "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671] EOG8G7FCB GO:0016021 42/190 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FCB GO:0008271 30/190 secondary active sulfate transmembrane transporter activity molecular_function "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] EOG8G7FCB GO:0015116 13/190 sulfate transmembrane transporter activity molecular_function "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] EOG8G7FCB GO:0005452 1/190 inorganic anion exchanger activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] EOG8G7FCB GO:1902358 1/190 sulfate transmembrane transport biological_process "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] EOG8G7FCB GO:0015106 1/190 bicarbonate transmembrane transporter activity molecular_function "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] EOG8G7FCB GO:0008272 1/190 sulfate transport biological_process "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8G7FCB GO:0019532 1/190 oxalate transport biological_process "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] EOG8G7FCB GO:0015724 1/190 formate transport biological_process "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8G7FCB GO:0015085 1/190 calcium ion transmembrane transporter activity molecular_function "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] EOG8G7FCB GO:0070588 1/190 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8G7FCB GO:0015499 1/190 formate transmembrane transporter activity molecular_function "Enables the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] EOG8G7FCB GO:0019531 1/190 oxalate transmembrane transporter activity molecular_function "Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] EOG8G7FCB GO:0015701 1/190 bicarbonate transport biological_process "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80VZ73 GO:0020037 1/2 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG80VZ73 GO:0006979 1/2 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG80VZ73 GO:0004601 1/2 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8W6RCC GO:0003700 2/16 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8W6RCC GO:0003677 2/16 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81C99Z GO:0019867 23/93 outer membrane cellular_component "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] EOG81C99Z GO:0005741 1/93 mitochondrial outer membrane cellular_component "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] EOG81C99Z GO:0016021 1/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG869T8R GO:0016998 1/9 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG841STT GO:0006030 2/8 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG841STT GO:0005576 2/8 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG841STT GO:0008061 2/8 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8BK7K6 GO:0019354 2/8 siroheme biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] EOG8BK7K6 GO:0043115 2/8 precorrin-2 dehydrogenase activity molecular_function "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616] EOG8BK7K6 GO:0008168 1/8 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8BK7K6 GO:0004851 1/8 uroporphyrin-III C-methyltransferase activity molecular_function "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] EOG8BK7K6 GO:0051287 1/8 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8BK7K6 GO:0051266 1/8 sirohydrochlorin ferrochelatase activity molecular_function "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [EC:4.99.1.4, RHEA:24363] EOG8BK7K6 GO:0009236 1/8 cobalamin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732] EOG8W10V0 GO:0005975 167/551 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8W10V0 GO:0006032 166/551 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8W10V0 GO:0004568 166/551 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8W10V0 GO:0008061 105/551 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8W10V0 GO:0005576 104/551 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8W10V0 GO:0006030 4/551 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8W10V0 GO:0016021 3/551 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W10V0 GO:0004553 3/551 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8W10V0 GO:0005615 2/551 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8W10V0 GO:0000272 2/551 polysaccharide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] EOG8BK7K2 GO:0048515 2/38 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG89CSQ4 GO:0042052 1/112 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG89CSQ4 GO:0032414 1/112 positive regulation of ion transmembrane transporter activity biological_process "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] EOG89CSQ4 GO:0046716 1/112 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG89CSQ4 GO:0045475 1/112 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG89CSQ4 GO:0072499 1/112 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG81RSB0 GO:0003968 1/78 RNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] EOG841STR GO:0016020 29/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG841STR GO:0051781 26/106 positive regulation of cell division biological_process "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] EOG841STR GO:0007435 1/106 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG841STR GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG841STR GO:0007298 1/106 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG841STR GO:0008201 1/106 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG841STR GO:0004252 1/106 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG841STR GO:0005102 1/106 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG841STR GO:0005615 1/106 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG841STR GO:0008284 1/106 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG841STR GO:0031954 1/106 positive regulation of protein autophosphorylation biological_process "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] EOG841STR GO:0030031 1/106 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG841STR GO:0035099 1/106 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG841STR GO:0007443 1/106 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG841STR GO:0061327 1/106 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8W10V9 GO:0005634 25/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8W10V9 GO:0048812 1/103 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8W10V9 GO:0008157 1/103 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG82JR79 GO:0003700 24/73 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82JR79 GO:0043565 24/73 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82JR79 GO:0005634 22/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82JR79 GO:0007275 14/73 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG82JR79 GO:0001748 1/73 optic lobe placode development biological_process "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] EOG82JR79 GO:0004000 1/73 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG82VBZX GO:0004930 3/34 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG82VBZX GO:0016021 3/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N3Z GO:0003676 32/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S7N3Z GO:0016788 32/100 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8S7N3Z GO:0016442 26/100 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG8S7N3Z GO:0031047 25/100 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8S7N3Z GO:0005811 1/100 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8S7N3Z GO:0005875 1/100 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8D55F0 GO:0005634 25/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D55F0 GO:0007049 25/88 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8D55F0 GO:0006281 25/88 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8D55F0 GO:0017111 2/88 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8D55F0 GO:0005524 2/88 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82VBZM GO:0046658 1/59 anchored component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG82VBZM GO:0046928 1/59 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG8WSZVX GO:0008270 2/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WSZVX GO:0005634 2/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CG2SJ GO:0008233 2/68 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG808QR7 GO:0003735 2/13 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG808QR7 GO:0015935 2/13 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG808QR7 GO:0006412 2/13 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG89PDCJ GO:0006289 1/8 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG89PDCJ GO:0005524 1/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89PDCJ GO:0003677 1/8 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89PDCJ GO:0009432 1/8 SOS response biological_process "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023] EOG89PDCJ GO:0009381 1/8 excinuclease ABC activity molecular_function "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] EOG82589B GO:0008270 1/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82589B GO:0003735 1/20 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG82589B GO:0003676 1/20 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82589B GO:0006412 1/20 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG82589B GO:0015935 1/20 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG8DNHMJ GO:0005634 6/24 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DNHMJ GO:0043565 6/24 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8DNHMJ GO:0003700 6/24 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DNHMJ GO:0004000 1/24 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8DNHMR GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DNHMQ GO:0045454 1/85 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8DNHMQ GO:0009055 1/85 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8DNHMQ GO:0015035 1/85 protein disulfide oxidoreductase activity molecular_function "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] EOG80P6PP GO:0006909 5/13 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG80P6PP GO:0005856 5/13 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8Q2GWP GO:0018454 1/17 acetoacetyl-CoA reductase activity molecular_function "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] EOG8Q2GWP GO:0016491 1/17 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8DNHMX GO:0019185 1/127 snRNA-activating protein complex cellular_component "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] EOG8DNHMX GO:0007304 1/127 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8DNHMX GO:0007275 1/127 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8DNHMX GO:0043565 1/127 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8DNHMX GO:0042600 1/127 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8DNHMX GO:0005213 1/127 structural constituent of chorion molecular_function "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] EOG8DNHMX GO:0042796 1/127 snRNA transcription from RNA polymerase III promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] EOG8DNHMX GO:0065004 1/127 protein-DNA complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] EOG8DNHMX GO:0003681 1/127 bent DNA binding molecular_function "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] EOG8DNHMX GO:0042795 1/127 snRNA transcription from RNA polymerase II promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] EOG8DNHMX GO:0003677 1/127 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DNHMX GO:0005515 1/127 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8J9QCN GO:0005524 15/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8J9QCN GO:0016887 14/92 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8J9QCN GO:0015416 1/92 organic phosphonate transmembrane-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] EOG8G7FCR GO:0005975 35/112 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8G7FCR GO:0004553 34/112 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8G7FCR GO:0032450 1/112 maltose alpha-glucosidase activity molecular_function "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] EOG8NCPV8 GO:0016021 56/128 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NCPV8 GO:0005525 1/128 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8NCPV8 GO:0003746 1/128 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG82C0PP GO:0005272 34/119 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG82C0PP GO:0016021 32/119 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82C0PP GO:0016020 2/119 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8H1D98 GO:0006511 10/65 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8H1D98 GO:0008234 9/65 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8H1D98 GO:0008270 8/65 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MSGFN GO:0031461 2/4 cullin-RING ubiquitin ligase complex cellular_component "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] EOG8MSGFN GO:0006511 2/4 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG82C0PK GO:0042254 24/91 ribosome biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] EOG82C0PK GO:0005634 24/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82C0PK GO:0022008 1/91 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82C0PK GO:0005730 1/91 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG82C0PK GO:0042255 1/91 ribosome assembly biological_process "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma] EOG8J9QCX GO:0005525 26/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8J9QCX GO:0003924 25/90 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8J9QCX GO:0003746 23/90 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8J9QCX GO:0005739 14/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8J9QCX GO:0070125 14/90 mitochondrial translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] EOG8J9QCX GO:0006184 14/90 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8J9QCX GO:0005622 9/90 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8J9QCX GO:0005634 1/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J9QCX GO:0004781 1/90 sulfate adenylyltransferase (ATP) activity molecular_function "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] EOG8G7FC6 GO:0008076 33/158 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8G7FC6 GO:0005249 32/158 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8G7FC6 GO:0006813 1/158 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8G7FC6 GO:0034765 1/158 regulation of ion transmembrane transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] EOG8G7FC6 GO:0005251 1/158 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8G7FC6 GO:0060048 1/158 cardiac muscle contraction biological_process "Muscle contraction of cardiac muscle tissue." [GOC:dph] EOG8G7FC6 GO:0016021 1/158 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FC6 GO:0002027 1/158 regulation of heart rate biological_process "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] EOG8G7FC6 GO:0022843 1/158 voltage-gated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8G7FC6 GO:0001700 1/158 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8MSGF1 GO:0003700 6/22 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8KD90X GO:0016787 24/120 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8KD90X GO:0003824 6/120 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KD90X GO:0046872 3/120 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KD90X GO:0004725 3/120 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8JQ6DD GO:0017153 2/14 sodium:dicarboxylate symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] EOG8JQ6DD GO:0016020 2/14 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8JQ6DF GO:0006412 27/90 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8JQ6DF GO:0003735 27/90 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8JQ6DF GO:0005840 27/90 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8MD0K7 GO:0008270 1/3 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80P6P2 GO:0005975 1/7 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG80P6P2 GO:0003824 1/7 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG87WR2G GO:0016459 24/104 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG87WR2G GO:0005524 23/104 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87WR2G GO:0003774 23/104 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG87WR2G GO:0005856 5/104 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG87WR2G GO:0030175 1/104 filopodium cellular_component "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] EOG87WR2G GO:0006886 1/104 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG87WR2G GO:0042623 1/104 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG87WR2G GO:0043025 1/104 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG87WR2G GO:0046847 1/104 filopodium assembly biological_process "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] EOG87WR2G GO:0006200 1/104 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG87WR2G GO:0005515 1/104 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87WR2G GO:0007391 1/104 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG84BDGK GO:0016491 1/4 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8QFZV5 GO:0016853 1/13 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8SJ7V6 GO:0016021 24/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SJ7V6 GO:0006486 24/85 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8SJ7V6 GO:0005794 23/85 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8SJ7V6 GO:0046872 21/85 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SJ7V6 GO:0016757 21/85 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SJ7V6 GO:0004653 3/85 polypeptide N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] EOG8SJ7V6 GO:0005795 1/85 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8SJ7V6 GO:0000139 1/85 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8SJ7V6 GO:0007424 1/85 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8SJ7V6 GO:0009312 1/85 oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] EOG8QZB0S GO:0016021 30/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QZB0S GO:0035556 30/103 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8QZB0S GO:0000166 29/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8QZB0S GO:0009190 27/103 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8QZB0S GO:0016849 27/103 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8QZB0S GO:0004016 3/103 adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] EOG8QZB0S GO:0040015 1/103 negative regulation of multicellular organism growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8QZB0S GO:0042594 1/103 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8QZB0S GO:0006171 1/103 cAMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] EOG8QZB0S GO:0002165 1/103 instar larval or pupal development biological_process "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8QZB0S GO:0046872 1/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QZB0S GO:0005524 1/103 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QZB0Q GO:0003774 14/97 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8QZB0Q GO:0016459 14/97 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8QZB0Q GO:0005524 14/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QZB0Q GO:0007165 11/97 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8QZB0Q GO:0005856 9/97 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG81ZHSC GO:0016787 2/101 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R52JM GO:0005509 15/49 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8R52JM GO:0005886 4/49 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8R52JM GO:0005634 4/49 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8R52JM GO:0005737 4/49 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8R52JM GO:0007367 3/49 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8R52JM GO:0008270 3/49 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R52JM GO:0014018 3/49 neuroblast fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] EOG8R52JM GO:0060071 3/49 Wnt signaling pathway, planar cell polarity pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] EOG8R52JM GO:0030178 1/49 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8R52JM GO:0007275 1/49 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8R52JM GO:0030165 1/49 PDZ domain binding molecular_function "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] EOG8R52JM GO:0005515 1/49 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8R52JM GO:0016055 1/49 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG81ZHSF GO:0009228 1/5 thiamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] EOG81ZHSF GO:0006979 1/5 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG81ZHSF GO:0004417 1/5 hydroxyethylthiazole kinase activity molecular_function "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24215] EOG81ZHSF GO:0016209 1/5 antioxidant activity molecular_function "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] EOG81ZHSF GO:0051920 1/5 peroxiredoxin activity molecular_function "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] EOG81ZHSF GO:0016829 1/5 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG87WR50 GO:0005634 1/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87WR50 GO:0008270 1/22 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81ZHSH GO:0008233 46/128 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG81ZHSH GO:0016740 3/128 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81ZHSH GO:0016603 3/128 glutaminyl-peptide cyclotransferase activity molecular_function "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] EOG81ZHSH GO:0046872 2/128 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81ZHSH GO:0017186 2/128 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase biological_process "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] EOG81ZHSH GO:0005576 2/128 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81ZHSH GO:0004222 1/128 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG81ZHSH GO:0005615 1/128 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG81ZHSH GO:0006508 1/128 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG81ZHSH GO:0032504 1/128 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG81ZHSH GO:0050829 1/128 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG81ZHSH GO:0005739 1/128 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG81ZHSK GO:0005886 1/59 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81ZHSK GO:0016021 1/59 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81ZHSK GO:0050909 1/59 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8PCD64 GO:0005507 23/86 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8PCD64 GO:0008168 23/86 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8PCD64 GO:0006412 23/86 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8PCD64 GO:0006744 1/86 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8PCD64 GO:0031314 1/86 extrinsic component of mitochondrial inner membrane cellular_component "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] EOG8XH2DD GO:0046856 11/100 phosphatidylinositol dephosphorylation biological_process "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732] EOG8XH2DD GO:0052658 2/100 inositol-1,4,5-trisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800] EOG8XH2DD GO:0052659 2/100 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395] EOG8XH2DD GO:0004445 2/100 inositol-polyphosphate 5-phosphatase activity molecular_function "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] EOG8XH2DD GO:0046855 1/100 inositol phosphate dephosphorylation biological_process "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732] EOG8XH2DD GO:0016311 1/100 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8XH2DD GO:0046030 1/100 inositol trisphosphate phosphatase activity molecular_function "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf] EOG8XH2DG GO:0006826 23/81 iron ion transport biological_process "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8XH2DG GO:0008199 23/81 ferric iron binding molecular_function "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] EOG8XH2DG GO:0005576 23/81 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XH2DG GO:0006879 23/81 cellular iron ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] EOG8XH2DG GO:0042048 1/81 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8PRW50 GO:0005245 1/281 voltage-gated calcium channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] EOG8PRW50 GO:0045886 1/281 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8PRW50 GO:0048488 1/281 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8PRW50 GO:0019233 1/281 sensory perception of pain biological_process "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/] EOG8PRW50 GO:0045202 1/281 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PRW50 GO:0048786 1/281 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8PRW50 GO:0007528 1/281 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8PRW50 GO:0070588 1/281 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8PRW50 GO:0007274 1/281 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8PRW51 GO:0019187 28/100 beta-1,4-mannosyltransferase activity molecular_function "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646] EOG8PRW51 GO:0006688 1/100 glycosphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] EOG8PRW51 GO:0045434 1/100 negative regulation of female receptivity, post-mating biological_process "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] EOG8PRW51 GO:0016021 1/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PRW51 GO:0008049 1/100 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8PRW51 GO:0007299 1/100 ovarian follicle cell-cell adhesion biological_process "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] EOG8PRW51 GO:0045165 1/100 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG8PRW51 GO:0007293 1/100 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8PRW51 GO:0048477 1/100 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8PRW51 GO:0007298 1/100 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PRW51 GO:0007281 1/100 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8PRW51 GO:0016325 1/100 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8PRW51 GO:0030720 1/100 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG8PRW51 GO:0033227 1/100 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8PRW51 GO:0097502 1/100 mannosylation biological_process "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm] EOG8PRW51 GO:0016333 1/100 morphogenesis of follicular epithelium biological_process "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] EOG8PRW51 GO:0042248 1/100 maintenance of polarity of follicular epithelium biological_process "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf] EOG8PRW51 GO:0007411 1/100 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8PRW51 GO:0030707 1/100 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PRW51 GO:0001744 1/100 optic lobe placode formation biological_process "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] EOG8PRW51 GO:0046662 1/100 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG8PRW51 GO:0048935 1/100 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG8XH2DR GO:0004871 37/127 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8XH2DR GO:0005525 37/127 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8XH2DR GO:0003924 37/127 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8XH2DR GO:0007186 35/127 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8XH2DR GO:0001664 2/127 G-protein coupled receptor binding molecular_function "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] EOG8XH2DR GO:0031234 2/127 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG8XH2DR GO:0060158 2/127 phospholipase C-activating dopamine receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914] EOG8XH2DR GO:0007188 2/127 adenylate cyclase-modulating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] EOG8XH2DR GO:0005834 2/127 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG8XH2DR GO:0031683 2/127 G-protein beta/gamma-subunit complex binding molecular_function "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] EOG8XH2DR GO:0007601 1/127 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8XH2DR GO:0002385 1/127 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8XH2DR GO:0007629 1/127 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8XH2DR GO:0007608 1/127 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8XH2DR GO:0016199 1/127 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8XH2DR GO:0016027 1/127 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG8XH2DR GO:0071244 1/127 cellular response to carbon dioxide biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah] EOG8XH2DR GO:0043052 1/127 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8XH2DR GO:0046872 1/127 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XH2DR GO:0016056 1/127 rhodopsin mediated signaling pathway biological_process "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] EOG8XH2DR GO:0006897 1/127 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8XH2DR GO:0046673 1/127 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8XH2DR GO:0030322 1/127 stabilization of membrane potential biological_process "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] EOG8XH2DR GO:0007202 1/127 activation of phospholipase C activity biological_process "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] EOG8XH2DR GO:0016060 1/127 metarhodopsin inactivation biological_process "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] EOG8XH2DR GO:0016028 1/127 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8XH2DR GO:0005886 1/127 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XH2DR GO:0007602 1/127 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8PRW54 GO:0003995 85/195 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8PRW54 GO:0050660 84/195 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8PRW54 GO:0005777 82/195 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8PRW54 GO:0003997 82/195 acyl-CoA oxidase activity molecular_function "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] EOG8PRW54 GO:0006635 81/195 fatty acid beta-oxidation biological_process "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] EOG8PRW54 GO:0006629 1/195 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8PRW54 GO:0019395 1/195 fatty acid oxidation biological_process "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY] EOG8PRW54 GO:0006693 1/195 prostaglandin metabolic process biological_process "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732] EOG8PRW54 GO:0033540 1/195 fatty acid beta-oxidation using acyl-CoA oxidase biological_process "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136] EOG8PRW54 GO:0006091 1/195 generation of precursor metabolites and energy biological_process "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] EOG8PVRCP GO:0003676 30/107 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PVRCP GO:0008270 13/107 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRCP GO:0005634 13/107 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PVRCP GO:0006351 11/107 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8PVRCP GO:0003700 11/107 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8PVRCP GO:0006366 1/107 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8PVRCP GO:0006357 1/107 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8PVRCP GO:0046872 1/107 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PVRCP GO:0048813 1/107 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8PVRCP GO:0000981 1/107 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG86T5K6 GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86T5K6 GO:0003677 1/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QRKJG GO:0004618 37/104 phosphoglycerate kinase activity molecular_function "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804] EOG8QRKJG GO:0006096 37/104 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8QRKJG GO:0005524 34/104 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QRKJG GO:0007268 1/104 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8QRKJG GO:0016310 1/104 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8QRKJG GO:0031430 1/104 M band cellular_component "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] EOG8QRKJG GO:0030018 1/104 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8QRKJG GO:0046716 1/104 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG88KTRX GO:0008026 27/89 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG88KTRX GO:0005524 27/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88KTRX GO:0003676 27/89 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88KTRX GO:0008152 1/89 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG88KTRX GO:0022618 1/89 ribonucleoprotein complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] EOG88KTRX GO:0003724 1/89 RNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] EOG88KTRX GO:0016779 1/89 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG88KTRX GO:0005737 1/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88KTRX GO:0008344 1/89 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG88KTRX GO:0007528 1/89 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG88KTRX GO:0015030 1/89 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG88KTRX GO:0071254 1/89 cytoplasmic U snRNP body cellular_component "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] EOG88KTRX GO:0007629 1/89 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8PCD6P GO:0044255 23/93 cellular lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] EOG8PCD6P GO:0008374 19/93 O-acyltransferase activity molecular_function "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] EOG8PCD6P GO:0016287 7/93 glycerone-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17660] EOG8PCD6P GO:0005777 5/93 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8PCD6P GO:0008611 4/93 ether lipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] EOG8PCD6P GO:0004366 1/93 glycerol-3-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] EOG8323C4 GO:0007076 2/7 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG87H886 GO:0016021 1/2 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87H886 GO:0005230 1/2 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG88KTRP GO:0005634 28/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88KTRP GO:0003707 27/95 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG88KTRP GO:0008270 21/95 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88KTRP GO:0043565 21/95 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG88KTRP GO:0004887 15/95 thyroid hormone receptor activity molecular_function "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling] EOG88KTRP GO:0003700 12/95 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88KTRP GO:0006351 12/95 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88KTRP GO:0003677 7/95 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88KTRP GO:0046872 3/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88KTRP GO:0006030 1/95 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG88KTRP GO:0005576 1/95 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88KTRP GO:0004879 1/95 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG88KTRP GO:0030522 1/95 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG88KTRP GO:0008061 1/95 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8577MJ GO:0008234 36/141 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8577MJ GO:0008233 3/141 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8577MJ GO:0021952 2/141 central nervous system projection neuron axonogenesis biological_process "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8577MJ GO:0016929 2/141 SUMO-specific protease activity molecular_function "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] EOG8577MJ GO:0060997 2/141 dendritic spine morphogenesis biological_process "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] EOG8577MJ GO:0005634 2/141 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8577MJ GO:0016926 2/141 protein desumoylation biological_process "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] EOG8577MJ GO:0003676 1/141 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8577MJ GO:0008270 1/141 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8577MJ GO:0007476 1/141 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8577MJ GO:0060548 1/141 negative regulation of cell death biological_process "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] EOG8577MJ GO:0005737 1/141 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8577MJ GO:0045134 1/141 uridine-diphosphatase activity molecular_function "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] EOG8577MJ GO:0007411 1/141 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8PRW5S GO:0003824 22/87 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8PRW5S GO:0004300 3/87 enoyl-CoA hydratase activity molecular_function "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] EOG8XD64W GO:0006260 1/16 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8XD64W GO:0008408 1/16 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG8XD64Z GO:0016747 27/55 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8PCD6H GO:0000049 30/94 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG8PCD6H GO:0005737 30/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PCD6H GO:0005524 30/94 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PCD6H GO:0004826 25/94 phenylalanine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] EOG8PCD6H GO:0006432 25/94 phenylalanyl-tRNA aminoacylation biological_process "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8PCD6H GO:0004812 5/94 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8PCD6H GO:0043039 3/94 tRNA aminoacylation biological_process "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] EOG8PCD6H GO:0006418 2/94 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG8T4GB1 GO:0000105 1/4 histidine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] EOG8T4GB1 GO:0005737 1/4 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4GB1 GO:0003879 1/4 ATP phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] EOG81ZHS4 GO:0005524 23/145 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81ZHS4 GO:0005829 21/145 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG81ZHS4 GO:0046872 21/145 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81ZHS4 GO:0004792 21/145 thiosulfate sulfurtransferase activity molecular_function "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884] EOG81ZHS4 GO:0002143 21/145 tRNA wobble position uridine thiolation biological_process "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] EOG81ZHS4 GO:0016787 20/145 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG81ZHS4 GO:0006777 19/145 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG81ZHS4 GO:0018192 19/145 enzyme active site formation via cysteine modification to L-cysteine persulfide biological_process "The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269] EOG81ZHS4 GO:0061604 14/145 molybdopterin-synthase sulfurtransferase activity molecular_function "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186] EOG81ZHS4 GO:0061605 14/145 molybdopterin-synthase adenylyltransferase activity molecular_function "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186] EOG81ZHS4 GO:0016779 5/145 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG81ZHS4 GO:0003824 2/145 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81ZHS4 GO:0016740 2/145 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81ZHS4 GO:0004842 1/145 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81ZHS4 GO:0032324 1/145 molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] EOG81ZHS4 GO:0016575 1/145 histone deacetylation biological_process "The modification of histones by removal of acetyl groups." [GOC:ai] EOG81ZHS4 GO:0004407 1/145 histone deacetylase activity molecular_function "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272] EOG81ZHS4 GO:0005680 1/145 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG805VHB GO:0015074 4/18 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG805VHB GO:0003676 3/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG805VHB GO:0004190 2/18 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG805VHB GO:0003723 1/18 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG805VHB GO:0003964 1/18 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG81ZHS7 GO:0016887 1/6 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG81ZHS7 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81ZHS9 GO:0033557 16/86 Slx1-Slx4 complex cellular_component "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] EOG81ZHS9 GO:0006281 16/86 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG81ZHS9 GO:0006310 16/86 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG81ZHS9 GO:0017108 16/86 5'-flap endonuclease activity molecular_function "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] EOG81ZHS9 GO:0046872 14/86 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81ZHS9 GO:0005515 1/86 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81ZHS9 GO:0007095 1/86 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG81ZHS9 GO:0008270 1/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG805VHT GO:0005634 5/39 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG805VHT GO:0000245 5/39 spliceosomal complex assembly biological_process "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] EOG8SJ7VF GO:0005267 45/160 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8SJ7VF GO:0016021 43/160 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SJ7VF GO:0016020 2/160 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8SJ7VF GO:0046982 2/160 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8SJ7VF GO:0071805 2/160 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8S4RZ0 GO:0016021 116/397 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RZ0 GO:0005215 113/397 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8S4RZ0 GO:0055085 6/397 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8S4RZ0 GO:0015267 5/397 channel activity molecular_function "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] EOG8S4RZ0 GO:0003014 3/397 renal system process biological_process "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] EOG8S4RZ0 GO:0016020 3/397 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RZ0 GO:0015250 1/397 water channel activity molecular_function "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] EOG8S4RZ0 GO:0046662 1/397 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG8S4RZ0 GO:0006833 1/397 water transport biological_process "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8S4RZ0 GO:0030104 1/397 water homeostasis biological_process "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] EOG8JDKNN GO:0005576 1/126 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JDKNN GO:0008592 1/126 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8JDKNN GO:0009620 1/126 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG8JDKNN GO:0008045 1/126 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8JDKNN GO:0006967 1/126 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8JDKNN GO:0008083 1/126 growth factor activity molecular_function "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] EOG8JDKNN GO:0000578 1/126 embryonic axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] EOG8JDKNN GO:0019732 1/126 antifungal humoral response biological_process "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8JDKNN GO:0031640 1/126 killing of cells of other organism biological_process "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] EOG8JDKNN GO:0005615 1/126 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JDKNN GO:0031334 1/126 positive regulation of protein complex assembly biological_process "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] EOG8JDKNN GO:0005125 1/126 cytokine activity molecular_function "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] EOG8JDKNN GO:0007310 1/126 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8JDKNN GO:0008063 1/126 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8JDKNN GO:0007311 1/126 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8JDKNN GO:0043234 1/126 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8JDKNN GO:0050830 1/126 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8JDKNN GO:0005121 1/126 Toll binding molecular_function "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] EOG8JDKNN GO:0016015 1/126 morphogen activity molecular_function "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] EOG8JDKNN GO:0050832 1/126 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8JDKNN GO:0045087 1/126 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8JDKNN GO:0042803 1/126 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8JDKNN GO:0006965 1/126 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] EOG8JDKNN GO:0006952 1/126 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8JDKNN GO:0009953 1/126 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8JDKNN GO:0006955 1/126 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8JDKNN GO:0009950 1/126 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG85XBD5 GO:0005509 62/282 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG85XBD5 GO:0048190 1/282 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG85XBD5 GO:0048812 1/282 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8QNQCR GO:0003729 1/85 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8QNQCR GO:0071011 1/85 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8QNQCR GO:0042386 1/85 hemocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] EOG8QNQCR GO:0030097 1/85 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8QNQCR GO:0000398 1/85 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8B2WC8 GO:0048149 1/85 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8B2WC8 GO:0045887 1/85 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8B2WC8 GO:0034452 1/85 dynactin binding molecular_function "Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah] EOG8B2WC8 GO:0005802 1/85 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG8QNQCC GO:0016021 1/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QNQCC GO:0015171 1/3 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG87M4CV GO:0016021 1/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87M4CV GO:0043682 1/3 copper-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl] EOG87M4CV GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87M4CV GO:0046872 1/3 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88SK76 GO:0005524 1/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88SK76 GO:0004812 1/8 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG88SK76 GO:0016788 1/8 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG88SK76 GO:0019478 1/8 D-amino acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] EOG88SK76 GO:0006418 1/8 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG88SK76 GO:0005737 1/8 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8616JC GO:0003993 25/94 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8616JC GO:0052826 2/94 inositol hexakisphosphate 2-phosphatase activity molecular_function "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62] EOG8XWJCQ GO:0006659 1/7 phosphatidylserine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] EOG8XWJCZ GO:0003824 18/88 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8XWJCZ GO:0016740 3/88 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8XWJCZ GO:0004663 2/88 Rab geranylgeranyltransferase activity molecular_function "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] EOG8XWJCZ GO:0008152 1/88 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8XWJCZ GO:0004662 1/88 CAAX-protein geranylgeranyltransferase activity molecular_function "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] EOG8XWJCZ GO:0004661 1/88 protein geranylgeranyltransferase activity molecular_function "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] EOG8XWJCZ GO:0022008 1/88 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8XWJCZ GO:0035050 1/88 embryonic heart tube development biological_process "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] EOG8616JH GO:0004402 2/87 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8616JH GO:0036098 1/87 male germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937] EOG8616JH GO:0030707 1/87 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8616JH GO:0010468 1/87 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8616JH GO:0030723 1/87 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8616JH GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8616JH GO:0008584 1/87 male gonad development biological_process "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] EOG8616JH GO:0007281 1/87 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8616JH GO:0031490 1/87 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG8616JW GO:0016491 19/97 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8BK7HM GO:0005524 25/102 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BK7HM GO:0016020 24/102 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BK7HM GO:0007169 23/102 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8BK7HM GO:0004714 23/102 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8BK7HM GO:0004713 2/102 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8BK7HM GO:0004715 2/102 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8BK7HM GO:0008355 1/102 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8BK7HM GO:0016021 1/102 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BK7HM GO:0090303 1/102 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8BK7HM GO:0007350 1/102 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8BK7HM GO:0035310 1/102 notum cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] EOG8BK7HM GO:0007472 1/102 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8BK7HM GO:0007474 1/102 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8BK7HM GO:0016337 1/102 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG8BK7HM GO:0016318 1/102 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8BK7HM GO:0042694 1/102 muscle cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] EOG8BK7HM GO:0043066 1/102 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8BK7HM GO:0007309 1/102 oocyte axis specification biological_process "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8BK7HM GO:0007298 1/102 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8BK7HM GO:0007421 1/102 stomatogastric nervous system development biological_process "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] EOG8BK7HM GO:0003015 1/102 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG8BK7HM GO:0008406 1/102 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8BK7HM GO:0009880 1/102 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8BK7HM GO:0007391 1/102 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8BK7HM GO:0046843 1/102 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8BK7HM GO:0009952 1/102 anterior/posterior pattern specification biological_process "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8BK7HM GO:0016203 1/102 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8BK7HM GO:2001234 1/102 negative regulation of apoptotic signaling pathway biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] EOG8BK7HM GO:0007473 1/102 wing disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] EOG8BK7HM GO:0008071 1/102 maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded biological_process "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8BK7HM GO:0007390 1/102 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8BK7HM GO:0030381 1/102 chorion-containing eggshell pattern formation biological_process "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] EOG8BK7HM GO:0046845 1/102 branched duct epithelial cell fate determination, open tracheal system biological_process "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] EOG8BK7HM GO:0007469 1/102 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG8BK7HM GO:0001709 1/102 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8BK7HM GO:0007458 1/102 progression of morphogenetic furrow involved in compound eye morphogenesis biological_process "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] EOG8BK7HM GO:0006468 1/102 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8BK7HM GO:0048546 1/102 digestive tract morphogenesis biological_process "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] EOG8BK7HM GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8BK7HM GO:0007369 1/102 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8BK7HM GO:0035309 1/102 wing and notum subfield formation biological_process "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] EOG8BK7HM GO:0009953 1/102 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8BK7HM GO:0061331 1/102 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8BK7HM GO:0048749 1/102 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8BK7HM GO:0007173 1/102 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8BK7HM GO:0045468 1/102 regulation of R8 cell spacing in compound eye biological_process "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339] EOG8BK7HM GO:0001751 1/102 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8BK7HM GO:0048139 1/102 female germ-line cyst encapsulation biological_process "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid] EOG8BK7HM GO:0007346 1/102 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8BK7HM GO:0045466 1/102 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG8BK7HM GO:0007477 1/102 notum development biological_process "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] EOG8BK7HM GO:0035088 1/102 establishment or maintenance of apical/basal cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] EOG8BK7HM GO:0008284 1/102 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG8BK7HM GO:0007431 1/102 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8BK7HM GO:0005006 1/102 epidermal growth factor-activated receptor activity molecular_function "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf] EOG8BK7HM GO:2000134 1/102 negative regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8BK7HM GO:0007479 1/102 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8BK7HM GO:0007314 1/102 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8BK7HM GO:0035202 1/102 tracheal pit formation in open tracheal system biological_process "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584] EOG8BK7HM GO:0004888 1/102 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8BK7HM GO:0046673 1/102 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8BK7HM GO:0007420 1/102 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8BK7HM GO:0007482 1/102 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8BK7HM GO:0035160 1/102 maintenance of epithelial integrity, open tracheal system biological_process "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] EOG8BK7HM GO:0000086 1/102 G2/M transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] EOG8BK7HM GO:0045610 1/102 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8BK7HM GO:0035225 1/102 determination of genital disc primordium biological_process "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] EOG8BK7HM GO:0016333 1/102 morphogenesis of follicular epithelium biological_process "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] EOG8BK7HM GO:0030718 1/102 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8BK7HM GO:0002009 1/102 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8BK7HM GO:0007310 1/102 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8BK7HM GO:0001745 1/102 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8BK7HM GO:0007455 1/102 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8BK7HM GO:0048149 1/102 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8BK7HM GO:0030031 1/102 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8BK7HM GO:0007367 1/102 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8BK7HM GO:0007443 1/102 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8BK7HM GO:0042676 1/102 compound eye cone cell fate commitment biological_process "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] EOG8BK7HM GO:0007422 1/102 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8BK7HM GO:0007444 1/102 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8BK7HM GO:0005886 1/102 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BK7HM GO:0048140 1/102 male germ-line cyst encapsulation biological_process "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336] EOG8BK7HM GO:0001752 1/102 compound eye photoreceptor fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] EOG8BK7HM GO:0001654 1/102 eye development biological_process "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] EOG8BK7HM GO:0008586 1/102 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8BK7HM GO:0018108 1/102 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8BK7HM GO:0001742 1/102 oenocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] EOG8BK7HM GO:0048865 1/102 stem cell fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] EOG8BK7HM GO:0016787 1/102 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BK7HM GO:0022008 1/102 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8BK7HM GO:0016330 1/102 second mitotic wave involved in compound eye morphogenesis biological_process "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] EOG8BK7HM GO:0035277 1/102 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8BK7HM GO:0007424 1/102 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8BK7HM GO:0007476 1/102 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8MKQZB GO:0006886 25/85 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8MKQZB GO:0008565 25/85 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8MKQZB GO:0016192 24/85 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8MKQZB GO:0030117 24/85 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG8MKQZB GO:0022008 1/85 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MKQZB GO:0016183 1/85 synaptic vesicle coating biological_process "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709] EOG8MKQZB GO:0007269 1/85 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8MKQZB GO:0030135 1/85 coated vesicle cellular_component "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] EOG8MKQZB GO:0030122 1/85 AP-2 adaptor complex cellular_component "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499] EOG8MKQZB GO:0008021 1/85 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8MKQZB GO:0006897 1/85 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8MKQZB GO:0006901 1/85 vesicle coating biological_process "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] EOG8MKQZD GO:0017153 1/4 sodium:dicarboxylate symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] EOG8MKQZD GO:0016020 1/4 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG87M4C2 GO:0016021 11/75 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87M4C2 GO:0022891 10/75 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG87M4C2 GO:0022857 1/75 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG87M4C2 GO:0008643 1/75 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8XWJC2 GO:0005272 70/161 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8XWJC2 GO:0016021 67/161 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJC2 GO:0016020 3/161 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XWJC2 GO:0005886 1/161 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XWJC2 GO:0009415 1/161 response to water biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] EOG8XWJC2 GO:0035002 1/161 liquid clearance, open tracheal system biological_process "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] EOG8XWJC2 GO:0071462 1/161 cellular response to water stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] EOG8XWJC2 GO:0042756 1/161 drinking behavior biological_process "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr] EOG822D26 GO:0004602 11/18 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG822D26 GO:0006979 11/18 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG822D27 GO:0004867 4/12 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8616J3 GO:0042597 1/3 periplasmic space cellular_component "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] EOG8616J3 GO:0030151 1/3 molybdenum ion binding molecular_function "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] EOG8616J3 GO:0051539 1/3 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8616J3 GO:0008940 1/3 nitrate reductase activity molecular_function "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4] EOG8616J3 GO:0042128 1/3 nitrate assimilation biological_process "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899] EOG88SK7H GO:0006749 99/277 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG88SK7H GO:0003840 99/277 gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] EOG88SK7H GO:0003810 1/277 protein-glutamine gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] EOG88SK7H GO:0032504 1/277 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG88SK7H GO:0048812 1/277 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG88SK7H GO:0005615 1/277 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8616J9 GO:0003677 11/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8616J9 GO:0004518 10/71 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8616J9 GO:0004527 1/71 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG88SK7J GO:0003887 3/7 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG88SK7J GO:0003677 3/7 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8W9MMG GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QNQC3 GO:0003735 22/165 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8QNQC3 GO:0000166 22/165 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8QNQC3 GO:0005840 22/165 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8QNQC3 GO:0006412 22/165 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8QNQC3 GO:0042623 2/165 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8QNQC3 GO:0030286 2/165 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8QNQC3 GO:0007018 2/165 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8QNQC3 GO:0006200 2/165 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8QNQC3 GO:0051298 1/165 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8QNQC3 GO:0007283 1/165 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8QNQC3 GO:0005875 1/165 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG80S2VT GO:0004494 3/7 methylmalonyl-CoA mutase activity molecular_function "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22891] EOG80S2VT GO:0046872 3/7 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80S2VT GO:0031419 3/7 cobalamin binding molecular_function "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] EOG80S2VT GO:0047548 1/7 2-methyleneglutarate mutase activity molecular_function "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13796] EOG8QVFSN GO:0046872 1/8 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QVFSN GO:0004641 1/8 phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035] EOG8QVFSN GO:0006189 1/8 'de novo' IMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] EOG8QVFSN GO:0005524 1/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QVFSN GO:0005737 1/8 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QVFSN GO:0016742 1/8 hydroxymethyl-, formyl- and related transferase activity molecular_function "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah] EOG8QVFSN GO:0009113 1/8 purine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732] EOG8QVFSN GO:0004637 1/8 phosphoribosylamine-glycine ligase activity molecular_function "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456] EOG8QVFSD GO:0000166 24/102 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8QVFSD GO:0003676 23/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QVFSD GO:0030849 1/102 autosome cellular_component "Any chromosome other than a sex chromosome." [GOC:mah] EOG8QVFSD GO:0005694 1/102 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8QVFSD GO:0003729 1/102 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8QVFSD GO:0003723 1/102 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8QVFSD GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QVFSD GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QVFSD GO:0003682 1/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8KH597 GO:0016021 55/198 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KH597 GO:0005230 53/198 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8KH597 GO:0005886 44/198 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KH597 GO:0030054 41/198 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8KH597 GO:0045202 41/198 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8KH597 GO:0019183 2/198 histamine-gated chloride channel complex cellular_component "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] EOG8KH597 GO:1902476 2/198 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG8KH597 GO:0019182 2/198 histamine-gated chloride channel activity molecular_function "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8KH597 GO:0006811 2/198 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8KH597 GO:0043052 2/198 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8KH597 GO:0006821 2/198 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8KH597 GO:0009636 1/198 response to toxic substance biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] EOG8KH597 GO:0045472 1/198 response to ether biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] EOG8KH597 GO:0007268 1/198 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8KH597 GO:0030534 1/198 adult behavior biological_process "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] EOG8KH595 GO:0005524 14/25 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KH595 GO:0007018 14/25 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8KH595 GO:0005874 14/25 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8KH595 GO:0003777 14/25 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8KH595 GO:0005871 14/25 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8KH595 GO:0003677 6/25 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8KH595 GO:0006281 6/25 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8KH595 GO:0007143 1/25 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8KH595 GO:0051296 1/25 establishment of meiotic spindle orientation biological_process "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] EOG8KH595 GO:0032837 1/25 distributive segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] EOG8KH595 GO:0045132 1/25 meiotic chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] EOG8KH595 GO:0031116 1/25 positive regulation of microtubule polymerization biological_process "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] EOG8KH595 GO:0007057 1/25 spindle assembly involved in female meiosis I biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] EOG8KH595 GO:0051010 1/25 microtubule plus-end binding molecular_function "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] EOG8KH595 GO:0007052 1/25 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8KH595 GO:0005737 1/25 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X3KHC GO:0016021 6/14 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X3KHC GO:0006810 5/14 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8X3KHC GO:0055085 1/14 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG80GG71 GO:0003676 20/947 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG71 GO:0008270 20/947 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80GG71 GO:0003677 3/947 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80GG71 GO:0005634 3/947 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80GG71 GO:0004190 2/947 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG80GG71 GO:0003964 2/947 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG80GG71 GO:0003723 2/947 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG80GG71 GO:0000786 1/947 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG80GG71 GO:0015074 1/947 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80GG71 GO:0004812 1/947 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG80GG71 GO:0006334 1/947 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8W6RDC GO:0003676 3/5 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W6RDC GO:0005634 2/5 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8W6RDC GO:0008270 2/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82Z741 GO:0005524 21/85 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82Z741 GO:0004672 16/85 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG82Z741 GO:0004674 6/85 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG82Z741 GO:0008898 2/85 S-adenosylmethionine-homocysteine S-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] EOG82Z741 GO:0005515 1/85 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82Z741 GO:0048813 1/85 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG82Z741 GO:0006468 1/85 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG82Z741 GO:0035612 1/85 AP-2 adaptor complex binding molecular_function "Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499] EOG82Z741 GO:0008356 1/85 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG82Z741 GO:0043025 1/85 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG82Z741 GO:2000369 1/85 regulation of clathrin-mediated endocytosis biological_process "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah] EOG82Z741 GO:0030424 1/85 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG82Z741 GO:0030425 1/85 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8GQSMC GO:0006915 2/38 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8GQSMC GO:0005634 2/38 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GQSMC GO:0003676 1/38 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F20J0 GO:0016907 21/103 G-protein coupled acetylcholine receptor activity molecular_function "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] EOG8F20J0 GO:0005887 21/103 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20J0 GO:0016021 6/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20J0 GO:0004930 5/103 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8F20J0 GO:0004715 2/103 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8F20J0 GO:0045211 1/103 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8F20J0 GO:0007200 1/103 phospholipase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8F20J0 GO:0007213 1/103 G-protein coupled acetylcholine receptor signaling pathway biological_process "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] EOG8F20J0 GO:0030054 1/103 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8F20J0 GO:0008227 1/103 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8F20J2 GO:0003676 1/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F20J2 GO:0003700 1/7 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8F20J2 GO:0008026 1/7 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8F20J2 GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F20J2 GO:0004871 1/7 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8F20J2 GO:0005622 1/7 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8F20J2 GO:0006935 1/7 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG8F20J4 GO:0005576 6/15 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8F20J4 GO:0008061 6/15 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8F20J4 GO:0006030 6/15 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG869T9D GO:0003735 2/8 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG869T9D GO:0005840 2/8 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG869T9D GO:0006412 2/8 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8VMHVP GO:0008236 27/97 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8VMHVP GO:0004180 1/97 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8NKF97 GO:0008324 44/191 cation transmembrane transporter activity molecular_function "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] EOG8GQSMR GO:0005634 7/40 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82NMDS GO:0016021 30/109 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82NMDS GO:0055085 30/109 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8N8TMF GO:0042384 1/130 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG82NMDQ GO:0005509 4/11 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG82NMDQ GO:0004571 4/11 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity molecular_function "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] EOG82NMDQ GO:0016020 4/11 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82NMDP GO:0050660 6/13 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG82NMDP GO:0008762 5/13 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG82NMDP GO:0016614 1/13 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8TTK0Q GO:0008270 24/79 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TTK0Q GO:0003677 2/79 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TTK0Q GO:0005634 2/79 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTK0Q GO:0007005 1/79 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8TTK0Q GO:0006470 1/79 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8TTK0Q GO:0048565 1/79 digestive tract development biological_process "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] EOG8TTK0Q GO:0005886 1/79 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TTK0Q GO:0035335 1/79 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8TTK0Q GO:0051046 1/79 regulation of secretion biological_process "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] EOG8TTK0Q GO:0030382 1/79 sperm mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] EOG8TTK0Q GO:0005737 1/79 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TTK0Q GO:0004725 1/79 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8K3PDW GO:0070403 1/2 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG8K3PDW GO:0003857 1/2 3-hydroxyacyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] EOG8K3PDW GO:0006631 1/2 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG82NMDF GO:0005524 21/50 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82NMDF GO:0004713 18/50 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG82NMDF GO:0016021 3/50 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82NMDF GO:0004672 2/50 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG82NMDF GO:0018108 1/50 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG82NMDF GO:0016772 1/50 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG82NMDF GO:0006468 1/50 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8Z38W1 GO:0006351 2/91 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8Z38W1 GO:0003899 2/91 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8Z38W1 GO:0003700 1/91 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z38W1 GO:0016021 1/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z38W1 GO:0043565 1/91 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82NMDM GO:0003743 1/15 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG82NMDM GO:0016779 1/15 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG82NMDM GO:0003924 1/15 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG82NMDM GO:0005525 1/15 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG82NMDM GO:0005622 1/15 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8JDKPK GO:0031032 28/308 actomyosin structure organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] EOG8JDKPK GO:0003779 3/308 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8JDKPK GO:0007520 1/308 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8JDKPK GO:0008360 1/308 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8JDKPK GO:0004252 1/308 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8JDKPK GO:1901739 1/308 regulation of myoblast fusion biological_process "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] EOG8JDKPK GO:0006939 1/308 smooth muscle contraction biological_process "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] EOG8JDKPK GO:0005865 1/308 striated muscle thin filament cellular_component "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] EOG8JDKPK GO:0005515 1/308 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JDKPK GO:0070594 1/308 juvenile hormone response element binding molecular_function "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872] EOG8JDKPK GO:0035626 1/308 juvenile hormone mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] EOG8JDKPK GO:0007155 1/308 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8Z38WJ GO:0008061 10/45 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8Z38WJ GO:0005576 10/45 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z38WJ GO:0006030 10/45 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG883GMR GO:0048813 1/106 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG883GMR GO:0045464 1/106 R8 cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] EOG883GMR GO:0045465 1/106 R8 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] EOG883GMR GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG883GMR GO:0007420 1/106 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG883GMR GO:0045433 1/106 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG883GMR GO:0006366 1/106 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG883GMR GO:0007438 1/106 oenocyte development biological_process "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] EOG883GMR GO:0007460 1/106 R8 cell fate commitment biological_process "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG883GMR GO:0001748 1/106 optic lobe placode development biological_process "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] EOG883GMR GO:0008038 1/106 neuron recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] EOG883GMR GO:0046982 1/106 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG883GMR GO:0007422 1/106 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG883GMR GO:0045165 1/106 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG883GMR GO:0007399 1/106 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG883GMR GO:0003677 1/106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG883GMR GO:0007224 1/106 smoothened signaling pathway biological_process "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] EOG883GMR GO:0001746 1/106 Bolwig's organ morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] EOG883GMR GO:0007423 1/106 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG883GMR GO:0048666 1/106 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG883GMR GO:0007173 1/106 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG883GMR GO:0048801 1/106 antennal joint morphogenesis biological_process "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid] EOG883GMR GO:0007455 1/106 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG883GMR GO:0016360 1/106 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG883GMR GO:0000187 1/106 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG883GMR GO:0007605 1/106 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG883GMR GO:0048800 1/106 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG883GMR GO:0045944 1/106 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG883GMR GO:0016330 1/106 second mitotic wave involved in compound eye morphogenesis biological_process "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] EOG883GMR GO:0001745 1/106 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG82NMD4 GO:0045177 1/151 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG82NMD4 GO:0030424 1/151 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG82NMD4 GO:0005938 1/151 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG82NMD4 GO:0035316 1/151 non-sensory hair organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] EOG82NMD4 GO:0035317 1/151 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG82NMD4 GO:0045860 1/151 positive regulation of protein kinase activity biological_process "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG82NMD4 GO:0044297 1/151 cell body cellular_component "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] EOG82NMD4 GO:0005515 1/151 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82NMD4 GO:0048800 1/151 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG82NMD4 GO:0030425 1/151 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG82NMD4 GO:0050773 1/151 regulation of dendrite development biological_process "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] EOG82NMD4 GO:0008407 1/151 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG82NMD4 GO:0007476 1/151 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG82NMD4 GO:0048601 1/151 oocyte morphogenesis biological_process "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] EOG82NMD4 GO:0042052 1/151 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG82NMD4 GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82NMD4 GO:0070593 1/151 dendrite self-avoidance biological_process "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] EOG82NMD4 GO:0048814 1/151 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG82NMD4 GO:0045893 1/151 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82NMD4 GO:0006351 1/151 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8M682W GO:0008146 1/2 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QJV3W GO:0046872 4/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QJV3W GO:0003676 2/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV3W GO:0042302 1/21 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8QJV3W GO:0008270 1/21 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N8TM1 GO:0043066 22/68 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8N8TM1 GO:0048812 1/68 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8TXF7N GO:0016021 1/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z38WW GO:0005525 4/10 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8Z38WW GO:0007264 4/10 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8THZ80 GO:0016787 3/145 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8THZ80 GO:0016791 3/145 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8THZ80 GO:0016311 2/145 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8VMHV8 GO:0045454 8/91 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8VMHV8 GO:0003756 1/91 protein disulfide isomerase activity molecular_function "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] EOG8W6RD1 GO:0003676 26/237 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W6RD1 GO:0008270 25/237 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8W6RD1 GO:0003677 1/237 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8W6RD1 GO:0004523 1/237 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8W6RD1 GO:0003964 1/237 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8W6RD1 GO:0003723 1/237 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8W6RD2 GO:0009279 1/7 cell outer membrane cellular_component "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254] EOG8W6RD2 GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20JZ GO:0005887 1/87 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20JZ GO:0061028 1/87 establishment of endothelial barrier biological_process "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph] EOG8F20JZ GO:0060576 1/87 intestinal epithelial cell development biological_process "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] EOG8F20JZ GO:0019991 1/87 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8F20JZ GO:0005920 1/87 smooth septate junction cellular_component "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] EOG8F20JZ GO:0007496 1/87 anterior midgut development biological_process "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] EOG8BZQGQ GO:0003755 19/79 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8BZQGQ GO:0006457 19/79 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8BZQGQ GO:0008270 18/79 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BZQGQ GO:0005622 14/79 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8KH59H GO:0004402 1/15 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8B8MT2 GO:0000226 28/96 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8B8MT2 GO:0005874 27/96 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8B8MT2 GO:0016787 24/96 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8B8MT2 GO:0060052 1/96 neurofilament cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph] EOG8B8MT2 GO:0048749 1/96 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8B8MT2 GO:0008017 1/96 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8B8MT2 GO:0007399 1/96 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8B8MT2 GO:0015630 1/96 microtubule cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] EOG8B8MT2 GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8B8MT2 GO:0048813 1/96 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8B8MT2 GO:0008088 1/96 axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] EOG8B8MT2 GO:0005875 1/96 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8B8MT2 GO:0008355 1/96 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8B8MT2 GO:0007528 1/96 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8B8MT2 GO:0007409 1/96 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8B8MT2 GO:0043524 1/96 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8B8MT2 GO:0019900 1/96 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG8B8MT2 GO:0008582 1/96 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8B8MT2 GO:0005737 1/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B8MT2 GO:0007017 1/96 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG89626V GO:0019843 15/94 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG89626V GO:0003723 13/94 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG89626V GO:0005622 12/94 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89626V GO:0030529 4/94 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG89626V GO:0019013 4/94 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG89626S GO:0006555 20/85 methionine metabolic process biological_process "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG89626S GO:0035999 20/85 tetrahydrofolate interconversion biological_process "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] EOG89626S GO:0004489 20/85 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] EOG8KPWQS GO:0032968 1/88 positive regulation of transcription elongation from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] EOG8KPWQS GO:0022008 1/88 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KPWQS GO:0005694 1/88 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8KPWQS GO:0035101 1/88 FACT complex cellular_component "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] EOG8KPWQS GO:0006260 1/88 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8KPWQS GO:0001672 1/88 regulation of chromatin assembly or disassembly biological_process "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] EOG8KPWQS GO:0003682 1/88 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8KPWQS GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8KPWQS GO:0006281 1/88 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8KPWQS GO:0006351 1/88 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8KPWQS GO:0005097 1/88 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8H48K0 GO:0008270 3/55 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8H48K0 GO:0006730 3/55 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8H48K0 GO:0004089 3/55 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8NCPWD GO:0005747 21/73 mitochondrial respiratory chain complex I cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] EOG8NCPWD GO:0048244 1/73 phytanoyl-CoA dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068] EOG8HTC62 GO:0005524 24/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HTC62 GO:0004674 22/99 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8HTC62 GO:0008353 2/99 RNA polymerase II carboxy-terminal domain kinase activity molecular_function "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] EOG8HTC62 GO:0030332 1/99 cyclin binding molecular_function "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] EOG8HTC62 GO:0006468 1/99 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8HTC62 GO:0070816 1/99 phosphorylation of RNA polymerase II C-terminal domain biological_process "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] EOG8HTC62 GO:0019908 1/99 nuclear cyclin-dependent protein kinase holoenzyme complex cellular_component "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] EOG8HTC62 GO:0006909 1/99 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8HTC62 GO:0005700 1/99 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8HTC62 GO:0000228 1/99 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8HTC62 GO:0004693 1/99 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8HTC62 GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8HTC62 GO:0005703 1/99 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG8HTC60 GO:0032440 2/104 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8HTC66 GO:0006351 8/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8HTC66 GO:0005737 8/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HTC66 GO:0035330 8/92 regulation of hippo signaling biological_process "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] EOG8HTC66 GO:0016324 8/92 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8HTC66 GO:0006355 8/92 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8HTC66 GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8HTC66 GO:0060253 1/92 negative regulation of glial cell proliferation biological_process "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] EOG8HTC66 GO:0045177 1/92 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8HTC66 GO:0001745 1/92 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8HTC66 GO:0036375 1/92 Kibra-Ex-Mer complex cellular_component "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598] EOG8XKXPH GO:0016020 142/797 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XKXPH GO:0005515 4/797 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XKXPH GO:0015031 1/797 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8XKXPH GO:0046331 1/797 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XKXPH GO:0005789 1/797 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8XKXPH GO:0016021 1/797 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DRCSB GO:0004252 26/87 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8DRCSB GO:0006508 1/87 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8DRCSB GO:0035187 1/87 hatching behavior biological_process "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] EOG8DRCSB GO:0016486 1/87 peptide hormone processing biological_process "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] EOG8DRCSB GO:0005615 1/87 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8DRCSB GO:0007218 1/87 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8DRCSB GO:0035180 1/87 larval wandering behavior biological_process "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] EOG8DRCSB GO:0002165 1/87 instar larval or pupal development biological_process "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8DRCSB GO:0008233 1/87 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8DRCSB GO:0005576 1/87 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8DRCSB GO:0033500 1/87 carbohydrate homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] EOG8PK4R7 GO:0016791 1/10 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8NP9K1 GO:0008137 9/57 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8NP9K1 GO:0042773 6/57 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8NP9K1 GO:0006120 1/57 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG8NP9K1 GO:0031966 1/57 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG8NP9K1 GO:0016021 1/57 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NP9K1 GO:0070469 1/57 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8BVV7G GO:0006355 6/57 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BVV7G GO:0005634 6/57 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BVV7G GO:0003677 5/57 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BVV7G GO:0003682 3/57 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8S1WP8 GO:0003676 2/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8STVK8 GO:0003677 28/164 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVK8 GO:0004518 27/164 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8STVK8 GO:0008270 2/164 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8STVK8 GO:0004527 1/164 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8STVK8 GO:0016568 1/164 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8STVK8 GO:0005634 1/164 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZPH8Z GO:0016740 24/92 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8ZPH8Z GO:0005524 24/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPH8Z GO:0006955 24/92 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8ZPH8Z GO:0003723 23/92 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8ZPH8Z GO:0000398 1/92 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8ZPH8Z GO:0071013 1/92 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8ZPH8Z GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZPH8Z GO:0045893 1/92 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8ZPH8Z GO:0006351 1/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8ZPH8Z GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZPH8Z GO:0005730 1/92 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8ZPH8Z GO:0071011 1/92 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8ZPH8Z GO:0003725 1/92 double-stranded RNA binding molecular_function "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] EOG8DRCSQ GO:0016021 19/71 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DRCSQ GO:0005743 19/71 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8DRCSQ GO:0005509 3/71 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DRCSQ GO:0005739 1/71 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DRCSQ GO:0022008 1/71 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CG2R0 GO:0008882 2/3 [glutamate-ammonia-ligase] adenylyltransferase activity molecular_function "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42] EOG8CG2R0 GO:0008920 1/3 lipopolysaccharide heptosyltransferase activity molecular_function "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127] EOG8CG2R0 GO:0009103 1/3 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG8CG2R0 GO:0016874 1/3 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8S1WP0 GO:0016491 2/6 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8BVV7S GO:0005525 28/94 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8BVV7S GO:0003924 26/94 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8BVV7S GO:0003746 1/94 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8BVV7S GO:0004222 1/94 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG808QS1 GO:0010181 1/4 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG808QS1 GO:0009055 1/4 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG808QS1 GO:0016491 1/4 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8STVK6 GO:0004871 4/28 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8STVK6 GO:0016020 3/28 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8STVK6 GO:0016021 2/28 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8STVK6 GO:0004888 1/28 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8STVK6 GO:0005506 1/28 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8STVK6 GO:0006935 1/28 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG8STVK6 GO:0020037 1/28 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8STVK6 GO:0009055 1/28 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8STVK6 GO:0005215 1/28 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8CG2R5 GO:0006284 2/9 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8CG2R5 GO:0008725 2/9 DNA-3-methyladenine glycosylase activity molecular_function "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] EOG8CG2R5 GO:0003700 1/9 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CG2R5 GO:0003677 1/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86MDZH GO:0032440 1/40 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG86MDZH GO:0004623 1/40 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG86MDZM GO:0005852 25/90 eukaryotic translation initiation factor 3 complex cellular_component "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] EOG86MDZM GO:0003743 25/90 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG86MDZM GO:0000166 24/90 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86MDZM GO:0016282 23/90 eukaryotic 43S preinitiation complex cellular_component "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] EOG86MDZM GO:0006446 23/90 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG86MDZM GO:0001731 23/90 formation of translation preinitiation complex biological_process "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] EOG86MDZM GO:0033290 23/90 eukaryotic 48S preinitiation complex cellular_component "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] EOG86MDZM GO:0006413 1/90 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG86MDZM GO:0003729 1/90 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG86MDZM GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86MDZM GO:0005829 1/90 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8BVV9F GO:0005634 26/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BVV9F GO:0007317 1/88 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8BVV9F GO:0005515 1/88 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8BVV9F GO:0008103 1/88 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG8BVV9F GO:0006406 1/88 mRNA export from nucleus biological_process "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] EOG8BVV9F GO:0045451 1/88 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8BVV9F GO:0007315 1/88 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8BVV9F GO:0071011 1/88 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8BVV9F GO:0003723 1/88 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BVV9F GO:0048477 1/88 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8BVV9F GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BVV9F GO:0046594 1/88 maintenance of pole plasm mRNA location biological_process "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb] EOG8BVV9F GO:0007173 1/88 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8BVV9F GO:0008104 1/88 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8BVV9F GO:0016325 1/88 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8BVV9F GO:0071013 1/88 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8BVV9F GO:0000398 1/88 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8BVV9F GO:0035145 1/88 exon-exon junction complex cellular_component "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] EOG8BVV9F GO:0045495 1/88 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG8BVV9F GO:0000226 1/88 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8BVV9F GO:0008380 1/88 RNA splicing biological_process "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] EOG8T4GBN GO:0005737 24/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4GBN GO:0005874 24/105 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8T4GBN GO:0003677 1/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N5Z9Z GO:0005634 8/41 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N5Z9Z GO:0006355 8/41 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8N5Z9Z GO:0003723 1/41 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8N5Z9Z GO:0003964 1/41 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8CRPFM GO:0016021 17/50 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPFM GO:0007155 17/50 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8CRPFM GO:0050896 2/50 response to stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] EOG8CRPFM GO:0007608 2/50 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8CRPFM GO:0005886 2/50 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG82JR6P GO:0008233 1/65 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG82JR6P GO:0019783 1/65 ubiquitin-like protein-specific protease activity molecular_function "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] EOG82JR6P GO:0016790 1/65 thiolester hydrolase activity molecular_function "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] EOG8CG2RX GO:0005737 1/83 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CG2RX GO:0022008 1/83 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8S1WPX GO:0046872 2/20 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82JR6N GO:0004197 20/59 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG82JR6N GO:0006915 19/59 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG82JR6N GO:0050829 2/59 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG82JR6N GO:0045087 2/59 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG82JR6N GO:0008656 2/59 cysteine-type endopeptidase activator activity involved in apoptotic process molecular_function "Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis] EOG82JR6N GO:0006919 2/59 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG82JR6N GO:0005737 2/59 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82JR6N GO:0006952 1/59 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG82JR6N GO:0006955 1/59 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG82JR6N GO:0005515 1/59 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82JR6N GO:0061057 1/59 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG82JR6N GO:0006964 1/59 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG82JR6N GO:0043069 1/59 negative regulation of programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG82JR6N GO:0004175 1/59 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG82JR6N GO:0042981 1/59 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG82JR6N GO:0002230 1/59 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG82JR6N GO:0048935 1/59 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG82JR6N GO:0045089 1/59 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG82JR6N GO:0007291 1/59 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG82JR6N GO:0006963 1/59 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG82JR6N GO:0016485 1/59 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8RZ1FH GO:0005272 33/82 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8RZ1FH GO:0016021 27/82 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1FH GO:0016020 6/82 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RZ1FH GO:0005634 2/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RZ1FH GO:0003700 2/82 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86MDZP GO:0000156 4/9 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG86MDZP GO:0000155 1/9 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG86MDZP GO:0016021 1/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86MDZP GO:0005524 1/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86MDZP GO:0006355 1/9 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG808QSW GO:0080019 1/2 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8BK7JX GO:0003700 24/84 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8BK7JX GO:0005634 24/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BK7JX GO:0043565 23/84 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8BK7JX GO:0000976 1/84 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8BK7JX GO:0007417 1/84 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8BK7JX GO:0007419 1/84 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8BK7JX GO:0008134 1/84 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8BK7JX GO:0000122 1/84 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8BK7JX GO:0007420 1/84 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8BK7JX GO:0007400 1/84 neuroblast fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] EOG8BK7JX GO:0009953 1/84 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8BK7JX GO:0010629 1/84 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8BK7JX GO:0007389 1/84 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8BK7JX GO:0007398 1/84 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8BK7JX GO:0006357 1/84 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Z91FN GO:0008270 1/15 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X9B1C GO:0003700 1/17 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X9B1C GO:0008270 1/17 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X9B1C GO:0043565 1/17 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8HTC6F GO:0016021 21/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HTC6F GO:0055085 14/85 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8HTC6F GO:0015114 7/85 phosphate ion transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] EOG8BK7JS GO:0004458 2/6 D-lactate dehydrogenase (cytochrome) activity molecular_function "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] EOG8BK7JS GO:0008762 2/6 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG8BK7JS GO:0050660 2/6 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8H48KQ GO:0003682 1/15 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8HTC6R GO:0016021 33/123 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HTC6R GO:0007155 33/123 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8HTC6R GO:0007608 17/123 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8HTC6R GO:0005886 17/123 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HTC6R GO:0050896 16/123 response to stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] EOG8HTC6R GO:0035073 1/123 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG8HTC6R GO:0019236 1/123 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8HTC6R GO:0055088 1/123 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8HTC6R GO:0043025 1/123 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8HTC6R GO:0030425 1/123 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8HTC6R GO:0007166 1/123 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8BK7JB GO:0003824 3/83 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8ZPHDM GO:0007155 1/2 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8ZPHDM GO:0016021 1/2 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BK7JG GO:0043565 26/95 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8BK7JG GO:0005634 26/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BK7JG GO:0003700 24/95 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8BK7JG GO:0006366 1/95 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8BK7JG GO:0006357 1/95 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8BK7JG GO:0006355 1/95 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BK7JG GO:0045451 1/95 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8BK7JG GO:0010821 1/95 regulation of mitochondrion organization biological_process "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] EOG8BK7JG GO:0000981 1/95 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8FN6XK GO:0005524 23/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FN6XK GO:0004713 20/91 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8FN6XK GO:0007156 4/91 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8FN6XK GO:0005509 4/91 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8FN6XK GO:0005886 3/91 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FN6XK GO:0004714 3/91 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8FN6XK GO:0016020 3/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FN6XK GO:0005887 1/91 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FN6XK GO:0006468 1/91 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8FN6XK GO:0007165 1/91 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8FN6XK GO:0004672 1/91 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8FN6XK GO:0007155 1/91 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8FN6XK GO:0018108 1/91 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8J3ZX3 GO:0016998 22/123 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8J3ZX3 GO:0003824 3/123 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8J3ZX3 GO:0050829 1/123 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8J3ZX3 GO:0005634 1/123 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J3ZX3 GO:0002218 1/123 activation of innate immune response biological_process "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] EOG8J3ZX3 GO:0007476 1/123 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8J3ZX3 GO:0005737 1/123 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W10T8 GO:0016021 27/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82C0Q9 GO:0008061 2/13 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82C0Q9 GO:0005576 2/13 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG82C0Q9 GO:0006030 2/13 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82C0Q6 GO:0003723 31/130 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG82C0Q6 GO:0019013 2/130 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG82C0Q6 GO:0030529 2/130 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG82C0Q6 GO:0004221 2/130 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG82C0Q6 GO:0040040 1/130 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG82C0Q6 GO:0005634 1/130 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82C0Q6 GO:0000381 1/130 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG82C0Q4 GO:0046872 32/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82C0Q4 GO:0003676 30/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0Q4 GO:0016458 2/102 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG82C0Q4 GO:0043565 2/102 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82C0Q4 GO:0005634 2/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82C0Q4 GO:0005515 2/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82C0Q4 GO:0003677 2/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82C0Q4 GO:0005704 1/102 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG82C0Q4 GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0006310 1/102 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG82C0Q4 GO:0010629 1/102 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG82C0Q4 GO:0031011 1/102 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG82C0Q4 GO:0006342 1/102 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG82C0Q4 GO:0048813 1/102 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG82C0Q4 GO:0045892 1/102 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0000980 1/102 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG82C0Q4 GO:0003682 1/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG82C0Q4 GO:0000790 1/102 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG82C0Q4 GO:0048096 1/102 chromatin-mediated maintenance of transcription biological_process "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] EOG82C0Q4 GO:0005703 1/102 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG82C0Q4 GO:0006281 1/102 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG82C0Q4 GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82C0Q4 GO:0006265 1/102 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG82C0Q4 GO:0031490 1/102 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG82C0Q4 GO:0005700 1/102 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8J3ZX9 GO:0007282 1/100 cystoblast division biological_process "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446] EOG8J3ZX9 GO:0035183 1/100 female germline ring canal inner rim cellular_component "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] EOG8J3ZX9 GO:0007411 1/100 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8J3ZX9 GO:0030723 1/100 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8J3ZX9 GO:0048135 1/100 female germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240] EOG8J3ZX9 GO:0045478 1/100 fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] EOG8J3ZX9 GO:0007294 1/100 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8J3ZX9 GO:0005811 1/100 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8J3ZX9 GO:0005737 1/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8J3ZX9 GO:0070050 1/100 neuron cellular homeostasis biological_process "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] EOG8J3ZX9 GO:0008302 1/100 female germline ring canal formation, actin assembly biological_process "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] EOG8J3ZX9 GO:0030721 1/100 spectrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] EOG8J3ZX9 GO:0030724 1/100 testicular fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8J3ZX9 GO:0051297 1/100 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8J3ZX9 GO:0045170 1/100 spectrosome cellular_component "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] EOG8J3ZX9 GO:0000212 1/100 meiotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] EOG8J3ZX9 GO:0045214 1/100 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8J3ZX9 GO:0045172 1/100 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8J3ZX9 GO:0007527 1/100 adult somatic muscle development biological_process "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8J3ZX9 GO:0045169 1/100 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8J3ZX9 GO:0008738 1/100 L-fuculose-phosphate aldolase activity molecular_function "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12936] EOG8J3ZX9 GO:0072499 1/100 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG8J3ZX9 GO:0031987 1/100 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8J3ZX9 GO:0005886 1/100 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8J3ZX9 GO:0005856 1/100 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8J3ZX9 GO:0048134 1/100 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG88KTSH GO:0036054 1/4 protein-malonyllysine demalonylase activity molecular_function "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378] EOG88KTSH GO:0008270 1/4 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88KTSH GO:0034979 1/4 NAD-dependent protein deacetylase activity molecular_function "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah] EOG88KTSH GO:0036055 1/4 protein-succinyllysine desuccinylase activity molecular_function "Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide." [GOC:sp, PMID:22076378] EOG88KTSH GO:0005739 1/4 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG88KTSH GO:0070403 1/4 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG8X99Z2 GO:0005739 26/74 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8X99Z2 GO:0006461 26/74 protein complex assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] EOG82Z74D GO:0004930 9/63 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG82Z74D GO:0016021 7/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82Z74D GO:0006950 7/63 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG82Z74D GO:0016020 1/63 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8577ND GO:0003682 1/114 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8577ND GO:0000793 1/114 condensed chromosome cellular_component "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] EOG8577ND GO:0005085 1/114 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8577ND GO:0005737 1/114 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8577ND GO:0007417 1/114 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8577ND GO:0046822 1/114 regulation of nucleocytoplasmic transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] EOG8577ND GO:0016301 1/114 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8577ND GO:0007346 1/114 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8577ND GO:0005634 1/114 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8577ND GO:0050767 1/114 regulation of neurogenesis biological_process "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] EOG8577ND GO:0007067 1/114 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8577ND GO:0022008 1/114 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8577ND GO:0006607 1/114 NLS-bearing protein import into nucleus biological_process "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] EOG869T7Z GO:0006351 1/8 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG869T7Z GO:0003677 1/8 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG869T7Z GO:0003899 1/8 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG869T7Z GO:0032549 1/8 ribonucleoside binding molecular_function "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] EOG80041M GO:0004950 1/11 chemokine receptor activity molecular_function "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] EOG80041M GO:0006935 1/11 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG80041M GO:0016021 1/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HTC81 GO:0003676 1/11 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HTC81 GO:0046872 1/11 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DJNC1 GO:0007165 25/88 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8DJNC1 GO:0003676 1/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DJNC1 GO:0008270 1/88 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82Z74B GO:0005524 24/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82Z74B GO:0004674 21/82 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG82Z74B GO:0046872 16/82 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82Z74B GO:0035556 16/82 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG82Z74B GO:0004697 3/82 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG82Z74B GO:0004672 1/82 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG82Z74B GO:0006468 1/82 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8HTC84 GO:0046872 3/29 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DJNC5 GO:0016747 1/24 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8SBHD4 GO:0005622 26/77 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8SBHD4 GO:0005215 26/77 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8PCD76 GO:0006334 2/8 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8PCD76 GO:0000786 2/8 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8PCD76 GO:0003677 2/8 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8PCD76 GO:0005634 2/8 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84N15W GO:0008236 24/112 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG84N15W GO:0016020 24/112 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84N15W GO:0006508 3/112 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8577N9 GO:0046080 5/13 dUTP metabolic process biological_process "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] EOG8577N9 GO:0004170 4/13 dUTP diphosphatase activity molecular_function "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] EOG8577N9 GO:0015941 1/13 pantothenate catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] EOG8577N9 GO:0010181 1/13 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8577N9 GO:0004633 1/13 phosphopantothenoylcysteine decarboxylase activity molecular_function "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16796] EOG8577N9 GO:0016787 1/13 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8577N9 GO:0004632 1/13 phosphopantothenate--cysteine ligase activity molecular_function "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] EOG8577N9 GO:0015937 1/13 coenzyme A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] EOG8X99ZM GO:0006229 2/7 dUTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732] EOG8X99ZM GO:0008829 2/7 dCTP deaminase activity molecular_function "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] EOG82C0QN GO:0016746 5/45 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8J3ZXJ GO:0022008 1/94 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8J3ZXJ GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8J3ZXJ GO:0016567 1/94 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8J3ZXJ GO:0051726 1/94 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8J3ZXJ GO:0006950 1/94 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8J3ZXJ GO:0007049 1/94 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8J3ZXJ GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PCD6T GO:0016021 27/65 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG837TX2 GO:0004180 1/51 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG837TX2 GO:0005615 1/51 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG837TX2 GO:0006952 1/51 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG837TX2 GO:0032504 1/51 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8T4GC3 GO:0042981 5/15 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG85MQM7 GO:0005057 25/93 receptor signaling protein activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] EOG85MQM7 GO:0005524 25/93 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85MQM7 GO:0004674 25/93 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG85MQM7 GO:0046872 24/93 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85MQM7 GO:0008284 1/93 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG85MQM7 GO:0008069 1/93 dorsal/ventral axis specification, ovarian follicular epithelium biological_process "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG85MQM7 GO:0007476 1/93 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG85MQM7 GO:0009267 1/93 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG85MQM7 GO:0007173 1/93 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG85MQM7 GO:0046534 1/93 positive regulation of photoreceptor cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] EOG85MQM7 GO:0008293 1/93 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG85MQM7 GO:0008586 1/93 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG85MQM7 GO:0007283 1/93 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG85MQM7 GO:0035309 1/93 wing and notum subfield formation biological_process "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] EOG85MQM7 GO:0051726 1/93 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG85MQM7 GO:0004715 1/93 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG85MQM7 GO:0007362 1/93 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG85MQM7 GO:0030097 1/93 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG85MQM7 GO:0016772 1/93 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG85MQM7 GO:0046777 1/93 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG85MQM7 GO:0016242 1/93 negative regulation of macroautophagy biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] EOG85MQM7 GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85MQM7 GO:0007369 1/93 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG85MQM7 GO:2001234 1/93 negative regulation of apoptotic signaling pathway biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] EOG85MQM7 GO:0007298 1/93 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG85MQM7 GO:0002168 1/93 instar larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG85MQM7 GO:0007472 1/93 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG85MQM7 GO:0007552 1/93 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG85MQM7 GO:0007428 1/93 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG85MQM7 GO:0040014 1/93 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG85MQM7 GO:0042386 1/93 hemocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] EOG85MQM7 GO:0035171 1/93 lamellocyte differentiation biological_process "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] EOG85MQM7 GO:0007165 1/93 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8ZSCHF GO:0008305 3/8 integrin complex cellular_component "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] EOG8ZSCHF GO:0007155 3/8 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8ZSCHF GO:0007229 3/8 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8VDSFF GO:0016020 35/2018 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VDSFF GO:0051781 22/2018 positive regulation of cell division biological_process "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] EOG8VDSFF GO:0007435 2/2018 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8VDSFF GO:0035099 2/2018 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8VDSFF GO:0003964 1/2018 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VDSFF GO:0008039 1/2018 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8VDSFF GO:0035172 1/2018 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8XKXQ1 GO:0003677 2/3 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XKXQ1 GO:0006281 2/3 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8XKXQ1 GO:0003887 2/3 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8XKXQ1 GO:0003912 2/3 DNA nucleotidylexotransferase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] EOG8B2WDC GO:0003677 3/350 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B2WDC GO:0004518 2/350 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8B2WDC GO:0016747 1/350 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8B2WDC GO:0004527 1/350 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8PCD6R GO:0020037 19/73 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8PCD6R GO:0005506 17/73 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8PCD6R GO:0006633 17/73 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8PCD6R GO:0016491 15/73 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8PCD6R GO:0005783 13/73 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8PCD6R GO:0006665 13/73 sphingolipid metabolic process biological_process "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8PCD6R GO:0016021 2/73 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PCD6R GO:0046872 2/73 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PCD6R GO:0006979 1/73 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8PCD6R GO:0052722 1/73 fatty acid in-chain hydroxylase activity molecular_function "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186] EOG8PCD6R GO:0004601 1/73 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG8PCD6R GO:0003676 1/73 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84TRNW GO:0003950 23/103 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG84TRNW GO:0006471 23/103 protein ADP-ribosylation biological_process "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] EOG84TRNW GO:0003677 21/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84TRNW GO:0008270 21/103 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84TRNW GO:0051287 20/103 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG84TRNW GO:0005634 20/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84TRNW GO:0042393 1/103 histone binding molecular_function "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] EOG84TRNW GO:0035080 1/103 heat shock-mediated polytene chromosome puffing biological_process "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] EOG84TRNW GO:0007000 1/103 nucleolus organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] EOG84TRNW GO:0048812 1/103 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG84TRNW GO:0005700 1/103 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG84TRNW GO:0030576 1/103 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG84TRNW GO:0043484 1/103 regulation of RNA splicing biological_process "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] EOG84TRNW GO:0035363 1/103 histone locus body cellular_component "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] EOG84TRNW GO:0005719 1/103 nuclear euchromatin cellular_component "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] EOG84TRNW GO:0016568 1/103 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG84TRNW GO:0051457 1/103 maintenance of protein location in nucleus biological_process "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] EOG84TRNW GO:0006963 1/103 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG84TRNW GO:0005703 1/103 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG84TRNW GO:0035079 1/103 polytene chromosome puffing biological_process "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] EOG84TRNW GO:0015030 1/103 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG84TRNW GO:0009303 1/103 rRNA transcription biological_process "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] EOG84TRNW GO:0006355 1/103 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84TRNW GO:0005730 1/103 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG84TRNW GO:0045087 1/103 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG84TRNW GO:0007552 1/103 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG84TRNW GO:0051276 1/103 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG84TRNW GO:0005694 1/103 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8QZB14 GO:0051438 1/91 regulation of ubiquitin-protein transferase activity biological_process "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] EOG8QZB14 GO:0032440 1/91 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8QZB14 GO:0004842 1/91 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8CZDW7 GO:0016491 3/7 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8ZSCHT GO:0008270 19/78 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80S2WH GO:0050660 4/11 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG80S2WH GO:0006744 4/11 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG80S2WH GO:0016709 3/11 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG80S2WH GO:0004502 1/11 kynurenine 3-monooxygenase activity molecular_function "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20548] EOG80S2WH GO:0008681 1/11 2-octaprenyl-6-methoxyphenol hydroxylase activity molecular_function "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN] EOG8ZSCHP GO:0003676 128/391 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZSCHP GO:0005634 126/391 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZSCHP GO:0008270 126/391 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZSCHP GO:0046872 28/391 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZSCHP GO:0005739 24/391 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8ZSCHP GO:0003677 23/391 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZSCHP GO:0005840 3/391 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8ZSCHP GO:0007349 1/391 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8ZSCHP GO:0045143 1/391 homologous chromosome segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] EOG8ZSCHP GO:0007143 1/391 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8ZSCHP GO:0007279 1/391 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8ZSCHP GO:0006366 1/391 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8ZSCHP GO:0006357 1/391 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8ZSCHP GO:0007343 1/391 egg activation biological_process "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] EOG8ZSCHP GO:0000987 1/391 core promoter proximal region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8ZSCHP GO:0045944 1/391 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8CZDW1 GO:0000166 44/126 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CZDW1 GO:0003723 30/126 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CZDW1 GO:0003676 13/126 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CZDW1 GO:0003729 2/126 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8CZDW1 GO:0008143 2/126 poly(A) binding molecular_function "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] EOG8CZDW1 GO:0048477 1/126 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8CZDW1 GO:1901215 1/126 negative regulation of neuron death biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] EOG8CZDW1 GO:0007268 1/126 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8CZDW1 GO:0007112 1/126 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8CZDW1 GO:0009953 1/126 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8CZDW1 GO:0071011 1/126 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CZDW1 GO:0007140 1/126 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8CZDW1 GO:0005875 1/126 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8CZDW1 GO:0005515 1/126 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CZDW1 GO:0045727 1/126 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG8CZDW1 GO:0030529 1/126 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8CZDW1 GO:0016491 1/126 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8CZDW1 GO:0048599 1/126 oocyte development biological_process "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] EOG8CZDW1 GO:0022008 1/126 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CZDW1 GO:0007283 1/126 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8CZDW1 GO:0007289 1/126 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG8CZDW1 GO:0071013 1/126 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8CZDW1 GO:0000398 1/126 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CZDW1 GO:0003730 1/126 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8CZDW1 GO:0005811 1/126 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8CZDW1 GO:0045314 1/126 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG8CZDW1 GO:0005737 1/126 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80S2WC GO:0006629 148/439 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG80S2WC GO:0005576 148/439 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80S2WC GO:0008970 88/439 phosphatidylcholine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] EOG80S2WC GO:0016787 52/439 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80S2WC GO:0052739 12/439 phosphatidylserine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034] EOG80S2WC GO:0052740 12/439 1-acyl-2-lysophosphatidylserine acylhydrolase activity molecular_function "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] EOG80S2WC GO:0004806 11/439 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG80S2WC GO:0003824 3/439 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG80S2WC GO:0003676 1/439 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80S2WC GO:0008270 1/439 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80S2WC GO:0022008 1/439 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG851H7H GO:0003700 1/7 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8QZB1M GO:0004767 5/118 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8QZB1M GO:0016787 4/118 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZSCH2 GO:0003824 22/95 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8ZSCH2 GO:0003833 1/95 beta-alanyl-dopamine synthase activity molecular_function "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543] EOG8ZSCH2 GO:0006583 1/95 melanin biosynthetic process from tyrosine biological_process "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] EOG8ZSCH2 GO:0016874 1/95 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8ZSCH2 GO:0045475 1/95 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8ZSCH2 GO:0048022 1/95 negative regulation of melanin biosynthetic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] EOG8ZSCH2 GO:0042417 1/95 dopamine metabolic process biological_process "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] EOG8ZSCH2 GO:0043042 1/95 amino acid adenylylation by nonribosomal peptide synthase biological_process "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910] EOG8ZSCH2 GO:0048082 1/95 regulation of adult chitin-containing cuticle pigmentation biological_process "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] EOG8ZSCH2 GO:0047462 1/95 phenylalanine racemase (ATP-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20204] EOG8ZSCH2 GO:0048066 1/95 developmental pigmentation biological_process "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] EOG8ZSCH2 GO:0048067 1/95 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG8ZSCH2 GO:0001692 1/95 histamine metabolic process biological_process "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] EOG8ZSCH2 GO:0007623 1/95 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8ZSCH2 GO:0005737 1/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZSCH2 GO:0007593 1/95 chitin-based cuticle sclerotization biological_process "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu] EOG8ZSCH2 GO:0042440 1/95 pigment metabolic process biological_process "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] EOG8VDSF8 GO:0003676 3/73 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSF8 GO:0004526 3/73 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8VDSF8 GO:0008033 3/73 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8VDSF8 GO:0005634 3/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VDSF8 GO:0016021 1/73 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZSCH8 GO:0008270 38/129 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZSCH8 GO:0048749 1/129 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8ZSCH8 GO:0019100 1/129 male germ-line sex determination biological_process "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] EOG8ZSCH8 GO:0042393 1/129 histone binding molecular_function "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] EOG8ZSCH8 GO:0005700 1/129 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8ZSCH8 GO:0022008 1/129 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8ZSCH8 GO:0046872 1/129 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85MQMN GO:0070461 22/90 SAGA-type complex cellular_component "A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012] EOG85MQMN GO:0005634 2/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85MQMN GO:0000124 2/90 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG8QRKMV GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QRKMV GO:0055085 1/7 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8QRKMV GO:0003700 1/7 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8QRKMQ GO:0055114 1/70 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG837TXH GO:0005576 6/76 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG837TXH GO:0008061 6/76 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0006030 6/76 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0005201 1/76 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG837TXH GO:0031012 1/76 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG837TXH GO:0005581 1/76 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG85MQMR GO:0003854 25/64 3-beta-hydroxy-delta5-steroid dehydrogenase activity molecular_function "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145] EOG85MQMR GO:0006694 25/64 steroid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] EOG85MQMR GO:0008460 15/64 dTDP-glucose 4,6-dehydratase activity molecular_function "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224] EOG85MQMR GO:0009225 15/64 nucleotide-sugar metabolic process biological_process "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] EOG85MQMR GO:0004769 3/64 steroid delta-isomerase activity molecular_function "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] EOG85MQMR GO:0050662 1/64 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG85MQMR GO:0045552 1/64 dihydrokaempferol 4-reductase activity molecular_function "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] EOG85MQMR GO:0044237 1/64 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8616K8 GO:0016021 29/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616K8 GO:0055085 28/137 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8616K8 GO:0015293 1/137 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8616K8 GO:0006816 1/137 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0008273 1/137 calcium, potassium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] EOG8616K8 GO:0035725 1/137 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8616K8 GO:0006814 1/137 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0048749 1/137 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8616K8 GO:0048812 1/137 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8G1PZ1 GO:0015074 13/60 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8G1PZ1 GO:0003676 13/60 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G1PZ1 GO:0005634 2/60 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CJXWZ GO:0016829 1/15 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8CJXWZ GO:0016021 1/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXWZ GO:0022857 1/15 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8CJXWZ GO:0003924 1/15 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8CJXWZ GO:0005525 1/15 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8616K3 GO:0005737 26/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8616K3 GO:0016149 26/108 translation release factor activity, codon specific molecular_function "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] EOG8616K3 GO:0003747 1/108 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG8M3CPP GO:0004066 31/97 asparagine synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] EOG8M3CPP GO:0070981 27/97 L-asparagine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] EOG8M3CPP GO:0005524 27/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CPP GO:0006529 4/97 asparagine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] EOG8M3CPP GO:0008152 1/97 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8M3CQ3 GO:0000287 27/92 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8M3CQ3 GO:0051287 27/92 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8M3CQ3 GO:0004449 25/92 isocitrate dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] EOG8M3CQ3 GO:0006099 24/92 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8M3CQ3 GO:0016616 2/92 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8M3CQ3 GO:0005524 1/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CQ3 GO:0004674 1/92 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8M3CQ3 GO:0005875 1/92 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8M3CPK GO:0003678 9/67 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8M3CPK GO:0000723 9/67 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8M3CPK GO:0006281 9/67 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8M3CPK GO:0004386 3/67 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8M3CPK GO:0005524 3/67 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CPK GO:0003676 1/67 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M3CPK GO:0006511 1/67 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG84BDH4 GO:0005737 4/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84BDH4 GO:0007620 4/100 copulation biological_process "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] EOG84BDH4 GO:0007610 3/100 behavior biological_process "The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] EOG84BDH4 GO:0046426 1/100 negative regulation of JAK-STAT cascade biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG84BDH4 GO:0045893 1/100 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84BDH4 GO:0045571 1/100 negative regulation of imaginal disc growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] EOG84BDH4 GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84BDH4 GO:0000932 1/100 cytoplasmic mRNA processing body cellular_component "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] EOG84BDH4 GO:0060179 1/100 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8HQGZD GO:0003755 1/39 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8HQGZD GO:0006457 1/39 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG87M4BT GO:0003677 24/98 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87M4BT GO:0008138 22/98 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG87M4BT GO:0004725 22/98 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG87M4BT GO:0006470 1/98 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG87M4BT GO:0007409 1/98 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG87M4BT GO:0040023 1/98 establishment of nucleus localization biological_process "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] EOG87M4BT GO:0030837 1/98 negative regulation of actin filament polymerization biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] EOG87M4BT GO:0008064 1/98 regulation of actin polymerization or depolymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] EOG87M4BT GO:0003779 1/98 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG87M4BT GO:0050770 1/98 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG87M4BT GO:0030833 1/98 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG87M4BT GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87M4BT GO:0048749 1/98 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG87M4BT GO:0045177 1/98 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG87M4BT GO:0005856 1/98 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG87M4BT GO:0000278 1/98 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG87M4BT GO:0004721 1/98 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG87M4BT GO:0000902 1/98 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG87M4BT GO:0016319 1/98 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG87M4BT GO:0010591 1/98 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG834ZQ6 GO:0004252 2/6 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG87M4BV GO:0046872 25/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG87M4BV GO:0003723 1/87 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87M4BV GO:0003676 1/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87M4BV GO:0008270 1/87 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87M4BV GO:0005654 1/87 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG87M4BV GO:0005700 1/87 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG87M4BV GO:0071027 1/87 nuclear RNA surveillance biological_process "The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] EOG87M4BV GO:0045892 1/87 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8M3CPB GO:0019230 1/19 proprioception biological_process "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X] EOG8M3CPB GO:0071683 1/19 sensory dendrite cellular_component "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] EOG8M3CPB GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M3CPB GO:0042330 1/19 taxis biological_process "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] EOG81NX1F GO:0002009 1/84 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG81NX1F GO:0007507 1/84 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG81NX1F GO:0005578 1/84 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG81NX1F GO:0061343 1/84 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG81NX1F GO:0007508 1/84 larval heart development biological_process "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238] EOG81NX1D GO:0003676 1/92 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81NX1D GO:0046872 1/92 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG841SSW GO:0004550 8/37 nucleoside diphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] EOG841SSW GO:0006241 8/37 CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG841SSW GO:0006228 8/37 UTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] EOG841SSW GO:0006183 8/37 GTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] EOG841SSW GO:0005524 8/37 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81NX1M GO:0008270 22/81 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81NX1M GO:0009056 22/81 catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] EOG81NX1M GO:0016788 14/81 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8F4VTB GO:0005634 2/17 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F4VTB GO:0003713 2/17 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG80GG6F GO:0015031 26/91 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG80GG6F GO:0016020 26/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80GG6F GO:0006886 1/91 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG80GG6F GO:0016491 1/91 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80GG6F GO:0019028 1/91 viral capsid cellular_component "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] EOG80GG6F GO:0010883 1/91 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG80GG6F GO:0030117 1/91 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG80GG6F GO:0016192 1/91 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG80GG6F GO:0006909 1/91 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8DJN99 GO:0005524 1/16 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DJN99 GO:0003824 1/16 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8DJN99 GO:0046872 1/16 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DJN99 GO:0006807 1/16 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG8WWTZT GO:0003676 15/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WWTZT GO:0046872 15/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WWTZT GO:0005634 14/21 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WWTZT GO:0007265 1/21 Ras protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] EOG8WWTZT GO:0007474 1/21 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8F4VTV GO:0042302 14/46 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG80GG6J GO:0042048 1/84 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8Q5C37 GO:0016772 6/109 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Q5C37 GO:0004672 1/109 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8Q5C37 GO:0016905 1/109 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG8Q5C37 GO:0005524 1/109 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80GG67 GO:0006950 2/58 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG80GG67 GO:0046872 1/58 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80GG67 GO:0020037 1/58 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8HQGZK GO:0005737 1/14 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HQGZK GO:0006433 1/14 prolyl-tRNA aminoacylation biological_process "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] EOG8HQGZK GO:0004827 1/14 proline-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] EOG8HQGZK GO:0005524 1/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80GG60 GO:0005975 1/9 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG80GG60 GO:0016853 1/9 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG80GG60 GO:0030554 1/9 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG80GG60 GO:0030246 1/9 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG81NX16 GO:0006511 5/12 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG81NX16 GO:0004843 4/12 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG81NX11 GO:0003700 24/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81NX11 GO:0005667 24/88 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG81NX11 GO:0005634 24/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81NX11 GO:0004871 24/88 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG81NX11 GO:0005737 24/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81NX11 GO:0003677 24/88 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81NX11 GO:0006351 24/88 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG81NX11 GO:0046982 1/88 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG81NX11 GO:0008062 1/88 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG81NX11 GO:0007622 1/88 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG81NX11 GO:0032922 1/88 circadian regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] EOG81NX11 GO:0045475 1/88 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG81NX11 GO:0045187 1/88 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG81NX11 GO:0005515 1/88 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81NX11 GO:0048148 1/88 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG81NX11 GO:0042594 1/88 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG81NX11 GO:0000122 1/88 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG81NX11 GO:0045944 1/88 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG81NX11 GO:0007623 1/88 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG81NX11 GO:0045893 1/88 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Q5C3S GO:0052689 2/72 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8Q5C3S GO:0034736 1/72 cholesterol O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [EC:2.3.1.26, RHEA:17732] EOG8Q5C3P GO:0005525 26/93 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8Q5C3P GO:0003924 2/93 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8Q5C3P GO:0042273 1/93 ribosomal large subunit biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] EOG8Q5C3P GO:0006254 1/93 CTP catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG8Q5C3P GO:0006200 1/93 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8Q5C3P GO:0090070 1/93 positive regulation of ribosome biogenesis biological_process "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] EOG8Q5C3P GO:0007431 1/93 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8Q5C3P GO:0001652 1/93 granular component cellular_component "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] EOG8Q5C3P GO:0048588 1/93 developmental cell growth biological_process "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] EOG8Q5C3P GO:0042254 1/93 ribosome biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] EOG8Q5C3P GO:0042127 1/93 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8Q5C3P GO:0005730 1/93 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8Q5C3P GO:0016887 1/93 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8Q5C3P GO:0006184 1/93 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8Q5C3P GO:0046626 1/93 regulation of insulin receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8Q5C3P GO:0043273 1/93 CTPase activity molecular_function "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] EOG8Q5C3P GO:0040014 1/93 regulation of multicellular organism growth biological_process "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] EOG8Q5C3P GO:0007494 1/93 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8Q5C3P GO:0046052 1/93 UTP catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators] EOG8WWTZ9 GO:0004674 7/40 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8WWTZ9 GO:0005524 7/40 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D2954 GO:0031409 13/31 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8D2954 GO:0006979 1/31 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8D2954 GO:0008340 1/31 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8D2954 GO:0070328 1/31 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8D2954 GO:0033500 1/31 carbohydrate homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] EOG8D2954 GO:0005615 1/31 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8D2954 GO:0005215 1/31 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8D2954 GO:0008289 1/31 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8D2954 GO:0032504 1/31 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8616KS GO:0030170 25/130 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8616KS GO:0003824 25/130 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8616KS GO:0030151 25/130 molybdenum ion binding molecular_function "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] EOG83N9VW GO:0005634 95/339 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83N9VW GO:0003700 95/339 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG83N9VW GO:0043565 89/339 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83N9VW GO:0019101 1/339 female somatic sex determination biological_process "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] EOG83N9VW GO:0000398 1/339 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG83N9VW GO:0003677 1/339 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83N9VW GO:0007548 1/339 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG83N9VW GO:0045497 1/339 female analia development biological_process "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0001078 1/339 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG83N9VW GO:0008049 1/339 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG83N9VW GO:0045892 1/339 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046661 1/339 male sex differentiation biological_process "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0048086 1/339 negative regulation of developmental pigmentation biological_process "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] EOG83N9VW GO:0045433 1/339 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG83N9VW GO:0018993 1/339 somatic sex determination biological_process "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] EOG83N9VW GO:0006355 1/339 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0042803 1/339 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG83N9VW GO:0045893 1/339 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0048071 1/339 sex-specific pigmentation biological_process "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] EOG83N9VW GO:0045496 1/339 male analia development biological_process "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0007619 1/339 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83N9VW GO:0007283 1/339 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG83N9VW GO:0007417 1/339 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG83N9VW GO:0016199 1/339 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG83N9VW GO:0035215 1/339 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG83N9VW GO:0045944 1/339 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046872 1/339 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83N9VW GO:0003729 1/339 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG83N9VW GO:0045498 1/339 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG83N9VW GO:0005515 1/339 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83N9VW GO:0000122 1/339 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0007483 1/339 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG83N9VW GO:0001077 1/339 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG83N9VW GO:0007530 1/339 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG83N9VW GO:0007486 1/339 imaginal disc-derived female genitalia development biological_process "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0006357 1/339 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0019102 1/339 male somatic sex determination biological_process "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] EOG83N9VW GO:0007485 1/339 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0035263 1/339 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG83N9VW GO:0046660 1/339 female sex differentiation biological_process "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0045570 1/339 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG8HQGZS GO:0005634 12/74 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HQGZS GO:0046872 10/74 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HQGZS GO:0004535 10/74 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG8HQGZS GO:0003723 10/74 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HQGZS GO:0000166 10/74 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8HQGZS GO:0005737 10/74 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HQGZS GO:0006402 10/74 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG8HQGZS GO:0003676 2/74 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83N9VN GO:0003676 1/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG805VHN GO:0005856 1/5 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG84BDHT GO:0016791 4/14 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG83N9VC GO:0035556 3/44 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8HMMT0 GO:0008076 53/210 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8HMMT0 GO:0005249 52/210 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8HMMT0 GO:0051260 48/210 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8HMMT0 GO:0005251 2/210 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8HMMT0 GO:0004114 2/210 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG8HMMT0 GO:0030431 1/210 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8HMMT0 GO:0046872 1/210 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HMMT0 GO:0006813 1/210 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8HMMT0 GO:0005886 1/210 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8TTK14 GO:0033743 30/101 peptide-methionine (R)-S-oxide reductase activity molecular_function "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24167] EOG8TTK14 GO:0006979 30/101 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8TTK14 GO:0030091 30/101 protein repair biological_process "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] EOG8TTK14 GO:0008113 2/101 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG8TTK14 GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTK14 GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TTK14 GO:0008270 1/101 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82VBX4 GO:0005524 2/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG82VBX4 GO:0016887 1/8 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG82VBX4 GO:0030254 1/8 protein secretion by the type III secretion system biological_process "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] EOG82VBX4 GO:0009058 1/8 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG82VBX4 GO:0030257 1/8 type III protein secretion system complex cellular_component "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] EOG82VBX4 GO:0005737 1/8 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K3PC8 GO:0016021 1/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K3PC8 GO:0006810 1/3 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8S1WQM GO:0005634 12/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WQM GO:0003700 12/62 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8K3PC5 GO:0015074 10/59 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8K3PC5 GO:0003676 9/59 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K3PC5 GO:0004190 5/59 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8K3PC5 GO:0003964 5/59 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8K3PC5 GO:0003723 5/59 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D55DR GO:0003824 2/7 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8RFP8G GO:0016881 28/93 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8RFP8G GO:0004842 4/93 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8RFP8G GO:0060074 1/93 synapse maturation biological_process "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef] EOG8RFP8G GO:0045977 1/93 positive regulation of mitotic cell cycle, embryonic biological_process "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8RFP8G GO:0031625 1/93 ubiquitin protein ligase binding molecular_function "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] EOG8RFP8G GO:0005524 1/93 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RFP8G GO:0035370 1/93 UBC13-UEV1A complex cellular_component "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784] EOG8RFP8G GO:0007412 1/93 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8RFP8G GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RFP8G GO:0072347 1/93 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG8RFP8G GO:0005634 1/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RFP8G GO:0007625 1/93 grooming behavior biological_process "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] EOG8RFP8G GO:0007629 1/93 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8RFP8G GO:0007409 1/93 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8RFP8G GO:0008594 1/93 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8RFP8G GO:0007630 1/93 jump response biological_process "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] EOG8RFP8G GO:0051124 1/93 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8RFP8G GO:0048471 1/93 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG808QPP GO:0030170 18/93 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG808QPP GO:0009058 17/93 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG808QPP GO:0003824 13/93 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG808QPP GO:0008483 4/93 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG808QPP GO:0047536 1/93 2-aminoadipate transaminase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12604] EOG808QPP GO:0003700 1/93 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8KH588 GO:0007476 1/85 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8VMHW8 GO:0016491 24/87 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8VMHW8 GO:0005778 2/87 peroxisomal membrane cellular_component "The lipid bilayer surrounding a peroxisome." [GOC:mah] EOG8VMHW8 GO:0016021 2/87 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VMHW8 GO:0070524 1/87 11-beta-hydroxysteroid dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] EOG8VMHW8 GO:0004316 1/87 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8GQSN0 GO:0005524 5/13 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GQSN0 GO:0006260 5/13 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8GQSN0 GO:0004797 5/13 thymidine kinase activity molecular_function "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] EOG8HTC7P GO:0050662 2/4 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8HTC7P GO:0044237 2/4 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8HTC7P GO:0003824 1/4 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8HTC7P GO:0003978 1/4 UDP-glucose 4-epimerase activity molecular_function "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] EOG8H48JF GO:0016987 1/14 sigma factor activity molecular_function "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH] EOG8H48JF GO:0003677 1/14 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H48JF GO:0006352 1/14 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG8H48JF GO:0003700 1/14 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8VMHW4 GO:0006004 34/108 fucose metabolic process biological_process "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] EOG8VMHW4 GO:0004560 34/108 alpha-L-fucosidase activity molecular_function "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] EOG8VMHW4 GO:0042742 1/108 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8VMHW4 GO:0005737 1/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VMHW4 GO:0004725 1/108 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8VMHW4 GO:0005764 1/108 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8VMHW4 GO:0042806 1/108 fucose binding molecular_function "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [CHEBI:33984, ISBN:0582227089] EOG8VMHW4 GO:0006027 1/108 glycosaminoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] EOG8ZGRS6 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZGRS6 GO:0008026 1/6 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8ZGRS6 GO:0003676 1/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KH58N GO:0030170 27/92 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8KH58N GO:0006564 24/92 L-serine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] EOG8KH58N GO:0004648 24/92 O-phospho-L-serine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] EOG8KH58N GO:0008483 3/92 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8H48J8 GO:0009360 2/10 DNA polymerase III complex cellular_component "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710] EOG8H48J8 GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H48J8 GO:0003677 2/10 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H48J8 GO:0017111 2/10 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8H48J8 GO:0003887 2/10 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8HTC77 GO:0003676 1/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RFP80 GO:0007165 23/106 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8RFP80 GO:0046847 23/106 filopodium assembly biological_process "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] EOG8RFP80 GO:0005524 1/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RFP80 GO:0042803 1/106 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8RFP80 GO:0017124 1/106 SH3 domain binding molecular_function "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] EOG8RFP80 GO:0005543 1/106 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8RFP80 GO:0008354 1/106 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8RFP80 GO:0048261 1/106 negative regulation of receptor-mediated endocytosis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators] EOG8RFP80 GO:0043234 1/106 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8RFP80 GO:0007298 1/106 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8RFP80 GO:0004363 1/106 glutathione synthase activity molecular_function "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560] EOG8TTK1P GO:0016757 2/68 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8V9X6N GO:0009058 3/18 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8V9X6N GO:0003824 3/18 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8RZ1G1 GO:0006631 3/6 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG8RZ1G1 GO:0003857 3/6 3-hydroxyacyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] EOG8RZ1G1 GO:0008270 3/6 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QFZZ0 GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QFZZ0 GO:0005215 1/4 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8BVV80 GO:0005509 1/68 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8323F8 GO:0016020 1/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BVV83 GO:0009166 125/386 nucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG8BVV83 GO:0046872 81/386 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BVV83 GO:0000166 80/386 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8BVV83 GO:0016788 75/386 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8BVV83 GO:0016787 38/386 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BVV83 GO:0008253 12/386 5'-nucleotidase activity molecular_function "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] EOG8BVV83 GO:0016311 2/386 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8BVV83 GO:0017110 1/386 nucleoside-diphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] EOG8BVV83 GO:0005524 1/386 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BVV83 GO:0017111 1/386 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8BVV83 GO:0005576 1/386 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BVV83 GO:0045134 1/386 uridine-diphosphatase activity molecular_function "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] EOG8S1WQ3 GO:0005875 1/103 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8S1WQ3 GO:0070201 1/103 regulation of establishment of protein localization biological_process "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] EOG8S1WQ3 GO:0060811 1/103 intracellular mRNA localization involved in anterior/posterior axis specification biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] EOG8S1WQ3 GO:0005854 1/103 nascent polypeptide-associated complex cellular_component "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] EOG8S1WQ3 GO:0007317 1/103 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG808QP5 GO:0005215 34/99 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG808QP5 GO:0055085 34/99 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG808QP5 GO:0016020 31/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG808QP5 GO:0016021 3/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG808QP5 GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG808QP5 GO:0008270 1/99 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG808QP5 GO:0003676 1/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z0DKG GO:0000139 2/123 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8Z0DKG GO:0009967 2/123 positive regulation of signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] EOG8Z0DKG GO:0019901 2/123 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG8Z0DKG GO:0005078 2/123 MAP-kinase scaffold activity molecular_function "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] EOG8Z0DKG GO:0008088 2/123 axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] EOG8Z0DKG GO:0046328 2/123 regulation of JNK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8Z0DKG GO:0016192 2/123 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8Z0DKG GO:0019894 2/123 kinesin binding molecular_function "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] EOG8Z0DKG GO:0030140 2/123 trans-Golgi network transport vesicle cellular_component "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] EOG8Z0DKG GO:0016301 1/123 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8Z0DKF GO:0005634 22/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z0DKF GO:0003677 22/93 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Z0DKF GO:0005700 1/93 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8Z0DKF GO:0035098 1/93 ESC/E(Z) complex cellular_component "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] EOG8Z0DKF GO:0061085 1/93 regulation of histone H3-K27 methylation biological_process "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] EOG8Z0DKF GO:0005719 1/93 nuclear euchromatin cellular_component "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] EOG8Z0DKK GO:0008270 25/96 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z0DKK GO:0004842 25/96 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8Z0DKK GO:0005737 1/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z0DKK GO:0048471 1/96 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8Z0DKK GO:0070923 1/96 siRNA loading onto RISC involved in chromatin silencing by small RNA biological_process "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] EOG8Z0DKK GO:0060966 1/96 regulation of gene silencing by RNA biological_process "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] EOG8Z0DKM GO:0033314 1/83 mitotic DNA replication checkpoint biological_process "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] EOG8Z0DKM GO:0005634 1/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DNHKN GO:0008168 15/61 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8Z0DKX GO:0000166 23/99 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8Z0DKX GO:0006397 23/99 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8Z0DKX GO:0003676 23/99 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z0DKX GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z0DKX GO:0000398 1/99 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8Z0DKX GO:0003729 1/99 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8Z0DKX GO:0071011 1/99 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8Z0DKX GO:0000381 1/99 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8Z0DKZ GO:0006535 28/108 cysteine biosynthetic process from serine biological_process "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] EOG8Z0DKZ GO:0004122 26/108 cystathionine beta-synthase activity molecular_function "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] EOG8Z0DKZ GO:0005737 24/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z0DKZ GO:0019343 24/108 cysteine biosynthetic process via cystathionine biological_process "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] EOG8Z0DKZ GO:0030554 21/108 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8Z0DKZ GO:0046872 1/108 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Z0DKZ GO:0008340 1/108 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8FXTRF GO:0003723 1/14 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FXTRF GO:0003676 1/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FXTRF GO:0003964 1/14 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VHNN9 GO:0004252 4/37 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG84N16Z GO:0003677 1/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84N16Z GO:0009360 1/4 DNA polymerase III complex cellular_component "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710] EOG84N16Z GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84N16Z GO:0003887 1/4 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG84N16Z GO:0017111 1/4 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG82C0RB GO:0003676 26/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0RB GO:0004527 25/100 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8SN44K GO:0005700 1/82 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8SN44K GO:0005737 1/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SN44K GO:0048812 1/82 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8SN44K GO:0005634 1/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JHFWR GO:0005615 2/9 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8SN44B GO:0005737 1/8 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SN44B GO:0000105 1/8 histidine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] EOG8SN44B GO:0000107 1/8 imidazoleglycerol-phosphate synthase activity molecular_function "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN] EOG8G1PWS GO:0005524 1/18 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G1PWS GO:0051301 1/18 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8G1PWS GO:0007049 1/18 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8G1PWS GO:0042597 1/18 periplasmic space cellular_component "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] EOG8G1PWS GO:0007059 1/18 chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] EOG8G1PWS GO:0003677 1/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8G1PWS GO:0016021 1/18 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G1PWS GO:0042954 1/18 lipoprotein transporter activity molecular_function "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732] EOG841SRP GO:0003677 15/58 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG841SRP GO:0003682 1/58 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG841SRP GO:0046331 1/58 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG841SRP GO:0048813 1/58 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG841SRP GO:0005524 1/58 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G1PWP GO:0016021 83/226 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G1PWP GO:0055085 83/226 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8G1PWP GO:0008643 1/226 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8G1PWP GO:0046872 1/226 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8577RJ GO:0005272 1/2 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8577RJ GO:0016021 1/2 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RBT1D GO:0006030 9/26 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8RBT1D GO:0005576 9/26 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RBT1D GO:0008061 9/26 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG89627Q GO:0015074 1/12 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG89627Q GO:0003676 1/12 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89627Q GO:0008270 1/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X3KKZ GO:0030170 1/3 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8X3KKZ GO:0006520 1/3 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8X3KKZ GO:0016829 1/3 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8RBT1M GO:0005634 84/201 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RBT1M GO:0006351 83/201 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8RBT1M GO:0003677 79/201 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RBT1M GO:0006355 79/201 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RBT1M GO:0003700 5/201 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RBT1M GO:0048749 5/201 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8RBT1M GO:0043565 5/201 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RBT1M GO:0007219 4/201 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8RBT1M GO:0000122 4/201 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RBT1M GO:0005515 2/201 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RBT1M GO:0008134 2/201 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8RBT1M GO:0030154 2/201 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8RBT1M GO:0007399 2/201 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8RBT1M GO:0048666 1/201 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8RBT1M GO:0002052 1/201 positive regulation of neuroblast proliferation biological_process "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] EOG8RBT1M GO:2001020 1/201 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8RBT1M GO:0001964 1/201 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8RBT1M GO:0048190 1/201 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8RBT1M GO:0045466 1/201 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG8RBT1M GO:0001078 1/201 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8RBT1M GO:0048813 1/201 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8RBT1M GO:0048052 1/201 R1/R6 cell differentiation biological_process "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] EOG8RBT1M GO:0031987 1/201 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8RBT1M GO:0048854 1/201 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8RBT1N GO:0003677 1/44 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RBT1N GO:0004402 1/44 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8JHFW3 GO:0016491 83/244 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8JHFW3 GO:0046592 2/244 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG8JHFW3 GO:0046872 1/244 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JHFW3 GO:0050232 1/244 putrescine oxidase activity molecular_function "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] EOG8JHFW3 GO:0005615 1/244 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JHFW3 GO:0003676 1/244 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZHT GO:0007165 76/261 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG88GZHT GO:0005737 3/261 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88GZHT GO:0016059 2/261 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG88GZHT GO:0002046 2/261 opsin binding molecular_function "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] EOG88GZHT GO:0007601 2/261 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG88GZHT GO:0016028 2/261 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG88GZHT GO:0045494 2/261 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG88GZHT GO:0005515 2/261 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88GZHT GO:0016060 2/261 metarhodopsin inactivation biological_process "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] EOG88GZHT GO:0035641 1/261 locomotory exploration behavior biological_process "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232] EOG88GZHT GO:0016029 1/261 subrhabdomeral cisterna cellular_component "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] EOG88GZHT GO:0007605 1/261 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG88GZHT GO:0002168 1/261 instar larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG88GZHT GO:0045746 1/261 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG88GZHT GO:0005829 1/261 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG88GZHT GO:0016062 1/261 adaptation of rhodopsin mediated signaling biological_process "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] EOG88GZHT GO:0031647 1/261 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG88GZHT GO:0042335 1/261 cuticle development biological_process "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825] EOG88GZHT GO:0007369 1/261 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG88GZHT GO:0006897 1/261 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG88GZHT GO:0061099 1/261 negative regulation of protein tyrosine kinase activity biological_process "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] EOG8DNHK8 GO:0000155 1/71 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8DNHK8 GO:0022008 1/71 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8DNHK8 GO:0016020 1/71 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88GZHS GO:0003676 22/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZHS GO:0046872 13/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88GZHS GO:0008270 10/87 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88GZHS GO:0005811 1/87 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG88GZHS GO:0046331 1/87 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8WHC0K GO:0005814 1/87 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG8WHC0K GO:0035044 1/87 sperm aster formation biological_process "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] EOG8WHC0K GO:0030953 1/87 astral microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] EOG8WHC0K GO:0005813 1/87 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8WHC0K GO:0000242 1/87 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8WHC0K GO:0051297 1/87 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8WHC0K GO:0007052 1/87 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8ZW7SF GO:0008519 7/19 ammonium transmembrane transporter activity molecular_function "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732] EOG8ZW7SF GO:0016021 7/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SN443 GO:0003824 3/6 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN443 GO:0044237 3/6 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8SN443 GO:0050662 3/6 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG88GZHJ GO:0046872 26/118 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88GZHJ GO:0003676 26/118 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZGRSV GO:0008168 20/87 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8S4RXS GO:0005576 2/98 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S4RXS GO:0008201 1/98 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG800400 GO:0046331 2/92 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG800400 GO:0006816 2/92 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG800400 GO:0005262 2/92 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG800400 GO:0005764 2/92 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG800400 GO:0044130 2/92 negative regulation of growth of symbiont in host biological_process "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] EOG800400 GO:0006914 2/92 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG800400 GO:0006874 2/92 cellular calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] EOG800400 GO:0032008 2/92 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG800400 GO:0070588 2/92 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG800400 GO:0005765 2/92 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG800400 GO:0000046 2/92 autophagosome maturation biological_process "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139] EOG800400 GO:0031902 2/92 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8S4RXV GO:0005634 13/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S4RXV GO:0043565 12/73 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8S4RXV GO:0008270 12/73 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S4RXV GO:0006351 11/73 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8S4RXV GO:0003700 11/73 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8S4RXV GO:0003707 11/73 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8S4RXV GO:0004879 2/73 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8S4RXV GO:0003677 1/73 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X0Q86 GO:0003677 11/50 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X0Q86 GO:0006284 11/50 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8X0Q86 GO:0003905 8/50 alkylbase DNA N-glycosylase activity molecular_function "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] EOG8X0Q86 GO:0052821 3/50 DNA-7-methyladenine glycosylase activity molecular_function "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site." [GOC:jl, PMID:16468998] EOG8X0Q86 GO:0052822 3/50 DNA-3-methylguanine glycosylase activity molecular_function "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] EOG8X0Q86 GO:0043916 3/50 DNA-7-methylguanine glycosylase activity molecular_function "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998] EOG8X0Q86 GO:0008725 3/50 DNA-3-methyladenine glycosylase activity molecular_function "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] EOG8CNT6Z GO:0016021 22/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CNT6Z GO:0007163 1/92 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8CNT6Z GO:0005918 1/92 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8X0Q82 GO:0030170 1/6 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8X0Q82 GO:0004413 1/6 homoserine kinase activity molecular_function "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13988] EOG8X0Q82 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X0Q82 GO:0006566 1/6 threonine metabolic process biological_process "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8SJ7TP GO:0030163 1/18 protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] EOG8SJ7TP GO:0004252 1/18 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8SJ7TP GO:0004176 1/18 ATP-dependent peptidase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] EOG8SJ7TP GO:0005524 1/18 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SJ7TR GO:0030308 1/118 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8SJ7TR GO:0048190 1/118 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8SJ7TR GO:0005634 1/118 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SJ7TR GO:0000122 1/118 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0006351 1/118 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SJ7TR GO:0045892 1/118 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0005515 1/118 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SJ7TR GO:0070491 1/118 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8SJ7TR GO:0007474 1/118 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8SJ7TR GO:0046843 1/118 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8SJ7TR GO:0048592 1/118 eye morphogenesis biological_process "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] EOG8SJ7TR GO:0006355 1/118 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TR GO:0007362 1/118 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8SJ7TR GO:0043565 1/118 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG851H6T GO:0004252 3/63 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG851H6T GO:0005509 3/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG851H6T GO:0016021 3/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8W3W2P GO:0015031 3/17 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8W3W2P GO:0005789 3/17 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8W3W2P GO:0016021 3/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85MQNG GO:0016301 8/464 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG85MQNG GO:0005576 3/464 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85MQNG GO:0004672 1/464 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG85MQNG GO:0045297 1/464 post-mating behavior biological_process "The specific behavior of an organism following mating." [GOC:bf, GOC:pr] EOG85MQNG GO:0006468 1/464 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG85MQNG GO:0004674 1/464 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8W3W2W GO:0045879 1/39 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8W3W2W GO:0005634 1/39 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8W3W2W GO:0001736 1/39 establishment of planar polarity biological_process "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] EOG8W3W2W GO:0035317 1/39 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG8W3W2W GO:0008270 1/39 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8W3W2W GO:0004181 1/39 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG85MQNQ GO:0005737 27/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85MQNQ GO:0016021 1/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85MQNQ GO:0008360 1/98 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8KSRZM GO:0001104 24/102 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8KSRZM GO:0016592 24/102 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8KSRZM GO:0005515 1/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KSRZM GO:0036011 1/102 imaginal disc-derived leg segmentation biological_process "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] EOG8KSRZM GO:0022416 1/102 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8KSRZM GO:0006367 1/102 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8KSRZM GO:0006357 1/102 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8KSRZM GO:0048749 1/102 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8KSRZM GO:0030177 1/102 positive regulation of Wnt signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] EOG8KSRZM GO:0045498 1/102 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG837TWK GO:0004725 39/155 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG837TWK GO:0003993 32/155 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG837TWK GO:0005737 31/155 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG837TWK GO:0004726 30/155 non-membrane spanning protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] EOG837TWK GO:0006470 3/155 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG837TWK GO:0035335 3/155 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG837TWK GO:0003963 1/155 RNA-3'-phosphate cyclase activity molecular_function "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] EOG8KSRZK GO:0005524 11/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KSRZK GO:0004674 9/91 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8KSRZK GO:0004687 1/91 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8KSRZK GO:0004672 1/91 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8THZ7M GO:0003676 17/61 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8THZ7M GO:0046872 17/61 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8R2696 GO:0006334 23/75 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8R2696 GO:0005634 23/75 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8935ZN GO:0008270 12/56 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8935ZN GO:0016491 11/56 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8935ZN GO:0008743 1/56 L-threonine 3-dehydrogenase activity molecular_function "Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH." [EC:1.1.1.103, RHEA:25657] EOG85MQN0 GO:0003964 1/38 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG85MQN0 GO:0046872 1/38 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8THZ7X GO:0006564 29/91 L-serine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] EOG8THZ7X GO:0004617 29/91 phosphoglycerate dehydrogenase activity molecular_function "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] EOG8THZ7X GO:0051287 28/91 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8THZ7X GO:0048037 1/91 cofactor binding molecular_function "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] EOG883GKT GO:0003676 5/26 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GKT GO:0003677 1/26 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8THZ7W GO:0000166 17/100 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8THZ7W GO:0003676 17/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85B3XK GO:0016787 2/13 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG85B3XK GO:0016813 1/13 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] EOG85B3XK GO:0016705 1/13 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG85B3XK GO:0046872 1/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85B3XK GO:0008080 1/13 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8X0Q8D GO:0008270 12/19 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X0Q8D GO:0005634 12/19 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X0Q8D GO:0046872 2/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X0Q8D GO:0003676 1/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG57 GO:0043234 1/90 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG80GG57 GO:0007140 1/90 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG80GG57 GO:0005737 1/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80GG57 GO:0000347 1/90 THO complex cellular_component "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] EOG80GG57 GO:0008283 1/90 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG80GG57 GO:0009408 1/90 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8JWXTJ GO:0005524 25/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JWXTJ GO:0003678 25/90 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8JWXTJ GO:0042555 25/90 MCM complex cellular_component "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] EOG8JWXTJ GO:0006270 25/90 DNA replication initiation biological_process "The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] EOG8JWXTJ GO:0003677 25/90 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JWXTJ GO:0005634 25/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JWXTJ GO:0005875 1/90 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8JWXTJ GO:0032508 1/90 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8JWXTJ GO:0007095 1/90 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8ZGRSD GO:0005097 11/49 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8ZGRSD GO:0006338 1/49 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8ZGRSD GO:0000228 1/49 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8S4RX4 GO:0016021 39/114 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RX4 GO:0005886 37/114 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8S4RX4 GO:0050909 34/114 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8S4RX4 GO:0008527 6/114 taste receptor activity molecular_function "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] EOG8S4RX4 GO:0032098 1/114 regulation of appetite biological_process "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] EOG8S4RX4 GO:0033041 1/114 sweet taste receptor activity molecular_function "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] EOG8S4RX4 GO:0060259 1/114 regulation of feeding behavior biological_process "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] EOG8S4RX4 GO:0071332 1/114 cellular response to fructose stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah] EOG8S4RX4 GO:0001582 1/114 detection of chemical stimulus involved in sensory perception of sweet taste biological_process "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] EOG8S4RX4 GO:0050912 1/114 detection of chemical stimulus involved in sensory perception of taste biological_process "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG8S4RX4 GO:0008343 1/114 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG8S4RX4 GO:0050916 1/114 sensory perception of sweet taste biological_process "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG851H65 GO:0003676 3/28 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K0T2W GO:0004402 3/114 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8K0T2W GO:0005875 1/114 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8K0T2W GO:0055059 1/114 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8K0T2W GO:0061343 1/114 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG8K0T2W GO:0007015 1/114 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8K0T2W GO:0004871 1/114 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8K0T2W GO:0005886 1/114 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8K0T2W GO:0045176 1/114 apical protein localization biological_process "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] EOG80S2X2 GO:0006412 25/152 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG80S2X2 GO:0003735 25/152 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG80S2X2 GO:0015935 24/152 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG80S2X2 GO:0005763 1/152 mitochondrial small ribosomal subunit cellular_component "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] EOG80S2X2 GO:0004402 1/152 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG80S2X5 GO:0006546 1/3 glycine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] EOG80S2X5 GO:0004047 1/3 aminomethyltransferase activity molecular_function "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] EOG80S2X5 GO:0005737 1/3 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80S2X5 GO:0006464 1/3 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG80S2X5 GO:0070403 1/3 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG80S2X5 GO:0008474 1/3 palmitoyl-(protein) hydrolase activity molecular_function "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] EOG8K0T2Q GO:0005524 1/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K0T2Q GO:0032440 1/9 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8K0T2Q GO:0006950 1/9 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8S1WNZ GO:0005089 21/95 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8S1WNZ GO:0007155 1/95 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8S1WNZ GO:0008360 1/95 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8S1WNZ GO:0007480 1/95 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG89KJ63 GO:0005615 4/10 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG89KJ63 GO:0008233 1/10 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG834ZMF GO:0005730 29/92 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG834ZMF GO:0006364 29/92 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG834ZMF GO:0016905 1/92 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG8K0T2B GO:0006435 1/11 threonyl-tRNA aminoacylation biological_process "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8K0T2B GO:0005737 1/11 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K0T2B GO:0004828 1/11 serine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] EOG8K0T2B GO:0004813 1/11 alanine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] EOG8K0T2B GO:0004829 1/11 threonine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] EOG8K0T2B GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8S1WND GO:0030554 26/95 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8S1WND GO:0006177 23/95 GMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] EOG8S1WND GO:0003938 23/95 IMP dehydrogenase activity molecular_function "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] EOG8S1WND GO:0046872 23/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S1WND GO:0005737 21/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8S1WND GO:0016491 2/95 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8S1WND GO:0007411 1/95 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8S1WND GO:0003824 1/95 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S1WND GO:0006909 1/95 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8S1WND GO:0055114 1/95 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8S1WND GO:0048477 1/95 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8K0T2M GO:0003997 51/180 acyl-CoA oxidase activity molecular_function "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] EOG8K0T2M GO:0005777 51/180 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8K0T2M GO:0003995 51/180 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8K0T2M GO:0006635 48/180 fatty acid beta-oxidation biological_process "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] EOG8K0T2M GO:0050660 48/180 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8K0T2M GO:0006631 3/180 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG8K0T2M GO:0004970 1/180 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8K0T2M GO:0005234 1/180 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8K0T2M GO:0016020 1/180 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8K0T2M GO:0006909 1/180 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8S1WNN GO:0016021 25/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S1WNN GO:0016485 25/76 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8S1WNN GO:0055037 1/76 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG8S1WNN GO:0007219 1/76 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8S1WNN GO:0045314 1/76 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG8S1WNN GO:0007010 1/76 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8S1WNN GO:0046331 1/76 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8S1WNN GO:0070765 1/76 gamma-secretase complex cellular_component "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368] EOG8S1WNN GO:0006509 1/76 membrane protein ectodomain proteolysis biological_process "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] EOG8S1WNN GO:0008594 1/76 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8S1WNN GO:0005770 1/76 late endosome cellular_component "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] EOG8S1WNN GO:0007220 1/76 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8S1WNN GO:0045463 1/76 R8 cell development biological_process "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] EOG8VDSG8 GO:0003676 13/68 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSG8 GO:0008270 13/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RV568 GO:0006457 29/93 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8RV568 GO:0003755 5/93 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8RV568 GO:0018208 2/93 peptidyl-proline modification biological_process "The modification of peptidyl-proline." [GOC:go_curators] EOG8RV568 GO:0000413 2/93 protein peptidyl-prolyl isomerization biological_process "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] EOG8RV568 GO:0016020 2/93 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RV568 GO:0005528 2/93 FK506 binding molecular_function "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] EOG8RV568 GO:0034587 1/93 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG8RV568 GO:0048477 1/93 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8RV568 GO:0031047 1/93 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8RV568 GO:0007126 1/93 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8RV568 GO:0043186 1/93 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8RV568 GO:0070725 1/93 Yb body cellular_component "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453] EOG8RV568 GO:0005737 1/93 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JDKNX GO:0055114 1/3 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8JDKNX GO:0004497 1/3 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8RV567 GO:0003723 1/5 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RV567 GO:0004349 1/5 glutamate 5-kinase activity molecular_function "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14880] EOG8RV567 GO:0005737 1/5 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RV567 GO:0006561 1/5 proline biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] EOG8RV561 GO:0006071 14/62 glycerol metabolic process biological_process "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] EOG8RV561 GO:0004371 14/62 glycerone kinase activity molecular_function "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15776] EOG8WM7B8 GO:0016021 1/12 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MKQXF GO:0003676 7/27 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WM7B5 GO:0005576 2/27 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PZMPV GO:0009055 24/85 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8PZMPV GO:0046872 24/85 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PZMPV GO:0051537 22/85 2 iron, 2 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8PZMPV GO:0051536 2/85 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8JHFXB GO:0000166 32/160 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8JHFXB GO:0003676 31/160 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JHFXB GO:0005634 1/160 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JHFXB GO:0015450 1/160 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] EOG8JHFXB GO:0071011 1/160 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8JHFXB GO:0007293 1/160 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8JHFXB GO:0048477 1/160 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8JHFXB GO:0019013 1/160 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8JHFXB GO:0006405 1/160 RNA export from nucleus biological_process "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] EOG8JHFXB GO:0008298 1/160 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8JHFXB GO:0030720 1/160 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG8JHFXB GO:0005737 1/160 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JHFXB GO:0019094 1/160 pole plasm mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8JHFXB GO:0007297 1/160 ovarian follicle cell migration biological_process "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8JHFXB GO:0000398 1/160 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8JHFXB GO:0017148 1/160 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8JHFXB GO:0030529 1/160 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8JHFXB GO:0033119 1/160 negative regulation of RNA splicing biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] EOG8JHFXB GO:0016020 1/160 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8JHFXB GO:0045451 1/160 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8JHFXB GO:0006605 1/160 protein targeting biological_process "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] EOG8JHFXB GO:0006406 1/160 mRNA export from nucleus biological_process "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] EOG8JHFXB GO:0000184 1/160 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8JHFXB GO:0009953 1/160 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8JHFXB GO:0000785 1/160 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8JHFXB GO:0016325 1/160 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8JHFXB GO:0003730 1/160 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8JHFXB GO:0071013 1/160 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8JHFXB GO:0005703 1/160 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG8JHFXB GO:0003729 1/160 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8JHFXB GO:0008069 1/160 dorsal/ventral axis specification, ovarian follicular epithelium biological_process "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8JHFXB GO:0000381 1/160 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8JHFXB GO:0035062 1/160 omega speckle cellular_component "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] EOG8JHFXB GO:0007314 1/160 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8JDKN9 GO:0016226 25/87 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG8JDKN9 GO:0097361 25/87 CIA complex cellular_component "The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362] EOG8JDKN9 GO:0016746 1/87 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8JDKN9 GO:0022008 1/87 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8JDKN9 GO:0005515 1/87 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JDKN8 GO:0005215 1/6 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8JDKN8 GO:0055085 1/6 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8JDKN8 GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VQD70 GO:0005975 5/6 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8VQD70 GO:0016985 5/6 mannan endo-1,4-beta-mannosidase activity molecular_function "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] EOG8RV56V GO:0034314 37/99 Arp2/3 complex-mediated actin nucleation biological_process "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] EOG8RV56V GO:0005885 37/99 Arp2/3 protein complex cellular_component "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] EOG8RV56V GO:0003779 2/99 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8VQD77 GO:0005871 1/2 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8VQD77 GO:0007018 1/2 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8VQD77 GO:0003777 1/2 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8VQD77 GO:0005524 1/2 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MKQX1 GO:0005524 53/167 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MKQX1 GO:0004674 46/167 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8MKQX1 GO:0008353 6/167 RNA polymerase II carboxy-terminal domain kinase activity molecular_function "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] EOG8MKQX1 GO:0051301 4/167 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8MKQX1 GO:0004672 3/167 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8MKQX1 GO:0009987 2/167 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8MKQX1 GO:0007067 2/167 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8MKQX1 GO:0000082 2/167 G1/S transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] EOG8MKQX1 GO:0000086 2/167 G2/M transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] EOG8MKQX1 GO:0004693 2/167 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8MKQX1 GO:0006468 2/167 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8MKQX1 GO:0005875 2/167 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8MKQX1 GO:0005515 2/167 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8MKQX1 GO:0004713 1/167 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8MKQX1 GO:0022008 1/167 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MKQX1 GO:0048142 1/167 germarium-derived cystoblast division biological_process "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] EOG8MKQX1 GO:0032880 1/167 regulation of protein localization biological_process "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] EOG8MKQX1 GO:0044818 1/167 mitotic G2/M transition checkpoint biological_process "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8MKQX1 GO:0006974 1/167 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8MKQX1 GO:0008315 1/167 meiotic G2/MI transition biological_process "The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480] EOG8MKQX1 GO:0007141 1/167 male meiosis I biological_process "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] EOG8MKQX1 GO:0007283 1/167 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8MKQX1 GO:0007095 1/167 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8MKQX1 GO:0007259 1/167 JAK-STAT cascade biological_process "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] EOG8MKQX1 GO:0007140 1/167 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8MKQX1 GO:0000278 1/167 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8MKQX1 GO:0055059 1/167 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8MKQX1 GO:0007284 1/167 spermatogonial cell division biological_process "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] EOG8MKQX1 GO:0005634 1/167 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RJJJF GO:0000166 5/19 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8RJJJF GO:0003676 5/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86HJQX GO:0006396 25/97 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG86HJQX GO:0008173 25/97 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG86HJQX GO:0000166 23/97 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86HJQX GO:0003676 16/97 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86HJQX GO:0003723 2/97 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG86HJQX GO:0030697 1/97 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337] EOG86HJQX GO:0003729 1/97 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG84BDG4 GO:0008270 8/53 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RJJJK GO:0006351 2/10 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8RJJJK GO:0005634 2/10 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RJJJK GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RJJJK GO:0003677 2/10 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RJJJK GO:0003700 2/10 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8K0T27 GO:0005828 1/99 kinetochore microtubule cellular_component "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] EOG8K0T27 GO:0034501 1/99 protein localization to kinetochore biological_process "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] EOG8K0T27 GO:0005819 1/99 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8K0T27 GO:0007094 1/99 mitotic spindle assembly checkpoint biological_process "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] EOG8K0T27 GO:0000776 1/99 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG8K0T27 GO:0000940 1/99 condensed chromosome outer kinetochore cellular_component "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] EOG8K0T27 GO:0000070 1/99 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8K0T27 GO:0005737 1/99 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VDSGG GO:0052689 1/6 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8S1WN0 GO:0004842 30/94 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8S1WN0 GO:0042787 1/94 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8S1WN0 GO:0000151 1/94 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG8S1WN0 GO:0010629 1/94 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8S1WN0 GO:0007293 1/94 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8S1WN0 GO:0048619 1/94 embryonic hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG8S1WN0 GO:0005515 1/94 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8S1WN0 GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WN0 GO:0008101 1/94 decapentaplegic signaling pathway biological_process "A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827] EOG8S1WN0 GO:0001700 1/94 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8S1WN0 GO:0040008 1/94 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG8S1WN0 GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8S1WN0 GO:0030514 1/94 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8S1WN4 GO:0003676 46/166 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S1WN4 GO:0004527 42/166 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8S1WN4 GO:0046872 6/166 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S1WN4 GO:0008859 1/166 exoribonuclease II activity molecular_function "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] EOG8S1WN4 GO:0000166 1/166 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8S1WN4 GO:0003746 1/166 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8S1WN4 GO:0035556 1/166 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG89KJ6W GO:0030036 9/39 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG89KJ6W GO:0005856 9/39 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8GMX9W GO:0016757 1/104 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8GMX9W GO:0035220 1/104 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8GMX9W GO:0016740 1/104 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8GMX9W GO:0045475 1/104 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8GMX9W GO:0006486 1/104 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8GMX9W GO:0008375 1/104 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG8GMX9V GO:0005509 10/86 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GMX9V GO:0003824 2/86 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8JDKPV GO:0005549 46/151 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8JDKPV GO:0007606 2/151 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8JDKPV GO:0007608 2/151 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8JDKPV GO:0006810 2/151 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8JDKPV GO:0019236 2/151 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8JDKPV GO:0042048 2/151 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8JDKPV GO:0005576 2/151 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JDKPV GO:0045471 1/151 response to ethanol biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] EOG8JDKPV GO:0005550 1/151 pheromone binding molecular_function "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] EOG8JDKPV GO:0035274 1/151 diphenyl phthalate binding molecular_function "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] EOG8JDKPV GO:0035275 1/151 dibutyl phthalate binding molecular_function "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] EOG8JDKPV GO:0007619 1/151 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG85XBFM GO:0003676 1/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG5K GO:0016787 32/103 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80GG5K GO:0003948 11/103 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity molecular_function "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547] EOG80GG5K GO:0006517 8/103 protein deglycosylation biological_process "The removal of sugar residues from a glycosylated protein." [GOC:mah] EOG80GG5K GO:0008233 8/103 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG80GG5K GO:0005764 8/103 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG869T7S GO:0004252 36/209 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG869T7S GO:0016787 1/209 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG869T7S GO:0006508 1/209 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG841SR5 GO:0009058 1/88 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG80GG5C GO:0046872 107/320 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80GG5C GO:0003676 107/320 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG5C GO:0016787 102/320 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80GG5C GO:0006309 4/320 apoptotic DNA fragmentation biological_process "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] EOG80GG5C GO:0005739 4/320 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80GG5C GO:0004518 4/320 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG80GG5C GO:0004519 1/320 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG841SR9 GO:0003677 2/14 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG841SR9 GO:0022008 1/14 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8TTJZ4 GO:0004373 25/98 glycogen (starch) synthase activity molecular_function "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] EOG8TTJZ4 GO:0005978 25/98 glycogen biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] EOG8TTJZ4 GO:0080019 1/98 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8TTJZ4 GO:0031410 1/98 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8TTJZ4 GO:0005776 1/98 autophagosome cellular_component "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] EOG8PVRDQ GO:0004089 5/118 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8PVRDQ GO:0008270 4/118 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRDQ GO:0006730 4/118 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8TTJZ0 GO:0006511 30/95 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8TTJZ0 GO:0008270 26/95 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TTJZ0 GO:0008234 23/95 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8TTJZ0 GO:0008242 22/95 omega peptidase activity molecular_function "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] EOG8TTJZ0 GO:0048812 1/95 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8TTJZ0 GO:0016787 1/95 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80GG5P GO:0030170 1/7 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG80GG5P GO:0008890 1/7 glycine C-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739] EOG80GG5P GO:0009058 1/7 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG893614 GO:0003676 17/107 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG893614 GO:0004523 17/107 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG893614 GO:0003723 1/107 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG893614 GO:0003964 1/107 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8PP0XP GO:0006491 26/165 N-glycan processing biological_process "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] EOG8PP0XP GO:0005509 19/165 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8PP0XP GO:0032450 2/165 maltose alpha-glucosidase activity molecular_function "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] EOG8PP0XP GO:0016301 1/165 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8PP0XP GO:0046331 1/165 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG88WFG4 GO:0007165 4/72 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG88WFG4 GO:0032440 1/72 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8K3PBV GO:0003723 24/85 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8K3PBV GO:0005737 24/85 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K3PBV GO:0003824 24/85 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8K3PBV GO:0006355 24/85 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8M3CQ7 GO:0000166 20/79 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8M3CQ7 GO:0003723 13/79 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8M3CQ7 GO:0006396 13/79 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8M3CQ7 GO:0005634 13/79 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M3CQ7 GO:0030529 13/79 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8M3CQ7 GO:0019013 2/79 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8K3PBS GO:0016740 5/476 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8K3PBS GO:0016021 5/476 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8K3PBS GO:0003676 1/476 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K3PBS GO:0008270 1/476 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NGK26 GO:0004984 69/207 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8NGK26 GO:0005549 69/207 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8NGK26 GO:0004930 64/207 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NGK26 GO:0016021 64/207 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NGK26 GO:0005886 49/207 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NGK26 GO:0016020 5/207 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NGK26 GO:0050911 3/207 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG8NGK26 GO:0007608 2/207 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8NGK26 GO:0007186 2/207 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8NGK26 GO:0051291 1/207 protein heterooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8NGK26 GO:0032590 1/207 dendrite membrane cellular_component "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] EOG8NGK26 GO:0004888 1/207 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8NGK20 GO:0005615 18/55 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8NGK20 GO:0009611 1/55 response to wounding biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] EOG8NGK20 GO:0030162 1/55 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8NGK20 GO:0035009 1/55 negative regulation of melanization defense response biological_process "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] EOG8NGK20 GO:0010951 1/55 negative regulation of endopeptidase activity biological_process "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] EOG8NGK20 GO:0004867 1/55 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8NGK20 GO:0045861 1/55 negative regulation of proteolysis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] EOG8NGK20 GO:0016740 1/55 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8NGK23 GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NGK23 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NGK23 GO:0042626 1/6 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8N8TKG GO:0005549 42/224 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8GF5X2 GO:0019028 2/54 viral capsid cellular_component "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] EOG8GF5X2 GO:0005198 2/54 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8K3PBC GO:0017111 1/7 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8K3PBC GO:0006355 1/7 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8K3PBC GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8K3PBC GO:0043565 1/7 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8JHFXW GO:0016818 1/5 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] EOG8JHFXW GO:0006355 1/5 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8JHFXW GO:0005634 1/5 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JHFXW GO:0003677 1/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JHFXW GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JHFXW GO:0008270 1/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1XZ GO:0003676 2/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M3CQX GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CQX GO:0016887 1/6 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8N8TK4 GO:0008270 1/19 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N8TK4 GO:0003677 1/19 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NGK2N GO:0004252 12/110 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8NGK2N GO:0020037 1/110 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8NGK2N GO:0016705 1/110 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8NGK2N GO:0005506 1/110 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8GF5XB GO:0003676 4/39 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GF5XB GO:0046872 4/39 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M3CQM GO:0004158 1/3 dihydroorotate oxidase activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444] EOG8M3CQM GO:0016020 1/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M3CQM GO:0006207 1/3 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG8M3CQM GO:0006222 1/3 UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] EOG8M3CQJ GO:0007498 1/145 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8M3CQH GO:0007018 23/95 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8M3CQH GO:0005524 23/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CQH GO:0003777 23/95 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8M3CQH GO:0005871 23/95 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8M3CQH GO:0005874 23/95 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8M3CQH GO:0031534 1/95 minus-end directed microtubule sliding biological_process "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] EOG8M3CQH GO:0032837 1/95 distributive segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] EOG8M3CQH GO:0090307 1/95 mitotic spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw] EOG8M3CQH GO:0000212 1/95 meiotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] EOG8M3CQH GO:0007059 1/95 chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] EOG8M3CQH GO:1901673 1/95 regulation of mitotic spindle assembly biological_process "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] EOG8M3CQH GO:0001578 1/95 microtubule bundle formation biological_process "A process that results in a parallel arrangement of microtubules." [GOC:dph] EOG8M3CQH GO:0005819 1/95 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8M3CQH GO:0042803 1/95 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8M3CQH GO:0007056 1/95 spindle assembly involved in female meiosis biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] EOG8M3CQH GO:0008569 1/95 ATP-dependent microtubule motor activity, minus-end-directed molecular_function "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw] EOG8M3CQH GO:0007052 1/95 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8M3CQH GO:0007100 1/95 mitotic centrosome separation biological_process "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] EOG8M3CQH GO:0008152 1/95 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8M3CQH GO:0032888 1/95 regulation of mitotic spindle elongation biological_process "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] EOG8M3CQH GO:0005829 1/95 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8M3CQH GO:0000022 1/95 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8M3CQH GO:0090306 1/95 spindle assembly involved in meiosis biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] EOG8M3CQH GO:0007051 1/95 spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] EOG8M3CQH GO:0051297 1/95 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8M3CQH GO:0051298 1/95 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8GF5XT GO:0042302 5/11 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG883GKM GO:0005525 2/3 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG883GKM GO:0003924 2/3 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG883GKM GO:0003746 1/3 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8SBHDW GO:0006241 1/11 CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG8SBHDW GO:0004550 1/11 nucleoside diphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] EOG8SBHDW GO:0006228 1/11 UTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] EOG8SBHDW GO:0006183 1/11 GTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8SBHDW GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG883GKG GO:0000179 25/85 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] EOG883GKG GO:0052909 1/85 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity molecular_function "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA." [EC:2.1.1.183] EOG883GKG GO:0022008 1/85 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG883GKG GO:0003723 1/85 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG883GKG GO:0005730 1/85 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8SBHDR GO:0009058 17/31 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8SBHDR GO:0005794 17/31 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8SBHDR GO:0001733 17/31 galactosylceramide sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] EOG8SBHDR GO:0016021 17/31 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG883GKB GO:0005215 1/10 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG883GKB GO:0016887 1/10 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG883GKB GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG883GKB GO:0016021 1/10 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG883GKB GO:0016491 1/10 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80GG53 GO:0051539 26/94 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG80GG53 GO:0009451 26/94 RNA modification biological_process "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] EOG80GG53 GO:0016740 26/94 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG80GG53 GO:0016021 2/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80GG53 GO:0008033 2/94 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG80GG53 GO:0046872 2/94 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80GG53 GO:0032440 1/94 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8SBHDF GO:0016021 26/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SBHDF GO:0004930 26/99 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8SBHDF GO:0050254 2/99 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8SBHDF GO:0097004 1/99 adipokinetic hormone binding molecular_function "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG8SBHDF GO:0097003 1/99 adipokinetic hormone receptor activity molecular_function "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG8SBHDF GO:0005887 1/99 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SBHDF GO:0007218 1/99 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8SBHDF GO:0006117 1/99 acetaldehyde metabolic process biological_process "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [CHEBI:15343, GOC:go_curators] EOG8SBHDF GO:0048149 1/99 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8SBHDF GO:0071361 1/99 cellular response to ethanol biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah] EOG8SBHDF GO:0035237 1/99 corazonin receptor activity molecular_function "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] EOG8SBHDF GO:0008188 1/99 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8SBHDF GO:0007186 1/99 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG883GKV GO:0003677 1/93 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SBHDC GO:0008270 11/64 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SBHDC GO:0005634 10/64 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N06Z7 GO:0004930 1/4 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8N06Z7 GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N3339 GO:0007264 13/95 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8N3339 GO:0005622 13/95 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8N3339 GO:0005089 10/95 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8N3339 GO:0005085 3/95 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8N3339 GO:0051056 2/95 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8N3339 GO:0016740 1/95 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8N3335 GO:0016021 27/111 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N3335 GO:0005337 27/111 nucleoside transmembrane transporter activity molecular_function "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] EOG8KPWST GO:0016021 27/105 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KPWST GO:0046872 1/105 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KPWST GO:0004784 1/105 superoxide dismutase activity molecular_function "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] EOG8KPWSS GO:0008255 1/60 ecdysis-triggering hormone activity molecular_function "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] EOG8KPWSS GO:0018990 1/60 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8KPWSS GO:0005102 1/60 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG8KPWSS GO:0005184 1/60 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8KPWSS GO:0001664 1/60 G-protein coupled receptor binding molecular_function "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] EOG8KPWSS GO:0007218 1/60 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8KPWSS GO:0005615 1/60 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8KPWSN GO:0006505 1/12 GPI anchor metabolic process biological_process "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732] EOG8KPWSN GO:0006221 1/12 pyrimidine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8KPWSN GO:0006886 1/12 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8KPWSN GO:0016788 1/12 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8KPWSN GO:0003883 1/12 CTP synthase activity molecular_function "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] EOG880M9H GO:0005524 26/122 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG880M9H GO:0005003 22/122 ephrin receptor activity molecular_function "Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] EOG880M9H GO:0005887 18/122 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG880M9H GO:0016021 6/122 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG880M9H GO:0004713 5/122 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG880M9H GO:0007422 1/122 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG880M9H GO:0004714 1/122 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG880M9H GO:0048013 1/122 ephrin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] EOG880M9H GO:0043565 1/122 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG880M9H GO:0005886 1/122 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG880M9H GO:0003700 1/122 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG880M9H GO:0006468 1/122 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG880M9H GO:0016319 1/122 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG880M9H GO:0007165 1/122 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG880M9H GO:0005328 1/122 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG880M9H GO:0004568 1/122 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG880M9H GO:0035011 1/122 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG880M9H GO:0004672 1/122 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG880M9H GO:0018108 1/122 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8RBT0W GO:0016539 2/87 intein-mediated protein splicing biological_process "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] EOG8RBT0W GO:0016301 2/87 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8RBT0W GO:0071011 1/87 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8RBT0W GO:0004402 1/87 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8RBT0W GO:0000398 1/87 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8RBT0W GO:0071013 1/87 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG880M9D GO:0005524 21/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG880M9D GO:0016773 18/101 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG880M9D GO:0016301 18/101 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG880M9D GO:0004674 4/101 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG880M9D GO:0007275 1/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG880M9D GO:0035173 1/101 histone kinase activity molecular_function "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] EOG880M9D GO:0016233 1/101 telomere capping biological_process "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] EOG880M9D GO:0000781 1/101 chromosome, telomeric region cellular_component "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] EOG880M9D GO:0005576 1/101 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG880M9D GO:0006348 1/101 chromatin silencing at telomere biological_process "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] EOG880M9D GO:0007095 1/101 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG880M9D GO:0000723 1/101 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG880M9D GO:1990164 1/101 histone H2A phosphorylation biological_process "The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121] EOG880M9D GO:0030717 1/101 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG880M9D GO:0004672 1/101 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG880M9D GO:0000706 1/101 meiotic DNA double-strand break processing biological_process "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] EOG880M9D GO:0016310 1/101 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG880M9D GO:0051276 1/101 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG880M9D GO:0045494 1/101 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG880M9D GO:0007093 1/101 mitotic cell cycle checkpoint biological_process "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] EOG880M9D GO:0005634 1/101 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG880M9D GO:0016740 1/101 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8RZ1D2 GO:0003677 5/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RZ1D2 GO:0005634 5/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81RS84 GO:0008658 4/12 penicillin binding molecular_function "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] EOG81RS84 GO:0046677 1/12 response to antibiotic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] EOG81RS85 GO:0004767 35/120 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG81RS85 GO:0006685 32/120 sphingomyelin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] EOG81RS85 GO:0016787 1/120 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG808QQ0 GO:0016020 51/173 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG808QQ0 GO:0008324 51/173 cation transmembrane transporter activity molecular_function "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] EOG808QQ0 GO:0003677 5/173 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG808QQ0 GO:0006281 5/173 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG86Q985 GO:0003677 10/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86Q985 GO:0003676 3/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86Q985 GO:0005622 1/105 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG808QQB GO:0016891 2/7 endoribonuclease activity, producing 5'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] EOG808QQB GO:0042779 2/7 tRNA 3'-trailer cleavage biological_process "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators] EOG8RZ1DV GO:0003677 10/252 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RZ1DV GO:0015074 5/252 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8RZ1DV GO:0006310 5/252 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8RZ1DV GO:0003676 1/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RZ1DV GO:0003723 1/252 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RZ1DV GO:0003964 1/252 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG808QQG GO:0030170 2/6 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG808QQG GO:0009058 2/6 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG808QQG GO:0080130 1/6 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] EOG808QQG GO:0003824 1/6 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG808QQG GO:0004069 1/6 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] EOG808QQH GO:0006749 13/21 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG808QQH GO:0003840 13/21 gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] EOG808QQH GO:0005215 3/21 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG808QQH GO:0016020 2/21 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG808QQH GO:0004725 2/21 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG808QQH GO:0016021 1/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG808QQH GO:0003700 1/21 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG808QQH GO:0005524 1/21 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG808QQH GO:0016887 1/21 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8RZ1DX GO:0006633 132/423 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RZ1DX GO:0016021 132/423 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DX GO:0016717 92/423 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG8RZ1DX GO:0004768 40/423 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG8RZ1DX GO:0005783 36/423 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8RZ1DX GO:0005506 35/423 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8RZ1DX GO:0060179 1/423 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8RZ1DX GO:0042811 1/423 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0004984 1/423 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8RZ1DX GO:0010506 1/423 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8RZ1DX GO:0007619 1/423 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8RZ1DX GO:0005811 1/423 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8RZ1DX GO:0048047 1/423 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8RZ1DX GO:0042810 1/423 pheromone metabolic process biological_process "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0042593 1/423 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG8RZ1DX GO:0070328 1/423 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8RZ1DX GO:0000281 1/423 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8RZ1DX GO:0006909 1/423 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8RZ1DX GO:0031410 1/423 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8RZ1DX GO:0019216 1/423 regulation of lipid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] EOG8RZ1DX GO:0005549 1/423 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8RZ1DX GO:0009744 1/423 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8RZ1DX GO:0006723 1/423 cuticle hydrocarbon biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] EOG81RS8W GO:0043565 19/81 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG81RS8W GO:0003700 19/81 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81RS8W GO:0005634 14/81 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81RS8W GO:0007275 8/81 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81RS8W GO:0003677 2/81 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81RS8W GO:0048813 1/81 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG81RS8W GO:0007517 1/81 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8642RS GO:0005524 25/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8642RS GO:0005856 21/106 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8642RS GO:0004715 17/106 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8642RS GO:0004713 8/106 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8642RS GO:0016020 4/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8642RS GO:0035556 3/106 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8642RS GO:0007259 1/106 JAK-STAT cascade biological_process "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] EOG8642RS GO:0016318 1/106 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8642RS GO:0007399 1/106 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8642RS GO:0048477 1/106 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8642RS GO:0045610 1/106 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8642RS GO:0006355 1/106 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8642RS GO:0046425 1/106 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG8642RS GO:0012505 1/106 endomembrane system cellular_component "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] EOG8642RS GO:0045475 1/106 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8642RS GO:0007616 1/106 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8642RS GO:0016301 1/106 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8642RS GO:0042386 1/106 hemocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] EOG8642RS GO:0007442 1/106 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG8642RS GO:0007350 1/106 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8642RS GO:0035171 1/106 lamellocyte differentiation biological_process "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] EOG8642RS GO:0006959 1/106 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8642RS GO:0042078 1/106 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG8642RS GO:0007365 1/106 periodic partitioning biological_process "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] EOG8642RS GO:0007260 1/106 tyrosine phosphorylation of STAT protein biological_process "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] EOG8642RS GO:0001745 1/106 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8642RS GO:0060031 1/106 mediolateral intercalation biological_process "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082] EOG8642RS GO:0007455 1/106 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8642RS GO:0035010 1/106 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8642RS GO:0004672 1/106 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8642RS GO:0007298 1/106 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8642RS GO:0045317 1/106 equator specification biological_process "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] EOG8642RS GO:0030713 1/106 ovarian follicle cell stalk formation biological_process "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8642RS GO:0016476 1/106 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8642RS GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8642RS GO:0008283 1/106 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8642RS GO:0007262 1/106 STAT protein import into nucleus biological_process "The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] EOG8642RS GO:0006351 1/106 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8642RS GO:0006955 1/106 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8642RS GO:0048749 1/106 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8642RS GO:0030097 1/106 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG8642RS GO:0007530 1/106 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG8642RS GO:0003383 1/106 apical constriction biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8642RS GO:0006968 1/106 cellular defense response biological_process "A defense response that is mediated by cells." [GOC:ebc] EOG8642RS GO:0006468 1/106 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8642RS GO:0030707 1/106 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8642RS GO:0048103 1/106 somatic stem cell division biological_process "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] EOG8642RS GO:0007480 1/106 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8642RS GO:0007424 1/106 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8642RS GO:0042067 1/106 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG8642RS GO:0007476 1/106 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8642RS GO:0051607 1/106 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8642RS GO:0035206 1/106 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8642RS GO:0001751 1/106 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8642RS GO:0035172 1/106 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8642RS GO:0035167 1/106 larval lymph gland hemopoiesis biological_process "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] EOG8642RS GO:0019827 1/106 stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] EOG8642RS GO:0007538 1/106 primary sex determination biological_process "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] EOG8PK4PD GO:0005524 81/297 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PK4PD GO:0004674 77/297 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PK4PD GO:0006468 5/297 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8PK4PD GO:0004683 4/297 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8PK4PD GO:0042594 2/297 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8PK4PD GO:0004672 2/297 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8PK4PD GO:0045169 1/297 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8PK4PD GO:0007015 1/297 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8PK4PD GO:0031594 1/297 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8PK4PD GO:0009798 1/297 axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] EOG8PK4PD GO:0055088 1/297 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8PK4PD GO:0061174 1/297 type I terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] EOG8PK4PD GO:0007317 1/297 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8PK4PD GO:0019730 1/297 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8PK4PD GO:0007318 1/297 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8PK4PD GO:0008360 1/297 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PK4PD GO:0000226 1/297 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8PK4PD GO:0030111 1/297 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8PK4PD GO:0007294 1/297 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8PK4PD GO:0007298 1/297 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PK4PD GO:0001737 1/297 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8PK4PD GO:0005938 1/297 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8PK4PD GO:0090176 1/297 microtubule cytoskeleton organization involved in establishment of planar polarity biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8PK4PD GO:0030709 1/297 border follicle cell delamination biological_process "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] EOG8PK4PD GO:0016323 1/297 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8PK4PD GO:0009994 1/297 oocyte differentiation biological_process "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] EOG8PK4PD GO:0051663 1/297 oocyte nucleus localization involved in oocyte dorsal/ventral axis specification biological_process "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8PK4PD GO:0045451 1/297 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8PK4PD GO:0045172 1/297 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8PK4PD GO:0050321 1/297 tau-protein kinase activity molecular_function "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] EOG8PK4PD GO:0007314 1/297 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8PK4PD GO:0009948 1/297 anterior/posterior axis specification biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PK4PD GO:0045185 1/297 maintenance of protein location biological_process "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] EOG8PK4PD GO:0030707 1/297 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PK4PD GO:0051124 1/297 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8PK4PD GO:0016325 1/297 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8ZW7R4 GO:0007015 10/56 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8ZW7R4 GO:0016477 10/56 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8ZW7R4 GO:0007155 10/56 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8ZPHBR GO:0035299 21/82 inositol pentakisphosphate 2-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316] EOG8ZPHBR GO:0005524 21/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPHBR GO:0032958 1/82 inositol phosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] EOG8N333T GO:0016851 1/7 magnesium chelatase activity molecular_function "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964] EOG8N333T GO:0015995 1/7 chlorophyll biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] EOG8N333T GO:0015979 1/7 photosynthesis biological_process "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] EOG8RNDQX GO:0008152 1/10 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8W6R8Q GO:0005543 21/112 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8W6R8Q GO:0008168 1/112 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8W6R8Q GO:0008091 1/112 spectrin cellular_component "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] EOG8W6R8Q GO:0016324 1/112 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8W6R8Q GO:0003676 1/112 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W6R8Q GO:0030707 1/112 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8W6R8Q GO:0010797 1/112 regulation of multivesicular body size involved in endosome transport biological_process "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] EOG8W6R8Q GO:0032509 1/112 endosome transport via multivesicular body sorting pathway biological_process "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] EOG8W6R8Q GO:0008092 1/112 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG8W6R8Q GO:0003779 1/112 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8W6R8Q GO:0042060 1/112 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8W6R8Q GO:0044267 1/112 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG8W6R8Q GO:0004725 1/112 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8W6R8Q GO:0005524 1/112 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8W6R8Q GO:0008017 1/112 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8W6R8Q GO:0016327 1/112 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG8W6R8Q GO:0000281 1/112 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8W6R8Q GO:0005515 1/112 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W6R8Q GO:0006897 1/112 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8W6R8Q GO:0007009 1/112 plasma membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8W6R8Q GO:0045186 1/112 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG8W6R8Q GO:0005912 1/112 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8W6R8Q GO:0016772 1/112 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8RNDQD GO:0016021 3/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RNDQD GO:0005216 3/27 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8RBT06 GO:0009890 2/79 negative regulation of biosynthetic process biological_process "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] EOG8RBT06 GO:0016787 1/79 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8RBT06 GO:0003676 1/79 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W6R8T GO:0005615 6/22 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8W6R8T GO:0004866 4/22 endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] EOG8N06ZC GO:0006412 1/6 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8N06ZC GO:0003735 1/6 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8N06ZC GO:0005840 1/6 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8N06ZC GO:0003723 1/6 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RBT08 GO:0046873 62/134 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8RBT08 GO:0016020 61/134 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RBT08 GO:0016324 3/134 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8RBT08 GO:0071578 2/134 zinc II ion transmembrane import biological_process "The directed movement of zinc II ions across a membrane into a cell or organelle." [GOC:BHF, GOC:mah] EOG8RBT08 GO:0005385 2/134 zinc ion transmembrane transporter activity molecular_function "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf] EOG8RBT08 GO:0032440 2/134 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8RBT08 GO:0005622 2/134 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8RBT08 GO:0016323 2/134 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8RBT08 GO:0008344 1/134 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8RBT08 GO:0008340 1/134 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8RBT08 GO:0055069 1/134 zinc ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] EOG8N333D GO:0000179 2/14 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] EOG8SJ7WW GO:0046580 1/95 negative regulation of Ras protein signal transduction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8G7FDM GO:0016888 3/14 endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] EOG8G7FDM GO:0003676 1/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X99X5 GO:0005622 2/114 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8X99X5 GO:0008270 2/114 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X99X5 GO:0035194 1/114 posttranscriptional gene silencing by RNA biological_process "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283] EOG8X99X5 GO:0005634 1/114 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X99X5 GO:0043186 1/114 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8RZ1DQ GO:0016491 10/35 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8THZ6X GO:0005871 19/79 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8THZ6X GO:0003777 19/79 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8THZ6X GO:0007018 19/79 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8THZ6X GO:0005524 18/79 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8THZ6X GO:0005874 15/79 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8THZ6X GO:0008574 1/79 ATP-dependent microtubule motor activity, plus-end-directed molecular_function "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP." [EC:3.6.4.4, GOC:vw] EOG8THZ6X GO:0030707 1/79 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8THZ6X GO:0045448 1/79 mitotic cell cycle, embryonic biological_process "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] EOG8THZ6X GO:0000792 1/79 heterochromatin cellular_component "A compact and highly condensed form of chromatin." [GOC:elh] EOG8THZ6X GO:0007126 1/79 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8THZ6X GO:0008157 1/79 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8THZ6X GO:0048477 1/79 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8THZ6X GO:0007076 1/79 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8THZ6X GO:0051726 1/79 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8THZ6X GO:0007059 1/79 chromosome segregation biological_process "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] EOG8THZ6X GO:0003682 1/79 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8THZ6X GO:0000070 1/79 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8G7FDQ GO:0016491 1/3 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8DNHJ8 GO:0051726 37/105 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8DNHJ8 GO:0006357 37/105 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8DNHJ8 GO:0005634 37/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DNHJ8 GO:0044212 2/105 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG8DNHJ8 GO:0035189 2/105 Rb-E2F complex cellular_component "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] EOG8DNHJ8 GO:0000122 2/105 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8DNHJ8 GO:0005515 2/105 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DNHJ8 GO:0008134 2/105 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8DNHJ8 GO:2000134 2/105 negative regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8DNHJ8 GO:0031523 2/105 Myb complex cellular_component "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] EOG8DNHJ8 GO:0001012 1/105 RNA polymerase II regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] EOG8DNHJ8 GO:0005654 1/105 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8DNHJ8 GO:0000785 1/105 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8DNHJ8 GO:0010629 1/105 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8DNHJ8 GO:0042023 1/105 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8DNHJ8 GO:0043066 1/105 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8DNHJ8 GO:0042127 1/105 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8DNHJ8 GO:0007307 1/105 eggshell chorion gene amplification biological_process "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] EOG8DNHJ8 GO:0034088 1/105 maintenance of mitotic sister chromatid cohesion biological_process "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] EOG8DNHJ8 GO:0051101 1/105 regulation of DNA binding biological_process "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] EOG8DNHJ8 GO:0008285 1/105 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8DNHJ8 GO:0071922 1/105 regulation of cohesin localization to chromatin biological_process "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] EOG8DNHJ8 GO:0008630 1/105 intrinsic apoptotic signaling pathway in response to DNA damage biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG8DNHJ8 GO:0051983 1/105 regulation of chromosome segregation biological_process "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] EOG8DNHJ8 GO:0007113 1/105 endomitotic cell cycle biological_process "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] EOG8DNHJ8 GO:0007095 1/105 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8DNHJ8 GO:0008156 1/105 negative regulation of DNA replication biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] EOG8DNHJ8 GO:0006351 1/105 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG80ZTCF GO:0003676 49/794 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80ZTCF GO:0003887 26/794 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG80ZTCF GO:0000166 26/794 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG80ZTCF GO:0046872 20/794 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80ZTCF GO:0008408 11/794 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG80ZTCF GO:0003677 11/794 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80ZTCF GO:0009103 1/794 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG80ZTCF GO:0006353 1/794 DNA-templated transcription, termination biological_process "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] EOG80ZTCK GO:0006814 84/227 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG80ZTCK GO:0016020 82/227 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80ZTCK GO:0055085 82/227 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG80ZTCK GO:0005215 82/227 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG80ZTCK GO:0008340 2/227 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG80ZTCK GO:0015141 2/227 succinate transmembrane transporter activity molecular_function "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732] EOG80ZTCK GO:0015744 2/227 succinate transport biological_process "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:0006848 2/227 pyruvate transport biological_process "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:0071422 2/227 succinate transmembrane transport biological_process "A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG80ZTCK GO:0005887 2/227 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80ZTCK GO:0015137 2/227 citrate transmembrane transporter activity molecular_function "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai] EOG80ZTCK GO:0015746 2/227 citrate transport biological_process "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG80ZTCK GO:1901475 2/227 pyruvate transmembrane transport biological_process "The directed movement of pyruvate across a membrane." [GOC:TermGenie] EOG80ZTCK GO:0050833 2/227 pyruvate transmembrane transporter activity molecular_function "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai] EOG80ZTCK GO:0000077 1/227 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG80ZTCK GO:0016323 1/227 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG80ZTCK GO:0005886 1/227 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80ZTCK GO:0010889 1/227 regulation of sequestering of triglyceride biological_process "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] EOG80ZTCK GO:0030896 1/227 checkpoint clamp complex cellular_component "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] EOG8K9DSG GO:0030604 1/15 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity molecular_function "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13720] EOG8K9DSG GO:0046872 1/15 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8K9DSG GO:0008299 1/15 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8642RT GO:0006260 29/114 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8642RT GO:0005524 28/114 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8642RT GO:0005971 28/114 ribonucleoside-diphosphate reductase complex cellular_component "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1] EOG8642RT GO:0004748 28/114 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] EOG8642RT GO:0051539 1/114 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8642RT GO:0016992 1/114 lipoate synthase activity molecular_function "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109] EOG8642RT GO:0055114 1/114 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8642RT GO:0006919 1/114 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8642RT GO:0042246 1/114 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8642RT GO:0009263 1/114 deoxyribonucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8PZMMH GO:0022008 1/95 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8K9DSN GO:0005634 27/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K9DSN GO:0005496 27/92 steroid binding molecular_function "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] EOG8K9DSN GO:0004884 27/92 ecdysteroid hormone receptor activity molecular_function "Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701] EOG8K9DSN GO:0008270 27/92 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K9DSN GO:0043565 26/92 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8K9DSN GO:0007552 1/92 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8K9DSN GO:0070491 1/92 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8K9DSN GO:0035180 1/92 larval wandering behavior biological_process "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] EOG8K9DSN GO:0007616 1/92 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8K9DSN GO:0045892 1/92 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8K9DSN GO:0006911 1/92 phagocytosis, engulfment biological_process "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] EOG8K9DSN GO:0035188 1/92 hatching biological_process "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001] EOG8K9DSN GO:0044130 1/92 negative regulation of growth of symbiont in host biological_process "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] EOG8K9DSN GO:0006914 1/92 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8K9DSN GO:0005737 1/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K9DSN GO:0018990 1/92 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8K9DSN GO:0035076 1/92 ecdysone receptor-mediated signaling pathway biological_process "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] EOG8K9DSN GO:0010002 1/92 cardioblast differentiation biological_process "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8K9DSN GO:0007298 1/92 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8K9DSN GO:0007488 1/92 histoblast morphogenesis biological_process "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] EOG8K9DSN GO:0010506 1/92 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8K9DSN GO:0001047 1/92 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG8K9DSN GO:0007517 1/92 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8K9DSN GO:0035297 1/92 regulation of Malpighian tubule diameter biological_process "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] EOG8K9DSN GO:0001225 1/92 RNA polymerase II transcription coactivator binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] EOG8K9DSN GO:0004879 1/92 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8K9DSN GO:0008340 1/92 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8K9DSN GO:0001077 1/92 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8K9DSN GO:0008362 1/92 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8K9DSN GO:0007390 1/92 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8K9DSN GO:0035073 1/92 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG8K9DSN GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8K9DSN GO:0045944 1/92 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8K9DSN GO:0030425 1/92 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8K9DSN GO:0035053 1/92 dorsal vessel heart proper cell fate commitment biological_process "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] EOG8K9DSN GO:0007291 1/92 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8K9DSN GO:0007409 1/92 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8K9DSN GO:0035206 1/92 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8K9DSN GO:0007155 1/92 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8K9DSN GO:0035193 1/92 larval central nervous system remodeling biological_process "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692] EOG8K9DSN GO:0000976 1/92 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8K9DSN GO:0005700 1/92 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8K9DSN GO:0045893 1/92 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8K9DSN GO:0035072 1/92 ecdysone-mediated induction of salivary gland cell autophagic cell death biological_process "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] EOG8K9DSN GO:0048477 1/92 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8K9DSN GO:0043065 1/92 positive regulation of apoptotic process biological_process "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8K9DSN GO:0007468 1/92 regulation of rhodopsin gene expression biological_process "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8K9DSN GO:0048813 1/92 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8K9DSN GO:0008258 1/92 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8K9DSN GO:0007561 1/92 imaginal disc eversion biological_process "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] EOG8K9DSN GO:0008231 1/92 repressor ecdysone receptor complex cellular_component "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] EOG8K9DSN GO:0007286 1/92 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8K9DSN GO:0042220 1/92 response to cocaine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl] EOG8K9DSN GO:0007443 1/92 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8K9DSN GO:0008544 1/92 epidermis development biological_process "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] EOG8K9DSN GO:0045938 1/92 positive regulation of circadian sleep/wake cycle, sleep biological_process "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] EOG8K9DSN GO:0040034 1/92 regulation of development, heterochronic biological_process "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] EOG8K9DSN GO:0007281 1/92 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8K9DSN GO:0048666 1/92 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8K9DSN GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8K9DSN GO:0046982 1/92 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8K9DSN GO:0007422 1/92 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8K9DSN GO:0008230 1/92 ecdysone receptor holocomplex cellular_component "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] EOG8K9DSN GO:0006357 1/92 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8K9DSN GO:0035075 1/92 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG8K9DSN GO:0016319 1/92 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8K9DSN GO:0008232 1/92 activator ecdysone receptor complex cellular_component "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] EOG8K9DSN GO:0048738 1/92 cardiac muscle tissue development biological_process "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] EOG8K9DSN GO:0007476 1/92 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8K9DSN GO:0016322 1/92 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8K9DSM GO:0006584 1/104 catecholamine metabolic process biological_process "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] EOG8K9DSM GO:0007126 1/104 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8K9DSM GO:0005634 1/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8K9DSM GO:0005700 1/104 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8K9DSM GO:0004500 1/104 dopamine beta-monooxygenase activity molecular_function "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120] EOG8K9DSM GO:0005737 1/104 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K9DSM GO:0005730 1/104 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8K9DSM GO:0055114 1/104 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8K9DSM GO:0005874 1/104 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8K9DSM GO:0006997 1/104 nucleus organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] EOG8K9DSM GO:0051225 1/104 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8K9DSM GO:0007067 1/104 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8K9DSM GO:0005819 1/104 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8PZMMC GO:0005509 23/104 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8PZMMC GO:0004725 2/104 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8PZMMC GO:0007009 1/104 plasma membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8PZMMC GO:0007274 1/104 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8PZMMC GO:0051693 1/104 actin filament capping biological_process "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] EOG8PZMMC GO:0016323 1/104 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8PZMMC GO:0008017 1/104 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8PZMMC GO:0031594 1/104 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8PZMMC GO:0048134 1/104 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG8PZMMC GO:0045169 1/104 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8PZMMC GO:0005938 1/104 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8PZMMC GO:0007308 1/104 oocyte construction biological_process "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] EOG8PZMMC GO:0005886 1/104 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PZMMC GO:0005794 1/104 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8PZMMC GO:0007294 1/104 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8PZMMC GO:0005811 1/104 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8PZMMC GO:0030727 1/104 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG8PZMMC GO:0050807 1/104 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG8PZMMC GO:0003779 1/104 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8PZMMC GO:0007417 1/104 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8PZMMC GO:0048790 1/104 maintenance of presynaptic active zone structure biological_process "The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] EOG8PZMMC GO:0045478 1/104 fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] EOG8PZMMC GO:0008360 1/104 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PZMMC GO:0030707 1/104 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PZMMC GO:0007026 1/104 negative regulation of microtubule depolymerization biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] EOG8PZMMC GO:0042062 1/104 long-term strengthening of neuromuscular junction biological_process "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd] EOG8PZMMC GO:0008092 1/104 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG8PZMMC GO:0045170 1/104 spectrosome cellular_component "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] EOG8PZMMC GO:0016199 1/104 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8PZMMC GO:0030721 1/104 spectrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] EOG8PZMMC GO:0008091 1/104 spectrin cellular_component "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] EOG8Z919P GO:0016500 24/92 protein-hormone receptor activity molecular_function "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] EOG8Z919P GO:0016021 24/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z919P GO:0004721 2/92 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8Z919P GO:0007564 1/92 regulation of chitin-based cuticle tanning biological_process "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] EOG8Z919P GO:0004930 1/92 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8Z919P GO:0008188 1/92 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8Z919P GO:0007186 1/92 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8Z919P GO:0050254 1/92 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8Z919P GO:0005887 1/92 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z919P GO:0001837 1/92 epithelial to mesenchymal transition biological_process "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] EOG8Z919P GO:0007218 1/92 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8K9DS5 GO:0044262 1/85 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG8K9DS5 GO:0016616 1/85 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8K9DS3 GO:0008168 21/95 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8K9DS0 GO:0005737 3/56 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K9DS0 GO:0000902 3/56 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8DNHJS GO:0000179 27/96 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] EOG8DNHJS GO:0003712 2/96 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8DNHJS GO:0005759 2/96 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8DNHJS GO:2001141 2/96 regulation of RNA biosynthetic process biological_process "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] EOG8DNHJS GO:0006390 2/96 transcription from mitochondrial promoter biological_process "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] EOG8DNHJS GO:0003723 2/96 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DNHJS GO:0005739 1/96 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DNHJS GO:0006417 1/96 regulation of translation biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8642RQ GO:0004525 29/109 ribonuclease III activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] EOG8642RQ GO:0003723 28/109 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8642RQ GO:0006396 28/109 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8642RQ GO:0004386 26/109 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8642RQ GO:0005524 26/109 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8642RQ GO:0003676 3/109 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8642RQ GO:0016891 2/109 endoribonuclease activity, producing 5'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] EOG8642RQ GO:0070883 1/109 pre-miRNA binding molecular_function "Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094] EOG8642RQ GO:0003727 1/109 single-stranded RNA binding molecular_function "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] EOG8642RQ GO:0007367 1/109 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8642RQ GO:0016443 1/109 bidentate ribonuclease III activity molecular_function "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] EOG8642RQ GO:0042078 1/109 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG8642RQ GO:0003725 1/109 double-stranded RNA binding molecular_function "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] EOG8642RQ GO:0045448 1/109 mitotic cell cycle, embryonic biological_process "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] EOG8642RQ GO:0046872 1/109 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8642RQ GO:0031054 1/109 pre-miRNA processing biological_process "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354] EOG8642RQ GO:0016246 1/109 RNA interference biological_process "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] EOG8642RQ GO:0030727 1/109 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG8642RQ GO:0033227 1/109 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8642RQ GO:0007294 1/109 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8642RQ GO:0005737 1/109 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8642RQ GO:0090501 1/109 RNA phosphodiester bond hydrolysis biological_process "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG8642RQ GO:0030422 1/109 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG8642RQ GO:0035087 1/109 siRNA loading onto RISC involved in RNA interference biological_process "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] EOG8642RQ GO:0035196 1/109 production of miRNAs involved in gene silencing by miRNA biological_process "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283] EOG8642RQ GO:0090502 1/109 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG8642RQ GO:0007279 1/109 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8642RQ GO:0016442 1/109 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG8642RQ GO:0005515 1/109 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8642RQ GO:0048813 1/109 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8J13TM GO:0043565 1/3 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RJJGB GO:0005634 15/34 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RJJGB GO:0008270 15/34 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RJJGB GO:0006351 11/34 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8RJJGB GO:0003700 11/34 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RJJGB GO:0003677 4/34 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RJJGB GO:0000981 1/34 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8RJJGB GO:0006357 1/34 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RJJGB GO:0006366 1/34 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8RJJGB GO:0003676 1/34 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DNHJH GO:0003723 23/92 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DNHJH GO:0007283 1/92 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8DNHJH GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DNHJH GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DNHJH GO:0003729 1/92 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8DNHJH GO:0004221 1/92 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG8DNHJH GO:0006397 1/92 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8DNHJH GO:0000381 1/92 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8DNHJH GO:0048025 1/92 negative regulation of mRNA splicing, via spliceosome biological_process "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] EOG8DNHJH GO:0048024 1/92 regulation of mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] EOG8Z919K GO:0032116 16/91 SMC loading complex cellular_component "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] EOG8Z919K GO:0005634 16/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z919K GO:0005654 16/91 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8Z919K GO:0000785 16/91 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8Z919K GO:0034088 16/91 maintenance of mitotic sister chromatid cohesion biological_process "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] EOG8Z919K GO:0007411 1/91 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8Z919K GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DNHJB GO:0005639 28/108 integral component of nuclear inner membrane cellular_component "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] EOG8DNHJB GO:0000166 9/108 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8DNHJB GO:0030514 1/108 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG8JHFVN GO:0007229 20/67 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8JHFVN GO:0007155 19/67 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8JHFVN GO:0016021 19/67 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JHFVN GO:0004872 14/67 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8JHFVN GO:0007275 13/67 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8JHFVN GO:0035011 1/67 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8JHFVN GO:0045886 1/67 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8JHFVN GO:0007476 1/67 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8JHFVN GO:0050839 1/67 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8JHFVN GO:0043277 1/67 apoptotic cell clearance biological_process "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] EOG8JHFVN GO:0007160 1/67 cell-matrix adhesion biological_process "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] EOG8JHFVN GO:0046716 1/67 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8JHFVN GO:0008305 1/67 integrin complex cellular_component "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] EOG8JHFVN GO:0007157 1/67 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8JHFVN GO:0042048 1/67 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8JHFVN GO:0006909 1/67 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8JHFVN GO:0016772 1/67 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8X99XX GO:0016747 25/94 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8X99XX GO:0006633 25/94 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8X99XX GO:0016740 2/94 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81RS8B GO:0016831 24/94 carboxy-lyase activity molecular_function "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] EOG81RS8B GO:0019752 24/94 carboxylic acid metabolic process biological_process "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] EOG81RS8B GO:0030170 24/94 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81RS8B GO:0008117 3/94 sphinganine-1-phosphate aldolase activity molecular_function "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] EOG81RS8B GO:0007275 1/94 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81RS8B GO:0046331 1/94 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG81RS8B GO:0005789 1/94 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG81RS8B GO:0030149 1/94 sphingolipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG81RS8B GO:0016021 1/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X99XM GO:0016021 24/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J9QDT GO:0003676 17/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J9QDT GO:0046872 17/41 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG808QQS GO:0003676 7/236 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG808QQS GO:0008270 3/236 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SN45G GO:0003682 14/229 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8SN45G GO:0006915 3/229 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8SN45G GO:0005634 3/229 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN45G GO:0003677 3/229 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SN45G GO:0008270 1/229 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84N171 GO:0004799 31/106 thymidylate synthase activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107] EOG84N171 GO:0006231 31/106 dTMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] EOG84N171 GO:0022008 1/106 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84N171 GO:0006235 1/106 dTTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732] EOG8JHFVQ GO:0046872 26/104 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JHFVQ GO:0008970 1/104 phosphatidylcholine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] EOG8JHFVQ GO:0052739 1/104 phosphatidylserine 1-acylhydrolase activity molecular_function "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034] EOG8JHFVQ GO:0052740 1/104 1-acyl-2-lysophosphatidylserine acylhydrolase activity molecular_function "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] EOG8X99XB GO:0016020 29/97 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8X99XB GO:0016758 29/97 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8X99XB GO:0005975 29/97 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8W3W32 GO:0005777 23/92 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG837TV3 GO:0035556 22/80 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG837TV3 GO:0004143 22/80 diacylglycerol kinase activity molecular_function "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] EOG837TV3 GO:0005524 22/80 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG837TV3 GO:0003951 22/80 NAD+ kinase activity molecular_function "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] EOG837TV3 GO:0007205 22/80 protein kinase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] EOG837TV3 GO:0016310 1/80 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8S4RW9 GO:0005856 28/109 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8S4RW9 GO:0007165 20/109 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG81VNGP GO:0007165 36/216 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG81VNGP GO:0004623 3/216 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG81VNGP GO:0016651 1/216 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG81VNGP GO:0005886 1/216 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81VNGP GO:0007016 1/216 cytoskeletal anchoring at plasma membrane biological_process "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] EOG81VNGP GO:0045169 1/216 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG81VNGP GO:0045170 1/216 spectrosome cellular_component "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] EOG81VNGP GO:0008092 1/216 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG81VNGP GO:0022900 1/216 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG8NS5R7 GO:0007018 11/52 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8NS5R7 GO:0003777 11/52 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8NS5R7 GO:0030286 8/52 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8NS5R7 GO:0005524 5/52 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NS5R7 GO:0016887 3/52 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8NS5R7 GO:0008270 1/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NS5R7 GO:0000166 1/52 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NS5R7 GO:0042623 1/52 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8NS5R7 GO:0006200 1/52 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8NS5R7 GO:0004842 1/52 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG83JFKT GO:0006139 19/56 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG83JFKT GO:0019205 19/56 nucleobase-containing compound kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] EOG83JFKT GO:0005524 19/56 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8B8MVT GO:0003676 7/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B8MVT GO:0015074 7/18 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG808QP6 GO:0003676 1/31 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG808QP6 GO:0046872 1/31 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG808QQX GO:0005576 24/38 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG808QQX GO:0032504 1/38 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG83JFKH GO:0008474 26/91 palmitoyl-(protein) hydrolase activity molecular_function "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] EOG83JFKH GO:0006464 25/91 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG83JFKH GO:0002084 1/91 protein depalmitoylation biological_process "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] EOG83JFKH GO:0005764 1/91 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG83JFKH GO:0006898 1/91 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG83JFKH GO:0006897 1/91 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG83JFKH GO:0008340 1/91 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG83JFKG GO:0008270 26/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83JFKG GO:0016491 24/93 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG83JFKG GO:0019166 2/93 trans-2-enoyl-CoA reductase (NADPH) activity molecular_function "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] EOG83JFKG GO:0006633 1/93 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG83JFKG GO:0005739 1/93 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG83JFKG GO:0006631 1/93 fatty acid metabolic process biological_process "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] EOG83JFKG GO:0005875 1/93 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG870WXZ GO:0080130 1/6 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] EOG870WXZ GO:0030170 1/6 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG870WXZ GO:0009058 1/6 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG870WXZ GO:0006520 1/6 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG870WXZ GO:0004069 1/6 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] EOG8ZSCJW GO:0003735 27/96 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8ZSCJW GO:0006412 27/96 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8ZSCJW GO:0005840 27/96 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8ZSCJW GO:0019843 3/96 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8ZSCJW GO:0000228 1/96 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8ZSCJW GO:0005730 1/96 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8ZSCJW GO:0022008 1/96 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8ZSCJW GO:0000022 1/96 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8ZSCJW GO:0007052 1/96 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8ZSCJW GO:0005737 1/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GTNV8 GO:0003676 34/211 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GTNV8 GO:0008270 27/211 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GTNV8 GO:0015074 11/211 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8GTNV8 GO:0003723 6/211 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GTNV8 GO:0005198 6/211 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8GTNV8 GO:0005882 6/211 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8GTNV8 GO:0003964 6/211 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8GTNV8 GO:0005524 1/211 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GTNV8 GO:0005737 1/211 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GTNV8 GO:0004190 1/211 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8GTNV8 GO:0006457 1/211 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG870WXM GO:0008892 21/89 guanine deaminase activity molecular_function "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] EOG870WXM GO:0008270 21/89 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG870WXM GO:0006147 21/89 guanine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] EOG870WXM GO:0004153 1/89 dihydropterin deaminase activity molecular_function "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] EOG870WXM GO:0016021 1/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG870WXM GO:0004930 1/89 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG870WXM GO:0016810 1/89 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] EOG870WXM GO:0006726 1/89 eye pigment biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] EOG870WXM GO:0051067 1/89 dihydropteridine metabolic process biological_process "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [CHEBI:30156, GOC:ai] EOG870WXM GO:0046098 1/89 guanine metabolic process biological_process "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] EOG870WXK GO:0004197 1/57 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG870WXK GO:0005515 1/57 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG870WXK GO:0015459 1/57 potassium channel regulator activity molecular_function "Modulates the activity of a potassium channel." [GOC:mah] EOG89KJ5D GO:0008898 38/128 S-adenosylmethionine-homocysteine S-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] EOG89KJ5K GO:0008233 1/4 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG851H56 GO:0005852 28/90 eukaryotic translation initiation factor 3 complex cellular_component "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] EOG851H56 GO:0003743 28/90 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG851H56 GO:0006446 26/90 regulation of translational initiation biological_process "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] EOG851H56 GO:0001731 26/90 formation of translation preinitiation complex biological_process "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] EOG851H56 GO:0016282 26/90 eukaryotic 43S preinitiation complex cellular_component "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] EOG851H56 GO:0033290 26/90 eukaryotic 48S preinitiation complex cellular_component "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] EOG851H56 GO:0051726 1/90 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG851H56 GO:0043231 1/90 intracellular membrane-bounded organelle cellular_component "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] EOG851H56 GO:0006413 1/90 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG851H56 GO:0006909 1/90 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG851H56 GO:0048812 1/90 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG851H52 GO:0003824 3/14 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG851H52 GO:0030170 3/14 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8ZSCJC GO:0003824 31/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8ZSCJC GO:0006777 8/119 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG8ZSCJC GO:0003723 1/119 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8ZSCJC GO:0004604 1/119 phosphoadenylyl-sulfate reductase (thioredoxin) activity molecular_function "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11727] EOG8ZSCJC GO:0003919 1/119 FMN adenylyltransferase activity molecular_function "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17240] EOG8B2WF9 GO:0005739 3/84 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8B2WF9 GO:0042742 1/84 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8GTNVM GO:0016020 8/43 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GTNVM GO:0007264 8/43 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8GTNVM GO:0005525 8/43 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8GTNVM GO:0006184 8/43 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8GTNVM GO:0004767 2/43 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG851H5H GO:0008270 15/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZSCJ5 GO:0003677 1/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RJJGV GO:0005525 49/162 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8RJJGV GO:0007264 49/162 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8RJJGV GO:0015031 47/162 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8RJJGV GO:0003924 2/162 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8RJJGV GO:0055037 2/162 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG8RJJGV GO:0043025 2/162 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8RJJGV GO:0006184 2/162 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8RJJGV GO:0045202 2/162 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8RJJGV GO:0004767 1/162 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8RJJGV GO:0045175 1/162 basal protein localization biological_process "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] EOG8RJJGV GO:0005737 1/162 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RJJGV GO:0008021 1/162 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8RJJGV GO:0046331 1/162 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RJJGV GO:0031254 1/162 cell trailing edge cellular_component "The area of a motile cell opposite to the direction of movement." [GOC:pg] EOG8RJJGV GO:0007295 1/162 growth of a germarium-derived egg chamber biological_process "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8RJJGV GO:0045178 1/162 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8B2WF4 GO:0016021 1/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B2WF4 GO:0004930 1/17 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8M0HH2 GO:0003676 7/156 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M0HH7 GO:0003677 18/140 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8M0HH7 GO:0015074 16/140 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8M0HH7 GO:0006310 16/140 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8M0HH7 GO:0008270 3/140 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M0HH7 GO:0005634 2/140 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M0HH7 GO:0003964 2/140 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8M0HH7 GO:0051607 2/140 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8M0HH7 GO:0005739 2/140 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8M0HH7 GO:0004871 2/140 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8M0HH7 GO:0003723 2/140 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8M0HH7 GO:0005975 1/140 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8M0HH7 GO:0016616 1/140 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8M0HH7 GO:0003676 1/140 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JDKQ5 GO:0008052 1/105 sensory organ boundary specification biological_process "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] EOG8JDKQ5 GO:0005634 1/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JDKQ5 GO:0048813 1/105 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8JDKQ5 GO:0007423 1/105 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8JDKQ5 GO:0006351 1/105 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8JDKQ5 GO:0046982 1/105 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8JDKQ5 GO:0006355 1/105 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8JDKQ5 GO:0016360 1/105 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG851H5R GO:0006950 1/105 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8GTNVW GO:0005615 233/444 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8GTNVW GO:0010951 13/444 negative regulation of endopeptidase activity biological_process "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] EOG8GTNVW GO:0004867 13/444 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8GTNVW GO:0016740 13/444 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8GTNVW GO:0030162 12/444 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8GTNVW GO:0045861 10/444 negative regulation of proteolysis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] EOG8GTNVW GO:0008233 8/444 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8GTNVW GO:0032504 7/444 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8GTNVW GO:0000155 6/444 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8GTNVW GO:0016020 6/444 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GTNVW GO:0019732 1/444 antifungal humoral response biological_process "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8GTNVW GO:0008063 1/444 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8GTNVW GO:0002784 1/444 regulation of antimicrobial peptide production biological_process "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] EOG8GTNVW GO:0003677 1/444 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GTNVW GO:0005576 1/444 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GTNVW GO:0006281 1/444 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8GTNVW GO:0050829 1/444 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8GTNVW GO:0060570 1/444 negative regulation of peptide hormone processing biological_process "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] EOG8GTNVW GO:0006955 1/444 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8GTNVW GO:0004869 1/444 cysteine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] EOG8GTNVW GO:0010955 1/444 negative regulation of protein processing biological_process "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] EOG8GTNVW GO:0042562 1/444 hormone binding molecular_function "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] EOG8GTNVW GO:0045751 1/444 negative regulation of Toll signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8GTNVW GO:0050832 1/444 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8PRW71 GO:0016021 1/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83JFK9 GO:0006544 28/99 glycine metabolic process biological_process "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] EOG83JFK9 GO:0006563 28/99 L-serine metabolic process biological_process "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] EOG83JFK9 GO:0030170 28/99 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG83JFK9 GO:0004372 28/99 glycine hydroxymethyltransferase activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] EOG83JFK9 GO:0035999 25/99 tetrahydrofolate interconversion biological_process "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] EOG83JFK9 GO:0008168 7/99 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG83JFK9 GO:0048149 1/99 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG86Q97F GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86Q97F GO:0004326 1/10 tetrahydrofolylpolyglutamate synthase activity molecular_function "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] EOG86Q97F GO:0016874 1/10 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG86Q97F GO:0009058 1/10 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG83JFK0 GO:0004075 4/19 biotin carboxylase activity molecular_function "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] EOG83JFK0 GO:0046872 4/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83JFK0 GO:0005524 4/19 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83JFK0 GO:0004658 1/19 propionyl-CoA carboxylase activity molecular_function "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] EOG83JFK2 GO:0016772 13/83 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG83JFK2 GO:0003676 2/83 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83JFK2 GO:0046872 1/83 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XD667 GO:0016020 17/113 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XD667 GO:0016757 15/113 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8XD667 GO:0033829 12/113 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] EOG8XD667 GO:0030173 10/113 integral component of Golgi membrane cellular_component "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] EOG8XD667 GO:0007389 9/113 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8XD667 GO:0006493 1/113 protein O-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] EOG8XD667 GO:0001745 1/113 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8XD667 GO:0046872 1/113 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XD667 GO:0007476 1/113 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8XD667 GO:0008593 1/113 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8XD667 GO:0005794 1/113 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8XD667 GO:0006004 1/113 fucose metabolic process biological_process "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] EOG8XD667 GO:0005795 1/113 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8XD667 GO:0048190 1/113 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8XD667 GO:0007451 1/113 dorsal/ventral lineage restriction, imaginal disc biological_process "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] EOG8XD667 GO:0036011 1/113 imaginal disc-derived leg segmentation biological_process "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] EOG8XD667 GO:0045746 1/113 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8XD667 GO:0007219 1/113 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8XD667 GO:0007450 1/113 dorsal/ventral pattern formation, imaginal disc biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] EOG8XD667 GO:0007293 1/113 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8XD667 GO:0035017 1/113 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG8XD667 GO:0008375 1/113 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG8XD667 GO:0008587 1/113 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8XD667 GO:0008194 1/113 UDP-glycosyltransferase activity molecular_function "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] EOG8XD667 GO:0048477 1/113 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8XD667 GO:0048749 1/113 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8XD667 GO:0001708 1/113 cell fate specification biological_process "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] EOG8XD667 GO:0005797 1/113 Golgi medial cisterna cellular_component "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] EOG8XD667 GO:0005783 1/113 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8XD667 GO:0036099 1/113 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG837TVJ GO:0016021 29/62 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG837TVJ GO:0004930 28/62 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG837TVJ GO:0018298 26/62 protein-chromophore linkage biological_process "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] EOG837TVJ GO:0009881 25/62 photoreceptor activity molecular_function "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] EOG837TVJ GO:0007601 22/62 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG837TVJ GO:0007602 22/62 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG837TVJ GO:0009584 1/62 detection of visible light biological_process "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG837TVJ GO:0007186 1/62 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG837TVJ GO:0008020 1/62 G-protein coupled photoreceptor activity molecular_function "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] EOG8M3CRQ GO:0005743 25/81 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8M3CRQ GO:0006120 25/81 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG8M3CRQ GO:0008137 25/81 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8M3CRQ GO:0070469 20/81 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8M3CRQ GO:0016021 1/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M3CRQ GO:0004930 1/81 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FBM94 GO:0016597 11/116 amino acid binding molecular_function "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] EOG8FBM94 GO:0008152 8/116 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8FBM94 GO:0004794 6/116 L-threonine ammonia-lyase activity molecular_function "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] EOG8FBM94 GO:0006567 4/116 threonine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8FBM94 GO:0003824 1/116 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8BGC90 GO:0008270 1/53 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BGC90 GO:0003676 1/53 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PZMQ3 GO:0006950 1/8 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8M0HFS GO:0030170 10/82 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8M0HFS GO:0003824 10/82 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QC3M1 GO:0006396 30/118 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8QC3M1 GO:0003723 30/118 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8QC3M1 GO:0004000 29/118 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8QC3M1 GO:0003726 2/118 double-stranded RNA adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] EOG8QC3M1 GO:0008344 1/118 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8QC3M1 GO:0003824 1/118 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QC3M1 GO:0042752 1/118 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG8QC3M1 GO:0003725 1/118 double-stranded RNA binding molecular_function "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] EOG8QC3M1 GO:0007626 1/118 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8QC3M1 GO:0006397 1/118 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8QC3M1 GO:0005272 1/118 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8QC3M1 GO:0046872 1/118 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QC3M1 GO:0005622 1/118 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8QC3M1 GO:0009408 1/118 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8QC3M1 GO:0006979 1/118 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8QC3M1 GO:0016556 1/118 mRNA modification biological_process "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] EOG8QC3M1 GO:0009451 1/118 RNA modification biological_process "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] EOG8QC3M1 GO:0016020 1/118 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QC3M1 GO:0042391 1/118 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8QC3M1 GO:0045475 1/118 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8QC3M1 GO:0008049 1/118 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8QC3M1 GO:0006382 1/118 adenosine to inosine editing biological_process "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] EOG8QC3M1 GO:0030534 1/118 adult behavior biological_process "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] EOG8QC3M1 GO:0004525 1/118 ribonuclease III activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] EOG8QC3M1 GO:0001666 1/118 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8M0HFV GO:0004842 1/49 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8B5RMC GO:0046872 1/75 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TQPQQ GO:0035613 1/76 RNA stem-loop binding molecular_function "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] EOG8TQPQQ GO:0035368 1/76 selenocysteine insertion sequence binding molecular_function "Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958] EOG8TQPQQ GO:0001514 1/76 selenocysteine incorporation biological_process "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] EOG8TQPQQ GO:0030529 1/76 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8TQPQV GO:0016021 21/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TQPQW GO:0055114 5/70 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8TQPQW GO:0009186 5/70 deoxyribonucleoside diphosphate metabolic process biological_process "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG8TQPQW GO:0015074 1/70 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8TQPQW GO:0003676 1/70 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GJH GO:0031932 27/100 TORC2 complex cellular_component "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787] EOG883GJH GO:0031929 27/100 TOR signaling biological_process "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] EOG883GJH GO:0048813 1/100 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG883GJH GO:0006974 1/100 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG883GJH GO:0051124 1/100 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG89360G GO:0003676 70/406 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89360G GO:0005634 11/406 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89360G GO:0003700 9/406 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG89360G GO:0003707 9/406 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG89360G GO:0006351 8/406 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG89360G GO:0046872 3/406 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89360G GO:0003964 2/406 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG89360G GO:0003723 2/406 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG89360G GO:0005506 1/406 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG89360G GO:0042981 1/406 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG89360G GO:0003677 1/406 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89360G GO:0008270 1/406 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89360G GO:0019058 1/406 viral life cycle biological_process "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] EOG89360G GO:0005622 1/406 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89360G GO:0006886 1/406 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG83V28P GO:0046872 18/65 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83V28P GO:0003676 17/65 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JT2K9 GO:0005634 21/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JT2K9 GO:0006886 18/94 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8JT2K9 GO:0005506 2/94 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8JT2K9 GO:0020037 2/94 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8JT2K9 GO:0016705 2/94 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8JT2K9 GO:0006810 1/94 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8JT2K9 GO:0004497 1/94 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8B5RMR GO:0003677 2/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B5RMR GO:0006355 2/4 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8B5RMR GO:0000156 2/4 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8TQPQF GO:0015078 27/101 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8TQPQF GO:0015991 27/101 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8TQPQF GO:0033180 26/101 proton-transporting V-type ATPase, V1 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG8TQPQF GO:0016787 2/101 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8TQPQF GO:0009116 1/101 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8TQPQF GO:0003824 1/101 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8TQPQF GO:0000221 1/101 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] EOG8TQPQF GO:0015992 1/101 proton transport biological_process "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG8TQPQF GO:0033181 1/101 plasma membrane proton-transporting V-type ATPase complex cellular_component "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] EOG8TQPQF GO:0005886 1/101 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG886BTF GO:0070403 23/91 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG886BTF GO:0006476 20/91 protein deacetylation biological_process "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] EOG886BTF GO:0008270 20/91 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG886BTF GO:0016811 19/91 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG886BTF GO:0048813 1/91 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG886BTF GO:0016575 1/91 histone deacetylation biological_process "The modification of histones by removal of acetyl groups." [GOC:ai] EOG886BTF GO:0008340 1/91 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG886BTF GO:0017136 1/91 NAD-dependent histone deacetylase activity molecular_function "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551] EOG83V28F GO:0016020 9/33 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83V28F GO:0005524 9/33 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83V28F GO:0017038 9/33 protein import biological_process "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] EOG83V28F GO:0003676 7/33 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83V28F GO:0004386 7/33 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG83V28F GO:0006605 4/33 protein targeting biological_process "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] EOG86MF0P GO:0006950 1/31 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8TQPQ3 GO:0006139 4/47 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG8TQPQ3 GO:0005524 4/47 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TQPQ3 GO:0019205 4/47 nucleobase-containing compound kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] EOG8TQPQ3 GO:0017111 1/47 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8TQPQ1 GO:0005622 38/108 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8TQPQ1 GO:0005085 38/108 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8TQPQ1 GO:0007264 38/108 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8TQPQ1 GO:0051056 32/108 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8TQPQ1 GO:0016319 1/108 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8TQPQ1 GO:0008360 1/108 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8CZDZX GO:0003677 17/2665 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CZDZX GO:0015074 6/2665 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CZDZX GO:0004803 6/2665 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8CZDZX GO:0006313 6/2665 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8CZDZX GO:0006355 3/2665 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CZDZX GO:0003676 3/2665 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CZDZX GO:0016021 1/2665 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CZDZX GO:0015171 1/2665 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8CZDZX GO:0046872 1/2665 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CZDZX GO:0008270 1/2665 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81NX39 GO:0004493 1/6 methylmalonyl-CoA epimerase activity molecular_function "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20556] EOG8TQPQ5 GO:0016772 2/16 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8TQPQ5 GO:0016310 2/16 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8TQPQ9 GO:0005615 15/92 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8TQPQ9 GO:0008233 5/92 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8TQPQ9 GO:0016740 3/92 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG886BT3 GO:0016021 44/166 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BT3 GO:0004930 37/166 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG886BT3 GO:0050254 5/166 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG886BT3 GO:0005000 4/166 vasopressin receptor activity molecular_function "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] EOG886BT3 GO:0016500 3/166 protein-hormone receptor activity molecular_function "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] EOG886BT3 GO:0055088 1/166 lipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] EOG886BT3 GO:0070328 1/166 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG886BT3 GO:0016042 1/166 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG886BT3 GO:0097004 1/166 adipokinetic hormone binding molecular_function "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG886BT3 GO:0097003 1/166 adipokinetic hormone receptor activity molecular_function "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] EOG886BT3 GO:0033500 1/166 carbohydrate homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] EOG886BT3 GO:0005887 1/166 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BT3 GO:0007218 1/166 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG886BT3 GO:0008188 1/166 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG886BT3 GO:0007186 1/166 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG886BT1 GO:0005975 8/40 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG886BT1 GO:0008810 5/40 cellulase activity molecular_function "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] EOG886BT1 GO:0030247 3/40 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG886BT1 GO:0004553 3/40 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8JT2KB GO:0005525 1/37 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8JT2KB GO:0007264 1/37 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG81VNJP GO:0008061 4/17 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG81VNJP GO:0005576 4/17 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81VNJP GO:0006030 4/17 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8PZMQG GO:0072546 24/77 ER membrane protein complex cellular_component "A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, PMID:19325107] EOG8K0T3Z GO:0015940 1/6 pantothenate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] EOG8K0T3Z GO:0006523 1/6 alanine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] EOG8K0T3Z GO:0004068 1/6 aspartate 1-decarboxylase activity molecular_function "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] EOG8K0T3Z GO:0004592 1/6 pantoate-beta-alanine ligase activity molecular_function "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] EOG8VQD4D GO:0003700 1/7 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8VQD4D GO:0000156 1/7 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8VQD4D GO:0003993 1/7 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8VQD4D GO:0016021 1/7 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VQD4D GO:0055085 1/7 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8VQD4D GO:0003677 1/7 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QRKJ1 GO:0005524 42/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QRKJ1 GO:0004674 36/90 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8QRKJ1 GO:0004672 4/90 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QRKJ1 GO:0006468 2/90 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8QRKJ1 GO:0004702 2/90 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8QRKJ1 GO:0023014 2/90 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8QRKJ1 GO:0030165 1/90 PDZ domain binding molecular_function "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] EOG8QRKJ1 GO:0004697 1/90 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8QRKJ1 GO:0030177 1/90 positive regulation of Wnt signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] EOG8QRKJ1 GO:0030496 1/90 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8QRKJ1 GO:0004709 1/90 MAP kinase kinase kinase activity molecular_function "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] EOG8QRKJ1 GO:0005813 1/90 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8QRKJ1 GO:0031647 1/90 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8QRKJ1 GO:0048812 1/90 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8QRKJ1 GO:0007088 1/90 regulation of mitotic nuclear division biological_process "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8QRKJ1 GO:0005737 1/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZCWKV GO:0004055 1/3 argininosuccinate synthase activity molecular_function "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] EOG8ZCWKV GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZCWKV GO:0006526 1/3 arginine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732] EOG8QNQ99 GO:0008286 1/92 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG8QNQ99 GO:0005886 1/92 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QNQ99 GO:0030730 1/92 sequestering of triglyceride biological_process "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] EOG8QNQ99 GO:0007398 1/92 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8QNQ99 GO:0007422 1/92 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8QNQ99 GO:0006629 1/92 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8QNQ99 GO:0035091 1/92 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG8QNQ99 GO:2001020 1/92 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8QNQ99 GO:0045464 1/92 R8 cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] EOG8QNQ99 GO:0008152 1/92 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8QNQ99 GO:0010314 1/92 phosphatidylinositol-5-phosphate binding molecular_function "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] EOG8QNQ99 GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QNQ99 GO:0001708 1/92 cell fate specification biological_process "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] EOG8323DG GO:0008270 9/63 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8323DG GO:0003755 1/63 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8323DG GO:0006457 1/63 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8TTK3J GO:0046872 1/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TTK3J GO:0003676 1/21 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S1WSH GO:0003824 1/3 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S1WSH GO:0006777 1/3 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG8323DM GO:0045454 24/83 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8323DM GO:0003756 3/83 protein disulfide isomerase activity molecular_function "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] EOG8323DM GO:0005783 1/83 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8323DM GO:0034976 1/83 response to endoplasmic reticulum stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] EOG8323DM GO:0016021 1/83 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8323DM GO:0006457 1/83 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8QNQ95 GO:0004672 5/42 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QNQ95 GO:0033867 1/42 Fas-activated serine/threonine kinase activity molecular_function "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] EOG8323DK GO:0007298 1/92 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8323DK GO:0045211 1/92 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8323DK GO:0035003 1/92 subapical complex cellular_component "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] EOG8323DK GO:0008582 1/92 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8323DK GO:0007163 1/92 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8H1DBH GO:0006511 68/146 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8H1DBH GO:0016301 5/146 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8H1DBH GO:0022008 2/146 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8H1DBH GO:0005515 2/146 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8H1DBH GO:0016874 2/146 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8H1DBH GO:0046627 1/146 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8H1DBH GO:0007095 1/146 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8H1DBH GO:0004842 1/146 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8H1DBH GO:0016322 1/146 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8H1DBH GO:0051298 1/146 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8H1DBH GO:0010824 1/146 regulation of centrosome duplication biological_process "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] EOG8H1DBH GO:0005875 1/146 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8H1DBH GO:0030261 1/146 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8H1DBH GO:0042023 1/146 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8H1DBH GO:0005813 1/146 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8H1DBH GO:0031647 1/146 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8H1DBH GO:0045931 1/146 positive regulation of mitotic cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8H1DBH GO:0007067 1/146 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8H1DBH GO:0019005 1/146 SCF ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] EOG8H1DBH GO:0005819 1/146 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG866Z0X GO:0005214 1/54 structural constituent of chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG866Z0X GO:0016476 1/54 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG866Z0X GO:0007160 1/54 cell-matrix adhesion biological_process "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] EOG866Z0X GO:0016324 1/54 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG866Z0X GO:0003383 1/54 apical constriction biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG866Z0X GO:0007015 1/54 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8RNDPR GO:0016787 2/90 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8RNDPR GO:0005576 1/90 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RNDPR GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RNDPR GO:0007155 1/90 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8RNDPR GO:0005840 1/90 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8RNDPR GO:0008039 1/90 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8RNDPR GO:0016020 1/90 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M9473 GO:0004725 1/62 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG82FW0K GO:0016740 9/186 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG82FW0K GO:0004364 2/186 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG82FW0K GO:0005811 1/186 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG82FW0K GO:0050220 1/186 prostaglandin-E synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896] EOG8RNDPG GO:0016620 60/211 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8RNDPG GO:0001758 5/211 retinal dehydrogenase activity molecular_function "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] EOG8RNDPG GO:0004029 2/211 aldehyde dehydrogenase (NAD) activity molecular_function "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] EOG8RNDPG GO:0045471 1/211 response to ethanol biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] EOG8RNDPG GO:0008774 1/211 acetaldehyde dehydrogenase (acetylating) activity molecular_function "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] EOG8RNDPG GO:0005811 1/211 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8RNDPG GO:0005739 1/211 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8RNDPG GO:0005737 1/211 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82FW0V GO:0008270 7/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RNDPB GO:0016021 38/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RNDPB GO:0008270 1/99 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TF30N GO:0016779 10/94 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8TF30N GO:0009058 9/94 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8TF30N GO:0003743 2/94 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8TF30N GO:0071456 1/94 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8TF30N GO:0005829 1/94 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8TF30N GO:0005851 1/94 eukaryotic translation initiation factor 2B complex cellular_component "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] EOG8TF30N GO:0050518 1/94 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity molecular_function "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13432] EOG8TF30N GO:0006413 1/94 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8TF30N GO:0008878 1/94 glucose-1-phosphate adenylyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12123] EOG8PK4QS GO:0008270 1/72 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WDGS1 GO:0003824 24/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8WDGS1 GO:0003735 1/89 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8WDGS1 GO:0005840 1/89 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8WDGS1 GO:0008061 1/89 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WDGS1 GO:0005576 1/89 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8WDGS1 GO:0006030 1/89 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WDGS1 GO:0006412 1/89 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WDGS0 GO:0010629 1/97 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8WDGS0 GO:0042826 1/97 histone deacetylase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] EOG8WDGS0 GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WDGS0 GO:0046872 1/97 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M947T GO:0003735 1/6 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8M947T GO:0005840 1/6 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8M947T GO:0006412 1/6 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8KM1J7 GO:0030414 16/65 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8KM1J7 GO:0008233 1/65 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG854CDM GO:0005544 89/289 calcium-dependent phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] EOG854CDM GO:0005509 89/289 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG854CDM GO:0003779 3/289 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG854CDM GO:0061467 1/289 basolateral protein localization biological_process "Any process in which a protein is transported to, or maintained in, basolateral regions of the cell." [GOC:dph] EOG854CDM GO:0003677 1/289 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG854CDM GO:0006351 1/289 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG854CDM GO:0048190 1/289 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG854CDM GO:0007155 1/289 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG854CDM GO:0030011 1/289 maintenance of cell polarity biological_process "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG854CDM GO:0008360 1/289 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG854CDM GO:0030507 1/289 spectrin binding molecular_function "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] EOG854CDM GO:0046872 1/289 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG854CDM GO:0010797 1/289 regulation of multivesicular body size involved in endosome transport biological_process "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] EOG854CDM GO:0032509 1/289 endosome transport via multivesicular body sorting pathway biological_process "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] EOG854CDM GO:0005515 1/289 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG854CDM GO:0005634 1/289 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG854CDM GO:0016020 1/289 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG854CDM GO:0012505 1/289 endomembrane system cellular_component "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] EOG854CDM GO:0005938 1/289 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG854CDM GO:0006357 1/289 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG80GG4X GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80GG4X GO:0003676 1/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PK4Q1 GO:0003676 4/37 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8PK4Q1 GO:0008270 4/37 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PK4Q1 GO:0005634 4/37 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PK4Q1 GO:0046872 1/37 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PK4Q2 GO:0005525 24/99 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8PK4Q2 GO:0007264 24/99 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8PK4Q2 GO:0005622 23/99 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8PK4Q2 GO:0016020 23/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PK4Q2 GO:0035298 1/99 regulation of Malpighian tubule size biological_process "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf] EOG8PK4Q2 GO:0090303 1/99 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8PK4Q2 GO:0000281 1/99 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8PK4Q2 GO:0007368 1/99 determination of left/right symmetry biological_process "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] EOG8PK4Q2 GO:0007254 1/99 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8PK4Q2 GO:0007010 1/99 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8PK4Q2 GO:0030866 1/99 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8PK4Q2 GO:0007349 1/99 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8PK4Q2 GO:0007164 1/99 establishment of tissue polarity biological_process "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] EOG8PK4Q2 GO:0007374 1/99 posterior midgut invagination biological_process "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] EOG8PK4Q2 GO:0005856 1/99 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8PK4Q2 GO:0016318 1/99 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8PK4Q2 GO:0007601 1/99 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8PK4Q2 GO:0042060 1/99 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8PK4Q2 GO:0051493 1/99 regulation of cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] EOG8PK4Q2 GO:0007391 1/99 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8PK4Q2 GO:0007395 1/99 dorsal closure, spreading of leading edge cells biological_process "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] EOG8PK4Q2 GO:0007298 1/99 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8PK4Q2 GO:0016476 1/99 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8PK4Q2 GO:0007435 1/99 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8PK4Q2 GO:0005737 1/99 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PK4Q2 GO:0007370 1/99 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG8PK4Q2 GO:0035149 1/99 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG8PK4Q2 GO:0035099 1/99 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8PK4Q2 GO:0007369 1/99 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8PK4Q2 GO:0005515 1/99 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8PK4Q2 GO:0045179 1/99 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8PK4Q2 GO:0001737 1/99 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8PK4Q2 GO:0030036 1/99 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8PK4Q2 GO:0007173 1/99 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8PK4Q2 GO:0070451 1/99 cell hair cellular_component "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] EOG8PK4Q2 GO:0048813 1/99 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8PK4Q2 GO:0035006 1/99 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8PK4Q2 GO:0003924 1/99 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8PK4Q2 GO:0051489 1/99 regulation of filopodium assembly biological_process "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG8PK4Q2 GO:0071902 1/99 positive regulation of protein serine/threonine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] EOG8PK4Q2 GO:0016055 1/99 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8PK4Q2 GO:0090254 1/99 cell elongation involved in imaginal disc-derived wing morphogenesis biological_process "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8PK4Q2 GO:0007015 1/99 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8PK4Q2 GO:0007377 1/99 germ-band extension biological_process "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] EOG8PK4Q2 GO:0035317 1/99 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG8PK4Q2 GO:0045184 1/99 establishment of protein localization biological_process "The directed movement of a protein to a specific location." [GOC:bf] EOG8PK4Q2 GO:0007411 1/99 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8PK4Q2 GO:0070252 1/99 actin-mediated cell contraction biological_process "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] EOG8PK4Q2 GO:0008045 1/99 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8PK4Q2 GO:0034613 1/99 cellular protein localization biological_process "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] EOG8PK4Q2 GO:0008354 1/99 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8PK4Q2 GO:0035147 1/99 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG8PK4Q2 GO:0001745 1/99 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8PK4Q2 GO:0007405 1/99 neuroblast proliferation biological_process "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] EOG8PK4Q2 GO:0006897 1/99 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8PK4Q2 GO:0005938 1/99 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8PK4Q2 GO:0051017 1/99 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG8PK4Q2 GO:0001736 1/99 establishment of planar polarity biological_process "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] EOG8PK4Q2 GO:0005886 1/99 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PK4Q2 GO:0006184 1/99 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8PK4Q2 GO:0010004 1/99 gastrulation involving germ band extension biological_process "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8PK4Q2 GO:0007422 1/99 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8PK4Q2 GO:0008347 1/99 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8PK4Q2 GO:0030589 1/99 pseudocleavage involved in syncytial blastoderm formation biological_process "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8PK4Q2 GO:0004767 1/99 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8PK4Q2 GO:0050770 1/99 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG8PK4Q2 GO:0031532 1/99 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8PK4Q2 GO:0019900 1/99 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG8PK4Q2 GO:0070593 1/99 dendrite self-avoidance biological_process "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] EOG8PK4Q2 GO:0035277 1/99 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8PK4Q2 GO:0007424 1/99 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8PK4Q2 GO:0007480 1/99 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8PK4Q2 GO:0006974 1/99 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8PK4Q2 GO:0035159 1/99 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG8PK4Q2 GO:0045199 1/99 maintenance of epithelial cell apical/basal polarity biological_process "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf] EOG8PK4Q2 GO:0046663 1/99 dorsal closure, leading edge cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138] EOG83R61F GO:0031409 16/120 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG83R61F GO:0005576 11/120 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG83R61F GO:0005215 4/120 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG83R61F GO:0036094 3/120 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG83R61F GO:0030682 3/120 evasion or tolerance of host defense response biological_process "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] EOG83R61F GO:0005501 2/120 retinoid binding molecular_function "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] EOG83R61D GO:0016021 17/75 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83R61D GO:0007015 1/75 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG83R61D GO:0015629 1/75 actin cytoskeleton cellular_component "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] EOG83R61D GO:0008335 1/75 female germline ring canal stabilization biological_process "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] EOG83R61D GO:0005635 1/75 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG83R61D GO:0040011 1/75 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG83R61D GO:0060361 1/75 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG83R61D GO:0051640 1/75 organelle localization biological_process "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] EOG83R61D GO:0016477 1/75 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG83R61D GO:0007498 1/75 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG83R61D GO:0007303 1/75 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG83R61D GO:0040023 1/75 establishment of nucleus localization biological_process "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] EOG83R61D GO:0031965 1/75 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG83R61D GO:0008092 1/75 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG83R61D GO:0007519 1/75 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG83R61D GO:0003779 1/75 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG83R61D GO:0007523 1/75 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG83R61D GO:0030018 1/75 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG83R61D GO:0048471 1/75 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG83R61D GO:0005737 1/75 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8H1DB9 GO:0035556 1/6 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8H1DB9 GO:0046872 1/6 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H1DB9 GO:0005622 1/6 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8H1DB7 GO:0008168 5/11 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8V9X4R GO:0006281 27/107 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8V9X4R GO:0000723 27/107 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8V9X4R GO:0005524 22/107 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V9X4R GO:0005634 16/107 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V9X4R GO:0003677 16/107 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V9X4R GO:0000002 16/107 mitochondrial genome maintenance biological_process "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] EOG8V9X4R GO:0043141 16/107 ATP-dependent 5'-3' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] EOG8V9X4R GO:0005739 16/107 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8V9X4R GO:0006310 16/107 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8V9X4R GO:0003678 11/107 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8V9X4R GO:0004386 2/107 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8QNQ9P GO:0000123 30/105 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8QNQ9P GO:0007528 1/105 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8QNQ9P GO:0035035 1/105 histone acetyltransferase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone acetyltransferase." [GOC:bf] EOG8QNQ9P GO:0005634 1/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QNQ9P GO:0005515 1/105 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QNQ9P GO:0001047 1/105 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG8QNQ9P GO:0044545 1/105 NSL complex cellular_component "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] EOG8QNQ9P GO:0016874 1/105 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8QNQ9P GO:0007526 1/105 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8QNQ9P GO:0048477 1/105 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8QNQ9P GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QNQ9P GO:0030727 1/105 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG8QNQ9P GO:0007095 1/105 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8QNQ9P GO:0030100 1/105 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8QNQ9P GO:0030718 1/105 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8QNQ9P GO:0045893 1/105 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8QNQ9P GO:0005705 1/105 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8H1DB1 GO:0005635 2/76 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG8H1DB1 GO:0005637 2/76 nuclear inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] EOG8H1DB1 GO:0016021 2/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H1DB1 GO:0046331 1/76 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8V9X4K GO:0008237 137/265 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8V9X4K GO:0008270 137/265 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8V9X4K GO:0004177 13/265 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8V9X4K GO:0006508 2/265 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8V9X4K GO:0004046 1/265 aminoacylase activity molecular_function "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] EOG8V9X4K GO:0009612 1/265 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG8V9X4K GO:0046331 1/265 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8V9X4K GO:0006909 1/265 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8V9X4K GO:0042391 1/265 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8V9X4K GO:2001020 1/265 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8V9X4K GO:0007638 1/265 mechanosensory behavior biological_process "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] EOG8BVV9G GO:0004535 1/69 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG8323D1 GO:0016021 1/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8323D1 GO:0008519 1/9 ammonium transmembrane transporter activity molecular_function "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732] EOG8323D2 GO:0006915 2/38 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8F4VX2 GO:0003677 1/20 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVN9 GO:0005634 97/397 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVN9 GO:0006351 90/397 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0007275 89/397 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8STVN9 GO:0006355 52/397 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0003677 52/397 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVN9 GO:0003700 44/397 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8STVN9 GO:0043565 43/397 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8STVN9 GO:0006366 3/397 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8STVN9 GO:0003705 3/397 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0045944 3/397 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0048813 2/397 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8STVN9 GO:0048749 2/397 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8STVN9 GO:0048854 2/397 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8STVN9 GO:0016319 2/397 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8STVN9 GO:0007526 1/397 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8STVN9 GO:0007420 1/397 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8STVN9 GO:0007628 1/397 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG8STVN9 GO:0043704 1/397 photoreceptor cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] EOG8STVN9 GO:0045676 1/397 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8STVN9 GO:0035214 1/397 eye-antennal disc development biological_process "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0007455 1/397 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0043567 1/397 regulation of insulin-like growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] EOG8STVN9 GO:0001745 1/397 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8STVN9 GO:0001158 1/397 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8STVN9 GO:0048666 1/397 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8STVN9 GO:0030182 1/397 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8STVN9 GO:0008347 1/397 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8STVN9 GO:0042676 1/397 compound eye cone cell fate commitment biological_process "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] EOG8STVN9 GO:0010628 1/397 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8STVN9 GO:0007517 1/397 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8STVN9 GO:0005515 1/397 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8STVN9 GO:0008056 1/397 ocellus development biological_process "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] EOG8STVN9 GO:0004000 1/397 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8STVN9 GO:0048036 1/397 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8STVN9 GO:0040018 1/397 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8STVN9 GO:0042673 1/397 regulation of retinal cone cell fate specification biological_process "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] EOG8STVN9 GO:0042682 1/397 regulation of compound eye cone cell fate specification biological_process "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] EOG8STVN9 GO:0045893 1/397 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0000976 1/397 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8MWBMX GO:0005622 143/592 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MWBMX GO:0005215 143/592 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8MWBMX GO:0022008 1/592 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MWBMX GO:0016787 1/592 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8J9QD0 GO:0008241 2/29 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8J9QD0 GO:0016020 2/29 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8J9QD0 GO:0008237 2/29 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG88GZJM GO:0015074 16/52 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG88GZJM GO:0003676 16/52 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZJM GO:0005634 2/52 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87DCX7 GO:0008061 105/374 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87DCX7 GO:0006030 105/374 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG87DCX7 GO:0005576 103/374 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87DCX7 GO:0005615 2/374 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG87DCX7 GO:0010716 1/374 negative regulation of extracellular matrix disassembly biological_process "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] EOG87DCX7 GO:0032504 1/374 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG87DCX7 GO:0040003 1/374 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG87DCX4 GO:0009055 2/5 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG87DCX4 GO:0016787 1/5 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8N06WK GO:0008831 4/9 dTDP-4-dehydrorhamnose reductase activity molecular_function "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799] EOG8N06WK GO:0045226 4/9 extracellular polysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] EOG8MWBMN GO:0008270 26/99 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MWBMC GO:0051539 40/124 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8MWBMC GO:0008137 28/124 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8MWBMC GO:0010181 27/124 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8MWBMC GO:0051287 25/124 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8MWBMC GO:0016651 12/124 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8MWBMC GO:0005615 1/124 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8MWBMC GO:0032504 1/124 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8KPWR7 GO:0005524 26/100 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KPWR7 GO:0004674 25/100 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8KPWR7 GO:0007165 16/100 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8KPWR7 GO:0005840 3/100 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8KPWR7 GO:0040018 1/100 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8KPWR7 GO:0007584 1/100 response to nutrient biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] EOG8KPWR7 GO:0005874 1/100 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8KPWR7 GO:0006974 1/100 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8KPWR7 GO:0045927 1/100 positive regulation of growth biological_process "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG8KPWR7 GO:0005829 1/100 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8KPWR7 GO:0051124 1/100 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8KPWR7 GO:0008361 1/100 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG8KPWR7 GO:0048786 1/100 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8KPWR7 GO:0046622 1/100 positive regulation of organ growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8KPWR7 GO:0016239 1/100 positive regulation of macroautophagy biological_process "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] EOG8KPWR7 GO:0008340 1/100 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8KPWR7 GO:0004711 1/100 ribosomal protein S6 kinase activity molecular_function "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] EOG8KPWR7 GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KPWR7 GO:0030307 1/100 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8KPWR7 GO:0030536 1/100 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8KPWR7 GO:0006468 1/100 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8KPWR7 GO:0000226 1/100 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8KPWR7 GO:0045793 1/100 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8KPWR7 GO:0007411 1/100 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8KPWR7 GO:0040007 1/100 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8KPWR7 GO:0010508 1/100 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8KPWR7 GO:0048477 1/100 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8KPWR7 GO:0007015 1/100 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8KPWR7 GO:0004697 1/100 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8KPWR7 GO:0006909 1/100 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KPWR7 GO:2001023 1/100 regulation of response to drug biological_process "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol] EOG8KPWR7 GO:0048813 1/100 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8KPWR8 GO:0051536 5/10 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8KPWR8 GO:0016491 4/10 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8KPWR8 GO:0005506 4/10 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8KPWR8 GO:0010181 4/10 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8KPWR8 GO:0003824 1/10 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN42X GO:0003824 27/204 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN42X GO:0004802 3/204 transketolase activity molecular_function "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] EOG8SN42X GO:0005875 2/204 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8SN42X GO:0031122 2/204 cytoplasmic microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] EOG8SN42X GO:0090063 1/204 positive regulation of microtubule nucleation biological_process "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] EOG8SN42X GO:0000922 1/204 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8SN42X GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SN42X GO:0005813 1/204 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8SN42X GO:0007067 1/204 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8SN42X GO:0007029 1/204 endoplasmic reticulum organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] EOG8SN42X GO:0008017 1/204 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8SN42X GO:0007143 1/204 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8SN42X GO:0048477 1/204 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8SN42X GO:0035371 1/204 microtubule plus-end cellular_component "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] EOG8SN42X GO:0045450 1/204 bicoid mRNA localization biological_process "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] EOG8SN42X GO:0031935 1/204 regulation of chromatin silencing biological_process "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] EOG8SN42X GO:0007344 1/204 pronuclear fusion biological_process "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] EOG8SN42X GO:0016325 1/204 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG8SN42X GO:0005811 1/204 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8SN42X GO:0007017 1/204 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8SN42X GO:0000022 1/204 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8SN42X GO:0007411 1/204 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SN42X GO:0015631 1/204 tubulin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] EOG8KPWRT GO:0004176 12/95 ATP-dependent peptidase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] EOG8V720R GO:0003676 5/28 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KPWRW GO:0003723 1/16 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8KPWRW GO:0015934 1/16 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG8KPWRW GO:0003735 1/16 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8KPWRW GO:0016740 1/16 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8KPWRW GO:0006412 1/16 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8ZKN1M GO:0003676 4/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZKN1M GO:0005634 3/41 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZKN1M GO:0008270 3/41 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZKN1M GO:0046872 1/41 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85QKV5 GO:0009058 1/4 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG85QKV7 GO:0030246 32/98 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG85QKV7 GO:0046872 1/98 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85QKV7 GO:0008039 1/98 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG85QKV7 GO:0016936 1/98 galactoside binding molecular_function "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732] EOG85QKV7 GO:0005829 1/98 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG85QKV0 GO:0003677 2/119 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85QKV0 GO:0007419 1/119 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG85QKV0 GO:0007426 1/119 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG85QKV0 GO:0005634 1/119 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85QKV0 GO:0007009 1/119 plasma membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG85QKV0 GO:0008362 1/119 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG85QKV0 GO:0003700 1/119 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85QKV0 GO:0042127 1/119 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG85QKV0 GO:0043565 1/119 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85QKV0 GO:0042803 1/119 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG85QKV0 GO:0007428 1/119 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG85QKV0 GO:0007464 1/119 R3/R4 cell fate commitment biological_process "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG85QKV0 GO:0007402 1/119 ganglion mother cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG85QKV0 GO:0040003 1/119 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG85QKV0 GO:0007399 1/119 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG85QKV0 GO:0003382 1/119 epithelial cell morphogenesis biological_process "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG85QKV0 GO:0006351 1/119 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG85QKV0 GO:0061024 1/119 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG85QKV0 GO:0042052 1/119 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG85QKV0 GO:0007424 1/119 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG85QKV0 GO:0061041 1/119 regulation of wound healing biological_process "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] EOG85QKV0 GO:0035159 1/119 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG85QKV0 GO:0008360 1/119 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG85QKV0 GO:0035152 1/119 regulation of tube architecture, open tracheal system biological_process "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] EOG85QKV0 GO:0045944 1/119 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG89625K GO:0016021 33/133 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89625K GO:0016758 27/133 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG89625K GO:0004100 8/133 chitin synthase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16] EOG89625K GO:0060439 1/133 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG89625K GO:0009611 1/133 response to wounding biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] EOG89625K GO:0007424 1/133 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG89625K GO:0006035 1/133 cuticle chitin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] EOG89625K GO:0006886 1/133 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG89625K GO:0035159 1/133 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG89625K GO:0007443 1/133 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG89625K GO:0007430 1/133 terminal branching, open tracheal system biological_process "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG89625K GO:0008362 1/133 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG89625K GO:0001838 1/133 embryonic epithelial tube formation biological_process "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] EOG89625K GO:0035158 1/133 regulation of tube diameter, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] EOG8MWBM1 GO:0008152 40/136 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8MWBM1 GO:0051539 34/136 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8MWBM1 GO:0003994 5/136 aconitate hydratase activity molecular_function "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] EOG8MWBM1 GO:0007370 1/136 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG8MWBM1 GO:0030350 1/136 iron-responsive element binding molecular_function "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] EOG84N18B GO:0042409 4/11 caffeoyl-CoA O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] EOG84N18B GO:0008171 2/11 O-methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] EOG87DCXJ GO:0003723 3/27 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87DCXJ GO:0003735 2/27 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG87DCXJ GO:0006412 2/27 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG87DCXJ GO:0015934 1/27 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG87DCXJ GO:0005840 1/27 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG87DCXJ GO:0008173 1/27 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG87DCXJ GO:0006396 1/27 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG89625Z GO:0003707 26/92 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG89625Z GO:0005634 26/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89625Z GO:0004887 22/92 thyroid hormone receptor activity molecular_function "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling] EOG89625Z GO:0043565 18/92 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG89625Z GO:0008270 18/92 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89625Z GO:0003677 9/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89625Z GO:0046872 7/92 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89625Z GO:0006351 4/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG89625Z GO:0003700 4/92 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG89625Z GO:0030522 1/92 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG89625Z GO:0019730 1/92 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG89625Z GO:0020037 1/92 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG89625Z GO:0007275 1/92 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG89625Z GO:0007553 1/92 regulation of ecdysteroid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] EOG89625Z GO:0018990 1/92 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG89625Z GO:0048477 1/92 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG89625Z GO:0004879 1/92 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG89625Z GO:0007591 1/92 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG89625Z GO:0010468 1/92 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG89625Z GO:0035075 1/92 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG88GZJ7 GO:0003676 1/365 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZJ7 GO:0003677 1/365 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88GZJ7 GO:0003899 1/365 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG88GZJ7 GO:0006351 1/365 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88GZJ6 GO:0005319 27/99 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG88GZJ6 GO:0003700 1/99 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88GZJ6 GO:0003677 1/99 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88GZJ6 GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88GZJ6 GO:0030513 1/99 positive regulation of BMP signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] EOG88GZJ6 GO:0005615 1/99 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG88GZJ6 GO:0043395 1/99 heparan sulfate proteoglycan binding molecular_function "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732] EOG88GZJ6 GO:0007474 1/99 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG88GZJ6 GO:0036122 1/99 BMP binding molecular_function "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034] EOG88GZJ4 GO:0008080 20/71 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG88GZJ4 GO:0016747 9/71 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG88GZJ4 GO:0007049 1/71 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG88GZJ4 GO:0016538 1/71 cyclin-dependent protein serine/threonine kinase regulator activity molecular_function "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] EOG88GZJ4 GO:0051301 1/71 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8B013N GO:0000226 20/106 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8B013N GO:0005874 20/106 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8DFS2X GO:0042765 27/94 GPI-anchor transamidase complex cellular_component "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] EOG8DFS2X GO:0016255 27/94 attachment of GPI anchor to protein biological_process "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] EOG8DFS2X GO:0046872 1/94 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PZMN9 GO:0016021 16/37 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PZMN9 GO:0004252 16/37 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8B013G GO:0003824 1/9 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8B013G GO:0009750 1/9 response to fructose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] EOG8B013G GO:0030976 1/9 thiamine pyrophosphate binding molecular_function "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg] EOG8B013G GO:0003700 1/9 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8B013G GO:0003677 1/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B013G GO:0000287 1/9 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG851H4T GO:0016021 7/26 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG851H4T GO:0016491 7/26 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8D293Q GO:0016459 26/101 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8D293Q GO:0005524 26/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D293Q GO:0003774 26/101 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8D293Q GO:0007552 1/101 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8D293Q GO:0008017 1/101 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8D293Q GO:0006997 1/101 nucleus organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] EOG8D293Q GO:0007015 1/101 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8D293Q GO:0055059 1/101 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8D293Q GO:0048477 1/101 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8D293Q GO:0070865 1/101 investment cone cellular_component "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] EOG8D293Q GO:0032027 1/101 myosin light chain binding molecular_function "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah] EOG8D293Q GO:0043234 1/101 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8D293Q GO:0005875 1/101 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8D293Q GO:0005516 1/101 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8D293Q GO:0070856 1/101 myosin VI light chain binding molecular_function "Interacting selectively and non-covalently with a light chain of a myosin VI complex." [GOC:sart] EOG8D293Q GO:0031476 1/101 myosin VI complex cellular_component "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8D293Q GO:0008363 1/101 larval chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8D293Q GO:0007286 1/101 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8D293Q GO:0032970 1/101 regulation of actin filament-based process biological_process "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] EOG8D293Q GO:0030139 1/101 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG8D293Q GO:0051647 1/101 nucleus localization biological_process "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8D293Q GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8D293Q GO:0007298 1/101 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8D293Q GO:0061024 1/101 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8D293Q GO:0006200 1/101 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8D293Q GO:0007391 1/101 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8D293Q GO:0016333 1/101 morphogenesis of follicular epithelium biological_process "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] EOG8D293Q GO:0045175 1/101 basal protein localization biological_process "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] EOG8D293Q GO:0007560 1/101 imaginal disc morphogenesis biological_process "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] EOG8D293Q GO:0007297 1/101 ovarian follicle cell migration biological_process "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8D293Q GO:0000146 1/101 microfilament motor activity molecular_function "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8D293Q GO:0045178 1/101 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8D293Q GO:0040001 1/101 establishment of mitotic spindle localization biological_process "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] EOG8D293Q GO:0055057 1/101 neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] EOG8D293Q GO:0016461 1/101 unconventional myosin complex cellular_component "A portmanteau term for myosins other than myosin II." [GOC:ma] EOG8D293Q GO:0005938 1/101 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8D293Q GO:0051015 1/101 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG8D293Q GO:0042623 1/101 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8D293Q GO:0045217 1/101 cell-cell junction maintenance biological_process "The maintenance of junctions between cells." [GOC:ai] EOG8D293Q GO:0047497 1/101 mitochondrion transport along microtubule biological_process "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] EOG8D293Q GO:0045172 1/101 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8D293Q GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D293Q GO:0019749 1/101 cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] EOG8D293Q GO:0070864 1/101 sperm individualization complex cellular_component "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716] EOG8D293Q GO:0007051 1/101 spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] EOG8D293Q GO:0030317 1/101 sperm motility biological_process "Any process involved in the controlled movement of a sperm cell." [GOC:jl] EOG8D293Q GO:0032880 1/101 regulation of protein localization biological_process "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] EOG8D293Q GO:0007291 1/101 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8D293Q GO:0032956 1/101 regulation of actin cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] EOG8D293Q GO:0030048 1/101 actin filament-based movement biological_process "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] EOG8D293Q GO:0045167 1/101 asymmetric protein localization involved in cell fate determination biological_process "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] EOG8D293Q GO:0008104 1/101 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8D293Q GO:0045921 1/101 positive regulation of exocytosis biological_process "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] EOG8D293Q GO:0008152 1/101 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8D293Q GO:0030036 1/101 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8D293Q GO:0007283 1/101 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8D293Q GO:0030589 1/101 pseudocleavage involved in syncytial blastoderm formation biological_process "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8D293Q GO:0003779 1/101 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8CZDZH GO:0016805 1/3 dipeptidase activity molecular_function "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] EOG8CZDZH GO:0008237 1/3 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8CZDZH GO:0031225 1/3 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8CZDZH GO:0046872 1/3 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TF318 GO:0005524 17/45 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF318 GO:0004674 17/45 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8TF318 GO:0006468 1/45 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8TF318 GO:0007155 1/45 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8TF318 GO:0042981 1/45 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8TF318 GO:0004683 1/45 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8TF318 GO:0007476 1/45 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8TF318 GO:0007480 1/45 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8TF318 GO:0002009 1/45 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8TF318 GO:0008360 1/45 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8TF319 GO:0003824 4/14 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8TF310 GO:0003676 27/104 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TF310 GO:0005634 3/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TF310 GO:0008270 3/104 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TF310 GO:0003677 1/104 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TF314 GO:0003964 1/6 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8TF314 GO:0008270 1/6 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TF314 GO:0003723 1/6 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8TF314 GO:0006351 1/6 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8TF314 GO:0003677 1/6 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TF314 GO:0003899 1/6 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8TF315 GO:0016491 1/10 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8G7FG1 GO:0008413 1/5 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity molecular_function "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881] EOG8G7FG1 GO:0006281 1/5 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8R7XR6 GO:0004871 26/101 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8R7XR6 GO:0005525 26/101 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8R7XR6 GO:0003924 26/101 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8R7XR6 GO:0007186 25/101 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8R7XR6 GO:0046872 3/101 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8R7XR6 GO:0005834 2/101 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG8R7XR6 GO:0007191 2/101 adenylate cyclase-activating dopamine receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling] EOG8R7XR6 GO:0007476 2/101 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8R7XR6 GO:0031234 2/101 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG8R7XR6 GO:0001664 2/101 G-protein coupled receptor binding molecular_function "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] EOG8R7XR6 GO:0031683 2/101 G-protein beta/gamma-subunit complex binding molecular_function "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] EOG8R7XR6 GO:0007268 2/101 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8R7XR6 GO:0005886 2/101 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8R7XR6 GO:0007528 2/101 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8R7XR6 GO:0035220 1/101 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8R7XR6 GO:0007608 1/101 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8R7XR6 GO:0007606 1/101 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8R7XR6 GO:0007611 1/101 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8R7XR6 GO:0050916 1/101 sensory perception of sweet taste biological_process "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8R7XR6 GO:0010353 1/101 response to trehalose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] EOG8R7XR6 GO:0005604 1/101 basement membrane cellular_component "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] EOG8R7XR6 GO:0002165 1/101 instar larval or pupal development biological_process "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8R7XR6 GO:0022416 1/101 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8R7XR6 GO:0048148 1/101 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG8R7XR6 GO:0007632 1/101 visual behavior biological_process "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] EOG8R7XR6 GO:2000253 1/101 positive regulation of feeding behavior biological_process "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] EOG85F03P GO:0010508 22/94 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG85F03P GO:0006914 2/94 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG85F03P GO:0048260 1/94 positive regulation of receptor-mediated endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] EOG85F03P GO:0008285 1/94 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG85F03P GO:0040008 1/94 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG85F03P GO:0048803 1/94 imaginal disc-derived male genitalia morphogenesis biological_process "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] EOG85F03P GO:0045746 1/94 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG85F03P GO:0007219 1/94 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8FFGJP GO:0006355 3/12 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8FFGJP GO:0003677 3/12 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QRKN0 GO:0017183 1/64 peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] EOG8QRKN0 GO:0046872 1/64 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8PCD5Z GO:0004222 33/137 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8PCD5Z GO:0008270 30/137 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PCD5Z GO:0042802 1/137 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8PCD5Z GO:0051259 1/137 protein oligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8PCD5Z GO:0006509 1/137 membrane protein ectodomain proteolysis biological_process "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] EOG8TF31C GO:0055085 7/23 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8TF31C GO:0016021 7/23 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TF31C GO:0005215 5/23 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8TF31C GO:0005886 4/23 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88KTVH GO:0007218 37/97 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG88KTVH GO:0018990 37/97 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG88KTVH GO:0005576 2/97 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88KTVH GO:0007562 1/97 eclosion biological_process "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] EOG88KTVH GO:0008031 1/97 eclosion hormone activity molecular_function "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732] EOG88KTVH GO:0005184 1/97 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG88KTVH GO:0007563 1/97 regulation of eclosion biological_process "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] EOG80ZTBF GO:0008270 19/87 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80ZTBF GO:0016874 3/87 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG80ZTBD GO:0005089 25/110 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG80ZTBD GO:0035556 12/110 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG80ZTBD GO:0004725 2/110 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG80ZTBD GO:0016740 2/110 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG80ZTBD GO:0030426 1/110 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG80ZTBD GO:0007480 1/110 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG80ZTBD GO:0046331 1/110 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG80ZTBD GO:0031234 1/110 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG80ZTBD GO:0030036 1/110 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG80ZTBD GO:0050770 1/110 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG80ZTBD GO:0007417 1/110 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG80ZTBD GO:0031532 1/110 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG80ZTBD GO:0035025 1/110 positive regulation of Rho protein signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] EOG80ZTBD GO:0007411 1/110 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG80ZTBD GO:0032319 1/110 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG80ZTBD GO:0030424 1/110 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG80ZTBD GO:0007422 1/110 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG80ZTBD GO:0071772 1/110 response to BMP biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] EOG80ZTBD GO:0045887 1/110 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG80ZTBD GO:0007412 1/110 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG80ZTBD GO:0048675 1/110 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG80ZTBD GO:0016319 1/110 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8PZMNZ GO:0030246 21/30 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG80ZTBQ GO:0004827 25/95 proline-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] EOG80ZTBQ GO:0005524 25/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80ZTBQ GO:0006433 25/95 prolyl-tRNA aminoacylation biological_process "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] EOG80ZTBQ GO:0005737 25/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80ZTBQ GO:0004820 1/95 glycine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] EOG80ZTBZ GO:0022857 17/42 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG80ZTBZ GO:0016021 17/42 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8909SF GO:0003700 2/13 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8909SF GO:0005634 2/13 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XWJDM GO:0003735 25/83 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8XWJDM GO:0006412 25/83 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8XWJDM GO:0019843 25/83 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8XWJDM GO:0005840 24/83 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8XWJDM GO:0005763 1/83 mitochondrial small ribosomal subunit cellular_component "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] EOG8284GK GO:0016757 5/23 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8284GK GO:0050510 1/23 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity molecular_function "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] EOG8284GV GO:0034512 1/85 box C/D snoRNA binding molecular_function "Interacting selectively and non-covalently with box C/D small nucleolar RNA." [GOC:mah] EOG8284GV GO:0004402 1/85 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8284GV GO:0015030 1/85 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG8284GV GO:0030576 1/85 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG8SR09M GO:0046872 25/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SR09M GO:0004222 25/95 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8SR09M GO:0022857 1/95 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8SR09M GO:0016021 1/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85XB8W GO:0007018 83/336 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG85XB8W GO:0003777 82/336 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG85XB8W GO:0030286 71/336 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG85XB8W GO:0005524 54/336 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85XB8W GO:0006072 10/336 glycerol-3-phosphate metabolic process biological_process "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] EOG85XB8W GO:0009331 10/336 glycerol-3-phosphate dehydrogenase complex cellular_component "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] EOG85XB8W GO:0016887 9/336 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG85XB8W GO:0004368 9/336 glycerol-3-phosphate dehydrogenase activity molecular_function "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3] EOG85XB8W GO:0042623 3/336 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG85XB8W GO:0006200 3/336 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG85XB8W GO:0005875 2/336 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG85XB8W GO:0006302 1/336 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG85XB8W GO:2001019 1/336 positive regulation of retrograde axon cargo transport biological_process "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] EOG85XB8W GO:0005634 1/336 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85XB8W GO:0005509 1/336 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG85XB8W GO:0004527 1/336 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG85XB8W GO:0007605 1/336 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG85XB8W GO:0004519 1/336 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG85XB8W GO:0052591 1/336 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity molecular_function "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN] EOG85XB8W GO:0007126 1/336 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG85XB8W GO:0030145 1/336 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG83N9SV GO:0016021 1/69 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83N9SV GO:0004930 1/69 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8Z919V GO:0008241 93/395 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8Z919V GO:0016020 92/395 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z919V GO:0008237 91/395 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8Z919V GO:0004180 14/395 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8Z919V GO:0005615 2/395 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z919V GO:0016491 2/395 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8Z919V GO:0006508 2/395 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8Z919V GO:0045938 1/395 positive regulation of circadian sleep/wake cycle, sleep biological_process "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] EOG8Z919V GO:0007289 1/395 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG8Z919V GO:0009609 1/395 response to symbiotic bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732] EOG8Z919V GO:0005576 1/395 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z919V GO:0046872 1/395 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Z919V GO:0004222 1/395 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8Z919V GO:0007291 1/395 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8Z919V GO:0007507 1/395 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8Z919V GO:0003700 1/395 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z919V GO:0016021 1/395 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z919V GO:0005634 1/395 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z919V GO:0005515 1/395 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8Z919V GO:0030431 1/395 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8Z919V GO:0007552 1/395 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8Z919V GO:0008270 1/395 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z919V GO:0043565 1/395 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG869TBS GO:0006412 1/7 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG869TBS GO:0003735 1/7 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG869TBS GO:0005840 1/7 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8R7XQJ GO:0005089 25/96 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8R7XQJ GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8R7XQJ GO:0035025 1/96 positive regulation of Rho protein signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] EOG8R7XQJ GO:0007411 1/96 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8R7XQJ GO:0032319 1/96 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8R7XQJ GO:0045179 1/96 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8R7XQJ GO:0016020 1/96 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8R7XQJ GO:0035277 1/96 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8R7XQJ GO:0007480 1/96 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8R7XQJ GO:0008270 1/96 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R7XQJ GO:0002121 1/96 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8R7XQJ GO:0003676 1/96 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F7R22 GO:0090175 1/84 regulation of establishment of planar polarity biological_process "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG86HJS9 GO:0042302 6/17 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8F7R26 GO:0007156 4/27 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8F7R26 GO:0005509 4/27 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8F7R26 GO:0016021 3/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F7R26 GO:0005886 2/27 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG847J7T GO:0046872 2/34 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83N9SJ GO:0008233 133/167 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG847J7W GO:0046872 5/16 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG847J7W GO:0005634 4/16 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG847J7W GO:0003676 4/16 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG847J7W GO:0003677 1/16 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8R7XQG GO:0004842 22/126 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8R7XQG GO:0008270 22/126 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R7XQG GO:0007601 2/126 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8R7XQG GO:0050896 2/126 response to stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] EOG8R7XQG GO:0005516 2/126 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8R7XQG GO:0005319 2/126 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG8R7XQG GO:0007291 2/126 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8R7XQG GO:0007286 2/126 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8R7XQG GO:0007399 1/126 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8R7XQG GO:0042066 1/126 perineurial glial growth biological_process "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560] EOG8R7XQG GO:0042065 1/126 glial cell growth biological_process "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] EOG8VQD57 GO:0005789 26/85 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8VQD57 GO:0016021 26/85 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VQD57 GO:0016758 26/85 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8VQD57 GO:0006506 26/85 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG8616N8 GO:0003676 7/1106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616N8 GO:0003677 3/1106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8616N8 GO:0008270 3/1106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8616N8 GO:0003964 2/1106 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8616N8 GO:0015074 2/1106 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8616N8 GO:0003723 2/1106 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8616N8 GO:0004190 1/1106 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8616N8 GO:0008237 1/1106 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8FR37N GO:0005615 1/56 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8FR37N GO:0007166 1/56 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8FR37N GO:0048018 1/56 receptor agonist activity molecular_function "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732] EOG8FR37N GO:2000252 1/56 negative regulation of feeding behavior biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] EOG8FR37N GO:0005576 1/56 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG847J78 GO:0005975 23/58 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG847J78 GO:0004553 21/58 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG847J78 GO:0003700 1/58 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG847J78 GO:0004563 1/58 beta-N-acetylhexosaminidase activity molecular_function "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] EOG847J78 GO:0043565 1/58 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8K0T47 GO:0008270 5/119 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K0T47 GO:0003676 5/119 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K0T47 GO:0004190 2/119 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG88WFHS GO:0008168 1/23 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG86HJSQ GO:0016491 24/98 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG86HJSQ GO:0004316 1/98 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG86HJSQ GO:0016630 1/98 protochlorophyllide reductase activity molecular_function "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] EOG86HJSQ GO:0004090 1/98 carbonyl reductase (NADPH) activity molecular_function "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] EOG89KJ4W GO:0004984 22/104 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG89KJ4W GO:0005549 22/104 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG89KJ4W GO:0004930 21/104 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG89KJ4W GO:0016021 21/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89KJ4W GO:0005886 16/104 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89KJ4W GO:0004812 6/104 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG89KJ4W GO:0006418 6/104 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG89KJ4W GO:0005524 6/104 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89KJ4W GO:0003676 5/104 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89KJ4W GO:0050911 2/104 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG89KJ4W GO:0030425 1/104 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG89KJ4W GO:0048149 1/104 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG89KJ4W GO:0007608 1/104 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG89KJ4W GO:0019236 1/104 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG89KJ4W GO:0042755 1/104 eating behavior biological_process "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, ISBN:01928006X] EOG89KJ4W GO:0051291 1/104 protein heterooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG89KJ4W GO:0042803 1/104 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG89KJ4W GO:0016020 1/104 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG89KJ4W GO:0042048 1/104 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG89KJ4S GO:0045466 1/215 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG89KJ4S GO:0007465 1/215 R7 cell fate commitment biological_process "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG89KJ4S GO:0019897 1/215 extrinsic component of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] EOG89KJ4S GO:0007611 1/215 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG89KJ4S GO:0048149 1/215 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG89KJ4S GO:0042332 1/215 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG89KJ4S GO:0007616 1/215 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG89KJ4S GO:0008355 1/215 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG89KJ4S GO:0007156 1/215 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG89KJ4Z GO:0005874 72/234 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG89KJ4Z GO:0005525 72/234 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG89KJ4Z GO:0005200 71/234 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG89KJ4Z GO:0003924 70/234 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG89KJ4Z GO:0007017 70/234 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG89KJ4Z GO:0051258 70/234 protein polymerization biological_process "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] EOG89KJ4Z GO:0005737 64/234 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89KJ4Z GO:0051298 2/234 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG89KJ4Z GO:0007435 1/234 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG89KJ4Z GO:0016203 1/234 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8284G1 GO:0005524 43/145 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8284G1 GO:0045261 41/145 proton-transporting ATP synthase complex, catalytic core F(1) cellular_component "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] EOG8284G1 GO:0046933 40/145 proton-transporting ATP synthase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] EOG8284G1 GO:0015986 40/145 ATP synthesis coupled proton transport biological_process "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] EOG8284G1 GO:0015991 39/145 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8284G1 GO:0015992 3/145 proton transport biological_process "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG8284G1 GO:0005811 2/145 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8284G1 GO:0005743 2/145 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8284G1 GO:0046034 2/145 ATP metabolic process biological_process "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] EOG8284G1 GO:0048515 1/145 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8284G1 GO:0016787 1/145 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8284G1 GO:0010155 1/145 regulation of proton transport biological_process "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] EOG8284G1 GO:0046331 1/145 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8284G1 GO:0005739 1/145 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8284G1 GO:0008340 1/145 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8284G1 GO:0006754 1/145 ATP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] EOG8VMHV6 GO:0005524 2/148 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VMHV6 GO:0003677 2/148 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VMHV6 GO:0050254 1/148 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8VMHV6 GO:0005887 1/148 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VMHV6 GO:0016480 1/148 negative regulation of transcription from RNA polymerase III promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] EOG8VMHV6 GO:0004386 1/148 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VMHV6 GO:0016162 1/148 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG8HX7F3 GO:0005525 23/95 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8HX7F3 GO:0005622 23/95 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8HX7F3 GO:0007264 23/95 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8HX7F3 GO:0035011 1/95 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG841ST4 GO:0005840 1/4 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG841ST4 GO:0003735 1/4 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG841ST4 GO:0000166 1/4 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG841ST4 GO:0006412 1/4 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8M946P GO:0006457 18/69 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8M946P GO:0051259 18/69 protein oligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8M946P GO:0006950 1/69 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8M946P GO:0005739 1/69 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8HX7GX GO:0032065 1/4 cortical protein anchoring biological_process "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] EOG8HX7GX GO:0035556 1/4 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8HX7GX GO:0005543 1/4 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8HX7GX GO:0005938 1/4 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG83V290 GO:0004478 2/15 methionine adenosyltransferase activity molecular_function "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] EOG83V290 GO:0006556 2/15 S-adenosylmethionine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] EOG83V290 GO:0005524 2/15 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83V290 GO:0006730 1/15 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG83V290 GO:0046872 1/15 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8F4VVJ GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F4VVJ GO:0042626 1/8 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8F4VVJ GO:0005524 1/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WDGRV GO:0008649 26/174 rRNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] EOG8WDGRV GO:0005525 25/174 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8WDGRV GO:0005634 25/174 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGRV GO:0003924 25/174 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8WDGRV GO:0003746 4/174 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8WDGRV GO:0020037 2/174 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8WDGRV GO:0016705 2/174 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8WDGRV GO:0005506 2/174 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8WDGRV GO:0004568 1/174 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8WDGRV GO:0005975 1/174 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WDGRV GO:0004497 1/174 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8WDGRV GO:0006032 1/174 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WDGRX GO:0004871 20/95 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8WDGRX GO:0006355 15/95 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8WDGRX GO:0005634 10/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGRX GO:0048471 9/95 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8WDGRX GO:0048511 8/95 rhythmic process biological_process "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] EOG8WDGRX GO:0005737 2/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WDGRX GO:0060086 1/95 circadian temperature homeostasis biological_process "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb] EOG8WDGRX GO:0001306 1/95 age-dependent response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] EOG8WDGRX GO:0007619 1/95 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8WDGRX GO:0007617 1/95 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8WDGRX GO:0042752 1/95 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG8WDGRX GO:0003712 1/95 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8WDGRX GO:0003989 1/95 acetyl-CoA carboxylase activity molecular_function "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] EOG8WDGRX GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WDGRX GO:0048148 1/95 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG8WDGRX GO:0000122 1/95 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8WDGRX GO:0045187 1/95 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG8WDGRX GO:0008340 1/95 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8WDGRX GO:2000678 1/95 negative regulation of transcription regulatory region DNA binding biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] EOG8WDGRX GO:0003700 1/95 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8WDGRX GO:0009649 1/95 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG8WDGRX GO:0046982 1/95 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8WDGRX GO:0009266 1/95 response to temperature stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] EOG8WDGRX GO:0007622 1/95 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG8WDGRX GO:0048512 1/95 circadian behavior biological_process "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] EOG8WDGRX GO:0043153 1/95 entrainment of circadian clock by photoperiod biological_process "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] EOG8WDGRX GO:0007623 1/95 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8WDGRX GO:0007620 1/95 copulation biological_process "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] EOG8WDGRX GO:0003714 1/95 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8WDGRX GO:0009416 1/95 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8WDGRX GO:0045892 1/95 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8WDGRX GO:0008134 1/95 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8WDGRX GO:0045433 1/95 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG8WDGRX GO:0005667 1/95 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8WDGRX GO:0007616 1/95 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8WDGRX GO:0045475 1/95 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8WDGRX GO:0006979 1/95 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8WDGRX GO:0042803 1/95 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8WDGRX GO:0042745 1/95 circadian sleep/wake cycle biological_process "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] EOG8WDGRX GO:0008062 1/95 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG8S1WNM GO:0006464 23/93 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8S1WNM GO:0003824 21/93 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S1WNM GO:0016740 2/93 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8S1WNM GO:0009249 1/93 protein lipoylation biological_process "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] EOG8S1WNM GO:0016874 1/93 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8DZ4CF GO:0003700 2/11 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DZ4CF GO:0043565 2/11 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8DZ4CF GO:0005634 1/11 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG898XF8 GO:0016020 25/94 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG898XF8 GO:0016887 24/94 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG898XF8 GO:0005524 24/94 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MWBNZ GO:0005801 23/82 cis-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] EOG8MWBNZ GO:0006888 23/82 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG8MWBNZ GO:0006965 1/82 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] EOG8MWBNZ GO:0045087 1/82 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8MWBNZ GO:0030008 1/82 TRAPP complex cellular_component "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257] EOG8MWBNZ GO:0016192 1/82 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8MWBNZ GO:0006962 1/82 male-specific antibacterial humoral response biological_process "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] EOG8MWBNZ GO:0005576 1/82 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V9X5V GO:0005524 22/80 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V9X5V GO:0004674 20/80 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8V9X5V GO:0004672 2/80 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8V9X5V GO:0004683 1/80 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8V9X5V GO:0006468 1/80 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8V9X5V GO:0048812 1/80 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG898XF6 GO:0016905 1/154 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG8V9X5N GO:0005634 5/24 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Z0DMZ GO:0015074 3/19 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8Z0DMZ GO:0004190 2/19 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8Z0DMZ GO:0003964 2/19 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8Z0DMZ GO:0003723 2/19 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Z0DMZ GO:0003676 2/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BK7J2 GO:0008270 21/72 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BK7J2 GO:0003676 17/72 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BK7J2 GO:0003677 4/72 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BK7J2 GO:0006811 1/72 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8BK7J2 GO:0072499 1/72 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG8BK7J2 GO:0007304 1/72 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8BK7J2 GO:0007307 1/72 eggshell chorion gene amplification biological_process "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] EOG8BK7J2 GO:0007306 1/72 eggshell chorion assembly biological_process "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8BK7J2 GO:0016021 1/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BK7J2 GO:0006260 1/72 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8BK7J2 GO:0046716 1/72 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG83R628 GO:0003676 26/225 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83R628 GO:0005634 1/225 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83R628 GO:0046872 1/225 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M0HGN GO:0016020 30/128 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M0HGN GO:0016021 7/128 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M0HGN GO:0005634 1/128 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M0HGN GO:0006289 1/128 nucleotide-excision repair biological_process "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] EOG8M0HGN GO:0003684 1/128 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8M0HGN GO:0008654 1/128 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8M0HGN GO:0051260 1/128 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8M0HGN GO:0008270 1/128 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M0HGN GO:0003841 1/128 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] EOG8V9X59 GO:0045226 1/13 extracellular polysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] EOG8V9X59 GO:0050662 1/13 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8V9X59 GO:0008879 1/13 glucose-1-phosphate thymidylyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15228] EOG8V9X59 GO:0008460 1/13 dTDP-glucose 4,6-dehydratase activity molecular_function "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224] EOG8V9X59 GO:0009225 1/13 nucleotide-sugar metabolic process biological_process "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] EOG873S6G GO:0016591 13/62 DNA-directed RNA polymerase II, holoenzyme cellular_component "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii] EOG8M0HGC GO:0016021 35/133 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M0HGC GO:0005000 29/133 vasopressin receptor activity molecular_function "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] EOG8M0HGC GO:0004930 6/133 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8M0HGC GO:0018990 1/133 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8M0HGC GO:0007186 1/133 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8M0HGC GO:0008188 1/133 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8M0HGC GO:0007218 1/133 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8M0HGC GO:0005887 1/133 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG873S6M GO:0005524 25/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG873S6M GO:0004674 21/92 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG873S6M GO:0004672 2/92 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG873S6M GO:0008353 2/92 RNA polymerase II carboxy-terminal domain kinase activity molecular_function "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] EOG873S6M GO:0008283 1/92 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG873S6M GO:0007424 1/92 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG873S6M GO:0016049 1/92 cell growth biological_process "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] EOG873S6M GO:0051301 1/92 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG873S6M GO:0001558 1/92 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG873S6M GO:0030332 1/92 cyclin binding molecular_function "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] EOG873S6M GO:0007350 1/92 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG873S6M GO:0006468 1/92 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG873S6M GO:0004693 1/92 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG873S6M GO:0007005 1/92 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG873S6M GO:0000278 1/92 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG873S6M GO:0007259 1/92 JAK-STAT cascade biological_process "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] EOG873S6M GO:0051726 1/92 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8V9X52 GO:0046872 25/44 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8V9X52 GO:0003676 17/44 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V9X52 GO:0005634 3/44 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V9X52 GO:0001964 1/44 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8V9X52 GO:0008406 1/44 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8V9X52 GO:0045476 1/44 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8V9X52 GO:0045467 1/44 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8V9X52 GO:0045893 1/44 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8V9X52 GO:0006351 1/44 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8V9X52 GO:0007411 1/44 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8V9X52 GO:0003677 1/44 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V9X52 GO:0022008 1/44 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8V9X52 GO:0019730 1/44 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8V9X52 GO:0016199 1/44 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8V9X52 GO:0007409 1/44 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8V9X52 GO:0044719 1/44 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG8V9X52 GO:0003700 1/44 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8V9X52 GO:0005515 1/44 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8V9X52 GO:0048813 1/44 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8V9X52 GO:0002121 1/44 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8V9X52 GO:0007464 1/44 R3/R4 cell fate commitment biological_process "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG8V9X52 GO:0006355 1/44 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8V9X52 GO:0048854 1/44 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8V9X52 GO:0031987 1/44 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG880MD2 GO:0003677 1/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG880MD2 GO:0008113 1/5 peptide-methionine (S)-S-oxide reductase activity molecular_function "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] EOG880MD2 GO:0008080 1/5 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG880MD2 GO:0006355 1/5 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG880MD2 GO:0000156 1/5 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8FR37V GO:0006384 1/45 transcription initiation from RNA polymerase III promoter biological_process "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8FR37V GO:0003899 1/45 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8FR37V GO:0022008 1/45 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8FR37V GO:0005666 1/45 DNA-directed RNA polymerase III complex cellular_component "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8TTJXV GO:0006886 21/93 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8TTJXV GO:0005634 20/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTJXV GO:0030621 1/93 U4 snRNA binding molecular_function "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] EOG8TTJXV GO:0015030 1/93 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG8TTJXV GO:0030620 1/93 U2 snRNA binding molecular_function "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] EOG8TTJXV GO:0045465 1/93 R8 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] EOG8TTJXV GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TTJXV GO:0042675 1/93 compound eye cone cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] EOG8TTJXV GO:0016318 1/93 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8TTJXV GO:0007474 1/93 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8TTJXV GO:0035311 1/93 wing cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] EOG8TTJXV GO:0048749 1/93 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8TTJXV GO:0005938 1/93 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8TTJXV GO:0048471 1/93 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8TTJXV GO:0006608 1/93 snRNP protein import into nucleus biological_process "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] EOG8TTJXV GO:0006606 1/93 protein import into nucleus biological_process "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] EOG8TTJXV GO:0005737 1/93 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TTJXV GO:0008586 1/93 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8TTJXV GO:0042052 1/93 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8TTJXV GO:0007173 1/93 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8TTJXV GO:0030619 1/93 U1 snRNA binding molecular_function "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] EOG8TTJXV GO:0008283 1/93 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8TTJXV GO:0000189 1/93 MAPK import into nucleus biological_process "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] EOG8TTJXV GO:0016203 1/93 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8TTJXV GO:0043524 1/93 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8TTJXV GO:0007169 1/93 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8TTJXV GO:0030576 1/93 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG8TTJXV GO:0007476 1/93 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8TTJXV GO:0046331 1/93 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8Q2GVK GO:0003824 25/92 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8TTJXP GO:0004842 8/68 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8TTJXP GO:0008270 1/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG841STZ GO:0004843 1/73 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG841STZ GO:0003964 1/73 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG841STZ GO:0006511 1/73 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8M9468 GO:0008270 22/83 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M9468 GO:0005622 19/83 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG85XB97 GO:0030170 32/102 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG85XB97 GO:0009058 31/102 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG85XB97 GO:0016740 27/102 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG85XB97 GO:0004758 3/102 serine C-palmitoyltransferase activity molecular_function "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14764] EOG85XB97 GO:0003824 2/102 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG85XB97 GO:0005886 1/102 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85XB97 GO:0030148 1/102 sphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG85XB97 GO:0007444 1/102 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG88WFHZ GO:0000166 26/91 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG88WFHZ GO:0003676 25/91 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88WFHZ GO:2001020 1/91 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG88WFHZ GO:0003729 1/91 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG83V29H GO:0006351 1/5 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG83V29H GO:0003899 1/5 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG83V29H GO:0003677 1/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TQPRK GO:0043565 25/111 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8TQPRK GO:0003700 25/111 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8TQPRK GO:0005634 24/111 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HDW80 GO:0005634 9/49 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HDW80 GO:0003676 8/49 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HDW80 GO:0004535 1/49 poly(A)-specific ribonuclease activity molecular_function "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] EOG8Q87D3 GO:0016021 2/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Q87D3 GO:0042925 2/36 benzoate transporter activity molecular_function "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells." [GOC:jl, ISBN:0721662544] EOG8X3KHH GO:0004045 7/15 aminoacyl-tRNA hydrolase activity molecular_function "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] EOG82Z749 GO:0000166 4/62 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG82Z749 GO:0003676 4/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82Z749 GO:0016779 1/62 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG82Z749 GO:0046872 1/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82Z749 GO:0008270 1/62 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GMXBQ GO:0019706 25/98 protein-cysteine S-palmitoyltransferase activity molecular_function "Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr] EOG8GMXBQ GO:0016021 25/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GMXBQ GO:0008270 25/98 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GMXBQ GO:0018345 1/98 protein palmitoylation biological_process "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] EOG8GMXBQ GO:0016491 1/98 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GMXBQ GO:0005794 1/98 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8G1PXK GO:0016334 1/92 establishment or maintenance of polarity of follicular epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] EOG8G1PXK GO:0008285 1/92 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8G1PXK GO:0016336 1/92 establishment or maintenance of polarity of larval imaginal disc epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] EOG8SBHC1 GO:0005524 29/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SBHC1 GO:0004814 29/90 arginine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] EOG8SBHC1 GO:0006420 29/90 arginyl-tRNA aminoacylation biological_process "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8SBHC1 GO:0005737 26/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BZQGB GO:0008144 23/99 drug binding molecular_function "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] EOG8BZQGB GO:0005524 23/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BZQGB GO:0016301 22/99 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8BZQGB GO:0016773 22/99 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8BZQGB GO:0004672 1/99 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8BZQGB GO:0008406 1/99 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8BZQGB GO:0090070 1/99 positive regulation of ribosome biogenesis biological_process "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] EOG8BZQGB GO:0030117 1/99 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG8BZQGB GO:0007049 1/99 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8BZQGB GO:0007411 1/99 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8BZQGB GO:0001558 1/99 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8BZQGB GO:2000377 1/99 regulation of reactive oxygen species metabolic process biological_process "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] EOG8BZQGB GO:0006886 1/99 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8BZQGB GO:0045793 1/99 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8BZQGB GO:2001023 1/99 regulation of response to drug biological_process "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol] EOG8BZQGB GO:0042331 1/99 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8BZQGB GO:0048813 1/99 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8BZQGB GO:0009594 1/99 detection of nutrient biological_process "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8BZQGB GO:0040007 1/99 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8BZQGB GO:0051124 1/99 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8BZQGB GO:0016192 1/99 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8BZQGB GO:0007584 1/99 response to nutrient biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] EOG8BZQGB GO:0040018 1/99 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8BZQGB GO:0006974 1/99 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8BZQGB GO:0008340 1/99 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8BZQGB GO:0035264 1/99 multicellular organism growth biological_process "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] EOG8BZQGB GO:0006468 1/99 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8BZQGB GO:0032456 1/99 endocytic recycling biological_process "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] EOG8BZQGB GO:0016242 1/99 negative regulation of macroautophagy biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] EOG8BZQGB GO:0030307 1/99 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8BZQGB GO:0046622 1/99 positive regulation of organ growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8BZQGB GO:0016310 1/99 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8BZQGB GO:0043621 1/99 protein self-association molecular_function "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] EOG8BZQGB GO:0001934 1/99 positive regulation of protein phosphorylation biological_process "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] EOG8CC6F9 GO:0043565 1/47 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CC6F9 GO:0003700 1/47 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X3KHR GO:0030414 19/74 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8X3KHR GO:0005576 19/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CC6F7 GO:0055085 36/143 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8CC6F7 GO:0016021 36/143 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1HB GO:0004867 1/5 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8909PX GO:0004198 4/32 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8909PX GO:0005622 4/32 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8HMMQ4 GO:0007156 6/39 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8HMMQ4 GO:0016021 6/39 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HMMQ4 GO:0005886 6/39 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HMMQ4 GO:0005509 6/39 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8CC6FM GO:0030170 27/99 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8CC6FM GO:0031071 22/99 cysteine desulfurase activity molecular_function "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] EOG8CC6FM GO:0006534 21/99 cysteine metabolic process biological_process "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] EOG8CC6FM GO:0003824 5/99 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8CC6FM GO:0008483 2/99 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8CC6FM GO:0005634 1/99 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6FM GO:0005875 1/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8CC6FM GO:0005739 1/99 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8GMXB7 GO:0005524 24/85 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GMXB7 GO:0008026 24/85 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8GMXB7 GO:0003723 21/85 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GMXB7 GO:0003676 3/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GMXB7 GO:0008152 1/85 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8GMXB7 GO:0004386 1/85 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8GMXB0 GO:0008233 12/66 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8CRPFD GO:0003723 1/83 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CRPFD GO:0003964 1/83 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BGCC6 GO:0003824 7/17 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8BGCC6 GO:0006284 6/17 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8BGCC6 GO:0006281 1/17 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8BGCC6 GO:0005634 1/17 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BGCC6 GO:0003677 1/17 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TF300 GO:0022008 1/123 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8HMMQG GO:0046872 2/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CRPFQ GO:0016021 23/139 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPFQ GO:0008080 21/139 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG82Z74H GO:0005874 33/97 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG82Z74H GO:0000226 33/97 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8RZ1F9 GO:0022008 1/86 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8X3KH2 GO:0017111 1/8 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8X3KH2 GO:0009143 1/8 nucleoside triphosphate catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG8HMMQP GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HMMQP GO:0019538 1/5 protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma] EOG8HMMQP GO:0017111 1/5 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8HMMQT GO:0009152 31/94 purine ribonucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8HMMQT GO:0004018 31/94 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] EOG8HMMQT GO:0070626 3/94 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity molecular_function "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde] EOG8HMMQT GO:0003676 1/94 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HMMQT GO:0004190 1/94 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8HMMQT GO:0008270 1/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZCWJH GO:0006030 12/33 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8ZCWJH GO:0005576 12/33 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8ZCWJH GO:0008061 12/33 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8ZCWJH GO:0042600 1/33 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8ZCWJH GO:0031012 1/33 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8ZCWJH GO:0005201 1/33 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8G4K5H GO:0006777 27/97 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG8G4K5H GO:0005829 24/97 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8G4K5H GO:0030366 24/97 molybdopterin synthase activity molecular_function "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] EOG8G4K5H GO:0019008 24/97 molybdopterin synthase complex cellular_component "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] EOG8HDW8D GO:0030983 1/10 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8HDW8D GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HDW8D GO:0043565 1/10 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8HDW8D GO:0006298 1/10 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8RNDS6 GO:0004129 4/72 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8RNDS6 GO:0005739 3/72 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8RNDS4 GO:0005634 23/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RNDS4 GO:0003700 22/92 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RNDS4 GO:0000976 16/92 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8RNDS4 GO:0043565 7/92 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RNDS4 GO:0007417 1/92 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8RNDS4 GO:0003677 1/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RNDS4 GO:0000122 1/92 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RNDS4 GO:0030182 1/92 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8RNDS4 GO:0006366 1/92 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8RNDS4 GO:0003705 1/92 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8RNDS4 GO:0010629 1/92 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8RNDS4 GO:0045944 1/92 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RNDS4 GO:0070491 1/92 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8G1PZ0 GO:0016881 44/171 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8G1PZ0 GO:0004842 6/171 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8G1PZ0 GO:0005524 2/171 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G1PZ0 GO:0048477 1/171 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8G1PZ0 GO:0051276 1/171 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8G1PZ0 GO:0007140 1/171 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8G1PZ0 GO:0007067 1/171 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8G1PZ0 GO:0006511 1/171 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8G1PZ0 GO:0031647 1/171 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8G1PZ0 GO:0005515 1/171 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8G1PZ0 GO:0005875 1/171 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8G1PZ0 GO:0016567 1/171 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8G1PZ0 GO:0045676 1/171 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8G1PZ0 GO:0048132 1/171 female germ-line stem cell asymmetric division biological_process "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] EOG8G1PZ0 GO:0007286 1/171 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8G1PZ0 GO:0001745 1/171 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8G1PZ0 GO:0019915 1/171 lipid storage biological_process "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] EOG8G1PZ0 GO:0022008 1/171 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8G1PZ0 GO:0030718 1/171 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8G1PZ0 GO:0001751 1/171 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8G1PZ0 GO:0016322 1/171 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8G1PZ0 GO:0008054 1/171 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG80KBFS GO:0003676 4/15 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G1PZ3 GO:0007185 1/52 transmembrane receptor protein tyrosine phosphatase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8G1PZ3 GO:0004721 1/52 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8G1PZ3 GO:0002121 1/52 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8G1PZ3 GO:0005886 1/52 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8G1PZ3 GO:0048749 1/52 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8J9QF8 GO:0003677 8/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J9QF8 GO:0004518 8/18 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8J9QF8 GO:0005634 5/18 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J9QF8 GO:0016568 5/18 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8J9QF8 GO:0008270 3/18 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SN433 GO:0006084 26/109 acetyl-CoA metabolic process biological_process "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] EOG8SN433 GO:0003824 23/109 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN433 GO:0016740 2/109 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8SN433 GO:0003986 2/109 acetyl-CoA hydrolase activity molecular_function "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20292] EOG8SN433 GO:0022008 1/109 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SN433 GO:0005811 1/109 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8J9QF2 GO:0006351 1/21 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J9QF2 GO:0003677 1/21 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J9QF2 GO:0003899 1/21 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG85F04Z GO:0051539 1/9 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG85F04Z GO:0003906 1/9 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] EOG85F04Z GO:0022900 1/9 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG85F04Z GO:0006284 1/9 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG85F04Z GO:0016020 1/9 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85F04Z GO:0003677 1/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JHFX2 GO:0016491 25/129 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8JHFX2 GO:0004316 21/129 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8JHFX2 GO:0004303 5/129 estradiol 17-beta-dehydrogenase activity molecular_function "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] EOG85F04G GO:0005576 1/201 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85F04G GO:0046427 1/201 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8H74V2 GO:0016020 1/106 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8H74V2 GO:0005024 1/106 transforming growth factor beta-activated receptor activity molecular_function "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] EOG8G7FFP GO:0016021 2/68 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FFP GO:0004930 2/68 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8G7FFQ GO:0010038 28/89 response to metal ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] EOG85F04B GO:0016491 4/25 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG85F04B GO:0043565 1/25 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8N06V1 GO:0020037 1/69 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8N06V1 GO:0019825 1/69 oxygen binding molecular_function "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] EOG8N06V2 GO:0006886 18/85 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8N06V2 GO:0005634 18/85 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N06V2 GO:0003676 1/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8N06V9 GO:0016747 176/428 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8N06V9 GO:0022416 1/428 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8N06V9 GO:0035220 1/428 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8W3W35 GO:0016020 22/79 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8W3W35 GO:0004602 1/79 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8W3W35 GO:0006979 1/79 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG88GZK3 GO:0005840 2/80 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG88GZK3 GO:0003735 1/80 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG88GZK3 GO:0005763 1/80 mitochondrial small ribosomal subunit cellular_component "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] EOG88GZK3 GO:0006412 1/80 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8P5NRS GO:0008270 2/159 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8P5NRS GO:0003712 1/159 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8P5NRS GO:0004402 1/159 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8P5NRS GO:0003677 1/159 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P5NRS GO:0005634 1/159 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8P5NRS GO:0006355 1/159 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8P5NRW GO:0005524 24/56 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8P5NRW GO:0004674 21/56 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8P5NRW GO:0016020 5/56 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8P5NRW GO:0007049 5/56 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8P5NRW GO:0004672 3/56 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8P5NRW GO:0000086 1/56 G2/M transition of mitotic cell cycle biological_process "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] EOG8P5NRW GO:0000139 1/56 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8P5NRW GO:0004709 1/56 MAP kinase kinase kinase activity molecular_function "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] EOG8P5NRW GO:0007143 1/56 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8P5NRW GO:0007140 1/56 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8P5NRW GO:0006468 1/56 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8P5NRW GO:0045930 1/56 negative regulation of mitotic cell cycle biological_process "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P5NRW GO:0007284 1/56 spermatogonial cell division biological_process "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] EOG8P5NRW GO:0048142 1/56 germarium-derived cystoblast division biological_process "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] EOG8P5NRW GO:0045793 1/56 positive regulation of cell size biological_process "Any process that increases cell size." [GOC:go_curators] EOG8P5NRW GO:0046872 1/56 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8P5NRW GO:0004712 1/56 protein serine/threonine/tyrosine kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] EOG8P5NRW GO:0048137 1/56 spermatocyte division biological_process "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] EOG8P5NRW GO:0007126 1/56 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8P5NRW GO:0007095 1/56 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8P5NRW GO:0005794 1/56 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8QVFRW GO:0007264 26/105 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8QVFRW GO:0005089 25/105 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8QVFRW GO:0003677 24/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QVFRW GO:0005622 18/105 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8QVFRW GO:0005634 7/105 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QVFRW GO:0006334 7/105 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8QVFRW GO:0000786 7/105 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8QVFRW GO:0035022 1/105 positive regulation of Rac protein signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] EOG8QVFRW GO:0005088 1/105 Ras guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8QVFRW GO:0046579 1/105 positive regulation of Ras protein signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8QVFRW GO:0032314 1/105 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8QVFRW GO:0007015 1/105 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8QVFRW GO:0032318 1/105 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8QVFRW GO:0005515 1/105 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QVFRW GO:0045500 1/105 sevenless signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085] EOG8QVFRW GO:0007426 1/105 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8QVFRW GO:0008360 1/105 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8QVFRW GO:0016199 1/105 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8QVFRW GO:2000134 1/105 negative regulation of G1/S transition of mitotic cell cycle biological_process "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] EOG8QVFRW GO:0007480 1/105 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8QVFRW GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QVFRW GO:0008293 1/105 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8QVFRW GO:0030676 1/105 Rac guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8QVFRW GO:0008595 1/105 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8QVFRW GO:0031234 1/105 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG8QVFRW GO:0005829 1/105 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8N06VK GO:0003676 2/6 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG815JTB GO:0006826 6/50 iron ion transport biological_process "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG815JTB GO:0008199 6/50 ferric iron binding molecular_function "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] EOG815JTB GO:0005576 6/50 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG815JTB GO:0006879 6/50 cellular iron ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] EOG8SN43R GO:0016021 2/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG815JTG GO:0010587 6/91 miRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] EOG815JTG GO:0003723 6/91 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG815JTG GO:0000175 6/91 3'-5'-exoribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] EOG815JTG GO:0034427 6/91 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' biological_process "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah] EOG815JTG GO:1990074 6/91 polyuridylation-dependent mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588] EOG815JTG GO:0000932 6/91 cytoplasmic mRNA processing body cellular_component "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] EOG815JTG GO:0008859 2/91 exoribonuclease II activity molecular_function "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] EOG815JTG GO:0004527 1/91 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8J9QFP GO:0003676 15/55 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J9QFP GO:0006457 1/55 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8J9QFP GO:0016272 1/55 prefoldin complex cellular_component "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] EOG85TG4C GO:0018293 35/98 protein-FAD linkage biological_process "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] EOG85TG4C GO:0005739 35/98 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG85TG4C GO:0006121 33/98 mitochondrial electron transport, succinate to ubiquinone biological_process "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] EOG8G7FF4 GO:0000166 38/146 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8G7FF4 GO:0003676 37/146 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G7FF4 GO:0005515 1/146 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8G7FF4 GO:0005634 1/146 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G7FF4 GO:0071011 1/146 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8G7FF4 GO:0007067 1/146 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8G7FF4 GO:0008138 1/146 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8G7FF4 GO:0071013 1/146 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8G7FF4 GO:0035327 1/146 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8G7FF4 GO:0000398 1/146 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8G7FF4 GO:0004725 1/146 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8G7FF4 GO:0016607 1/146 nuclear speck cellular_component "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] EOG8G7FF4 GO:0005700 1/146 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8G7FF4 GO:0048024 1/146 regulation of mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] EOG8G7FF4 GO:0006376 1/146 mRNA splice site selection biological_process "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] EOG8G7FF4 GO:0000381 1/146 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8G7FF4 GO:0003729 1/146 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG815JTW GO:0005230 6/29 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG815JTW GO:0016021 6/29 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SN43M GO:0016747 2/7 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8SN43M GO:0016616 2/7 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8SN43M GO:0006633 2/7 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8SN43K GO:0005524 27/96 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SN43K GO:0004672 25/96 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8SN43K GO:0004579 2/96 dolichyl-diphosphooligosaccharide-protein glycotransferase activity molecular_function "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] EOG8SN43K GO:0004674 2/96 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8SN43K GO:0046982 1/96 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8SN43K GO:0051726 1/96 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8SN43K GO:0007370 1/96 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG8SN43K GO:0042803 1/96 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8SN43K GO:0045839 1/96 negative regulation of mitotic nuclear division biological_process "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] EOG8SN43K GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN43K GO:0007369 1/96 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8SN43K GO:2000060 1/96 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF] EOG8SN43K GO:0016301 1/96 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8DBWWC GO:0001682 1/63 tRNA 5'-leader removal biological_process "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] EOG8DBWWC GO:0004526 1/63 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8RV55R GO:0008270 21/75 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RV55R GO:0000381 1/75 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8RV55R GO:0005634 1/75 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RV55S GO:0016021 49/156 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV55S GO:0004930 47/156 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8RV55S GO:0008036 44/156 diuretic hormone receptor activity molecular_function "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling] EOG8RV55S GO:0005886 41/156 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RV55S GO:0008188 2/156 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8RV55S GO:0007186 2/156 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8RV55S GO:0007218 2/156 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8RV55S GO:0005887 2/156 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV55S GO:0004948 2/156 calcitonin receptor activity molecular_function "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645] EOG8RV55S GO:0009755 2/156 hormone-mediated signaling pathway biological_process "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] EOG8RV55S GO:0005184 2/156 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8RV55S GO:0009651 1/156 response to salt stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] EOG86HJRJ GO:0005811 1/84 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG86HJRN GO:0035556 1/8 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG86HJRN GO:0009190 1/8 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG86HJRN GO:0016849 1/8 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8FTZH9 GO:0003677 23/70 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FTZH9 GO:0003899 23/70 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8FTZH9 GO:0008270 23/70 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FTZH9 GO:0006351 22/70 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0005665 1/70 DNA-directed RNA polymerase II, core complex cellular_component "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8FTZH9 GO:0006360 1/70 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0006366 1/70 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8FTZH9 GO:0006383 1/70 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8FTZH9 GO:0005736 1/70 DNA-directed RNA polymerase I complex cellular_component "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8FTZH9 GO:0005666 1/70 DNA-directed RNA polymerase III complex cellular_component "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8RV55D GO:0060361 1/91 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG8RV55D GO:0008328 1/91 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8RV55D GO:0097106 1/91 postsynaptic density organization biological_process "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] EOG8RV55D GO:0007528 1/91 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8RV55D GO:0007274 1/91 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8RV55D GO:0097482 1/91 muscle cell postsynaptic density cellular_component "A postsynaptic density that is part of a muscle cell." [GOC:pr] EOG8RV55D GO:0035187 1/91 hatching behavior biological_process "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] EOG8RV55D GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RV55D GO:0051726 1/91 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8RV55D GO:0043113 1/91 receptor clustering biological_process "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460] EOG8RV55D GO:0040011 1/91 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8RV55D GO:0031594 1/91 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG86HJRS GO:0019318 76/195 hexose metabolic process biological_process "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] EOG86HJRS GO:0030246 76/195 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG86HJRS GO:0004034 60/195 aldose 1-epimerase activity molecular_function "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] EOG86HJRS GO:0016853 16/195 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG86HJRS GO:0005576 1/195 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RV55B GO:0003723 1/6 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RV55B GO:0005525 1/6 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8RV55B GO:0005622 1/6 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8RV55B GO:0003924 1/6 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG837TTQ GO:0004842 32/106 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG837TTQ GO:0008270 20/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG837TTQ GO:0005886 1/106 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG837TTQ GO:0030509 1/106 BMP signaling pathway biological_process "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034] EOG837TTQ GO:0004252 1/106 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG837TTQ GO:0040011 1/106 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG837TTQ GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG837TTQ GO:0005515 1/106 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG837TTQ GO:0007628 1/106 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG837TTQ GO:0016567 1/106 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG837TTQ GO:0006914 1/106 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG837TTQ GO:0016023 1/106 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG837TTQ GO:0045886 1/106 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG837TTQ GO:2000331 1/106 regulation of terminal button organization biological_process "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] EOG837TTQ GO:0008582 1/106 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG837TTQ GO:0050808 1/106 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG837TTQ GO:0006351 1/106 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG837TTQ GO:0030514 1/106 negative regulation of BMP signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] EOG870WZT GO:0005887 1/39 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84F8RN GO:0016021 1/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BGC9S GO:0005524 20/61 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BGC9S GO:0004817 18/61 cysteine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] EOG8BGC9S GO:0006423 18/61 cysteinyl-tRNA aminoacylation biological_process "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8BGC9S GO:0005737 4/61 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BGC9S GO:0004812 2/61 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8BGC9S GO:0006418 2/61 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG8BGC9S GO:0005829 1/61 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG870WZW GO:0006950 6/101 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG870WZW GO:0030018 1/101 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8S4RW5 GO:0016021 3/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RW5 GO:0004721 1/96 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8S4RW5 GO:0048812 1/96 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG83XXJC GO:0016740 3/372 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG83XXJC GO:0005634 1/372 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83XXJC GO:0008168 1/372 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG83XXJC GO:0008270 1/372 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83XXJC GO:0022008 1/372 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG83XXJC GO:0005737 1/372 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85HVBR GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85HVBR GO:0016887 1/11 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG85HVBR GO:0016491 1/11 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8BVV9D GO:0048812 1/64 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8BVV9D GO:0006974 1/64 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8BVV9D GO:0043524 1/64 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8BVV9D GO:0042127 1/64 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG879HMZ GO:0016772 69/190 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG879HMZ GO:0016301 11/190 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG879HMZ GO:0017022 1/190 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG879HMZ GO:0022008 1/190 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8RJJGQ GO:0008061 18/53 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8RJJGQ GO:0005576 18/53 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RJJGQ GO:0006030 18/53 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8CNT51 GO:0005576 3/34 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CNT51 GO:0040007 2/34 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8BGC9B GO:0004743 1/7 pyruvate kinase activity molecular_function "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] EOG8BGC9B GO:0000287 1/7 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8BGC9B GO:0030955 1/7 potassium ion binding molecular_function "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] EOG8BGC9B GO:0006096 1/7 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8CNT55 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CNT55 GO:0016887 1/6 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8GMXF1 GO:0016286 5/69 small conductance calcium-activated potassium channel activity molecular_function "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] EOG8GMXF1 GO:0016021 5/69 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GTNT7 GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GTNT7 GO:0005737 1/7 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GTNT7 GO:0006431 1/7 methionyl-tRNA aminoacylation biological_process "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8GTNT7 GO:0004825 1/7 methionine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] EOG8GTNT5 GO:0016706 2/64 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG8GTNT5 GO:0031418 2/64 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG8GTNT5 GO:0005506 2/64 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8GTNT5 GO:0019797 1/64 procollagen-proline 3-dioxygenase activity molecular_function "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] EOG8GTNT0 GO:0003676 5/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GTNT0 GO:0015074 4/105 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8GTNT0 GO:0008270 2/105 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BGC91 GO:0008236 1/34 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8BGC91 GO:0016020 1/34 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BGC91 GO:0007229 1/34 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8S4RWS GO:0006909 1/76 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8S4RWV GO:0008137 17/92 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8S4RWV GO:0042773 3/92 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8S4RWV GO:0016020 1/92 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RWV GO:0004129 1/92 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8S4RWV GO:0016021 1/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RWV GO:0008080 1/92 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8S4RWV GO:0005743 1/92 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8S4RWV GO:0070469 1/92 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8S4RWV GO:0005507 1/92 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8BGC99 GO:0006030 26/102 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8BGC99 GO:0005576 26/102 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BGC99 GO:0008061 26/102 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8BGC99 GO:0031012 1/102 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8BGC99 GO:0005201 1/102 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8GTNTC GO:0008270 8/29 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GTNTC GO:0016740 1/29 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8S4RWC GO:0008609 31/99 alkylglycerone-phosphate synthase activity molecular_function "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] EOG8S4RWC GO:0050660 30/99 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8S4RWC GO:0008610 30/99 lipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8S4RWC GO:0008762 30/99 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG8S4RWC GO:0005777 1/99 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8S4RWC GO:0016021 1/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RWC GO:0071949 1/99 FAD binding molecular_function "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] EOG8S4RWC GO:0008611 1/99 ether lipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] EOG8S4RWC GO:0016614 1/99 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8S4RWC GO:0005921 1/99 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG8S4RWC GO:0006811 1/99 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG83XXJ8 GO:0016787 29/77 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG83XXJ8 GO:0004067 5/77 asparaginase activity molecular_function "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] EOG83XXJ8 GO:0033345 2/77 asparagine catabolic process via L-aspartate biological_process "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] EOG83XXJ8 GO:0008798 2/77 beta-aspartyl-peptidase activity molecular_function "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] EOG83XXJ8 GO:0005737 2/77 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83XXJ8 GO:0003948 2/77 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity molecular_function "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547] EOG83XXJ8 GO:0035071 1/77 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG83XXJ8 GO:0048102 1/77 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8FXTPZ GO:0000166 26/88 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8FXTPZ GO:0003676 23/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FXTPZ GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FXTPZ GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FXTPZ GO:0045893 1/88 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8FXTPZ GO:0008134 1/88 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8FXTPZ GO:0007399 1/88 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8FXTPZ GO:0007474 1/88 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8FXTPZ GO:0044212 1/88 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG8FXTPZ GO:0003729 1/88 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8FXTPZ GO:0048477 1/88 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8S4RWK GO:0016798 25/117 hydrolase activity, acting on glycosyl bonds molecular_function "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] EOG8S4RWK GO:0016020 25/117 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RWK GO:0005975 4/117 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8S4RWK GO:0015991 2/117 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8S4RWK GO:0015078 2/117 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8S4RWK GO:0033179 2/117 proton-transporting V-type ATPase, V0 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG8S4RWK GO:0005811 1/117 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG83XXJ1 GO:0016787 15/58 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG83XXJ1 GO:0007632 1/58 visual behavior biological_process "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] EOG83XXJ1 GO:0008103 1/58 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG83XXJ1 GO:0007315 1/58 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG83XXJ1 GO:0007616 1/58 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG83XXJ1 GO:0048477 1/58 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG83XXJ1 GO:0007279 1/58 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG83XXJ1 GO:0007277 1/58 pole cell development biological_process "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] EOG83XXJ1 GO:0043488 1/58 regulation of mRNA stability biological_process "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] EOG83XXJ1 GO:0046011 1/58 regulation of oskar mRNA translation biological_process "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] EOG83XXJ1 GO:0040040 1/58 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG83XXJ1 GO:0019094 1/58 pole plasm mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG83XXJ1 GO:0007359 1/58 posterior abdomen determination biological_process "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG83XXJ1 GO:0008595 1/58 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG83XXJ1 GO:0043186 1/58 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG83XXJ1 GO:0007281 1/58 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG83XXJ1 GO:0030719 1/58 P granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] EOG83XXJ1 GO:0007314 1/58 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG83XXJ1 GO:0045727 1/58 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG83XXJ1 GO:0007318 1/58 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG83XXJ1 GO:0008542 1/58 visual learning biological_process "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] EOG83XXJ1 GO:0045495 1/58 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG83XXJ1 GO:0007275 1/58 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8HHRKW GO:0005576 2/101 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HHRKW GO:0008233 2/101 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8HHRKW GO:0005215 2/101 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8HHRKW GO:0048190 1/101 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8HHRKW GO:0030178 1/101 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8RV558 GO:0016476 1/100 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8RV558 GO:0007015 1/100 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8RV558 GO:0003383 1/100 apical constriction biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8RV558 GO:0016324 1/100 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8RV558 GO:0007160 1/100 cell-matrix adhesion biological_process "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] EOG86HJR2 GO:0070681 1/5 glutaminyl-tRNAGln biosynthesis via transamidation biological_process "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] EOG86HJR2 GO:0005739 1/5 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86HJR2 GO:0032543 1/5 mitochondrial translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] EOG86HJR2 GO:0016740 1/5 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG86HJR2 GO:0030956 1/5 glutamyl-tRNA(Gln) amidotransferase complex cellular_component "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] EOG86HJR2 GO:0016787 1/5 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG86HJR2 GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86HJR2 GO:0050567 1/5 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG898XGW GO:0046872 1/6 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG898XGW GO:0004784 1/6 superoxide dismutase activity molecular_function "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] EOG869TC0 GO:0004190 1/88 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG847J85 GO:0005525 1/11 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG847J85 GO:0003924 1/11 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG847J85 GO:0000287 1/11 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8S1WPP GO:0003677 9/32 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8S1WPP GO:0005634 8/32 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WPP GO:0016568 8/32 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8S1WPP GO:0004518 7/32 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8S1WPP GO:0008270 4/32 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S1WPP GO:0004527 1/32 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8M67XN GO:0016021 18/67 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M67XN GO:0022857 15/67 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8M67XN GO:0055085 3/67 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8M67XN GO:0008643 1/67 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8M67XN GO:0022008 1/67 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8JDKMQ GO:0007165 23/94 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8JDKMQ GO:0005622 22/94 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8JDKMQ GO:0005096 18/94 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8JDKMQ GO:0043547 1/94 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8JDKMQ GO:0032312 1/94 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8JDKMQ GO:0007480 1/94 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8JDKMQ GO:0008060 1/94 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8QJV4H GO:0005524 35/64 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QJV4H GO:0004674 31/64 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8QJV4H GO:0004713 2/64 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8QJV4H GO:0004672 2/64 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QJV4H GO:0003676 1/64 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV4H GO:0016887 1/64 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8M67XJ GO:0006511 31/101 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8M67XJ GO:0031461 30/101 cullin-RING ubiquitin ligase complex cellular_component "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] EOG8M67XJ GO:0007281 1/101 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG8M67XJ GO:0007528 1/101 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8M67XJ GO:0008582 1/101 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8M67XJ GO:0007293 1/101 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8M67XJ GO:0051726 1/101 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8M67XJ GO:0016360 1/101 sensory organ precursor cell fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG8M67XJ GO:0007295 1/101 growth of a germarium-derived egg chamber biological_process "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8M67XJ GO:0008285 1/101 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8M67XJ GO:0031466 1/101 Cul5-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] EOG8SBHCV GO:0005524 16/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SBHCV GO:0004672 15/97 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8SBHCV GO:0016772 2/97 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SBHCV GO:0005634 1/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SBHCV GO:0004674 1/97 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8SBHCV GO:0006468 1/97 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8SBHCV GO:0035556 1/97 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8G4K50 GO:0005506 29/76 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8G4K50 GO:0020037 29/76 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8G4K50 GO:0016705 27/76 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8G4K50 GO:0004497 26/76 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8G4K50 GO:0070330 2/76 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG8G4K50 GO:0005789 1/76 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG886BVX GO:0003729 28/83 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG886BVX GO:0005634 1/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG886BVX GO:0005515 1/83 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG886BVX GO:0007275 1/83 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG886BVX GO:0006398 1/83 histone mRNA 3'-end processing biological_process "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah] EOG886BVX GO:0005737 1/83 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG886BVX GO:0035613 1/83 RNA stem-loop binding molecular_function "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] EOG8PP105 GO:0007049 34/103 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8PP105 GO:0006221 13/103 pyrimidine nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8PP105 GO:0045747 1/103 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8PP105 GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PP105 GO:0006207 1/103 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG81G5M7 GO:0005509 31/95 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG81G5M7 GO:0032440 2/95 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG81G5M7 GO:0016459 1/95 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG81G5M7 GO:0060361 1/95 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG81G5M7 GO:0003012 1/95 muscle system process biological_process "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] EOG81G5M7 GO:0030239 1/95 myofibril assembly biological_process "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] EOG81G5M7 GO:0030016 1/95 myofibril cellular_component "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] EOG85XB93 GO:0006886 15/115 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG85XB93 GO:0016192 15/115 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG85XB93 GO:0030117 15/115 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG85XB93 GO:0007367 4/115 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG85XB93 GO:0045296 4/115 cadherin binding molecular_function "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] EOG85XB93 GO:0008134 3/115 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG85XB93 GO:0014017 3/115 neuroblast fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] EOG85XB93 GO:0005912 3/115 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG85XB93 GO:0016055 3/115 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG85XB93 GO:0007155 3/115 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG85XB93 GO:0030057 2/115 desmosome cellular_component "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] EOG85XB93 GO:0005667 2/115 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG85XB93 GO:0003713 2/115 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG85XB93 GO:0016342 2/115 catenin complex cellular_component "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] EOG85XB93 GO:0005916 2/115 fascia adherens cellular_component "A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910] EOG85XB93 GO:0005829 2/115 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG85XB93 GO:0005886 2/115 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85XB93 GO:0005198 2/115 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG85XB93 GO:0005915 2/115 zonula adherens cellular_component "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] EOG85XB93 GO:0003136 2/115 negative regulation of heart induction by canonical Wnt signaling pathway biological_process "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] EOG85XB93 GO:0019901 2/115 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG85XB93 GO:0048599 2/115 oocyte development biological_process "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] EOG85XB93 GO:0009898 2/115 cytoplasmic side of plasma membrane cellular_component "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] EOG85XB93 GO:0007399 2/115 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG85XB93 GO:0045294 2/115 alpha-catenin binding molecular_function "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf] EOG85XB93 GO:0000902 2/115 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG85XB93 GO:0016337 2/115 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG85XB93 GO:0007016 2/115 cytoskeletal anchoring at plasma membrane biological_process "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] EOG85XB93 GO:0030018 2/115 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG85XB93 GO:0016323 2/115 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG85XB93 GO:0000122 2/115 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0016324 1/115 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG85XB93 GO:0001745 1/115 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG85XB93 GO:0060914 1/115 heart formation biological_process "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] EOG85XB93 GO:0035147 1/115 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG85XB93 GO:0008360 1/115 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG85XB93 GO:0030720 1/115 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG85XB93 GO:0071896 1/115 protein localization to adherens junction biological_process "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:BHF, GOC:mah] EOG85XB93 GO:0035293 1/115 chitin-based larval cuticle pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG85XB93 GO:0048477 1/115 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG85XB93 GO:0016327 1/115 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG85XB93 GO:0045186 1/115 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG85XB93 GO:0048754 1/115 branching morphogenesis of an epithelial tube biological_process "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] EOG85XB93 GO:0007507 1/115 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG85XB93 GO:0035019 1/115 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG85XB93 GO:0019900 1/115 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG85XB93 GO:0072659 1/115 protein localization to plasma membrane biological_process "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] EOG85XB93 GO:0035017 1/115 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG85XB93 GO:0048526 1/115 imaginal disc-derived wing expansion biological_process "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] EOG85XB93 GO:0007163 1/115 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG85XB93 GO:0014019 1/115 neuroblast development biological_process "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] EOG85XB93 GO:0007370 1/115 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG85XB93 GO:0030139 1/115 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG85XB93 GO:0007391 1/115 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG85XB93 GO:0032403 1/115 protein complex binding molecular_function "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] EOG85XB93 GO:0005737 1/115 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85XB93 GO:0005914 1/115 spot adherens junction cellular_component "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] EOG85XB93 GO:0007472 1/115 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG85XB93 GO:0005634 1/115 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85XB93 GO:0007616 1/115 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG85XB93 GO:0045944 1/115 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0008092 1/115 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG85XB93 GO:0046530 1/115 photoreceptor cell differentiation biological_process "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] EOG85XB93 GO:0030707 1/115 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG85XB93 GO:0045893 1/115 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0035153 1/115 epithelial cell type specification, open tracheal system biological_process "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] EOG85XB93 GO:0060232 1/115 delamination biological_process "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] EOG85XB93 GO:0046667 1/115 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG85XB93 GO:0016331 1/115 morphogenesis of embryonic epithelium biological_process "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] EOG85XB93 GO:0030424 1/115 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG85XB93 GO:0007369 1/115 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG85XB93 GO:0005515 1/115 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB93 GO:0001709 1/115 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG87SVTX GO:0004252 1/8 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG85XB94 GO:0015846 1/6 polyamine transport biological_process "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] EOG85XB94 GO:0042597 1/6 periplasmic space cellular_component "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] EOG85XB94 GO:0005215 1/6 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG85XB94 GO:0019808 1/6 polyamine binding molecular_function "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai] EOG85XB95 GO:0003677 26/91 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85XB95 GO:0003682 25/91 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG85XB95 GO:0019185 1/91 snRNA-activating protein complex cellular_component "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] EOG85XB95 GO:0043565 1/91 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85XB95 GO:0042796 1/91 snRNA transcription from RNA polymerase III promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] EOG85XB95 GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG85XB95 GO:0003681 1/91 bent DNA binding molecular_function "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] EOG85XB95 GO:0065004 1/91 protein-DNA complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] EOG85XB95 GO:0042795 1/91 snRNA transcription from RNA polymerase II promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] EOG85XB95 GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB9K GO:0005578 143/527 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG85XB9K GO:0016055 142/527 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG85XB9K GO:0007275 138/527 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG85XB9K GO:0005109 5/527 frizzled binding molecular_function "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315] EOG85XB9K GO:0005615 5/527 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG85XB9K GO:0045165 4/527 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG85XB9K GO:0030182 3/527 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG85XB9K GO:0007367 2/527 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG85XB9K GO:0005576 2/527 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85XB9K GO:0048675 2/527 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG85XB9K GO:0044719 2/527 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG85XB9K GO:0005515 2/527 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB9K GO:0008544 1/527 epidermis development biological_process "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] EOG85XB9K GO:0048728 1/527 proboscis development biological_process "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc] EOG85XB9K GO:0060914 1/527 heart formation biological_process "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] EOG85XB9K GO:0001745 1/527 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG85XB9K GO:0050919 1/527 negative chemotaxis biological_process "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] EOG85XB9K GO:0035147 1/527 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG85XB9K GO:0007411 1/527 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG85XB9K GO:0061332 1/527 Malpighian tubule bud morphogenesis biological_process "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG85XB9K GO:0002168 1/527 instar larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG85XB9K GO:0035290 1/527 trunk segmentation biological_process "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] EOG85XB9K GO:0048190 1/527 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG85XB9K GO:0006355 1/527 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB9K GO:0005112 1/527 Notch binding molecular_function "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] EOG85XB9K GO:0005539 1/527 glycosaminoglycan binding molecular_function "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] EOG85XB9K GO:0035225 1/527 determination of genital disc primordium biological_process "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] EOG85XB9K GO:0061328 1/527 posterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10] EOG85XB9K GO:0007398 1/527 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG85XB9K GO:0007419 1/527 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG85XB9K GO:0030054 1/527 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG85XB9K GO:0005783 1/527 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG85XB9K GO:0072091 1/527 regulation of stem cell proliferation biological_process "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] EOG85XB9K GO:0048076 1/527 regulation of compound eye pigmentation biological_process "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG85XB9K GO:0007476 1/527 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG85XB9K GO:0007507 1/527 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG85XB9K GO:0048754 1/527 branching morphogenesis of an epithelial tube biological_process "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] EOG85XB9K GO:0046672 1/527 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG85XB9K GO:0007424 1/527 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG85XB9K GO:0035277 1/527 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG85XB9K GO:0005102 1/527 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG85XB9K GO:0060061 1/527 Spemann organizer formation biological_process "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph] EOG85XB9K GO:0007523 1/527 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG85XB9K GO:0035167 1/527 larval lymph gland hemopoiesis biological_process "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] EOG85XB9K GO:0035289 1/527 posterior head segmentation biological_process "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] EOG85XB9K GO:0005771 1/527 multivesicular body cellular_component "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] EOG85XB9K GO:0035017 1/527 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG85XB9K GO:0005886 1/527 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85XB9K GO:0051017 1/527 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG85XB9K GO:0050840 1/527 extracellular matrix binding molecular_function "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai] EOG85XB9K GO:0007394 1/527 dorsal closure, elongation of leading edge cells biological_process "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] EOG85XB9K GO:0007444 1/527 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG85XB9K GO:0060070 1/527 canonical Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] EOG85XB9K GO:0014019 1/527 neuroblast development biological_process "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] EOG85XB9K GO:0016015 1/527 morphogen activity molecular_function "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] EOG85XB9K GO:0007446 1/527 imaginal disc growth biological_process "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] EOG85XB9K GO:0003136 1/527 negative regulation of heart induction by canonical Wnt signaling pathway biological_process "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] EOG85XB9K GO:0035224 1/527 genital disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] EOG85XB9K GO:0035217 1/527 labial disc development biological_process "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] EOG85XB9K GO:0030139 1/527 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG85XB9K GO:0009996 1/527 negative regulation of cell fate specification biological_process "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] EOG85XB9K GO:0016204 1/527 determination of muscle attachment site biological_process "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] EOG85XB9K GO:0007448 1/527 anterior/posterior pattern specification, imaginal disc biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] EOG85XB9K GO:0032876 1/527 negative regulation of DNA endoreduplication biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] EOG85XB9K GO:0007391 1/527 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG85XB9K GO:0007435 1/527 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG85XB9K GO:0046847 1/527 filopodium assembly biological_process "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] EOG85XB9K GO:0008595 1/527 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG85XB9K GO:0010002 1/527 cardioblast differentiation biological_process "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG85XB9K GO:0043066 1/527 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG85XB9K GO:0035311 1/527 wing cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] EOG85XB9K GO:0016318 1/527 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG85XB9K GO:0045202 1/527 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG85XB9K GO:0007418 1/527 ventral midline development biological_process "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] EOG85XB9K GO:0045892 1/527 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB9K GO:0048542 1/527 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG85XB9K GO:0007442 1/527 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG85XB9K GO:0007616 1/527 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG85XB9K GO:0061382 1/527 Malpighian tubule tip cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213] EOG85XB9K GO:0042127 1/527 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG85XB9K GO:0035215 1/527 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG85XB9K GO:0007479 1/527 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG85XB9K GO:0016023 1/527 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG85XB9K GO:0005110 1/527 frizzled-2 binding molecular_function "Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb, PR:000007719] EOG85XB9K GO:0035220 1/527 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG85XB9K GO:0030707 1/527 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG85XB9K GO:0009986 1/527 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG85XB9K GO:0008284 1/527 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG85XB9K GO:0007423 1/527 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG85XB9K GO:0007346 1/527 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG85XB9K GO:0007447 1/527 imaginal disc pattern formation biological_process "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] EOG85XB9K GO:0042691 1/527 positive regulation of crystal cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] EOG85XB9K GO:0007223 1/527 Wnt signaling pathway, calcium modulating pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] EOG85XB9K GO:0035170 1/527 lymph gland crystal cell differentiation biological_process "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] EOG85XB9K GO:0048749 1/527 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG85XB9K GO:0035153 1/527 epithelial cell type specification, open tracheal system biological_process "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] EOG85XB9K GO:0007517 1/527 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG85XB9K GO:0007450 1/527 dorsal/ventral pattern formation, imaginal disc biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] EOG85XB9K GO:0061331 1/527 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG85XB9K GO:0035263 1/527 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG85XB9K GO:0030032 1/527 lamellipodium assembly biological_process "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] EOG85XB9K GO:0035288 1/527 anterior head segmentation biological_process "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] EOG85XB9K GO:0007498 1/527 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG85XB9K GO:0061320 1/527 pericardial nephrocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] EOG85XB9K GO:0045121 1/527 membrane raft cellular_component "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198] EOG85XB9K GO:0045611 1/527 negative regulation of hemocyte differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG85XB9K GO:0048332 1/527 mesoderm morphogenesis biological_process "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] EOG8HX7G0 GO:0043565 5/30 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8HX7G0 GO:0005634 5/30 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HX7G0 GO:0003700 5/30 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85XB9M GO:0005634 50/177 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85XB9M GO:0003707 49/177 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG85XB9M GO:0008270 44/177 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG85XB9M GO:0043565 42/177 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85XB9M GO:0006351 26/177 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG85XB9M GO:0003700 26/177 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG85XB9M GO:0004879 24/177 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG85XB9M GO:0003677 8/177 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85XB9M GO:0042803 2/177 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG85XB9M GO:0030522 2/177 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG85XB9M GO:0046982 2/177 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG85XB9M GO:0005515 2/177 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB9M GO:0008289 1/177 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG85XB9M GO:0007465 1/177 R7 cell fate commitment biological_process "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG85XB9M GO:0048813 1/177 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG85XB9M GO:0045892 1/177 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB9M GO:0007419 1/177 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG85XB9M GO:0071390 1/177 cellular response to ecdysone biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] EOG85XB9M GO:0007510 1/177 cardioblast cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG85XB9M GO:0042331 1/177 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG85XB9M GO:0005500 1/177 juvenile hormone binding molecular_function "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] EOG85XB9M GO:0045596 1/177 negative regulation of cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] EOG85XB9M GO:0001078 1/177 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG85XB9M GO:0048666 1/177 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG85XB9M GO:0007601 1/177 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG85XB9M GO:0035076 1/177 ecdysone receptor-mediated signaling pathway biological_process "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] EOG85XB9M GO:0007503 1/177 fat body development biological_process "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] EOG85XB9M GO:0005737 1/177 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85XB9M GO:0004884 1/177 ecdysteroid hormone receptor activity molecular_function "Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701] EOG85XB9M GO:0007298 1/177 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG85XB9M GO:0007281 1/177 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG85XB9M GO:0040034 1/177 regulation of development, heterochronic biological_process "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] EOG85XB9M GO:0007464 1/177 R3/R4 cell fate commitment biological_process "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG85XB9M GO:0000166 1/177 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG85XB9M GO:0007517 1/177 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG85XB9M GO:0061331 1/177 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG85XB9M GO:0008230 1/177 ecdysone receptor holocomplex cellular_component "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] EOG85XB9M GO:0042562 1/177 hormone binding molecular_function "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] EOG85XB9M GO:0000122 1/177 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB9M GO:0016319 1/177 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG85XB9M GO:0007270 1/177 neuron-neuron synaptic transmission biological_process "The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435] EOG85XB9M GO:0035075 1/177 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG85XB9M GO:0035073 1/177 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG85XB9M GO:0007462 1/177 R1/R6 cell fate commitment biological_process "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG85XB9M GO:0007507 1/177 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG85XB9M GO:0021782 1/177 glial cell development biological_process "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG85XB9M GO:0045944 1/177 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB9M GO:0046530 1/177 photoreceptor cell differentiation biological_process "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] EOG85XB9M GO:0030425 1/177 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG85XB9M GO:0008232 1/177 activator ecdysone receptor complex cellular_component "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] EOG85XB9M GO:0045893 1/177 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB9M GO:0004872 1/177 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG85XB9M GO:0016322 1/177 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG85XB9M GO:0001752 1/177 compound eye photoreceptor fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] EOG85XB9M GO:0005700 1/177 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG85XB9M GO:0000976 1/177 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8G4K5Q GO:0003824 1/6 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8G4K5Q GO:0030170 1/6 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8577Q9 GO:0006457 3/5 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8577Q9 GO:0003755 3/5 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8577Q9 GO:0008270 1/5 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G4K5V GO:0005887 1/75 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VDSDC GO:0005506 27/104 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8VDSDC GO:0006633 27/104 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8VDSDC GO:0016021 25/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VDSDC GO:0016491 24/104 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8VDSDC GO:0000254 3/104 C-4 methylsterol oxidase activity molecular_function "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] EOG8G4K5K GO:0008270 1/80 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G4K5M GO:0008817 1/39 cob(I)yrinic acid a,c-diamide adenosyltransferase activity molecular_function "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] EOG870WXG GO:0005515 1/38 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB9R GO:0017150 27/99 tRNA dihydrouridine synthase activity molecular_function "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] EOG85XB9R GO:0050660 27/99 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG85XB9R GO:0006412 1/99 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG85XB9R GO:0047465 1/99 N-acylglucosamine-6-phosphate 2-epimerase activity molecular_function "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] EOG85XB9R GO:0005840 1/99 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG85XB9R GO:0003735 1/99 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG85XB9P GO:0004531 31/91 deoxyribonuclease II activity molecular_function "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] EOG85XB9P GO:0005622 1/91 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG85XB9P GO:0006308 1/91 DNA catabolic process biological_process "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] EOG85XB9P GO:0045476 1/91 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG85XB9P GO:0006309 1/91 apoptotic DNA fragmentation biological_process "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] EOG8JT2MM GO:0003677 3/25 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JT2MM GO:0003676 2/25 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JT2MM GO:0008270 1/25 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R7XRW GO:0003723 2/10 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8R7XRW GO:0008173 1/10 RNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] EOG8R7XRW GO:0030743 1/10 rRNA (adenosine-2'-O-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66] EOG8R7XRW GO:0006396 1/10 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8JT2MB GO:0003723 1/11 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8JT2MB GO:0006520 1/11 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8JT2MB GO:0004252 1/11 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8JT2MB GO:0005215 1/11 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8JT2MB GO:0006207 1/11 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG8JT2MB GO:0055085 1/11 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8JT2MB GO:0001522 1/11 pseudouridine synthesis biological_process "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] EOG8JT2MB GO:0004070 1/11 aspartate carbamoyltransferase activity molecular_function "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016] EOG8JT2MB GO:0004190 1/11 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8JT2MB GO:0016597 1/11 amino acid binding molecular_function "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] EOG8JT2MB GO:0016020 1/11 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8JT2MB GO:0009982 1/11 pseudouridine synthase activity molecular_function "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] EOG87M4F5 GO:0005506 1/39 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG87M4F5 GO:0016705 1/39 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG87M4F5 GO:0020037 1/39 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG873S76 GO:0005840 26/91 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG873S76 GO:0003735 26/91 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG873S76 GO:0006412 26/91 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8JT2MV GO:0008168 1/4 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8CJZ01 GO:0000166 1/6 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CJZ01 GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJZ01 GO:0016849 1/6 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8CJZ01 GO:0035556 1/6 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8CJZ01 GO:0009190 1/6 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG87SVTP GO:0006915 29/109 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG87SVTP GO:0045786 29/109 negative regulation of cell cycle biological_process "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG87SVTP GO:0005912 1/109 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG87SVTP GO:0030296 1/109 protein tyrosine kinase activator activity molecular_function "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732] EOG87SVTP GO:0061098 1/109 positive regulation of protein tyrosine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] EOG87SVTP GO:0004623 1/109 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG88PQ04 GO:0004012 35/97 phospholipid-translocating ATPase activity molecular_function "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] EOG88PQ04 GO:0005524 35/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88PQ04 GO:0016021 35/97 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88PQ04 GO:0000287 35/97 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG88PQ04 GO:0019829 34/97 cation-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] EOG88PQ04 GO:0005388 1/97 calcium-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] EOG8NS5T4 GO:0016020 23/84 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NS5T4 GO:0003824 13/84 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8NS5T4 GO:0004346 10/84 glucose-6-phosphatase activity molecular_function "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16692] EOG8NS5T4 GO:0004930 7/84 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NS5T4 GO:0004984 7/84 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8NS5T4 GO:0016021 7/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5T4 GO:0005549 7/84 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG87SVTW GO:0005524 6/50 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87SVTW GO:0004674 5/50 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG87SVTW GO:0004709 1/50 MAP kinase kinase kinase activity molecular_function "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] EOG8NS5T9 GO:0016849 1/7 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8NS5T9 GO:0035556 1/7 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8NS5T9 GO:0009190 1/7 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8CRPGH GO:0005622 9/25 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8CRPGH GO:0005085 9/25 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8CRPGH GO:0007264 9/25 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG83R630 GO:0005506 4/10 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83R630 GO:0016705 4/10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83R630 GO:0020037 4/10 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83R630 GO:0004497 4/10 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG82Z75N GO:0004733 28/99 pyridoxamine-phosphate oxidase activity molecular_function "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] EOG82Z75N GO:0008615 28/99 pyridoxine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] EOG82Z75N GO:0010181 27/99 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG82Z75M GO:0000796 32/115 condensin complex cellular_component "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] EOG82Z75M GO:0007076 32/115 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG82Z75M GO:0008168 1/115 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG82Z75M GO:0070194 1/115 synaptonemal complex disassembly biological_process "The controlled breakdown of a synaptonemal complex." [GOC:mah] EOG82Z75M GO:0000819 1/115 sister chromatid segregation biological_process "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] EOG82Z75M GO:0005720 1/115 nuclear heterochromatin cellular_component "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732] EOG82Z75M GO:0000775 1/115 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG82Z75M GO:0000785 1/115 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG82Z75M GO:0022008 1/115 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82Z75M GO:0007052 1/115 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG82Z75M GO:0005634 1/115 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82Z75M GO:0000281 1/115 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG82Z75M GO:0000070 1/115 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8SXQV3 GO:0016787 4/102 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8SXQV3 GO:0008477 2/102 purine nucleosidase activity molecular_function "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] EOG82Z75B GO:0045454 17/80 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG82Z75C GO:0003700 35/139 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82Z75C GO:0005634 35/139 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82Z75C GO:0043565 30/139 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82Z75C GO:0000976 5/139 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG82Z75C GO:0004000 2/139 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG82Z75C GO:0007389 1/139 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG82Z75C GO:0007485 1/139 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG82Z75C GO:0007398 1/139 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG82Z75C GO:0007450 1/139 dorsal/ventral pattern formation, imaginal disc biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] EOG82Z75C GO:0007517 1/139 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG82Z75C GO:0035309 1/139 wing and notum subfield formation biological_process "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] EOG82Z75C GO:0009953 1/139 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG82Z75C GO:0010629 1/139 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG82Z75C GO:0042659 1/139 regulation of cell fate specification biological_process "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] EOG82Z75C GO:0006355 1/139 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82Z75C GO:0007420 1/139 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG82Z75C GO:0007419 1/139 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG82Z75C GO:0021782 1/139 glial cell development biological_process "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG82Z75C GO:0007476 1/139 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG82Z75C GO:0035222 1/139 wing disc pattern formation biological_process "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] EOG82Z75C GO:0007400 1/139 neuroblast fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] EOG82Z75C GO:0007417 1/139 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8GB9M9 GO:0000175 1/11 3'-5'-exoribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] EOG8GB9M9 GO:0003723 1/11 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GB9M9 GO:0006402 1/11 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG8GB9M9 GO:0004654 1/11 polyribonucleotide nucleotidyltransferase activity molecular_function "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] EOG8GB9M9 GO:0006396 1/11 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8N334P GO:0045596 5/97 negative regulation of cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] EOG8N334P GO:0008293 2/97 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8N334P GO:0005576 1/97 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8N334P GO:0005122 1/97 torso binding molecular_function "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] EOG8N334P GO:0018445 1/97 prothoracicotrophic hormone activity molecular_function "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403] EOG8N334P GO:0008595 1/97 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8N334P GO:0008358 1/97 maternal determination of anterior/posterior axis, embryo biological_process "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8N334P GO:0007362 1/97 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8N334P GO:0046957 1/97 negative phototaxis biological_process "The directed movement of a cell or organism away from a source of light." [GOC:ai] EOG8N334P GO:0043196 1/97 varicosity cellular_component "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] EOG8N334P GO:0007552 1/97 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG8N334P GO:0044060 1/97 regulation of endocrine process biological_process "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] EOG8N334P GO:0005179 1/97 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG8GB9M1 GO:0005576 26/94 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GB9M1 GO:0005509 26/94 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GB9M1 GO:0007155 25/94 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8GB9M1 GO:0001558 1/94 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG8GB9M1 GO:0033627 1/94 cell adhesion mediated by integrin biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] EOG8GB9M1 GO:0016203 1/94 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8GB9M1 GO:0007517 1/94 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8GB9M1 GO:0043234 1/94 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8GB9M1 GO:0005927 1/94 muscle tendon junction cellular_component "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] EOG8GB9M1 GO:0008201 1/94 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8GB9M1 GO:0031012 1/94 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8M9457 GO:0007268 26/130 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8M9457 GO:0019992 26/130 diacylglycerol binding molecular_function "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] EOG8M9457 GO:0046872 20/130 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M9457 GO:0035556 20/130 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8M9457 GO:0008021 1/130 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8M9457 GO:0007269 1/130 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8M9457 GO:0016079 1/130 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8M9457 GO:0045211 1/130 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8M9457 GO:0016082 1/130 synaptic vesicle priming biological_process "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] EOG8M9457 GO:0005516 1/130 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8M9457 GO:0043195 1/130 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8GB9M7 GO:0031463 1/174 Cul3-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] EOG8GB9M7 GO:0006919 1/174 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8GB9M7 GO:0007291 1/174 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8GB9M7 GO:0016567 1/174 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8C2KS8 GO:0042060 1/82 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8C2KS0 GO:0003677 3/9 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C2KS0 GO:0015074 2/9 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8C2KS0 GO:0006310 2/9 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8Z655V GO:0043565 4/23 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8Z655V GO:0003700 4/23 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8Z655V GO:0005634 1/23 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZCWMQ GO:0000723 130/891 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8ZCWMQ GO:0006281 130/891 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8ZCWMQ GO:0003678 130/891 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8ZCWMQ GO:0005524 46/891 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZCWMQ GO:0004386 20/891 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8ZCWMQ GO:0003676 5/891 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZCWMQ GO:0005634 2/891 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZCWMQ GO:0003677 2/891 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZCWMQ GO:0008234 1/891 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8ZCWMQ GO:0006508 1/891 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8ZCWMQ GO:0008270 1/891 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZCWMQ GO:0046872 1/891 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GB9MX GO:0005525 2/17 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8GB9MX GO:0005737 1/17 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GB9MX GO:0005524 1/17 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GB9MX GO:0016887 1/17 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8GB9MX GO:0043023 1/17 ribosomal large subunit binding molecular_function "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators] EOG8GB9MX GO:0043022 1/17 ribosome binding molecular_function "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] EOG8GB9MZ GO:0050660 281/974 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8GB9MZ GO:0008812 249/974 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8GB9MZ GO:0006066 249/974 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8GB9MZ GO:0016614 32/974 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8GB9MZ GO:0004198 12/974 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8GB9MZ GO:0005622 12/974 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8GB9MZ GO:0004344 11/974 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG8GB9MZ GO:0005509 10/974 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GB9MZ GO:0016491 9/974 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GB9MZ GO:0045455 9/974 ecdysteroid metabolic process biological_process "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] EOG8GB9MZ GO:0008270 1/974 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GB9MZ GO:0006915 1/974 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8GB9MZ GO:0042600 1/974 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8GB9MZ GO:0004190 1/974 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8GB9MZ GO:0003676 1/974 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9MZ GO:0004197 1/974 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8GB9MZ GO:0046331 1/974 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8GB9MZ GO:0015074 1/974 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8HDW95 GO:0010181 53/154 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8HDW95 GO:0016491 35/154 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8HDW95 GO:0052854 18/154 medium-chain-(S)-2-hydroxy-acid oxidase activity molecular_function "Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons." [EC:1.1.3.15] EOG8HDW95 GO:0052853 18/154 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity molecular_function "Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons." [EC:1.1.3.15] EOG8HDW95 GO:0052852 18/154 very-long-chain-(S)-2-hydroxy-acid oxidase activity molecular_function "Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons." [EC:1.1.3.15] EOG8HDW95 GO:0005777 1/154 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8SR09H GO:0004842 24/100 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8SR09H GO:0008270 8/100 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR09H GO:0022008 1/100 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SR09H GO:0042752 1/100 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG8GB9MT GO:0005643 2/7 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG81VNN1 GO:0016853 1/5 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8NW20Q GO:0005634 42/146 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NW20Q GO:0003700 41/146 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NW20Q GO:0045944 2/146 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NW20Q GO:0008063 2/146 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8NW20Q GO:0035206 2/146 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8NW20Q GO:0006955 2/146 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8NW20Q GO:0043565 2/146 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NW20Q GO:0006952 2/146 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8NW20Q GO:0001077 2/146 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8NW20Q GO:0006964 2/146 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8NW20Q GO:0042387 2/146 plasmatocyte differentiation biological_process "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] EOG8NW20Q GO:0005515 2/146 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NW20Q GO:0048935 2/146 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG8NW20Q GO:0005737 2/146 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NW20Q GO:0000381 1/146 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8NW20Q GO:0006974 1/146 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8NW20Q GO:0007507 1/146 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8NW20Q GO:0006967 1/146 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8NW20Q GO:0045893 1/146 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NW20Q GO:0009953 1/146 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8NW20Q GO:0010629 1/146 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8NW20Q GO:0010004 1/146 gastrulation involving germ band extension biological_process "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8NW20Q GO:0010628 1/146 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8NW20Q GO:0006366 1/146 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8NW20Q GO:0050830 1/146 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8NW20Q GO:0007498 1/146 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8NW20Q GO:0035070 1/146 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8NW20Q GO:0000122 1/146 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NW20Q GO:0007369 1/146 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8NW20Q GO:0008354 1/146 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8NW20Q GO:0009952 1/146 anterior/posterior pattern specification biological_process "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8NW20Q GO:0003677 1/146 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NW20Q GO:0007501 1/146 mesodermal cell fate specification biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] EOG8NW20Q GO:0002781 1/146 antifungal peptide production biological_process "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] EOG8NW20Q GO:0009620 1/146 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG8NW20Q GO:0000977 1/146 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG8NW20Q GO:0009950 1/146 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8NW20Q GO:0007398 1/146 ectoderm development biological_process "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] EOG8NW20Q GO:0070491 1/146 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8NW20Q GO:0031594 1/146 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8NW20Q GO:0045087 1/146 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8NW20Q GO:0001715 1/146 ectodermal cell fate specification biological_process "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] EOG8NW20Q GO:0006355 1/146 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NW20Q GO:0050832 1/146 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8NW20Q GO:0007419 1/146 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8NW20Q GO:0070379 1/146 high mobility group box 1 binding molecular_function "Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461] EOG8NW20Q GO:0045892 1/146 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NW20Q GO:0035006 1/146 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8NW20Q GO:0035171 1/146 lamellocyte differentiation biological_process "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] EOG8ZCWM0 GO:0008076 30/110 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8ZCWM0 GO:0005249 30/110 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8ZCWM0 GO:0051260 26/110 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8ZCWM0 GO:0008345 1/110 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8ZCWM0 GO:0060025 1/110 regulation of synaptic activity biological_process "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] EOG8ZCWM0 GO:0048675 1/110 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8ZCWM0 GO:0016021 1/110 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZCWM0 GO:0045187 1/110 regulation of circadian sleep/wake cycle, sleep biological_process "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] EOG8ZCWM0 GO:0030431 1/110 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8ZCWM0 GO:0048150 1/110 behavioral response to ether biological_process "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid] EOG8ZCWM0 GO:0048047 1/110 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8ZCWM0 GO:0009584 1/110 detection of visible light biological_process "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8ZCWM0 GO:0007637 1/110 proboscis extension reflex biological_process "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] EOG8ZCWM0 GO:0050909 1/110 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8ZCWM0 GO:0001508 1/110 action potential biological_process "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] EOG8ZCWM0 GO:0007619 1/110 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8ZCWM0 GO:0022843 1/110 voltage-gated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8ZCWM0 GO:0005251 1/110 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8ZCWM0 GO:0007611 1/110 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8ZCWM0 GO:0007629 1/110 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8ZCWM0 GO:0006813 1/110 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8GB9MG GO:0004725 20/72 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8GB9MG GO:0046872 15/72 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GB9MG GO:0008138 1/72 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8GB9MG GO:0006470 1/72 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8GB9MG GO:0000285 1/72 1-phosphatidylinositol-3-phosphate 5-kinase activity molecular_function "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612] EOG8DZ4BD GO:0016021 7/12 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DZ4BD GO:0004930 7/12 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DZ4BD GO:0004715 1/12 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8M945H GO:0005507 5/39 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8M945H GO:0016491 4/39 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8M945H GO:0008447 1/39 L-ascorbate oxidase activity molecular_function "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] EOG83R63X GO:0005634 2/6 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83R63X GO:0003700 2/6 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG83R63X GO:0043565 1/6 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83R63X GO:0000976 1/6 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG82Z752 GO:0003676 2/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82Z752 GO:0008270 1/18 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82Z752 GO:0046872 1/18 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82Z752 GO:0006351 1/18 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82Z752 GO:0003677 1/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82Z752 GO:0003899 1/18 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8H48KB GO:0016021 9/61 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H48KB GO:0005375 9/61 copper ion transmembrane transporter activity molecular_function "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] EOG8X6FQ5 GO:0003924 19/50 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8X6FQ5 GO:0005525 19/50 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8X6FQ5 GO:0003746 3/50 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8X6FQ5 GO:0006451 1/50 translational readthrough biological_process "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232] EOG8X6FQ5 GO:0006184 1/50 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8X6FQ5 GO:0006414 1/50 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8M945Z GO:0006810 24/99 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8M945Z GO:0007067 24/99 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8M945Z GO:0005874 23/99 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8M945Z GO:0005737 23/99 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8M945Z GO:0000132 22/99 establishment of mitotic spindle orientation biological_process "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] EOG8M945Z GO:0005875 21/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8M945Z GO:0006928 21/99 movement of cell or subcellular component biological_process "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] EOG8M945Z GO:0005815 21/99 microtubule organizing center cellular_component "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] EOG8M945Z GO:0016787 3/99 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8M945Z GO:0030706 1/99 germarium-derived oocyte differentiation biological_process "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8M945Z GO:0030424 1/99 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8M945Z GO:0043025 1/99 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8M945Z GO:0007018 1/99 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8M945Z GO:0030381 1/99 chorion-containing eggshell pattern formation biological_process "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] EOG8M945Z GO:0030425 1/99 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8M945Z GO:0030234 1/99 enzyme regulator activity molecular_function "Binds to and modulates the activity of an enzyme." [GOC:mah] EOG8M945Z GO:0046716 1/99 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8M945Z GO:0030473 1/99 nuclear migration along microtubule biological_process "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] EOG8M945Z GO:0030723 1/99 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8M945Z GO:0005813 1/99 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8M945Z GO:0030716 1/99 oocyte fate determination biological_process "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] EOG8M945Z GO:0051383 1/99 kinetochore organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8M945Z GO:0007312 1/99 oocyte nucleus migration involved in oocyte dorsal/ventral axis specification biological_process "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] EOG8M945Z GO:0016740 1/99 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8M945Z GO:0007303 1/99 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8M945Z GO:0046843 1/99 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8M945Z GO:0051299 1/99 centrosome separation biological_process "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] EOG8M945Z GO:0048814 1/99 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8M945Z GO:0051647 1/99 nucleus localization biological_process "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8M945Z GO:0007294 1/99 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8M945Z GO:0006200 1/99 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8M945Z GO:0042052 1/99 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8M945Z GO:0007298 1/99 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8M945Z GO:0000776 1/99 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG8M945Z GO:0051225 1/99 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8M945Z GO:0010970 1/99 microtubule-based transport biological_process "Microtubule-based movement that results in the net, directed movement of organelles or other particles from one location in the cell to another." [GOC:dph, GOC:mah, GOC:tb] EOG8M945Z GO:0000777 1/99 condensed chromosome kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] EOG8M945Z GO:0007093 1/99 mitotic cell cycle checkpoint biological_process "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] EOG8M945Z GO:0034501 1/99 protein localization to kinetochore biological_process "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] EOG8M945Z GO:0042623 1/99 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8M945Z GO:0005938 1/99 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8M945Z GO:0043143 1/99 regulation of translation by machinery localization biological_process "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] EOG8M945Z GO:0051642 1/99 centrosome localization biological_process "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8M945Z GO:0016319 1/99 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8M945Z GO:0008088 1/99 axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] EOG8M945Z GO:0007405 1/99 neuroblast proliferation biological_process "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] EOG8M945Z GO:0000922 1/99 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8M945Z GO:0030286 1/99 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8M945Z GO:0048142 1/99 germarium-derived cystoblast division biological_process "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] EOG8M945Z GO:0005828 1/99 kinetochore microtubule cellular_component "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] EOG8M945Z GO:0008104 1/99 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8M945Z GO:0019827 1/99 stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] EOG8M945Z GO:0048135 1/99 female germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240] EOG8M945Z GO:0045478 1/99 fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] EOG8M945Z GO:0007283 1/99 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8M945Z GO:0005869 1/99 dynactin complex cellular_component "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] EOG8M945Z GO:0016358 1/99 dendrite development biological_process "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8M945Z GO:0072499 1/99 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG8M945Z GO:0008298 1/99 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8M945Z GO:0030510 1/99 regulation of BMP signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] EOG8M945Z GO:0007097 1/99 nuclear migration biological_process "The directed movement of the nucleus." [GOC:ai] EOG8M945Z GO:0048477 1/99 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8M945Z GO:0045502 1/99 dynein binding molecular_function "Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf] EOG8M945Z GO:0048813 1/99 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8M945Z GO:0031616 1/99 spindle pole centrosome cellular_component "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] EOG8M945Z GO:2001019 1/99 positive regulation of retrograde axon cargo transport biological_process "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] EOG8M945Z GO:0006886 1/99 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8M945Z GO:0050790 1/99 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8X6FQ6 GO:0008270 2/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X6FQ6 GO:0016571 1/94 histone methylation biological_process "The modification of histones by addition of methyl groups." [GOC:ai] EOG8X6FQ6 GO:0016787 1/94 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8X6FQ6 GO:0051568 1/94 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8X6FQ6 GO:0002805 1/94 regulation of antimicrobial peptide biosynthetic process biological_process "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] EOG8X6FQ6 GO:0009880 1/94 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8X6FQ6 GO:0007448 1/94 anterior/posterior pattern specification, imaginal disc biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] EOG8X6FQ6 GO:0044666 1/94 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8NS5TG GO:0035208 1/89 positive regulation of hemocyte proliferation biological_process "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8CJZ0H GO:0008033 18/41 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8CJZ0H GO:0004540 18/41 ribonuclease activity molecular_function "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] EOG8SXQVP GO:0016805 70/301 dipeptidase activity molecular_function "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] EOG8SXQVP GO:0031225 70/301 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8SXQVP GO:0046872 70/301 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SXQVP GO:0008237 40/301 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8SXQVP GO:0008239 30/301 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8SXQVP GO:0008235 30/301 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG8CJZ0M GO:0007275 7/34 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8CJZ0M GO:0016021 7/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJZ0M GO:0007219 7/34 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8X6FQ8 GO:0043565 9/38 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8X6FQ8 GO:0003700 9/38 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8X6FQ8 GO:0005634 8/38 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8X6FQ8 GO:0003677 2/38 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X6FQ8 GO:0006909 1/38 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8X6FQ8 GO:2000179 1/38 positive regulation of neural precursor cell proliferation biological_process "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] EOG8X6FQ8 GO:0001748 1/38 optic lobe placode development biological_process "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] EOG87M4HT GO:0016757 2/8 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG87M4HT GO:0005975 2/8 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8M945T GO:0016021 82/190 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M945T GO:0022857 58/190 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8M945T GO:0055085 24/190 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8M945T GO:0005215 10/190 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG88PQ2X GO:0003700 1/7 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG88PQ2X GO:0000156 1/7 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG88PQ2X GO:0005215 1/7 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG88PQ2X GO:0003677 1/7 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P5NSZ GO:0030246 1/8 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8909S1 GO:0007173 1/74 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG8909S1 GO:0005154 1/74 epidermal growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] EOG8909S1 GO:0007298 1/74 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8909S1 GO:0008586 1/74 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8909S1 GO:0005576 1/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8909S1 GO:0007267 1/74 cell-cell signaling biological_process "Any process that mediates the transfer of information from one cell to another." [GOC:mah] EOG8909S1 GO:0007477 1/74 notum development biological_process "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] EOG8909S1 GO:0008284 1/74 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG8909S1 GO:0016203 1/74 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8909S1 GO:0007476 1/74 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8909S1 GO:0007479 1/74 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8909S1 GO:0030031 1/74 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8909S1 GO:0045742 1/74 positive regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8909S1 GO:0008355 1/74 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8909S1 GO:0005515 1/74 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8909S1 GO:0035310 1/74 notum cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] EOG8909S1 GO:0008201 1/74 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8909S1 GO:0007420 1/74 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8909S1 GO:0007494 1/74 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8909S1 GO:0007482 1/74 haltere development biological_process "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] EOG8909S1 GO:0007474 1/74 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8909S1 GO:0007422 1/74 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8909S1 GO:0043066 1/74 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG87DCZ7 GO:0016740 1/4 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG87DCZ7 GO:0003723 1/4 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87DCZ7 GO:0006955 1/4 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG87DCZ7 GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TB6TF GO:0009103 21/43 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG8TB6TF GO:0008781 3/43 N-acylneuraminate cytidylyltransferase activity molecular_function "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] EOG8TB6TF GO:0009408 1/43 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8TB6TF GO:0016779 1/43 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8TB6TF GO:0007268 1/43 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8TB6TF GO:0005802 1/43 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG8909S5 GO:0005622 34/99 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8909S5 GO:0006915 33/99 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8909S5 GO:0005515 2/99 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8909S5 GO:0042981 1/99 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8909S5 GO:0045476 1/99 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8909S5 GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8909S5 GO:0043066 1/99 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG85QKTB GO:0032440 1/12 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG85QKTB GO:0005524 1/12 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85QKTB GO:0006457 1/12 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8XKXN8 GO:0030726 1/139 male germline ring canal formation biological_process "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] EOG8XKXN8 GO:0007112 1/139 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8XKXN8 GO:0008017 1/139 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8XKXN8 GO:0007067 1/139 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8XKXN8 GO:0048477 1/139 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8XKXN8 GO:0070938 1/139 contractile ring cellular_component "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] EOG8XKXN8 GO:0031106 1/139 septin ring organization biological_process "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] EOG8XKXN8 GO:0008356 1/139 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8XKXN8 GO:0007349 1/139 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8XKXN8 GO:0000281 1/139 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8XKXN8 GO:0005634 1/139 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XKXN8 GO:0003676 1/139 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XKXN8 GO:0005826 1/139 actomyosin contractile ring cellular_component "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] EOG8XKXN8 GO:0017022 1/139 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8XKXN8 GO:0051297 1/139 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8XKXN8 GO:0000915 1/139 actomyosin contractile ring assembly biological_process "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] EOG8XKXN8 GO:0005737 1/139 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XKXN8 GO:0007126 1/139 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8XKXN8 GO:0051533 1/139 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8XKXN8 GO:0007279 1/139 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8XKXN8 GO:0000910 1/139 cytokinesis biological_process "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] EOG8XKXN8 GO:0043063 1/139 intercellular bridge organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid] EOG8XKXN8 GO:0007009 1/139 plasma membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8XKXN8 GO:0045172 1/139 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8XKXN8 GO:0005515 1/139 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XKXN8 GO:0035323 1/139 male germline ring canal cellular_component "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420] EOG8XKXN8 GO:0045035 1/139 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG8XKXN8 GO:0022008 1/139 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8XKXN8 GO:0046872 1/139 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XKXN8 GO:0032189 1/139 maintenance of actomyosin contractile ring localization biological_process "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] EOG8XKXN8 GO:0008104 1/139 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8XKXN8 GO:0003779 1/139 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8XKXN8 GO:0007423 1/139 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8MGVQ1 GO:0005328 1/21 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8MGVQ1 GO:0016021 1/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85QKTN GO:0003950 1/59 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG85QKTS GO:0016020 18/93 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85QKTS GO:0008045 1/93 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8KM1H5 GO:0051539 24/91 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8KM1H5 GO:0009451 24/91 RNA modification biological_process "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] EOG8KM1H5 GO:0016740 23/91 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8KM1H5 GO:0032440 2/91 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8KM1H5 GO:0003824 2/91 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KM1H5 GO:0000079 1/91 regulation of cyclin-dependent protein serine/threonine kinase activity biological_process "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] EOG8KM1H5 GO:0046872 1/91 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KM1H5 GO:0051536 1/91 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8KPWTF GO:0005887 2/94 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KPWTF GO:0016829 2/94 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8MGVQJ GO:0051568 1/78 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8MGVQJ GO:0044666 1/78 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8MGVQJ GO:0048188 1/78 Set1C/COMPASS complex cellular_component "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] EOG8MGVQJ GO:0030317 1/78 sperm motility biological_process "Any process involved in the controlled movement of a sperm cell." [GOC:jl] EOG8MGVQJ GO:0046331 1/78 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8MGVQJ GO:0006351 1/78 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8MGVQJ GO:0006355 1/78 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8KM1HX GO:0050660 1/3 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8KM1HX GO:0045454 1/3 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8KM1HX GO:0004148 1/3 dihydrolipoyl dehydrogenase activity molecular_function "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] EOG85QKT5 GO:0016021 23/182 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85QKT5 GO:0005216 23/182 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG85QKT5 GO:0045924 1/182 regulation of female receptivity biological_process "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] EOG85QKT5 GO:0042048 1/182 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG85QKT5 GO:0008049 1/182 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG85QKT5 GO:0005227 1/182 calcium activated cation channel activity molecular_function "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] EOG85QKT5 GO:0070588 1/182 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG85QKT5 GO:0050965 1/182 detection of temperature stimulus involved in sensory perception of pain biological_process "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG85QKT5 GO:0050974 1/182 detection of mechanical stimulus involved in sensory perception biological_process "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG85QKT5 GO:0048060 1/182 negative gravitaxis biological_process "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] EOG85QKT5 GO:0019233 1/182 sensory perception of pain biological_process "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/] EOG85QKT5 GO:0005262 1/182 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG85QKT5 GO:0034704 1/182 calcium channel complex cellular_component "An ion channel complex through which calcium ions pass." [GOC:mah] EOG85QKT5 GO:0009612 1/182 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG85QKT5 GO:0008016 1/182 regulation of heart contraction biological_process "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] EOG85QKT5 GO:0050966 1/182 detection of mechanical stimulus involved in sensory perception of pain biological_process "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG85QKT5 GO:0007638 1/182 mechanosensory behavior biological_process "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] EOG85QKT5 GO:0050960 1/182 detection of temperature stimulus involved in thermoception biological_process "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos] EOG85QKT5 GO:0009408 1/182 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG85QKT5 GO:0006816 1/182 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG85QKT5 GO:0007620 1/182 copulation biological_process "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] EOG85QKT5 GO:0048266 1/182 behavioral response to pain biological_process "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] EOG85QKT5 GO:0007631 1/182 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8TQPS1 GO:0008270 1/11 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TQPS1 GO:0002100 1/11 tRNA wobble adenosine to inosine editing biological_process "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] EOG8TQPS1 GO:0008251 1/11 tRNA-specific adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] EOG8KM1HS GO:0006629 3/10 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8KM1HS GO:0006071 3/10 glycerol metabolic process biological_process "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] EOG8KM1HS GO:0008889 3/10 glycerophosphodiester phosphodiesterase activity molecular_function "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] EOG8KM1HR GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1HR GO:0003677 1/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8KM1HR GO:0006265 1/4 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG8KM1HR GO:0003918 1/4 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] EOG8KM1HR GO:0005694 1/4 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8KM1HQ GO:0003743 25/88 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8KM1HQ GO:0022008 1/88 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KM1HQ GO:0006413 1/88 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] EOG8KM1HQ GO:0005525 1/88 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8KM1HQ GO:0005829 1/88 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG88D3CJ GO:0003723 4/27 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG88D3CJ GO:0003964 4/27 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG87DCZV GO:0006919 6/32 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG87DCZV GO:0005739 6/32 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG87DCZV GO:0005840 1/32 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8BGCBC GO:0005272 54/94 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8BGCBC GO:0016021 52/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BGCBC GO:0016020 2/94 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BGCBC GO:0035199 1/94 salt aversion biological_process "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] EOG8BGCBC GO:0035002 1/94 liquid clearance, open tracheal system biological_process "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] EOG8BGCBC GO:0009651 1/94 response to salt stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] EOG8BGCBC GO:0050914 1/94 sensory perception of salty taste biological_process "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8TB6T0 GO:0004412 1/3 homoserine dehydrogenase activity molecular_function "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] EOG8TB6T0 GO:0050661 1/3 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG8TB6T0 GO:0004072 1/3 aspartate kinase activity molecular_function "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779] EOG8TB6T0 GO:0009067 1/3 aspartate family amino acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] EOG8CG2PM GO:0016772 61/86 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8JQ6BN GO:0003887 2/11 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8JQ6BN GO:0003677 2/11 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FXTND GO:0046872 5/104 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FXTND GO:0004842 1/104 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8FXTND GO:0000151 1/104 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG8XSP6B GO:0003676 57/550 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XSP6B GO:0008270 55/550 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XSP6B GO:0003723 11/550 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8XSP6B GO:0003964 11/550 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8XSP6B GO:0004190 5/550 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8XSP6B GO:0005882 4/550 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8XSP6B GO:0005198 4/550 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8XSP6B GO:0006355 1/550 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8XSP6B GO:0016787 1/550 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XSP6B GO:0015074 1/550 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8XSP6B GO:0005634 1/550 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PCD80 GO:0003964 2/12 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8PCD80 GO:0003723 1/12 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FXTNV GO:0051536 2/6 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8FXTNV GO:0009228 2/6 thiamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] EOG8FXTNV GO:0004789 1/6 thiamine-phosphate diphosphorylase activity molecular_function "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22331] EOG8DZ493 GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DZ493 GO:0006457 1/11 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8DZ493 GO:0009408 1/11 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8DZ493 GO:0046872 1/11 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DZ47Z GO:0005509 23/96 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DZ47Z GO:0035003 1/96 subapical complex cellular_component "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] EOG8DZ47Z GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DZ47Z GO:0007163 1/96 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8DZ47Z GO:0035330 1/96 regulation of hippo signaling biological_process "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] EOG8DZ47Z GO:0005524 1/96 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DZ47Z GO:0005886 1/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8DZ47Z GO:0045570 1/96 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG8DZ47Z GO:0045494 1/96 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG8DZ47Z GO:0016332 1/96 establishment or maintenance of polarity of embryonic epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] EOG8DZ47Z GO:0042051 1/96 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG8DZ47Z GO:0016334 1/96 establishment or maintenance of polarity of follicular epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] EOG8DZ47Z GO:0045746 1/96 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8DZ47Z GO:0045218 1/96 zonula adherens maintenance biological_process "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf] EOG8DZ47Z GO:0001738 1/96 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] EOG8DZ47Z GO:0008104 1/96 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8DZ47Z GO:0061541 1/96 rhabdomere morphogenesis biological_process "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [GOC:dph, PMID:22113834] EOG8DZ47Z GO:0007431 1/96 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8DZ47Z GO:0007424 1/96 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8DZ47Z GO:0032880 1/96 regulation of protein localization biological_process "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] EOG8DZ47Z GO:0005080 1/96 protein kinase C binding molecular_function "Interacting selectively and non-covalently with protein kinase C." [GOC:jl] EOG8DZ47Z GO:0035090 1/96 maintenance of apical/basal cell polarity biological_process "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf] EOG8DZ47Z GO:0035088 1/96 establishment or maintenance of apical/basal cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] EOG8DZ47Z GO:0008284 1/96 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG8DZ47Z GO:0030507 1/96 spectrin binding molecular_function "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] EOG8DZ47Z GO:0035239 1/96 tube morphogenesis biological_process "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] EOG8DZ47Z GO:0033157 1/96 regulation of intracellular protein transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] EOG8DZ47Z GO:0007043 1/96 cell-cell junction assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] EOG8DZ47Z GO:0016021 1/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DZ47Z GO:0016327 1/96 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG8DZ47Z GO:0045186 1/96 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG8DZ47Z GO:0046664 1/96 dorsal closure, amnioserosa morphology change biological_process "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] EOG8DZ47Z GO:0045198 1/96 establishment of epithelial cell apical/basal polarity biological_process "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] EOG8DZ47Z GO:0045197 1/96 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8DZ47Z GO:0004674 1/96 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8DZ47Z GO:0048477 1/96 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8DZ47Z GO:0034332 1/96 adherens junction organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah] EOG8DZ47Z GO:0005918 1/96 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8DZ47Z GO:0016028 1/96 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8DZ47Z GO:0050821 1/96 protein stabilization biological_process "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] EOG8DZ47Z GO:0042327 1/96 positive regulation of phosphorylation biological_process "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] EOG8DZ47Z GO:0007399 1/96 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8DZ47Z GO:0035002 1/96 liquid clearance, open tracheal system biological_process "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] EOG8DZ47Z GO:0061024 1/96 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8DZ47Z GO:0042052 1/96 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8DZ47Z GO:0046621 1/96 negative regulation of organ growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG8DZ47Z GO:0007435 1/96 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8DZ47Z GO:0016324 1/96 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8DZ47Z GO:0061336 1/96 cell morphogenesis involved in Malpighian tubule morphogenesis biological_process "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG8DZ47Z GO:0007443 1/96 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8DZ47Z GO:0051539 1/96 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8DZ47Z GO:0032435 1/96 negative regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] EOG8DZ47Z GO:0002009 1/96 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8DZ47Z GO:0001745 1/96 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG85F052 GO:0035091 9/66 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG85F052 GO:0034498 8/66 early endosome to Golgi transport biological_process "The directed movement of substances from early endosomes to the Golgi." [GOC:rb] EOG85F052 GO:0031901 8/66 early endosome membrane cellular_component "The lipid bilayer surrounding an early endosome." [GOC:pz] EOG85F052 GO:0006886 8/66 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG85F052 GO:0005509 2/66 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8N5ZB3 GO:0016758 34/108 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8N5ZB3 GO:0016999 1/108 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG8N5ZB3 GO:0004252 1/108 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8N5ZB3 GO:0015020 1/108 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG85F05P GO:0000166 81/311 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG85F05P GO:0003676 76/311 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85F05P GO:0003723 5/311 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG85F05P GO:0017148 3/311 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG85F05P GO:0003729 2/311 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG85F05P GO:0005515 1/311 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85F05P GO:0005634 1/311 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85F05P GO:0036099 1/311 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG85F05P GO:0043234 1/311 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG85F05P GO:0042803 1/311 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG85F05P GO:0048477 1/311 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG85F05P GO:0031536 1/311 positive regulation of exit from mitosis biological_process "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] EOG85F05P GO:0007319 1/311 negative regulation of oskar mRNA translation biological_process "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] EOG85F05P GO:0002121 1/311 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG85F05P GO:0046011 1/311 regulation of oskar mRNA translation biological_process "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] EOG85F05P GO:0043186 1/311 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG85F05P GO:0003730 1/311 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG85F05P GO:0007281 1/311 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG85F05P GO:0030727 1/311 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG85F05P GO:0005737 1/311 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85F05P GO:2000738 1/311 positive regulation of stem cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] EOG85F05P GO:0006378 1/311 mRNA polyadenylation biological_process "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] EOG85F05P GO:0007476 1/311 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG85F05P GO:0007286 1/311 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG85F05P GO:0042078 1/311 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG85F05P GO:0000381 1/311 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8N5ZD4 GO:0005524 3/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8N5ZD4 GO:0016020 2/11 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8N5ZD4 GO:0016021 2/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N5ZD4 GO:0042626 2/11 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8N5ZD4 GO:0015408 1/11 ferric-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] EOG8N5ZD4 GO:0005215 1/11 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8DZ49Z GO:0003676 6/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85F05F GO:0008289 41/142 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG85F05F GO:0005215 41/142 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG85F05F GO:0005875 1/142 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG85F05F GO:0007616 1/142 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8N5ZBJ GO:0035859 1/94 Seh1-associated complex cellular_component "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] EOG8N5ZBJ GO:0048813 1/94 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8N5ZBF GO:0006541 33/106 glutamine metabolic process biological_process "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] EOG8N5ZBF GO:0008242 32/106 omega peptidase activity molecular_function "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] EOG8N5ZBF GO:0034722 1/106 gamma-glutamyl-peptidase activity molecular_function "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] EOG8CJXXK GO:0003723 1/7 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CJXXK GO:0006355 1/7 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CJXXK GO:0004479 1/7 methionyl-tRNA formyltransferase activity molecular_function "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] EOG8CJXXK GO:0008168 1/7 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8CZDX2 GO:0008138 6/39 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8CZDX2 GO:0006470 6/39 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8WM77K GO:0004375 27/94 glycine dehydrogenase (decarboxylating) activity molecular_function "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] EOG8WM77K GO:0006546 27/94 glycine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] EOG8WM77K GO:0030170 26/94 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8WM77K GO:0016829 8/94 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8WM77K GO:0032440 2/94 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8WM77K GO:0003684 1/94 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8WM77K GO:0006281 1/94 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8WM77K GO:0003887 1/94 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG88KTTB GO:0016021 4/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88KTTB GO:0005615 2/84 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8WM77F GO:0048812 1/145 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8WM77F GO:0007156 1/145 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8WM77F GO:0005887 1/145 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WM77F GO:0042802 1/145 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8WM77W GO:0008270 7/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WM77W GO:0003676 2/106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WM77W GO:0010212 1/106 response to ionizing radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] EOG8WM77W GO:0006260 1/106 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8WM77W GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WM77W GO:0015074 1/106 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8WM77W GO:0033314 1/106 mitotic DNA replication checkpoint biological_process "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] EOG8WM77P GO:0004222 3/62 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WM77P GO:0008270 2/62 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WM77P GO:0005578 2/62 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8WM77P GO:0008233 1/62 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8WM77P GO:0031012 1/62 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8Q5C4Z GO:0008270 29/245 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Q5C4Z GO:0003676 26/245 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q5C4Z GO:0003964 4/245 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8Q5C4Z GO:0003723 4/245 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG81G5JG GO:0033596 1/88 TSC1-TSC2 complex cellular_component "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] EOG81G5JG GO:0007584 1/88 response to nutrient biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] EOG81G5JG GO:0032320 1/88 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG81G5JG GO:0005829 1/88 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG81G5JG GO:0019900 1/88 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG81G5JG GO:0032007 1/88 negative regulation of TOR signaling biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] EOG81G5JG GO:0045792 1/88 negative regulation of cell size biological_process "Any process that reduces cell size." [GOC:go_curators] EOG81G5JG GO:0030308 1/88 negative regulation of cell growth biological_process "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG81G5JG GO:0032956 1/88 regulation of actin cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] EOG81G5JG GO:0035069 1/88 larval midgut histolysis biological_process "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG81G5JG GO:0042325 1/88 regulation of phosphorylation biological_process "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] EOG81G5JG GO:0071456 1/88 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG81G5JG GO:0048640 1/88 negative regulation of developmental growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] EOG81G5JG GO:0060439 1/88 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG81G5JG GO:0051726 1/88 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG81G5JG GO:0005515 1/88 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81G5JG GO:0046620 1/88 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG81G5JG GO:0008340 1/88 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG81G5JG GO:0008285 1/88 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG81G5JG GO:2000377 1/88 regulation of reactive oxygen species metabolic process biological_process "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] EOG81G5JG GO:0035883 1/88 enteroendocrine cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] EOG81G5JG GO:0036335 1/88 intestinal stem cell homeostasis biological_process "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] EOG81G5JG GO:0019901 1/88 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG81G5JG GO:0001558 1/88 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG81G5JG GO:0038202 1/88 TORC1 signaling biological_process "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] EOG81G5JG GO:0048505 1/88 regulation of timing of cell differentiation biological_process "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] EOG81G5JG GO:0046627 1/88 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG81G5JG GO:0006629 1/88 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG81G5JG GO:0005737 1/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81G5JG GO:0046621 1/88 negative regulation of organ growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG81G5JG GO:0030695 1/88 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG81G5JG GO:0008286 1/88 insulin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] EOG81G5JG GO:0007165 1/88 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG81G5JG GO:0042127 1/88 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG85HVC8 GO:0046872 24/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG85HVC8 GO:0003676 22/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85HVC8 GO:0000166 1/62 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG85HVC8 GO:0005097 1/62 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG85HVC7 GO:0016021 35/156 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85HVC7 GO:0015171 35/156 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG85HVC7 GO:0003333 1/156 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8BP3RM GO:0046470 19/100 phosphatidylcholine metabolic process biological_process "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732] EOG8BP3RM GO:0004622 19/100 lysophospholipase activity molecular_function "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] EOG8BP3RM GO:0051402 11/100 neuron apoptotic process biological_process "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663] EOG8BP3RM GO:0005789 11/100 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8BP3RM GO:0007399 11/100 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8BP3RM GO:0034349 11/100 glial cell apoptotic process biological_process "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] EOG8BP3RM GO:0016021 11/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BP3RM GO:0061024 11/100 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8BP3RM GO:0006643 11/100 membrane lipid metabolic process biological_process "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] EOG8BP3RM GO:0006629 4/100 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8BP3RM GO:0007608 1/100 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8BP3RM GO:0008152 1/100 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8BP3RM GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85HVC3 GO:0005634 27/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85HVC3 GO:0006355 27/94 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85HVC3 GO:0007095 1/94 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG85HVC3 GO:0006402 1/94 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG85HVC3 GO:0006351 1/94 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG85HVC3 GO:0005515 1/94 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85HVC3 GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85HVC3 GO:0046331 1/94 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG85HVC3 GO:0031047 1/94 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG85HVC3 GO:0030014 1/94 CCR4-NOT complex cellular_component "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136] EOG85HVC3 GO:0017148 1/94 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8BP3RQ GO:0005524 26/105 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BP3RQ GO:0004822 26/105 isoleucine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063] EOG8BP3RQ GO:0002161 26/105 aminoacyl-tRNA editing activity molecular_function "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] EOG8BP3RQ GO:0006428 25/105 isoleucyl-tRNA aminoacylation biological_process "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8BP3RQ GO:0005737 25/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BP3RQ GO:0005975 1/105 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8BP3RQ GO:0006418 1/105 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG8BP3RQ GO:0004553 1/105 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8G4K4H GO:0046872 1/12 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8G4K4H GO:0004471 1/12 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] EOG8G4K4H GO:0008514 1/12 organic anion transmembrane transporter activity molecular_function "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] EOG8G4K4H GO:0051287 1/12 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8G4K4H GO:0016021 1/12 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81G5JV GO:0016020 2/5 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81G5JV GO:0009306 2/5 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG81G5JV GO:0006950 1/5 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG83XXK4 GO:0003676 5/25 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83XXK4 GO:0015074 4/25 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG83XXK4 GO:0003964 1/25 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG83XXK4 GO:0003723 1/25 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BP3RZ GO:0005524 28/93 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BP3RZ GO:0016887 27/93 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8BP3RZ GO:0015439 1/93 heme-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] EOG8R52GZ GO:0003677 27/96 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8R52GZ GO:0005664 27/96 nuclear origin of replication recognition complex cellular_component "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] EOG8R52GZ GO:0006260 27/96 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8R52GZ GO:0051297 1/96 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8R52GZ GO:0051298 1/96 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8R52GZ GO:0007611 1/96 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8R52GZ GO:0007612 1/96 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG8R52GZ GO:0006270 1/96 DNA replication initiation biological_process "The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] EOG8R52GZ GO:0030536 1/96 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8R52GZ GO:0007298 1/96 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8R52GZ GO:0072686 1/96 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8R52GZ GO:0008355 1/96 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8Q5C4D GO:0016787 28/88 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8Q5C4D GO:0046872 1/88 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VQD3V GO:0004252 1/77 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8R7XST GO:0016491 1/6 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG847J9D GO:0004674 1/7 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PG8FV GO:0006511 3/14 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8PG8FP GO:0005576 19/78 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PG8FP GO:0030414 18/78 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8PG8FP GO:0009897 1/78 external side of plasma membrane cellular_component "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] EOG8PG8FP GO:0009986 1/78 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8PG8FP GO:0005578 1/78 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8GB9MD GO:0006177 2/10 GMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] EOG8GB9MD GO:0005524 2/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GB9MD GO:0003922 2/10 GMP synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] EOG8GB9MD GO:0016462 2/10 pyrophosphatase activity molecular_function "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] EOG8ZPH92 GO:0004775 39/108 succinate-CoA ligase (ADP-forming) activity molecular_function "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] EOG8ZPH92 GO:0003878 39/108 ATP citrate synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163] EOG8ZPH92 GO:0048037 38/108 cofactor binding molecular_function "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] EOG8ZPH92 GO:0004776 4/108 succinate-CoA ligase (GDP-forming) activity molecular_function "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] EOG8ZPH92 GO:0006099 1/108 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8ZPH92 GO:0016020 1/108 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZPH92 GO:0005739 1/108 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8ZPH92 GO:0005525 1/108 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8ZPH92 GO:0046331 1/108 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8ZPH92 GO:0022008 1/108 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8VQD3C GO:0005524 8/44 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VQD3C GO:0003677 8/44 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VQD3C GO:0004386 7/44 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VQD3C GO:0016740 2/44 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8VQD3C GO:0008026 1/44 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8VQD3C GO:0006508 1/44 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8TF2ZZ GO:0005524 22/180 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF2ZZ GO:0004674 21/180 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8TF2ZZ GO:0004687 2/180 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8TF2ZZ GO:0008307 1/180 structural constituent of muscle molecular_function "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] EOG8TF2ZZ GO:0045214 1/180 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8TF2ZZ GO:0016020 1/180 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TF2ZZ GO:0004930 1/180 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8TF2ZZ GO:0006468 1/180 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8TF2ZZ GO:0016021 1/180 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TF2ZZ GO:0007156 1/180 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8TF2ZZ GO:0007498 1/180 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8TF2ZZ GO:0005509 1/180 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TF2ZZ GO:0030018 1/180 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8RV58H GO:0003723 2/31 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RV58H GO:0003964 2/31 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VQD37 GO:0042132 28/180 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] EOG8VQD37 GO:0005975 27/180 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8VQD37 GO:0006886 23/180 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8VQD37 GO:0016192 23/180 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8VQD37 GO:0008270 20/180 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VQD37 GO:0006727 1/180 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8VQD37 GO:0035556 1/180 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8VQD37 GO:0006487 1/180 protein N-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] EOG8VQD37 GO:0007041 1/180 lysosomal transport biological_process "The directed movement of substances into, out of or within a lysosome." [GOC:ai] EOG8VQD37 GO:0006897 1/180 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8VQD37 GO:0030897 1/180 HOPS complex cellular_component "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] EOG8VQD37 GO:0008340 1/180 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8VQD37 GO:0016020 1/180 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VQD37 GO:0007220 1/180 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8VQD37 GO:0035542 1/180 regulation of SNARE complex assembly biological_process "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] EOG8VQD37 GO:0033227 1/180 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8VQD37 GO:0003830 1/180 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] EOG8VQD37 GO:0046907 1/180 intracellular transport biological_process "The directed movement of substances within a cell." [GOC:ai] EOG8ZPH9G GO:0019901 1/73 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG8ZPH9G GO:0046872 1/73 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VQD38 GO:0016021 2/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VQD38 GO:0005509 1/9 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8F7R0W GO:0003677 9/22 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8F7R0W GO:0008094 8/22 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8F7R0W GO:0005524 8/22 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F7R0W GO:0007131 6/22 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8F7R0W GO:0005634 6/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F7R0W GO:0006281 5/22 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8F7R0W GO:0003908 1/22 methylated-DNA-[protein]-cysteine S-methyltransferase activity molecular_function "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] EOG8F7R0W GO:0006259 1/22 DNA metabolic process biological_process "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] EOG8F7R0W GO:0000166 1/22 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8F7R0V GO:0071632 1/94 optomotor response biological_process "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] EOG8F7R0V GO:0007630 1/94 jump response biological_process "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] EOG8F7R0V GO:0034551 1/94 mitochondrial respiratory chain complex III assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc] EOG8F7R0V GO:0016491 1/94 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F7R0V GO:0005739 1/94 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8F7R0V GO:0097033 1/94 mitochondrial respiratory chain complex III biogenesis biological_process "The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] EOG847J90 GO:0008270 4/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG847J91 GO:0008168 24/81 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8F7R0Q GO:0005524 21/46 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F7R0Q GO:0017111 18/46 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8F7R0Q GO:0016887 1/46 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8F7R0Q GO:0008568 1/46 microtubule-severing ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] EOG8ZPH9T GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPH9T GO:0006810 1/7 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8HHRHN GO:0018580 1/71 nitronate monooxygenase activity molecular_function "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770] EOG8XSP3N GO:0008061 250/966 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005576 250/966 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP3N GO:0006030 246/966 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0004252 27/966 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8XSP3N GO:0005044 26/966 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG8XSP3N GO:0016020 24/966 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XSP3N GO:0006032 4/966 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005975 4/966 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8XSP3N GO:0004568 4/966 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8XSP3N GO:0006955 2/966 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8XSP3N GO:0030247 2/966 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG8XSP3N GO:0030246 2/966 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8XSP3N GO:0006508 1/966 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8XSP3N GO:0007616 1/966 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8XSP3N GO:0004190 1/966 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8XSP3N GO:0007614 1/966 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8RJJFD GO:0016459 22/89 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8RJJFD GO:0003774 21/89 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8RJJFD GO:0005524 21/89 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RJJFD GO:0051015 1/89 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG8RJJFD GO:0042623 1/89 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8RJJFD GO:0030017 1/89 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8RJJFD GO:0006200 1/89 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8BGC8Z GO:0007186 14/75 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8BGC8Z GO:0019236 14/75 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG8Q5C41 GO:0005215 1/11 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8Q5C41 GO:0016020 1/11 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Q5C41 GO:0004872 1/11 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8RJJFN GO:0006396 13/93 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8RJJFN GO:0003723 13/93 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RJJFN GO:0003676 10/93 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RJJFS GO:0035556 11/71 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG83XXKX GO:0000166 1/92 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG83XXKX GO:0003676 1/92 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83XXKX GO:0007304 1/92 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG81G5J0 GO:0005524 23/96 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81G5J0 GO:0004674 18/96 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG81G5J0 GO:0017111 6/96 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG81G5J0 GO:0005634 5/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81G5J0 GO:0008270 5/96 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81G5J0 GO:0003700 5/96 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8JMB45 GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JMB45 GO:0008081 1/4 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG8JMB45 GO:0004814 1/4 arginine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] EOG8JMB45 GO:0006420 1/4 arginyl-tRNA aminoacylation biological_process "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8JMB45 GO:0046872 1/4 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C2KRH GO:0035556 2/14 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8C2KRH GO:0000155 2/14 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8C2KRH GO:0009190 2/14 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8C2KRH GO:0016849 2/14 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8R52HJ GO:0030246 155/416 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8R52HJ GO:0005615 3/416 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8R52HJ GO:0032504 3/416 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8R52HJ GO:0005534 3/416 galactose binding molecular_function "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732] EOG8R52HJ GO:0046692 2/416 sperm competition biological_process "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] EOG8R52HJ GO:0046008 2/416 regulation of female receptivity, post-mating biological_process "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] EOG8R52HJ GO:0008104 2/416 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8R52HJ GO:0008233 2/416 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8R52HJ GO:0016339 1/416 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG8R52HJ GO:0016787 1/416 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8R52HJ GO:0009986 1/416 cell surface cellular_component "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] EOG8R52HJ GO:0009166 1/416 nucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG8R52HJ GO:0016020 1/416 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8R52HJ GO:0005515 1/416 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8R52HJ GO:0005576 1/416 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8R52K3 GO:0008233 1/74 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8R52K3 GO:0042832 1/74 defense response to protozoan biological_process "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] EOG8R52K3 GO:0045087 1/74 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8R52K3 GO:0005576 1/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8R52K3 GO:0042742 1/74 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8C2KRT GO:0003993 96/479 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8C2KRT GO:0006909 1/479 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8NS5SV GO:0003676 23/121 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NS5SV GO:0008276 20/121 protein methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] EOG8NS5SV GO:0006886 8/121 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8NS5SV GO:0031083 8/121 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG8NS5SV GO:0008168 4/121 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8NS5SV GO:0005634 1/121 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NS5SV GO:0008270 1/121 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GF5VD GO:0003677 1/32 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81K1T1 GO:0008270 16/83 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GF5VH GO:0051056 22/88 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8GF5VH GO:0005096 22/88 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8GF5VH GO:0046582 1/88 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8GF5VH GO:0060293 1/88 germ plasm cellular_component "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph] EOG8GF5VH GO:0032861 1/88 activation of GTPase activity biological_process "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] EOG8GF5VH GO:0002121 1/88 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8GF5VJ GO:0003678 1/12 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8GF5VJ GO:0005524 1/12 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GF5VJ GO:0006260 1/12 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8WHC12 GO:0016020 16/63 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8WHC12 GO:0005509 15/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8WHC12 GO:0046692 1/63 sperm competition biological_process "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] EOG8WHC12 GO:0050982 1/63 detection of mechanical stimulus biological_process "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] EOG8WHC12 GO:0005262 1/63 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8WHC12 GO:0030317 1/63 sperm motility biological_process "Any process involved in the controlled movement of a sperm cell." [GOC:jl] EOG8WHC12 GO:0046693 1/63 sperm storage biological_process "The retention of sperm by a female following mating." [PMID:10885514] EOG8WHC12 GO:0070588 1/63 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8WHC12 GO:0006939 1/63 smooth muscle contraction biological_process "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] EOG8WHC12 GO:0007283 1/63 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8WHC12 GO:0030536 1/63 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8WHC14 GO:0005975 86/174 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WHC14 GO:0004568 85/174 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8WHC14 GO:0006032 84/174 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WHC14 GO:0005576 10/174 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8WHC14 GO:0007444 9/174 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8WHC14 GO:0008084 9/174 imaginal disc growth factor receptor binding molecular_function "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah] EOG8WHC14 GO:0007275 1/174 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8WHC14 GO:0006036 1/174 cuticle chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] EOG8WHC14 GO:0005615 1/174 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8WHC14 GO:0008061 1/174 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8WHC14 GO:0004553 1/174 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8GF5VP GO:0005737 1/6 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GF5VP GO:0004808 1/6 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] EOG8GF5VP GO:0016783 1/6 sulfurtransferase activity molecular_function "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] EOG8NS5SC GO:0016021 26/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5SC GO:0004989 26/93 octopamine receptor activity molecular_function "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai] EOG8NS5SC GO:0004715 3/93 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8NS5SC GO:0008227 1/93 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8NS5SC GO:0007211 1/93 octopamine or tyramine signaling pathway biological_process "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] EOG8NS5SC GO:0005887 1/93 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5SC GO:0005886 1/93 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NS5SC GO:1900738 1/93 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G-protein coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] EOG8NS5SC GO:0007608 1/93 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8NS5SC GO:0010578 1/93 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] EOG8NS5SK GO:0016021 21/70 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5SK GO:0006633 21/70 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8NS5SK GO:0016717 18/70 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG8NS5SK GO:0004768 3/70 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG8NS5SK GO:0005506 1/70 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8NS5SK GO:0005783 1/70 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8NS5S5 GO:0003676 19/46 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NS5S5 GO:0005515 1/46 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NS5S5 GO:0046872 1/46 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NS5S5 GO:0008270 1/46 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NS5S1 GO:0006012 38/146 galactose metabolic process biological_process "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] EOG8NS5S1 GO:0003978 38/146 UDP-glucose 4-epimerase activity molecular_function "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] EOG8NS5S1 GO:0050662 38/146 coenzyme binding molecular_function "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] EOG8NS5S1 GO:0044237 38/146 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8NS5S1 GO:0003974 1/146 UDP-N-acetylglucosamine 4-epimerase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] EOG880MB1 GO:0003677 1/142 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG880MB1 GO:0003678 1/142 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG880MB1 GO:0000723 1/142 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG880MB1 GO:0006281 1/142 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG880MB0 GO:0004601 35/114 peroxidase activity molecular_function "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] EOG880MB0 GO:0006979 35/114 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG880MB0 GO:0020037 35/114 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8NP9HG GO:0005524 12/81 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NP9HG GO:0003676 12/81 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NP9HG GO:0008026 12/81 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8NP9HG GO:0046872 2/81 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NP9HG GO:0031047 1/81 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8NP9HG GO:0031965 1/81 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG8NP9HG GO:0005694 1/81 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8NP9HG GO:0030154 1/81 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8NP9HG GO:0007275 1/81 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8NP9HG GO:0007283 1/81 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8NP9HG GO:0005829 1/81 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8NP9HG GO:0007126 1/81 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8NP9HG GO:0043186 1/81 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG84QWH7 GO:0005634 35/133 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84QWH7 GO:0003700 35/133 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG84QWH7 GO:0006351 34/133 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG84QWH7 GO:0044212 34/133 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG84QWH7 GO:0006915 33/133 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG84QWH7 GO:0006282 1/133 regulation of DNA repair biological_process "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] EOG84QWH7 GO:0010332 1/133 response to gamma radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] EOG84QWH7 GO:0008630 1/133 intrinsic apoptotic signaling pathway in response to DNA damage biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG84QWH7 GO:0007131 1/133 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG84QWH7 GO:1990248 1/133 regulation of transcription from RNA polymerase II promoter in response to DNA damage biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129] EOG84QWH7 GO:0010165 1/133 response to X-ray biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] EOG84QWH7 GO:0031571 1/133 mitotic G1 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG84QWH7 GO:0034644 1/133 cellular response to UV biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] EOG84QWH7 GO:0008134 1/133 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG84QWH7 GO:0045787 1/133 positive regulation of cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] EOG84QWH7 GO:0005667 1/133 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG84QWH7 GO:0042127 1/133 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG84QWH7 GO:0035234 1/133 ectopic germ cell programmed cell death biological_process "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] EOG84QWH7 GO:0009314 1/133 response to radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] EOG84QWH7 GO:2000685 1/133 positive regulation of cellular response to X-ray biological_process "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol] EOG84QWH7 GO:0030330 1/133 DNA damage response, signal transduction by p53 class mediator biological_process "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] EOG84QWH7 GO:0009411 1/133 response to UV biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] EOG84QWH7 GO:0048477 1/133 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG84QWH7 GO:0006978 1/133 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator biological_process "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] EOG84QWH7 GO:0002039 1/133 p53 binding molecular_function "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] EOG84QWH7 GO:0071480 1/133 cellular response to gamma radiation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] EOG84QWH7 GO:0042771 1/133 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG84QWH7 GO:0008219 1/133 cell death biological_process "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis] EOG84QWH7 GO:0045893 1/133 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84QWH7 GO:0005829 1/133 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84QWH7 GO:0003684 1/133 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG84QWH7 GO:0014016 1/133 neuroblast differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] EOG84QWH7 GO:0003690 1/133 double-stranded DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] EOG84QWH7 GO:0009267 1/133 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG84QWH7 GO:0006919 1/133 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG84QWH7 GO:0006974 1/133 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG84QWH7 GO:0010212 1/133 response to ionizing radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] EOG84QWH7 GO:0005515 1/133 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84QWH7 GO:0007405 1/133 neuroblast proliferation biological_process "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] EOG84QWH7 GO:0000122 1/133 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG84QWH7 GO:0046620 1/133 regulation of organ growth biological_process "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] EOG84QWH7 GO:0042246 1/133 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG84QWH7 GO:0008340 1/133 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG84QWH7 GO:0046533 1/133 negative regulation of photoreceptor cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] EOG84QWH7 GO:0003682 1/133 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG84QWH7 GO:0016239 1/133 positive regulation of macroautophagy biological_process "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] EOG84QWH7 GO:0043565 1/133 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG84QWH7 GO:0031625 1/133 ubiquitin protein ligase binding molecular_function "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] EOG84QWH7 GO:0043523 1/133 regulation of neuron apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG84QWH7 GO:0001047 1/133 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG84QWH7 GO:0000785 1/133 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG898XDK GO:0008270 1/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG898XDK GO:0008237 1/93 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8NP9HS GO:0016668 1/9 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8NP9HS GO:0004148 1/9 dihydrolipoyl dehydrogenase activity molecular_function "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] EOG8NP9HS GO:0045454 1/9 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8NP9HS GO:0050660 1/9 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8NP9HS GO:0016746 1/9 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG81K1TJ GO:0003896 4/35 DNA primase activity molecular_function "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] EOG8VT8F4 GO:0001895 1/60 retina homeostasis biological_process "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] EOG8VT8F4 GO:0007603 1/60 phototransduction, visible light biological_process "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8VT8F4 GO:0072321 1/60 chaperone-mediated protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773] EOG8VT8F4 GO:0090314 1/60 positive regulation of protein targeting to membrane biological_process "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] EOG8VT8F4 GO:0016063 1/60 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8VT8F4 GO:0071482 1/60 cellular response to light stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] EOG8VT8F4 GO:0097038 1/60 perinuclear endoplasmic reticulum cellular_component "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] EOG8NP9HV GO:0006188 2/8 IMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] EOG8NP9HV GO:0004018 2/8 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] EOG8NP9HV GO:0070626 1/8 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity molecular_function "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde] EOG886BTX GO:0016905 1/151 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG886BTX GO:0004550 1/151 nucleoside diphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] EOG886BTX GO:0006241 1/151 CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG886BTX GO:0006228 1/151 UTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] EOG886BTX GO:0006183 1/151 GTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] EOG886BTX GO:0005524 1/151 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG886BTX GO:0010506 1/151 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG80CKWR GO:0007264 55/204 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG80CKWR GO:0005085 53/204 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG80CKWR GO:0007417 2/204 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG80CKWR GO:0032863 2/204 activation of GTPase activity biological_process "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] EOG80CKWR GO:0005737 2/204 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80CKWR GO:0030036 1/204 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG80CKWR GO:0005089 1/204 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG80CKWR GO:0007391 1/204 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG80CKWR GO:0007523 1/204 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG80CKWR GO:0001726 1/204 ruffle cellular_component "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] EOG80CKWR GO:0035212 1/204 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG80CKWR GO:0007298 1/204 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG80CKWR GO:0030676 1/204 Rac guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG80CKWR GO:0016203 1/204 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG80CKWR GO:0045466 1/204 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG80CKWR GO:0007519 1/204 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG80CKWR GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80CKWR GO:0007010 1/204 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG80CKWR GO:0061327 1/204 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG80CKWR GO:0007520 1/204 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG80CKWR GO:0032314 1/204 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG80CKWR GO:0005886 1/204 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80CKWR GO:0000902 1/204 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG80CKWR GO:0019897 1/204 extrinsic component of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] EOG8WDGT2 GO:0004871 50/162 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8WDGT2 GO:0003924 50/162 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8WDGT2 GO:0005525 50/162 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8WDGT2 GO:0007188 48/162 adenylate cyclase-modulating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] EOG8WDGT2 GO:0007186 4/162 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8WDGT2 GO:0005515 2/162 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WDGT2 GO:0046872 2/162 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WDGT2 GO:0005834 2/162 heterotrimeric G-protein complex cellular_component "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] EOG8WDGT2 GO:0014045 2/162 establishment of endothelial blood-brain barrier biological_process "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] EOG8WDGT2 GO:0030866 2/162 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8WDGT2 GO:0019991 2/162 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8WDGT2 GO:0008356 2/162 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8WDGT2 GO:0032291 2/162 axon ensheathment in central nervous system biological_process "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] EOG8WDGT2 GO:0007419 2/162 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8WDGT2 GO:0031683 2/162 G-protein beta/gamma-subunit complex binding molecular_function "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] EOG8WDGT2 GO:0031234 2/162 extrinsic component of cytoplasmic side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] EOG8WDGT2 GO:0001664 2/162 G-protein coupled receptor binding molecular_function "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] EOG8WDGT2 GO:0060857 2/162 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG8WDGT2 GO:0045179 1/162 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8WDGT2 GO:0050916 1/162 sensory perception of sweet taste biological_process "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8WDGT2 GO:0005886 1/162 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WDGT2 GO:0001737 1/162 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8WDGT2 GO:0061343 1/162 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG8WDGT2 GO:0005938 1/162 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8WDGT2 GO:0045167 1/162 asymmetric protein localization involved in cell fate determination biological_process "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] EOG8WDGT2 GO:0051294 1/162 establishment of spindle orientation biological_process "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] EOG8WDGT2 GO:0007507 1/162 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8WDGT2 GO:0032880 1/162 regulation of protein localization biological_process "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] EOG8WDGT2 GO:0016055 1/162 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8WDGT2 GO:0055059 1/162 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8WDGT2 GO:0003677 1/162 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8WDGT2 GO:0042595 1/162 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8WDGT2 GO:0016324 1/162 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8WDGT2 GO:0045886 1/162 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8GF5WP GO:0030983 6/42 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8GF5WP GO:0006298 6/42 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8GF5WP GO:0005524 6/42 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WDGT9 GO:0004757 25/108 sepiapterin reductase activity molecular_function "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] EOG8WDGT9 GO:0006729 21/108 tetrahydrobiopterin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732] EOG8WDGT9 GO:0016491 4/108 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8WSZQQ GO:0008270 1/7 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FXTQW GO:0003676 4/9 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FXTQW GO:0046872 4/9 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WSZQW GO:0004197 24/35 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WSZQW GO:0006915 22/35 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8WSZQW GO:0012501 2/35 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8WSZQW GO:0005737 2/35 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZQW GO:0046672 1/35 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WSZQW GO:0006508 1/35 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8WSZQW GO:0035070 1/35 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8WSZQW GO:0045476 1/35 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8WSZQV GO:0030976 1/8 thiamine pyrophosphate binding molecular_function "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg] EOG8MGVPP GO:0005576 1/172 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8MGVPP GO:0006355 1/172 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8MGVPP GO:0043565 1/172 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8MGVPQ GO:0007165 22/80 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8MGVPQ GO:0042981 2/80 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8MGVPQ GO:0005737 2/80 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8MGVPQ GO:0050829 2/80 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8MGVPQ GO:0006915 2/80 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8MGVPQ GO:0061057 1/80 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG8MGVPQ GO:0005515 1/80 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8MGVPQ GO:0002230 1/80 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG8MGVPQ GO:0007291 1/80 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8MGVPQ GO:0045089 1/80 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8MGVPQ GO:0006919 1/80 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8MGVPQ GO:0006955 1/80 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8MGVPQ GO:0050700 1/80 CARD domain binding molecular_function "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] EOG8MGVPQ GO:0006963 1/80 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG8WSZQB GO:0016021 3/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WSZQB GO:0004721 2/137 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8WSZQB GO:0000166 1/137 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8WSZQB GO:0003676 1/137 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81NX3R GO:0003676 1/15 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MGVPJ GO:0003676 23/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MGVPJ GO:0004527 20/88 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8MGVPJ GO:0008859 1/88 exoribonuclease II activity molecular_function "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] EOG8WSZQF GO:0016192 29/102 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8WSZQF GO:0006886 29/102 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8WSZQF GO:0030131 26/102 clathrin adaptor complex cellular_component "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] EOG8WSZQF GO:0008565 23/102 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8WSZQF GO:0030117 3/102 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG8WSZQF GO:0030119 1/102 AP-type membrane coat adaptor complex cellular_component "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] EOG8WSZQF GO:0016183 1/102 synaptic vesicle coating biological_process "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709] EOG8WSZQF GO:0005886 1/102 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WSZQF GO:0005905 1/102 coated pit cellular_component "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] EOG8WSZQF GO:0030135 1/102 coated vesicle cellular_component "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] EOG8WSZQF GO:0048749 1/102 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8WSZQF GO:0006901 1/102 vesicle coating biological_process "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] EOG8WSZQF GO:0030136 1/102 clathrin-coated vesicle cellular_component "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] EOG8WSZQF GO:0005802 1/102 trans-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] EOG8WSZQF GO:0008021 1/102 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8WSZQF GO:0007269 1/102 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG844P1N GO:0042623 1/86 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG844P1N GO:0030286 1/86 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG844P1N GO:0003774 1/86 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG844P1N GO:0006200 1/86 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG844P1N GO:0007018 1/86 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8WSZQM GO:0016021 181/562 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WSZQM GO:0015116 160/562 sulfate transmembrane transporter activity molecular_function "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] EOG8WSZQM GO:0008271 20/562 secondary active sulfate transmembrane transporter activity molecular_function "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] EOG8WSZQM GO:0055085 1/562 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8WSZQM GO:0045434 1/562 negative regulation of female receptivity, post-mating biological_process "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] EOG8MGVPB GO:0030170 33/110 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8MGVPB GO:0006520 30/110 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8MGVPB GO:0016829 26/110 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8MGVPB GO:0004793 4/110 threonine aldolase activity molecular_function "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] EOG8MGVPB GO:0003824 3/110 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8MGVPC GO:0030170 24/94 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8MGVPC GO:0008453 23/94 alanine-glyoxylate transaminase activity molecular_function "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] EOG8MGVPC GO:0004760 22/94 serine-pyruvate transaminase activity molecular_function "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22855] EOG8MGVPC GO:0003824 1/94 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8MGVPC GO:0005811 1/94 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8MGVPC GO:0005777 1/94 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8MGVPC GO:0009436 1/94 glyoxylate catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] EOG82Z762 GO:0016021 1/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8T1M55 GO:0003824 1/8 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8RBSZH GO:0006355 1/87 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RBSZH GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81C9BH GO:0016811 23/88 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG81C9BH GO:0007611 1/88 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG81C9BH GO:0008355 1/88 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG89GNWT GO:0016779 1/11 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG89GNWT GO:0003924 1/11 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG89GNWT GO:0005525 1/11 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG89GNWT GO:0005622 1/11 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89GNWT GO:0003746 1/11 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8GJ245 GO:0005215 6/18 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8GJ245 GO:0016020 4/18 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8GJ245 GO:0008289 1/18 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8909RR GO:0007076 49/148 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8909RR GO:0000796 49/148 condensin complex cellular_component "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] EOG8909RR GO:0072587 1/148 DNA topoisomerase (ATP-hydrolyzing) activator activity molecular_function "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] EOG8909RR GO:0000793 1/148 condensed chromosome cellular_component "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] EOG8909RR GO:0007052 1/148 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8909RR GO:0002009 1/148 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8909RR GO:0022008 1/148 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8909RR GO:0000775 1/148 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8909RR GO:0051306 1/148 mitotic sister chromatid separation biological_process "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] EOG8909RR GO:0007443 1/148 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8909RR GO:0007424 1/148 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8909RR GO:0048567 1/148 ectodermal digestive tract morphogenesis biological_process "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] EOG8909RR GO:0000070 1/148 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8909RR GO:0008258 1/148 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8909RR GO:0006099 1/148 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8909RR GO:0000785 1/148 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8909RR GO:0007422 1/148 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8909RR GO:2000373 1/148 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity biological_process "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] EOG8STVM3 GO:0005634 19/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVM3 GO:0022008 1/83 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CRPD7 GO:0000228 22/94 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8CRPD7 GO:0005721 1/94 pericentric heterochromatin cellular_component "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] EOG8CRPD7 GO:0005705 1/94 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8CRPD7 GO:0007067 1/94 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8CRPD7 GO:0010628 1/94 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8CRPD7 GO:0000775 1/94 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8CRPD7 GO:0008278 1/94 cohesin complex cellular_component "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095] EOG8CRPD7 GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CRPD7 GO:0007052 1/94 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8CRPD7 GO:0016322 1/94 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8CRPD7 GO:0007064 1/94 mitotic sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] EOG8X6FP7 GO:0004842 31/107 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8X6FP7 GO:0071797 31/107 LUBAC complex cellular_component "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180] EOG8X6FP7 GO:0008270 27/107 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X6FP7 GO:0008474 1/107 palmitoyl-(protein) hydrolase activity molecular_function "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] EOG8X6FP4 GO:0005524 23/101 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FP4 GO:0007018 23/101 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8X6FP4 GO:0003777 23/101 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8X6FP4 GO:0005871 22/101 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8X6FP4 GO:0005874 21/101 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8X6FP4 GO:0000278 1/101 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8X6FP4 GO:0007067 1/101 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8X6FP4 GO:0007140 1/101 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8X6FP4 GO:0051233 1/101 spindle midzone cellular_component "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] EOG8X6FP4 GO:0005875 1/101 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8X6FP4 GO:0000922 1/101 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8X6FP4 GO:0000212 1/101 meiotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] EOG8X6FP4 GO:0040016 1/101 embryonic cleavage biological_process "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] EOG8X6FP4 GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8X6FP4 GO:0016321 1/101 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8X6FP4 GO:0007052 1/101 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8X6FP4 GO:0005876 1/101 spindle microtubule cellular_component "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] EOG8X6FP4 GO:0008152 1/101 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8X6FP4 GO:0051257 1/101 meiotic spindle midzone assembly biological_process "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb] EOG8CRPD3 GO:0003677 25/96 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CRPD3 GO:0006355 25/96 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CRPD3 GO:0005737 1/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CRPD3 GO:0009047 1/96 dosage compensation by hyperactivation of X chromosome biological_process "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] EOG8CRPD3 GO:0042714 1/96 dosage compensation complex assembly biological_process "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] EOG8CRPD3 GO:0003730 1/96 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8CRPD3 GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8CRPD3 GO:0017148 1/96 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8CRPD3 GO:0046331 1/96 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG89GNWH GO:0005201 51/200 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG89GNWH GO:0005581 49/200 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG89GNWH GO:0016787 2/200 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG89GNWH GO:0005587 2/200 collagen type IV trimer cellular_component "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] EOG89GNWH GO:0007519 1/200 skeletal muscle tissue development biological_process "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] EOG89GNWH GO:0000139 1/200 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG89GNWH GO:0007443 1/200 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG89GNWH GO:0061327 1/200 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG89GNWH GO:0035848 1/200 oviduct morphogenesis biological_process "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct] EOG89GNWH GO:0005351 1/200 sugar:proton symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] EOG89GNWH GO:0005811 1/200 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG89GNWH GO:0007391 1/200 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG89GNWH GO:0016021 1/200 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8909RK GO:0005549 1/26 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8MKR1R GO:0005634 1/7 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MKR1R GO:0033314 1/7 mitotic DNA replication checkpoint biological_process "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] EOG8MKR1R GO:0010212 1/7 response to ionizing radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] EOG8MKR1R GO:0006260 1/7 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG81C9BP GO:0003824 14/79 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8JQ6CJ GO:0006030 35/74 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8JQ6CJ GO:0008061 35/74 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8JQ6CJ GO:0005576 35/74 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87SVWT GO:0004383 1/9 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG87SVWT GO:0020037 1/9 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8CRPDB GO:0008241 7/22 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8CRPDB GO:0008237 7/22 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8CRPDB GO:0016020 7/22 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPDB GO:0004180 2/22 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG87SVWQ GO:0022900 1/3 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG87SVWQ GO:0009055 1/3 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG87SVWQ GO:0005886 1/3 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87SVWQ GO:0051536 1/3 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8909R7 GO:0005524 41/133 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8909R7 GO:0005737 27/133 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8909R7 GO:0006436 27/133 tryptophanyl-tRNA aminoacylation biological_process "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8909R7 GO:0004830 27/133 tryptophan-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] EOG8909R7 GO:0017111 3/133 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8909R7 GO:0003993 2/133 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8909R0 GO:0004332 1/12 fructose-bisphosphate aldolase activity molecular_function "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13] EOG8909R0 GO:0006096 1/12 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8909R0 GO:0008270 1/12 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ24K GO:0016021 4/39 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GJ24K GO:0005267 4/39 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG82Z76D GO:0005743 51/132 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG82Z76D GO:0006850 51/132 mitochondrial pyruvate transport biological_process "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai] EOG8CC6HX GO:0008061 3/19 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8CC6HX GO:0005576 3/19 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CC6HX GO:0006030 3/19 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8HX7JB GO:0008270 3/14 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HX7JB GO:0003676 2/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HX7JB GO:0003723 1/14 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HX7JB GO:0003964 1/14 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8X6FPX GO:0003824 177/787 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8X6FPX GO:0047077 20/787 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity molecular_function "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] EOG8X6FPX GO:0016874 19/787 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8X6FPX GO:0004497 7/787 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8X6FPX GO:0008756 4/787 o-succinylbenzoate-CoA ligase activity molecular_function "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] EOG8X6FPX GO:0004467 2/787 long-chain fatty acid-CoA ligase activity molecular_function "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3] EOG8X6FPX GO:0005524 2/787 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FPX GO:0006637 1/787 acyl-CoA metabolic process biological_process "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] EOG8X6FPX GO:0046627 1/787 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8X6FPX GO:0046949 1/787 fatty-acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] EOG8X6FPX GO:0005777 1/787 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8X6FPX GO:0019433 1/787 triglyceride catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] EOG8X6FPX GO:0001676 1/787 long-chain fatty acid metabolic process biological_process "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] EOG8X6FPX GO:0004321 1/787 fatty-acyl-CoA synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] EOG8X6FPX GO:0071616 1/787 acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] EOG8X6FPX GO:0016021 1/787 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X6FPX GO:0042626 1/787 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0009062 1/787 fatty acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] EOG8X6FPX GO:0016887 1/787 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0008218 1/787 bioluminescence biological_process "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] EOG81C9B2 GO:0052689 26/87 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG81C9B2 GO:0006482 26/87 protein demethylation biological_process "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] EOG81C9B2 GO:0005746 1/87 mitochondrial respiratory chain cellular_component "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] EOG81C9B2 GO:0046872 1/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81C9B2 GO:0004129 1/87 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8FXTQ2 GO:0015031 27/87 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8FXTQ2 GO:0000815 1/87 ESCRT III complex cellular_component "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] EOG8FXTQ2 GO:0000155 1/87 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8FXTQ2 GO:0016020 1/87 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG844P11 GO:0016021 119/447 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG844P11 GO:0030054 108/447 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG844P11 GO:0004889 108/447 acetylcholine-activated cation-selective channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] EOG844P11 GO:0045211 108/447 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG844P11 GO:0005230 10/447 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG844P11 GO:0006811 6/447 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG844P11 GO:0005892 5/447 acetylcholine-gated channel complex cellular_component "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462] EOG844P11 GO:0006812 5/447 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG844P11 GO:0007271 3/447 synaptic transmission, cholinergic biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine." [GOC:kmv, GOC:pr, Wikipedia:Cholinergic] EOG844P11 GO:0017085 2/447 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG844P11 GO:0007268 2/447 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG844P11 GO:0030431 1/447 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8FXTQ9 GO:0003677 343/539 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FXTQ9 GO:0000786 343/539 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8FXTQ9 GO:0005634 343/539 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FXTQ9 GO:0006334 343/539 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8FXTQ9 GO:0005811 111/539 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8FXTQ9 GO:0005515 23/539 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RBT42 GO:0080019 1/3 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8MGVP3 GO:0008270 14/476 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MGVP3 GO:0003676 4/476 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GJQ GO:0016788 21/72 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG883GJQ GO:0003723 19/72 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG883GJQ GO:0006139 17/72 nucleobase-containing compound metabolic process biological_process "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] EOG883GJQ GO:0003677 4/72 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG883GJQ GO:0006281 4/72 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG883GJQ GO:0003676 2/72 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GJQ GO:0004654 1/72 polyribonucleotide nucleotidyltransferase activity molecular_function "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] EOG8DZ48V GO:0003676 59/201 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DZ48V GO:0008270 5/201 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DZ48V GO:0016021 2/201 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88KTS1 GO:0009423 1/8 chorismate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] EOG88KTS1 GO:0004107 1/8 chorismate synthase activity molecular_function "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21023] EOG88KTS1 GO:0009073 1/8 aromatic amino acid family biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] EOG815JV1 GO:0009058 23/90 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG815JV1 GO:0016779 21/90 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG815JV1 GO:0004475 4/90 mannose-1-phosphate guanylyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232] EOG815JV1 GO:0005525 2/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG815JV1 GO:0009298 2/90 GDP-mannose biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] EOG815JV1 GO:0016740 1/90 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8DZ48X GO:0009073 3/18 aromatic amino acid family biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] EOG8DZ48X GO:0003849 3/18 3-deoxy-7-phosphoheptulonate synthase activity molecular_function "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720] EOG815JV5 GO:0008569 1/86 ATP-dependent microtubule motor activity, minus-end-directed molecular_function "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw] EOG815JV5 GO:0008152 1/86 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG815JV5 GO:0051493 1/86 regulation of cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] EOG815JV5 GO:0008407 1/86 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG815JV5 GO:0016325 1/86 oocyte microtubule cytoskeleton organization biological_process "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] EOG815JV5 GO:0007309 1/86 oocyte axis specification biological_process "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8DZ48D GO:0004842 26/110 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8DZ48D GO:0003723 24/110 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DZ48D GO:0008270 23/110 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DZ48D GO:0005634 1/110 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DZ48D GO:0045879 1/110 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8DZ48D GO:0007446 1/110 imaginal disc growth biological_process "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] EOG8DZ48D GO:0030162 1/110 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8DZ48D GO:0048749 1/110 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8DZ48D GO:0042787 1/110 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8DZ48D GO:0007112 1/110 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8DZ48D GO:0007444 1/110 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8DZ48D GO:0007283 1/110 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8DZ48D GO:0007289 1/110 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG8DZ48D GO:0008585 1/110 female gonad development biological_process "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] EOG8DZ48D GO:0005737 1/110 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DZ48D GO:0007455 1/110 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8DZ48B GO:0022008 1/106 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8DZ48N GO:0016740 24/88 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8DZ48N GO:0004314 3/88 [acyl-carrier-protein] S-malonyltransferase activity molecular_function "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] EOG8DZ48N GO:0005739 1/88 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8DZ48N GO:0006633 1/88 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8DZ48N GO:0008152 1/88 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8DZ48K GO:0051607 1/74 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8XH2D7 GO:0005262 6/44 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8XH2D7 GO:0016021 5/44 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2D7 GO:0042302 1/44 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8XH2D7 GO:0016020 1/44 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84J50V GO:0000166 19/95 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG84J50V GO:0003676 14/95 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84J50V GO:0071013 1/95 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG84J50V GO:0000398 1/95 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG84J50V GO:0005634 1/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84J50V GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG84J50V GO:0010506 1/95 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG84J50V GO:0005737 1/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84J50V GO:0006915 1/95 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG84J50V GO:0071011 1/95 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG82VC0D GO:0003676 9/46 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82VC0D GO:0008270 9/46 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82VC0D GO:0004190 2/46 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG82VC0D GO:0015074 1/46 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG82VC0D GO:0003723 1/46 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG82VC0D GO:0003964 1/46 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG82VC0D GO:0008234 1/46 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8JT2KP GO:0005694 1/5 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8JT2KP GO:0003677 1/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8JT2KP GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JT2KP GO:0003918 1/5 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] EOG8JT2KP GO:0006265 1/5 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG84J50Z GO:0006355 1/7 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84J50Z GO:0005634 1/7 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83V2D9 GO:0016491 1/3 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8X3KFX GO:0006030 12/15 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8X3KFX GO:0005576 12/15 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8X3KFX GO:0008061 12/15 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82RGN9 GO:0006464 37/94 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG82RGN9 GO:0004835 4/94 tubulin-tyrosine ligase activity molecular_function "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] EOG82RGN9 GO:0016874 1/94 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG85F06P GO:0016021 1/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z6529 GO:0005509 18/118 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8Z6529 GO:0005576 11/118 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z6529 GO:0030414 11/118 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8Z6529 GO:0051539 2/118 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8Z6529 GO:0008362 1/118 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8Z6529 GO:0007475 1/118 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG8Z6529 GO:0005201 1/118 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8Z6529 GO:0031012 1/118 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8Z6529 GO:0040005 1/118 chitin-based cuticle attachment to epithelium biological_process "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8Z6529 GO:0007424 1/118 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8Z6529 GO:0046331 1/118 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8Z0DNN GO:0003676 5/34 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85B3W6 GO:0016021 17/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85B3W6 GO:0005267 17/81 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG85B3W6 GO:0005524 1/81 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85B3W6 GO:0004674 1/81 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8WM783 GO:0008270 10/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WM783 GO:0003676 1/61 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82RGNW GO:0016811 1/110 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG82RGNT GO:0016740 1/73 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG82RGNT GO:0004597 1/73 peptide-aspartate beta-dioxygenase activity molecular_function "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] EOG82RGNZ GO:0016021 22/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82RGNZ GO:0055085 4/91 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG82RGNZ GO:0000139 1/91 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG82RGNZ GO:0005798 1/91 Golgi-associated vesicle cellular_component "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] EOG82RGNZ GO:0015783 1/91 GDP-fucose transport biological_process "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] EOG82RGNZ GO:0007625 1/91 grooming behavior biological_process "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] EOG82RGNZ GO:0005457 1/91 GDP-fucose transmembrane transporter activity molecular_function "Enables the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG82RGNZ GO:0036071 1/91 N-glycan fucosylation biological_process "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734] EOG82RGNZ GO:0036085 1/91 GDP-fucose import into Golgi lumen biological_process "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] EOG82RGNZ GO:0036066 1/91 protein O-linked fucosylation biological_process "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734] EOG82RGNZ GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82RGNZ GO:0008643 1/91 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG82RGNZ GO:0048193 1/91 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG82RGNZ GO:0005794 1/91 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8PVRCT GO:0005643 28/100 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8PVRCT GO:0006629 1/100 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8PVRCT GO:0007184 1/100 SMAD protein import into nucleus biological_process "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] EOG8PVRCT GO:0005737 1/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PVRCT GO:0051297 1/100 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8PVRCT GO:0006231 1/100 dTMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] EOG8PVRCT GO:0042332 1/100 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG8PVRCT GO:0004799 1/100 thymidylate synthase activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107] EOG8PVRCT GO:0022008 1/100 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG87WR57 GO:0016020 1/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85B3W8 GO:0004037 8/41 allantoicase activity molecular_function "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11019] EOG85B3W8 GO:0000256 8/41 allantoin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] EOG8H74TG GO:0003676 18/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H74TG GO:0046872 18/252 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H74TG GO:0016787 17/252 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8H74TG GO:0009405 1/252 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8H74TG GO:0004222 1/252 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8H74TG GO:0005604 1/252 basement membrane cellular_component "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] EOG8H74TG GO:0007155 1/252 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8H74TG GO:0003824 1/252 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8H74TG GO:0003677 1/252 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H74TG GO:0005509 1/252 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8H74TG GO:0005576 1/252 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8N5ZC1 GO:0003995 1/6 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8N5ZC1 GO:0050660 1/6 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8N5ZC3 GO:0003677 54/254 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N5ZC3 GO:0046872 35/254 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8N5ZC3 GO:0003676 10/254 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8N5ZC3 GO:0005634 4/254 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N5ZC3 GO:0005515 3/254 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8N5ZC3 GO:0005700 2/254 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8N5ZC3 GO:0003700 2/254 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8N5ZC3 GO:0007455 2/254 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8N5ZC3 GO:0006351 2/254 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8N5ZC3 GO:0003680 2/254 AT DNA binding molecular_function "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] EOG8N5ZC3 GO:0006355 2/254 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8N5ZC3 GO:0007478 2/254 leg disc morphogenesis biological_process "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] EOG8N5ZC3 GO:0045944 1/254 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8N5ZC3 GO:0043388 1/254 positive regulation of DNA binding biological_process "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] EOG8N5ZC3 GO:0030707 1/254 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8N5ZC3 GO:0007476 1/254 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8N5ZC3 GO:0001964 1/254 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8N5ZC3 GO:0048071 1/254 sex-specific pigmentation biological_process "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] EOG8N5ZC3 GO:0042682 1/254 regulation of compound eye cone cell fate specification biological_process "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] EOG8N5ZC3 GO:0007422 1/254 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8N5ZC3 GO:0061040 1/254 female gonad morphogenesis biological_process "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] EOG8N5ZC3 GO:0042675 1/254 compound eye cone cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] EOG8N5ZC3 GO:0008270 1/254 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N5ZC3 GO:0060446 1/254 branching involved in open tracheal system development biological_process "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] EOG8N5ZC3 GO:0046660 1/254 female sex differentiation biological_process "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] EOG8N5ZC3 GO:0002121 1/254 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8N5ZC3 GO:0031987 1/254 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8N5ZC3 GO:0048854 1/254 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8N5ZC3 GO:0000978 1/254 RNA polymerase II core promoter proximal region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] EOG8N5ZC3 GO:0001709 1/254 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG8N5ZC3 GO:0003682 1/254 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8N5ZC3 GO:0000122 1/254 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8N5ZC3 GO:0017053 1/254 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG8N5ZC3 GO:0048092 1/254 negative regulation of male pigmentation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] EOG8N5ZC3 GO:0048070 1/254 regulation of developmental pigmentation biological_process "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] EOG8N5ZC3 GO:0031208 1/254 POZ domain binding molecular_function "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] EOG8N5ZC3 GO:0035147 1/254 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG8N5ZC3 GO:0046843 1/254 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8N5ZC3 GO:0001078 1/254 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8N5ZC3 GO:0008360 1/254 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8N5ZC3 GO:0035001 1/254 dorsal trunk growth, open tracheal system biological_process "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] EOG8N5ZC3 GO:0007548 1/254 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG8N5ZC3 GO:0016476 1/254 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8N5ZC3 GO:0007298 1/254 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8N5ZC3 GO:0048750 1/254 compound eye corneal lens morphogenesis biological_process "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid] EOG8N5ZC3 GO:0045467 1/254 R7 cell development biological_process "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] EOG8N5ZC3 GO:0048666 1/254 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8N5ZC3 GO:0048053 1/254 R1/R6 development biological_process "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] EOG8N5ZC3 GO:0040003 1/254 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8N5ZC3 GO:0042803 1/254 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8N5ZC3 GO:0048086 1/254 negative regulation of developmental pigmentation biological_process "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] EOG8N5ZC3 GO:0000980 1/254 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG8N5ZC3 GO:0007426 1/254 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8N5ZC3 GO:0048813 1/254 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8N5ZC3 GO:0045892 1/254 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8N5ZC3 GO:0035151 1/254 regulation of tube size, open tracheal system biological_process "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] EOG8N5ZC6 GO:0008270 3/8 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N5ZC6 GO:0016491 2/8 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8N5ZC6 GO:0003960 1/8 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG8ZGRV1 GO:0005622 1/9 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8ZGRV1 GO:0043565 1/9 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8ZGRV1 GO:0003700 1/9 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8ZGRV1 GO:0016787 1/9 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZGRV6 GO:0003964 4/61 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8ZGRV6 GO:0004519 4/61 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8ZGRV6 GO:0008270 2/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VT8B0 GO:0046872 11/68 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VT8B0 GO:0003676 2/68 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VT8B0 GO:0008270 1/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8T7BHQ GO:0017148 1/93 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8T7BHQ GO:0030014 1/93 CCR4-NOT complex cellular_component "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136] EOG8T7BHQ GO:0006355 1/93 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8T7BHQ GO:0031047 1/93 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8T7BHQ GO:0005737 1/93 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T7BHQ GO:0006402 1/93 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG8T7BHQ GO:0006351 1/93 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8T7BHQ GO:0005634 1/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83V2B7 GO:0005634 2/4 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83V2B7 GO:0008270 2/4 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83V2B7 GO:0003676 2/4 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZPH8K GO:0016021 11/49 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZPH8K GO:0022857 9/49 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8ZPH8K GO:0022891 2/49 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8ZPH8K GO:0008643 1/49 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8F7R1H GO:0005525 2/20 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8F7R1H GO:0004871 2/20 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8F7R1H GO:0003924 2/20 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8F7R1H GO:0007186 2/20 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8BCH28 GO:0005680 2/188 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG8BCH28 GO:0030163 2/188 protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] EOG8BCH28 GO:0005819 2/188 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8BCH28 GO:0045842 2/188 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8BCH28 GO:0031145 2/188 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083] EOG8BCH28 GO:0004402 2/188 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8BCH28 GO:0005813 2/188 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8BCH28 GO:0008054 2/188 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8BCH28 GO:0090302 2/188 APC-Cdc20 complex activity molecular_function "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] EOG8BCH28 GO:0005737 2/188 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8BCH28 GO:0007144 1/188 female meiosis I biological_process "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] EOG8BCH28 GO:0010001 1/188 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8BCH28 GO:0030162 1/188 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8BCH28 GO:0030424 1/188 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8BCH28 GO:0008347 1/188 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8BCH28 GO:0005814 1/188 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG8BCH28 GO:0006470 1/188 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8BCH28 GO:0009987 1/188 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8BCH28 GO:0046872 1/188 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BCH28 GO:0022008 1/188 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8BCH28 GO:0007096 1/188 regulation of exit from mitosis biological_process "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] EOG8BCH28 GO:0006909 1/188 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8BCH28 GO:0031536 1/188 positive regulation of exit from mitosis biological_process "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] EOG8BCH28 GO:0004722 1/188 protein serine/threonine phosphatase activity molecular_function "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] EOG8BCH28 GO:0007147 1/188 female meiosis II biological_process "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] EOG8BCH28 GO:0007067 1/188 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8BCH28 GO:0000278 1/188 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8BCH28 GO:0000776 1/188 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG8BCH28 GO:0030718 1/188 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8BCH28 GO:0007088 1/188 regulation of mitotic nuclear division biological_process "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8BCH28 GO:0007455 1/188 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8BCH28 GO:0051301 1/188 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8BCH28 GO:0001745 1/188 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8T7BHN GO:0004767 45/153 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8T7BHN GO:0006685 45/153 sphingomyelin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] EOG8T7BHN GO:0016787 2/153 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BCH22 GO:0016758 383/1077 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8BCH22 GO:0030259 14/1077 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG8BCH22 GO:0015020 13/1077 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG8BCH22 GO:0030246 12/1077 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BCH22 GO:0016999 11/1077 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG8BCH22 GO:0016740 3/1077 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8BCH22 GO:0004181 1/1077 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG8BCH22 GO:0008168 1/1077 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8BCH22 GO:0003851 1/1077 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] EOG8BCH22 GO:0008270 1/1077 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BCH22 GO:0003676 1/1077 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BCH22 GO:0002121 1/1077 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8MPM83 GO:0006281 1/3 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8MPM83 GO:0003678 1/3 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8MPM83 GO:0000723 1/3 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8MPM83 GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BCH25 GO:0005524 41/124 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BCH25 GO:0016021 35/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BCH25 GO:0004713 23/124 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8BCH25 GO:0005007 19/124 fibroblast growth factor-activated receptor activity molecular_function "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] EOG8BCH25 GO:0008284 16/124 positive regulation of cell proliferation biological_process "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] EOG8BCH25 GO:0060173 4/124 limb development biological_process "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] EOG8BCH25 GO:0008543 2/124 fibroblast growth factor receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] EOG8BCH25 GO:0008347 2/124 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8BCH25 GO:0006468 2/124 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8BCH25 GO:0018108 2/124 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8BCH25 GO:0004714 1/124 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8BCH25 GO:0001763 1/124 morphogenesis of a branching structure biological_process "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] EOG8BCH25 GO:0007428 1/124 primary branching, open tracheal system biological_process "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8BCH25 GO:0050829 1/124 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8BCH25 GO:0007429 1/124 secondary branching, open tracheal system biological_process "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8BCH25 GO:0048542 1/124 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8BCH25 GO:0007426 1/124 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8BCH25 GO:0007419 1/124 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8BCH25 GO:0007493 1/124 endodermal cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] EOG8BCH25 GO:0048747 1/124 muscle fiber development biological_process "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] EOG8BCH25 GO:0008360 1/124 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8BCH25 GO:0008354 1/124 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8BCH25 GO:0030517 1/124 negative regulation of axon extension biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] EOG8BCH25 GO:0000187 1/124 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG8BCH25 GO:0007522 1/124 visceral muscle development biological_process "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] EOG8BCH25 GO:0046847 1/124 filopodium assembly biological_process "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] EOG8BCH25 GO:0007435 1/124 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8BCH25 GO:0008406 1/124 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8BCH25 GO:0010002 1/124 cardioblast differentiation biological_process "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8BCH25 GO:0007298 1/124 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8BCH25 GO:0007430 1/124 terminal branching, open tracheal system biological_process "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG8BCH25 GO:0007506 1/124 gonadal mesoderm development biological_process "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] EOG8BCH25 GO:0007280 1/124 pole cell migration biological_process "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] EOG8BCH25 GO:0060446 1/124 branching involved in open tracheal system development biological_process "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] EOG8BCH25 GO:0005886 1/124 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8BCH25 GO:0060439 1/124 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG8BCH25 GO:0007427 1/124 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8BCH25 GO:0035153 1/124 epithelial cell type specification, open tracheal system biological_process "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] EOG8BCH25 GO:0010001 1/124 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8BCH25 GO:0007509 1/124 mesoderm migration involved in gastrulation biological_process "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] EOG8BCH25 GO:0005515 1/124 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8BCH25 GO:0007369 1/124 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8BCH25 GO:0061320 1/124 pericardial nephrocyte differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] EOG8BCH25 GO:0016477 1/124 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8BCH25 GO:0035215 1/124 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8BCH25 GO:0060438 1/124 trachea development biological_process "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG8BCH25 GO:0007507 1/124 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8BCH25 GO:0045089 1/124 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8BCH25 GO:0007500 1/124 mesodermal cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] EOG8BCH25 GO:0007431 1/124 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8BCH25 GO:0007424 1/124 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8BCH25 GO:0007525 1/124 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8BCH25 GO:0008078 1/124 mesodermal cell migration biological_process "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] EOG8BCH25 GO:0001710 1/124 mesodermal cell fate commitment biological_process "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] EOG8BCH25 GO:0007523 1/124 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG8BCH25 GO:0007417 1/124 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG88D389 GO:0007165 19/141 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG88D389 GO:0007432 1/141 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG88D389 GO:0008347 1/141 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG88D389 GO:0050919 1/141 negative chemotaxis biological_process "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] EOG88D389 GO:0008045 1/141 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG88D389 GO:0007411 1/141 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG88D389 GO:0005515 1/141 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88D389 GO:0005043 1/141 netrin receptor activity involved in chemorepulsion molecular_function "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling] EOG88D389 GO:0016021 1/141 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SFCN1 GO:0009089 5/16 lysine biosynthetic process via diaminopimelate biological_process "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] EOG8SFCN1 GO:0008840 3/16 4-hydroxy-tetrahydrodipicolinate synthase molecular_function "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14848] EOG8SFCN1 GO:0008839 1/16 4-hydroxy-tetrahydrodipicolinate reductase molecular_function "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8] EOG8SFCN1 GO:0005524 1/16 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SFCN1 GO:0016887 1/16 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8SFCN1 GO:0047200 1/16 tetrahydrodipicolinate N-acetyltransferase activity molecular_function "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13088] EOG8SFCN1 GO:0005737 1/16 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SFCN1 GO:0003942 1/16 N-acetyl-gamma-glutamyl-phosphate reductase activity molecular_function "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] EOG8SFCN1 GO:0051287 1/16 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8SFCN1 GO:0016829 1/16 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG89S8N4 GO:0016021 26/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89S8N4 GO:0007275 25/95 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG89S8N4 GO:0001738 1/95 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] EOG89S8N4 GO:0005515 1/95 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89S8N4 GO:0007298 1/95 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG89S8N4 GO:0070593 1/95 dendrite self-avoidance biological_process "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] EOG89S8N4 GO:0001736 1/95 establishment of planar polarity biological_process "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] EOG89S8N4 GO:0005109 1/95 frizzled binding molecular_function "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315] EOG89S8N4 GO:0005886 1/95 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89S8N4 GO:0042067 1/95 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG89S8N4 GO:0090175 1/95 regulation of establishment of planar polarity biological_process "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8TMTM1 GO:0004568 1/3 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8TMTM1 GO:0006032 1/3 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8TMTM1 GO:0005975 1/3 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG88D386 GO:0016021 1/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88D386 GO:0005524 1/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88D386 GO:0042626 1/91 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8V19DR GO:0004222 23/91 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8V19DR GO:0008270 21/91 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8V19DR GO:0008237 1/91 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8V19DR GO:0006509 1/91 membrane protein ectodomain proteolysis biological_process "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] EOG8V19DR GO:0016021 1/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V19DS GO:0005622 20/111 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8V19DS GO:0008270 11/111 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8V19DS GO:0007409 1/111 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8V19DS GO:0016199 1/111 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8V19DS GO:0007411 1/111 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8V19DS GO:0038007 1/111 netrin-activated signaling pathway biological_process "A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323] EOG8V19DS GO:0022008 1/111 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8V19DQ GO:0006915 11/80 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8V19DQ GO:0003676 10/80 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V19DQ GO:0005509 1/80 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8V19DQ GO:0051301 1/80 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG88SK8M GO:0009420 1/10 bacterial-type flagellum filament cellular_component "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] EOG88SK8M GO:0005198 1/10 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG88SK8M GO:0001539 1/10 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG8GXJ1X GO:0055085 12/42 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8GXJ1X GO:0016021 12/42 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SFCNS GO:0016846 1/4 carbon-sulfur lyase activity molecular_function "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-] EOG88D38Z GO:0006421 25/95 asparaginyl-tRNA aminoacylation biological_process "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG88D38Z GO:0005524 25/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88D38Z GO:0005737 25/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88D38Z GO:0004816 25/95 asparagine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183] EOG88D38Z GO:0003676 23/95 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88D38Z GO:0016774 2/95 phosphotransferase activity, carboxyl group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] EOG88D38Z GO:0016301 2/95 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG88D38Z GO:0004815 1/95 aspartate-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] EOG89S8NZ GO:0031409 1/89 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG89S8NZ GO:0007476 1/89 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG89S8NZ GO:0005576 1/89 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88SK85 GO:0006596 40/182 polyamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] EOG88SK85 GO:0003824 34/182 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG88SK85 GO:0004586 10/182 ornithine decarboxylase activity molecular_function "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22967] EOG88SK85 GO:0033387 2/182 putrescine biosynthetic process from ornithine biological_process "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] EOG88SK85 GO:0009089 1/182 lysine biosynthetic process via diaminopimelate biological_process "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] EOG88SK85 GO:0008836 1/182 diaminopimelate decarboxylase activity molecular_function "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15104] EOG88D38H GO:0003723 20/98 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG88D38H GO:0045494 1/98 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG88D38H GO:0007474 1/98 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG89S8NK GO:0016717 19/93 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG89S8NK GO:0006633 12/93 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG89S8NK GO:0016021 12/93 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89S8NK GO:0004768 3/93 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG89S8NK GO:0005506 1/93 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG89S8NK GO:0005783 1/93 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8BCH2N GO:0016021 43/114 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BCH2N GO:0070290 1/114 N-acylphosphatidylethanolamine-specific phospholipase D activity molecular_function "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693] EOG8BCH2N GO:0008270 1/114 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BCH2M GO:0003977 1/9 UDP-N-acetylglucosamine diphosphorylase activity molecular_function "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13512] EOG8BCH2M GO:0019134 1/9 glucosamine-1-phosphate N-acetyltransferase activity molecular_function "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13728] EOG8BCH2M GO:0000287 1/9 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8BCH2M GO:0009252 1/9 peptidoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8BCH2M GO:0000902 1/9 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8BCH2M GO:0009103 1/9 lipopolysaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] EOG8BCH2M GO:0005737 1/9 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8F7R12 GO:0004970 18/72 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8F7R12 GO:0016020 18/72 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8F7R12 GO:0005234 18/72 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8F7R12 GO:0005634 1/72 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F7R12 GO:0008270 1/72 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8F7R16 GO:0022904 3/48 respiratory electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] EOG8F7R16 GO:0009055 3/48 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8F7R16 GO:0016491 3/48 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F7R16 GO:0016020 2/48 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8F7R16 GO:0016021 1/48 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F7R16 GO:0007283 1/48 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8F7R16 GO:0005743 1/48 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8F7R16 GO:0070469 1/48 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8F7R16 GO:0046872 1/48 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8THZ8P GO:0003755 1/6 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8THZ8P GO:0006457 1/6 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8ZPH80 GO:0046907 26/111 intracellular transport biological_process "The directed movement of substances within a cell." [GOC:ai] EOG8ZPH80 GO:0008270 24/111 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZPH80 GO:0005875 1/111 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8ZPH80 GO:0006607 1/111 NLS-bearing protein import into nucleus biological_process "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] EOG8ZPH80 GO:0007184 1/111 SMAD protein import into nucleus biological_process "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] EOG8ZPH80 GO:0005811 1/111 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8ZPH80 GO:0006606 1/111 protein import into nucleus biological_process "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] EOG8V71Z9 GO:0008270 3/20 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZPH89 GO:0016021 4/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZPH89 GO:0004930 4/8 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8ZPH89 GO:0005886 2/8 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8ZPH89 GO:0007218 2/8 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8ZPH89 GO:0030246 2/8 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG879HQP GO:0006364 1/5 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG879HQP GO:0004222 1/5 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8D81N2 GO:0005525 25/86 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8D81N2 GO:0006184 25/86 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8D81N2 GO:0007264 25/86 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8D81N2 GO:0016020 25/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8D81N2 GO:0004767 2/86 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8D81N5 GO:0008061 2/20 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8D81N5 GO:0005576 2/20 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8D81N5 GO:0006030 2/20 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG873S5V GO:0000175 1/4 3'-5'-exoribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] EOG873S5V GO:0003723 1/4 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG873S5V GO:0046872 1/4 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG873S5V GO:0006396 1/4 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG873S5V GO:0004654 1/4 polyribonucleotide nucleotidyltransferase activity molecular_function "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] EOG873S5V GO:0006402 1/4 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG88WFFS GO:0003735 1/49 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG88WFFS GO:0015934 1/49 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG88WFFS GO:0035091 1/49 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG88WFFS GO:0006412 1/49 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8V45PH GO:0004632 3/91 phosphopantothenate--cysteine ligase activity molecular_function "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] EOG8V45PH GO:0022416 1/91 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8V45PH GO:0007303 1/91 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8V45PH GO:0007297 1/91 ovarian follicle cell migration biological_process "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8V45PH GO:0070328 1/91 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8V45PH GO:0030036 1/91 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8V45PH GO:0030708 1/91 germarium-derived female germ-line cyst encapsulation biological_process "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] EOG8V45PH GO:0030713 1/91 ovarian follicle cell stalk formation biological_process "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8V45PH GO:0007476 1/91 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8V45PH GO:0055091 1/91 phospholipid homeostasis biological_process "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl] EOG8V45PH GO:0015937 1/91 coenzyme A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] EOG8V45PH GO:0046843 1/91 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG873S5K GO:0016021 1/27 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG873S5K GO:0007219 1/27 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG873S5K GO:0045746 1/27 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG873S5K GO:0007423 1/27 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG873S5K GO:0005515 1/27 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG873S5K GO:0030863 1/27 cortical cytoskeleton cellular_component "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] EOG873S5K GO:0008356 1/27 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG873S5K GO:0005737 1/27 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG873S5K GO:0005769 1/27 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG873S5K GO:0005112 1/27 Notch binding molecular_function "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] EOG873S5K GO:0005886 1/27 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG873S5K GO:0045035 1/27 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG873S5K GO:0003007 1/27 heart morphogenesis biological_process "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] EOG873S5K GO:0007422 1/27 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG873S5K GO:0005770 1/27 late endosome cellular_component "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] EOG88WFFT GO:0048015 30/109 phosphatidylinositol-mediated signaling biological_process "A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG88WFFT GO:0046854 26/109 phosphatidylinositol phosphorylation biological_process "The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732] EOG88WFFT GO:0016773 22/109 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG88WFFT GO:0016301 21/109 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG88WFFT GO:0004430 4/109 1-phosphatidylinositol 4-kinase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880] EOG88WFFT GO:0004797 1/109 thymidine kinase activity molecular_function "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] EOG88WFFT GO:0005524 1/109 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88WFFT GO:0005886 1/109 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8W9MJJ GO:0016410 1/4 N-acyltransferase activity molecular_function "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8W9MJJ GO:0042158 1/4 lipoprotein biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732] EOG8W9MJJ GO:0005524 1/4 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8W9MJJ GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M67ZM GO:0000156 4/21 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8M67ZM GO:0003677 2/21 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8M67ZM GO:0006355 2/21 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8M67ZM GO:0016021 1/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M67ZM GO:0016301 1/21 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8M67ZM GO:0000155 1/21 phosphorelay sensor kinase activity molecular_function "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] EOG8M67ZM GO:0046872 1/21 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M67ZM GO:0005524 1/21 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M67ZH GO:0016021 51/185 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M67ZH GO:0004946 35/185 bombesin receptor activity molecular_function "Combining with bombesin to initiate a change in cell activity." [GOC:ai] EOG8M67ZH GO:0004930 12/185 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8M67ZH GO:0004983 4/185 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8M67ZH GO:0007186 2/185 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8M67ZH GO:0008188 2/185 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8M67ZH GO:0050254 2/185 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8M67ZH GO:0007218 2/185 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8M67ZH GO:0005887 1/185 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M67ZH GO:0004252 1/185 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8M67ZH GO:0008261 1/185 allatostatin receptor activity molecular_function "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] EOG8G4K78 GO:0016787 1/101 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8G4K78 GO:0005615 1/101 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8M67ZB GO:0030414 21/115 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8M67ZB GO:0005576 21/115 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8M67ZB GO:0016787 2/115 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8M67ZB GO:0016020 1/115 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M67ZB GO:0004930 1/115 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG81G5K4 GO:0003700 50/159 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81G5K4 GO:0005634 43/159 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81G5K4 GO:0043565 31/159 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG81G5K4 GO:0000976 19/159 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG81G5K4 GO:0007275 2/159 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81G5K4 GO:0007480 1/159 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG81G5K4 GO:0021782 1/159 glial cell development biological_process "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG81G5K4 GO:0048800 1/159 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG81G5K4 GO:0045944 1/159 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG81G5K4 GO:0035015 1/159 elongation of arista core biological_process "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] EOG81G5K4 GO:0005737 1/159 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81G5K4 GO:0045747 1/159 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG81G5K4 GO:0035218 1/159 leg disc development biological_process "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] EOG81G5K4 GO:0000977 1/159 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG81G5K4 GO:0007399 1/159 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG81G5K4 GO:0007422 1/159 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG81G5K4 GO:0010628 1/159 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG81G5K4 GO:0022416 1/159 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG81G5K4 GO:0045892 1/159 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG81G5K4 GO:0005515 1/159 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81G5K4 GO:0043234 1/159 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG81G5K4 GO:0010001 1/159 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG81G5K4 GO:0001077 1/159 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG81G5K3 GO:0030170 36/119 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81G5K3 GO:0009058 35/119 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG81G5K3 GO:0003824 24/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81G5K3 GO:0008483 6/119 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG81G5K3 GO:0004021 6/119 L-alanine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456] EOG8JWXTW GO:0005737 29/114 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JWXTW GO:0005524 26/114 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JWXTW GO:0004821 22/114 histidine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] EOG8JWXTW GO:0006427 21/114 histidyl-tRNA aminoacylation biological_process "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8JWXTW GO:0006418 6/114 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG8JWXTW GO:0004812 5/114 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8V19G8 GO:0048060 1/82 negative gravitaxis biological_process "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] EOG8V19G8 GO:0070286 1/82 axonemal dynein complex assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621] EOG8V19G8 GO:0035253 1/82 ciliary rootlet cellular_component "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867] EOG8V19G8 GO:0031514 1/82 motile cilium cellular_component "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8V19G8 GO:0003341 1/82 cilium movement biological_process "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] EOG8V19G8 GO:0044297 1/82 cell body cellular_component "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] EOG8V19G8 GO:0097542 1/82 ciliary tip cellular_component "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417] EOG8R52HP GO:0006810 1/94 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8R52HP GO:0005794 1/94 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8M0HJM GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M0HJM GO:0051205 1/4 protein insertion into membrane biological_process "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai] EOG8PP0XS GO:0003755 1/76 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8PP0XS GO:0004221 1/76 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG8PP0XS GO:0006457 1/76 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8R269Q GO:0005524 1/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R269Q GO:0006298 1/9 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8R269Q GO:0030983 1/9 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8BP3SN GO:0030246 2/5 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BP3SN GO:0005975 2/5 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8BP3SN GO:0004553 2/5 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8JMB5D GO:0006777 13/22 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG8HHRGK GO:0004252 17/78 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8HHRGK GO:0016787 2/78 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8HHRGK GO:0048803 1/78 imaginal disc-derived male genitalia morphogenesis biological_process "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] EOG8HHRGK GO:0005615 1/78 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8HHRGK GO:0006508 1/78 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8G4K7K GO:0005230 1/4 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8G4K7K GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80KBCM GO:0035556 30/108 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG80KBCM GO:0004435 25/108 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG80KBCM GO:0004871 24/108 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG80KBCM GO:0005509 20/108 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG80KBCM GO:0006629 18/108 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG80KBCM GO:0009395 11/108 phospholipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG80KBCM GO:0008081 4/108 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG80KBCM GO:0030307 1/108 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG80KBCM GO:0007298 1/108 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG80KBCM GO:0032868 1/108 response to insulin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] EOG80KBCM GO:0032065 1/108 cortical protein anchoring biological_process "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] EOG80KBCM GO:0005938 1/108 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG80KBCM GO:0045596 1/108 negative regulation of cell differentiation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] EOG80KBCM GO:0042059 1/108 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG80KBCM GO:0005543 1/108 phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG81G5KX GO:0003676 2/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8C5G13 GO:0031409 6/54 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8C5G13 GO:0009267 1/54 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8C5G13 GO:0034599 1/54 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG8C5G13 GO:0005576 1/54 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8C5G13 GO:0005615 1/54 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8C5G13 GO:0036094 1/54 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG8C5G13 GO:0008340 1/54 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8V45P8 GO:0016021 94/315 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V45P8 GO:0015171 94/315 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8V45P8 GO:0003333 2/315 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8V45P8 GO:0060356 2/315 leucine import biological_process "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] EOG8V45P8 GO:0006865 1/315 amino acid transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8V45P8 GO:0008049 1/315 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8V45P8 GO:0007619 1/315 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8V45P8 GO:0015813 1/315 L-glutamate transport biological_process "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb] EOG8V45P8 GO:0015734 1/315 taurine transport biological_process "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8V45P8 GO:0007635 1/315 chemosensory behavior biological_process "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] EOG8V45P8 GO:0050832 1/315 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8V45P8 GO:0006868 1/315 glutamine transport biological_process "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8V45P8 GO:0014047 1/315 glutamate secretion biological_process "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] EOG8V45P8 GO:0031594 1/315 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8D81NS GO:0016021 2/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D81NS GO:0004983 2/3 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8W9MJ5 GO:0008168 35/123 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8W9MJ5 GO:0008276 5/123 protein methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] EOG8W9MJ5 GO:0005737 5/123 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W9MJ5 GO:0017069 1/123 snRNA binding molecular_function "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah] EOG8W9MJ5 GO:0032259 1/123 methylation biological_process "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] EOG8W9MJ5 GO:0032502 1/123 developmental process biological_process "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] EOG8W9MJ5 GO:0017148 1/123 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG8W9MJ5 GO:0022008 1/123 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8W9MJ5 GO:0001085 1/123 RNA polymerase II transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] EOG8W9MJ5 GO:0005515 1/123 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W9MJ5 GO:0042048 1/123 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8W9MJ5 GO:0008176 1/123 tRNA (guanine-N7-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] EOG8HB14X GO:0016020 2/4 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HB14X GO:0055085 2/4 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG873S52 GO:0050660 110/344 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG873S52 GO:0009055 107/344 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG873S52 GO:0051537 105/344 2 iron, 2 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG873S52 GO:0016614 104/344 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG873S52 GO:0005506 90/344 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG873S52 GO:0046872 23/344 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG873S52 GO:0016491 9/344 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG873S52 GO:0008762 6/344 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG873S52 GO:0051536 2/344 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG873S52 GO:0018492 1/344 carbon-monoxide dehydrogenase (acceptor) activity molecular_function "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] EOG873S52 GO:0007155 1/344 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG873S52 GO:0016020 1/344 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8V45P7 GO:2000601 28/98 positive regulation of Arp2/3 complex-mediated actin nucleation biological_process "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] EOG8V45P7 GO:0007015 27/98 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8V45P7 GO:0034314 1/98 Arp2/3 complex-mediated actin nucleation biological_process "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] EOG8V45P7 GO:0016203 1/98 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8V45P7 GO:0008407 1/98 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8V45P7 GO:0007286 1/98 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8V45P7 GO:0006886 1/98 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8V45P7 GO:0045886 1/98 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8V45P7 GO:0007409 1/98 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8V45P7 GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8V45P7 GO:0016476 1/98 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8V45P7 GO:0030833 1/98 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8V45P7 GO:0009913 1/98 epidermal cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] EOG8V45P7 GO:0006900 1/98 membrane budding biological_process "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] EOG8V45P7 GO:0007423 1/98 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8V45P7 GO:0035212 1/98 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG8V45P7 GO:0072583 1/98 clathrin-mediated endocytosis biological_process "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] EOG8V45P7 GO:0003779 1/98 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8V45P7 GO:0008582 1/98 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8V45P7 GO:0007413 1/98 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8V45P7 GO:0001578 1/98 microtubule bundle formation biological_process "A process that results in a parallel arrangement of microtubules." [GOC:dph] EOG8V45P7 GO:0045165 1/98 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG8V45P7 GO:0035017 1/98 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG8V45P7 GO:0003383 1/98 apical constriction biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8V45P7 GO:0016028 1/98 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8V45P7 GO:0007520 1/98 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8V45P7 GO:0005199 1/98 structural constituent of cell wall molecular_function "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] EOG8V45P7 GO:0005902 1/98 microvillus cellular_component "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] EOG8V45P7 GO:0008356 1/98 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8V45P7 GO:0005515 1/98 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8V45P7 GO:0005634 1/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PG8GG GO:0005272 20/84 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8PG8GG GO:0016021 19/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PG8GG GO:0016020 1/84 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG86HJW1 GO:0003677 3/4 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86HJW1 GO:0004518 3/4 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG854CG0 GO:0042302 100/239 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG854CG0 GO:0031012 1/239 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG854CG0 GO:0008010 1/239 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG854CG0 GO:0005199 1/239 structural constituent of cell wall molecular_function "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] EOG854CG0 GO:0040003 1/239 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG854CG0 GO:0016892 1/239 endoribonuclease activity, producing 3'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] EOG854CG0 GO:0003676 1/239 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BCH42 GO:0016020 2/5 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BCH42 GO:0009306 2/5 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG854CG5 GO:0006486 1/4 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG854CG5 GO:0016021 1/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG854CG5 GO:0005794 1/4 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG854CG5 GO:0047915 1/4 ganglioside galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] EOG83V2BM GO:0003676 4/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83V2BM GO:0046872 4/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86Q97P GO:0016021 129/334 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97P GO:0004672 1/334 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG86Q97P GO:0005524 1/334 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86Q97P GO:0045169 1/334 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8GJ25Q GO:0003700 1/31 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8GJ25Q GO:0043565 1/31 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8GJ25Q GO:0005634 1/31 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG880MC0 GO:0004735 55/191 pyrroline-5-carboxylate reductase activity molecular_function "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] EOG880MC0 GO:0055129 40/191 L-proline biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] EOG880MC0 GO:0006561 15/191 proline biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] EOG8SXQT1 GO:0015450 24/96 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] EOG8SXQT1 GO:0006886 24/96 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8SXQT1 GO:0005743 23/96 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8SXQT1 GO:0071456 1/96 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8SXQT1 GO:0016787 1/96 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8Z38X6 GO:0000156 1/6 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8Z38X6 GO:0004673 1/6 protein histidine kinase activity molecular_function "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] EOG8Z38X6 GO:0006355 1/6 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Z38X6 GO:0005886 1/6 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8Z38X6 GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z38X6 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XWJD7 GO:0038032 22/98 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG8XWJD7 GO:0005057 21/98 receptor signaling protein activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] EOG8XWJD7 GO:0030695 15/98 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8XWJD7 GO:0014045 1/98 establishment of endothelial blood-brain barrier biological_process "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] EOG8XWJD7 GO:0008069 1/98 dorsal/ventral axis specification, ovarian follicular epithelium biological_process "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] EOG8XWJD7 GO:0009786 1/98 regulation of asymmetric cell division biological_process "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] EOG8XWJD7 GO:0000578 1/98 embryonic axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] EOG8XWJD7 GO:0007186 1/98 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8XWJD7 GO:0008105 1/98 asymmetric protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] EOG8XWJD7 GO:0005096 1/98 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8XWJD7 GO:0005886 1/98 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XWJD7 GO:0045179 1/98 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8XWJD7 GO:0010001 1/98 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8XWJD7 GO:0005515 1/98 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XWJD7 GO:0043547 1/98 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8XWJD7 GO:0007310 1/98 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8XWJD7 GO:0001965 1/98 G-protein alpha-subunit binding molecular_function "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] EOG8XWJD7 GO:0016324 1/98 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8XWJD7 GO:0009408 1/98 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8XWJD7 GO:0005092 1/98 GDP-dissociation inhibitor activity molecular_function "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] EOG8XWJD7 GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XWJD7 GO:0003015 1/98 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG8XWJD7 GO:0060857 1/98 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG8XWJD7 GO:0050790 1/98 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8XWJD7 GO:0007049 1/98 cell cycle biological_process "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] EOG8XWJD7 GO:0055059 1/98 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8XWJD7 GO:0008277 1/98 regulation of G-protein coupled receptor protein signaling pathway biological_process "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] EOG8XWJD7 GO:0006979 1/98 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8XWJD7 GO:0019991 1/98 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8XWJD7 GO:0050832 1/98 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8XWJD7 GO:0030866 1/98 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8XWJD7 GO:0007419 1/98 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8XWJD7 GO:0032291 1/98 axon ensheathment in central nervous system biological_process "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] EOG8XWJD7 GO:0007303 1/98 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8XWJD7 GO:0042594 1/98 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG86Q97N GO:0016021 3/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97N GO:0019646 3/36 aerobic electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] EOG86Q97N GO:0004129 3/36 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG86Q97N GO:0005739 2/36 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86Q97N GO:0005743 1/36 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8CVJMQ GO:0004867 19/114 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG8CVJMQ GO:0005576 1/114 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CVJMQ GO:0019226 1/114 transmission of nerve impulse biological_process "The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation." [GOC:curators, ISBN:0815316194] EOG8323DB GO:0006629 38/66 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8323DB GO:0005576 38/66 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8323DB GO:0016787 33/66 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8323DB GO:0003824 3/66 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8323DB GO:0004806 2/66 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG8323DB GO:0006644 1/66 phospholipid metabolic process biological_process "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8323DB GO:0005615 1/66 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8323DB GO:0022008 1/66 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8323DB GO:0032504 1/66 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8323DB GO:0004620 1/66 phospholipase activity molecular_function "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732] EOG8H1DFB GO:0004072 1/8 aspartate kinase activity molecular_function "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779] EOG8H1DFB GO:0008652 1/8 cellular amino acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] EOG87SVVD GO:0005634 25/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87SVVD GO:0003700 25/103 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG87SVVD GO:0007165 5/103 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG87SVVD GO:0003677 1/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87SVVD GO:0005737 1/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87SVVD GO:0051607 1/103 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG87SVVD GO:0006967 1/103 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG87SVVD GO:0045429 1/103 positive regulation of nitric oxide biosynthetic process biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] EOG87SVVD GO:0048935 1/103 peripheral nervous system neuron development biological_process "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] EOG87SVVD GO:0006974 1/103 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG87SVVD GO:0045089 1/103 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG87SVVD GO:0045944 1/103 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG87SVVD GO:0006963 1/103 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG87SVVD GO:0034198 1/103 cellular response to amino acid starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] EOG87SVVD GO:0008063 1/103 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG87SVVD GO:0061057 1/103 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG87SVVD GO:0048813 1/103 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG87SVVD GO:0005515 1/103 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87SVVD GO:0006964 1/103 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG87SVVD GO:0000981 1/103 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG87SVVD GO:0001077 1/103 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG87SVVD GO:0002230 1/103 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG87SVVD GO:0009617 1/103 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG87SVVD GO:0006366 1/103 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG87SVVD GO:0050829 1/103 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG87SVVD GO:0045087 1/103 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG87SVVD GO:0043565 1/103 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG87SVVD GO:0010628 1/103 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG87SVVD GO:0006955 1/103 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8XSP46 GO:0005634 29/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XSP46 GO:0006355 29/95 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8XSP46 GO:0016747 26/95 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8XSP46 GO:0004402 3/95 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8XSP46 GO:0006351 1/95 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8XSP46 GO:0046872 1/95 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XSP46 GO:0005705 1/95 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8XSP46 GO:0043524 1/95 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8XSP46 GO:0043967 1/95 histone H4 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] EOG8XSP46 GO:2000331 1/95 regulation of terminal button organization biological_process "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] EOG8XSP46 GO:0016573 1/95 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8XSP46 GO:0006974 1/95 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8XSP46 GO:0010468 1/95 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8XSP46 GO:0043486 1/95 histone exchange biological_process "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] EOG8XSP46 GO:0007399 1/95 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8XSP46 GO:0035267 1/95 NuA4 histone acetyltransferase complex cellular_component "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] EOG8XSP46 GO:0000123 1/95 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8XSP46 GO:0048167 1/95 regulation of synaptic plasticity biological_process "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] EOG87SVVZ GO:0016772 4/16 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG87SVVZ GO:0016301 2/16 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG87SVVZ GO:0008270 1/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG818F2D GO:0016021 43/132 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG818F2D GO:0044070 1/132 regulation of anion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG818F2D GO:0005247 1/132 voltage-gated chloride channel activity molecular_function "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG818F2D GO:0050829 1/132 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG818F2D GO:0005229 1/132 intracellular calcium activated chloride channel activity molecular_function "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] EOG818F2D GO:0006821 1/132 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG818F2D GO:1902476 1/132 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG8NS5V3 GO:0030154 5/82 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8NS5V3 GO:0007548 5/82 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG87SVVR GO:0016117 3/10 carotenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] EOG87SVVR GO:0055114 3/10 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8XSP4F GO:0005975 92/241 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8XSP4F GO:0043169 75/241 cation binding molecular_function "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] EOG8XSP4F GO:0016798 56/241 hydrolase activity, acting on glycosyl bonds molecular_function "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] EOG8XSP4F GO:0003824 19/241 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8XSP4F GO:0004556 17/241 alpha-amylase activity molecular_function "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1] EOG8XSP4F GO:0046872 14/241 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XSP4F GO:0005576 10/241 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP4F GO:0005509 2/241 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XSP4F GO:0030170 1/241 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8XSP4F GO:0016740 1/241 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8XSP4F GO:0009058 1/241 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8XSP4C GO:0004571 37/107 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity molecular_function "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] EOG8XSP4C GO:0005509 37/107 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XSP4C GO:0016020 36/107 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XSP4C GO:0000139 1/107 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8XSP4C GO:0006486 1/107 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8XSP4C GO:0035010 1/107 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8XSP4C GO:0008340 1/107 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8XSP4C GO:0072347 1/107 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG8XSP4C GO:0016021 1/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80S2WJ GO:0016491 161/516 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80S2WJ GO:0004032 11/516 alditol:NADP+ 1-oxidoreductase activity molecular_function "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] EOG80S2WJ GO:0035220 1/516 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG80S2WJ GO:0047006 1/516 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity molecular_function "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] EOG80S2WJ GO:0016319 1/516 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG80S2WJ GO:0008106 1/516 alcohol dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] EOG80S2WJ GO:0022416 1/516 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8XSP4N GO:0020037 39/685 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8XSP4N GO:0006629 26/685 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8XSP4N GO:0046872 15/685 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XSP4N GO:0005576 13/685 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP4N GO:0016717 12/685 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG8XSP4N GO:0005506 12/685 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8XSP4N GO:0006633 12/685 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8XSP4N GO:0042438 9/685 melanin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] EOG8XSP4N GO:0016853 9/685 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8XSP4N GO:0048067 9/685 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG8XSP4N GO:0007275 3/685 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8XSP4N GO:0016021 2/685 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XSP4N GO:0004965 1/685 G-protein coupled GABA receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] EOG8XSP4N GO:0004930 1/685 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8XSP4N GO:0048082 1/685 regulation of adult chitin-containing cuticle pigmentation biological_process "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] EOG8XSP4N GO:0005739 1/685 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8XSP4N GO:0006583 1/685 melanin biosynthetic process from tyrosine biological_process "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] EOG8XSP4N GO:0007602 1/685 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8XSP4N GO:0007601 1/685 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8XSP4N GO:0005737 1/685 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XSP4N GO:0018298 1/685 protein-chromophore linkage biological_process "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] EOG8XSP4N GO:0005811 1/685 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8XSP4N GO:0046331 1/685 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XSP4N GO:0009881 1/685 photoreceptor activity molecular_function "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] EOG8XSP4N GO:0060179 1/685 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8XSP4N GO:0048066 1/685 developmental pigmentation biological_process "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] EOG8XSP4N GO:0048065 1/685 male courtship behavior, veined wing extension biological_process "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG8XSP4N GO:0070451 1/685 cell hair cellular_component "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] EOG84TRNM GO:0003713 4/44 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG84TRNM GO:0005634 4/44 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87WR3H GO:0016301 1/81 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8DV83N GO:0004930 2/13 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DV83N GO:0016021 2/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DV83H GO:0004842 1/3 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8C2KQX GO:0005634 36/172 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8C2KQX GO:0003677 36/172 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C2KQX GO:0006260 35/172 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8C2KQX GO:0003676 13/172 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8C2KQX GO:0005875 1/172 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8C2KQX GO:0005524 1/172 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8C2KQX GO:0004674 1/172 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8C2KQX GO:0006261 1/172 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG8C2KQX GO:0008270 1/172 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C2KQX GO:0048812 1/172 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8C2KQX GO:0007052 1/172 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8C2KQX GO:0007095 1/172 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8C2KQX GO:0005662 1/172 DNA replication factor A complex cellular_component "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] EOG8C2KQX GO:0003697 1/172 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG8C2KQX GO:0016787 1/172 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C2KQX GO:0046872 1/172 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8K6JKP GO:0030246 32/92 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8K6JKP GO:0003779 1/92 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8HB11V GO:0016020 6/41 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HB11V GO:0008107 6/41 galactoside 2-alpha-L-fucosyltransferase activity molecular_function "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] EOG8XWJDC GO:0008565 1/6 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8XWJDC GO:0019867 1/6 outer membrane cellular_component "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] EOG8XWJDC GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJDC GO:0042626 1/6 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8XWJDC GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XWJDC GO:0009306 1/6 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG88WFHJ GO:0070026 12/41 nitric oxide binding molecular_function "Interacting selectively and non-covalently with nitric oxide (NO)." [GOC:ecd] EOG88WFHJ GO:0051381 12/41 histamine binding molecular_function "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] EOG88WFHJ GO:0030682 2/41 evasion or tolerance of host defense response biological_process "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] EOG88WFHJ GO:0005576 1/41 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88WFHJ GO:0032504 1/41 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG88WFHJ GO:0031409 1/41 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG88WFHJ GO:0005615 1/41 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8SXQTF GO:0016020 31/102 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8SXQTF GO:0016628 4/102 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8SXQTF GO:0047598 3/102 7-dehydrocholesterol reductase activity molecular_function "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21] EOG8SXQTF GO:0003677 2/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SXQTF GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SXQTF GO:0046907 1/102 intracellular transport biological_process "The directed movement of substances within a cell." [GOC:ai] EOG8SXQTF GO:0050613 1/102 delta14-sterol reductase activity molecular_function "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] EOG8SXQTF GO:0005637 1/102 nuclear inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] EOG8SXQTF GO:0005639 1/102 integral component of nuclear inner membrane cellular_component "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] EOG8SXQTF GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SXQTF GO:0003682 1/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8SXQTF GO:0003700 1/102 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SXQTF GO:0006997 1/102 nucleus organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] EOG8SXQTF GO:0043565 1/102 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8SXQTF GO:0005635 1/102 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG8SXQTF GO:0005521 1/102 lamin binding molecular_function "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732] EOG8WQ3GD GO:0008270 16/46 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WQ3GD GO:0008237 16/46 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8WQ3GD GO:0004177 2/46 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8WQ3GG GO:0008565 26/99 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8WQ3GG GO:0006886 26/99 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8WQ3GG GO:0030131 25/99 clathrin adaptor complex cellular_component "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] EOG8WQ3GG GO:0016192 23/99 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8WQ3GG GO:0015031 3/99 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8WQ3GG GO:0005886 3/99 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WQ3GG GO:0048488 3/99 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8WQ3GG GO:0005905 3/99 coated pit cellular_component "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] EOG8WQ3GG GO:0030100 1/99 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8WQ3GG GO:0006901 1/99 vesicle coating biological_process "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] EOG8WQ3GG GO:0008104 1/99 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8WQ3GG GO:0008021 1/99 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8WQ3GG GO:0007269 1/99 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8WQ3GG GO:0045807 1/99 positive regulation of endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8WQ3GG GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WQ3GG GO:0048489 1/99 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8WQ3GG GO:0008356 1/99 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8WQ3GG GO:0006897 1/99 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8WQ3GG GO:0030122 1/99 AP-2 adaptor complex cellular_component "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499] EOG8WQ3GG GO:0030135 1/99 coated vesicle cellular_component "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] EOG8WQ3GG GO:0016183 1/99 synaptic vesicle coating biological_process "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709] EOG8NZX7W GO:0003676 8/36 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NZX7W GO:0016307 1/36 phosphatidylinositol phosphate kinase activity molecular_function "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] EOG8NZX7W GO:0003723 1/36 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NZX7W GO:0003964 1/36 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8SXQTM GO:0005576 26/89 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8SXQTM GO:0003713 1/89 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8SXQTM GO:0006406 1/89 mRNA export from nucleus biological_process "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] EOG8SXQTM GO:0000124 1/89 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG8SXQTM GO:0045893 1/89 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SXQTM GO:0005643 1/89 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8XWJDR GO:0005840 64/138 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8XWJDR GO:0003735 64/138 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8XWJDR GO:0006412 64/138 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WQ3GT GO:0004831 27/100 tyrosine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223] EOG8WQ3GT GO:0005524 27/100 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WQ3GT GO:0006437 26/100 tyrosyl-tRNA aminoacylation biological_process "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8WQ3GT GO:0005737 26/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WQ3GT GO:0000049 25/100 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG8WQ3GT GO:0006418 1/100 tRNA aminoacylation for protein translation biological_process "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] EOG854CGK GO:0003713 24/92 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG854CGK GO:0006355 23/92 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG854CGK GO:0003677 23/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG854CGK GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG854CGK GO:0006351 1/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG854CGK GO:0045892 1/92 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG854CGK GO:0003697 1/92 single-stranded DNA binding molecular_function "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174] EOG8WQ3GQ GO:0004619 4/17 phosphoglycerate mutase activity molecular_function "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] EOG8WQ3GQ GO:0030145 4/17 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG8WQ3GQ GO:0006007 4/17 glucose catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] EOG8WQ3GQ GO:0005737 4/17 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WQ3GS GO:0004348 80/206 glucosylceramidase activity molecular_function "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] EOG8WQ3GS GO:0005975 80/206 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WQ3GS GO:0006665 80/206 sphingolipid metabolic process biological_process "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8WQ3GS GO:0034620 2/206 cellular response to unfolded protein biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] EOG8WQ3GS GO:0008234 1/206 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8SR0BM GO:0005634 28/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SR0BM GO:0003707 26/104 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8SR0BM GO:0043565 22/104 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8SR0BM GO:0008270 22/104 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SR0BM GO:0006351 19/104 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SR0BM GO:0003700 19/104 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SR0BM GO:0004879 8/104 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8SR0BM GO:0003677 6/104 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SR0BM GO:0048842 1/104 positive regulation of axon extension involved in axon guidance biological_process "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] EOG8SR0BM GO:0030522 1/104 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG8SR0BM GO:0031103 1/104 axon regeneration biological_process "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] EOG8SR0BM GO:0020037 1/104 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8SR0BM GO:0022008 1/104 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SR0BM GO:0007411 1/104 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SR0BM GO:0016322 1/104 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8SR0BM GO:0048526 1/104 imaginal disc-derived wing expansion biological_process "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] EOG8SR0BM GO:0016319 1/104 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8SR0BM GO:0004887 1/104 thyroid hormone receptor activity molecular_function "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling] EOG86DPKV GO:0004725 1/4 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8SR0BJ GO:0016021 1/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SR0BJ GO:0043025 1/79 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8SR0BJ GO:0007399 1/79 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8DRCZD GO:0030246 1/4 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8P2SG7 GO:0005267 23/95 potassium channel activity molecular_function "Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8P2SG7 GO:0016021 23/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N333H GO:0004252 26/45 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8N333H GO:0006508 2/45 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8N333H GO:0016787 1/45 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8N333H GO:0022008 1/45 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8N333H GO:0004175 1/45 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8S7N54 GO:0005975 19/45 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8S7N54 GO:0004553 17/45 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8S7N54 GO:0003940 2/45 L-iduronidase activity molecular_function "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] EOG88PQ0H GO:0005869 2/120 dynactin complex cellular_component "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] EOG88PQ0H GO:0007018 2/120 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG88PQ0H GO:0045502 1/120 dynein binding molecular_function "Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf] EOG88PQ0H GO:0045198 1/120 establishment of epithelial cell apical/basal polarity biological_process "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] EOG88PQ0H GO:0031616 1/120 spindle pole centrosome cellular_component "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] EOG88PQ0H GO:0007067 1/120 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG88PQ0H GO:0048491 1/120 retrograde synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body." [GOC:jid, GOC:lmg] EOG88PQ0H GO:0005813 1/120 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG88PQ0H GO:0048477 1/120 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG88PQ0H GO:0051383 1/120 kinetochore organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG88PQ0H GO:0005737 1/120 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88PQ0H GO:0042052 1/120 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG88PQ0H GO:0007052 1/120 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG88PQ0H GO:0005876 1/120 spindle microtubule cellular_component "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] EOG88PQ0H GO:0000776 1/120 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG88PQ0H GO:0051299 1/120 centrosome separation biological_process "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] EOG88PQ0H GO:0006886 1/120 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG88PQ0H GO:0047497 1/120 mitochondrion transport along microtubule biological_process "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] EOG88PQ0H GO:0001709 1/120 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] EOG88PQ0H GO:0051256 1/120 mitotic spindle midzone assembly biological_process "The cell cycle process, occurring during anaphase, in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw] EOG88PQ0H GO:0051642 1/120 centrosome localization biological_process "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG88PQ0H GO:0005818 1/120 aster cellular_component "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] EOG88PQ0H GO:0008090 1/120 retrograde axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] EOG88PQ0H GO:0051225 1/120 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG88PQ0H GO:0042051 1/120 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG88PQ0H GO:0030496 1/120 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG88PQ0H GO:0034501 1/120 protein localization to kinetochore biological_process "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] EOG88PQ0H GO:0035371 1/120 microtubule plus-end cellular_component "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] EOG88PQ0H GO:0001754 1/120 eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] EOG88PQ0H GO:0003774 1/120 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG88PQ0H GO:0001751 1/120 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG88PQ0H GO:0022008 1/120 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG88PQ0H GO:0016330 1/120 second mitotic wave involved in compound eye morphogenesis biological_process "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] EOG88PQ0H GO:0051028 1/120 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG88PQ0H GO:0035011 1/120 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG88PQ0H GO:0030286 1/120 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG88PQ0H GO:0005828 1/120 kinetochore microtubule cellular_component "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] EOG8VMHVD GO:0005777 43/126 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8VMHVD GO:0010468 43/126 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8VMHVD GO:0048477 43/126 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8VMHVD GO:0003676 16/126 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VMHVD GO:0000166 9/126 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8VMHVD GO:0008270 1/126 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N58 GO:0008270 8/24 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N58 GO:0004518 7/24 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8S7N58 GO:0003677 7/24 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VHNM6 GO:0003676 56/206 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VHNM6 GO:0005524 56/206 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VHNM6 GO:0008026 54/206 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8VHNM6 GO:0000398 2/206 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8VHNM6 GO:0004386 2/206 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VHNM6 GO:0003724 1/206 RNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] EOG8VHNM6 GO:0008565 1/206 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8VHNM6 GO:0071013 1/206 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8VHNM6 GO:0006200 1/206 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8VHNM6 GO:0030532 1/206 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8VHNM6 GO:0005622 1/206 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8VHNM6 GO:0031204 1/206 posttranslational protein targeting to membrane, translocation biological_process "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] EOG8VHNM6 GO:0008380 1/206 RNA splicing biological_process "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] EOG8VHNM6 GO:0005682 1/206 U5 snRNP cellular_component "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] EOG8VHNM6 GO:0005681 1/206 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8VHNM6 GO:0000381 1/206 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8VHNM6 GO:0005634 1/206 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VHNM6 GO:0004004 1/206 ATP-dependent RNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] EOG8VHNM6 GO:0071011 1/206 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8VHNM6 GO:0007067 1/206 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG844P06 GO:0016021 81/188 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG844P06 GO:0005524 81/188 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG844P06 GO:0042626 77/188 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG844P06 GO:0008559 6/188 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG844P06 GO:0031427 4/188 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG844P06 GO:0005886 4/188 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG844P06 GO:0055085 4/188 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG844P06 GO:0015440 2/188 peptide-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] EOG844P06 GO:0006855 2/188 drug transmembrane transport biological_process "The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf] EOG844P06 GO:0015238 1/188 drug transmembrane transporter activity molecular_function "Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732] EOG844P06 GO:0060857 1/188 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG844P06 GO:0008354 1/188 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG844P06 GO:0042908 1/188 xenobiotic transport biological_process "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] EOG844P06 GO:0001666 1/188 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG844P06 GO:0005919 1/188 pleated septate junction cellular_component "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] EOG844P06 GO:0015562 1/188 efflux transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG844P06 GO:0043190 1/188 ATP-binding cassette (ABC) transporter complex cellular_component "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] EOG844P06 GO:0005887 1/188 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89CSPQ GO:0003676 21/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8P5NQB GO:0016020 20/138 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8003ZX GO:0016020 25/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8003ZX GO:0007140 1/91 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG8003ZX GO:0008054 1/91 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8P5NQD GO:0003723 1/15 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FXTP9 GO:0005576 7/57 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FXTP9 GO:0006629 7/57 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8FXTP9 GO:0016787 5/57 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8FXTP9 GO:0003824 2/57 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG889719 GO:0005524 280/803 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG889719 GO:0016021 278/803 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG889719 GO:0042626 272/803 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008559 6/803 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG889719 GO:0032440 5/803 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG889719 GO:0003676 2/803 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG889719 GO:0016887 2/803 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008270 2/803 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG889719 GO:0042060 1/803 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG889719 GO:0000776 1/803 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG889719 GO:0048190 1/803 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG889719 GO:0006200 1/803 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG889719 GO:0034508 1/803 centromere complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] EOG889719 GO:0046688 1/803 response to copper ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] EOG889719 GO:0034059 1/803 response to anoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] EOG889719 GO:0046331 1/803 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG889719 GO:0007275 1/803 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG889719 GO:0010043 1/803 response to zinc ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] EOG889719 GO:0031427 1/803 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG889719 GO:0001666 1/803 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG889719 GO:0043492 1/803 ATPase activity, coupled to movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] EOG8003ZG GO:0043565 20/88 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8003ZG GO:0003700 19/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8003ZG GO:0046872 6/88 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8003ZG GO:0003676 2/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8003ZG GO:0005634 2/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8003ZG GO:0010866 1/88 regulation of triglyceride biosynthetic process biological_process "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] EOG8003ZG GO:0002385 1/88 mucosal immune response biological_process "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] EOG8003ZG GO:0031453 1/88 positive regulation of heterochromatin assembly biological_process "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] EOG8003ZG GO:0031618 1/88 nuclear pericentric heterochromatin cellular_component "Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993] EOG8003ZG GO:0051403 1/88 stress-activated MAPK cascade biological_process "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] EOG8003ZG GO:0045944 1/88 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8003ZG GO:0005701 1/88 polytene chromosome chromocenter cellular_component "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] EOG8003ZG GO:0009651 1/88 response to salt stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] EOG8003ZG GO:0005509 1/88 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8003ZG GO:0070829 1/88 heterochromatin maintenance biological_process "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] EOG8003ZG GO:0001077 1/88 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG8003ZG GO:0042803 1/88 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8003ZG GO:0034605 1/88 cellular response to heat biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] EOG8003ZG GO:0005704 1/88 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG8003ZG GO:0030431 1/88 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8003ZG GO:0071470 1/88 cellular response to osmotic stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] EOG8003ZF GO:0005737 73/266 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8003ZF GO:0008565 73/266 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8003ZF GO:0005634 73/266 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8003ZF GO:0006606 72/266 protein import into nucleus biological_process "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] EOG8003ZF GO:0017022 1/266 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8003ZF GO:0007291 1/266 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8003ZF GO:0051298 1/266 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8003ZF GO:0042332 1/266 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG8003ZF GO:0005811 1/266 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8003ZF GO:0007283 1/266 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8003ZF GO:0051533 1/266 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8003ZF GO:0007095 1/266 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8003ZF GO:0009411 1/266 response to UV biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] EOG8003ZF GO:0006607 1/266 NLS-bearing protein import into nucleus biological_process "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] EOG8003ZF GO:0005875 1/266 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8003ZF GO:0048542 1/266 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8003ZF GO:0007301 1/266 female germline ring canal formation biological_process "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] EOG8FJBR5 GO:0008270 1/185 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FJBR5 GO:0003677 1/185 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG889716 GO:0007018 26/86 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG889716 GO:0003777 26/86 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG889716 GO:0030286 23/86 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG889716 GO:0005524 19/86 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG889716 GO:0016887 15/86 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG889716 GO:0006200 1/86 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG889716 GO:0006281 1/86 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG889716 GO:0003677 1/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG889716 GO:0005875 1/86 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG889716 GO:0042623 1/86 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8003Z2 GO:0003824 1/8 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG88971K GO:0017153 33/151 sodium:dicarboxylate symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] EOG88971K GO:0016020 32/151 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88971K GO:0015183 1/151 L-aspartate transmembrane transporter activity molecular_function "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] EOG88971K GO:0005313 1/151 L-glutamate transmembrane transporter activity molecular_function "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG88971K GO:0005886 1/151 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88971K GO:0015501 1/151 glutamate:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] EOG88971K GO:0007268 1/151 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG88971K GO:0015810 1/151 aspartate transport biological_process "The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] EOG88971K GO:0016021 1/151 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88971K GO:0043195 1/151 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG88971K GO:0015813 1/151 L-glutamate transport biological_process "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb] EOG88971K GO:0008345 1/151 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG88971K GO:0043005 1/151 neuron projection cellular_component "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] EOG88971K GO:0014853 1/151 regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction biological_process "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] EOG88971K GO:0008340 1/151 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8FJBRF GO:0042302 572/1336 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8FJBRF GO:0040003 37/1336 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8FJBRF GO:0008010 37/1336 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0031012 37/1336 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8FJBRF GO:0005576 13/1336 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FJBRF GO:0008363 8/1336 larval chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8FJBRF GO:0005215 7/1336 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FJBRF GO:0008011 2/1336 structural constituent of pupal chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0005615 1/1336 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8FJBRF GO:0032504 1/1336 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8FJBRF GO:0042381 1/1336 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8VT8BR GO:0019277 1/11 UDP-N-acetylgalactosamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] EOG8VT8BR GO:0008760 1/11 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity molecular_function "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18684] EOG8FXTPR GO:0003677 17/116 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FXTPR GO:0046872 4/116 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FXTPR GO:0003676 2/116 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88971B GO:0005524 59/204 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88971B GO:0004713 35/204 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG88971B GO:0016021 30/204 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88971B GO:0004714 21/204 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG88971B GO:0007169 19/204 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG88971B GO:0016020 13/204 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88971B GO:0004672 4/204 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG88971B GO:0061327 1/204 anterior Malpighian tubule development biological_process "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG88971B GO:0045087 1/204 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG88971B GO:0007015 1/204 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG88971B GO:0043066 1/204 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG88971B GO:0045610 1/204 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG88971B GO:0007419 1/204 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG88971B GO:0038202 1/204 TORC1 signaling biological_process "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] EOG88971B GO:0008360 1/204 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG88971B GO:0036335 1/204 intestinal stem cell homeostasis biological_process "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] EOG88971B GO:0035099 1/204 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG88971B GO:0019730 1/204 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG88971B GO:0030031 1/204 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG88971B GO:0007443 1/204 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG88971B GO:0048803 1/204 imaginal disc-derived male genitalia morphogenesis biological_process "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] EOG88971B GO:0007298 1/204 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG88971B GO:0007435 1/204 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG88971B GO:0000022 1/204 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG88971B GO:0043410 1/204 positive regulation of MAPK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] EOG88971B GO:0030097 1/204 hemopoiesis biological_process "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] EOG88971B GO:0005886 1/204 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88971B GO:0006468 1/204 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG88971B GO:0005515 1/204 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88971B GO:0007516 1/204 hemocyte development biological_process "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG88971B GO:0006974 1/204 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG88971B GO:0018108 1/204 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG88971B GO:0035172 1/204 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG88971B GO:0032869 1/204 cellular response to insulin stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] EOG88971B GO:0030036 1/204 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0005525 83/290 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8FXTPX GO:0007264 81/290 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8FXTPX GO:0005622 81/290 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8FXTPX GO:0016020 77/290 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0005886 5/290 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FXTPX GO:0004767 4/290 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8FXTPX GO:0031532 4/290 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8FXTPX GO:0005912 4/290 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8FXTPX GO:0035099 4/290 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8FXTPX GO:0007391 4/290 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FXTPX GO:0090303 4/290 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8FXTPX GO:0007254 4/290 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8FXTPX GO:0007275 3/290 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FXTPX GO:0050770 3/290 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG8FXTPX GO:0007394 3/290 dorsal closure, elongation of leading edge cells biological_process "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] EOG8FXTPX GO:0051017 3/290 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG8FXTPX GO:0006184 3/290 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8FXTPX GO:0006909 3/290 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8FXTPX GO:0008258 3/290 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8FXTPX GO:0003924 3/290 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8FXTPX GO:0045185 3/290 maintenance of protein location biological_process "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] EOG8FXTPX GO:0035011 3/290 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8FXTPX GO:0030032 3/290 lamellipodium assembly biological_process "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0007390 3/290 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8FXTPX GO:0005515 3/290 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FXTPX GO:0046843 3/290 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8FXTPX GO:0035010 3/290 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8FXTPX GO:0007435 3/290 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8FXTPX GO:0045860 3/290 positive regulation of protein kinase activity biological_process "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG8FXTPX GO:0006974 2/290 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8FXTPX GO:0007424 2/290 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8FXTPX GO:0050975 2/290 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG8FXTPX GO:0002009 2/290 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8FXTPX GO:0008045 2/290 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8FXTPX GO:0007411 2/290 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FXTPX GO:0007015 2/290 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8FXTPX GO:0007520 2/290 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8FXTPX GO:0002433 2/290 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis biological_process "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] EOG8FXTPX GO:0031175 2/290 neuron projection development biological_process "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] EOG8FXTPX GO:0007426 2/290 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0048813 2/290 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8FXTPX GO:0030707 2/290 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FXTPX GO:0042067 2/290 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG8FXTPX GO:0030036 2/290 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0016203 2/290 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8FXTPX GO:0051491 2/290 positive regulation of filopodium assembly biological_process "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0000902 2/290 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8FXTPX GO:0016028 2/290 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8FXTPX GO:0097206 2/290 nephrocyte filtration biological_process "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] EOG8FXTPX GO:0032794 2/290 GTPase activating protein binding molecular_function "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] EOG8FXTPX GO:0030866 2/290 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0034334 2/290 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG8FXTPX GO:0007266 2/290 Rho protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] EOG8FXTPX GO:0007516 1/290 hemocyte development biological_process "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0016199 1/290 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8FXTPX GO:0007017 1/290 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8FXTPX GO:0010592 1/290 positive regulation of lamellipodium assembly biological_process "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8FXTPX GO:0051450 1/290 myoblast proliferation biological_process "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] EOG8FXTPX GO:0051963 1/290 regulation of synapse assembly biological_process "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] EOG8FXTPX GO:0007413 1/290 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8FXTPX GO:0007617 1/290 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8FXTPX GO:0030041 1/290 actin filament polymerization biological_process "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8FXTPX GO:0005829 1/290 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8FXTPX GO:0060446 1/290 branching involved in open tracheal system development biological_process "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] EOG8FXTPX GO:0045177 1/290 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0051726 1/290 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0035320 1/290 imaginal disc-derived wing hair site selection biological_process "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] EOG8FXTPX GO:0008347 1/290 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8FXTPX GO:0007422 1/290 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8FXTPX GO:0007396 1/290 suture of dorsal opening biological_process "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] EOG8FXTPX GO:0010593 1/290 negative regulation of lamellipodium assembly biological_process "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8FXTPX GO:0005938 1/290 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0071907 1/290 determination of digestive tract left/right asymmetry biological_process "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs] EOG8FXTPX GO:0048615 1/290 embryonic anterior midgut (ectodermal) morphogenesis biological_process "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG8FXTPX GO:0042742 1/290 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8FXTPX GO:0045200 1/290 establishment of neuroblast polarity biological_process "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0010883 1/290 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG8FXTPX GO:0008360 1/290 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FXTPX GO:0048747 1/290 muscle fiber development biological_process "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] EOG8FXTPX GO:0007631 1/290 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8FXTPX GO:0030011 1/290 maintenance of cell polarity biological_process "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8FXTPX GO:0002118 1/290 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG8FXTPX GO:0030031 1/290 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8FXTPX GO:0007286 1/290 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8FXTPX GO:0046331 1/290 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8FXTPX GO:0019897 1/290 extrinsic component of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] EOG8FXTPX GO:0048477 1/290 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8FXTPX GO:0045610 1/290 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8FXTPX GO:0071902 1/290 positive regulation of protein serine/threonine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] EOG8FXTPX GO:0007274 1/290 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8FXTPX GO:0007419 1/290 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8FXTPX GO:0048675 1/290 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8FXTPX GO:0030426 1/290 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8FXTPX GO:0007409 1/290 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8FXTPX GO:0008078 1/290 mesodermal cell migration biological_process "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] EOG8FXTPX GO:0030833 1/290 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8FXTPX GO:0035318 1/290 imaginal disc-derived wing hair outgrowth biological_process "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] EOG8FXTPX GO:0008582 1/290 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8FXTPX GO:0035212 1/290 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG8FXTPX GO:0030424 1/290 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8FXTPX GO:0016335 1/290 morphogenesis of larval imaginal disc epithelium biological_process "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] EOG8FXTPX GO:0001737 1/290 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8FXTPX GO:0045216 1/290 cell-cell junction organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0051301 1/290 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8FXTPX GO:0007298 1/290 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FXTPX GO:0042052 1/290 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8FXTPX GO:0007179 1/290 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8FXTPX GO:0048814 1/290 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8FXTPX GO:0005737 1/290 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FXTPX GO:0050807 1/290 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0008283 1/290 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8FXTPX GO:0042060 1/290 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8FXTPX GO:0007164 1/290 establishment of tissue polarity biological_process "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] EOG8FXTPX GO:0046664 1/290 dorsal closure, amnioserosa morphology change biological_process "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] EOG8FXTPX GO:0007010 1/290 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0007349 1/290 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8FXTPX GO:0005634 1/290 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88971D GO:0016192 24/96 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG88971D GO:0006886 24/96 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG88971D GO:0005198 24/96 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG88971D GO:0030117 23/96 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG88971D GO:0016905 2/96 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG88971D GO:0005795 1/96 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG88971D GO:0003824 1/96 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG88971D GO:0030126 1/96 COPI vesicle coat cellular_component "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] EOG88971D GO:0010883 1/96 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG844P0X GO:0006434 1/6 seryl-tRNA aminoacylation biological_process "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG844P0X GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG844P0X GO:0005737 1/6 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG844P0X GO:0004828 1/6 serine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] EOG8FXTPB GO:0016021 2/48 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FXTPB GO:0004721 2/48 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG88971R GO:0004177 1/10 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG88971R GO:0008235 1/10 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG88971R GO:0030145 1/10 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG88971R GO:0005737 1/10 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P5NQ5 GO:0006097 1/99 glyoxylate cycle biological_process "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] EOG8P5NQ5 GO:0004474 1/99 malate synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184] EOG8P2SGG GO:0003676 1/11 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8P2SGG GO:0006260 1/11 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8P2SGG GO:0043140 1/11 ATP-dependent 3'-5' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] EOG8P2SGG GO:0005524 1/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8P2SGG GO:0005622 1/11 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8P2SGG GO:0006281 1/11 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8Z0DM0 GO:0005525 49/153 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8Z0DM0 GO:0003924 48/153 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8Z0DM0 GO:0003746 25/153 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8Z0DM0 GO:0005622 22/153 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8Z0DM0 GO:0016779 2/153 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8Z0DM0 GO:0005739 1/153 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Z0DM0 GO:0008283 1/153 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8Z0DM0 GO:0007030 1/153 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8Z0DM0 GO:0000278 1/153 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8Z0DM0 GO:0004781 1/153 sulfate adenylyltransferase (ATP) activity molecular_function "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] EOG8QC3K3 GO:0030246 11/81 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8QC3K3 GO:0016787 2/81 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8QC3K3 GO:0004714 1/81 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8QC3K4 GO:0005524 25/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QC3K4 GO:0004674 23/98 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8QC3K4 GO:0016773 8/98 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8QC3K4 GO:0016301 7/98 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8QC3K4 GO:0001700 1/98 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8QC3K4 GO:0000076 1/98 DNA replication checkpoint biological_process "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] EOG8QC3K4 GO:0006468 1/98 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8QC3K4 GO:0000077 1/98 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG8QC3K4 GO:0016310 1/98 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8QC3K4 GO:0007444 1/98 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8QC3K4 GO:0007093 1/98 mitotic cell cycle checkpoint biological_process "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] EOG8QC3K4 GO:0000706 1/98 meiotic DNA double-strand break processing biological_process "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] EOG8QC3K4 GO:0030261 1/98 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8QC3K4 GO:0007095 1/98 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8QC3K4 GO:0007348 1/98 regulation of syncytial blastoderm mitotic cell cycle biological_process "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8QC3K4 GO:0006974 1/98 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8QC3K4 GO:0007349 1/98 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8QC3K4 GO:0005634 1/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QC3K4 GO:0045002 1/98 double-strand break repair via single-strand annealing biological_process "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529] EOG8QC3K4 GO:0009314 1/98 response to radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] EOG8QC3K4 GO:0048477 1/98 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8QC3K4 GO:0033314 1/98 mitotic DNA replication checkpoint biological_process "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] EOG8QC3K4 GO:0007015 1/98 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8QC3K4 GO:0016321 1/98 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8QC3K4 GO:0007088 1/98 regulation of mitotic nuclear division biological_process "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8QC3K4 GO:0004672 1/98 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QC3K4 GO:0007131 1/98 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8QC3K4 GO:0007126 1/98 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8QC3K4 GO:0000723 1/98 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8QC3K4 GO:0045003 1/98 double-strand break repair via synthesis-dependent strand annealing biological_process "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] EOG8QC3K4 GO:0006281 1/98 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8QC3K4 GO:0003677 1/98 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QC3K4 GO:0008360 1/98 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P2SGH GO:0003700 27/109 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8P2SGH GO:0005667 27/109 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8P2SGH GO:0005634 27/109 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8P2SGH GO:0007179 27/109 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8P2SGH GO:0006351 27/109 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8P2SGH GO:0006355 4/109 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8P2SGH GO:0005622 3/109 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8P2SGH GO:0045887 1/109 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8P2SGH GO:0005515 1/109 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8P2SGH GO:0030509 1/109 BMP signaling pathway biological_process "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034] EOG8P2SGH GO:0009953 1/109 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8P2SGH GO:0009950 1/109 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P2SGH GO:0043565 1/109 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8P2SGH GO:0005737 1/109 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P2SGH GO:0008283 1/109 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8P2SGH GO:0048666 1/109 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8P2SGH GO:0030718 1/109 germ-line stem cell population maintenance biological_process "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] EOG8P2SGH GO:0045705 1/109 negative regulation of salivary gland boundary specification biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] EOG8P2SGH GO:0042078 1/109 germ-line stem cell division biological_process "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] EOG8P2SGH GO:0030707 1/109 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8P2SGH GO:0007480 1/109 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8P2SGH GO:0031290 1/109 retinal ganglion cell axon guidance biological_process "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] EOG8P2SGH GO:0007507 1/109 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8P2SGH GO:0007476 1/109 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8P2SGH GO:0035019 1/109 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG89629W GO:0046872 1/2 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S7N5S GO:0030234 16/259 enzyme regulator activity molecular_function "Binds to and modulates the activity of an enzyme." [GOC:mah] EOG8S7N5S GO:0005509 16/259 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8S7N5S GO:0090256 1/259 regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis biological_process "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8S7N5S GO:0005615 1/259 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8S7N5S GO:0032504 1/259 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8S7N5S GO:0042302 1/259 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8S7N5S GO:0005811 1/259 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8S7N5S GO:0005576 1/259 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S7N5S GO:0005829 1/259 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8S7N5S GO:0009631 1/259 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG8S7N5S GO:0044720 1/259 negative regulation of imaginal disc-derived wing size biological_process "Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605] EOG8P2SGS GO:0016021 6/204 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8P2SGS GO:0055085 5/204 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8P2SGS GO:0005886 1/204 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8P2SGS GO:0003009 1/204 skeletal muscle contraction biological_process "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] EOG81C9CV GO:0005576 5/43 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81C9CV GO:0008061 5/43 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG81C9CV GO:0006030 5/43 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8C5G1B GO:0031083 1/56 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG8C5G1B GO:0005515 1/56 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8C5G1B GO:0008057 1/56 eye pigment granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] EOG8P2SGX GO:0005975 50/140 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8P2SGX GO:0004553 43/140 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8P2SGX GO:0004566 7/140 beta-glucuronidase activity molecular_function "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] EOG8P2SGX GO:0032504 1/140 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8P2SGX GO:0005615 1/140 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG88D39Z GO:0006744 32/131 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG88D39Z GO:0008425 32/131 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] EOG88D39Z GO:0008689 2/131 3-demethylubiquinone-9 3-O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] EOG88D39Z GO:0008757 1/131 S-adenosylmethionine-dependent methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] EOG88D39Z GO:0006470 1/131 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG88D39Z GO:0017017 1/131 MAP kinase tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] EOG88D39Z GO:0030798 1/131 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG88D39Z GO:0042060 1/131 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG88D39Z GO:0004395 1/131 hexaprenyldihydroxybenzoate methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] EOG8SFCMV GO:0016773 1/8 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8SFCMV GO:0016491 1/8 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8SFCMQ GO:0016746 15/48 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8SFCMQ GO:0005777 1/48 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8SFCMQ GO:0008458 1/48 carnitine O-octanoyltransferase activity molecular_function "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17180] EOG8GTNSN GO:0005509 5/40 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GTNSN GO:0005975 1/40 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8GTNSN GO:0016773 1/40 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG83BQ33 GO:0004177 167/275 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG83BQ33 GO:0005737 163/275 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ33 GO:0030145 163/275 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG83BQ33 GO:0008235 163/275 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG83BQ33 GO:0005622 4/275 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83BQ33 GO:0005615 1/275 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG83BQ33 GO:0003676 1/275 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83BQ33 GO:0032504 1/275 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG83BQ33 GO:0016319 1/275 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG83BQ33 GO:0016706 1/275 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG83BQ33 GO:0007498 1/275 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG83BQ33 GO:0015074 1/275 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8K9DVK GO:0035556 1/6 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG88D39J GO:0031409 3/20 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG88D39J GO:0005576 2/20 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87WR47 GO:0007411 1/84 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG87WR47 GO:0005886 1/84 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87WR47 GO:0016021 1/84 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87WR47 GO:0007413 1/84 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8BCH3M GO:0016740 1/5 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8BCH3M GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BCH3M GO:0016818 1/5 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] EOG8BCH3M GO:0006355 1/5 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8BCH3M GO:0005634 1/5 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HHRHQ GO:0008080 16/24 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8KM1JD GO:0006355 3/28 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8KM1JD GO:0003677 3/28 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BCH3D GO:0030246 25/87 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8GXJ45 GO:0016301 1/58 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8GXJ45 GO:0080019 1/58 fatty-acyl-CoA reductase (alcohol-forming) activity molecular_function "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] EOG8CJXZ7 GO:0005615 3/125 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8CJXZ7 GO:0042595 1/125 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8CJXZ7 GO:0007623 1/125 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8CJXZ7 GO:0008343 1/125 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG8CJXZ7 GO:0007622 1/125 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG8CJXZ7 GO:0007631 1/125 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8CJXZ7 GO:0007617 1/125 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8CJXZ7 GO:0005576 1/125 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CJXZ7 GO:0042594 1/125 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8CJXZ7 GO:0008049 1/125 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8S7N6K GO:0000166 1/33 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8R2686 GO:0016021 20/86 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R2686 GO:0055085 20/86 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8BZQH5 GO:0005524 27/158 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BZQH5 GO:0004674 23/158 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8BZQH5 GO:0050660 9/158 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8BZQH5 GO:0008812 8/158 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8BZQH5 GO:0006066 8/158 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8BZQH5 GO:0004672 4/158 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8BZQH5 GO:0016614 2/158 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8BZQH5 GO:0007348 1/158 regulation of syncytial blastoderm mitotic cell cycle biological_process "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8BZQH5 GO:0051299 1/158 centrosome separation biological_process "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] EOG8BZQH5 GO:0016321 1/158 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8BZQH5 GO:0004344 1/158 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG8BZQH5 GO:0007050 1/158 cell cycle arrest biological_process "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] EOG8BZQH5 GO:0042060 1/158 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8BZQH5 GO:0007095 1/158 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8BZQH5 GO:0051225 1/158 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8BZQH5 GO:0007444 1/158 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8BZQH5 GO:0007093 1/158 mitotic cell cycle checkpoint biological_process "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] EOG8BZQH5 GO:0009314 1/158 response to radiation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] EOG8BZQH5 GO:0030162 1/158 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8BZQH5 GO:0033314 1/158 mitotic DNA replication checkpoint biological_process "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] EOG8BZQH5 GO:0007349 1/158 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8BZQH5 GO:0001700 1/158 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8BZQH5 GO:0000075 1/158 cell cycle checkpoint biological_process "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] EOG8BZQH5 GO:0004683 1/158 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG8BZQH5 GO:0005634 1/158 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BZQH5 GO:0000077 1/158 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG8BZQH5 GO:0006468 1/158 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8HHRH4 GO:0055085 24/94 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8HHRH4 GO:0016021 24/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HHRH4 GO:0006727 1/94 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8HHRH4 GO:0046872 1/94 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HHRH4 GO:0003676 1/94 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HHRH5 GO:0003774 26/71 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8HHRH5 GO:0016459 26/71 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8HHRH5 GO:0005524 26/71 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HHRH5 GO:0016887 1/71 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8BZQHK GO:0018342 21/84 protein prenylation biological_process "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732] EOG8BZQHK GO:0008318 20/84 protein prenyltransferase activity molecular_function "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] EOG8BZQHK GO:0004663 1/84 Rab geranylgeranyltransferase activity molecular_function "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] EOG8BZQHK GO:0016740 1/84 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8HHRH2 GO:0006108 49/173 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG8HHRH2 GO:0051287 49/173 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8HHRH2 GO:0004471 49/173 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] EOG8HHRH2 GO:0046872 49/173 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HHRH2 GO:0010941 1/173 regulation of cell death biological_process "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] EOG8HHRH2 GO:0030431 1/173 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8HHRH2 GO:0008340 1/173 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8ZGRWM GO:0040008 2/90 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG8ZGRWM GO:0005938 1/90 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8ZGRWM GO:0005516 1/90 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8G4K65 GO:0016021 1/31 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SFCM0 GO:0005765 1/89 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG8SFCM0 GO:0031902 1/89 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8SFCM0 GO:0050797 1/89 thymidylate synthase (FAD) activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148] EOG8SFCM0 GO:0035280 1/89 miRNA loading onto RISC involved in gene silencing by miRNA biological_process "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438] EOG8SFCM0 GO:0031085 1/89 BLOC-3 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] EOG8SFCM0 GO:0070923 1/89 siRNA loading onto RISC involved in chromatin silencing by small RNA biological_process "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] EOG8SFCM0 GO:0060967 1/89 negative regulation of gene silencing by RNA biological_process "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] EOG87WR4B GO:0007264 23/82 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG87WR4B GO:0005525 23/82 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG87WR4B GO:0043025 1/82 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG87WR4B GO:0004767 1/82 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG85B3VQ GO:0003824 3/10 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG85B3VQ GO:0016788 1/10 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG85B3VQ GO:0016491 1/10 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG85B3VQ GO:0009058 1/10 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG83BQ3T GO:0005215 6/86 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG83BQ3T GO:0016020 4/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83BQ3T GO:0016021 2/86 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88D396 GO:0032440 2/117 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG88D396 GO:0008544 1/117 epidermis development biological_process "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] EOG88D396 GO:0035317 1/117 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG88D396 GO:0048477 1/117 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG88D396 GO:0045177 1/117 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG88D396 GO:0030725 1/117 germline ring canal formation biological_process "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] EOG88D396 GO:0016311 1/117 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG88D396 GO:0007560 1/117 imaginal disc morphogenesis biological_process "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] EOG88D396 GO:0017018 1/117 myosin phosphatase activity molecular_function "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] EOG88D396 GO:0048675 1/117 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG88D396 GO:0007391 1/117 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG88D396 GO:0045314 1/117 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG88D396 GO:0045179 1/117 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG83BQ3N GO:0006950 2/33 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG83BQ3K GO:0007165 25/97 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG83BQ3K GO:0005737 21/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ3K GO:0005622 4/97 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83BQ3K GO:0007480 1/97 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG83BQ3K GO:1900144 1/97 positive regulation of BMP secretion biological_process "Any process that activates or increases the frequency, rate or extent of BMP secretion." [GOC:sart, GOC:TermGenie] EOG83BQ3K GO:0031594 1/97 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG83BQ3K GO:0007274 1/97 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG83BQ3K GO:0005100 1/97 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG83BQ3K GO:0045887 1/97 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG83BQ3K GO:0043089 1/97 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG85B3VN GO:0016887 2/11 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG85B3VN GO:0005524 2/11 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85B3VN GO:0005215 1/11 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG85B3VN GO:0016020 1/11 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82587Q GO:0008289 19/93 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG83BQ3D GO:0003677 5/22 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85B3VD GO:0016021 37/82 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG85B3VD GO:0004930 36/82 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG85B3VD GO:0007218 28/82 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG85B3VD GO:0005886 12/82 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85B3VD GO:0007186 2/82 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG85B3VD GO:0030246 2/82 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG85B3VD GO:0007166 1/82 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG85B3VD GO:0006397 1/82 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG85B3VD GO:0003723 1/82 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG85B3VD GO:0005634 1/82 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85B3VD GO:0016020 1/82 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG85B3VD GO:0005737 1/82 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85B3VD GO:0004888 1/82 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8F20JW GO:0016021 38/62 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20JW GO:0006810 36/62 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8F20JW GO:0048193 2/62 Golgi vesicle transport biological_process "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] EOG8F20JW GO:0005215 2/62 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8F20JW GO:0005783 1/62 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8F20JW GO:0000003 1/62 reproduction biological_process "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] EOG8F20JW GO:0061357 1/62 positive regulation of Wnt protein secretion biological_process "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] EOG8F20JW GO:0090263 1/62 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG8F20JW GO:0048042 1/62 regulation of post-mating oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766] EOG8F20JW GO:0022008 1/62 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG87Q0M1 GO:0008270 1/63 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87Q0M1 GO:0004713 1/63 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG87Q0M1 GO:0016162 1/63 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG87Q0M1 GO:0005524 1/63 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87Q0M3 GO:0016021 25/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87Q0M3 GO:0004983 17/89 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG87Q0M3 GO:0004930 9/89 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG87Q0M3 GO:0007218 2/89 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG87Q0M3 GO:0050254 2/89 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG87Q0M3 GO:0008528 1/89 G-protein coupled peptide receptor activity molecular_function "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] EOG87Q0M3 GO:0008340 1/89 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG87Q0M3 GO:0008188 1/89 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG87Q0M3 GO:0007186 1/89 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG87Q0M3 GO:0005887 1/89 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z0DM8 GO:0050567 22/104 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG8Z0DM8 GO:0005524 22/104 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z0DM8 GO:0030956 22/104 glutamyl-tRNA(Gln) amidotransferase complex cellular_component "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] EOG8Z0DM8 GO:0032543 22/104 mitochondrial translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] EOG8Z0DM8 GO:0070681 22/104 glutaminyl-tRNAGln biosynthesis via transamidation biological_process "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] EOG8Z0DM8 GO:0005739 22/104 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Z0DM8 GO:0016884 8/104 carbon-nitrogen ligase activity, with glutamine as amido-N-donor molecular_function "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] EOG8Z0DM8 GO:0016740 1/104 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8G4K6Z GO:0004518 2/15 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8G4K6Z GO:0003677 2/15 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MPM5B GO:0051213 3/57 dioxygenase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] EOG8MPM5B GO:0048244 2/57 phytanoyl-CoA dioxygenase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068] EOG80KBDQ GO:0006535 1/9 cysteine biosynthetic process from serine biological_process "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] EOG80GG4N GO:0005524 35/162 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80GG4N GO:0016459 34/162 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG80GG4N GO:0003774 34/162 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG80GG4N GO:0004713 18/162 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG80GG4N GO:0004674 13/162 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG80GG4N GO:0004672 3/162 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG80GG4N GO:1990146 1/162 protein localization to rhabdomere biological_process "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687] EOG80GG4N GO:0005875 1/162 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG80GG4N GO:0005516 1/162 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG80GG4N GO:0007603 1/162 phototransduction, visible light biological_process "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG80GG4N GO:0007010 1/162 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG80GG4N GO:0016028 1/162 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG80GG4N GO:0004702 1/162 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG80GG4N GO:0007601 1/162 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG80GG4N GO:0005737 1/162 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80GG4N GO:0033227 1/162 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG80GG4N GO:0042385 1/162 myosin III complex cellular_component "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG80GG4N GO:0006200 1/162 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG80GG4N GO:0006886 1/162 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG80GG4N GO:0009416 1/162 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG80GG4N GO:0016027 1/162 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG80GG4N GO:0035091 1/162 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG80GG4N GO:0006468 1/162 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG80GG4N GO:0016461 1/162 unconventional myosin complex cellular_component "A portmanteau term for myosins other than myosin II." [GOC:ma] EOG80GG4N GO:0016062 1/162 adaptation of rhodopsin mediated signaling biological_process "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] EOG80GG4N GO:0042623 1/162 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG80GG4N GO:0045494 1/162 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG80GG4N GO:0005198 1/162 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG80GG4N GO:0007155 1/162 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG80GG4N GO:0008104 1/162 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG80GG4N GO:0016059 1/162 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG80GG4N GO:0023014 1/162 signal transduction by protein phosphorylation biological_process "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] EOG8CC6GM GO:0004844 5/23 uracil DNA N-glycosylase activity molecular_function "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623] EOG8CC6GM GO:0006284 5/23 base-excision repair biological_process "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] EOG8CC6GM GO:0005739 5/23 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8CC6GM GO:0005634 5/23 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8MPM5T GO:0016021 2/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MPM5T GO:0004937 1/9 alpha1-adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] EOG8MPM5T GO:0005886 1/9 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MPM5T GO:0004935 1/9 adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] EOG8MPM5T GO:0055117 1/9 regulation of cardiac muscle contraction biological_process "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] EOG8MPM5T GO:0019229 1/9 regulation of vasoconstriction biological_process "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] EOG80KBDB GO:0016746 22/105 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG80KBDB GO:0004095 3/105 carnitine O-palmitoyltransferase activity molecular_function "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] EOG80KBDB GO:0003993 1/105 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG80KBDB GO:0006979 1/105 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG80KBDB GO:0010038 1/105 response to metal ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] EOG80KBDB GO:0042594 1/105 response to starvation biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] EOG8NW228 GO:0016020 6/64 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NW228 GO:0007157 2/64 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8V71WK GO:0004930 7/22 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8V71WK GO:0016021 7/22 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V71WK GO:0005886 7/22 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PG8DV GO:0004842 27/103 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8PG8DV GO:0016874 1/103 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8PG8DV GO:0005737 1/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PG8DV GO:0016740 1/103 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8PG8DV GO:0042787 1/103 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG8PG8DV GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG805VF3 GO:0005634 6/60 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG805VF3 GO:0008270 6/60 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG805VF3 GO:0003700 6/60 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG805VF3 GO:0003964 1/60 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG805VF3 GO:0003723 1/60 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG805VF2 GO:0016236 1/101 macroautophagy biological_process "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] EOG805VF2 GO:0006914 1/101 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG805VF2 GO:0034273 1/101 ATG1/UKL1 kinase complex cellular_component "A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598] EOG8R268B GO:0016021 28/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R268B GO:0004930 26/103 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8R268B GO:0008188 1/103 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8R268B GO:0007186 1/103 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8R268B GO:0007218 1/103 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8JT2NK GO:0003998 88/203 acylphosphatase activity molecular_function "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] EOG8JT2NK GO:0008152 5/203 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8JT2NK GO:0005737 2/203 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JT2NK GO:0044237 1/203 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8JT2NK GO:0016787 1/203 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8W3W45 GO:0006355 1/8 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8W3W45 GO:0003677 1/8 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8W3W45 GO:0000156 1/8 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8DBWXS GO:0022008 1/101 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG805VFZ GO:2000060 1/65 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF] EOG805VFZ GO:0032093 1/65 SAM domain binding molecular_function "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] EOG805VFZ GO:0031647 1/65 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8G1Q06 GO:0006457 1/105 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG805VFK GO:0006397 25/94 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG805VFK GO:0016788 23/94 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG805VFK GO:0090502 2/94 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG805VFK GO:0008419 2/94 RNA lariat debranching enzyme activity molecular_function "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612] EOG805VFK GO:0000375 2/94 RNA splicing, via transesterification reactions biological_process "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] EOG805VFK GO:0005634 2/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG805VFK GO:0005524 1/94 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG805VFK GO:0003968 1/94 RNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] EOG805VFK GO:0017111 1/94 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG805VFK GO:0006396 1/94 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG80KBD8 GO:0003676 2/43 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80KBD8 GO:0008270 2/43 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VX4KS GO:0046872 11/348 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VX4KS GO:0005737 1/348 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8VX4KS GO:0010629 1/348 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8VX4KS GO:0042826 1/348 histone deacetylase binding molecular_function "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] EOG8VX4KS GO:0005634 1/348 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87Q0MC GO:0046872 20/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG879HN4 GO:0005524 26/98 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG879HN4 GO:0004823 26/98 leucine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691] EOG879HN4 GO:0006429 26/98 leucyl-tRNA aminoacylation biological_process "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG879HN4 GO:0002161 24/98 aminoacyl-tRNA editing activity molecular_function "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] EOG879HN5 GO:0005506 116/248 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG879HN5 GO:0020037 116/248 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG879HN5 GO:0016705 114/248 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG879HN5 GO:0004497 107/248 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG879HN5 GO:0031966 7/248 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG879HN5 GO:0017085 3/248 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG879HN5 GO:0008386 2/248 cholesterol monooxygenase (side-chain-cleaving) activity molecular_function "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] EOG879HN5 GO:0046680 2/248 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG879HN5 GO:0005739 1/248 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG879HN5 GO:0030342 1/248 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity molecular_function "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] EOG879HN5 GO:0055114 1/248 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG879HN6 GO:0016021 18/74 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HN6 GO:0007523 1/74 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG879HN6 GO:0006869 1/74 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG879HN6 GO:0005737 1/74 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG879HN6 GO:0048471 1/74 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG879HN6 GO:0006200 1/74 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG879HN6 GO:0061024 1/74 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG879HN6 GO:0005811 1/74 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG879HN6 GO:0031887 1/74 lipid particle transport along microtubule biological_process "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895] EOG879HN6 GO:0035149 1/74 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG879HN6 GO:0030286 1/74 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG879HN6 GO:0035239 1/74 tube morphogenesis biological_process "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] EOG879HN6 GO:0001745 1/74 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG879HN6 GO:0005881 1/74 cytoplasmic microtubule cellular_component "Any microtubule in the cytoplasm of a cell." [GOC:mah] EOG879HN6 GO:0005515 1/74 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG879HN6 GO:0051640 1/74 organelle localization biological_process "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] EOG879HN6 GO:0060361 1/74 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG879HN6 GO:0007018 1/74 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG879HN6 GO:0042623 1/74 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG879HN6 GO:0007097 1/74 nuclear migration biological_process "The directed movement of the nucleus." [GOC:ai] EOG879HN6 GO:0040011 1/74 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG879HN6 GO:0042051 1/74 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG879HN6 GO:0005635 1/74 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG8MPM52 GO:0030170 3/8 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8MPM52 GO:0008483 2/8 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8MPM52 GO:0009102 1/8 biotin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] EOG8MPM52 GO:0004015 1/8 adenosylmethionine-8-amino-7-oxononanoate transaminase activity molecular_function "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864] EOG8MPM52 GO:0016021 1/8 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87Q0MH GO:0005524 37/124 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87Q0MH GO:0004674 33/124 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG87Q0MH GO:0004683 3/124 calmodulin-dependent protein kinase activity molecular_function "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] EOG87Q0MH GO:0004672 2/124 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG87Q0MH GO:0006468 1/124 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb]