Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00001 PF13660 PF05161 1 0 0 0 0 0 PF00001 PF15393 1 0 0 0 0 0 PF00002 0 1 0 0 0 0 PF00004 PF01728 PF11861 PF07780 1 0 0 0 0 0 PF00004 PF10199 1 0 0 0 0 0 PF00005 PF01061 PF00005 PF01061 1 0 0 0 0 0 PF00008 PF07645 1 0 0 0 0 0 PF00008 PF07645 PF00008 0 0 2 0 0 0 PF00009 0 1 0 0 0 0 PF00009 PF03144 PF14492 0 1 2 0 0 0 PF00009 PF03144 PF14492 PF03764 0 1 0 0 0 0 PF00010 PF01454 1 0 0 0 0 0 PF00010 PF16019 1 0 0 0 0 0 PF00013 PF12235 0 0 1 0 0 0 PF00017 PF08416 1 0 0 0 0 0 PF00018 0 1 0 0 0 0 PF00018 PF00017 PF07714 PF00795 1 0 0 0 0 0 PF00018 PF00621 PF00169 1 0 0 0 0 0 PF00019 0 1 0 0 0 0 PF00023 0 1 3 0 0 0 PF00028 PF00059 1 0 0 0 0 0 PF00035 PF16482 PF05018 1 0 0 0 0 0 PF00043 PF09334 PF00458 1 0 0 0 0 0 PF00046 PF00416 1 0 0 0 0 0 PF00046 PF00656 1 0 0 0 0 0 PF00047 PF07679 PF13927 PF07679 PF07714 1 0 0 0 0 0 PF00051 PF07714 0 1 1 0 0 0 PF00055 PF00053 PF00052 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0 0 0 0 1 0 PF02330 PF00160 1 0 0 0 0 0 PF02338 0 1 0 0 0 0 PF02338 PF14465 1 0 0 0 0 0 PF02493 PF03765 PF00650 1 0 0 0 0 0 PF02545 PF14852 PF14853 1 0 0 0 0 0 PF02733 PF02734 PF00160 1 0 0 0 0 0 PF02736 PF00063 0 0 2 0 0 0 PF02750 0 0 1 0 0 0 PF02752 0 0 1 0 0 0 PF02761 PF02762 PF14447 PF00627 0 0 1 0 0 0 PF02786 PF02785 PF00364 0 0 1 0 0 0 PF02793 PF00002 PF08395 1 0 0 0 0 0 PF02803 PF02036 0 1 0 0 0 0 PF02819 0 0 0 0 1 0 PF02820 PF12140 PF13927 PF07679 PF00041 PF13882 1 0 0 0 0 0 PF02866 PF10058 1 0 0 0 0 0 PF02931 PF02932 PF00160 1 0 0 0 0 0 PF02931 PF02932 PF06979 1 0 0 0 0 0 PF02933 PF00004 0 0 1 0 0 0 PF02934 0 0 1 0 0 0 PF02949 PF01180 1 0 0 0 0 0 PF02949 PF07690 1 0 0 0 0 0 PF02969 PF07571 PF02182 1 0 0 0 0 0 PF03097 PF00595 1 0 5 0 0 0 PF03121 0 0 0 0 1 0 PF03144 PF03143 0 1 2 0 0 0 PF03248 0 0 0 0 1 0 PF03297 0 0 0 0 1 0 PF03453 PF00994 PF03454 0 0 1 0 0 0 PF03522 0 1 0 0 0 0 PF03671 0 0 0 0 1 0 PF03725 0 1 0 0 0 0 PF03803 PF00106 1 0 0 0 0 0 PF03810 0 1 0 0 0 0 PF03853 PF00160 1 0 0 0 0 0 PF03876 0 1 1 0 0 0 PF03937 0 0 0 0 1 0 PF03946 0 0 1 0 0 0 PF04000 PF01583 PF14306 PF01747 1 0 0 0 0 0 PF04045 PF16038 1 0 0 0 0 0 PF04055 PF01938 0 1 0 0 0 0 PF04083 PF00996 1 0 0 0 0 0 PF04104 PF00076 1 0 0 0 0 0 PF04188 0 0 0 0 1 0 PF04379 0 0 0 0 1 0 PF04434 0 0 0 0 1 0 PF04565 PF06883 PF00562 PF04560 0 0 1 0 0 0 PF04627 0 0 0 0 1 0 PF04628 PF02434 1 0 0 0 0 0 PF04670 PF00484 1 0 0 0 0 0 PF04675 PF01068 0 0 1 0 0 0 PF04677 0 0 1 0 0 0 PF04678 PF14778 1 0 0 0 0 0 PF04712 PF01138 1 0 0 0 0 0 PF04719 PF00090 1 0 0 0 0 0 PF04752 0 0 0 0 1 0 PF04818 0 1 2 0 0 0 PF04851 PF13086 PF13087 0 0 1 0 0 0 PF04898 0 0 4 0 0 0 PF04908 0 0 0 0 1 0 PF04928 0 0 1 0 0 0 PF04979 PF03357 1 0 0 0 0 0 PF05005 0 0 0 0 1 0 PF05148 0 0 0 0 1 0 PF05224 PF13884 PF13887 PF13888 PF00160 1 0 0 0 0 0 PF05283 0 0 0 0 1 0 PF05383 0 1 0 0 0 0 PF05593 0 0 1 0 0 0 PF05622 PF04904 PF04905 1 0 0 0 0 0 PF05741 PF00089 1 0 0 0 0 0 PF05821 PF00160 1 0 0 0 0 0 PF05934 0 0 0 0 1 0 PF06027 0 0 0 0 1 0 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0 0 PF08073 PF00628 PF00385 PF00176 PF00271 PF06465 PF06461 PF08074 PF00675 PF05193 PF16187 PF05193 1 0 0 0 0 0 PF08123 PF01562 PF13574 1 0 0 0 0 0 PF08144 0 0 0 0 1 0 PF08159 PF00628 1 0 0 0 0 0 PF08205 PF07679 PF13927 1 0 0 0 0 0 PF08205 PF13927 PF00041 1 0 0 0 0 0 PF08257 0 0 0 0 1 0 PF08318 0 0 1 0 0 0 PF08332 0 1 0 0 0 0 PF08351 PF05127 PF13718 0 0 1 0 0 0 PF08393 PF12774 0 0 11 0 0 0 PF08412 0 1 0 0 0 0 PF08449 PF01699 1 0 0 0 0 0 PF08515 PF07714 0 0 1 0 0 0 PF08609 0 0 0 0 1 0 PF08617 0 0 0 0 1 0 PF08790 0 0 0 0 1 0 PF08828 0 1 0 0 0 0 PF08938 0 0 0 0 1 0 PF08953 PF00400 PF16300 PF08953 PF00400 PF16300 1 0 0 0 0 0 PF08991 0 0 0 0 1 0 PF08997 0 0 0 0 1 0 PF09177 0 0 0 0 1 0 PF09279 PF00388 0 0 5 0 0 0 PF09311 PF01363 0 0 1 0 0 0 PF09325 0 1 0 0 0 0 PF09350 0 1 0 0 0 0 PF09379 0 1 15 0 0 0 PF09380 0 1 3 0 0 0 PF09429 PF00035 1 0 0 0 0 0 PF09431 0 1 0 0 0 0 PF09445 0 0 0 0 1 0 PF09469 0 0 0 0 1 0 PF09765 PF11793 PF07690 1 0 0 0 0 0 PF09803 0 0 0 0 1 0 PF09805 0 0 0 0 1 0 PF09807 0 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PF00612 1 0 0 0 0 0 PF12861 0 0 0 0 1 0 PF12874 PF02824 PF07973 PF00587 PF03129 1 0 0 0 0 0 PF12925 PF10515 0 1 0 0 0 0 PF12937 PF00071 1 0 0 0 0 0 PF13181 0 1 0 0 0 0 PF13181 PF13432 0 0 3 0 0 0 PF13181 PF13877 1 0 0 0 0 0 PF13412 PF03103 1 0 0 0 0 0 PF13415 0 1 4 0 0 0 PF13418 PF13415 0 0 2 0 0 0 PF13432 0 1 4 0 0 0 PF13432 PF13181 PF01826 1 0 0 0 0 0 PF13499 PF13202 PF00160 1 0 0 0 0 0 PF13499 PF13833 PF13499 1 0 0 0 0 0 PF13513 0 1 0 0 0 0 PF13520 PF07778 1 0 0 0 0 0 PF13589 0 1 0 0 0 0 PF13621 PF00025 1 0 0 0 0 0 PF13637 PF12796 PF13637 1 0 0 0 0 0 PF13639 PF12906 1 0 0 0 0 0 PF13688 0 0 1 0 0 0 PF13688 PF00200 PF16698 0 1 0 0 0 0 PF13718 PF13725 0 0 2 0 0 0 PF13854 PF13415 0 1 0 0 0 0 PF13855 0 1 0 0 0 0 PF13855 PF00560 PF13855 PF01582 1 0 0 0 0 0 PF13855 PF00560 PF13855 PF13306 1 0 0 0 0 0 PF13863 0 0 0 0 1 0 PF13879 PF00160 1 0 0 0 0 0 PF13894 PF12874 PF13912 1 0 0 0 0 0 PF13904 0 0 0 0 1 0 PF13912 PF12874 1 0 0 0 0 0 PF13912 PF13894 PF12874 0 1 0 0 0 0 PF13913 PF00009 PF03144 PF14492 PF03764 PF00679 1 0 0 0 0 0 PF13913 PF03901 1 0 0 0 0 0 PF13923 0 2 0 0 0 0 PF13923 PF02037 1 0 0 0 0 0 PF13923 PF16207 PF13923 PF16207 1 0 0 0 0 0 PF13927 PF00041 1 0 11 0 0 0 PF13927 PF00656 PF00467 PF17136 1 0 0 0 0 0 PF13927 PF07679 PF00017 PF00018 PF00017 PF00169 PF00168 PF00616 1 0 0 0 0 0 PF14051 0 1 0 0 0 0 PF14160 PF01363 1 0 0 0 0 0 PF14551 PF17207 PF00493 PF01153 1 0 0 0 0 0 PF14580 PF10188 1 0 0 0 0 0 PF14604 PF00226 1 0 0 0 0 0 PF14646 0 0 0 0 1 0 PF14691 PF07992 PF01180 PF14697 PF00160 1 0 0 0 0 0 PF14694 PF14695 PF10239 1 0 0 0 0 0 PF14770 0 0 0 0 1 0 PF14774 0 0 0 0 1 0 PF14777 0 0 0 0 1 0 PF14813 0 0 0 0 1 0 PF14844 PF02138 PF00400 1 0 0 0 0 0 PF14916 0 0 0 0 1 0 PF14935 0 0 0 0 1 0 PF14952 PF01849 1 0 0 0 0 0 PF14977 0 0 0 0 1 0 PF15011 PF00209 1 0 0 0 0 0 PF15031 0 0 0 0 1 0 PF15055 0 0 0 0 1 0 PF15266 0 0 0 0 1 0 PF15295 0 0 0 0 1 0 PF15309 PF00685 1 0 0 0 0 0 PF15320 0 0 0 0 1 0 PF15433 0 0 0 0 1 0 PF15454 0 0 0 0 1 0 PF15469 0 1 0 0 0 0 PF15663 PF00642 1 0 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