GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0016491	oxidoreductase activity	Gains
GO:0048037	cofactor binding	Gains
GO:0003824	catalytic activity	Gains
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Gains
GO:0036094	small molecule binding	Gains
GO:0016829	lyase activity	Gains
GO:0043168	anion binding	Gains
GO:0050662	coenzyme binding	Gains
GO:0000156	phosphorelay response regulator activity	Gains
GO:0017111	nucleoside-triphosphatase activity	Gains
GO:0017076	purine nucleotide binding	Gains
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Gains
GO:0019842	vitamin binding	Gains
GO:0032553	ribonucleotide binding	Gains
GO:0000166	nucleotide binding	Gains
GO:1901265	nucleoside phosphate binding	Gains
GO:0016462	pyrophosphatase activity	Gains
GO:0050660	flavin adenine dinucleotide binding	Gains
GO:0030554	adenyl nucleotide binding	Gains
GO:0016817	hydrolase activity, acting on acid anhydrides	Gains
GO:0032555	purine ribonucleotide binding	Gains
GO:0005215	transporter activity	Gains
GO:0035639	purine ribonucleoside triphosphate binding	Gains
GO:0005524	ATP binding	Gains
GO:0032559	adenyl ribonucleotide binding	Gains
GO:0097367	carbohydrate derivative binding	Gains
GO:0016887	ATPase activity	Gains
GO:0016849	phosphorus-oxygen lyase activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0003883	CTP synthase activity	Gains
GO:0004148	dihydrolipoyl dehydrogenase activity	Gains
GO:0016151	nickel cation binding	Gains
GO:0004896	cytokine receptor activity	Gains
GO:0016743	carboxyl- or carbamoyltransferase activity	Gains
GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
GO:0004617	phosphoglycerate dehydrogenase activity	Gains
GO:0004070	aspartate carbamoyltransferase activity	Gains
GO:0030170	pyridoxal phosphate binding	Gains
GO:0070279	vitamin B6 binding	Gains
GO:0042910	xenobiotic transmembrane transporter activity	Gains
GO:0003993	acid phosphatase activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004872	receptor activity	Gains
GO:0016836	hydro-lyase activity	Gains
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
GO:0005452	inorganic anion exchanger activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0008483	transaminase activity	Gains
GO:0004866	endopeptidase inhibitor activity	Gains
GO:0016769	transferase activity, transferring nitrogenous groups	Gains
GO:0008028	monocarboxylic acid transmembrane transporter activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0022804	active transmembrane transporter activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0016835	carbon-oxygen lyase activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	Gains
GO:0004658	propionyl-CoA carboxylase activity	Gains
GO:0016841	ammonia-lyase activity	Gains
GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
GO:0003995	acyl-CoA dehydrogenase activity	Gains
GO:0043492	ATPase activity, coupled to movement of substances	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
GO:0016840	carbon-nitrogen lyase activity	Gains
GO:0015929	hexosaminidase activity	Gains
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Gains
GO:0004089	carbonate dehydratase activity	Gains
GO:0015103	inorganic anion transmembrane transporter activity	Gains
GO:0033218	amide binding	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0031406	carboxylic acid binding	Gains
GO:0043177	organic acid binding	Gains
GO:0000155	phosphorelay sensor kinase activity	Gains
GO:0004673	protein histidine kinase activity	Gains
GO:0008460	dTDP-glucose 4,6-dehydratase activity	Gains
GO:0008475	procollagen-lysine 5-dioxygenase activity	Gains
GO:0004372	glycine hydroxymethyltransferase activity	Gains
GO:0016416	O-palmitoyltransferase activity	Gains
GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	Gains
GO:0016406	carnitine O-acyltransferase activity	Gains
GO:0008658	penicillin binding	Gains
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	Gains
GO:0004637	phosphoribosylamine-glycine ligase activity	Gains
GO:0009039	urease activity	Gains
GO:0004095	carnitine O-palmitoyltransferase activity	Gains
GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
GO:0004995	tachykinin receptor activity	Gains
GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Gains
GO:0004044	amidophosphoribosyltransferase activity	Gains
GO:0004950	chemokine receptor activity	Gains
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Gains
GO:0009055	electron transfer activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0022836	gated channel activity	Gains
GO:0004300	enoyl-CoA hydratase activity	Gains
GO:0003676	nucleic acid binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0046914	transition metal ion binding	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0003677	DNA binding	Losses
GO:0015631	tubulin binding	Losses
GO:0031409	pigment binding	Losses
GO:0043015	gamma-tubulin binding	Losses
GO:0046872	metal ion binding	Losses
GO:0008047	enzyme activator activity	Losses
GO:0043169	cation binding	Losses
GO:0008234	cysteine-type peptidase activity	Losses
GO:0008017	microtubule binding	Losses
GO:0101005	ubiquitinyl hydrolase activity	Losses
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
GO:0019783	ubiquitin-like protein-specific protease activity	Losses
GO:0051020	GTPase binding	Losses
GO:0017016	Ras GTPase binding	Losses
GO:0060589	nucleoside-triphosphatase regulator activity	Losses
GO:0008190	eukaryotic initiation factor 4E binding	Losses
GO:0005549	odorant binding	Losses
GO:0031267	small GTPase binding	Losses
GO:0004803	transposase activity	Losses
GO:0030695	GTPase regulator activity	Losses
GO:0008066	glutamate receptor activity	Losses
GO:0030246	carbohydrate binding	Losses
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
GO:0036081	extracellular ammonia-gated ion channel activity	Losses
GO:0005085	guanyl-nucleotide exchange factor activity	Losses
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GO:0005096	GTPase activator activity	Losses
GO:0022824	transmitter-gated ion channel activity	Losses
GO:0022835	transmitter-gated channel activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0004970	ionotropic glutamate receptor activity	Losses
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	Losses
GO:0019840	isoprenoid binding	Losses
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
GO:0005319	lipid transporter activity	Losses
GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0008233	peptidase activity	Losses
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	Losses
GO:0061133	endopeptidase activator activity	Losses
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Losses
GO:0051032	nucleic acid transmembrane transporter activity	Losses
GO:0051033	RNA transmembrane transporter activity	Losses
GO:0043874	acireductone synthase activity	Losses
GO:0030546	receptor activator activity	Losses
GO:0004555	alpha,alpha-trehalase activity	Losses
GO:0005500	juvenile hormone binding	Losses
GO:0008967	phosphoglycolate phosphatase activity	Losses
GO:0015927	trehalase activity	Losses
GO:0050591	quinine 3-monooxygenase activity	Losses
GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
GO:0005488	binding	Losses
GO:0003676	nucleic acid binding	Extinctions
GO:0015631	tubulin binding	Extinctions
GO:0008047	enzyme activator activity	Extinctions
GO:0008234	cysteine-type peptidase activity	Extinctions
GO:0008017	microtubule binding	Extinctions
GO:0008190	eukaryotic initiation factor 4E binding	Extinctions
GO:0005272	sodium channel activity	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0060589	nucleoside-triphosphatase regulator activity	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
GO:0017016	Ras GTPase binding	Extinctions
GO:0008066	glutamate receptor activity	Extinctions
GO:0031267	small GTPase binding	Extinctions
GO:0004197	cysteine-type endopeptidase activity	Extinctions
GO:0030695	GTPase regulator activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:0031409	pigment binding	Extinctions
GO:0019840	isoprenoid binding	Extinctions
GO:0043015	gamma-tubulin binding	Extinctions
GO:0051020	GTPase binding	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
GO:0022824	transmitter-gated ion channel activity	Extinctions
GO:0022835	transmitter-gated channel activity	Extinctions
GO:0004970	ionotropic glutamate receptor activity	Extinctions
GO:0008289	lipid binding	Extinctions
GO:0061133	endopeptidase activator activity	Extinctions
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Extinctions
GO:0030546	receptor activator activity	Extinctions
GO:0005500	juvenile hormone binding	Extinctions
GO:0008967	phosphoglycolate phosphatase activity	Extinctions
GO:0005096	GTPase activator activity	Extinctions
GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
GO:0017137	Rab GTPase binding	Extinctions
GO:0003743	translation initiation factor activity	Extinctions
GO:0008199	ferric iron binding	Extinctions
GO:0046872	metal ion binding	Extinctions
GO:0030246	carbohydrate binding	Extinctions
GO:0061135	endopeptidase regulator activity	Extinctions
GO:0043169	cation binding	Extinctions