GO:0015238	drug transmembrane transporter activity	Gains
GO:0090484	drug transporter activity	Gains
GO:0005319	lipid transporter activity	Gains
GO:0003777	microtubule motor activity	Gains
GO:0003774	motor activity	Gains
GO:0004305	ethanolamine kinase activity	Gains
GO:0004103	choline kinase activity	Gains
GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
GO:0008559	xenobiotic transmembrane transporting ATPase activity	Gains
GO:0005524	ATP binding	Gains
GO:0032559	adenyl ribonucleotide binding	Gains
GO:0016787	hydrolase activity	Gains
GO:0016798	hydrolase activity, acting on glycosyl bonds	Gains
GO:0042910	xenobiotic transmembrane transporter activity	Gains
GO:0016301	kinase activity	Gains
GO:0030554	adenyl nucleotide binding	Gains
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Gains
GO:0022804	active transmembrane transporter activity	Gains
GO:0003824	catalytic activity	Gains
GO:0004674	protein serine/threonine kinase activity	Gains
GO:0015101	organic cation transmembrane transporter activity	Gains
GO:0050308	sugar-phosphatase activity	Gains
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
GO:0003993	acid phosphatase activity	Gains
GO:0042623	ATPase activity, coupled	Gains
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
GO:0005452	inorganic anion exchanger activity	Gains
GO:0019200	carbohydrate kinase activity	Gains
GO:0005548	phospholipid transporter activity	Gains
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Gains
GO:0043168	anion binding	Gains
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Gains
GO:0043492	ATPase activity, coupled to movement of substances	Gains
GO:0035639	purine ribonucleoside triphosphate binding	Gains
GO:0032555	purine ribonucleotide binding	Gains
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Gains
GO:0015399	primary active transmembrane transporter activity	Gains
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Gains
GO:0016887	ATPase activity	Gains
GO:0005313	L-glutamate transmembrane transporter activity	Gains
GO:0008307	structural constituent of muscle	Gains
GO:0004012	phospholipid-translocating ATPase activity	Gains
GO:0008859	exoribonuclease II activity	Gains
GO:0019203	carbohydrate phosphatase activity	Gains
GO:0015172	acidic amino acid transmembrane transporter activity	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0016307	phosphatidylinositol phosphate kinase activity	Gains
GO:0005509	calcium ion binding	Gains
GO:0016791	phosphatase activity	Gains
GO:0005215	transporter activity	Gains
GO:0017076	purine nucleotide binding	Gains
GO:0097367	carbohydrate derivative binding	Gains
GO:0032553	ribonucleotide binding	Gains
GO:0004312	fatty acid synthase activity	Gains
GO:0015179	L-amino acid transmembrane transporter activity	Gains
GO:0005086	ARF guanyl-nucleotide exchange factor activity	Gains
GO:0004687	myosin light chain kinase activity	Gains
GO:0036094	small molecule binding	Gains
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Gains
GO:0008484	sulfuric ester hydrolase activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0008017	microtubule binding	Gains
GO:0005096	GTPase activator activity	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0008349	MAP kinase kinase kinase kinase activity	Gains
GO:0008331	high voltage-gated calcium channel activity	Gains
GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	Gains
GO:0046624	sphingolipid transporter activity	Gains
GO:0046625	sphingolipid binding	Gains
GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Gains
GO:0015619	thiamine pyrophosphate-transporting ATPase activity	Gains
GO:0016231	beta-N-acetylglucosaminidase activity	Gains
GO:0140033	acetylation-dependent protein binding	Gains
GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	Gains
GO:0016785	transferase activity, transferring selenium-containing groups	Gains
GO:0005436	sodium:phosphate symporter activity	Gains
GO:0047886	farnesol dehydrogenase activity	Gains
GO:0050564	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity	Gains
GO:0042806	fucose binding	Gains
GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	Gains
GO:0004396	hexokinase activity	Gains
GO:0017128	phospholipid scramblase activity	Gains
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	Gains
GO:0045174	glutathione dehydrogenase (ascorbate) activity	Gains
GO:0008798	beta-aspartyl-peptidase activity	Gains
GO:0045118	azole transporter activity	Gains
GO:0019158	mannokinase activity	Gains
GO:0031434	mitogen-activated protein kinase kinase binding	Gains
GO:0004340	glucokinase activity	Gains
GO:0004346	glucose-6-phosphatase activity	Gains
GO:0042656	JUN kinase kinase kinase kinase activity	Gains
GO:0004301	epoxide hydrolase activity	Gains
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	Gains
GO:0004454	ketohexokinase activity	Gains
GO:0016648	oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor	Gains
GO:0004476	mannose-6-phosphate isomerase activity	Gains
GO:0003872	6-phosphofructokinase activity	Gains
GO:0008865	fructokinase activity	Gains
GO:0035529	NADH pyrophosphatase activity	Gains
GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Gains
GO:0008800	beta-lactamase activity	Gains
GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Gains
GO:0035620	ceramide transporter activity	Gains
GO:1901474	azole transmembrane transporter activity	Gains
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Gains
GO:0047964	glyoxylate reductase activity	Gains
GO:0051183	vitamin transporter activity	Gains
GO:0033041	sweet taste receptor activity	Gains
GO:0004734	pyrimidodiazepine synthase activity	Gains
GO:0070577	lysine-acetylated histone binding	Gains
GO:0097001	ceramide binding	Gains
GO:0050357	tropinesterase activity	Gains
GO:0008093	cytoskeletal adaptor activity	Gains
GO:0015234	thiamine transmembrane transporter activity	Gains
GO:0030267	glyoxylate reductase (NADP) activity	Gains
GO:0004802	transketolase activity	Gains
GO:0050309	sugar-terminal-phosphatase activity	Gains
GO:0004561	alpha-N-acetylglucosaminidase activity	Gains
GO:0004567	beta-mannosidase activity	Gains
GO:0004556	alpha-amylase activity	Gains
GO:0004528	phosphodiesterase I activity	Gains
GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	Gains
GO:0008927	mannonate dehydratase activity	Gains
GO:0004679	AMP-activated protein kinase activity	Gains
GO:0004611	phosphoenolpyruvate carboxykinase activity	Gains
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Gains
GO:0050112	inositol 2-dehydrogenase activity	Gains
GO:0047407	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	Gains
GO:0090482	vitamin transmembrane transporter activity	Gains
GO:0090422	thiamine pyrophosphate transporter activity	Gains
GO:0016160	amylase activity	Gains
GO:0050291	sphingosine N-acyltransferase activity	Gains
GO:0015562	efflux transmembrane transporter activity	Gains
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	Gains
GO:0050221	prostaglandin-E2 9-reductase activity	Gains
GO:0005214	structural constituent of chitin-based cuticle	Gains
GO:0005310	dicarboxylic acid transmembrane transporter activity	Gains
GO:0015296	anion:cation symporter activity	Gains
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	Gains
GO:0015631	tubulin binding	Gains
GO:0016788	hydrolase activity, acting on ester bonds	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004518	nuclease activity	Losses
GO:0003676	nucleic acid binding	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0004519	endonuclease activity	Losses
GO:0004812	aminoacyl-tRNA ligase activity	Losses
GO:0140098	catalytic activity, acting on RNA	Losses
GO:0003677	DNA binding	Losses
GO:0046914	transition metal ion binding	Losses
GO:0140101	catalytic activity, acting on a tRNA	Losses
GO:0015081	sodium ion transmembrane transporter activity	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0004075	biotin carboxylase activity	Losses
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
GO:0038023	signaling receptor activity	Losses
GO:0004983	neuropeptide Y receptor activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0005249	voltage-gated potassium channel activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0004450	isocitrate dehydrogenase (NADP+) activity	Losses
GO:0004736	pyruvate carboxylase activity	Losses
GO:0004823	leucine-tRNA ligase activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0016885	ligase activity, forming carbon-carbon bonds	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0004540	ribonuclease activity	Losses
GO:0004000	adenosine deaminase activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0043167	ion binding	Losses
GO:0005328	neurotransmitter:sodium symporter activity	Losses
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	Losses
GO:0004828	serine-tRNA ligase activity	Losses
GO:0004658	propionyl-CoA carboxylase activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Losses
GO:0004872	receptor activity	Losses
GO:0009055	electron transfer activity	Losses
GO:0050662	coenzyme binding	Losses
GO:0000155	phosphorelay sensor kinase activity	Losses
GO:0004673	protein histidine kinase activity	Losses
GO:0005507	copper ion binding	Losses
GO:0019239	deaminase activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0048037	cofactor binding	Losses
GO:0043169	cation binding	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0016215	acyl-CoA desaturase activity	Losses
GO:0005451	monovalent cation:proton antiporter activity	Losses
GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	Losses
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Losses
GO:0004768	stearoyl-CoA 9-desaturase activity	Losses
GO:0004818	glutamate-tRNA ligase activity	Losses
GO:0005326	neurotransmitter transporter activity	Losses
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0046872	metal ion binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0005244	voltage-gated ion channel activity	Losses
GO:0022832	voltage-gated channel activity	Losses
GO:0019205	nucleobase-containing compound kinase activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0005488	binding	Losses
GO:0022843	voltage-gated cation channel activity	Losses
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
GO:0043565	sequence-specific DNA binding	Losses
GO:0030145	manganese ion binding	Losses
GO:0005506	iron ion binding	Losses
GO:0004871	signal transducer activity	Losses
GO:0004448	isocitrate dehydrogenase activity	Losses
GO:0015299	solute:proton antiporter activity	Losses
GO:0004813	alanine-tRNA ligase activity	Losses
GO:0002161	aminoacyl-tRNA editing activity	Losses
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0004812	aminoacyl-tRNA ligase activity	Extinctions
GO:0140101	catalytic activity, acting on a tRNA	Extinctions
GO:0004000	adenosine deaminase activity	Extinctions
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	Extinctions
GO:0019239	deaminase activity	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0004450	isocitrate dehydrogenase (NADP+) activity	Extinctions
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Extinctions
GO:0005507	copper ion binding	Extinctions
GO:0140098	catalytic activity, acting on RNA	Extinctions
GO:0004828	serine-tRNA ligase activity	Extinctions
GO:0004658	propionyl-CoA carboxylase activity	Extinctions
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Extinctions
GO:0004818	glutamate-tRNA ligase activity	Extinctions
GO:0016885	ligase activity, forming carbon-carbon bonds	Extinctions
GO:0004075	biotin carboxylase activity	Extinctions
GO:0004448	isocitrate dehydrogenase activity	Extinctions
GO:0004813	alanine-tRNA ligase activity	Extinctions
GO:0016491	oxidoreductase activity	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Extinctions
GO:0070330	aromatase activity	Extinctions
GO:0016615	malate dehydrogenase activity	Extinctions
GO:0019205	nucleobase-containing compound kinase activity	Extinctions
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Extinctions
GO:0005506	iron ion binding	Extinctions
GO:0004518	nuclease activity	Extinctions
GO:0015002	heme-copper terminal oxidase activity	Extinctions
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
GO:0004129	cytochrome-c oxidase activity	Extinctions
GO:0003960	NADPH:quinone reductase activity	Extinctions
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Extinctions
GO:0050136	NADH dehydrogenase (quinone) activity	Extinctions
GO:0004056	argininosuccinate lyase activity	Extinctions
GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
GO:0005104	fibroblast growth factor receptor binding	Extinctions
GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor	Extinctions
GO:0042586	peptide deformylase activity	Extinctions
GO:0033862	UMP kinase activity	Extinctions
GO:0050694	galactose 3-O-sulfotransferase activity	Extinctions
GO:0036400	short neuropeptide F receptor activity	Extinctions
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
GO:0008829	dCTP deaminase activity	Extinctions
GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	Extinctions
GO:0042954	lipoprotein transporter activity	Extinctions
GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
GO:0004769	steroid delta-isomerase activity	Extinctions
GO:0004720	protein-lysine 6-oxidase activity	Extinctions
GO:0001733	galactosylceramide sulfotransferase activity	Extinctions
GO:0001735	prenylcysteine oxidase activity	Extinctions
GO:0036082	extracellular phenylacetaldehyde-gated ion channel activity	Extinctions
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:0015081	sodium ion transmembrane transporter activity	Extinctions
GO:0005272	sodium channel activity	Extinctions
GO:0004519	endonuclease activity	Extinctions