GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0015929	hexosaminidase activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0097003	adipokinetic hormone receptor activity	Gains
GO:0097004	adipokinetic hormone binding	Gains
GO:0052869	arachidonic acid omega-hydroxylase activity	Gains
GO:0052870	tocopherol omega-hydroxylase activity	Gains
GO:0052871	alpha-tocopherol omega-hydroxylase activity	Gains
GO:0050051	leukotriene-B4 20-monooxygenase activity	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0017046	peptide hormone binding	Gains
GO:0018685	alkane 1-monooxygenase activity	Gains
GO:0005416	cation:amino acid symporter activity	Gains
GO:0005283	sodium:amino acid symporter activity	Gains
GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0015081	sodium ion transmembrane transporter activity	Gains
GO:0015291	secondary active transmembrane transporter activity	Gains
GO:0005214	structural constituent of chitin-based cuticle	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0015293	symporter activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0019992	diacylglycerol binding	Gains
GO:0052723	inositol hexakisphosphate 1-kinase activity	Gains
GO:0052724	inositol hexakisphosphate 3-kinase activity	Gains
GO:0005432	calcium:sodium antiporter activity	Gains
GO:0000828	inositol hexakisphosphate kinase activity	Gains
GO:0004645	phosphorylase activity	Gains
GO:0000832	inositol hexakisphosphate 5-kinase activity	Gains
GO:0019842	vitamin binding	Gains
GO:0004016	adenylate cyclase activity	Gains
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
GO:0072341	modified amino acid binding	Gains
GO:0015368	calcium:cation antiporter activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0043169	cation binding	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0015294	solute:cation symporter activity	Gains
GO:0046872	metal ion binding	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0005343	organic acid:sodium symporter activity	Gains
GO:0008519	ammonium transmembrane transporter activity	Gains
GO:0015179	L-amino acid transmembrane transporter activity	Gains
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Gains
GO:0004364	glutathione transferase activity	Gains
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
GO:0016500	protein-hormone receptor activity	Gains
GO:0008324	cation transmembrane transporter activity	Gains
GO:0008188	neuropeptide receptor activity	Gains
GO:0033218	amide binding	Gains
GO:0018834	dichloromethane dehalogenase activity	Gains
GO:0008940	nitrate reductase activity	Gains
GO:0036082	extracellular phenylacetaldehyde-gated ion channel activity	Gains
GO:0005026	transforming growth factor beta receptor activity, type II	Gains
GO:0004097	catechol oxidase activity	Gains
GO:0016154	pyrimidine-nucleoside phosphorylase activity	Gains
GO:0043992	histone acetyltransferase activity (H3-K9 specific)	Gains
GO:0030350	iron-responsive element binding	Gains
GO:0034185	apolipoprotein binding	Gains
GO:0008490	arsenite secondary active transmembrane transporter activity	Gains
GO:0008456	alpha-N-acetylgalactosaminidase activity	Gains
GO:0035237	corazonin receptor activity	Gains
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Gains
GO:0044620	ACP phosphopantetheine attachment site binding	Gains
GO:0000036	acyl carrier activity	Gains
GO:0016785	transferase activity, transferring selenium-containing groups	Gains
GO:0005329	dopamine transmembrane transporter activity	Gains
GO:0031177	phosphopantetheine binding	Gains
GO:0004375	glycine dehydrogenase (decarboxylating) activity	Gains
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
GO:0004321	fatty-acyl-CoA synthase activity	Gains
GO:0003785	actin monomer binding	Gains
GO:0070273	phosphatidylinositol-4-phosphate binding	Gains
GO:0004459	L-lactate dehydrogenase activity	Gains
GO:0015054	gastrin receptor activity	Gains
GO:0043334	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Gains
GO:0003838	sterol 24-C-methyltransferase activity	Gains
GO:0009703	nitrate reductase (NADH) activity	Gains
GO:0036263	L-DOPA monooxygenase activity	Gains
GO:0036264	dopamine monooxygenase activity	Gains
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	Gains
GO:0008829	dCTP deaminase activity	Gains
GO:0052692	raffinose alpha-galactosidase activity	Gains
GO:0008679	2-hydroxy-3-oxopropionate reductase activity	Gains
GO:0097109	neuroligin family protein binding	Gains
GO:0030623	U5 snRNA binding	Gains
GO:0015446	ATPase-coupled arsenite transmembrane transporter activity	Gains
GO:0004807	triose-phosphate isomerase activity	Gains
GO:0016918	retinal binding	Gains
GO:0004557	alpha-galactosidase activity	Gains
GO:0004587	ornithine-oxo-acid transaminase activity	Gains
GO:0015175	neutral amino acid transmembrane transporter activity	Gains
GO:0015105	arsenite transmembrane transporter activity	Gains
GO:0033192	calmodulin-dependent protein phosphatase activity	Gains
GO:0051192	prosthetic group binding	Gains
GO:0009032	thymidine phosphorylase activity	Gains
GO:0015222	serotonin transmembrane transporter activity	Gains
GO:0019811	cocaine binding	Gains
GO:0042943	D-amino acid transmembrane transporter activity	Gains
GO:0051766	inositol trisphosphate kinase activity	Gains
GO:0070330	aromatase activity	Gains
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Gains
GO:0071617	lysophospholipid acyltransferase activity	Gains
GO:0016787	hydrolase activity	Losses
GO:0004527	exonuclease activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0003678	DNA helicase activity	Losses
GO:0008859	exoribonuclease II activity	Losses
GO:0008527	taste receptor activity	Losses
GO:0009008	DNA-methyltransferase activity	Losses
GO:0033041	sweet taste receptor activity	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0000156	phosphorelay response regulator activity	Losses
GO:0003824	catalytic activity	Losses
GO:0004518	nuclease activity	Losses
GO:0030170	pyridoxal phosphate binding	Losses
GO:0070279	vitamin B6 binding	Losses
GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
GO:0005385	zinc ion transmembrane transporter activity	Losses
GO:0008195	phosphatidate phosphatase activity	Losses
GO:0004751	ribose-5-phosphate isomerase activity	Losses
GO:0003913	DNA photolyase activity	Losses
GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	Losses
GO:0003777	microtubule motor activity	Losses
GO:0003774	motor activity	Losses
GO:0030246	carbohydrate binding	Losses
GO:0042578	phosphoric ester hydrolase activity	Losses
GO:0008233	peptidase activity	Losses
GO:0016791	phosphatase activity	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0046915	transition metal ion transmembrane transporter activity	Losses
GO:0004035	alkaline phosphatase activity	Losses
GO:0005344	oxygen carrier activity	Losses
GO:1901677	phosphate transmembrane transporter activity	Losses
GO:0005452	inorganic anion exchanger activity	Losses
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Losses
GO:0015114	phosphate ion transmembrane transporter activity	Losses
GO:0008509	anion transmembrane transporter activity	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0005506	iron ion binding	Losses
GO:0000156	phosphorelay response regulator activity	Extinctions
GO:0033041	sweet taste receptor activity	Extinctions
GO:0004751	ribose-5-phosphate isomerase activity	Extinctions
GO:0005506	iron ion binding	Extinctions
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0008527	taste receptor activity	Extinctions
GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0004725	protein tyrosine phosphatase activity	Extinctions
GO:0030983	mismatched DNA binding	Extinctions
GO:0008172	S-methyltransferase activity	Extinctions
GO:0016803	ether hydrolase activity	Extinctions
GO:0016307	phosphatidylinositol phosphate kinase activity	Extinctions
GO:0046915	transition metal ion transmembrane transporter activity	Extinctions