Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00004 PF01434 0 1 0 0 0 0 PF00005 PF00664 1 0 0 0 0 0 PF00005 PF00664 PF00005 1 0 0 0 0 0 PF00005 PF12698 PF00005 1 0 0 0 0 0 PF00008 PF12661 PF00008 1 0 0 0 0 0 PF00009 0 1 0 0 0 0 PF00017 PF00617 1 0 0 0 0 0 PF00018 PF00017 1 0 0 0 0 0 PF00050 PF07648 1 0 0 0 0 0 PF00052 PF00053 0 1 0 0 0 0 PF00055 PF00053 0 1 0 0 0 0 PF00076 PF03399 1 0 0 0 0 0 PF00078 PF10545 1 0 0 0 0 0 PF00090 PF05986 1 0 0 0 0 0 PF00090 PF07679 1 0 0 0 0 0 PF00092 0 0 1 0 0 0 PF00094 0 1 0 0 0 0 PF00111 0 1 0 0 0 0 PF00117 0 0 3 0 0 0 PF00125 PF00621 1 0 0 0 0 0 PF00133 PF09334 1 0 0 0 0 0 PF00168 PF00169 1 0 0 0 0 0 PF00169 PF00620 1 0 0 0 0 0 PF00181 PF03947 PF00203 1 0 0 0 0 0 PF00198 0 0 3 0 0 0 PF00200 0 0 2 0 0 0 PF00240 PF00627 0 1 0 0 0 0 PF00270 PF00271 PF16124 PF09382 0 0 1 0 0 0 PF00293 PF01026 1 0 0 0 0 0 PF00310 0 0 5 0 0 0 PF00318 PF00889 1 0 0 0 0 0 PF00333 0 1 0 0 0 0 PF00388 PF00017 1 0 0 0 0 0 PF00400 PF01784 1 0 0 0 0 0 PF00448 0 0 3 0 0 0 PF00467 0 0 2 0 0 0 PF00549 0 1 1 0 0 0 PF00578 PF10417 PF07992 1 0 0 0 0 0 PF00622 PF13671 1 0 0 0 0 0 PF00636 0 0 3 0 0 0 PF00643 PF01436 1 0 0 0 0 0 PF00651 0 1 0 0 0 0 PF00690 PF00122 1 0 4 0 0 0 PF00725 0 0 3 0 0 0 PF00732 PF05199 PF00732 1 0 0 0 0 0 PF00751 0 1 0 0 0 0 PF00752 0 1 1 0 0 0 PF00782 0 1 0 0 0 0 PF00867 0 1 0 0 0 0 PF00868 PF01841 0 1 0 0 0 0 PF00883 0 1 0 0 0 0 PF00919 0 1 0 0 0 0 PF00927 0 1 0 0 0 0 PF00989 0 1 0 0 0 0 PF01017 0 0 1 0 0 0 PF01025 PF00579 1 0 0 0 0 0 PF01087 0 0 1 0 0 0 PF01106 0 0 1 0 0 0 PF01315 PF02738 0 0 5 0 0 0 PF01321 PF16189 PF00557 0 1 0 0 0 0 PF01347 PF09172 0 1 0 0 0 0 PF01398 0 1 0 0 0 0 PF01553 0 1 0 0 0 0 PF01571 0 1 0 0 0 0 PF01799 PF00941 PF03450 PF01315 PF02738 0 1 0 0 0 0 PF01883 PF10609 1 0 0 0 0 0 PF02017 0 1 0 0 0 0 PF02145 PF00780 1 0 0 0 0 0 PF02204 PF12796 PF00023 PF12796 1 0 0 0 0 0 PF02207 0 1 0 0 0 0 PF02770 0 1 2 0 0 0 PF02771 0 1 0 0 0 0 PF02789 0 1 0 0 0 0 PF02812 0 0 1 0 0 0 PF02824 0 0 2 0 0 0 PF02854 0 1 0 0 0 0 PF02882 PF01268 0 0 1 0 0 0 PF03051 0 0 0 0 1 0 PF03097 0 1 0 0 0 0 PF03104 PF00136 0 1 1 0 0 0 PF03129 0 1 0 0 0 0 PF03144 PF14492 PF03764 PF00679 0 1 2 0 0 0 PF03224 0 0 1 0 0 0 PF03474 0 1 0 0 0 0 PF03712 0 0 3 0 0 0 PF03719 0 1 0 0 0 0 PF03807 0 1 0 0 0 0 PF03987 PF10381 0 0 1 0 0 0 PF04050 0 1 0 0 0 0 PF04055 PF01938 0 1 0 0 0 0 PF04266 0 1 0 0 0 0 PF04774 0 0 1 0 0 0 PF04840 0 1 0 0 0 0 PF04841 0 1 0 0 0 0 PF05221 0 0 1 0 0 0 PF05742 0 0 0 0 1 0 PF06221 0 1 0 0 0 0 PF06480 0 1 0 0 0 0 PF07517 0 0 2 0 0 0 PF07571 0 0 1 0 0 0 PF07707 PF08005 0 1 0 0 0 0 PF07724 0 1 0 0 0 0 PF08442 0 1 0 0 0 0 PF08490 0 1 0 0 0 0 PF08669 0 1 0 0 0 0 PF08709 PF02815 1 0 0 0 0 0 PF08953 PF00400 0 1 0 0 0 0 PF08969 0 1 0 0 0 0 PF09230 0 1 0 0 0 0 PF09280 PF00627 0 1 0 0 0 0 PF10170 0 0 0 0 1 0 PF10176 0 0 0 0 1 0 PF10373 0 1 0 0 0 0 PF10374 0 1 0 0 0 0 PF10431 0 1 8 0 0 0 PF11232 0 1 0 0 0 0 PF11265 0 1 0 0 0 0 PF11793 0 0 1 0 0 0 PF11979 0 0 2 0 0 0 PF12775 PF12780 0 1 0 0 0 0 PF12777 PF12781 PF03028 0 1 0 0 0 0 PF12796 PF00023 PF12796 PF00023 1 0 0 0 0 0 PF12796 PF00023 PF13637 PF12796 1 0 0 0 0 0 PF12796 PF01734 1 0 0 0 0 0 PF12796 PF13637 PF00023 1 0 0 0 0 0 PF13181 PF00515 1 0 0 0 0 0 PF13181 PF13424 1 0 0 0 0 0 PF13306 PF13855 1 0 0 0 0 0 PF13393 0 1 0 0 0 0 PF13414 PF13181 1 0 0 0 0 0 PF13415 0 1 0 0 0 0 PF13418 0 1 0 0 0 0 PF13445 PF00643 1 0 0 0 0 0 PF13499 PF00036 1 0 0 0 0 0 PF13764 0 1 0 0 0 0 PF13843 PF05225 1 0 0 0 0 0 PF13857 PF12796 1 0 0 0 0 0 PF13857 PF12796 PF13637 PF12796 1 0 0 0 0 0 PF13894 PF00096 PF00046 1 0 0 0 0 0 PF13894 PF00096 PF13912 1 0 0 0 0 0 PF13912 PF13894 PF00096 1 0 0 0 0 0 PF13927 PF00047 PF13927 1 0 0 0 0 0 PF13949 0 1 0 0 0 0 PF14598 0 1 0 0 0 0 PF14671 0 1 0 0 0 0 PF14727 0 1 0 0 0 0 PF14728 0 1 0 0 0 0 PF14748 0 1 0 0 0 0 PF14837 0 1 0 0 0 0 PF14838 0 1 0 0 0 0 PF16076 0 1 0 0 0 0 PF16188 0 1 0 0 0 0 PF16300 0 1 0 0 0 0 PF16486 PF08699 PF02170 0 0 2 0 0 0 PF16565 0 0 1 0 0 0